ライフサイエンスコーパス: tristetraprolin

1 ent in cells (e.g., TIA-1) or induced (e.g., tristetraprolin).

2 d the non-ARE-containing RNAs GADD45beta and tristetraprolin.

3 otein HuA and the mRNA-destabilizing protein tristetraprolin.

4 or c-myc mRNA that were poorly recognized by tristetraprolin.

5 e activity of the mRNA-destabilizing protein tristetraprolin.

6 y changed and included the mRNA decay factor Tristetraprolin.

7 egulates meprin alpha expression by inducing tristetraprolin.

8 ta provoked an increase in the expression of tristetraprolin, a homeostatic zinc finger protein that

9 Previous studies have demonstrated that Tristetraprolin, a human protein of the TIS11 family, in

10 Tristetraprolin, a negative regulator of ARE mRNA stabil

11 lly bound to ARE(TNF) mRNA and competed with tristetraprolin, a protein known to bind and destabilize

12 Among the latter was the RNA encoding tristetraprolin, a protein that binds AREs and is known

13 hat are targeted by the RNA-binding protein, tristetraprolin (also known as zinc finger protein 36 (Z

14 Nase binds both to mRNA cap structure and to tristetraprolin, an inducible host protein that sequeste

15 d by the phosphorylation and inactivation of tristetraprolin, an mRNA destabilizing protein that targ

16 In contrast, tristetraprolin, an mRNA destabilizing protein, strongly

17 se in expression and RNA binding activity of tristetraprolin, an mRNA-binding protein that destabiliz

18 Tristetraprolin, an mRNA-binding protein that promotes m

19 f PMR1 with SGs under conditions which cause tristetraprolin and butyrate response factor 1, proteins

20 In contrast, human TZF homologs tristetraprolin and ERF-2 bind with high specificity to

21 interaction of ARE-binding proteins such as tristetraprolin and the four AUF1 isoforms.

22 mined the status of the ARE binding proteins tristetraprolin and TIA-1/TIAR in infected cells.

23 Nup475 (also known as tristetraprolin and TIS11) includes two zinc-binding dom

24 oup of RNA-binding proteins (including TIS11/tristetraprolin and TIS11D) that share characteristic ta

25 The protein Nup475 (also known as Tristetraprolin and TS11) binds to AU-rich sequence elem

26 he activity of the mRNA-destabilizing factor tristetraprolin, and thereby inhibits the expression of

27 Regulation of mRNAs by Tristetraprolin appears to function as one of several cr

28 However, the truncated transcript escaped tristetraprolin binding and downregulation.

29 Earlier, this laboratory reported that tristetraprolin binds VHS RNase.

30 cytotoxic T lymphocyte function mediated by tristetraprolin, contributing to regulation of antitumou

31 In addition, an antibody to tristetraprolin coprecipitated the Vhs protein from lysa

32 Tristetraprolin-deficient [TTP (-/-)] mice exhibit a com

33 IFN-gamma production by naive wild type and tristetraprolin-deficient CD8(+) T-cells is comparable.

34 IL-27 is overproduced by tristetraprolin-deficient macrophages and increased syst

35 rtantly, deletion of IL-27 receptor WSX-1 in tristetraprolin-deficient mice (WSX-1/tristetraprolin do

36 er, tumor growth is accelerated, not only in tristetraprolin-deficient mice after cytotoxic T lymphoc

37 nt macrophages and increased systemically in tristetraprolin-deficient mice.

38 To test the hypothesis that tristetraprolin directs VHS RNase to the AU-rich element

39 Phosphorylation of tristetraprolin does not affect its interaction with CCR

40 ic T lymphocyte depletion, but also in WSX-1/tristetraprolin double knockout mice, with substantial r

41 X-1 in tristetraprolin-deficient mice (WSX-1/tristetraprolin double knockout) leads to a reduction in

42 Here we show that the RNA-binding tristetraprolin, encoded by Zfp36, is needed for CD8(+)

43 d proteins and in vitro assays, we find that tristetraprolin engages CCR4-NOT through multiple intera

44 on of other mRNAs exemplified by GADD45beta, tristetraprolin, etc.

