ライフサイエンスコーパス: trisubstituted

1 for the cis to trans epimerization of 1,2,3-trisubstituted 1,2,3,4-tetrahydro-beta-carbolines, while

2 rapid and stereoselective synthesis of 2,3,4-trisubstituted 1,2,3,4-tetrahydropyridines.

3 thods for the synthesis of enantiopure 1,4,5-trisubstituted 1,2,3-triazoles where the chiral componen

4 A general method for the synthesis of 1,3,5-trisubstituted 1,2,4-triazoles has been developed from r

5 - and site-selective formation of tetra- and trisubstituted 1,3-dienes results from use of Ag(2)O and

6 ic acid (PTSA, 0.1-0.2 equiv) afforded 4,4,5-trisubstituted 1,3-oxazinan-2-ones in good to excellent

7 The challenging C12-C16 bis-trisubstituted 1,4-diene was installed with a complex re

8 t Castagnoli-Cushman-type synthesis of 1,4,6-trisubstituted 1,6-dihydropyridin-2-(3H)-ones from 3-ary

9 ries of nucleoside analogues bearing a 1,4,5-trisubstituted-1,2,3-triazole aglycone was synthesized u

10 d chiroptical properties of nonracemic 1,6,7-trisubstituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole

11 ation of the absolute configuration of 1,6,7-trisubstituted 2,3-dihydro-1H,5H-pyrazolo[1,2-a]pyrazole

12 rd synthetic protocol for constructing 2,3,5-trisubstituted 2-aminothiophenes.

13 The 3,3,3-trisubstituted 2-oxoacids thus produced were converted i

14 approach leading to the discovery of a 3,4,5-trisubstituted-2-aminopyridine series and present the ap

15 If the olefin in the tether was trisubstituted (3'-methyl-2'-butenyloxy), no cycloadditi

16 that details the synthesis of stable acyclic trisubstituted [3]dendralenes and deciphers their struct

17 esis of a series of diversely functionalized trisubstituted 4(5)het(aroyl)-2,5(4)-het(aryl)/alkylimid

18 zole-4-carboxamides were elaborated to novel trisubstituted 4,2'-bisoxazoles through DAST/DBU-mediate

19 fficient straightforward synthesis of 2,5,4'-trisubstituted 4,5'-bisoxazoles via copper(I)-catalyzed

20 4-oxopiperidines then gave the 2,4,6-cis,cis-trisubstituted 4-hydroxypiperidines in high diastereosel

21 s to an efficient one-pot synthesis of 1,3,5-trisubstituted 4-nitropyrrolidin-2-ones (5).

22 elationship (SAR) of a novel series of 2,4,5-trisubstituted-7H-pyrrolo[2,3-d]pyrimidines with potent

23 ing-closing metathesis to form the requisite trisubstituted (8E)-alkene in the 12-membered macrolacto

24 Oxidizable olefins, such as styrenes, trisubstituted aliphatic alkenes, and enamides, can be e

25 This protocol comprises mono-, di-, and trisubstituted aliphatic, alpha-amino, and alpha-oxy aci

26 synthesis is the asymmetric hydroboration of trisubstituted alkene 6.

27 yclic ring-closing metathesis that affords a trisubstituted alkene and is catalyzed by a Mo bis(arylo

28 1,2-bisboronate derivatives can serve as the trisubstituted alkene equivalents to couple with alkynes

29 f other enantiomerically pure, stereodefined trisubstituted alkene intermediates not easily accessibl

30 l-substituted electrophiles bearing a di- or trisubstituted alkene may be employed.

31 In contrast, the trisubstituted alkene moieties contained within the fram

32 ivatized via Stille coupling to a variety of trisubstituted alkene products.

33 ed CAHB of alkyl-substituted methylidene and trisubstituted alkene substrates by pinacolborane (pinBH

34 Trisubstituted alkene substrates can be hydrogenated wit

35 effects, determined the configuration of the trisubstituted alkene target.

36 llylic alcohol products with a stereodefined trisubstituted alkene unit.

37 yl sulfone affords the construction of the Z-trisubstituted alkene with high efficiency and stereosel

38 ting groups, and delivers each nonconjugated trisubstituted alkene with high levels of stereoselectio

39 ed homoallylic alcohols with a stereodefined trisubstituted alkene.

