ライフサイエンスコーパス: tritium

1 vity 50 microCi/micromol for the transferred tritium).

2 choline and measuring 5-HT-evoked release of tritium.

3 form readily in the presence of nitrogen and tritium.

4 t energy source from a facility that handles tritium.

5 ganic compounds (VOCs), pharmaceuticals, and tritium.

6 ikely origin, location, and phases that trap tritium.

7 clear fusion reactions between deuterium and tritium.

8 f Nav1.7 blockers has been radiolabeled with tritium.

9 oncentrations of other radionuclides such as tritium, (14)C, or (85)Kr will become blurred in the sig

10 ic composition (delta(13)C-CH4), groundwater tritium ((3)H) and dissolved organic carbon (DOC) concen

11 Tritium ((3)H) is produced in nuclear reactors via sever

12 e relative ease and low cost associated with tritium ((3)H) make it an ideal radioisotope with which

13 for the synthesis of deuterium ((2)H, D) and tritium ((3)H, T) labelled analogues have remained elusi

14 f glyceroneogenesis was quantified using the tritium ([(3)H(2)]O) labeling of body water, and the con

15 After radiolabeling with tritium, [(3)H]BIO-735 and [(3)H]BIO-578 binding in rode

16 accurately and reproducibly for analysis of tritium (3H) content by accelerator mass spectrometry (A

17 nt assay and amino acid transport assayed by tritium (3H)-labeled amino acid uptake.

18 carbon-14 (14C) and the conjugated drug with tritium (3H).

19 hich the terminal hydroxyl was replaced with tritium ([3H]-sT-CoA).

20 rements for impurity removal and recovery of tritium, a silver-coated optical or waveguide is employe

21 ellular membrane fractions revealed that the tritium accumulation observed in the caveolin-rich membr

22 iments with normal acetone did not result in tritium activity or neutron emissions.

23 soralen exhibited a 4- to 7-fold increase in tritium activity relative to untreated controls.

24 A tritium-adenine suicide procedure was used to select for

25 Tritium, an indicator of infiltration and surface water

26 d method for late-stage installation of both tritium and carbon-11 into the desired compounds via met

27 Both tritium and carbon-11 radioisotopologues are generally n

28 t and then coupled to either methotrexate or tritium and either fluorescein or 6-carboxytetramethylrh

29 on region geometries and ionization sources, tritium and nickel-63.

30 atural recharge successfully predicted plume tritium and nitrate concentrations.

31 mixing model was developed to predict plume tritium and nitrate concentrations.

32 exane (trans-NPCO-DSC) was radiolabeled with tritium, and its binding characteristics to K(v)1.3 chan

33 Radioactivity from radioiodine, tritium, and uranium is not expected to create a signifi

34 Controlled amounts of liquid tritium are discharged as tritiated water (HTO) by the n

35 beled with the radioisotopes fluorine-18 and tritium, as well as a fluorescent tag.

36 ly adaptable for the facile incorporation of tritium at C-4 of the diphosphate.

37 potency, a suitable photoreactive group, and tritium at high specific activity.

38 VUF15485 labeled with tritium at one of its methoxy groups ([(3)H]VUF15485), b

39 L-Proline labeled with deuterium or tritium at the diastereotopic C-5 methylene loci was sho

40 ange or selective retention of deuterium (or tritium) at the level of the triose-isomerase reaction o

41 holoenzyme bound approximately 2-3 atoms of tritium/atom of C-14.

42 of the gaseous extract is transferred to the tritium-based ion source of a drift-tube ion mobility sp

43 ATRIN performs precision spectroscopy of the tritium beta-decay close to the kinematic endpoint.

44 DT fusion, neutrino mass measurements using tritium beta-decay or photonuclear experiments where HD

45 The kinetics of the turnover of tritium between seawater HTO, biota HTO, and OBT was inv

46 been used to investigate the partitioning of tritium between substrate and product in the reaction ca

47 2-ketoglutarate undergoes rapid exchange of tritium between the 5'-position of the coenzyme and C-4

48 whole-organism OBT is a slow process with a tritium biological half-life on the order of months.

