ライフサイエンスコーパス: trypanosomatid

1 phologies found in parasitic kinetoplastids (trypanosomatids).

2 land plants and excavate protists, including trypanosomatids.

3 othione, the major low mass thiol present in trypanosomatids.

4 by gene duplication and is found only in the trypanosomatids.

5 nent of key glycoproteins and glycolipids in trypanosomatids.

6 of the role of OPBs as virulence factors in trypanosomatids.

7 nce against chemical and oxidative stress in trypanosomatids.

8 onserved among syntenic genes from different trypanosomatids.

9 rt, resulting in higher gene density than in trypanosomatids.

10 number and with protein expression level in trypanosomatids.

11 organellar C to U editing of tRNAs occurs in trypanosomatids.

12 at is different from human, but conserved in Trypanosomatids.

13 Splicing is essential for mRNA maturation in trypanosomatids.

14 efence against oxidative stress in parasitic trypanosomatids.

15 her PAB1 sequences, including those of other trypanosomatids.

16 trans splicing of polycistronic pre-mRNAs in trypanosomatids.

17 ual feature of these cysteine proteinases of trypanosomatids.

18 ll as other important metabolic processes in trypanosomatids.

19 wer range of amino donors than seen with the trypanosomatids.

20 y functional methionine-recycling pathway in trypanosomatids.

21 nization and segregation of kDNA networks in trypanosomatids.

22 on is available for monoxenous (single-host) trypanosomatids.

23 genes within polycistronic gene clusters in trypanosomatids.

24 truction of evolutionary relationships among trypanosomatids.

25 s an important regulatory epigenetic mark in trypanosomatids.

26 Ribosomes of trypanosomatids, a family of protozoan parasites causing

27 Recent work on the trypanosomatids, a group of eukaryotic parasites, exempl

28 Uniquely, the genomes of trypanosomatids, a group of kinetoplastid protozoa of si

29 Trypanosomatids, a group of kinetoplastid protozoans, po

30 e in trypanosomatids and detailed studies of trypanosomatid adenylyl cyclases (ACs) and phosphodieste

31 We previously showed that trypanosomatid AdoMetDC differs from other eukaryotic en

32 In both tetrameric trypanosomatid aldolases, the PTS2s from two different s

33 Trypanosomatids also possess at least three variant hist

34 In trypanosomatids, alterations in gene expression in respo

35 in several unicellular eukaryotes, including trypanosomatid and apicomplexan parasites, algae, and sl

36 in several unicellular eukaryotes, including trypanosomatid and apicomplexan parasites, algae, and sl

37 storage compartments described initially in trypanosomatid and apicomplexan parasites.

38 o drugs that exploit polyamine metabolism of trypanosomatid and malaria parasites, and propose priori

39 Tyr210 is present in trypanosomatid and plant iPGAMs, but not in the enzymes

40 any thiol metabolism, has been elucidated in trypanosomatids and anaerobes.

41 arch linking cAMP signalling to virulence in trypanosomatids and detailed studies of trypanosomatid a

42 genome contains both sequences homologous to trypanosomatids and sequences never seen before.

43 system for studying the interactions between trypanosomatids and their hosts.

44 uctase (NTR) located in the mitochondrion of trypanosomatids and, at the same time, act as inhibitors

45 the closest known non-parasitic relative of trypanosomatids, and a second bodonid, Trypanoplasma bor

46 ion of either process leads to cell death in trypanosomatids, and genetic ablation of NMT compromises

47 tively with PTS1 motif binding or release in trypanosomatids, and would therefore disrupt glycosome b

48 operating in other eukaryotes, although the trypanosomatids appear capable of chromatin remodeling.

49 Gene expression in trypanosomatids appears to be regulated largely at the p

50 Trypanosomatids are causative agents of several devastat

51 ic analysis finds that Drosophila-associated trypanosomatids are closely related to taxa that are res

52 Several species of trypanosomatids are commonly found in phytophagous insec

53 Trypanosomatids are flagellated protists that diverged e

54 Certain pathogenic trypanosomatids are highly dependent on glycolysis for A

55 The trypanosomatids are highly divergent organisms and posse

56 nt, suggesting that signalling mechanisms in trypanosomatids are highly unusual.

