ライフサイエンスコーパス: trifluoroethanol

1 and a 1:1 (v/v) mixture of CH2Cl2 and 2,2,2-trifluoroethanol.

2 creased by 1.7 kcal/mol in a protic solvent, trifluoroethanol.

3 ximal I(SC) are predominantly helical in 40% trifluoroethanol.

4 elices under conditions of high salt, or 65% trifluoroethanol.

5 alpha helix in the helix-stabilizing solvent trifluoroethanol.

6 ic spectra obtained in the presence of 2,2,2-trifluoroethanol.

7 repared at neutral pH in the presence of 20% trifluoroethanol.

8 dency to adopt alpha-helical conformation in trifluoroethanol.

9 le reactivity toward the neutral nucleophile trifluoroethanol.

10 n in the presence of the hydrophobic solvent trifluoroethanol.

11 les, with 12% helicity induced in 50% v/v of trifluoroethanol.

12 rresponding imidazolium salts in basic 2,2,2-trifluoroethanol.

13 tion and aggregation propensity triggered by trifluoroethanol.

14 , melittin, in the presence of a denaturant, trifluoroethanol.

15 cis prolines, whereas none are detectable in trifluoroethanol.

16 idic pH and a cationic surfactant but not by trifluoroethanol.

17 ed S2-HR2) in the presence of the co-solvent trifluoroethanol.

18 rimethylamine N-oxide or the cosolvent 2,2,2-trifluoroethanol.

19 acetonitrile, dimethyl sulfoxide, and 2,2,2-trifluoroethanol.

20 pha-helix in solution in the presence of 30% trifluoroethanol.

21 luding a zinc-coordinated substrate analogue trifluoroethanol.

22 nate (BAHA, 1.1 equiv) in aqueous 0.05 N HCl/trifluoroethanol (1-10:1) at room temperature (25 degree

23 s equilibrium between methanol (2(MeOD)) and trifluoroethanol (2(TFE)) adducts, with methanol binding

24 st, upon the addition of moderate amounts of trifluoroethanol (30%), the peptides adopted an alpha-he

25 8), 2-propanol (28 ps, KIE = 1.4), and 2,2,2-trifluoroethanol (4.4 ps, KIE = 3.2), which indicates th

26 In the presence of trifluoroethanol (50% [w/v]), the protein acquired a 30%

27 udied the unfolded ensemble populated in 50% trifluoroethanol, a denaturant that induces a highly hel

28 in aqueous solutions containing 40-80% 2,2,2-trifluoroethanol, a lipomimetic solvent, and was maximal

29 cally nonhelical and highly flexible even in trifluoroethanol, a solvent known to promote and stabili

30 lding, was dramatically accelerated by 2,2,2-trifluoroethanol, a solvent that stabilizes alpha-helica

31 the less nucleophilic solvent mixture of 1:9 trifluoroethanol:acetonitrile, with no formation of seco

32 High concentrations (>50%, v/v) of 2,2,2-trifluoroethanol also dissociate TTR(10-19) fibrils to t

33 ide, a folding inducing organic osmolyte, or trifluoroethanol, an alpha-helix inducer, alpha-helical

34 res for secondary structure, was modified in trifluoroethanol, an organic solvent that represents a m

35 complex with NAD and the substrate analogue trifluoroethanol and a 2.6 A complex with the isosteric

36 ponding silyl enol ethers were prepared from trifluoroethanol and chlorotrialkylsilanes in the presen

37 The fluorous alcohols trifluoroethanol and hexafluoro-2-propanol efficiently p

38 Trifluoroethanol and hexafluoroisopropanol were particul

39 ular Type-II 4 + 3 cycloaddition reaction in trifluoroethanol and hexafluoropropan-2-ol solvents, gen

40 tus PufX exhibited 59 and 55% alpha-helix in trifluoroethanol and in 0.80% octylglucoside in water, r

41 lyzed by circular dichroism in aqueous 2,2,2-trifluoroethanol and in buffered aqueous solutions, both

42 structures analysed, using 1H NMR and CD, in trifluoroethanol and in dodecylphosphocholine micelles.