49 The weakly bound form of tritium can be liberated at significantly lower temperat

50 Without an appreciation that two forms of tritium can exist in reactor bioshields, the (3)H conten

51 In irradiated metals, an additional type of tritium can form internally through neutron capture reac

52 ing a backbone hydrogen atom in glucose with tritium can significantly increase or decrease the equil

53 Despite the improved tritium chemical shift dispersion, this method is not us

54 Concentrations of tritium, chloride, sulfate, DOC, and manganese + iron; p

55 rom the end of 2013 to 2019, with an average tritium concentration of approximately 20 Bq/L.

56 57 chemical and land-use variables show that tritium concentration, distance to the nearest fire-trai

57 t random forest regression models to predict tritium concentrations from microbial family relative ab

58 Tritium concentrations measured in seawater HTO, as well

59 The most important families for predicting tritium concentrations were Nitrosopumilaceae and Methyl

60 s allows the prediction of selectivities for tritium-containing isotopologues.

61 e in the steady state leads to protein-bound tritium corresponding to 11% of the active sites.

62 Based on tritium data published by Tokyo Electric Power Company H

63 itation experiments with deuterated acetone, tritium decay activity above background levels was detec

64 ssed annually for heavy-water production and tritium decontamination.

65 Labeled tritium dilution and total-body potassium were used to e

66 of thigh sections, total body potassium, and tritium dilution techniques were used to measure increas

67 owledged that the radiological impact of the tritium discharges into the Estuary was small, public co

68 ger (DPI) was used with a portable deuterium-tritium (DT) neutron generator to detect neutrons and ga

69 An observed tritium effect upon V/K for reduction of dihydrofolate a

70 esaturase and the development of an in vitro tritium efficacy radioassay.

71 This externally derived tritium enters metals by diffusion with a rate controlle

72 The pattern of tritium evolution derived from simple thermal desorption

73 in using photoaffinity labeling and hydrogen-tritium exchange (HX).

74 ins, BSA and myoglobin (MGB), using hydrogen-tritium exchange and light scattering.

75 Tritium exchange from solvent into pyruvate is catalyzed

76 ircular dichroism spectroscopy, and hydrogen-tritium exchange measurements to study the effect of the

77 th those determined by (1)H NMR and hydrogen-tritium exchange methods.

78 ethylADP is a very effective promoter of the tritium exchange reaction between [5'-3H2]adenosylcobala

79 We measured the tritium exchange reaction on cytosine C(5) in the presen

80 arlier highly accurate but much more limited tritium exchange results, extend the analysis to the ent

81 lie anesthetic actions, analysis of hydrogen/tritium exchange was used to measure effects on the stab

82 By tritium exchange, Tbeta(4) slows the exchange rate of ap

83 the "classical" mechanism, 98% of the pro-R tritium exchanges with solvent from Glu-165 at the inter

84 mately depends on the metal composition, its tritium exposure history, integrated neutron flux, sampl

85 ff from multiple sources associated with the Tritium Facility at the DOE-Savannah River Site, Aiken,

86 tions are suitable for compressing deuterium-tritium-filled capsules, with the goal of achieving burn

87 linking experiments analyzed by SDS-PAGE and tritium fluorography have identified a approximately 160

88 g step may be altered by the substitution of tritium for hydrogen in the reaction.

89 Methods for tagging bile acids with tritium for metabolic or transport studies are summarize

90 0-900 degrees C is indicative of neutrogenic tritium formed via neutron capture by trace Li and B.

91 ere analyzed following addition of 2 mg of a tritium-free-hydrogen carrier.

92 adicals is rapid relative to the transfer of tritium from 5'-deoxyadenosine to either substrate or pr

93 determined for the ALAS-catalyzed removal of tritium from [2-(3)H(2)]glycine.

94 ereas the wild-type enzyme catalyzes loss of tritium from [2-3H2]-glycine, mutation of K313 to glycin

95 leotide reduction, catalyzes the exchange of tritium from [5'-3H]-AdoCbl with solvent.

96 tritium isotope effects for the transfer of tritium from adenosylcobalamin to product in each direct

97 TIM reaction, approximately 2% of the pro-R tritium from C1 of DHAP is conserved and appears at C2 o

98 duction of pure deuterium and the removal of tritium from nuclear waste are the key challenges in sep

99 t the center that contains the deuterium and tritium fuel.

