ライフサイエンスコーパス: trityl

1 obe in comparison to the widely used Finland trityl.

2 "FBr" gives 4-(2-bromo-1,1-difluoroethyl)-1-trityl-1H-imidazole (15).

3 ivity to produce 4-(2-bromo-1-fluoroethyl)-1-trityl-1H-imidazole (8).

4 fluorenyl (1(C)), diphenylmethyl (2(C)), and trityl (3(C)) lithium was studied computationally.

5 Tris(4-substituted)-trityls [(4-R-Ph)(3)C*] have since been used in many way

6 nhanced NMR signals (T(1e) =40+/-6 ms, 40 mM trityl, 4.0 kHz MAS, 4.3 K).

7 We demonstrate that "FBr" addition to 1-trityl-4-vinyl-1H-imidazole (7) provides a convenient ro

8 the di-triethylammonium salt of 5[prime]-O -trityl-6-N-pivaloyladenosine-2[prime]-(H -phosphonate)-3

9 These phosphoramidites contained trityl (A, G, C, and U), dimethoxytrityl (A and G), or t

10 f ethers into enol ethers in the presence of trityl acetate.

11 Whereas triplet trityl-acyl radical pairs decay by competing product-for

12 rotection of the side chain thiol group with trityl alcohol and alpha-amine function with Fmoc-OSu fu

13 th trityl chloride and triethylamine or with trityl alcohol and catalytic trifluoroacetic acid, and a

14 s 15 steps starting from D-proline-derived N-trityl aldehyde 11 and proceeds in approximately 9% over

15 spectroscopy of a series of nanocrystalline trityl-alkyl and trityl-aryl ketones capable of generati

16 nished fully protected (S)- and (R)-N-Fmoc-S-trityl-alpha-methylcysteine in overall 20% yield.

17 the same overall binding configuration as S-trityl analogues at an allosteric site formed by loop L5

18 cally improves on potency: the most potent C-trityl analogues exhibit K(i)(app) </= 10 nM and GI(50)

19 vely strong exchange interaction between the trityl and nitroxide moieties determines the magnetic fi

20 ), a lower affinity for albumin than Finland trityl, and a high aqueous solubility even at acidic pH.

21 ble to participate, such as triphenylmethyl (trityl), are easily incorporated in molecular structures

22 a series of nanocrystalline trityl-alkyl and trityl-aryl ketones capable of generating correlated tri

23 yields conjugated trityl compounds such as a trityl attached to a porphyrin, an alkinyl functionalize

24 A series of trityl-based photolabile hydroxyl protecting groups have

25 a wider application of the growing number of trityl-based reactions in organic syntheses.

26 Ketones generating trityl-benzoyl radical pairs demonstrate promising perfo

27 bonylation and intersystem crossing, triplet trityl-benzoyl radical pairs have lifetimes of up to ca.

28 tyl radical, and a strongly exchange-coupled trityl biradical.

29 observed Cotton effects and stability of the trityl carbocations.

30 ment couplings, including a Felkin-selective trityl-catalyzed Mukaiyama aldol reaction, a chelate-con

31 ion from Cp*2Zr(CH3)OCH2CH2N(i)Pr2 (13) with trityl cation generates [Cp*2Zr(OCH2CH2N(i)Pr2)](+) (14)

32 ition and heterolytic cleavage (generating a trityl cation in the process), while the same adduct onl

33 alide with subsequent 1e(-) reduction of the trityl cation, (RPh)(3)C(+).

34 nd reacts with oxidants such as ferrocenium, trityl cation, and benzoquinone.

35 ward manner starting from the perfluorinated trityl cation.

36 Building on a reagent-controlled, trityl-cation-initiated enantioselective transfer hydrog

37 f an azide anion to each of three long-lived trityl cations in an acetonitrile-water solvent mixture.

38 rimethylsilyl halides to yield perhalofluoro trityl cations, which are subsequently reduced using com

39 orporated into 12-mer oligonucleotides using trityl-chemistry by an automated synthesizer.

40 her by a new water-assisted tritylation with trityl chloride and triethylamine or with trityl alcohol

41 d C-terminal cysteine esters are anchored to trityl chloride resin and extended by standard solid-pha

42 a matter of minutes by treating resin-bound trityl chloride with triethyloxonium tetrafluoroborate f

43 This yields conjugated trityl compounds such as a trityl attached to a porphyri

44 6-diaminopurine and then converted to the N9-trityl derivative to increase solubility.

45 Various esterified trityl derivatives were synthesized and characterized, a

46 ctivity of ((Tr) L)Co ((Tr) L=5-mesityl-1,9-(trityl)dipyrrin) toward various aryl azides was examined

47 ipyrromethene ligand ((Tr)L = 5-mesityl-1,9-(trityl)dipyrrin).

