ライフサイエンスコーパス: tufted cell

1 e principal neurons of the bulb, mitral, and tufted cells.

2 volving another glutamatergic cell type, the tufted cells.

3 Ng in maturation and dendritic remodeling of tufted cells.

4 weaker in mitral cells and less modulated in tufted cells.

5 ory inputs targeted onto excitatory external tufted cells.

6 s asynchronous glutamate release from mitral/tufted cells.

7 ation mainly reflects the activity of mitral/tufted cells.

8 with a feature-detecting function for mitral-tufted cells.

9 was not detected in the glutamatergic mitral/tufted cells.

10 , a small number of which are LOT-projecting tufted cells.

11 reduced dendrodendritic inhibition in mitral/tufted cells.

12 cortex but not in olfactory bulb mitral and tufted cells.

13 ctive output onto interneurons and principal tufted cells.

14 nsient response profile, typical of external tufted cells.

15 asts with the transient response in external tufted cells.

16 rons are similar between mitral and external tufted cells.

17 through feedforward excitation from external tufted cells.

18 ity of mitral cells but had little impact on tufted cells.

19 asing the spike output of presumptive mitral/tufted cells.

20 and intrinsic properties between mitral and tufted cells.

21 in 36-mediated gap junctions on MCs, but not tufted cells.

22 hemical features of superficial and external tufted cells.

23 s), sparing the other principal neurons, the tufted cells.

24 nearly eliminated spiking in mitral, but not tufted, cells.

25 results suggest that disinhibition of mitral/tufted cells accounts for the observed enhancement in c-

26 ibuted to the differences between mitral and tufted cell activity.

27 pendent transcription factor NPAS4 in mitral/tufted cells affects bulbar and cortical odour represent

28 om the dendritic tufts of other ET or mitral/tufted cells affiliated with the same glomerulus.

29 Surprisingly, mitral and tufted cells also showed firing mode differences.

30 7) was equivalent across mitral and external tufted cells and could be explained by a single pool of

31 Single-unit recordings from mitral/tufted cells and local field-potential recordings from b

32 ic and dendrodendritic circuitry in external tufted cells and mitral cells, respectively, tunes the p

33 es from their downstream synaptic partners - tufted cells and mitral cells.

34 l dendrites, whereas the dendrites of mitral/tufted cells and periglomerular interneurons form dendro

35 ct functional loops involving the mitral and tufted cells and their cortical targets.

36 to the canonical mitral-to-piriform pathway, tufted cells and their target regions are ideally positi

37 machinery that shapes connectivity of mitral/tufted cells and thereby discriminative bulbar odour rep

38 served to be differential between mitral and tufted cells and was odor invariant but strongly modulat

39 uts mediated by mitral, tufted, and external tufted cells, and, in turn, they indiscriminately releas

40 or neuron nerve terminals (input) and mitral/tufted cell apical dendrites (output).

41 stricted to the soma and proximal portion of tufted cell apical dendrites.

42 ncy responses in mitral cells, compared with tufted cells, are due to weaker excitation and stronger

43 lfactory bulb primary output neurons, mitral/tufted cells, are glutamatergic and excite inhibitory in

44 modulation adds an excitatory bias to mitral/tufted cells as opposed to increasing response gain or s

45 pendent on AMPA and NMDA receptors in mitral/tufted cells as well as on a previously undescribed meta

46 cell mediated feedback inhibition of mitral/tufted cells, as measured with field potential recording

47 ion of the raphe nuclei led to excitation of tufted cells at rest and potentiation of their odor resp

48 re first innervated by centrifugal or mitral/tufted cell axon collaterals in the GCL and that these i

49 ns in naive animals leads to an expansion of tufted cell axons that is identical to the changes cause

50 influence relatively large groups of MCs and tufted cells belonging to clusters of at least 15 glomer

51 (comprising the dendrites of both mitral and tufted cells) between E17 and E18.

52 Cs of the nerve layer, as well as mitral and tufted cells, but was excluded from GABAergic interneuro

53 ncreases the number of associated mitral and tufted cells by 40% and 100%, respectively.

54 ic excitability and more irregular firing in tufted cells can combine to drive distinct responses of

55 We suggest that sister mitral/tufted cells carry two different channels of information

56 xons produced a fast disinhibition of mitral/tufted cells consistent with a rapid and synchronous rel

57 By contrast, MOB external tufted cells contained two alpha subunit types (alpha1 a

58 sponse profiles in mitral cells and external tufted cells could be attributed to slow dendrodendritic

59 This stronger response of tufted cells could be partially attributed to synaptic d

60 tial to odor concentration fluctuations with tufted cells coupling more strongly for the 20 Hz stimul

61 lar stuttering of action potential clusters, tufted cells demonstrated a greater propensity to stutte

62 Neither mitral/tufted cell dendrites nor olfactory bulb astrocytes beca

63 temporal separation of the effects on mitral/tufted cell dendrites vs. somata were observed.

