ライフサイエンスコーパス: tubule

1 mined area (glomerulus, proximal, and distal tubules).

2 l expression in the distal part of the renal tubule.

3 pts selectively expressed in native proximal tubule.

4 transporters SGLT2 and SGLT1 in the proximal tubule.

5 logy, and pharmacology of the renal proximal tubule.

6 omycin cast could be identified in a damaged tubule.

7 nscription factors expressed along the renal tubule.

8 lomerulus and are reabsorbed by the proximal tubule.

9 n of renal and nephritic stem cells into the tubule.

10 to form stable contacts to the neighboring B-tubule.

11 rter 2 (SGLT2) along the proximal convoluted tubule.

12 inear aggregates parallel to the axis of the tubule.

13 ibiting glucose reabsorption in the proximal tubule.

14 and transport processes seen in the proximal tubule.

15 t detoxification by desert locust Malpighian tubules.

16 y formation of 2,8-DHA crystals within renal tubules.

17 etergent-insoluble plasma mebrane-associated tubules.

18 and gets sorted onto highly curved membrane tubules.

19 ion occurs mainly in the proximal and distal tubules.

20 at induce membrane curvature to shape the ER tubules.

21 r events across the epithelium in stage VIII tubules.

22 higher fluid secretion rate than uninfected tubules.

23 t, shaping membranes into moderate-curvature tubules.

24 total net extrusion per tubule to uninfected tubules.

25 th the ability to induce constrictions of ER tubules.

26 mediated by DNM2-dependent scission of these tubules.

27 Large crystals obstructed whole tubules.

28 multiple membrane proteins in renal proximal tubules.

29 surface and extended deeply around dentinal tubules.

30 venile mice results in agametic seminiferous tubules.

31 mic nanoholes in sheets as well as clustered tubules.

32 akes place in the epithelium of seminiferous tubules.

33 ier and is endocytosed by the renal proximal tubules.

34 ements and a high proportion of longitudinal tubules.

35 PtdIns4P are detected on phagosomal membrane tubules.

36 incipal cells or stellate cells in the upper tubules.

37 atrial cells that were observed to contain t-tubules.

38 high curvature of endoplasmic reticulum (ER) tubules.

39 The injured tubules acquired a proinflammatory and profibrotic pheno

40 ugmentation of NAD(+) may protect the kidney tubule against diverse acute stressors.

41 ghly metabolically active cells of the renal tubule also pair their energetic needs to the regulation

42 Malpighian tubules, analogous to vertebrate nephrons, play a key ro

43 ) system is highly expressed in the proximal tubule and contributes to Na+ and blood pressure homeost

44 where the new nephron plumbs into the distal tubule and establishes blood filtrate drainage.

45 SGLT2 inhibitors are proximal tubule and osmotic diuretics that reduce volume retentio

46 Paired imaging of t-tubules and Ca(2+) showed that the disorganized arrangem

47 0 potently blocks EHBP1L1-mediated recycling tubules and cargo turnover.

48 failure, which is associated with loss of T-tubules and disruption of cardiac dyads.

49 veloped more and deeper resin tags in dentin tubules and formed thicker hybrid layers at the composit

50 ally, we highlight the use of the Malpighian tubules and hindgut as accessible models of human diseas

51 urge in interest, research on the Malpighian tubules and hindgut of Drosophila have uncovered importa

52 hagic flux in glomerular podocytes and renal tubules and markedly increasing their susceptibility to

53 icate shapes of biological membranes such as tubules and membrane stacks are induced by proteins.

54 -BAR domain aggregation behavior in membrane tubules and on the surface of vesicles at low surface co

55 d as the primary cell type in microdissected tubules and organoids.

56 These proteins stabilized tubules and promoted their elongation, driving vacuolar

57 The collecting tubules and renal medulla are derived from Pax2-positive

58 We determine the nanoscale dimensions of ER tubules and sheets for the first time in living cells.

59 an systems acting in concert: the Malpighian tubules and the hindgut perform essential roles in excre

60 hilin) 2 enables close association between T-tubules and the junctional sarcoplasmic reticulum to ens

61 sed in each of the 14 segments of rat kidney tubules and used the proteomic data that we obtained to

62 re membrane-binding proteins associated with tubules and vesicles.