45 Restoring tristetraprolin expression in an aggressive tumor cell l

46 array data sets revealed that suppression of tristetraprolin expression is a negative prognostic indi

47 Collectively, these data establish that tristetraprolin expression is frequently suppressed in h

48 However, the cellular consequences of tristetraprolin expression varied across different cell

49 Moreover, reducing tristetraprolin expression via short hairpin RNA transfe

50 cripts contained potential binding sites for tristetraprolin family member proteins that were conserv

51 bout a recently discovered placenta-specific tristetraprolin family member, ZFP36L3.

52 Partial deficiency of 1 of the 4 mouse tristetraprolin family members, Zfp36l2, resulted in com

53 Members of the tristetraprolin family of CCCH tandem zinc finger protei

54 Members of the mammalian tristetraprolin family of CCCH tandem zinc finger protei

55 Tristetraprolin family of proteins regulate mRNA stabili

56 Members of the tristetraprolin family of tandem CCCH finger proteins ca

57 -containing mRNA stability by competing with tristetraprolin for mRNA binding.

58 Both HuA and tristetraprolin, however, recognized AU-rich sequences f

59 chanisms in macrophages, including p38 MAPK, tristetraprolin, IL-10, and binding of SMAD3 to the IL-2

60 cytoplasmic accumulation, and persistence of tristetraprolin in infected cells.

61 formed to evaluate the expression of HuA and tristetraprolin in purified human T lymphocytes and to e

62 binds the destabilizing ARE-binding protein tristetraprolin induced following activation of HVS-tran

63 Here, we investigate how tristetraprolin interacts with CCR4-NOT and PABPC1 to co

64 ooxygenase-2 transcript, and transfection of tristetraprolin into HCA-7 cells reduced the level of fu

65 Tristetraprolin is a vertebrate CCCH tandem zinc finger

66 modulation of the phosphorylation status of tristetraprolin is an important physiological mechanism

67 Our studies have also shown that tristetraprolin is one of the key players in regulating

68 were examined for the presence of potential tristetraprolin-like binding sites.

69 amino acid in each MEX-5 zinc finger confers tristetraprolin-like specificity to this protein.

70 ripts following T lymphocyte activation, and tristetraprolin may subsequently mediate their degradati

71 crophages, GILZ levels are downregulated via tristetraprolin-mediated GILZ mRNA destabilization.

72 east cancer, because patients with low tumor tristetraprolin mRNA levels were more likely to present

73 ematically dysregulated in cancers; however, tristetraprolin mRNA levels were significantly decreased

74 ell growth and confluence, the expression of tristetraprolin mRNA was inversely correlated with that

75 Still a third, exemplified by tristetraprolin mRNA, is not degraded, allowing its prot

76 These data demonstrate that neither tristetraprolin nor HuR is required for TNF-alpha mRNA e

77 lves the association of ARE-binding proteins tristetraprolin or AUF1 and proteasome activity, of whic

78 Nup475 (also known as tristetraprolin, or TIS11) is the prototype for a family

79 cted cells, the mutant but not the wild-type tristetraprolin precluded the degradation of the AU-rich

80 Satellite cell specific knockdown of Tristetraprolin precociously activates satellite cells i

81 Tristetraprolin promotes the decay of MyoD mRNA, which e

82 We propose that tristetraprolin promotes the processive deadenylation ac

83 lthough absent in resting cells, cytoplasmic tristetraprolin protein was detected 3-6 h following act

84 In contrast, tristetraprolin recognized an AU-rich sequence in interl

85 Here we show that tristetraprolin recruits VHS RNase to the AU-rich elemen

86 several viral and at least one host protein (tristetraprolin) regulate its activity.

87 h elements, we mapped the domains of VHS and tristetraprolin required for their interactions.

88 esulting from decreased activity of TTP, the tristetraprolin RNA-binding protein responsible for mRNA

89 deadenylation activity, but is essential for tristetraprolin's binding to PABPC1.

