ライフサイエンスコーパス: tumor microenvironment

1 tly excluding effector CD8+ T cells from the tumor microenvironment.

2 resulting in small electrical changes in the tumor microenvironment.

3 rrelates with gene expression of LGP2 in the tumor microenvironment.

4 une surveillance and sustain the suppressive tumor microenvironment.

5 arrow, which overcomes the immunosuppressive tumor microenvironment.

6 and immunosuppressive mechanisms within the tumor microenvironment.

7 munotherapy as a result of immunosuppressive tumor microenvironment.

8 ssociated with exclusion of T cells from the tumor microenvironment.

9 and increased adenosine levels characterize tumor microenvironment.

10 ession and effective immune responses in the tumor microenvironment.

11 ally depends on activation of T cells in the tumor microenvironment.

12 or inhibiting HSC activation and the hepatic tumor microenvironment.

13 plex macrophage function within the evolving tumor microenvironment.

14 files in both the gut lamina propria and the tumor microenvironment.

15 f cancer cell lines, which functioned as the tumor microenvironment.

16 nutrient-deficient conditions which resemble tumor microenvironment.

17 broblast-mediated collagen deposition in the tumor microenvironment.

18 on signatures associated with changes in the tumor microenvironment.

19 ely on the rapid immune responses within the tumor microenvironment.

20 that suggest the development of a malignant tumor microenvironment.

21 equent conversion of miPSCs into CSCs in the tumor microenvironment.

22 icacy and selectivity of Treg depletion in a tumor microenvironment.

23 ng to a role of complement in regulating the tumor microenvironment.

24 nular assessment of both tumor cells and the tumor microenvironment.

25 improve T effector cell accumulation in the tumor microenvironment.

26 etabolism, migration, and function in the 3D tumor microenvironment.

27 hrough the capacity to accumulate within the tumor microenvironment.

28 ion of the role of anaerobic bacteria in the tumor microenvironment.

29 n cellular and noncellular components of the tumor microenvironment.

30 ed with functional T cell recruitment to the tumor microenvironment.

31 portance because it acts as a barrier to the tumor microenvironment.

32 the phenotype of non-neoplastic cells in the tumor microenvironment.

33 uential and stage-specific manner within the tumor microenvironment.

34 tween tumor cells and immune cells shape the tumor microenvironment.

35 depletion of regulatory T cells (Treg) in a tumor microenvironment.

36 rcome immune suppression associated with the tumor microenvironment.

37 icines demands detailed understanding of the tumor microenvironment.

38 d responses in normal tissues as well as the tumor microenvironment.

39 osition and abundance of immune cells in the tumor microenvironment.

40 s on structure-function relationships in the tumor microenvironment.

41 factor (HGF) with the aim of disrupting the tumor microenvironment.

42 ubgroups characterized by differences in the tumor microenvironment.

43 nd metabolism in breast cancer cells and the tumor microenvironment.

44 stem cell production, and modulation of the tumor microenvironment.

45 th processes that depend on signals from the tumor microenvironment.

46 eloid cells, and other cell types within the tumor microenvironment.

47 molecular subtypes, all of which affect the tumor microenvironment.

48 cancers through change of cytokines and the tumor microenvironment.

49 ibroblast activation within the heterogenous tumor microenvironment.

50 esigning nanomedicine through exploiting the tumor microenvironment.

51 ibroblasts (CAFs) are a key component of the tumor microenvironment.

52 e inherently immunosuppressive nature of the tumor microenvironment.

53 uces the mobilization of immune cells in the tumor microenvironment.

54 of integrin function in tumor cells and the tumor microenvironment.

55 alpha, regulates TEM function in the hypoxic tumor microenvironment.

56 ment and are responsible for maintaining the tumor microenvironment.

57 key mediators of cellular cross-talk in the tumor microenvironment.

58 ype and degree of immune infiltration in the tumor microenvironment.

59 he oxygenation potential of HBOCs within the tumor microenvironment.

60 ic and epigenetic aberrations as well as the tumor microenvironment.