64 , attract postsynaptic innervation by mitral/tufted cell dendrites, and endow these cells with respon

65 mature olfactory receptor cell axons, mitral/tufted cell dendrites, and glial cells as well as a syna

66 lia (RG), astrocytes, ORNs, JG cells, mitral/tufted cell dendrites, and olfactory Schwann cells throu

67 The interactions between ORN axons, mitral/tufted cell dendrites, juxtaglomerular (JG) cells, and g

68 at both olfactory nerve terminals and mitral/tufted cell dendrites.

69 spines and dendrites, but negative in mitral/tufted cell dendrites.

70 by P6W, there was an overgrowth of mitral or tufted cells dendrites and a decreased number of active

71 f glomeruli is the penetration of the mitral/tufted cell dendritic zone by olfactory receptor cell ax

72 the Na beta 1 and Na alpha II signals within tufted cells disappeared almost completely.

73 IFICANCE STATEMENT Olfactory bulb mitral and tufted cells display different odor-evoked responses and

74 in synaptic wiring selectively in mitral and tufted cells during embryonic development and performed

75 estin was experimentally induced in external tufted cells during regeneration of olfactory sensory ne

76 tions (IBPs) mediated by a class of external tufted cells (ET cells) specifically link isofunctional

77 SACs release both GABA and DA onto external tufted cells (ETCs) in other glomeruli.

78 both mitral/tufted cells (MTCs) and external tufted cells (ETCs), the two major excitatory neurons th

79 onsiveness of PG cells with that of external tufted cells (eTCs), which are a class of excitatory cel

80 forebrain, which led to a mixture of mitral/tufted cell excitation and suppression.

81 ree antagonists significantly reduced mitral/tufted cell excitation of granule cells as measured with

82 el odorants, quantitative analysis of mitral-tufted cell excitatory ORFs revealed that the median ORF

83 OB projection neurons, mitral and tufted cells exhibit both spiking and subthreshold membr

84 sion of voltage-gated potassium currents, as tufted cells exhibited faster action potential repolariz

85 odor discrimination learning, mitral but not tufted cells exhibited improved pattern separation, alth

86 Compared to mitral cells, tufted cells exhibited twofold greater excitability and

87 sistent with previous studies, we found that tufted cells fire with higher probability and rates and

88 on of spontaneous and odor-driven mitral and tufted cells' firing activity.

89 cellularly recorded IPSP amplitude in mitral/tufted cells following LOT stimulation.

90 ges induces a strong increase in Ng-positive tufted cells from P10 to P20, whereas no changes have be

91 ptic processing at the reciprocal mitral and tufted cell-granule cell microcircuit, the most abundant

92 Although external tufted cells had a 4.1-fold larger peak EPSC amplitude,

93 esynaptic afferents onto mitral and external tufted cells had similar quantal amplitude and release p

94 lfactory system second-order neurons, mitral-tufted cells, have odorant receptive fields (ORFs) (mole

95 llular recordings from identified mitral and tufted cells in anesthetized rats demonstrate that nasal

96 SCs (mIPSCs) recorded in mitral and external tufted cells in rat olfactory bulb slices.

97 h also reduced the spike precision of mitral/tufted cells in response to simulated stimuli.

98 tor, Tbx21, which is expressed by mitral and tufted cells in the mature OB.

99 nnections with centrifugal inputs and mitral/tufted cells in the mouse olfactory bulb.

100 s VPAC2R is expressed in mitral and external tufted cells in the OB.

101 (OSNs) in the periphery project onto mitral/tufted cells in the olfactory bulb (OB) and these mitral

102 ns are triggered by the activation of mitral/tufted cells in the olfactory bulb and are abolished dur

103 g pyramidal cells in the cerebral cortex and tufted cells in the olfactory bulb during development.

104 taining suggests that it receives input from tufted cells in the olfactory bulb in addition to mitral

105 ed precisely sniff-locked activity in mitral/tufted cells in the olfactory bulb of awake mouse.

106 ts that can influence the activity of mitral/tufted cells in the spatiotemporal domains.

107 ocust brain (the functional analog of mitral-tufted cells in the vertebrate olfactory bulb) to natura

108 in the olfactory bulb (OB) and these mitral/tufted cells in turn project to piriform cortex (PC).