43 s-they are insoluble in aqueous solutions or trifluoroethanol and instead are soluble in organic solv

44 tides were predominantly (40-80%) helical in trifluoroethanol and most trifluoroethanol-water mixture

45 c channel proteins were transferred to 2,2,2-trifluoroethanol and reconstituted into vesicle membrane

46 of nociceptin in membrane-like environments (trifluoroethanol and SDS micelles) and found it to have

47 The behaviour of the same peptides in trifluoroethanol and SDS solutions is consistent with fo

48 ar levels of alpha-helicity were observed in trifluoroethanol and the peptide appeared to adopt alpha

49 lices in the lower dielectric solvents 2,2,2-trifluoroethanol, and a 1:1 (v/v) mixture of CH2Cl2 and

50 The method was validated with 2,2,2-trifluoroethanol, and applied to analyze heptafluorobuta

51 ronsted acid proton source (water, methanol, trifluoroethanol, and phenol) that is required for this

52 d in acetonitrile solutions containing 2,2,2-trifluoroethanol, and several Arrhenius functions were d

53 in in solution in the presence of liposomes, trifluoroethanol, and sodium dodecyl sulfate indicated t

54 n aqueous solutions but partially helical in trifluoroethanol/aqueous and hexafluoroisopropanol/aqueo

55 solution structure of the C5 peptide in 40% trifluoroethanol/aqueous buffer was determined by NMR sp

56 In particular, additions of 2,2,2-trifluoroethanol as a hydrogen bond donor in solution as

57 onia as the amine component, employing 2,2,2-trifluoroethanol as a non-nucleophilic solvent in order

58 Use of trifluoroethanol as a solvent allowed for significant im

59 o the success of this approach is the use of trifluoroethanol as a solvent and high-power light-emitt

60 oltammetry studies show that both phenol and trifluoroethanol as proton sources exhibit the largest p

61 igh-resolution NMR structure of GlyR TM23 in trifluoroethanol as the starting template.

62 I(CO)(3)(n(3)-C(3)H(5)), in combination with trifluoroethanol, as illustrated by the first enantiosel

63 n alpha-helix content of 100% in 100% 2, 2,2-trifluoroethanol at 0 degrees C.

64 cetone, acetonitrile, ethanol, methanol, and trifluoroethanol at 0 degrees C.

65 cyclo[D-Asp(i),Dap(i+3)] derivatives in 80% trifluoroethanol at 25 and 5 degrees C suggested differe

66 rocess, the oxygenated substrates reacted in trifluoroethanol at lambda = 350 nm by a two-photon casc

67 peptides from TFE/H2O mixtures (TFE = 2,2, 2-trifluoroethanol) back to water, the thermal unfolding c

68 s, lipopolysaccharide (LPS) dispersions, and trifluoroethanol buffer systems.

69 ded towards an alpha-helical conformation in trifluoroethanol buffer, indicating that these regions a

70 es 12-18 for one peptide, CPY-Pl1, formed in trifluoroethanol buffer.

71 helical structure in the presence of SDS or trifluoroethanol but are predominantly unstructured in a

72 osylated wild type enzyme is reactive toward trifluoroethanol but not anions.

73 In contrast, trifluoroethanol caused dissociation of [MAL-6-alpha2]2

74 Trifluoroethanol challenge coupled with circular dichroi

75 The NAD-trifluoroethanol complex crystallizes in the closed conf

76 and properties of the 1:2 boron trifluoride-trifluoroethanol complex have been further studied using

77 of temperature, denaturant concentration and trifluoroethanol concentration.

78 protein structure, is observed at a critical trifluoroethanol concentration.

79 CD and NMR spectroscopies of the peptide in trifluoroethanol confirmed that hFSHR-(221-252) has the

80 1 is approximately 80% in 1-butanol or 2,2,2-trifluoroethanol, consistent with a previous membrane-fo

81 Inducing folding with trifluoroethanol cosolvent allows us to determine the fo

82 In the presence of trifluoroethanol, CsTx-1 and the long C-terminal part al

83 MeCN-d(3), MeOD-d(4), tetrahydrofuran-d(8), trifluoroethanol-d(3)).

84 A amphipathic helical peptide in a 50% (v/v) trifluoroethanol-d3/water mixture, a membrane-mimic envi

85 In the presence of 2-propanol and trifluoroethanol, dearomatized adducts derived from pyri

86 y omission of the four data points for 2,2,2-trifluoroethanol-ethanol mixtures (F-test value from 155

87 ite its unstructured nature, the addition of trifluoroethanol exhibited an intrinsic potential in thi

88 The trifluoroethanol experiments suggest that the alpha-heli

89 A hydrophobic environment (trifluoroethanol) failed to induce alpha-helix formation

90 nt with a mixture of sodium isopropoxide and trifluoroethanol, followed by the addition of acetic aci

91 of the UV and circular dichroism spectrum in trifluoroethanol for compound 2 suggest that the putativ

92 Two modifiers (2,2,2-trifluoroethanol, formaldehyde) that produce anions with

93 SMAP-29 was flexible in 40% trifluoroethanol, forming two sets of conformers that di

94 2,2-dichloro- > 2-chloro approximately 2,2,2-trifluoroethanol > ethanol.