61 e strongly influenced by immune cells in the tumor microenvironment.

62 ucial for effector T cell recruitment to the tumor microenvironment.

63 healing, live lymph node sections and a live tumor microenvironment.

64 y CAFs as the specific source of FGF1 in the tumor microenvironment.

65 ions, epigenetic changes, and changes in the tumor microenvironment.

66 ect, even within a highly immune-suppressive tumor microenvironment.

67 types and increased stromal cells within the tumor microenvironment.

68 ow considered to be important players in the tumor microenvironment.

69 e to specific proteases overexpressed in the tumor microenvironment.

70 , tumor heterogeneity, and complexity of the tumor microenvironment.

71 c resistance and immunomodulation within the tumor microenvironment.

72 -Lindau) that leads to a highly vascularized tumor microenvironment.

73 rferon-primed exhausted CD8 + T-cells in the tumor microenvironment.

74 g within diverse cell types that compose the tumor microenvironment.

75 o thrive despite nutrient limitations in the tumor microenvironment.

76 ls and characterize the differences in their tumor microenvironment.

77 t effect on angiogensis, a key factor in the tumor microenvironment.

78 c cell populations reshape the immunological tumor microenvironment.

79 bundant hematopoietic cell type in the solid tumor microenvironment.

80 is and T regulatory cell distribution in the tumor microenvironment.

81 As in different environments such as hypoxic tumor microenvironments.

82 -risk for lung cancer pulmonary and the lung tumor microenvironments.

83 signaling pathways and interactions with the tumor microenvironment account for mantle cell lymphoma

84 ggered by various stimulating factors in the tumor microenvironment (acidic pH, reactive oxygen speci

85 e landscape characterization reveals diverse tumor microenvironments across and within diagnoses.

86 This allows them to locally reprogram the tumor microenvironment and activate antitumor immunity w

87 effectively modulates the immunosuppressive tumor microenvironment and activates innate immunity to

88 veal a link between lipid utilization in the tumor microenvironment and anti-tumor immunity in obese

89 a mediator of global T-cell responses in the tumor microenvironment and as a negative regulator of T-

90 e further shown to induce a pro-inflammatory tumor microenvironment and boost anti-tumor T cell activ

91 players in the accumulation of LMW-HA in the tumor microenvironment and cancer-related inflammation a

92 lasts represent an abundant cell type in the tumor microenvironment and have been linked to poor outc

93 n by local obesity-associated changes in the tumor microenvironment and implicate endocrine-exocrine

94 Platelets extravasated into the tumor microenvironment and interacted with tumor cells i

95 iew summarizes current understandings of the tumor microenvironment and intercellular communications

96 rget and respond to tumors via targeting the tumor microenvironment and intracellular signals is prov

97 ndothelial cell metabolism is altered in the tumor microenvironment and its effect in lymphangiogenic

98 archies, and describe the composition of the tumor microenvironment and its putative role in tumorige

99 sts (CAFs) are an important component of the tumor microenvironment and mediate tumor progression in

100 Moreover, ex vivo analysis of tumor microenvironment and NK cell phenotype was perform

101 Imaging of angiogenesis in the tumor microenvironment and of lymph nodes deep in the bo

102 of LXR in the transcriptional control of the tumor microenvironment and suggests use of a synthetic L

103 rogate the immune impact of radiation on the tumor microenvironment and test the hypothesis that radi

104 to extensive reprogramming of the pancreatic tumor microenvironment and that patients who progress on

105 Detailed understanding of the tumor microenvironment and the personalized design of up

106 Here, we discuss the properties of the tumor microenvironment and transport considerations for

107 e complexities of an in vivo solid tumor and tumor microenvironment, and are often used to study canc

108 cells by CD8(+) T cells is suppressed by the tumor microenvironment, and increased expression of inhi

109 d CAR-T cell infiltration, remodeling of the tumor microenvironment, and increased tumor sensitivity

110 as, increased macrophage infiltration in the tumor microenvironment, and shortened survival time in m

111 itochondria can engage in crosstalk with the tumor microenvironment, and signals from cancer-associat