40 struct organic luminophores and a deuterated trisubstituted alkene.

41 ult; hence, it would be favorable to use the trisubstituted alkene.

42 nergy differences between E and Z isomers of trisubstituted alkenes (compared with 1,2-disubstituted

43 substrate for the same product, the isomeric trisubstituted alkenes (D in the text).

44 chiral homoallylic amines possessing di- or trisubstituted alkenes and anti- or syn- relative stereo

45 s-metathesis reactions that generate Z- or E-trisubstituted alkenes are disclosed.

46 Rhodium-catalyzed hydroborations of trisubstituted alkenes are generally slow and often suff

47 ver, except for the intramolecular coupling, trisubstituted alkenes are unsatisfactory coupling partn

48 glycolatoboryl) promote the hydrogenation of trisubstituted alkenes by enabling irreversible alpha-bo

49 otherwise difficult-to-access linear E- or Z-trisubstituted alkenes can be synthesized efficiently an

50 nantioselectively, and ones that can produce trisubstituted alkenes diastereoselectively, are central

51 or the stereoselective generation of acyclic trisubstituted alkenes in either the E or the Z isomeric

52 This is accomplished by the use of di- or trisubstituted alkenes in stereoretentive processes, whi

53 Stereoselective synthesis of trisubstituted alkenes is a long-standing challenge in o

54 ated monosubstituted, 1,1-disubstituted, and trisubstituted alkenes is disclosed.

55 tioselective boronate conjugate additions to trisubstituted alkenes of acyclic alpha,beta-unsaturated

56 containing regio- and stereodefined di- and trisubstituted alkenes of all conceivable types will be

57 rmolecular dehydrogenative Heck arylation of trisubstituted alkenes to construct remote quaternary st

58 ed monoterpenoid alcohols with various other trisubstituted alkenes to form new trisubstituted olefin

59 ubstituted, (Z)-1,2-disubstituted, and 1,1,2-trisubstituted alkenes undergo dihydroxylation with anti

60 ion of more hindered internal and endocyclic trisubstituted alkenes was achieved through hydroxyl gro

61 ctions may be performed on the corresponding trisubstituted alkenes, affording quaternary carbon ster

62 enes can serve as an alternative approach to trisubstituted alkenes, but it remains underdeveloped ow

63 s to carboxylic acids derived from beta,beta-trisubstituted alkenes, in a highly regioselective manne

64 nyl phosphorus compounds, and in the case of trisubstituted alkenes, regio- and stereocontrolled olef

65 ners giving rise to the corresponding di- or trisubstituted alkenes, typically in high yield and with

66 phatic and aromatic imines, allylic silanes, trisubstituted alkenes, vinyl- and aryl halides, trifluo

67 cross-metathesis reactions involving E- or Z-trisubstituted alkenes, which are easily prepared from c

68 cyclic systems, to furnish disubstituted and trisubstituted alkenes.

69 o the formation of skipped dienes containing trisubstituted alkenes.

70 rious combinations of indole derivatives and trisubstituted alkenes.

71 resulting in a general synthetic strategy to trisubstituted alkenes.

72 e couplings, providing an efficient route to trisubstituted alkenes.

73 method is compatible with terminal, di-, and trisubstituted alkenes.

74 protodeboronation with TBAF3 H(2)O to give Z-trisubstituted alkenes.

75 ion reaction of a variety of mono-, di-, and trisubstituted alkenes.

76 d stereoselective access to a broad range of trisubstituted alkenes.

77 ieve otherwise challenging hydrogenations of trisubstituted alkenes.

78 and diastereoselective synthesis of complex trisubstituted alkenes.

79 action between alkenyl triflates and acyclic trisubstituted alkenols of varying chain-lengths.

80 ive redox-relay Heck alkynylation of di- and trisubstituted alkenols to construct propargylic stereoc

81 e synthesis of allylic boronates bearing a Z-trisubstituted alkenyl fluoride is disclosed.

82 For cyclopropanes bearing a trisubstituted alkenyl group either the corresponding cy

83 bstituted alkenyl-, acyclic, or heterocyclic trisubstituted alkenyl groups may be added in up to >98%

84 lenes were converted to products bearing a Z-trisubstituted alkenyl-B(pin) moiety, a vinyl group, a b

85 lective intermolecular Heck-type reaction of trisubstituted-alkenyl alcohols with aryl boronic acids.