95 Reactions with pyrazole and trifluoroethanol had biphasic proton release, whereas re

96 c environments such as SDS micelles or water/trifluoroethanol, however, the peptide adopts a structur

97 2,2,2-Trifluoroethanol increased response of more hydrophobic

98 cture determined by NMR in 40% perdeuterated trifluoroethanol indicated that residues 8-17 were helic

99 CD spectra showed that trifluoroethanol induced significant alpha-helical struc

100 Trifluoroethanol induces alpha-helix in both human and m

101 ount of alpha-helix and that the addition of trifluoroethanol induces alpha-helix in both murine and

102 hylcyclobutyl methanesulfonate, 7, reacts in trifluoroethanol is one of retention of configuration.

103 epared from readily available B2O3 and 2,2,2-trifluoroethanol, is as an effective reagent for the dir

104 ile in the more polar hexafluoropropanol and trifluoroethanol it is 562 and 571 nm, respectively.

105 ted by laser flash photolysis (LFP) in 2,2,2-trifluoroethanol (lambda = 580 nm, tau = 690 +/- 10 ns).

106 ride (2) in aqueous methanol, ethanol, 2,2,2-trifluoroethanol, n-propyl alcohol, isopropyl alcohol, a

107 -d (26 ps), 2-propanol-OD (40 ps), and 2,2,2-trifluoroethanol-O-d (14 ps) are longer than those recor

108 rs (methanol, 2-methyl-2-propanol, and 2,2,2-trifluoroethanol) on SmI2-initiated 5-exo-trig ketyl-ole

109 nd the dendrimeric SB056 in water and in 30% trifluoroethanol, on the other hand, yielded essentially

110 +) and unreactive substrate analogues, 2,2,2-trifluoroethanol or 2,3,4,5,6-pentafluorobenzyl alcohol,

111 The addition of trifluoroethanol or high ionic strength induced signific

112 n alpha-helical structure in the presence of trifluoroethanol or lipopolysaccharide.

113 me degree of beta-strand structures in water/trifluoroethanol or phosphate-buffered solutions.

114 ha-helical configurations in the presence of trifluoroethanol or phosphatidylcholine/phosphatidylseri

115 when the peptide is dissolved in n-octanol, trifluoroethanol or sodium dodecyl sulfate micelles, agg

116 ter than in highly ionizing solvents such as trifluoroethanol or trifluoroacetic acid.

117 r in the presence of trimethylamine N-oxide, trifluoroethanol, or a cationic surfactant.

118 ed by addition of dimethyl sulfoxide (DMSO), trifluoroethanol, or ethanol.

119 cated the degree of helicity in H2O, aqueous trifluoroethanol, or micelles.

120 ronsted acids of increasing strength, water, trifluoroethanol, phenol, and acetic acid, have been sys

121 The acidity of trifluoroethanol (pKa 12.4) resembles that of tRNA (12.9

122 he concentrations of the fluorinated alcohol trifluoroethanol promotes dissociation of both alpha 4H

123 A catalytic cycle involving trifluoroethanol radical reaction with isoquinolines has

124 photocatalytic condition) to the C-centered trifluoroethanol radical.

125 (4)](-) (Ar = aryl; R = H, CH(3); L = water, trifluoroethanol) react smoothly with benzene at approxi

126 2-diol, 80% isopropanol, 80% ethanol and 40% trifluoroethanol showed that the organic solvent molecul

127 helical under all conditions if derived from trifluoroethanol solutions, and aggregated in a beta-she

128 benzene at approximately room temperature in trifluoroethanol solvent to yield methane and the corres

129 l precursor, enabling efficient synthesis of trifluoroethanol-substituted heteroarenes.

130 l induction of an alpha-helical structure by trifluoroethanol suffices to accelerate productive foldi

131 In the presence of 25% (v/v) trifluoroethanol (TFE) AcP undergoes partial unfolding a

132 te, and this is facilitated by solvent 2,2,2-trifluoroethanol (TFE) acting as a proton shuttle.

