ライフサイエンスコーパス: trimethylamine N-oxide

1 egeneration (eg, ceramides, sphingosine, and trimethylamine N-oxide).

2 alpha-MG (methyl-alpha-glucoside), and TMAO (trimethylamine n-oxide).

3 levels of the adverse gut-derived metabolite trimethylamine N-oxide.

4 c Hofmeister series and mixtures of urea and trimethylamine N-oxide.

5 duction of the disease-associated metabolite trimethylamine N-oxide.

6 ic reduction of either dimethyl sulfoxide or trimethylamine N-oxide.

7 fatty acids and degradation products such as trimethylamine N-oxide.

8 ine, but not nitrite, dimethyl sulfoxide, or trimethylamine N-oxide.

9 axis, as exemplified by indoxyl sulfate and trimethylamine-N-oxide.

10 tive decarbonylation with the bulky reactant trimethylamine-N-oxide.

11 ones such as ethanol, dimethyl sulfoxide, or trimethylamine-N-oxide.

12 ergent, above its CMC ( approximately 0.2%), trimethylamine N-oxide, a folding inducing organic osmol

13 Growing evidence indicates that trimethylamine N-oxide, a gut microbial metabolite of di

14 ering, among other things, the production of trimethylamine N-oxide, a proinflammatory compound assoc

15 such as urea, sugars, guanidinium salts, and trimethylamine N-oxide affect the stability, solubility,

16 erestingly, our experiments demonstrate that trimethylamine- N-oxide, an osmolyte upregulated in deep

17 rom dietary choline and L-carnitine, such as trimethylamine N-oxide and betaine, have recently been i

18 ndole-3-acetic acid; the known uremic toxins trimethylamine n-oxide and hippuric acid; and the hormon

19 ns unclear how circulating concentrations of trimethylamine N-oxide and its related dietary and gut m

20 This includes, for example, trimethylamine N-oxide and short-chain fatty acids.

21 For example, trimethylamine N-oxide and, more recently, phenylacetylg

22 cceptors, e.g., nitrite, dimethyl sulfoxide, trimethylamine-N-oxide and fumerate, and azide, an inhib

23 We used four solutes, glycerol, sucrose, trimethylamine-N-oxide and poly(ethylene glycol) 8000, w

24 e that of urea, which is about twice that of trimethylamine-N-oxide and sucrose.

25 ic oxide, nitrous oxide, 1-azido adamantane, trimethylamine n-oxide, and 1,4-benzoquinone quantitativ

26 oad array of metabolites, including choline, trimethylamine N-oxide, and betaine.

27 erature (30 degrees C), osmolytes (glycerol, trimethylamine N-oxide, and dimethyl sulfoxide), and the

28 levels of liver glycogen, choline, taurine, trimethylamine N-oxide, and glucose and by elevated leve

29 ort-chain fatty acids, secondary bile acids, trimethylamine N-oxide, and phenylacetylglutamine.

30 ne, glycine, choline, cysteine, glutathione, trimethylamine N-oxide, and the ratios glycine:serine, 3

31 e consisting of aconitic acid, hypoxanthine, trimethylamine N-oxide, and threonine differentiated pat

32 nicotinamide N-oxide, methionine sulfoxide, trimethylamine-N-oxide, and dimethyl sulfoxide, although

33 lly relevant metabolites, including choline, trimethylamine-N-oxide, and polyunsaturated fatty acids.

34 f enzyme-monitored turnover experiments with trimethylamine N-oxide as substrate reveal that no subst

35 utamine (beta=-0.06; adjusted-p <0.001), and trimethylamine-N-oxide (beta=-0.05; adjusted-p=0.002) sh

36 ngerprints identified by NMR included BCAAs, trimethylamine N-oxide, beta-hydroxybutyrate, trimethyl

37 All tested osmolytes (trimethylamine N-oxide, betaine, glycerol, proline, treh

38 lamine (TMA) and its subsequent oxidation to trimethylamine N-oxide by hepatic flavin-containing mono

39 at protecting osmolytes such as sorbitol and trimethylamine N-oxide can counteract the denaturing eff

40 ature and high concentrations of glycerol or trimethylamine N-oxide can partially counteract the proc

41 s of gut microbe-derived metabolites such as trimethylamine N-oxide, choline, and crotonobetaine were

42 eased the lag time, whereas the stabilizers, trimethylamine N-oxide dihydrate (TMAO) and sucrose, inc