86 uted alkene and an easily functionalizable Z-trisubstituted alkenylboron group, are obtained in up to

87 ere subtly tuned to form either a primary or trisubstituted alkyl complex as the more thermodynamical

88 An X-ray crystal structure of the trisubstituted alkyl-palladium complex is presented and

89 reospecific amine-catalyzed isomerization to trisubstituted allenes (see picture; NHC = N-heterocycli

90 re compatible with various 1,1-di- and 1,1,3-trisubstituted allenes and N-hydroxyaniline derivatives.

91 The efficient hydroformylation of 1,1,3-trisubstituted allenes is accomplished with low loadings

92 e transfer of chirality was obtained for all trisubstituted allenes, but loss of chiral information w

93 pounds and terminal alkynes provides di- and trisubstituted allenes.

94 All-catalytic route to trisubstituted allenes: The first examples of catalytic

95 What is more, Z-trisubstituted allyl boronates may be used.

96 In the case of trisubstituted allylboronates with different substituent

97 % of a Ru catechothiolate complex and afford trisubstituted allylic alcohols and ethers in up to 81%

98 od for the synthesis of (Z)-alpha,alpha,beta-trisubstituted allylic alcohols.

99 ated isomerization process that gives di- or trisubstituted allylic boronic esters with high E select

100 alkyl- (linear as well as branched) and aryl-trisubstituted allylic carbonates serve as effective sub

101 Ir-catalyzed enantioselective allylation of trisubstituted allylic electrophiles has been developed.

102 roup of allylic electrophiles, we found that trisubstituted allylic phosphates are suitable electroph

103 electively capture these intermediates, both trisubstituted alpha,beta-unsaturated esters, beta-indol

104 rated [Pd-H] was demonstrated using isomeric trisubstituted alpha,beta-unsaturated esters.

105 lates to afford alpha-tetrasubstituted, beta-trisubstituted alpha-amino acids (generally >20:1 dr) is

106 to provide facile access to highly hindered trisubstituted alpha-branched olefins, which when couple

107 -Michael addition reaction of aryl thiols to trisubstituted alpha-fluoro-alpha,beta-unsaturated ester

108 oroki-Heck reaction allowed the formation of trisubstituted alpha-trifluoromethylacrylates.

109 ctical, catalytic entry to alpha,alpha,alpha-trisubstituted (alpha-tertiary) primary amines by C-H fu

110 ities were tolerated at this position, alpha-trisubstituted amines possessed markedly decreased inhib

111 pha,beta-disubstituted, or alpha,beta,alpha'-trisubstituted amines.

112 ecular aminohydroxylations of functionalized trisubstituted and 1,1-disubstituted alkenes employing b

113 oamidation and iodo-imidation of ynamides to trisubstituted and tetrasubstituted ketene aminals is ex

114 zed dialkylzincs, and (E)-disubstituted, (E)-trisubstituted, and (Z)-disubstituted vinylzinc reagents

115 itrogen-substituted terminal, disubstituted, trisubstituted, and cyclic alkenes reacted to afford the

116 and seeds, mainly based on the proportion of trisubstituted anthocyanin derivatives, flavonols and fl

117 Various olefins, mono-, di-, and trisubstituted, are epoxidized chemoselectively in high

118 tive coupling of 1,3-disubstituted and 1,2,3-trisubstituted arenes (aryl-H) with cyclometalating subs

119 n and cyanation, 1,3-disubstituted and 1,2,3-trisubstituted arenes and heteroarenes containing halide

120 Mono-, di-, and trisubstituted arenes lacking a directing group undergo

121 ly versatile and nicely differentiated 1,2,3-trisubstituted arenes that are difficult to access by ot

122 s and selectivities, especially with di- and trisubstituted arenes.

123 2,2,3-Trisubstituted aziridines are known to undergo ring open

124 the direct asymmetric catalytic synthesis of trisubstituted aziridines from imines and diazo compound

125 and alpha-diazo-N-acyloxazolidinones to give trisubstituted aziridines with excellent diastereo- and

126 Several trisubstituted aziridines, with different substitution p

127 and enantioselective construction of complex trisubstituted aziridines.