57 Trypanosomatids are important parasites and include the

58 Although trypanosomatids are known to rapidly transaminate exogen

59 Trypanosomatids are one of the earliest diverging eukary

60 Trypanosomatids are parasitic protozoa with a significan

61 Parasitic trypanosomatids are particularly good models for studies

62 Trypanosomatids are pathogenic protozoa that undergo a u

63 Trypanosomatids are protozoan parasites that infect thou

64 Interestingly, trypanosomatids are the only single-celled eukaryotes kn

65 g-specific spliced leader RNA, suggests that trypanosomatids assemble a highly divergent set of these

66 The unicellular trypanosomatids belong to the phylum Euglenozoa and all

67 these appear to represent a small segment of trypanosomatid biodiversity, which still remains to be u

68 ped a method that takes advantage of unusual trypanosomatid biology and skews in nucleotide compositi

69 R), a flavoprotein oxidoreductase present in trypanosomatids but absent in human cells, is regarded a

70 terminal residues are fully conserved in the trypanosomatids but are absent from other eukaryotic hom

71 acterised recently as a flagellum protein in trypanosomatids, but associated with the conoid in apico

72 ee distinct enzyme families: (1) dUTPases in trypanosomatides, C.jejuni and several other Gram-negati

73 Parasitic trypanosomatids cause important diseases.

74 Trypanosomatid cells possess an extremely precise organi

75 tion is a target for the development of anti-trypanosomatid chemotherapeutics.

76 the emergence of viruses within an important trypanosomatid clade relevant to human disease.

77 WI-tryp in T. cruzi and other members of the trypanosomatid clade.

78 The trypanosomatid coiled-coil NUP-1 protein is a lamina com

79 DNA (kDNA), the form of mitochondrial DNA in trypanosomatids, consists of thousands of interlocked ci

80 toplast DNA (kDNA), the mitochondrial DNA of trypanosomatids, consists of thousands of minicircles an

81 RNA editing in Trypanosomatids creates functional mitochondrial mRNAs b

82 e mitochondrial DNA (kinetoplast DNA) of the trypanosomatid Crithidia fasciculata consists of minicir

83 e mitochondrial DNA (kinetoplast DNA) of the trypanosomatid Crithidia fasciculata has an unusual stru

84 ) encoding a mitochondrial DNA ligase in the trypanosomatid Crithidia fasciculata, and we show that a

85 The DNA polymerase beta from the trypanosomatid Crithidia fasciculata, however, was the f

86 te periodically during the cell cycle in the trypanosomatid Crithidia fasciculata.

87 primase from a mitochondrial fraction of the trypanosomatid Crithidia fasciculata.

88 des a metabolic bypass for inhibition of the trypanosomatid dihydrofolate reductase and therefore com

89 nt at its potential as a drug target against trypanosomatids, direct evidence for the cellular functi

90 litation of nitro drugs for the treatment of trypanosomatid diseases and discuss the future prospects

91 s involved in disease phenotype in all three trypanosomatid diseases, with a particular focus on rece

92 Gene gain and loss continued during trypanosomatid diversification, resulting in the asymmet

93 lation, life cycle stage differentiation and trypanosomatid division in general.

94 cell cycle regulation of the mRNA levels of trypanosomatid DNA replication genes may be mediated by

95 These data suggest that trypanosomatids do not obey the general 5-bp rule for sn

96 anosoma brucei is a rational target for anti-trypanosomatid drug design because glycolysis provides v

97 uation of the structure-based design of anti-trypanosomatid drugs, parasite-selective adenosine analo

98 out the consequences of such modification in trypanosomatids, early branching protozoa of significant

99 rp1-3) have been identified in the parasitic trypanosomatids, early branching protozoa with no previo

100 In Trypanosomatids, endocytosis and exocytosis occur exclus

101 The related trypanosomatid Endotrypanum monterogeii also produced a

102 compounds that selectively inhibit all three trypanosomatid enzymes but not the human homologue.Adeno

103 In trypanosomatids, etiological agents of devastating disea

104 re associated with an extensive diversity of trypanosomatids (Euglenozoa, Kinetoplastea).