112 lular signaling networks, their roles in the tumor microenvironment, and the consequences of posttran

113 can fuse with bystander neural cells in the tumor microenvironment; and cancer cell fusion is a dire

114 c, developmental, metabolic, epigenomic) and tumor microenvironment (angiogenesis, checkpoint regulat

115 istology-based stromal phenotypes within the tumor microenvironment are significantly associated with

116 fflux transporters, or components of complex tumor microenvironment are under intense investigation a

117 ated with increased immune activation in the tumor microenvironment as well as decreased adenovirus-r

118 ional immune response, especially within the tumor microenvironment, as normalization cancer immunoth

119 to stratify patient outcome on the basis of tumor-microenvironment associated genes.

120 c metabolic waste products accumulate in the tumor microenvironment because of high metabolic activit

121 esponse-assessment approach for studying the tumor microenvironment before or shortly after treatment

122 understand nano-bio interactions in not only tumor microenvironment but also entire body and develop

123 mmunosuppression and inflammation within the tumor microenvironment but is difficult to achieve due t

124 Mast cells (MCs) are part of tumor microenvironment, but the effect of hypoxia on the

125 the OXPHOS function might also influence the tumor microenvironment by alleviating hypoxia and improv

126 otes and maintains vascular integrity in the tumor microenvironment by contributing to the recruitmen

127 NR activity plays important roles in the tumor microenvironment by controlling inflammation and i

128 naling protein 1 (WISP1) to facilitate a pro-tumor microenvironment by promoting the survival of both

129 TGFbeta plays a crucial role in the tumor microenvironment by regulating cell-cell and cell-

130 ure or impaired immune system and inhibitory tumor microenvironment can further complicate the prospe

131 Blocking CD73 activity in the tumor microenvironment can have a beneficial effect on t

132 Cells within the tumor microenvironment can influence tumor progression;

133 Therapeutic irradiation of the tumor microenvironment causes differential activation of

134 When upregulated in the tumor microenvironment, CD73 has been implicated in the

135 Much of our understanding of the tumor microenvironment comes from in vitro studies isola

136 tic traits of cancer cells and of associated tumor microenvironment components have been shown to pro

137 IL-17 in cancer and provide insight into the tumor microenvironment conducive for successful IL-17-ba

138 ive macrophages that become activated in the tumor microenvironment constitutes a major factor respon

139 The tumor microenvironment contributes significantly to tumo

140 in interactions between tumor cells and the tumor microenvironment, contributing to metastasis.

141 e a hypoxic and acidic microenvironment, the tumor microenvironment coordinates a program that promot

142 onnegative Matrix Factorization-based Immune-TUmor MIcroenvironment Deconvolution (NITUMID) framework

143 The immunosuppressive state of the tumor microenvironment diminishes the efficacy of dendri

144 tes to fluoresce in the acidic extracellular tumor microenvironment due to the mechanism of nanoscale

145 n programs related to the cell-of-origin and tumor microenvironment effects confound the search for c

146 Interestingly, MFP treatment reshaped the tumor microenvironment, enhancing the production of proi

147 PDGFB and are continuously activated in the tumor microenvironment, exposing tumors to the plethora

148 esothelial cell-derived ITLN1 in the omental tumor microenvironment facilitates ovarian cancer progre

149 plications for understanding the role of the tumor microenvironment for macrophage activation.

150 to exploit the unique characteristics of the tumor microenvironment for precise targeting have been d

151 The immune function within the tumor microenvironment has become a prominent therapeuti

152 tial impact of NAD(+) depletion on the brain tumor microenvironment has not been elaborated.

153 e quality of the host immune response in the tumor microenvironment have been reported to have an imp

154 nd to exogenous or endogenous stimuli in the tumor microenvironment, have been widely investigated fo

155 turnover and decreases heterogeneity of the tumor microenvironment, hence PI3Kbeta inhibition may be

156 of the tumor and better understanding of the tumor microenvironment, immune checkpoint inhibitor ther

157 ne a new role for Notch3 in manipulating the tumor microenvironment in bone metastases.