128 ed a short, general synthetic route to 1,3,6-trisubstituted azulenes.

129 d diynes under cobalt-catalysis led to 1,2,3-trisubstituted benzene derivatives in good yields.

130 yptands based on 1,3-dioxane decorated 1,3,5-trisubstituted-benzene building blocks, connected by dif

131 wing up the identification of two lead 2,5,6-trisubstituted benzimidazoles, 1 and 2, targeting Mtb-Ft

132 lpha-tripeptides comprising a central chiral trisubstituted beta(2,2,3)*-amino acid residue form unus

133 esign combines (ortho-tolyl)amide and o,o,o'-trisubstituted biphenyl structural units to provide a ge

134 s in formation of a completely unsymmetrical trisubstituted BODIPY.

135 s-coupling reactions to give mono-, di-, and trisubstituted bullvalenes.

136 a set of cobalt(III)-complexes equipped with trisubstituted chiral cyclopentadienyl ligands is report

137 rocyclic biaryl ether core incorporating two trisubstituted chloroalkenes at its periphery.

138 The 2,3-trans, 2,4-cis trisubstituted chroman moiety was formed via highly effi

139 nic as it is made of a thallium cation and a trisubstituted cluster anion.

140 a small and representative library of 3,5,8-trisubstituted coumarins (21 compounds, 7 families, 3 gr

141 nters involves a decarbonylative coupling of trisubstituted cyclic olefins and benzocyclobutenones th

142 The pharmaceutically relevant 1,1,3-trisubstituted cyclobutane products are decorated with a

143 A chiral trisubstituted cyclobutane was efficiently synthesized f

144 boxamides and the syntheses of several novel trisubstituted cyclobutanecarboxamide scaffolds having a

145 ully employed to form a diverse set of 1,1,3-trisubstituted cyclobutanes (>50 examples) with high dia

146 oselective (ee value up to 98%) synthesis of trisubstituted cyclohexanols was achieved by using a tan

147 nics was also demonstrated for a diene and a trisubstituted cyclohexene.

148 The trisubstituted cyclohexenone 12, generated through a pal

149 Reductive cyclization of the 2,4,5-trisubstituted cyclohexenone 16 using dihydogen in the p

150 We have found that 1,1,2-trisubstituted cyclopent-3-enes were exclusively obtaine

151 A trisubstituted cyclopentane chiron has been prepared by

152 nthesis of spiro(cyclopentene)oxindoles with trisubstituted cyclopentene units.

153 ative catalysis provides access to cis-1,3,4-trisubstituted cyclopentenes from enals and chalcone der

154 th a concise stereocontrolled preparation of trisubstituted cyclopentenes.

155 synthesis of either diastereomer of di- and trisubstituted cyclopropanes.

156 ivity in the cycloisomerization of enynes to trisubstituted cyclopropanes.

157 s, enesulfones, and enamides to afford 1,2,3-trisubstituted cyclopropanes.

158 aborated to furnish a variety of enantiopure trisubstituted cyclopropanes.

159 aborated to furnish a variety of enantiopure trisubstituted cyclopropanes.

160 These trisubstituted diarylcyclopropanehydroxamic acids were d

161 f the synthesis required the instalment of a trisubstituted double bond by radical deoxygenation.

162 d C, we have discovered the formation of a Z-trisubstituted double bond.

163 upling strategy was utilized to assemble the trisubstituted (E,E)-diene.

164 oped to access either (E)- or (Z)-isomers of trisubstituted enamides.

165 The catalytic asymmetric hydrogenation of trisubstituted enol esters using Rh catalysts bearing ch

166 ion leading to N-heterocycles via control of trisubstituted enolate intermediates.

167 akes place at room temperature and affords E-trisubstituted enones in moderate to good yields with hi

168 problem of ECA of alkenyl groups to acyclic trisubstituted enones, an advance achieved by adopting a

169 based on an early stage introduction of the trisubstituted epoxide group is reported, allowing acces

170 s demonstrated using four diastereomers of a trisubstituted epoxide.

171 d oxepane-containing polyethers from di- and trisubstituted epoxides.

172 ure described for the formation of the 2,3,5-trisubstituted furan (option B) takes approximately 52.5

173 saturated alcohol and formation of the 2,3,5-trisubstituted furan adduct.