105 In trypanosomatids, eukaryotic parasites that perform polyc

106 unction provide the principal innovations in trypanosomatid evolution.

107 es having large TR domains was unique to the trypanosomatids examined, including T. cruzi.

108 glycoprotein mRNAs are targeted by the small trypanosomatid-exclusive RBP in T. cruzi, U-rich RBP 1 (

109 view the properties of histones in parasitic trypanosomatids, from gene organization and sequence to

110 or the high affinity of these inhibitors for trypanosomatid GAPDHs.

111 ng complementation of function between these trypanosomatid genes.

112 ngle tyrosyl-tRNA synthetase (TyrRS) gene in trypanosomatid genomes codes for a protein that is twice

113 Analysis of trypanosomatid genomes showed that the core cohesin and

114 ing the shared and derived features of known trypanosomatid genomes, but it will also identify those

115 We show that gene loss has "streamlined" trypanosomatid genomes, particularly with respect to mac

116 vidence defines the parasitic innovations of trypanosomatid genomes, revealing how a free-living phag

117 d innovation contributed to the character of trypanosomatid genomes.

118 se J-associated glucosyltransferase (JGT) in trypanosomatid genomes.

119 comparative analyses of existing and future trypanosomatid genomic resources.

120 i-fibrillarin antibodies indicated that this trypanosomatid has at least 30 fibrillarin-associated sn

121 Trypanosomatids have a large number of predicted RNA-bin

122 a major role in H(2)O(2)-detoxification, but trypanosomatids have been reported to lack this activity

123 Trypanosomatids have several remarkable and unique metab

124 was typically conserved for those genes with trypanosomatid homologs, strict colinearity was rarely o

125 eculiarities of the replication machinery in trypanosomatids, including how such divergence might aff

126 ncestral features, while evolution of extant trypanosomatids, including the human parasites, is assoc

127 TR, regarded as an ideal drug target against trypanosomatid infections, is a homodimeric flavoprotein

128 s a potential target for the chemotherapy of trypanosomatid infections.

129 offering a novel path toward therapy against trypanosomatid infections.

130 rk underlines the importance of studying the trypanosomatid intracellular life cycle stages to gain a

131 As in trypanosomatids, introns were absent and %GC was elevate

132 However, our knowledge about this pathway in trypanosomatids is very limited.

133 kDNA, the mitochondrial genome of trypanosomatids, is a DNA network composed of several th

134 Trypanosomatids lack gene regulation at the level of tra

135 Leishmania and other trypanosomatids lack glutathione reductase, and therefor

136 Trypanosomatids lack Tom40, however, and use instead a p

137 To find additional trypanosomatid lamina components we identified NUP-1 int

138 I-glucoxylan) synthesized by the monogenetic trypanosomatid Leptomonas samueli has been determined.

139 to two of the three promoter elements in the trypanosomatid Leptomonas seymouri.

140 istent with the lack of heme biosynthesis in trypanosomatids, LHR1 and LABCG5, a protein involved in

141 onsible for array differentiation during the trypanosomatid life cycle, or the apparent stability and

142 y play distinct roles at some time points in trypanosomatid life cycles and collaborative or redundan

143 in the RNAi pathway during evolution of the trypanosomatid lineage.

144 nd the evolution of human parasitism in some trypanosomatid lineages.

145 The unique aspects of the biochemistry of trypanosomatids make rational drug design an attractive

146 The findings reveal how trypanosomatids may compensate for a paucity of canonica

147 emphasis on post-transcriptional controls in trypanosomatids, messenger RNA cis-regulatory untranslat

148 s great importance for the regulation of the trypanosomatids' metabolism and can, dependent on enviro

149 nscriptomic surveys, which likely arise from trypanosomatid microbiota.