63 Of CD133(+) cells, ~85% are within injured tubules and ~15% are interstitial.

64 thick ascending limb, late distal convoluted tubule, and principal cells all adopt a gene expression

65 g cells characterized as podocytes, proximal tubules, and distal tubules in an additional 10 days.

66 nce of reticular pseudodrusen, outer-retinal tubules, and hyporeflective wedge-shaped bands.

67 ory tract, the gastrointestinal tract, renal tubules, and liver sinusoids, and their application to m

68 he baleen plate (hollow medulla, mineralized tubules, and sandwich-tubular structure) are created, an

69 docytes, proximal tubules, distal convoluted tubules, and the apical membrane of collecting duct A-ty

70 tive cells of the S3 segment of the proximal tubule, aquaporin 1-negative cells of the thin descendin

71 tubulate membranes, and in its absence WDR44 tubules are not observed.

72 tuft, glomerulus including Bowman's capsule, tubules, arteries, arterial lumina, and veins.

73 reased mtDNA levels were visualized in renal tubules as a function of aging, which was prevented by c

74 associated with enhanced autophagy in renal tubules, as assessed by measuring microtubule-associated

75 non-tubular forms in infected cells, but how tubules assemble and how protein synthesis is regulated

76 mation of stable PI4KII-containing endosomal tubules associated with this process.

77 antigens were only detected in seminiferous tubules at 14 DPI.

78 tenin were able to form presumptive proximal tubules but that they failed to further develop into dif

79 Tubules can become infected with a protozoan, Malpighamo

80 The renal (Malpighian) tubules can secrete fluid faster on a per-cell basis tha

81 veals that the high membrane curvature of ER tubules catalyzes the nucleation of a neutral lipid lens

82 results demonstrate a primary renal proximal tubule cell AT(2)R natriuretic defect in SHR that may co

83 Fourteen different proximal tubule cell lines, representing six species, were grown

84 angial cells, and identification of proximal tubule cell populations defined by pathogenic expression

85 Moreover, the finding that proximal tubule cell-specific amphiregulin knockout mice were pro

86 mphiregulin into knockout mice with proximal tubule cell-specific deletion of amphiregulin's releasin

87 l ureteral obstruction in mice with proximal tubule cell-specific knockout of amphiregulin.

88 itor cells (Six2 (Cre) Dnmt3a/3b) and kidney tubule cells (Ksp (Cre) Dnmt3a/3b).

89 increased oxidative stress in renal proximal tubule cells (RPTCs).

90 y reconstruct the spatial position of kidney tubule cells and to predict corticomedullary gene expres

91 1beta processing) in isolated renal proximal tubule cells from WT mice whereas these increases were a

92 Here, we report that proximal tubule cells in kidneys sense elevated endogenous, gut m

93 talk is further studied by exposing proximal tubule cells to hyperglycemic conditions and monitoring

94 m(4-6) and pH homeostasis by kidney proximal tubule cells(7,8).

95 to apical plasma membranes of renal proximal tubule cells, internalization/inactivation of NHE-3 (sod

96 d on whole-kidney samples and isolated renal tubule cells.

97 matched the transcriptome of native proximal tubule cells.

98 o binding of CL-11 on hypoxia-stressed renal tubule cells.

99 mmatory cytokines in cultured human proximal tubule cells.

100 This tubule-centred model of diabetic kidney physiology predi

101 knockout mice (DE(AC) ), and Edn1 connecting tubule/collecting duct-specific conditional knockout mic

102 r groups of mice: wild-type mice, connecting tubule/collecting duct-specific Dot1l conditional knocko

103 which encodes endothelin 1 in the connecting tubule/collecting duct.

104 al stem cells (RSCs) in the ureter and lower tubules comprise a unique, unipotent regenerative compar

105 nnected to host vasculature, alongside renal tubules comprising tubular epithelia of different nephro

106 In PVD soma and dendrite branch points, ER tubules connect to form networks.

107 Furthermore, we show that the ER tubule constrictions also occur in cells expressing TGB2

108 for the maintenance of the Drosophila renal tubule could provide new insights into the molecular pat

109 ney dysfunction, and (d) attenuated proximal tubule damage.