158 CTGF is also involved in the tumor microenvironment in most of the nodes, including a

159 Despite the importance of the tumor microenvironment in regulating tumor progression,

160 5 cells, mice developed an immunosuppressive tumor microenvironment in the lung with increased freque

161 secretion of IFN-gamma, Cxcl9, and Cxcl10 in tumor microenvironment in vivo.

162 What is also changing is the battlefield-the tumor microenvironment including all noncancerous cells

163 cts on macrophages and CD4(+) T cells in the tumor microenvironment, inhibiting MAPK14 expression and

164 In the tumor microenvironment, inhibition of SHP2 modulated T-c

165 communication with important implications in tumor microenvironment interactions, tumor growth, and m

166 esource for generating hypotheses concerning tumor-microenvironment interactions that may have progno

167 to generate a novel resource called the Lung Tumor Microenvironment Interactome (LTMI).

168 mechanism underlies immunosuppression in the tumor microenvironment irrespective of the tumor type.

169 An emerging tumor microenvironment is a complex and continuously evo

170 onal state of the preexisting T cells in the tumor microenvironment is a key determinant for effectiv

171 er cells to ensure T-cell exclusion from the tumor microenvironment is a significant mechanism of res

172 such a potent immunotherapeutic agent in the tumor microenvironment is desired.

173 n stromal and immune cell subsets within the tumor microenvironment is hypothesized to represent an i

174 nteractions between components of the immune tumor microenvironment (iTME).

175 DON decreased hyaluronan and collagen in the tumor microenvironment, leading to an extensive remodeli

176 Acidosis of the tumor microenvironment leads to cancer invasion, progres

177 In the tumor microenvironment, local immune dysregulation is dr

178 Within the tumor microenvironment, macrophages exist in an immunosu

179 tic viruses and their ability to remodel the tumor microenvironment may help to recruit and potentiat

180 m for how KRas could alter cell responses to tumor microenvironment mechanics and may reveal chemothe

181 derstanding of intratumor heterogeneity, the tumor microenvironment, metastasis, and therapeutic resi

182 s bio-physicochemical characteristics of the tumor microenvironment, namely, acidic pH, redox reactan

183 otype of tumor-associated macrophages in the tumor microenvironment of advanced stage MF by upregulat

184 llular components to study the effect of the tumor microenvironment on immune cell recruitment.

185 he impact of tumor-derived EDN1 in modifying tumor microenvironment or contributing to drug resistanc

186 value of monitoring clonal constitution and tumor microenvironment over time to optimize ICB respons

187 osarcoma malignant cells together with their tumor microenvironment particularly stromal and immune c

188 ) has recently emerged as a modulator of the tumor microenvironment, paving the way for FUS to become

189 The tumor microenvironment plays a critical regulatory role

190 The tumor microenvironment plays a critical role in prostate

191 ed; however, recent studies suggest that the tumor microenvironment plays a key role in the progressi

192 lay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting

193 hey were shown to cooperate to regulate host tumor microenvironment programs including host immune re

194 racrine activation of cells contained in the tumor microenvironment promotes tumor progression and me

195 o estimate phenotypic growth and biophysical tumor microenvironment properties.

196 r-infiltrating lymphocytes (TILs) within the tumor microenvironment provides strong prognostic value,

197 eir ability to adapt and colonize lipid-rich tumor microenvironments, providing an opportunity for sp

198 vel bioactive molecules generated within the tumor microenvironment regulate signaling pathways in di

199 s that drive the immunologically restrictive tumor microenvironment remain poorly understood.

200 e crucial source of CD73 activity within the tumor microenvironment remains unspecified.