150 RNA ligase-containing complex (L-complex) in trypanosomatid mitochondria interacts by means of RNA li

151 Uridine insertion/deletion RNA editing in trypanosomatid mitochondria is a posttranscriptional RNA

152 Kinetoplast DNA (kDNA), from trypanosomatid mitochondria, is a network containing sev

153 Transcripts for key trypanosomatid mitochondrial proteins undergo extensive

154 In trypanosomatids, monoxeny is ancestral to dixeny, thus i

155 Thus, trypanosomatids must use post-transcriptional control me

156 gands and to the mRNA 5' cap4 structure, the trypanosomatid N-terminally extended form of eIF4E acts

157 A deep-branching clade of trypanosomatid narnaviruses was found, notable as Leptom

158 nt network and identifying NUP-2 as a second trypanosomatid nuclear lamina component.

159 Glycosome biogenesis in trypanosomatids occurs via a process that is homologous

160 This is the first example in trypanosomatids of the production of nuclear and mitocho

161 ulence, inhibition of TOR kinase function in trypanosomatids offers an attractive target for chemothe

162 ptomonas wallacei is a gut-restricted insect trypanosomatid only retrieved from Oncopeltus fasciatus.

163 p31 and its trypanosomatid orthologues were identified, but their am

164 communities in bumble bees infected with the trypanosomatid parasite Crithidia bombi.

165 A pol beta from the trypanosomatid parasite Crithidia fasciculata, however,

166 Species of the trypanosomatid parasite genera Trypanosoma and Leishmani

167 Trypanosomatid parasite infections have a devastating im

168 ase mining revealed three TOR kinases in the trypanosomatid parasite Leishmania major, as defined by

169 e-3-phosphate dehydrogenase (GAPDH) from the trypanosomatid parasite Leishmania mexicana in a new cry

170 the folate and biopterin transporters of the trypanosomatid parasite Leishmania.

171 TR plays a central role in the trypanosomatid parasite's defense against oxidative stre

172 Genetically, the populations of the trypanosomatid parasite, Crithidia bombi, sampled in 200

173 ing was unexpected since genome databases of trypanosomatid parasites appeared to lack general class

174 ough GSH may still play a biological role in trypanosomatid parasites beyond being a building block o

175 Apicomplexan and trypanosomatid parasites cause important human diseases,

176 Kinetoplastea such as trypanosomatid parasites contain specialized peroxisomes

177 Trypanosomatid parasites infect over 21 million people w

178 Mitochondrial mRNA editing in trypanosomatid parasites involves several multiprotein a

179 Regulation of gene expression in trypanosomatid parasites is predominantly post-transcrip

180 Trypanosomatid parasites of the genus Leishmania synthes

181 Trypanosomatid parasites provide an extreme model for th

182 ease in a caspase-independent PCD pathway in trypanosomatid parasites since caspases have not been id

183 I or type II synthases to make fatty acids, trypanosomatid parasites such as Trypanosoma brucei are

184 GPI structures are particularly abundant in trypanosomatid parasites where they can be found attache

185 For the protein products of the trypanosomatid parasites' mitochondrial genomes, the tot

186 In trypanosomatid parasites, reduction of such oxidized pte

187 Like other trypanosomatid parasites, they are purine auxotrophs (i.

188 For trypanosomatid parasites, this is mediated by type I nit

189 of the globin family is still unknown in the trypanosomatid parasites, Trypanosome and Leishmania.

190 astid and among the closest relatives of the trypanosomatid parasites, which cause such human disease

191 idants, xenobiotics and methylglyoxal in the trypanosomatid parasites, which cause trypanosomiasis an

192 ation of sterol synthesis inhibitors against trypanosomatid parasites.

193 are peroxisome-like organelles essential for trypanosomatid parasites.

194 x polypeptides that are conserved only among trypanosomatid parasites.

195 protein, AIR9, conserved in land plants and trypanosomatid parasites.

196 nt on glycolysis for ATP production, such as trypanosomatid parasites.

197 mals, it is obligatory in mRNA maturation of trypanosomatid parasites.

198 ase (3'-NT/NU) is a surface enzyme unique to trypanosomatid parasites.

199 reforms longstanding theory on clonality in trypanosomatid parasites.

200 the most fascinating and unusual features of trypanosomatids, parasites that cause disease in many tr

201 research highlights a unique drug target for trypanosomatid parasitic protozoa and a new chemical too

202 The primitive trypanosomatid pathogen of humans, Leishmania donovani,

203 y LmexCht1-chitinase gene from the primitive trypanosomatid pathogen of humans, Leishmania mexicana.