110 asolateral membrane of the distal convoluted tubule (DCT) and plays an important role in the regulati

111 e T303 is localized in the distal convoluted tubule (DCT) but not in the thick ascending limb (TAL) o

112 nsporter NCC in the kidney distal convoluted tubule (DCT) regulates urinary NaCl excretion and BP.

113 l potassium channel in the distal convoluted tubule (DCT), comprising the inwardly rectifying potassi

114 recursors into early stage distal convoluted tubules (DCTs) during nephrogenesis.

115 gral ER protein, induces constrictions of ER tubules, decreases the mobility of ER luminal content, a

116 AKI induced proximal tubule dedifferentiation, with a pronounced nephrogenic

117 d distribution at the lateral membrane and T-tubules, depending on site-specific interacting proteins

118 kd1-knockout and normal mice and in proximal tubule-derived, cultured pkd1-knockout cells.

119 gthening apical surface during single-celled tubule development.

120 signaling plays a critical role in proximal tubule development.

121 ons vary between cellular systems, including tubule diameter and the presence of microtubules.

122 alate (CaOx) crystal deposition led to rapid tubule dilation, activation of PKD-associated signaling

123 ephron polycystin-1 in the absence of cysts, tubule dilation, or enhanced cell proliferation.

124 nockout mice showed no apparent renal cysts, tubule dilation, or increased cell proliferation.

125 recruitment, associated with transverse (t)-tubule disruption.

126 edominantly presented in podocytes, proximal tubules, distal convoluted tubules, and the apical membr

127 uring the cellular transcriptome of proximal tubule during repair.

128 ized by cystine accumulation, renal proximal tubule dysfunction, and kidney failure.

129 ofile gene expression in each type of kidney tubule epithelial cell.

130 d chromatin accessibility in kidney proximal tubule epithelial cells (PTECs) derived from subjects wi

131 P (yes-associated protein) in renal proximal tubule epithelial cells (RPTC) in patients with diabetes

132 that operates specifically in renal proximal tubule epithelial cells (RPTEC).

133 gation and puncture (CLP) and human proximal tubule epithelial cells (TEC; HK2) were exposed to infla

134 t the basolateral membrane of renal proximal tubule epithelial cells, mediates the renal excretion of

135 sociated ligand exposed by ischemia on renal tubule epithelial cells, which after recognition by coll

136 Tubule epithelial regeneration leads to the resolution o

137 TNFR2(+) CD133(+) cells in tubules express proliferation marker phospho-histone H3(

138 e an online information resource, the Kidney Tubule Expression Atlas.

139 eins at the nuclear envelope and sites of ER tubule fission.

140 Protein abundance along the renal tubule for many commonly studied water and solute transp

141 ivity commonly occurs due to opened dentinal tubules for many reasons.

142 itochondrial density, networks of transverse tubules), force-frequency and force-length relationships

143 ocations in which ~50 um-diameter epithelial tubules form by cell coalescence and structural maturati

144 Epithelial tubules form critical structures in lung, kidney, and va

145 disruption decreases viral mRNA translation, tubule formation and virus replication, confirming a fun

146 ated decreased proliferation, migration, and tubule formation, and Cept1Lp/LpCre (+) mice had reduced

147 ory cytokine secretion, abolishes phagosomal tubule formation, and impairs major histocompatibility c

148 kidney development is sufficient to disrupt tubule formation, and significantly increases Akap12 exp

149 ER tubules formed by Drp1 promote mitochondrial division by

150 ay infect the epithelium of the seminiferous tubule, formed by Sertoli cells, thus leading to impaire

151 ll therapy of vessel-forming cells and renal tubule-forming cells aimed at alleviating renal hypoxia

152 Notably, after renal injury, renal tubule-forming cells and vessel-forming cells infused in

153 We administered renal tubule-forming cells derived from human adult and fetal

154 tly injecting vessel-forming cells and renal tubule-forming cells into the subcutaneous and subrenal

155 h mesenchymal-epithelial transition in renal tubule-forming cells, indicating paracrine effects.

156 augmented in vivo tubulogenesis by the renal tubule-forming cells.