100 apping' required to accelerate the deuterium-tritium fusion burn to eventually 'run away' and ignite.

101 mount of energy deposited into the deuterium-tritium fusion fuel and hotspot during the implosion pro

102 euticals by hydrogen isotope exchange, using tritium gas as the source of the radioisotope.

103 tion of a hexenyl-substituted precursor with tritium gas.

104 There has been tritium groundwater leakage to the land side of Fukushim

105 ction frequency was 2.6% in groundwater with tritium >/=1 pCi/L, depth <30 m, and anoxic conditions.

106 l and copper), it was found that significant tritium had become incorporated following prolonged expo

107 ntium isotope ratios, along with groundwater tritium-helium and radiogenic (4)He in-growth age-dating

108 e river was 1.3 +/- 0.8 years, determined by tritium-helium dating.

109 d exposure to tritiated water vapor (HTO) or tritium/hydrogen gas (HT) in nuclear facilities.

110 ent in yield performance over past deuterium-tritium implosion experiments.

111 d to the high incorporation of deuterium and tritium in 18 drug molecules, which meet the requirement

112 e four soman diastereomers, all labeled with tritium in Calpha.

113 nsiderable concerns about the measurement of tritium in isotope separation and radiological impuritie

114 ipeptide dolastatin 15 was radiolabeled with tritium in its amino-terminal dolavaline residue.

115 derstanding the association and retention of tritium in metals has significance in nuclear decommissi

116 gh levels of FAAH, showed an accumulation of tritium in the caveolin-rich membrane fraction only when

117 etabolism blocked the observed enrichment of tritium in the caveolin-rich membranes.

118 y RBL-2H3 cells, we found an accumulation of tritium in the caveolin-rich membranes.

119 ) gas leads to incorporation of deuterium or tritium in the dihydrogen ligand.

120 used to determine the depth distribution of tritium in the tracheal mucosa.

121 ified prebeta-1 HDL, labeled covalently with tritium, in plasma samples, to label the prebeta-1 HDL p

122 ting heavier hydrogen isotopes-deuterium and tritium-in therapeutic molecules, most established metho

123 Tritium, incorporated into the proteins, was quantitated

124 In contrast, tritium incorporation experiments with purified carboxyl

125 hiol groups of Keap1 have been determined by tritium incorporation from [(3)H]dexamethasone mesylate

126 an accommodate the classical measurements of tritium incorporation from DHAP into GAP.

127 Introduction of 1 mole-atom of tritium into aldehyde 5b was required during radioligand

128 Using phospholipase D, we incorporated tritium into each analogue.

129 inhibition of catalysis and incorporation of tritium into the enzyme.

130 onsists of a compact 44 mm drift tube with a tritium ionization source and a resolving power of 70.

131 and a 2 mm reaction region, sufficient for a tritium ionization source.

132 fusion reactor a hot plasma of deuterium and tritium is confined by a strong magnetic field to produc

133 The tritium is normally trapped in hydrated oxides lying alo

134 This intramolecular transfer of tritium is therefore predicted to be independent of DHAP

135 ch techniques to measure the alpha-secondary tritium isotope effect associated with the formation of

136 Specifically, the equilibrium tritium isotope effects are 1.027 +/- 0.002, 0.927 +/- 0

137 y measurements have been used to measure the tritium isotope effects for the transfer of tritium from

138 ve deuterium isotope effects and competitive tritium isotope effects leads to the conclusion that the

139 We have utilized tritium isotope effects to probe the in vitro binding eq

140 ch techniques to measure the alpha-secondary tritium kinetic and equilibrium isotope effects associat

141 te synthase is demonstrated by measuring the tritium kinetic isotope effect on the enzyme's second or

142 the substrate pair, inverse alpha-secondary tritium kinetic isotope effects are observed, and a Swai

143 The alpha-secondary tritium kinetic isotope effects are reduced to values ne

144 The alpha-secondary tritium kinetic isotope effects are slightly higher than

145 The calculated deuterium and tritium kinetic isotope effects for the overall rate agr

146 Alpha-secondary tritium kinetic isotope effects were measured with NAD+

147 sequencing of the labeled peptide, only the tritium label was in evidence at C221, with a stoichiome

148 -S hydrogen at C-13 (3-9% retention of pro-S tritium label), the same stereoselectivity as in the for

149 Tritium labeled FK506 (FK) was used to identify and quan

150 assays to measure lymphocyte proliferation (tritium labeled thymidine incorporation and flow cytomet

151 sing the Twin-Strep protein affinity tag and tritium-labeled (3H)Strep-TactinXT probe.