43 rge-reducing molecules, such as spermine and trimethylamine-N-oxide, enable the opportunity to charac

44 E'0 [NO2-, U(VI), dimethyl sulfoxide, TMAO (trimethylamine N-oxide), fumarate, gamma-FeOOH, SO3(2-),

45 unrelated protective osmolytes, sorbitol and trimethylamine-n-oxide, function by marginally decelerat

46 ted here, the gut microbe-derived metabolite trimethylamine N-oxide has been causally linked to the d

47 ional risk factors, higher concentrations of trimethylamine N-oxide (hazard ratio, 1.15 [95% CI, 1.09

48 phenyl derivative [(tpa(Ph))Fe(II)](-) with trimethylamine N-oxide in acetonitrile solution produces

49 in indole and cresol derivatives, as well as trimethylamine N-oxide, in patients who received ABX tre

50 Addition of trimethylamine N-oxide increases T(m) by approximately 5

51 The folding agent trimethylamine N-oxide induced only a small increase in

52 ipids, glucose, and insulin levels and serum trimethylamine N-oxide level), plasma vitamin B12 level,

53 or S-oxides and an increased specificity for trimethylamine-N-oxide (Me(3)NO), with a greater change

54 the urine profiles included higher levels of trimethylamine-N-oxide, N,N'-dimethylglycine, m-hydroxyp

55 fatty acids) and pathogenic mediators (e.g., trimethylamine N-oxide) of host disease susceptibility h

56 nideality arising from molecular crowding by trimethylamine N-oxide on the self-association behaviour

57 39.5 degrees C) in the presence of glycerol, trimethylamine N-oxide or deuterated water.

58 formation upon the addition of the osmolyte trimethylamine N-oxide or the cosolvent 2,2,2-trifluoroe

59 ther in the presence of the natural osmolyte trimethylamine-N-oxide or through a direct interaction w

60 many pathways, including the trimethylamine/trimethylamine N-oxide pathway, short-chain fatty acids

61 al interest, such as urea (good solvent) and trimethylamine N-oxide (poor solvent), are known to affe

62 ranched-chain amino acid (BCAA) degradation, trimethylamine-N-oxide production, and beta oxidation of

63 ites, tryptophan, leucine, tyrosine, valine, trimethylamine N-oxide, proline, oleamide, pyruvic acid,

64 Flow cytometric screening of trimethylamine N-oxide reductase (TorA) leader peptide l

65 rophobic (h-) region of the Escherichia coli trimethylamine N-oxide reductase (TorA) signal peptide i

66 t the green fluorescent protein fused to the trimethylamine N-oxide reductase (TorA) signal sequence

67 , such as the model (NiFe) hydrogenase-2 and trimethylamine N-oxide reductase (TorA) systems, acquire

68 and a truncated version of the Tat substrate trimethylamine N-oxide reductase (TorA502) bearing an RR

69 sulfoxide reductase, and Shewanella massilia trimethylamine N-oxide reductase as the templates.

70 of the native Esherichia coli Tat substrate trimethylamine N-oxide reductase with a twin-lysine subs

71 MSOR = dimethyl sulfoxide reductase, TMAOR = trimethylamine N-oxide reductase)

72 DMSOR = dimethylsulfoxide reductase, TMAOR = trimethylamine N-oxide reductase) members of the title e

73 Dimethyl sulfoxide reductase (DMSOR), trimethylamine-N-oxide reductase (TMAOR), and biotin sul

74 Functional pathways related to trimethylamine-N-oxide reductase and Kdo(2)-lipid A bios

75 of S. cerevisiae with the chemical chaperone trimethylamine-N-oxide resulted in near complete restora

76 es T(m) by approximately 5 degrees C per 1 M trimethylamine N-oxide, resulting in stable triple-helix

77 the naturally occurring protecting osmolytes trimethylamine N-oxide, sarcosine, sucrose, and proline

78 cluding the production of trimethylamine and trimethylamine N-oxide, short-chain fatty acids, and sec

79 d to be specific for chicken intake, whereas trimethylamine-N-oxide showed good specificity for fish.