174 enones to deliver products featuring a 2,3,5-trisubstituted furan bearing a fused cyclopropyl substit

175 of this gamma-hydroxyenone to afford a 2,3,5-trisubstituted furan.

176 eses of various aromatic and aliphatic 2,3,5-trisubstituted furans from acetylenic epoxides are descr

177 ogates, allowing facile preparation of 2,3,5-trisubstituted furans, pyrroles, and thiophenes.

178 siloxy-2,3-dihydrofuran derivatives or 2,3,5-trisubstituted furans, respectively, under mild conditio

179 Herein, we report that trisubstituted haloimidazoles not only display ferroelec

180 -alkylation at position 1 afforded the 1,7,7-trisubstituted hexahydropyrazolo[1,5-a]pyridin-2(1H)-one

181 catalyzed aminations which transform di- and trisubstituted homoallylic carbamates into [4.1.0]-carba

182 lective hydrogenation of enantioenriched (E)-trisubstituted hydroxy enamines to generate 1,2-disubsti

183 ynthesis of 10-aza-9-oxakalkitoxin, an N,N,O-trisubstituted hydroxylamine-based analog, or hydroxalog

184 tetrahydrofuran at 0 degrees C to give N,N,O-trisubstituted hydroxylamines suitable for medicinal che

185 , we determined the binding modes of several trisubstituted imidazole inhibitors in complex with the

186 Previous studies of trisubstituted imidazole inhibitors led to the serendipi

187 p53-MDM2/MDMX inhibitors based on the 1,4,5-trisubstituted imidazole scaffold which are appended wit

188 upling with haloarenes furnished the desired trisubstituted imidazole scaffolds.

189 a subsequent two-fold cross-coupling to give trisubstituted imidazoles in good yields.

190 of the resulting alpha-hydroxyiminoimines to trisubstituted imidazoles in high yields under mild cond

191 We have prepared a set of trisubstituted imidazoles with a rigidized 7-azaindole h

192 reoselective synthesis of a variety of 1,2,3-trisubstituted indoles having a Z configuration of the (

193 n trisubstituted styryl azides to form 1,2,3-trisubstituted indoles.

194 rther extended to the preparation of a 1,2,3-trisubstituted indoline.

195 ctor of the cembranoid skeleton containing a trisubstituted iodoalkene attached to an alpha-phenylsel

196 an internal alkyne for the preparation of a trisubstituted iodoalkene, allene formation using the My

197 benzothiazole carboxylic acid moiety onto a trisubstituted isoxazole scaffold.

198 A variety of trisubstituted isoxazoles are prepared in moderate to ex

199 ses the yield of the desired 4-alkenyl-3,4,5-trisubstituted isoxazoles.

200 actions, and the preparation of chiral 3,4,4-trisubstituted isoxazolines.

201 Enantioenriched trisubstituted lactones were obtained in good yields and

202 Mono-, di- and trisubstituted lanthanide amidinate and guanidinate comp

203 ations open the potential for asymmetric and trisubstituted linkages projecting from the sulfur(VI) c

204 K4Ge9 with {Si(SiMe3)3}Cl which produces the trisubstituted monoanions [Ge9{Si(SiMe3)3}](-).

205 ransferase inhibitor, which contains a 2,6,6-trisubstituted morpholine system, can be accomplished.

206 oped small-molecule G-quadruplex ligand, the trisubstituted naphthalene diimide compound CM03, has pr

207 zuki coupling in the imidazole ring to yield trisubstituted NH-imidazoles (23%-69%, three steps).

208 novo palladium carbon-catalyzed synthesis of trisubstituted nicotinonitriles from easily synthesized

209 ive addition to and nitronate protonation of trisubstituted nitroalkenes to produce highly enantioenr

210 Here, a novel class of ANPs containing trisubstituted nitrogen (aza-ANPs) has been synthesized.

211 silyl)vinyl substituent to produce the 3,5,7-trisubstituted octahydro[2]pyrindene as a single diaster

212 ethyl allylmethylallylmalonate) that forms a trisubstituted olefin product is used to further delinea

213 ough carboacylation of a sterically hindered trisubstituted olefin with benzocyclobutenone.