152 n homogenates were measured in vitro against tritium-labeled 6 (Pittsburgh compound B).

153 Compound 6b was demonstrated to be >/=95% tritium-labeled at the imine position by NMR spectroscop

154 for analytical mass spectrometry, the use of tritium-labeled compounds is a key technique all along d

155 abeling methods to synthesize deuterium- and tritium-labeled compounds.

156 Using a tritium-labeled FA in batch experiments made it possible

157 hexylamino-2,4(1H,3H)-pyrimidinedione (6) in tritium-labeled form ([(3)H]PSB-1584) by hydrogenation o

158 omene-2-carboxylic acid (12) was obtained in tritium-labeled form, designated [(3)H]PSB-13253, with a

159 ymatic preparation of high-specific-activity tritium-labeled Fru-2,6-P(2).

160 charides, the solubilized fraction contained tritium-labeled high molecular weight material.

161 A tritium-labeled isotopomer (18.8 Ci/mmol) of this nonter

162 The tritium-labeled JNJ-63533054 bound to cell membranes exp

163 ion of ester 3 with custom synthesized, 100% tritium-labeled lithium triethylborotritide, followed by

164 Incubation of tritium-labeled lysosomes with phagosomes containing sci

165 Laboratory experiments with tritium-labeled methane have been conducted to help dete

166 ween the biodistribution determined by using tritium-labeled particles and that using optical imaging

167 oproteins gave rise to an approximate 10 kDa tritium-labeled peptide, each of which was a distinct po

168 Deuterium- and tritium-labeled pharmaceutical compounds are pivotal dia

169 HEMA-co-SS) was established in rodents using tritium-labeled polymer.

170 n was performed on paraffin sections using a tritium-labeled probe for cathepsin G or alpha 1-PI.

171 e obtained by countercurrent distribution of tritium-labeled products and their identification by sci

172 human dermal fibroblasts were incubated with tritium-labeled psoralen without TFO to maximize detecta

173 iodistribution and tumor accumulation of the tritium-labeled PTX nanocrystals were determined immedia

174 Tritium-labeled PTX nanocrystals were further produced w

175 formerly called PAI-2), was studied by using tritium-labeled signals.

176 ntent, were specifically photolabeled with a tritium-labeled Taxol analog, 2-(m-azidobenzoyl)taxol, a

177 ation (>10-fold) of the dissociation rate of tritium-labeled THRX-160209 from M2 receptors by competi

178 For synthesis of the tritium-labeled version of this trifluoromethyldiaziriny

179 A few tritium-labeled Y(4)R ligands have been reported; howeve

180 lic hexapeptide UR-AK86C, we developed a new tritium-labeled Y(4)R radioligand ([(3)H]UR-JG102, [(3)H

181 Tritium-labelled PAI ([3H]PAI) was synthesized and used

182 rols using quantitative phosphorimaging with tritium-labelled radiotracers in conjunction with phosph

183 Based on our results, sea side and land side tritium leakage monitoring systems should be strengthene

184 Any weakly bound tritium liberated at temperatures of ~100 degrees C is i

185 Any strongly bound tritium liberated over the range of 600-900 degrees C is

186 tion frequency was 13.0% in groundwater with tritium <1 pCi/L, specific conductance >1600 muS/cm, and

187 Tritium measurements indicate that groundwater from the

188 Here we analyse thousands of US groundwater tritium measurements to show that modern groundwater ten

189 0 x 10(-15), which is equivalent to 0.02 dpm tritium/mg of material.

190 ditosylamide can be used in conjunction with tritium NMR spectroscopy to assign the configuration of

191 Despite the rapid absorption of most of the tritium, NNK was nonetheless extensively metabolized in

192 n is a quark-level analogue of the deuterium-tritium nuclear fusion reaction (DT --> (4)He n).