48 otection of the gamma-cyano alcohol 6 as the trityl ether by a new water-assisted tritylation with tr

49 The ester-derivatized trityls exhibited higher sensitivity to O2 concentration

50 mination of four different distances (Gd(3+)-trityl, Gd(3+)-NO, trityl-NO, and Gd(3+)-Gd(3+)) within

51 the solid solution of enantiomers, where the trityl group acts as a protecting group for the stereoge

52 ry was synthesized using a polymer-supported trityl group at the 5'-position.

53 l-4-tritylphenoxyl radical, which contains a trityl group at the para position, prevents C-N coupling

54 Reductive cleavage of the N-trityl group in 34 allows access to tetracyclic aziridin

55 itrogen is supported by the finding that the trityl group in the 2-position of the pyrrolidine increa

56 of the sample, and the presence of a second trityl group in the proximity.

57 is protected as the DPC derivative, and the trityl group is removed.

58 yields are obtained by employing a temporary trityl group protection strategy.

59 on with azide, reduction, and removal of the trityl group provide beta-fluorohistamine (1) as the dih

60 negative hyperconjugative interaction of the trityl group with the lone pair of the enamine nitrogen

61 g as a rotator and two m-methoxy-substituted trityl groups acting as a stator.

62 The phenyl embraces of trityl groups allowed, to some extent, the control of mo

63 The Ph* and trityl groups are readily cleaved in one pot to give y-a

64 lar substituents, or compass needle, and two trityl groups axially connected by acetylene linkages to

65 a gyroscope wheel, while the alkyne bond and trityl groups can act as an axle and shielding framework

66 In the case of peroxide 2, the bulky trityl groups may be viewed as the external static rotor

67 planar 4:1 complexes with multiple divergent trityl groups poised to engage in embraces.

68 nkshaft rotation rather than slippage of the trityl groups was obtained from molecular mechanics calc

69 es in nonpolar solvents were modified with S-trityl groups, allowing the reversible formation of disu

70 nic strategy to make compounds with multiple trityl groups.

71 accessed using a stepwise approach from the trityl halide, (RPh)(3)CCl or (RPh)(3)CBr, by controllab

72 ile N-TBDPS hemiaminal and the more stable N-trityl hemiaminal resemble the mitomycin K substitution

73 he process involves the reaction of a ketone trityl hydrazone with tBuOCl to give a diazene which rea

74 elding Lewis acid promoted deprotection of O-trityl hydroxylamine derivatives is described.

75 While Finland trityl is generally considered inert toward many reactiv

76 of the most commonly used structure (Finland trityl) is responsible for its interaction with plasma b

77 For example, S-trityl-l-cysteine (STC) and monastrol are HsEg5 inhibito

78 We previously identified S-trityl-l-cysteine (STLC) and related analogues as select

79 We previously identified S-trityl-L-cysteine (STLC) as a potent allosteric inhibito

80 e altered by deletion of L5 or addition of S-trityl-l-cysteine (STLC), an allosteric inhibitor that b

81 s incubated with the kinesin Eg5 inhibitor S-Trityl-l-cysteine (STLC).

82 Previously, we identified S-trityl-L-cysteine as a selective inhibitor of Eg5 and de

83 While both monastrol and S-trityl-L-cysteine inhibit Eg5 motility, our data reveal

84 c rotaxane device that releases an azetidine-trityl-maleimide (ATM) fluorescent probe via a retro-[4+

85 sequences (Diels-Alder, [1,3]-H shift, [1,3]-trityl migration and Diels-Alder, [1,3]-H shift, [1,3]-t

86 ration and Diels-Alder, [1,3]-H shift, [1,3]-trityl migration, Michael reaction) leading to architect

87 een shown to undergo sterically driven N-->N trityl migrations, in disagreement with previously publi

88 ge an increase of the positive charge in the trityl moiety and of the spin density on the ArS group i

89 o)alkylamine, subsequent deprotection of the trityl moiety with TFA, and immediate treatment with aq.

90 Here, we show that the Gd(3+)-trityl-nitroxide (NO) three-spin system is a versatile t

91 etric exchange-coupled biradicals, e.g., the trityl-nitroxides (TNs), possess particular magnetic pro

92 fferent distances (Gd(3+)-trityl, Gd(3+)-NO, trityl-NO, and Gd(3+)-Gd(3+)) within the same sample.

93 for 'trityl on' and approximately 32 h for 'trityl off' methods, respectively.

94 -uridine residues is approximately 46 h for 'trityl on' and approximately 32 h for 'trityl off' metho

95 reagents for synthesizing PMOs using either trityl or Fmoc-protected chlorophosphoramidate monomers.