80 lamines (glycerophosphocholine, betaine, and trimethylamine N-oxide), substrates (DL-glyceraldehyde a

81 Other osmolytes such as trimethylamine N-oxide, sucrose, and betaine also reacti

82 conditions (pH 5.7-8.2, 0-40% sucrose, 0-2 M trimethylamine N-oxide) suggest that the salt-induced di

83 complements the action of osmolytes, such as trimethylamine N-oxide, that favor more compact protein

84 acids, select unsaturated lipid species, and trimethylamine-N-oxide), thus in effect linking diverse

85 the fluctuations of the native state, while trimethylamine N-oxide (TMAO) affects function in the op

86 dietary lipid phosphatidylcholine--choline, trimethylamine N-oxide (TMAO) and betaine--were identifi

87 between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) and several cardiometaboli

88 include the cellular osmolytes glycerol and trimethylamine N-oxide (TMAO) and the organic solvent di

89 tion in the presence of the natural osmolyte trimethylamine N-oxide (TMAO) and the solvent trifluoroe

90 tions of the gut bacteria choline metabolite trimethylamine N-oxide (TMAO) are associated with athero

91 s of the gut microbiota-dependent metabolite trimethylamine N-oxide (TMAO) are associated with preval

92 Elevated serum levels of trimethylamine N-oxide (TMAO) are reported to promote th

93 Trimethylamine (TMA) and trimethylamine N-oxide (TMAO) are widespread in the ocea

94 ium isolated from a forest soil, can grow on trimethylamine N-oxide (TMAO) as a sole nitrogen source;

95 grow on either dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO) as the sole terminal elect

96 (arc) and anaerobic respiration (dms), using trimethylamine N-oxide (TMAO) as the terminal electron a

97 esent study, we show that a natural osmolyte trimethylamine N-oxide (TMAO) at the optimal 1 m concent

98 er, TmaT, and oxidize intracellular TMA into trimethylamine N-oxide (TMAO) by a TMA monooxygenase, Mp

99 perature (T(F)) changes linearly as urea and trimethylamine N-oxide (TMAO) concentrations increase.

100 lt and urea increase the Km's of enzymes and trimethylamine N-oxide (TMAO) counteracts these effects

101 The osmolyte trimethylamine N-oxide (TMAO) did not affect the structu

102 sus belief that protective osmolytes such as trimethylamine N-oxide (TMAO) favor protein folding by b

103 Plasma trimethylamine N-oxide (TMAO) has drawn much attention a

104 Among these, trimethylamine N-oxide (TMAO) has emerged as an enigmati

105 The potential role for choline metabolite trimethylamine N-oxide (TMAO) in cardiovascular disease

106 Experimental studies suggest involvement of trimethylamine N-oxide (TMAO) in the aetiology of cardio

107 We have found that the natural osmolyte trimethylamine N-oxide (TMAO) induces secondary structur

108 Gut microbiome-derived trimethylamine N-oxide (TMAO) induces vascular dysfuncti

109 The gut microbiome-derived metabolite trimethylamine N-oxide (TMAO) induces vascular dysfuncti

110 Although rodent studies suggest that trimethylamine N-oxide (TMAO) influences glucose homeost

111 Trimethylamine N-oxide (TMAO) is a biologically active m

112 Trimethylamine N-oxide (TMAO) is a common osmolyte found

113 Trimethylamine N-oxide (TMAO) is a dietary metabolite th

114 Trimethylamine n-oxide (TMAO) is a naturally occurring o

115 Trimethylamine N-oxide (TMAO) is a solute concentrated i

116 Although increasing evidence suggests that trimethylamine N-oxide (TMAO) is associated with atheros

117 The host-microbiota co-metabolite trimethylamine N-oxide (TMAO) is linked to increased car

118 ectron acceptor dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO) is manifested by the molyb

119 Trimethylamine N-oxide (TMAO) is produced in the gut via

120 , we detect associations with fasting plasma trimethylamine N-oxide (TMAO) levels, a gut microbiota-d

121 esis was associated with elevation of plasma trimethylamine N-oxide (TMAO) levels.