201 with HDAC6i induced critical changes in the tumor microenvironment, resulting in improved effectiven

202 Elements of the tumor microenvironment serve as therapeutic targets and

203 PD-L1 expression in the tumor microenvironment significantly correlated with pre

204 ile promoting M2-to-M1 repolarization within tumor microenvironment, significantly preventing both lo

205 SpAn infers the emergent network biology of tumor microenvironment spatial domains revealing a spati

206 We propose that increased tumor microenvironment stiffness leads to stromal cell-m

207 progression is influenced by changes in the tumor microenvironment, such as the stiffening of the ex

208 articularly dendritic cells, from the thymic tumor microenvironment support the survival and prolifer

209 of immune cell infiltrates or aspects of the tumor microenvironment that are known to be associated w

210 y, autoimmunity, and variable effects on the tumor microenvironment that can limit or worsen tumor pr

211 s a safe and robust means to alter an immune tumor microenvironment that could potentiate checkpoint

212 elopment of early lesions, to a desmoplastic tumor microenvironment that is highly fibrotic and immun

213 tionality and emerges as a key factor of the tumor microenvironment that promotes lymphomagenesis.

214 d by a highly stromal and weakly immunogenic tumor microenvironment that promotes tumor evolution and

215 These areas include the immune system, the tumor microenvironment, the fibrotic response, and stem

216 sor, nicotinamide mononucleotide (NMN), from tumor microenvironments, thereby enhancing tumor DNA rep

217 In the tumor microenvironment, this demonstrated a trajectory o

218 ss appears to establish an immunosuppressive tumor microenvironment through the activation of STAT3,

219 d role in inducing immune suppression in the tumor microenvironment, through both targeted inhibition

220 Immunosuppressive tumor microenvironment (TME) and ascites-derived spheroi

221 tics for remodeling of the immunosuppressive tumor microenvironment (TME) and enhancing response rate

222 ifferences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immun

223 c cancer, the degree of heterogeneity of the tumor microenvironment (TME) and its molecular underpinn

224 d benefit from a deeper understanding of the tumor microenvironment (TME) and its role in tumor progr

225 asts that constitute the major components of tumor microenvironment (TME) and play crucial roles in t

226 otes tumor progression and remodeling of the tumor microenvironment (TME) by sustaining the calcium t

227 owever, metabolic constraints imposed by the tumor microenvironment (TME) can dampen their ability to

228 nterplay of environmental factors within the tumor microenvironment (TME) can have a profound impact

229 ted NK cells are armed to combat tumors, the tumor microenvironment (TME) contains ROS, which suppres

230 , it is largely unknown how signals from the tumor microenvironment (TME) contribute to aberrant Zeb1

231 Macrophages within the tumor microenvironment (TME) exhibit a spectrum of protu

232 are key in establishing an immunosuppressive tumor microenvironment (TME) for the support of tumor gr

233 thods have been proposed recently to profile tumor microenvironment (TME) from bulk RNA data, and the

234 on signature (GES) or high immunosuppressive tumor microenvironment (TME) GES levels at baseline; an

235 Cherry-niche in cancer research to study the tumor microenvironment (TME) in metastasis.

236 We identified diverse cell types within the tumor microenvironment (TME) in which myeloid cells and

237 The tumor microenvironment (TME) is a complex neighborhood t

238 The tumor microenvironment (TME) is a highly complex environ

239 The immunosuppressive tumor microenvironment (TME) is a major barrier to immun

240 The tumor microenvironment (TME) is a potential target.

241 A non-immunogenic tumor microenvironment (TME) is a significant barrier to

242 The tumor microenvironment (TME) is an essential contributor

243 The tumor microenvironment (TME) is critical for tumor progr

244 The tumor microenvironment (TME) is increasingly appreciated

245 ch signaling within the breast tumor and its tumor microenvironment (TME) is linked to poor clinical

246 8 T cells are significantly decreased in the tumor microenvironment (TME) of GEM-treated mice.