193 cal shift difference of these diastereotopic tritium nuclei are found to be in agreement with predict

194 between 3H and H is small, organically bound tritium (OBT) and HTO should show the same T/H ratio und

195 enic tritium (specifically organically bound tritium, OBT).

196 achidonic acids labeled with a single chiral tritium on the methylene groups at carbons 10 or 13.

197 ented here is equipped with either a 140 MBq tritium or a 95 MBq nickel-63 ionization source and cons

198 Xenopus IRBP antisense RNA, labeled with tritium or digoxigenin, was used for in situ hybridizato

199 involved reduction of the diiodofiprole with tritium, Pd/C, and triethylamine in ethyl acetate and af

200 d show how these methods can be adapted to a tritium/protium system.

201 n CO(2), and a proportional increase in both tritium release and Gla formation occurred over a range

202 However, both HPLC analysis and a tritium release assay indicated that these mutants had n

203 traditionally and most reliably assessed by tritium release end-point assays using radiolabeled coll

204 Glu deprotonation monitored by tritium release from the glutamyl gamma-carbon was depen

205 H160A showed a 10-fold lower ratio of tritium release to vitamin K epoxidation than wild-type

206 astolytic activity as assessed by a standard tritium-release assay, but, importantly, prevented the p

207 , 2, or 3 represents hydrogen, deuterium, or tritium, respectively.

208 Even higher efficiency is expected for tritium separation.

209 cinate isomers based on loss or retention of tritium showed that inversion of configuration at the me

210 Wild-type and nonglycosylated V2R yielded tritium signals at 45-55 and 40 kDa, respectively, demon

211 Tritium speciation in metals was inferred through increm

212 ic input to the estuary has been technogenic tritium (specifically organically bound tritium, OBT).

213 In this study, we have used tritium substitution and high pH to probe the glucose le

214 By chemical mutagenesis followed by a tritium suicide procedure, we obtained three conditional

215 Using tritium suicide, we have isolated a variant of the Chine

216 ly and selectively install deuterium (D) and tritium (T) at alpha-amino sp(3) carbon-hydrogen bonds i

217 Energy produced by Deuterium (D) and Tritium (T) fusion reactions, in particular in tokamaks,

218 The hydrogen isotopes deuterium (D) and tritium (T) have become essential tools in chemistry, bi

219 The fusion of deuterium (D) with tritium (T) is the most promising of the reactions that

220 of hydrogen (hydrogen -H, deuterium -D, and tritium -T).

221 the results of implosions of solid deuterium-tritium targets carried out with the 30-kilojoule OMEGA

222 at C221, with a stoichiometry of 2 atoms of tritium/tetrameric holoenzyme.

223 occurred from 2013 to 2014, or (2) a leak of tritium that had spread widely over an impermeable layer

224 Earlier tritium tracer experiments have implicated the 5'-deoxya

225 This process accounts for the results of tritium tracer experiments, it explains the radical rear

226 ed drug molecules and high-specific-activity tritium tracers.

227 At 50% conversion to GAP, triphasic tritium transfer behavior was found.

228 The extent of intermolecular tritium transfer in the criss-cross mechanism would be p

229 n 0.03 and 0.3 mM DHAP, a constant extent of tritium transfer of 1.19 +/- 0.03% occurred.

230 The extent of tritium transfer was studied as a function of initial DH

231 s well as in biota HTO and OBT, confirm that tritium transfers from HTO to OBT result in conservation

232 deling is thus more realistic for predicting tritium transfers to biota OBT under nonsteady-state con

233 However, the overall tritium turnover between HTO and the whole-organism OBT

234 Liberating this kind of tritium typically requires temperatures above 800 degree

235 required for efficient thermal desorption of tritium ultimately depends on the metal composition, its

236 ion doses from external sources and internal tritium uptakes were derived from dosimetry records thro

237 n of Ser-180 was tritiated, was photocleaved tritium was released from the protein suggesting that cl

238 and wild-type YPK, only background levels of tritium were trapped with K240M.

239 icient is greater for the incorporation of 2-tritium (which occurs exclusively by the direct pathway)

240 The strongly bound tritium, which originates from neutron capture on trace

241 e, nascent transcripts became saturated with tritium with similar kinetics (t1/2 approximately 14 min