122 ctate as the sole carbon source, with either trimethylamine N-oxide (TMAO) or fumarate as an electron

123 the metaorganismal (i.e., diet-microbe-host) trimethylamine N-oxide (TMAO) pathway has been linked to

124 that gut microbe-targeted inhibition of the trimethylamine N-oxide (TMAO) pathway protects mice agai

125 Trimethylamine N-oxide (TMAO) reductases are widespread

126 We show that the osmolytes urea and trimethylamine N-oxide (TMAO) shift the population of ID

127 in aqueous solutions of urea, methanol, and trimethylamine N-oxide (TMAO) show clearly the effects o

128 The common osmolyte trimethylamine N-oxide (TMAO) stabilizes proteins agains

129 urally occurring protein-protective osmolyte trimethylamine N-oxide (TMAO) that stabilizes cellular p

130 along with the charge-reducing properties of trimethylamine N-oxide (TMAO) to characterize a large nu

131 endent formation of trimethylamine (TMA) and trimethylamine N-oxide (TMAO) via a multistep pathway in

132 olymer brush based on the protein stabilizer trimethylamine N-oxide (TMAO) was developed as an outsta

133 The protective osmolyte trimethylamine N-oxide (TMAO) was used to induce folding

134 association of the proatherogenic metabolite trimethylamine N-oxide (TMAO) with cardiovascular outcom

135 Trimethylamine N-oxide (TMAO), a compound derived from d

136 Trimethylamine N-oxide (TMAO), a gut microbe-dependent m

137 Trimethylamine N-oxide (TMAO), a gut microbiota metaboli

138 se (CKD) have elevated circulating levels of trimethylamine N-oxide (TMAO), a metabolite derived from

139 Trimethylamine N-oxide (TMAO), a metabolite from red mea

140 Dietary choline is a precursor of trimethylamine N-oxide (TMAO), a metabolite that has bee

141 atomic force microscopy measurements, unless trimethylamine N-oxide (TMAO), a natural occurring osmol

142 Little is known about associations of trimethylamine N-oxide (TMAO), a novel gut microbiota-ge

143 The molecular orientation of trimethylamine N-oxide (TMAO), a powerful protein stabil

144 g osmolyte, shifts the equilibrium toward U; trimethylamine N-oxide (TMAO), a protecting osmolyte, sh

145 We have used trimethylamine N-oxide (TMAO), a protecting osmolyte, to

146 ssue of Blood, Wu and colleagues report that trimethylamine N-oxide (TMAO), an intestinal microbiome-

147 The use of trimethylamine N-oxide (TMAO), an osmolyte that stabiliz

148 Although it is widely known that trimethylamine N-oxide (TMAO), an osmolyte used by natur

149 Urinary trimethylamine (TMA), trimethylamine N-oxide (TMAO), and 1-methylnicotinamide

150 nvestigating the effects of three osmolytes, trimethylamine N-oxide (TMAO), betaine, and glycine, on

151 toxins, including tryptophan metabolites and trimethylamine N-oxide (TMAO), can lower the risk of CVD

152 Chemical chaperones, such as trimethylamine N-oxide (TMAO), can prevent formation of

153 ats with active or relapsing vasculitis were trimethylamine N-oxide (TMAO), citrate and 2-oxoglutarat

154 Trimethylamine N-oxide (TMAO), derived from gut microbes

155 now show gut microbes, through generation of trimethylamine N-oxide (TMAO), directly contribute to pl

156 A gut-microbial metabolite, trimethylamine N-oxide (TMAO), has been associated with

157 Serum creatinine, trimethylamine N-oxide (TMAO), indoxyl sulfate (IS) and

158 nd microbiome-dependent metabolites, such as trimethylamine N-oxide (TMAO), may explain differential

159 umarate, nitrate, dimethyl sulfoxide (DMSO), trimethylamine N-oxide (TMAO), nitrite, and insoluble ir

160 the presence of dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO), R. sphaeroides 2.4.1T uti

161 t in buffers containing the natural osmolyte trimethylamine N-oxide (TMAO), recombinant AF1 folds int

162 ectron acceptor dimethyl sulfoxide (DMSO) or trimethylamine N-oxide (TMAO), Rhodobacter sphaeroides 2

163 ectron acceptors tested, including fumarate, trimethylamine N-oxide (TMAO), thiosulfate, dimethyl sul

164 traordinary capability of one such osmolyte, trimethylamine N-oxide (TMAO), to force two thermodynami

165 apability of the naturally occurring solute, trimethylamine N-oxide (TMAO), to force two unfolded pro

166 g the gut-derived cardiovascular risk factor trimethylamine N-oxide (TMAO), were used to evaluate the

167 We study the effect of the osmolyte, Trimethylamine N-Oxide (TMAO), which accumulates in cell

168 FMO3 produces trimethylamine N-oxide (TMAO), which has recently been s

169 deleterious effects of metabolites, such as trimethylamine N-oxide (TMAO), which have been studied a

170 Trimethylamine N-oxide (TMAO)-a gut-derived metabolite-i

171 ate anions (ligands) as well as the osmolyte trimethylamine N-oxide (TMAO).