96 with a sterically hindered triphenylmethane (trityl) or benzyl group.

97 trathiatriarylmethyl radicals, the so-called trityl- or TAM-radicals, are stable and do survive over

98 e highest enhancements were achieved using a trityl OX063 radical combined with a gadolinium relaxati

99 dulated rapid scan to measure triarylmethyl (trityl, Ox071) oxygen-sensitive probes dissolved in aque

100 employ a recently developed multifunctional trityl paramagnetic probe and electron paramagnetic reso

101 and recently reported mono- and polymetallic trityl perfluoroarylhalometalates Ph3C+FB(C6F5)3- (9), P

102 Triphenylmethyl (trityl, Ph(3)C*) radicals have been considered the proto

103 le to acquire the entire EPR spectrum of the trityl probe and assess these microenvironmental paramet

104 radical derived from the very biocompatible trityl probe, Ox071.

105 Thus, the silyl or trityl protected aziridinomitosene reacted with Cs(2)CO(

106 he syntheses and reactivity of N-TBDPS and N-trityl protected derivatives of an aziridinomitosene cor

107 enzaldehydes or o-nitrobenzyl bromides and S-trityl-protected 1 degrees -aminothioalkanes are reporte

108 ent, via an aziridine, to give predominantly trityl-protected alpha-iodo-beta-alanines, and hence nor

109 N-Trityl-protected amino ketones can be reduced selectivel

110 les, a novel reductive amination utilizing a trityl-protected aminoimidazole was developed.

111 rated that the synthesis of lanthionine from trityl-protected beta-iodoalanines is prone to rearrange

112 Structure 25 is the N-trityl-protected derivative of the proposed intermediate

113 this reaction has been elucidated, using the trityl-protected derivative, to involve initial formatio

114 Modified Appel reactions at C6 of trityl-protected hypoxanthine and guanine derivatives fo

115 ture of diastereoisomers, and one utilized a trityl-protected iodoalanine, formed via a Mitsunobu rea

116 anaidal and suffrutine A from the respective trityl-protected omega-amino alkanoates.

117 nthesis of a fluorenylmethyloxycarbonyl- and trityl-protected, C2-deuterated histidine produces a vib

118 Removal of the N-trityl protecting group could not be achieved without az

119 PPGs evolve from the traditional acid-labile trityl protecting group with proper electron-donating su

120 nthesis was accomplished by switching to the trityl protecting group.

121 2-iminato) titanium(III) methyl complex, the trityl radical ((*)CPh(3)), the anionic MeB(C(6)F(5))(4)

122 Finland trityl radical (FTR) shows very attractive EPR spectrosc

123 ormation of dimers from radicals such as the trityl radical (Gomberg radical) has triggered a large i

124 The discovery in 1900 by Gomberg that the trityl radical (Ph(3)C(.)) exists at room temperature is

125 a few exceptions do exist, for example, the trityl radical (Ph(3)C.) (ref. (1)) and carbocation (Ph(

126 H. transfer from (C(5)Ph(5))Cr(CO)(3)H to a trityl radical (tris( p- tert-butylphenyl)methyl radical

127 a-scission step that released the persistent trityl radical and a 3-nitrosoindolin-2-one derivative.

128 re instead the formation of a mixture of the trityl radical and Gomberg's dimer is favored.

129 MTriPols, in which a nitroxide (TEMPO) and a trityl radical are chemically tethered.

130 efore, we present HOPE71, a monophosphonated trityl radical derived from the very biocompatible trity

131 re we report a molecular diradical where two trityl radical groups are coupled via a meta-linked fluo

132 63-OH: a structurally modified, pH-sensitive trityl radical in which one carboxyl group is replaced b

133 We recently observed that the trityl radical OX063 undergoes consecutive oxidation to

134 [Cu(II)]-C=CAr also captures the trityl radical Ph(3)C. to give Ph(3)C-C=CAr.

135 n that the recently synthesized phosphonated trityl radical possesses long relaxation times that are

136 This newly synthesized highly hydrophilic trityl radical shows an ultranarrow linewidth (DeltaB(pp

137 ble to transfer its hydroxyl ligand onto the trityl radical to form the hydroxylated product, represe

138 ubstitution on the aromatic ring affects the trityl radical's stability (tricarboxylate salt 1-CO(2)(

139 ed to a porphyrin, an alkinyl functionalized trityl radical, and a strongly exchange-coupled trityl b

140 udying direct DNP of (13)C using SA-BDPA and trityl radical, and achieve (13)C enhancements above 600

141 s of a deuterated derivative of phosphonated trityl radical, pTAM.

142 spectroscopy paired with a monophosphonated trityl radical, pTAM/HOPE.

143 onential build-up constant of 13.8 min using trityl radical.