214 A catalytic asymmetric bromocyclization of trisubstituted olefinic amides that uses a C(2)-symmetri

215 catalyst in the hydrogenation of unactivated trisubstituted olefins and superior activity in the hydr

216 A range of mono-, di-, and trisubstituted olefins as well as alkyl- and arylthioami

217 tions, selective hydrogenation of one of two trisubstituted olefins can be achieved.

218 Furthermore, trisubstituted olefins can be selectively hydrogenated i

219 zed for the cross-metathesis of pre-existing trisubstituted olefins in other relay-actuated Delta(6,7

220 ave been obtained for a variety of trans and trisubstituted olefins including electron-deficient alph

221 with pendant 1,2-disubstituted olefins form trisubstituted olefins with control of both absolute con

222 array of olefins, including mono-, di-, and trisubstituted olefins, are all smoothly hydromethylated

223 tes allowed the stereoselective synthesis of trisubstituted olefins, while allylic substitution of th

224 ous other trisubstituted alkenes to form new trisubstituted olefins.

225 s for the syntheses of geometrically defined trisubstituted olefins.

226 A series of various di- and trisubstituted oxazole products bearing different append

227 ated cyclization of enamides to afford 2,4,5-trisubstituted oxazoles.

228 etric cyclizations of acyclic ketone-derived trisubstituted oxocarbenium ions, thereby providing acce

229 In almost all cases the 2,3,5-trisubstituted p-benzoquinones were obtained.

230 This base induced reaction of 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazo

231 Trisubstituted perfluoroalkenes can be obtained in a hig

232 ch is also applied to the synthesis of 2,3,4-trisubstituted phenols.

233 rans-quinolizidine (+)-myrtine and cis-2,4,6-trisubstituted piperidine alkaloid (+)-241D are reported

234 n of a potential drug candidate containing a trisubstituted piperidine moiety.

235 d by tributyltin hydride to afford the 2,4,5-trisubstituted piperidine or undergo a second 5-endo cyc

236 Further structural modifications on the trisubstituted piperidine scaffold of 11i yielded compou

237 eral and efficient method to construct 2,3,6-trisubstituted piperidines in a substituent-independent

238 A novel approach to 2,4,5-trisubstituted piperidines is reported, involving the 6-

239 rectly converted to the diastereomeric 2,4,5-trisubstituted piperidines syn-5m, -5n, -5o and anti-5m,

240 arylation of very hindered alpha,alpha,alpha-trisubstituted primary amines.

241 native synthetic approach for selected 2,6,9-trisubstituted purine CDK inhibitor conjugates with foli

242 (R)-Roscovitine, a trisubstituted purine, has been shown to inhibit L-curre

243 xanedione also promoted the formation of key trisubstituted pyrazines.

244 The synthesis of 3,4,5-trisubstituted pyrazoles via a tandem catalytic cross-co

245 In the present study, we introduce 1,3,5-trisubstituted pyrazolines as potent and selective allos

246 rt the discovery and optimization of a 3,4,5-trisubstituted pyridine 9 using a high-throughput cell-b

247 ition between two dehydroalanines to forge a trisubstituted pyridine core.

248 al alkynes and a cyanamide to afford a 2,4,6-trisubstituted pyridine product regioselectively.

249 Acids to bases: The synthesis of 2,4,6-trisubstituted pyridines from (phenylthio)acetic acid an

250 report an efficient means to access di- and trisubstituted pyridines in an efficient and highly cont

251 l access to various previously unknown 2,3,6-trisubstituted pyridines.

252 tions yielded the synthesis of 4-amino-2,6,8-trisubstituted pyrido[3,2-d]pyrimidine derivatives, with

253 it against Plasmodium falciparum, based on a trisubstituted pyrimidine scaffold.

254 curs prior to enolization to produce a 2,3,5-trisubstituted pyrrole after cyclization.

255 lude single-step access to the central 1,2,4-trisubstituted pyrrole core in a highly regioselective m

256 by a Paal-Knorr cyclization provides a 2,3,4-trisubstituted pyrrole; when enolization is disfavored,

257 regioselective synthesis of 2,3,4- or 2,3,5-trisubstituted pyrroles has been achieved via [3,3] and

258 ion sequence to preferentially furnish 1,2,4-trisubstituted pyrroles instead of the expected 1,2,3-tr

259 thod allows the synthesis of mono-, di-, and trisubstituted pyrroles with appropriate substitutions.