157 sed misdirection of cargo-carrying transport tubules from endosomes, resulting in immature WPBs that

158 We manually dissected kidney tubules from rat kidneys and subjected samples to protei

159 show that PACSIN1 and EHD1 assemble membrane tubules from the developing intracellular cilium that at

160 RP3 inflammasome induction in renal proximal tubules from WT mice.

161 scriptomes to gene sets for various proximal tubule functions (sodium and water transport, protein tr

162 ions of the ER, the sites where different ER tubules fuse.

163 proliferation in the elongating nephron; and tubule fusion where the new nephron plumbs into the dist

164 We identified >17,000 genes in each proximal tubule group, including 145 G-protein-coupled receptors.

165 In the kidney, proximal and distal tubules had markedly higher mtDNA levels compared with c

166 The Drosophila tubule has 2 main secretory cell types: active cation-tr

167 The proximal tubule has a remarkable capacity for repair after acute

168 out" crystals by purposefully dilating renal tubules has not previously been recognized.

169 Infected tubules have a greater surface area and a higher fluid s

170 Adult Drosophila Malpighian tubules have low rates of cell turnover but are vulnerab

171 face area and fluid secretion rate, infected tubules have similar total net extrusion per tubule to u

172 d as podocytes, proximal tubules, and distal tubules in an additional 10 days.

173 membrane, the lateral membrane groove, and T-tubules in cardiomyocytes from wild-type (N=3), dystroph

174 r structural parallels; disorganization of t-tubules in failing cells was strikingly reminiscent of t

175 observed to interact transiently on membrane tubules in hepatoma cells and along LD-centric autophagi

176 molecular switch for the loss of transverse tubules in HF and their restoration following tadalafil

177 port that Drp1 directly shapes peripheral ER tubules in human and mouse cells.

178 motypic fusion of endoplasmic reticulum (ER) tubules in the formation of the interconnected ER networ

179 3 in mature VWF at Golgi pH form helical VWF tubules in Weibel Palade bodies and template dimerizatio

180 Nephron tubules in zebrafish are composed of segment populations

181 layed key functional aspects of the proximal tubule, including protein endocytosis and increased gamm

182 n of MASP-2 and C3 in both the glomeruli and tubules indicated that the lectin pathway likely contrib

183 ssion of the fly FGF branchless (bnl) in the tubules induces expression of MFS2 and increases Malpigh

184 Proximal tubule injury can initiate CKD, with progression rates t

185 ury at these sites and new sites of proximal tubule injury.

186 g cells is not limited to uniform sheets and tubules; instead, we suggest the ER contains a continuum

187 se synchrony, increased CaT) and preserved t-tubule integrity.

188 ochondria contact sites, where peripheral ER tubules interact with mitochondria.

189 nd deposition of C3 and C5b-9 that can cause tubule-interstitial damage, further worsening disease pr

190 The Malpighian tubule is a particularly excellent model to study rapid

191 r of studies suggest that the renal proximal tubule is a site of injury in diabetic nephropathy (DN),

192 secretion of organic solutes by the proximal tubules is an essential intrinsic kidney function.

193 Since the diameter of the mitochondrial tubules is generally close to the diffraction limit of l

194 ible for LTCCs recruitment to and from the T-tubules is not well known.

195 CCs and contributes to LTCC recruitment to T-tubules is unknown.

196 hese increases were absent in renal proximal tubules isolated from P2X4 KO mice.

197 remaining podocytes, activation of proximal tubule-like parietal epithelial cells identified by ultr

198 tly replaced by bone tissue and seminiferous tubule-like structures.

199 Increased fluid secretion rate of infected tubules likely exposes locusts to greater water stress a

200 crotubule (MT), many are at the junctions of tubules likely to reinforce the triplet.

201 nearly 150 differentially expressed proximal tubule lncRNAs during fibrosis suggests they may have un

202 SerpinB2 influences tubule-macrophage crosstalk by supporting tubular CCL2 e

203 eld within a large number of parallel hollow tubules made of a mixed ionic-electronic conductor (MIEC

204 ls confirmed low expression of many proximal tubule marker proteins.

205 ered substantially in expression of proximal tubule markers.

206 l cytomorphology, and expression of proximal tubule markers.