133 The first method uses 2,2,2-trifluoroethanol (TFE) and a large excess of amine.

134 susceptible cells, as well as the ability of trifluoroethanol (TFE) and detergent systems to induce s

135 c strength solutions, and in the presence of trifluoroethanol (TFE) and dodecylphosphocholine (DPC) m

136 sitions induced by organic solvents, such as trifluoroethanol (TFE) and methanol (MeOH), indicating a

137 that promote aggregation in 25% (v/v) 2,2,2 trifluoroethanol (TFE) are different from those that pro

138 3,3,3-hexafluoroisopropanol (HFIP) and 2,2,2-trifluoroethanol (TFE) as reaction media is described.

139 ere we show that low concentrations of 2,2,2-trifluoroethanol (TFE) convert predominately unstructure

140 ) and poly(vinyl pyrrolidone) (PVP) in 2,2,2-trifluoroethanol (TFE) for the generation of PVP/TFE poc

141 te of hen lysozyme formed in 60% (v/v) 2,2,2-trifluoroethanol (TFE) has been studied using hydrogen e

142 oteins in aqueous solutions containing 2,2,2-trifluoroethanol (TFE) have shown that the formation of

143 plete lack of secondary structure, while 40% trifluoroethanol (TFE) induces >90% helicity and is unpe

144 2,2,2-Trifluoroethanol (TFE) is known to stabilize peptide hel

145 2,2,2-Trifluoroethanol (TFE) is widely used to induce helix fo

146 ly), have been measured by using CD in water/trifluoroethanol (TFE) mixtures.

147 , and molecular dynamic simulations in water/trifluoroethanol (TFE) mixtures.

148 2,2,2-Trifluoroethanol (TFE) most stabilizes the alpha-helix-l

149 U) a chemotherapy agent, and the anaesthetic trifluoroethanol (TFE) on structurally distinct mechanos

150 We describe a novel trifluoroethanol (TFE) or hexafluoropropan-2-ol (HFP) me

151 ith significant alpha-helical content in 30% trifluoroethanol (TFE) or in dodecylphosphocholine (DPC)

152 plished with Dowex 1 x 2 (CF3CH2O-) in 2,2,2-trifluoroethanol (TFE) or lithium trifluoroethoxide/TFE.

153 C spectra of IA(3) in water and in 23% 2,2,2-trifluoroethanol (TFE) shows that the individual residue

154 rmined by circular dichroism (CD) spectra in trifluoroethanol (TFE) solution are obtained.

155 termine its conformation in both aqueous and trifluoroethanol (TFE) solutions.

156 Trifluoroethanol (TFE) stabilized a native-like beta-tur

157 Trifluoroethanol (TFE) stabilized the secondary structur

158 ge in negative ion mode by trace addition of trifluoroethanol (TFE) to aqueous samples.

159 The binding of ethanol and 1,1,1-trifluoroethanol (TFE) to both the H(mv) and H(ox) forms

160 , we demonstrate the use of a probe molecule trifluoroethanol (TFE) to characterise the kinetics of p

161 investigated in aqueous buffer and in 2,2,2-trifluoroethanol (TFE) using CD and NMR spectroscopy.

162 3,3,3-hexafluoro-2-propanol (HFIP) and 2,2,2-trifluoroethanol (TFE) using different manganese catalys

163 8 beta-strands, induced by dissolving in 50% trifluoroethanol (TFE) were monitored at neutral and low

164 se active samples were incubated with 2,2,2,-trifluoroethanol (TFE), a product analog that serves as

165 In 30 vol-% trifluoroethanol (TFE), a single continuous helix is evi

166 elical conformation in the presence of 2,2,2-trifluoroethanol (TFE), a solvent known to stabilize hyd

167 olution was compared to the structure in 30% trifluoroethanol (TFE), and clear differences were obser

168 Circular dichroism (CD) in H2O, trifluoroethanol (TFE), and SDS micelles confirmed the i

169 In trifluoroethanol (TFE), Au(OAc(F))(CH2CH2OCH2CF3)(tpy) (

170 f the solvent conditions via the addition of trifluoroethanol (TFE), DMSO, DMF and acetone, uniform f

171 rine nucleosides in the fluorinated alcohols trifluoroethanol (TFE), hexafluoropropan-2-ol (HFP), and

172 se can be converted in vitro, by addition of trifluoroethanol (TFE), into amyloid fibrils of the type

173 elix-stabilizing cosolvents, including 2,2,2-trifluoroethanol (TFE), on the thermodynamics and kineti

174 and propanol and moderate concentrations of trifluoroethanol (TFE), or because of the appearance of

175 Upon addition of trifluoroethanol (TFE), significant shifts are observed

176 In the presence of 25% trifluoroethanol (TFE), the helicity of the peptide is 8

177 , including hexafluoroisopropanol (HFIP) and trifluoroethanol (TFE), to activate the electron-deficie

178 r solvolyses of 28 acid chlorides in 97% w/w trifluoroethanol (TFE)-water spanning over 10 (9) in rat

179 of small amounts of the helicogenic solvent trifluoroethanol (TFE).

