ライフサイエンスコーパス: tumor-promoting

1 lymphatic vessels and macrophages to be less tumor promoting.

2 a signaling shifts from tumor suppressive to tumor promoting.

3 eous skin tumors and are highly sensitive to tumor-promoting 7,12-dimethylbenzanthracene/12-O-tetrade

4 ls, a population of cancer cells with strong tumor-promoting ability.

5 er cell proliferation and account for IMP2's tumor promoting action.

6 The cytokine IL6 has a number of tumor-promoting activities in human and experimental can

7 ribute to the opposing tumor-suppressive and tumor-promoting activities of these PKC family members i

8 rotein, promoting both tumor-suppressive and tumor-promoting activities.

9 ed recruitment of macrophages with prominent tumor-promoting activities.

10 ponent of the tumor stroma and exert several tumor-promoting activities.

11 and associated with poor survival as well as tumor-promoting activities.

12 s acts as a fail-safe mechanism to limit the tumor promoting activity of AID when it overwhelms uraci

13 inflammatory IL6 has both local and systemic tumor-promoting activity in many cancers, including ovar

14 Overall, our results reveal an unexpected tumor-promoting activity of activated NRF2 during early

15 cancer development, as a determinant for the tumor-promoting activity of cancer-associated fibroblast

16 The tumor-promoting activity of epithelial p38gamma was furt

17 Ms is downstream of FLT1 and can restore the tumor-promoting activity of FLT1-inhibited MAMs.

18 y concurrent LSD1 depletion, indicating that tumor-promoting activity of HDAC5 is an LSD1 dependent f

19 of this residue to phenylalanine reduced the tumor-promoting activity of p21 in the animal model, whe

20 with the in vivo data demonstrating a strong tumor-promoting activity of PRR14 and the mutants, our w

21 ating that VN binding is responsible for the tumor-promoting activity of uPAR in vivo.

22 tly needed to investigate how to inhibit the tumor-promoting activity of WAT cells and progenitors.

23 Par3 mediates its tumor-promoting activity through regulation of growth an

24 id metabolism is distinct and separable from tumor-promoting activity.

25 data from mouse tumor models, non-mutagenic tumor-promoting agents have been posited to activate the

26 on from acute, tumor-suppressive to chronic, tumor-promoting allergic contact dermatitis (ACD) reveal

27 ssociated AT by facilitating accumulation of tumor-promoting alternatively activated macrophages.

28 emonstrate an important role for JNK2 in the tumor promoting an invasive capacity of EGFR variant III

29 special focus on the metabolic modulation of tumor promoting and suppressing pathways and, conversely

30 er is not understood, as both AMPK-dependent tumor-promoting and -inhibiting functions were reported.

31 ptors, and discuss the evidence for DAMPs as tumor-promoting and anti-tumor effectors, as well as uns

32 ssed here how it is regulated in response to tumor-promoting and antigen-mimicking signals.

33 we describe that TAMs require ZEB1 for their tumor-promoting and chemotherapy resistance functions in

34 Also, four members of the tumor-promoting and HSF1-associated phosphatidylinositol

35 , our studies suggest that inhibition of the tumor-promoting and immune-suppressive functions of MDSC

36 in response to IFNgamma, M-MDSCs release the tumor-promoting and immunosuppressive molecule nitric ox

37 We also review the tumor-promoting and tumor-suppressing consequences of W-

38 epigenetic modifications that can have both tumor-promoting and tumor-suppressing effects.

39 The balance between tumor-promoting and tumor-suppressing immune responses a

40 of the tumor microenvironment and have both tumor-promoting and tumor-suppressive functions.

41 CXCR2 has been suggested to have both tumor-promoting and tumor-suppressive properties.

42 t least in part, through modulating multiple tumor-promoting autocrine/paracrine factors.

43 n of AR3 modulates expression of a number of tumor-promoting autocrine/paracrine growth factors (incl

44 (LSC) retention and growth in the remodeled tumor-promoting BM is unclear.

45 en translation is not necessarily inherently tumor promoting but instead can manage widespread oncoge

46 iators accompanied by aberrant activation of tumor-promoting c-JUN and STAT3 signaling cascades, and

47 ormal tissue fibroblasts are reprogrammed to tumor-promoting CAFs are mainly obscure.

48 ntin in reprograming normal fibroblasts into tumor-promoting CAFs.

49 gumain, is highly expressed in various solid tumors, promoting cancer cell invasion, migration, and m

50 cell carcinoma (OSCC) that have differential tumor-promoting capability, one with a transcriptome and

51 ols, we show that NKG2D self-stimulation has tumor-promoting capacity.

52 ical for macrophage populations with reduced tumor-promoting capacity.

53 isulfiram/copper ion chelate repolarized the tumor-promoting CD206(hi) TGF-beta1(+) MPhi via inhibiti

54 Our results indicate that Osx marks distinct tumor promoting CD45- and CD45+ populations and challeng

55 version of progenitor smooth muscle cells to tumor-promoting cells.

56 r-associated macrophages (TAM) are important tumor-promoting cells.

57 at tumorigenesis occurs when tissue-specific tumor-promoting changes are formed through these events.

58 r microenvironment and is accompanied by key tumor-promoting changes in the extracellular matrix prot

59 lergic contact dermatitis (ACD) revealed how tumor-promoting chronic inflammation develops.

60 om diet or environment are associated with a tumor-promoting colonic milieu as reflected by the high

61 e histone methyltransferase Setd2 had robust tumor-promoting consequences.