247 h levels of OX40 (OX40+ pDC) enriched in the tumor microenvironment (TME) of head and neck squamous c

248 biological significance of the desmoplastic tumor microenvironment (TME) of ICC has been stressed bu

249 The tumor microenvironment (TME) plays a significant role in

250 The tumor microenvironment (TME) plays critical roles in tum

251 The tumor microenvironment (TME) promotes tumor development

252 Our understanding of the brain tumor microenvironment (TME) remains limited, and it is

253 Cellular interactions in the tumor microenvironment (TME) significantly govern cancer

254 Over 20,000 cancer and tumor microenvironment (TME) single-cell profiles expose

255 es have been limited by an immunosuppressive tumor microenvironment (TME) that prevents infiltrating

256 loid cells comprise a major component of the tumor microenvironment (TME) that promotes tumor growth

257 Identifying signals in the tumor microenvironment (TME) that shape CD8(+) T cell ph

258 eterogeneity is a fundamental feature of the tumor microenvironment (TME), and tackling spatial heter

259 timulation, recruitment of NK cells into the tumor microenvironment (TME), blockade of inhibitory rec

260 (ADO), present in high concentrations in the tumor microenvironment (TME), suppresses immune function

261 gene editing, and by targeting Mertk in the tumor microenvironment (TME), we observed distinct funct

262 enhance antitumor immunity by reshaping the tumor microenvironment (TME).

263 urgently needed to reverse the ICB-resistant tumor microenvironment (TME).

264 cytokine profiles into antitumor one in the tumor microenvironment (TME).

265 xpressing immunosuppressive cells within the tumor microenvironment (TME).

266 ese strategies in the context of the complex tumor microenvironment (TME).

267 understanding of the immune landscape of the tumor microenvironment (TME).

268 f reprogramming the highly immunosuppressive tumor microenvironment (TME).

269 noma and is believed to be secreted from the tumor microenvironment (TME).

270 tes to the formation of an immunosuppressive tumor microenvironment (TME).

271 lay a crucial role in generating TAMs in the tumor microenvironment (TME).

272 tential to accurately emulate the volumetric tumor microenvironment (TME).

273 nd activable nanomedicines that regulate the tumor microenvironment (TME).

274 sues reveals important information about the tumor microenvironment (TME).

275 w frequency of tumor-specific T cells in the tumor microenvironment (TME).

276 y cellular oncogene activation and a hostile tumor microenvironment (TME).

277 establish that the immunologic landscape and tumor microenvironments (TME) vary between different org

278 ation through deep profiling of inflammatory tumor microenvironments (TMEs) linked to immune-dependen

279 Solid tumors reside in harsh tumor microenvironments (TMEs) together with various str

280 n solid tumors can be limited by restrictive tumor microenvironments (TMEs).

281 via activation of GPR81 in cells present in tumor microenvironment to help tumor growth.

282 long-term gemcitabine administration on the tumor microenvironment to identify potential therapeutic

283 ncer stem cells), novel contributions of the tumor microenvironment to the uptake and regulation of i

284 In the tumor microenvironment, unusually high concentrations of

285 The composition of the tumor microenvironment varies between tumor types, but h

286 er, autophagy can play opposing roles in the tumor microenvironment via non-cell-autonomous mechanism

287 immune cells, while PD-L1 expression in the tumor microenvironment was assessed.

288 produces a signal only in the protease-rich tumor microenvironment, was topically applied to 90 spec

289 To remodel the tumor microenvironment, we developed a liposome formulat

290 rapy outcomes and tumor growth patterns in a tumor microenvironment, we developed and analyzed an int

291 derived suppressor cells (MDSCs) within the tumor microenvironment, when compared with Lys-SNAs and

292 migration of circulating monocytes into the tumor microenvironment, where they mature into tumor-ass

293 ene expression in multiple cell types of the tumor microenvironment, which could contribute to angiog

294 ma progression involves acidification of the tumor microenvironment, which is an important factor for

295 Hypoxia is a common feature of the tumor microenvironment, which is characterized by tissue

296 mmunogenic and exceedingly immunosuppressive tumor microenvironment, which is enriched with dysfuncti

297 d increased dendritic cell activation in the tumor microenvironment, which were further amplified upo

298 rategy induces reversal of immunosuppressive tumor microenvironment, while enhancing effective anti-t

299 ing the effects of novel cancer drugs on the tumor microenvironment will be crucial for their success

300 approach to targeting the immunosuppressive tumor microenvironment with monoclonal antibodies to enh