90 MAPK phosphorylates MAPKAP2 and inactivates Tristetraprolin, stabilizing MyoD mRNA.

91 Tristetraprolin suppresses IL-27 production by promoting

92 The amounts of tristetraprolin that accumulated in the cytoplasm of cel

93 We report that VHS binds to the domain of tristetraprolin that enables its interaction with RNA.

94 shed TNF-alpha ARE-binding proteins, HuR and tristetraprolin, that shuttle between the nucleus and cy

95 th the exception of the destabilizing factor tristetraprolin, the identity and function of the protei

96 to AU-rich elements via its interaction with tristetraprolin, the RNase deadenylates and cleaves the

97 The enhanced binding of tristetraprolin to the MEP1A 3'-UTR results in destabili

98 Tristetraprolin (TTP) acts by binding to AU-rich element

99 complex with the mRNA-destabilizing protein tristetraprolin (TTP) and a conserved adenylate-uridylat

100 nt evidence that in human cells the proteins Tristetraprolin (TTP) and BRF-1 deliver ARE-mRNAs to pro

101 ucleolytic decay, associate with the protein tristetraprolin (TTP) and its homolog BRF-1, which bind

102 Tristetraprolin (TTP) and its two known mammalian family

103 sly, the Reg-2 transcript is destabilized by tristetraprolin (TTP) and Reg-1 through the AREs element

104 Human antigen R (HuR) and Tristetraprolin (TTP) are RNA binding proteins that comp

105 We validate Tristetraprolin (TTP) as a major regulator of RNA degrad

106 We have identified the RNA-binding protein Tristetraprolin (TTP) as a negative regulator of NLRP3 i

107 RNA-binding proteins Hu antigen R (HuR) and tristetraprolin (TTP) bind AU-rich elements in the 3' un

108 Tristetraprolin (TTP) binds AU-rich elements (AREs) enco

109 The mRNA-destabilizing factor tristetraprolin (TTP) binds in a sequence-specific manne

110 The zinc-finger protein tristetraprolin (TTP) binds to AU-rich elements present

111 Tristetraprolin (TTP) binds to the 3'-untranslated regio

112 The zinc finger protein tristetraprolin (TTP) destabilizes several proinflammato

113 Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger

114 lacenta- and yolk sac-specific member of the tristetraprolin (TTP) family of CCCH tandem zinc finger

115 Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger

116 Zfp36l2 is a member of the tristetraprolin (TTP) family of CCCH tandem zinc finger

117 Members of the tristetraprolin (TTP) family of CCCH tandem zinc finger

118 Members of the tristetraprolin (TTP) family of proteins participate in

119 g Ifnb1 mRNA destabilization mediated by the tristetraprolin (TTP) family of RNA-binding proteins and

120 protein 36-like 1 (Zfp36L1), a member of the tristetraprolin (TTP) family of tandem CCCH finger prote

121 sponse factor 1 (TIS11b/BRF1) belongs to the tristetraprolin (TTP) family of zinc-finger proteins, wh

122 c AU-rich motifs are regulated by binding of tristetraprolin (TTP) family tandem zinc finger proteins

123 The zinc-finger protein tristetraprolin (TTP) has been demonstrated to regulate

124 ation and inactivation of mRNA decay factor, Tristetraprolin (TTP) in G0.

125 d uridine-rich element (ARE)-binding protein tristetraprolin (TTP) in influencing mRNA stability of I

126 or T-cell intracellular antigen-1 (TIA-1) or tristetraprolin (TTP) initially do not colocalize with t

127 Tristetraprolin (TTP) is a CCCH tandem zinc finger prote

128 Tristetraprolin (TTP) is a CCCH zinc finger-containing p

129 Tristetraprolin (TTP) is a critical negative immune regu

130 Tristetraprolin (TTP) is a hyperphosphorylated protein t

131 Tristetraprolin (TTP) is a member of the CCCH tandem zin

132 es diverse antiproliferative activities, and tristetraprolin (TTP) is a mitogen-induced RNA-binding p