109 r of their targets (glomeruli and mitral and tufted cells) in corresponding divisions of the MOB.

110 in relatively large cells, possibly external tufted cells, in the periglomerular region.

111 the time course of depolarization of mitral/tufted cells, indicating that K+ accumulation mainly ref

112 In individual mitral and tufted cells, inhibition was larger at specific respirat

113 ract with the apical dendrites of mitral and tufted cells inside glomeruli at the first stage of olfa

114 An OB circuit with tufted cells intermediate between OSNs and MCs suggests

115 Ng expression in developing tufted cells is also modulated at the cellular level: at

116 s modulate the OB output neurons, the mitral/tufted cells, is unknown.

117 erular lateral inhibition between mitral and tufted cells' lateral dendrites whereas diverse subtypes

118 lfactory bulb projection neurons, mitral and tufted cells (M/T), is modulated by pairs of reciprocal

119 naptic targets of OSNs, including mitral and tufted cells (M/TCs) and juxtaglomerular cells, form glo

120 renaline (NA) increases excitation of mitral/tufted cells (M/TCs) by decreasing the release of GABA f

121 Furthermore, mitral/tufted cells (M/TCs) show differential coupling of their

122 evoked responses has been reported in mitral/tufted cells (M/TCs).

123 The OB projection neurons, called mitral and tufted cells (M/Ts), have a single dendrite that branche

124 ough the action potential activity of mitral/tufted cells (M/Ts), whose selectivity and tuning to odo

125 factory bulb (OB), principal neurons (mitral/tufted cells) make reciprocal connections with local inh

126 liable, short-latency firing consistent with tufted cell-mediated excitation.

127 Compared to external tufted cells, mitral cells have a prolonged afferent-evo

128 ation of nAChRs directly excites both mitral/tufted cells (MTCs) and external tufted cells (ETCs), th

129 tuning was heterogeneous in both mitral and tufted cells (MTCs) and GCs but relatively constant with

130 ically inhibits the OB output neurons mitral/tufted cells (MTCs) by GABA release from SACs: (2) gap j

131 mouse olfactory bulb (OB), where mitral and tufted cells (MTCs) form parallel output streams of odor

132 siently inhibited the excitability of mitral/tufted cells (MTCs) that relay olfactory input to the co

133 c interactions between excitatory mitral and tufted cells (MTCs), the OB projection neurons, and a co

134 om the mouse olfactory bulb (OB), mitral and tufted cells (MTCs).

135 reaching the cortex via inhibition of mitral/tufted cells (MTs).

136 citatory neurons, mitral/tufted and external tufted cells, nor did it alter their intrinsic excitabil

137 However, mitral/tufted cell odorant receptive fields and behavioral odor

138 ly, bulbar cholinergic enhancement of mitral/tufted cell odorant responses was robust and occurred in

139 These results confirm that mitral/tufted cells of the anterior and posterior sub-regions o

140 Mitral/tufted cells of the olfactory bulb receive odorant infor

141 d the parallel pathways formed by mitral and tufted cells of the olfactory system in mice and charact

142 hypothesized that experience-induced mitral-tufted cell ORF changes reflect modulation of lateral an

143 The temporal specificity of mitral/tufted cell output provides a potentially rich source of

144 ruli and about 50% of the 160,000 mitral and tufted cells per bulb.

145 cells in the olfactory bulb (OB), mitral and tufted cells, play key roles in processing and then rela

146 hybridization identified distinct mitral and tufted cell populations with characteristic transcriptio

147 Stronger activation of mitral/tufted cells produced a low-threshold Ca2+ spike (LTS) t

148 s respiration-coupled activity in mitral and tufted cells produced by sensory synaptic inputs from na

149 Weak activation of mitral/tufted cells produced stochastic Ca2+ transients in indi

150 e, at P10, bulb and laminar sizes and mitral/tufted cell profile number had begun their decline, and

151 tive approach of retrogradely tracing mitral/tufted cell projections from different nuclei of the vom

152 In turn, mitral and tufted cells receive and relay this information to highe

153 Given that mitral-tufted cells receive exclusive excitatory input from olf

154 cells in the olfactory bulb (OB), mitral and tufted cells, receive direct sensory input and generate

155 ially attributed to synaptic differences, as tufted cells received stronger afferent-evoked excitatio

156 External tufted cells receiving input from rI7 --> M71 glomeruli

157 namic center-surround organization of mitral/tufted cell receptive fields.