204 ells are asexual diploids, as are some other trypanosomatids, pathogenic fungi, and cultured mammalia

205 uated against the three most important human trypanosomatid pathogens (Trypanosoma brucei rhodesiense

206 uated against the three most important human trypanosomatid pathogens (Trypanosoma brucei rhodesiense

207 T. brucei and other trypanosomatid pathogens require a distinct form of post

208 It is found in bacteria, plants, and trypanosomatid pathogens, where it has been identified a

209 Trans-splicing of trypanosomatid polycistronic transcripts produces polyad

210 The trypanosomatids possess a single N-myristoyltransferase

211 However, trypanosomatid primary rRNA transcripts can first be pro

212 de novo assembly will be necessary, existing trypanosomatid projects will provide some guide to annot

213 ect genomes, including Drosophila, and three trypanosomatid protists.

214 escribed in the kinetoplast-mitochondrion of trypanosomatid protists.

215 , this structure appears to be common to all trypanosomatid protozoa and defines a novel class of cap

216 Gene expression in trypanosomatid protozoa is largely regulated posttranscr

217 mRNA cap formation in trypanosomatid protozoa is mediated through trans-splici

218 e of the unique aspects of RNA processing in trypanosomatid protozoa is the presence of a cap 4 struc

219 Among trypanosomatid protozoa the mechanism of RNA interferenc

220 In the mitochondria of trypanosomatid protozoa the precursors of messenger RNAs

221 Last, these studies call attention in trypanosomatid protozoa to the key metabolic intermediat

222 e unique thiol-redox system that operates in trypanosomatid protozoa, has been proposed as a potentia

223 Kinetoplast DNA, the mitochondrial DNA of trypanosomatid protozoa, is a network containing several

224 ional mechanisms remain poorly understood in trypanosomatid protozoa.

225 he mitochondrial, kinetoplast DNA network in trypanosomatid protozoa.

226 into the human parasite Leishmania major, a trypanosomatid protozoan belonging to one of the most an

227 The genome of the trypanosomatid protozoan genus Leishmania has been shown

228 The xenotransfection of this trypanosomatid protozoan led to their expression of the

229 However, mutants of the trypanosomatid protozoan Leishmania lacking serine palmi

230 sential roles in most eukaryotes, but in the trypanosomatid protozoan Leishmania major their function

231 lex IV) from kinetoplast mitochondria of the trypanosomatid protozoan Leishmania tarentolae.

232 To survive in its sand fly vector, the trypanosomatid protozoan parasite Leishmania first attac

233 dentification of drug resistance loci in the trypanosomatid protozoan parasite Leishmania major.

234 Trypanosomatid protozoans depend upon exogenous sources

235 ent short-chain reductase found in parasitic trypanosomatid protozoans.

236 Expression of a trypanosomatid pterin reductase (PTR1) enabled rescue of

237 we show that Crithidia luciliae, a primitive trypanosomatid, purine auxotroph, up-expressed its uniqu

238 the closest known nonparasitic relatives to trypanosomatids, recently became available.

239 al agent of Chagas disease, as well as other trypanosomatids relevant to human health, are heme auxot

240 While dixenous trypanosomatids represent one of the most dangerous path

241 rminal region, which is conserved only among trypanosomatid RET1 enzymes.

242 Genome comparison between trypanosomatids reveals that these parasites have evolve

243 study, we discuss how the unique features of trypanosomatid ribosome assembly offer potential drug ta

244 To investigate the architecture of the trypanosomatid ribosomes, we determined the 2.5-A struct

245 Trypanosomatid RNA editing is a unique process and essen

246 These data indicate that trypanosomatid RNA editing is orchestrated by a variety

247 bic residues that are highly conserved among trypanosomatid RNA editing ligases which may play a role

248 Previously we showed that trypanosomatid S-adenosylmethionine decarboxylase (AdoMe

249 Instead trypanosomatid S-adenosylmethionine decarboxylase (AdoMe

250 nto the bodonid genome sequence, relative to trypanosomatid sequences.