207 sodium retention and its location in kidney tubules may vary with time in nephrotic syndrome (NS).

208 addition, the resins' infiltration to dentin tubules, mechanical performance, and chemical properties

209 al transmembrane domain (TMD) and bind the T-tubule membrane through their cytosolic N-terminal regio

210 y revealed densely packed, rapidly moving ER tubules mistaken for sheets by conventional light micros

211 re, we have created 3D vascularized proximal tubule models composed of adjacent conduits that are lin

212 At the lateral membrane and T-tubules, Na(v)1.5 localization and function remain insuf

213 kinase domain-like (MLKL) protein-dependent tubule necroptosis.

214 f disorganization and loss of the transverse tubule network.

215 ere differentially expressed in the proximal tubule of males versus females.

216 , while smaller spines contain just a single tubule of smooth ER.

217 he interaction between cells in the proximal tubule of the kidney, free light chains, renal fibroblas

218 zed regions of curvature into high-curvature tubules of extended lengths.

219 of cells from the proximal and non-proximal tubules of healthy and fibrotic human kidneys to map the

220 nal beta(3)-ARs are mostly confined to the T-tubules of healthy rat cardiomyocytes.

221 suggests that CD133(+) cells in regenerating tubules of kidneys undergoing ACR represent proliferatin

222 at the groove of DeltaSIV and increased in T-tubules of mdx cardiomyocytes.

223 he round spermatid stage in the seminiferous tubules of the testis in ZFP628-deficient mice that resu

224 , and epithelial proliferation in developing tubules or cysts, the severity of cystogenesis upon Tulp

225 used RNA sequencing in microdissected kidney tubules or single cells isolated from the kidney to prof

226 phage cell line with hypoxia-treated primary tubules overexpressing periostin, or treating such macro

227 ining RT-PCR, immunohistochemistry, isolated tubule perfusion, in vitro cell studies, and in vivo stu

228 e required for the differentiation of distal tubule precursors into early stage distal convoluted tub

229 se factors colocalized with tfap2a in distal tubule precursors.

230 t reduced levels of GATAe gene expression in tubule principal cells induce uncontrolled cell prolifer

231 nf4a) is a major regulator of renal proximal tubule (PT) development.

232 Symptoms of LS include proximal tubule (PT) dysfunction typically characterized by low m

233 d glomerular filtration or impaired proximal tubule (PT) reabsorption, or both.

234 f protein reabsorption in the human proximal tubule (PT) using Michaelis-Menten kinetics and molar ur

235 rption of transferrin (Tf) in renal proximal tubules (PTs).

236 , delivery of protein nanocages to the renal tubules remains a major challenge because of the glomeru

237 n the joining region (mut(PG1)JPH2) caused T-tubule remodeling and dyad loss, showing that an interac

238 Single-celled tubules represent a complicated structure that forms dur

239 d pressure (BP) that was normalized by renal tubule-restricted rescue with D(1) R-wild-type but not t

240 1.2 channel abundance along cardiomyocyte T-tubules, resulting in the appearance of channel 'super-c

241 rehensive transcriptomic map of the proximal tubule revealed sexually dimorphic gene expression that

242 rom humans and mice and for a microdissected tubule RNA-seq dataset from rat.

243 ipitation of ETBR and GRK4 in renal proximal tubule (RPT) cells from both WKY and SHRs but was greate

244 Renal proximal tubule (RPT) cells from hypertensive (HT) Euro-American

245 2100 Da PEG molecule (ICG-PEG45) as a renal-tubule-secreted near-infrared-emitting fluorophore for h

246 iated signaling pathways, and hypertrophy in tubule segments along the affected nephrons.

247 eins expressed in each of 14 different renal tubule segments from rat.

248 Light microscopy of proximal tubules showed geographic isometric vacuolization, corre

249 lthough inactivating Stat3 in Pkd1-deficient tubules slightly reduced cyst burden, it resulted in a m

250 e at two opposing sides of the mitochondrial tubules so that they form extended opposing distribution

251 medullary blood flow and decreases in distal tubule sodium reabsorption that offset acute rises in BP

252 sorption was not downregulated, and proximal tubule sodium reabsorption, measured by lithium clearanc

253 We moreover assessed T-tubules sodium current by recording whole-cell sodium cu

254 A T-tubules sodium current could, however, not be demonstrat

255 nflammation and fibrosis, collected proximal tubule-specific and bulk cortex mRNA at day 5 or 10, and

256 subunit or alpha-subunit silencing or kidney tubule-specific beta-ENaC or alpha-ENaC knockout mice di

257 dules, and previously unappreciated proximal tubule-specific bidirectional lncRNA regulation.