158 Individual olfactory bulb mitral/tufted cells respond preferentially to groups of molecul

159 ith sustained transmission, whereas external tufted cells responded transiently.

160 n with sustained responses, whereas external tufted cells responded transiently.

161 Glomerular and mitral and tufted cell responses were sparse and locally heterogene

162 lar neurons mediates inhibition of principal tufted cells, retrograde inhibition of sensory input and

163 pulse LOT stimulation, suppression of mitral/tufted cell single-unit spontaneous activity following L

164 Cholinergic stimulation increased mitral/tufted cell spiking in the absence of inhalation-driven

165 s to access mitral cell (MC) and superficial tufted cell (sTC) subpopulations separately.

166 We find that tufted cells substantially outperform mitral cells in de

167 g the diverse functional roles of mitral and tufted cell subtypes.

168 ifferences in principal mitral cell (MC) vs. tufted cell (TC) spike-time synchrony: TCs robustly sync

169 f olfactory (OB) bulb mitral cells (MCs) and tufted cells (TCs) are known to depend on prior odor exp

170 use olfactory system, mitral cells (MCs) and tufted cells (TCs) comprise parallel pathways of olfacto

171 selectively modulate activities of CCKergic tufted cells (TCs) in the mouse olfactory bulb (OB) of e

172 f olfactory bulb (OB) mitral cells (MCs) and tufted cells (TCs) is linked to a variety of computation

173 ordings, we show that mitral cells (MCs) and tufted cells (TCs) of the male C57BL/6 mouse olfactory b

174 The output mitral cells (MCs) and tufted cells (TCs) of the mammalian olfactory bulb (OB)

175 n olfactory bulb, the mitral cells (MCs) and tufted cells (TCs), differ markedly in physiological res

176 response patterns over time as compared with tufted cells (TCs), leading to odorant representations t

177 nd the output neurons mitral cells (MCs) and tufted cells (TCs).

178 endent lateral inhibition between mitral and tufted cells that likely reflect newly described differe

179 l glomeruli with light, we identified mitral/tufted cells that receive common input (sister cells).

180 tains excitatory principal cells (mitral and tufted cells) that project to cortical targets as well a

181 amic, 2-D, optogenetic stimulation of mitral/tufted cells, that virtual odors that differ by as littl

182 enhance intraglomerular inhibition of mitral/tufted cells, the main output neurons in the olfactory b

183 impact of glomerular circuits on mitral and tufted cells, the output channels of the olfactory bulb.

184 The activity of mitral and tufted cells, the principal neurons of the olfactory bul

185 that finely tune the activity of mitral and tufted cells, the principal neurons, and regulate odour

186 n and feedforward inhibition onto mitral and tufted cells, the principal neurons.

187 ays a role in the connectivity of mitral and tufted cells, the projection neurons in the mouse olfact

188 Mitral and tufted cells, the two classes of principal neurons in th

189 ly extracted from the activity of mitral and tufted cells-the output neurons of the olfactory bulb.

190 eurons of the olfactory bulb, the mitral and tufted cells then pass this information to the olfactory

191 ne to drive distinct responses of mitral and tufted cells to afferent-evoked input.

192 e circuit-level differences allow mitral and tufted cells to best discriminate odors in separate conc

193 he distinct responses of mitral and external tufted cells to high frequency stimulation did not origi

194 ypes of the mouse olfactory bulb (mitral and tufted cells) to decode odor identity and concentration

195 ayers in the olfactory bulb (OB), mitral and tufted cells, using chronic two-photon calcium imaging i

196 o the mitral layer and unit firing of mitral/tufted cells was phase locked to HFO.

197 esting that the larger peak EPSC in external tufted cells was the result of more synaptic contacts.

198 g the calcium indicator GCaMP2 in the mitral/tufted cells, we investigated the effect of ACh on the g

199 slices and glomerular stimulation of mitral/tufted cells, we observed two forms of action potential-

200 ow oscillations in mitral cells and external tufted cells were broader and had multiple peaks in OCAM

201 Tufted cells were devoid of Na beta 1 mRNA before P14, w

202 The RCMs indicated that mitral/tufted cells were excited by activation of a focal regio

203 d the superficial lamina Ia, labelled mitral/tufted cells were found distributed throughout the anter

204 tures represented by ensembles of mitral and tufted cells were overlapping but distinct from those re

205 naptic inputs that were targeted mainly onto tufted cells, which act as intermediaries in the excitat

206 rons in the mouse olfactory bulb, mitral and tufted cells, which send olfactory information to distin

207 ostsynaptic responses of mitral and external tufted cells within the glomerulus may involve both dire