251 nomes are available for dixenous (two hosts) trypanosomatid species of the genera Trypanosoma, Leishm

252 atty acid and sterol biosynthesis in several trypanosomatid species were investigated using 14C- and

253 . brucei life cycle and in related parasitic trypanosomatid species.

254 The latter motif is conserved in other trypanosomatid species.

255 re likely to be found in the >600 unsurveyed trypanosomatid species.

256 pATOM36 is a trypanosomatid-specific essential mitochondrial outer me

257 he CAK sub-complex; instead it contained two trypanosomatid-specific subunits, which were indispensab

258 Previously, we showed that activity of a key trypanosomatid spermidine biosynthetic enzyme, S-adenosy

259 MSP homologues have been found in all other trypanosomatids studied to date including heteroxenous m

260 Trypanosomatids, such as the sleeping sickness parasite

261 ortholog suggests that SODA is essential for trypanosomatid survival.

262 e dehydrogenases (GAPDH) from the pathogenic trypanosomatids T. brucei, Trypanosoma cruzi and Leishma

263 Here we report the identification of a trypanosomatid TFIIB-like (TFIIB(like)) protein which ha

264 dine (trypanothione), a metabolite unique to trypanosomatids that may allow the parasites to overcome

265 ncoded by other eukaryotic parasites such as trypanosomatids (the RHS proteins) and the rhizarian Pla

266 In trypanosomatids, the adaptin-mediated sorting of protein

267 Trypanosomatids, the etiologic agents of sleeping sickne

268 In the mitochondria of trypanosomatids, the majority of mRNAs undergo massive u

269 f several pyrophosphate-utilizing enzymes in trypanosomatids, the presence of these inorganic polypho

270 free-living bodonid out-group taxa and other trypanosomatids, thereby overcoming some of the issues a

271 histone modification and variant histones in trypanosomatids therefore represents evidence for a netw

272 at this mechanism may be more widely used by trypanosomatids to control enzyme activity and ultimatel

273 wing that leucine can also be metabolized in trypanosomatids to generate acetyl-CoA.

274 The first comparison of parasitic trypanosomatids to their free-living relatives reveals t

275 In all trypanosomatids, trans splicing of the spliced leader (S

276 be possible to use PTP1B inhibitors to block trypanosomatid transmission.

277 In trypanosomatids, tRNAs undergo both cytidine-to-uridine

278 This paper demonstrates its presence in the trypanosomatid Trypanosoma cruzi.

279 shown that protein prenylation occurs in the Trypanosomatids Trypanosoma brucei (T. brucei), Trypanos

280 The trypanosomatids Trypanosoma brucei, Trypanosoma cruzi, a

281 the survival, growth, and infectivity of the trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi,

282 In trypanosomatids, trypanothione replaces the more common

283 This insertion is present in all trypanosomatid TUTases.

284 The distinctive positioning of putative trypanosomatid U3 binding sites with respect to A" and A

285 Trypanosomatids, unicellular organisms responsible for s

286 Here, we show that trypanosomatids uniquely contain both a functional AdoMe

287 Trypanosomatids utilise polycistronic transcription for

288 A deep-branching trypanosomatid viral lineage showing strong affinities t

289 ed "Leishbunyaviridae" Numerous relatives of trypanosomatid viruses were found in insect metatranscri

290 bling studies probing the biological role of trypanosomatid viruses.

291 iodic expression of DNA replication genes in trypanosomatids, we have mapped splice acceptor sites in

292 This is not the case in trypanosomatids where most genes are transcribed at an e

293 Monoxenous trypanosomatids, which are usually regarded as benign dw

294 basal branch of the highly diverse parasitic trypanosomatids, which include human pathogens Trypanoso

295 ed, roughly 60% of all genes had homologs in trypanosomatids, while 28% were Bodo-specific.

296 This may provide the trypanosomatids with a manner to rapidly and efficiently

297 est that energy production can be blocked in trypanosomatids with a tight binding competitive inhibit

298 acidocalcisome is an acidic calcium store in trypanosomatids with a vacuolar-type proton-pumping pyro

299 n of the flagellar pockets between different trypanosomatids, with their life cycles and ecological n

300 piratome regulon controlled by the conserved trypanosomatid ZC3H39/40 RNA-binding proteins.