260 tuted pyrroles instead of the expected 1,2,3-trisubstituted pyrroles, in good to excellent yields.

261 minals, followed by ring opening to generate trisubstituted pyrroles.

262 ed for the regioselective synthesis of 1,2,4-trisubstituted pyrroles.

263 es for the oxidative synthesis of penta- and trisubstituted pyrroles: a nitrenoid analogue to classic

264 potency and pharmacokinetic profile of 2,3,4-trisubstituted quinoline, 4, led to the discovery of two

265 a novel "four-blade propeller" shaped 1,2,3-trisubstituted quinolizinone 34.

266 2,6-Disubstituted pyridines and 2,6,7-trisubstituted quinuclidines are screened as potential s

267 The selectivity change for the trisubstituted rings is attributed to a distortion of th

268 crossover reactions of internal olefins via trisubstituted ruthenacyclobutane intermediates.

269 We report a tunable library of N,N,N'-trisubstituted selenourea precursors and their reaction

270 te the selective migration of acyl groups in trisubstituted styryl azides to form 1,2,3-trisubstitute

271 with anti-diastereoselectivity, while 1,2,2-trisubstituted systems afford syn-diastereoisomers.

272 tem shows ortho selectivity, while the 1,3,4-trisubstituted systems show para, meta (instead of ortho

273 d substrate scope, including mono-, di-, and trisubstituted tertiary, secondary, and primary anilines

274 tereoselectivity with which terminal di- and trisubstituted tetraenes are known to react biosynthetic

275 potentially diastereoselective, and di- and trisubstituted tetraenes often undergo cascade reactions

276 Computations indicate that di- and trisubstituted tetraenes undergo facile but less exergon

277 ved in the Pictet-Spengler reaction of 1,2,3-trisubstituted tetrahydro-beta-carbolines.

278 An oxonium ylide rearrangement formed the trisubstituted tetrahydrofuran core found in the natural

279 The enantioselective synthesis of 2,3,5-trisubstituted tetrahydrofurans 3 has been achieved usin

280 nthesis of complex stereocomplementary 1,3,4-trisubstituted tetrahydroisoquinolines (THIQs) with thre

281 ariety of 2,6-disubstituted as well as 2,4,6-trisubstituted tetrahydropyrans that could be considered

282 y have been achieved in a synthesis of 2,4,5-trisubstituted tetrahydropyrans, which proceeds under th

283 thieno[3,2-b]pyrroles and the discovery of a trisubstituted thieno[3,2-b]pyrrole 5-carboxamide 15c th

284 Some 1,4,5-trisubstituted triazole carboxamides induced dramatic de

285 aryl propiolates gave a new family of 1,4,5-trisubstituted triazole carboxylic acid derivatives that

286 ed 1,4-disubstituted triazoles, 5-iodo-1,4,5-trisubstituted triazoles, and 5-alkynylated 1,4,5-trisub

287 ange of organic azides to afford enantiopure trisubstituted triazoles.

288 bstituted triazoles, and 5-alkynylated 1,4,5-trisubstituted triazoles.

289 nthesis of unsymmetrical N,N'-di- and N,N,N'-trisubstituted ureas in one pot and is tolerant of a wid

290 The insertion of trisubstituted ureas in the main chain of N,N'-linked ol

291 ymmetrical and symmetrical disubstituted and trisubstituted ureas utilizing 2-chloropyridine and trif

292 also yielded a stereoselective synthesis of trisubstituted vinyl aziridines from these chiral sulfin

293 The trisubstituted vinyl boronate esters are formed as the (

294 ds to the formation of 1,1-disubstituted and trisubstituted vinyl boronate esters with moderate to go

295 ynes is also achieved using BCl3 to generate trisubstituted vinyl boronate esters.

296 of electron rich alkynes reveals stabilized trisubstituted vinyl cation equivalents that react with

297 This methodology allows preparation of trisubstituted vinyl ethers with excellent stereospecifi

298 whereas the cis-disubstituted and the trans-trisubstituted vinylepoxide linchpins proceed to deliver

299 complished with palladium NHC catalysts, and trisubstituted Z alkenylsilanes are accessed with nickel

300 What is more, trisubstituted Z-alkenyl chloride moiety can be accessed