133 Tristetraprolin (TTP) is a mRNA-destabilizing protein th

134 Tristetraprolin (TTP) is a regulator of TNF-alpha mRNA s

135 Tristetraprolin (TTP) is a tandem CCCH zinc finger prote

136 Tristetraprolin (TTP) is a widely expressed potential tr

137 Tristetraprolin (TTP) is a zinc finger protein that can

138 ere, we report that the destabilizing factor tristetraprolin (TTP) is also ubiquitously expressed in

139 Tristetraprolin (TTP) is an anti-inflammatory protein th

140 Tristetraprolin (TTP) is an anti-inflammatory protein th

141 Tristetraprolin (TTP) is an AU-rich element binding prot

142 Tristetraprolin (TTP) is an inducible zinc finger AU-ric

143 Tristetraprolin (TTP) is an inducible, tandem zinc-finge

144 Tristetraprolin (TTP) is an RNA-binding protein and an e

145 Tristetraprolin (TTP) is an RNA-binding protein required

146 yeloid cells, the mRNA-destabilizing protein tristetraprolin (TTP) is induced and extensively phospho

147 Expression of the immediate early protein tristetraprolin (TTP) is induced by numerous stimuli, in

148 The immediate early gene tristetraprolin (TTP) is induced transiently in many cel

149 lowing TNF treatment, the mRNA decay protein tristetraprolin (TTP) is Lys-63-polyubiquitinated by TNF

150 The immediate early protein tristetraprolin (TTP) is required to prevent inappropria

151 Tristetraprolin (TTP) is the only trans-acting factor sh

152 Tristetraprolin (TTP) is the prototype of a family of CC

153 Zinc finger protein tristetraprolin (TTP) modulates macrophage inflammatory

154 Furthermore, IFN-gamma enhances LPS-induced tristetraprolin (TTP) mRNA expression and protein produc

155 studied the role that Hu antigen R (HuR) and tristetraprolin (TTP) play in regulating the expression

156 The RNA-binding protein tristetraprolin (TTP) plays a central role in PTR by bin

157 of being a negative regulator, we found that tristetraprolin (TTP) positively correlates with HIF-1 t

158 c conditions, the mRNA-destabilizing protein tristetraprolin (TTP) regulates apoptosis and the number

159 Tristetraprolin (TTP) regulates expression at the level

160 Tristetraprolin (TTP) regulates pro-inflammatory process

161 We hypothesized that the ARE-binding protein tristetraprolin (TTP) regulates T lymphocyte IL-2 mRNA d

162 TNF-alpha mRNA stability via the binding of tristetraprolin (TTP) to the adenosine/uridine-rich elem

163 Association of tristetraprolin (TTP) with mRNAs containing selected AU-

164 o impacts on the anti-inflammatory protein - tristetraprolin (TTP), a destabilizing RNA binding prote

165 Tristetraprolin (TTP), a member of the tandem CCCH zinc

166 e degradation of the E47 mRNA and found that tristetraprolin (TTP), a physiological regulator of mRNA

167 Tristetraprolin (TTP), a protein involved in the degrada

168 We report here that mice deficient in tristetraprolin (TTP), a protein with known anti-inflamm

169 We investigated the possibility that tristetraprolin (TTP), a tandem CCCH zinc finger protein

170 In the case of one member of this family, tristetraprolin (TTP), absence of the protein in knockou

171 Here we show that tristetraprolin (TTP), an ARE-binding protein that desta

172 Tristetraprolin (TTP), an mRNA-binding protein, plays a

173 Tristetraprolin (TTP), an RNA-binding protein encoded by

174 We found that overexpression of tristetraprolin (TTP), but not its RNA binding mutant or

175 ein, Zfp36l2, like its better-known relative tristetraprolin (TTP), can decrease the stability of AU-

176 Tristetraprolin (TTP), encoded by the Zfp36 gene, is a z

177 One ARE binding protein, tristetraprolin (TTP), has been implicated in regulating

178 ities and show that the RNA-binding protein, tristetraprolin (TTP), interacts with these elements.