258 Conditional kidney tubule-specific ENaC gamma-subunit knockout mice display

259 We generated mice with proximal tubule-specific expression of an L10a ribosomal subunit

260 Tubule-specific Hnrnpf knockout (KO) mice were generated

261 We also used conditional kidney tubule-specific knockout mice lacking ENaC subunits to a

262 Tubule-specific knockout of Shh in mice inhibited fibrob

263 We used mice with conditional tubule-specific overexpression of periostin or knockout

264 A proximal tubule-specific TFEB-knockout mouse exhibited progressio

265 In current study, we found that a proximal tubules-specific DsbA-L knockout mouse (PT-DsbA-L-KO) at

266 ction between LTCC and JPH2 is crucial for T-tubule stabilization.

267 ed fly life span, suggesting that Malpighian tubule stones are a key element whereby high Pi diet red

268 expression of MFS2 and increases Malpighian tubule stones suggesting that bnl is the endogenous phos

269 further develop into differentiated proximal tubules, suggesting that beta-catenin signaling plays a

270 because of the absence of a well-developed t-tubule system in most of these cells.

271 d tubular systems in vitro, reminiscent of t-tubule system in muscle cells.

272 tion of filtered phosphate in proximal renal tubules, thereby critically contributing to phosphate ho

273 ibiting glucose reabsorption in the proximal tubule, these agents promote glycosuria, thereby reducin

274 ticle that can be targeted to renal proximal tubules through glomerular filtration.

275 effectively effluxed out of normal proximal tubules through P-glycoprotein transporter while being r

276 SER in spines shifted from a single tubule to complex spine apparatus after LTP.

277 relies on abundant mitochondria in the renal tubule to generate sufficient ATP to provide the energy

278 ccurs in response to signals passed from the tubule to the glomerulus: high levels of glucose in the

279 tubules have similar total net extrusion per tubule to uninfected tubules.

280 nditions, LTCCs are redistributed from the T-tubules to disrupt CICR.

281 tention shifted from the proximal and distal tubules to the collecting system.

282 translocates from the center of seminiferous tubules to the spermatogonial stem cell (SSC) 'niche' in

283 aARM, moves together with RHD3 to pull an ER tubule toward another and stays with the newly formed 3-

284 ism by which "multispecific" kidney proximal tubule transporters exert distinct physiological effects

285 d membrane invaginations known as transverse tubules (TT).

286 stals-can grow out of and retract inside the tubules via mainly diffusional Coble creep along the MIE

287 In the kidney, proximal tubule was enriched in humans (P=8.5E-5 for eGFR; P=7.8E

288 Inside of lipid bilayer tubules, we find linear aggregates parallel to the axis

289 ifferentiate into mature proximal and distal tubules, whereas expression of the related Pax8 protein

290 zes as distinct clusters in the groove and T-tubules which density, distribution, and organization pa

291 ption is augmented by growth of the proximal tubule, which (alongside sodium-glucose cotransport) fur

292 ry dentin through shallowly exposed dentinal tubules, which decreases dentin permeability.

293 s at the inner junction between the A- and B-tubules, which indicates the inner junction protein is a

294 eased in split-open isolated collecting duct tubules, while ENaC protein levels remained unchanged.

295 Because excessive fusion of ER tubules will lead to the formation of sheet-like ER, the

296 units called nephrons, which are epithelial tubules with a sequence of segments each expressing a di

297 c vacuolization, corresponding to a focus of tubules with abundant intracellular viral arrays.

298 ovascular units" comprising both vessels and tubules with potential interaction.

299 procal interaction were upstream of proximal tubule YAP activation in diabetic kidneys.

300 This study demonstrates that proximal tubule YAP-dependent paracrine mechanisms play an import