172 m to counteract the effects of urea by using trimethylamine N-oxide (TMAO).

173 tra acquired in the presence of the osmolyte trimethylamine N-oxide (TMAO).

174 ing transition upon addition of the osmolyte trimethylamine N-oxide (TMAO).

175 ine, glycine betaine), and also glycerol and trimethylamine N-oxide (TMAO).

176 ized and is globally altered by the osmolyte trimethylamine N-oxide (TMAO).

177 olism of certain dietary nutrients producing trimethylamine N-oxide (TMAO).

178 levels of the adverse gut-derived metabolite trimethylamine N-oxide (TMAO).

179 nhibited by the naturally occurring osmolyte trimethylamine N-oxide (TMAO).

180 lism [choline, betaine, dimethylglycine, and trimethylamine N-oxide (TMAO)] and colorectal cancer ris

181 ined the relationship between fasting plasma trimethylamine-N-oxide (TMAO) and all-cause mortality ov

182 cing effects between the protecting osmolyte trimethylamine-N-oxide (TMAO) and denaturing osmolyte ur

183 els of the gut-microbiota-derived metabolite trimethylamine-N-oxide (TMAO) and stroke incident risk.

184 Trimethylamine-N-oxide (TMAO) and urea are metabolites t

185 Trimethylamine-N-oxide (TMAO) and urea represent the ext

186 growth to anaerobic respiratory growth with trimethylamine-N-oxide (TMAO) as the terminal electron a

187 Trimethylamine-N-oxide (TMAO) correlates with atheroscle

188 tent with clinical data, and discovered that trimethylamine-N-oxide (TMAO) crosses the blood-brain ba

189 t, to gut microbiota-dependent generation of trimethylamine-N-oxide (TMAO) from L-carnitine, a nutrie

190 Among these metabolites, trimethylamine-N-oxide (TMAO) has been identified as a p

191 Trimethylamine-N-oxide (TMAO) in the cells of sharks and

192 Trimethylamine-N-oxide (TMAO) is a gut microbiome-derive

193 Trimethylamine-N-Oxide (TMAO) is a microbiome-related me

194 Although it is not clear whether trimethylamine-N-oxide (TMAO) is directly transported, t

195 Trimethylamine-N-oxide (TMAO) levels in blood predict fu

196 sted the influence of trehalose, sucrose and trimethylamine-N-oxide (TMAO) on Abeta aggregation and f

197 mulation study of the effect of the osmolyte trimethylamine-N-oxide (TMAO) on hydrophobic phenomena a

198 ne, dimethylamine (DMA), trimethylamine, and trimethylamine-N-oxide (TMAO) with the use of liquid chr

199 Trimethylamine-N-oxide (TMAO), a gut microbial-dependent

200 ucture and compactness is also observed with trimethylamine-N-oxide (TMAO), a naturally occurring osm

201 ations of the naturally occurring osmolytes, trimethylamine-N-oxide (TMAO), sarcosine, betaine, proli

202 ficacy of naturally occurring osmolytes like trimethylamine-N-oxide (TMAO), to offset the deleterious

203 ary source for the gut microbiota metabolite trimethylamine-N-oxide (TMAO), which has been related to

204 ry choline, results in increased exposure to trimethylamine-N-oxide (TMAO), which is purported to be

205 g osmolytes glycerol, proline, sarcosine and trimethylamine-N-oxide (TMAO).

206 The primary outcome was fasting serum trimethylamine-N-oxide (TMAO).

207 oduction of a proatherosclerotic metabolite, trimethylamine-N-oxide (TMAO).

208 her metabolized to a proatherogenic species, trimethylamine-N-oxide (TMAO).

209 subsequent host-driven conversion of TMA to trimethylamine-N-oxide (TMAO).

210 ratures, in acidic pH, or in the presence of trimethylamine N-oxide, trifluoroethanol, or a cationic

211 etabolites, such as short-chain fatty acids, trimethylamine N-oxide, tryptophan derivatives, and bile

212 TMAO (trimethylamine-N-oxide) was used to stabilize the tetram

213 Plasma trimethylamine and trimethylamine-N-oxide were higher in males but lower in

214 novel associations of the plasma metabolite trimethylamine-N-oxide with cardiac arrhythmia and infar