180 peptide RGITVNGKTYGR, in water and in water/trifluoroethanol (TFE).

181 4-14; and helix 2, residues 20-29) in 2,2,2-trifluoroethanol (TFE).

182 ions, including aqueous solutions containing trifluoroethanol (TFE).

183 r and in the hydrogen bond-promoting solvent trifluoroethanol (TFE).

184 the alpha-helix-rich conformation driven by trifluoroethanol (TFE).

185 (alphaB) is disordered but inducible in 40% trifluoroethanol (TFE).

186 iposomes and are soluble in SDS micelles and trifluoroethanol (TFE).

187 or alpha-helix formation in water and in 50% trifluoroethanol (TFE).

188 structure upon drying and in the presence of trifluoroethanol (TFE).

189 k(d) from tert-butylbenzene (tBuPh) to 2,2,2-trifluoroethanol (TFE).

190 mediate (10-20% v/v) concentrations of 2,2,2-trifluoroethanol (TFE).

191 rimethylamine N-oxide (TMAO) and the solvent trifluoroethanol (TFE).

192 ly alpha-helical secondary structures in 99% trifluoroethanol (TFE)/H(2)O.

193 re recorded in the solvent system (40% 2,2,2-Trifluoroethanol (TFE)/water), which gave the largest st

194 in the presence of the lipid mimetic solvent trifluoroethanol (TFE; 50% v/v).

195 orted for solvolyses in acetone/water, 2,2,2-trifluoroethanol(TFE)/water, and TFE/ethanol mixtures.

196 (i.e., MeOH and EtOH) and fluorinated (i.e., trifluoroethanol, TFE) alcohols on the secondary structu

197 pectively, 227 and 14 times more slowly with trifluoroethanol than the parent benzhydrylium ion (Ph)2

198 udies indicated that, in the presence of 50% trifluoroethanol, the HIV-1 peptide adopts an alpha-heli

199 f methanol, sodium dodecyl sulfate (SDS), or trifluoroethanol, the sulfoxide yield increases 3-5 time

200 site-selective substitutive oxygenation with trifluoroethanol to afford the desired trifluoromethylar

201 structure in aqueous solution and convert in trifluoroethanol to alpha-helix (PEVT, CEEEI, DispRep) a

202 ous solvents ranging from hydrophilic (e.g., trifluoroethanol) to hydrophobic (e.g., n-propanol).

203 ere assessed using a detailed CD analysis in trifluoroethanol, trifluoroethanol-water mixtures, sodiu

204 otein's guanidine hydrochloride-unfolded and trifluoroethanol-unfolded states.

205 roach has been demonstrated to incorporate a trifluoroethanol unit onto the isoquinolines.

206 In 50% trifluoroethanol (v/v), the peptides are 45% helical as

207 a detailed CD analysis in trifluoroethanol, trifluoroethanol-water mixtures, sodium dodecyl sulfate

208 40-80%) helical in trifluoroethanol and most trifluoroethanol-water mixtures.

209 ear magnetic resonance spectra were taken in trifluoroethanol-water mixtures.

210 s, and structural modeling suggested that in trifluoroethanol/water (1:1) helical subdomains existed

211 ing rate ratios in 40% ethanol/water and 97% trifluoroethanol/water (solvents of similar ionizing pow

212 Both the Ad12 and Ad5 peptides dissolved in trifluoroethanol/water mixtures were found to adopt regu

213 In trifluoroethanol/water mixtures, NAC and NAC-(19-35)-pep

214 is essentially disordered in DMSO, water or trifluoroethanol/water.

215 y observed when weaker nucleophiles, such as trifluoroethanol, were employed.

216 reased markedly in the presence of 50% 2,2,2-trifluoroethanol, which causes loss of tertiary structur

217 cyano stretch of 1 to a higher wavenumber in trifluoroethanol, which is consistent with 1 participati

218 phaeroides PufX exhibited 47% alpha-helix in trifluoroethanol while the core segment containing 43 am