179 ne encoding the putative zinc finger protein tristetraprolin (TTP), is rapidly induced in fibroblasts

180 Here we show that a key destabilizing AUBP, tristetraprolin (TTP), is repressed by the p38 mitogen-a

181 mRNA coding for tumor necrosis factor (TNF), tristetraprolin (TTP), suppressor of cytokine signaling-

182 Tristetraprolin (TTP), the best known member of a class

183 Tristetraprolin (TTP), the prototype of a class of CCCH

184 Tristetraprolin (TTP), the prototype of a class of Cys-C

185 Mice deficient in tristetraprolin (TTP), the prototype of a family of CCCH

186 Tristetraprolin (TTP), the prototype of a small family o

187 Deficiency of tristetraprolin (TTP), the prototype of the CCCH zinc fi

188 nduced expression of the ARE-binding protein tristetraprolin (TTP), which colocalized to P bodies.

189 transcriptionally by the RNA-binding protein tristetraprolin (TTP), which destabilizes IL-10 mRNA in

190 he latter is regulated, at least in part, by tristetraprolin (TTP), which is increased in aged B cell

191 Finally, we demonstrate that the tristetraprolin (TTP)-binding domain, which acts as the

192 Macrophages derived from tristetraprolin (TTP)-deficient mice exhibited increased

193 owever, bone marrow-derived macrophages from tristetraprolin (TTP)-deficient mice were less sensitive

194 In particular, tristetraprolin (TTP)-directed mRNA deadenylation destab

195 pecific and requires the ARE binding protein tristetraprolin (TTP).

196 e/threonine phosphoprotein, XRN1, eIF4E, and tristetraprolin (TTP).

197 ation of the AU-rich element-binding protein tristetraprolin (TTP).

198 lecule farther downstream of p38 MAPK, i.e., tristetraprolin (TTP).

199 eactivity of H(2) S with a ZF protein called tristetraprolin (TTP).

200 at are recognized by the RNA binding protein tristetraprolin (TTP).

201 The protein tristetraprolin (TTP, also known as NUP475 and TIS11) is

202 but is inhibited by the RNA-binding protein tristetraprolin (TTP, encoded by the Zfp36 gene).

203 n the expression of the RNA-binding proteins tristetraprolin (TTP, ZFP36) and HuR (ELAVL1).

204 When coexpressed with the prototypic ARE-BP tristetraprolin (TTP, ZFP36) that mainly destabilizes it

205 nt with its role in moderating inflammation, tristetraprolin (TTP, ZFP36) was among the most highly e

206 Tristetraprolin (TTP, Zfp36, Nup475, Tis11) dramatically

207 The RBP tristetraprolin (TTP/Zfp36) is a signal-induced phosphor

208 ly, Myc directly suppresses transcription of Tristetraprolin (TTP/ZFP36), an mRNA-destabilizing AUBP,

209 in AU-rich cis-elements (AREs) recognized by tristetraprolin (TTP/Zfp36), an RNA-binding protein prev

210 Tristetraprolin (TTP; also known as NUP475, GOS24, or TI

211 We showed that loss of tristetraprolin (TTP; gene ZFP36) increased NF-kappaB ac

212 We find that the fission yeast homologues of Tristetraprolin/TTP and Pumilio/Puf (Zfs1 and Puf3) inte

213 gulation/activity of HuR and inactivation of tristetraprolin, two AU-rich element-binding proteins.

214 Interestingly, the RNA destabilizing protein tristetraprolin was induced following IgE cross-linkage

215 We report that tristetraprolin was made and accumulated in the cytoplas

216 The localization of tristetraprolin was not modified in cells infected with

217 n inhibitory transcription factor, and ZFP36/Tristetraprolin, which binds to AU-rich elements within

218 nactivation of the mRNA-destabilizing factor tristetraprolin, which we show is able to target the IFN

219 estabilizing protein Tis11b, a member of the tristetraprolin/ZFP36 family, and thereby, decreases MR

220 e RNA-binding proteins HuR (ELAVL1) and TTP (tristetraprolin/ZFP36).

221 Tristetraprolin, ZFP36L1, and ZFP36L2 have been shown to

222 rated roles for three of the family members, tristetraprolin, ZFP36L1, and ZFP36L2, in inflammation,

223 tein containing the critical features of the tristetraprolin zinc finger domain.