144 reduction of the dyads to the corresponding trityl radical.

145 ve lack of steric congestion compared to the trityl radical.

146 to TEMPO and H. transfer from TEMPO-H to the trityl radical.

147 1) s(-1), leading to a trisulfonated Finland trityl radical.

148 theses of the tetraoxygenated triarylmethyl (trityl) radical 14 and the tetrathiatriarylmethyl (trity

149 amagnetic resonance (EPR) spectroscopy and a trityl-radical-based probe (MTST).

150 ntermediate (presumably a cobalt hydride) by trityl radicals (Ar(3)C*) or by TEMPO.

151 The EPR spectroscopic properties of the trityl radicals 1 and 2 in ethanol were determined in X

152 This gave the two FTR-type trityl radicals 1 and 2 which carry a combination of the

153 In this way, we prepare three perhalofluoro trityl radicals and analyze the impact of the fluorine l

154 synthetic routes toward tris(4-substituted)-trityl radicals are not reproducible and often lead to i

155 To enhance the capability of trityl radicals as oxygen sensors, encapsulation into oi

156 monstrates that cellular permeability of the trityl radicals can be achieved by varying the type and

157 ) C-molecules hyperpolarized with persistent trityl radicals have been injected in humans.

158 se syntheses afford consistently crystalline trityl radicals of high purity for further studies.

159 Therefore, ester-derivatized trityl radicals show great potential as intracellular EP

160 ried out to assess the susceptibility of the trityl radicals to oxidation and reduction.

161 ate comparable nuclear polarization (17%) to trityl radicals used clinically (19%) through a previous

162 ation challenges-we took a route to FTR-type trityl radicals with scaffold assembly by addition of an

163 -concept study, we show that polyfluorinated trityl radicals with the, to this date, highest fluorina

164 udy extends the present scope of luminescent trityl radicals, as the functionalization of the perfluo

165 mparison to literature-known polychlorinated trityl radicals, the new polyfluorinated derivatives exh

166 ess to various monofunctionalized sulfonated trityl radicals.

167 d aid in the future design of more biostable trityl radicals.

168 ath toward a vast variety of polyfluorinated trityl radicals.

169 ne and both 2,4,6-tri-tert-butylphenoxyl and trityl radicals.

170 ) radical 14 and the tetrathiatriarylmethyl (trityl) radicals 15 and 16.

171 Triphenylmethyl (trityl) radicals have shown potential for use in organic

172 addition to various TAM-type triarylmethyl (trityl) radicals were theoretically investigated.

173 atriarylmethyl and tetrachlorotriarylmethyl (trityl) radicals.

174 xyethyl GlcN derivative was immobilized on a trityl resin support and subjected to regioselective dep

175 anilines onto a polystyrene triphenylmethyl (trityl) resin.

176 A novel cysteine derivative, N(alpha)-trityl-S-(9H-xanthen-9-yl)-l-cysteine [Trt-Cys(Xan)-OH]

177 chemistry effected by NO(g) with the use of trityl-S-nitrosothiol (Ph3CSNO) as the nitric oxide sour

178 hase peptide synthetic methodology that uses trityl side-chain anchoring for the preparation of pepti

179 nd methoxy electron-donating groups within a trityl skeleton affects the amplitude of observed Cotton

180 The trityl skeleton is functionalized with trimethylsilyl ha

181 ic applications, but the design of practical trityl structures has been limited to donor/radical char

182 Among all of the ester-derivatized trityls studied, facile hydrolysis of the acetoxymethoxy

183 Trityl-substituted alkynylpyridines 3-5 react with Pd(II

184 The trityl-substituted bisoxazoline ((TrH)BOX) was prepared

185 Carbazole and trityl substrates with two groups show saturating, incom

186 he use of the cocatalyst triphenylcarbenium (trityl) tetra(pentafluorophenyl)borate totally inhibits

187 2NiCl2, has been developed for tropylium and trityl tetrafluoroborate salts.

188 ived species by reacting trimethylsilane and trityl tetrakis(pentafluorophenyl)borate (Ph(3)C(+) TPFP

189 sitivity to O2 concentration compared to the trityl tricarboxylate CT-03.

190 behavior of two series of novel substrates: trityl (triphenylmethyl) and carbazole derivatives.

191 thiol (StBu), thiol-trimethoxyphenyl (STmp), trityl (Trt), 4-methoxytrityl (Mmt), S-acetamidomethyl (

192 radicals constitute a major advance over the trityl-type narrow-line polarization agents.

193 e are based on esterification of the Finland trityl, which is prone to hydrolysis.

194 tutes the three carboxyl moieties of Finland trityl with a high rate constant of 3.53 x 10(8) M(-1) s