62 uced influx of leukocytes and down regulated tumor-promoting cyto-/chemokine profile in bronchoalveol

63 own-regulated the synthesis and secretion of tumor-promoting cytokines and chemokines into the bronch

64 Expression and secretion of multiple tumor-promoting cytokines or chemokines in the liver wer

65 expression of T-cell exhaustion markers and tumor-promoting cytokines.

66 with significantly higher concentrations of tumor-promoting deoxycholic acid (26.7 +/- 4.2 compared

67 possible target for reducing fibrosis in the tumor-promoting dermal microenvironment of RDEB patients

68 precise ECM manipulations, such as targeting tumor-promoting ECM proteins and their regulators in can

69 The tumor promoting effect of PKCalpha loss was reflected in

70 8:1, which we previously showed to possess a tumor promoting effect, was significantly elevated in pa

71 Targeting these cells to inhibit their tumor-promoting effect and reprogramming them into an an

72 Interestingly, this tumor-promoting effect by p53-deficient MSCs was not obs

73 n of other regulators; therefore, this FOG-3 tumor-promoting effect is context dependent.

74 We further showed that the transmission of tumor-promoting effect is partially mediated by soluble

75 -mediated and HBsTg-driven HCG, suggesting a tumor-promoting effect of BID.

76 elevated CCL-2 expression in BM-L-MSCs, the tumor-promoting effect of BM-L-MSCs largely depends on C

77 une functions of complement proteins and the tumor-promoting effect of complement activation.

78 1 in response to stress, indicating that the tumor-promoting effect of E2F7/8 inactivation can be par

79 We demonstrated the tumor-promoting effect of hypoxia on tumor initiation in

80 and on mechanisms that may contribute to the tumor-promoting effect of MCs in animals, including the

81 an lung carcinoma H460 cells, suggesting the tumor-promoting effect of PMMTM.

82 Unexpectedly, the tumor-promoting effect of tissue injury also requires c-

83 Furthermore, we localized the tumor-promoting effect to a 115-amino acid region in sec

84 roduction and anti-IL-23 mAbs to counter the tumor promoting effects of IL-23 has greater antitumor a

85 Finally, we identify that AEBP1 exerts its tumor-promoting effects by mainly activating mTOR pathwa

86 Mechanistically, ALKBH5 exerts tumor-promoting effects in AML by post-transcriptional r

87 a major downstream effector of PI3K and has tumor-promoting effects in prostate cancer.

88 Interestingly, the mammary tumor-promoting effects of a Cav-1-deficient microenviro

89 be solely due to positive selection for the tumor-promoting effects of amplified gene products.

90 CXCR2 silencing in CSCs abolished the tumor-promoting effects of endothelial cells in vivo, co

91 cidate molecular mechanisms underpinning the tumor-promoting effects of GPNMB in this context, we int

92 Mechanistically, we attributed the tumor-promoting effects of Ikkepsilon to limited TNF-dep

93 for Akt and Erk activation in mediating the tumor-promoting effects of IL4Ralpha.

94 rophage integrin beta3 signaling blocked the tumor-promoting effects of integrin beta3 antagonism.

95 provides novel mechanistic insight into the tumor-promoting effects of KHSRP in CRC.

96 Mechanistic investigations revealed that the tumor-promoting effects of Nestin were mediated by bindi

97 Conclusion The tumor-promoting effects of obesity occur at the local le

98 Tumor-promoting effects of obesity occur locally via adi

99 These results contrast with known tumor-promoting effects of PADI4 on the tumor stroma and

100 orm-specific binding proteins to clarify the tumor-promoting effects of RhoA and C that contrast with

101 Our findings suggest that indirect tumor-promoting effects of testosterone likely explain t

102 to the immunosuppressive, proangiogenic, and tumor-promoting effects of this pleiotropic effector in

103 evealed that FGF1 is sufficient to drive the tumor-promoting effects of WNT7A.

104 Aldob R304A mutant restores Akt activity and tumor-promoting effects.

105 o, whereas PEDF-depleted fibroblasts exerted tumor-promoting effects.

106 ell population through apoptosis could yield tumor-promoting effects.

107 ation in the tumor microenvironment has many tumor-promoting effects.

108 atment of V33 Apc (Min/+) mice abrogated the tumor promoting-effects of IL-33 in the colon.

109 ntestinal lamina propria, thereby favoring a tumor-promoting environment.

110 ibiting pro-apoptotic signals and activating tumor-promoting ER stress-induced unfolded protein respo

111 Further tumor promoting events are required to unleash their car

112 ozygous microdeletions, PDE4D functions as a tumor-promoting factor and represents a unique targetabl

113 ted recruitment of neutrophils secreting the tumor-promoting factor APRIL mediates DLBCL progression.

114 Lysophosphatidic acid (LPA), a major tumor-promoting factor in EOC ascites, is an enzymatic p

115 d EWS-FLI1, is also characterized as a novel tumor-promoting factor in this malignancy.

116 esized that autophagy-dependent secretion of tumor-promoting factors by HNSCC-associated CAFs may exp

117 lular source influences the function of such tumor-promoting factors remains an open question.

118 TGFbeta stimulation promoted HSCs to express tumor-promoting factors, and alpha-smooth muscle actin,

119 vitro, suggesting the existence of secreted tumor-promoting factors.

120 rin alpha11/PDGFRbeta+ CAF subset displaying tumor-promoting features in BC.

121 e, we reported that nintedanib inhibited the tumor-promoting fibrotic phenotype of TAFs selectively i

122 The tumor-promoting fibrotic stroma rich in tumor-associated

123 usive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbo

124 results indicated that miR-21/AR mediate its tumor-promoting function by attenuating TGFbeta-mediated

125 ults advance our understanding of ST6Gal-I's tumor-promoting function by highlighting a role for ST6G

126 In contrast, we have uncovered a potent tumor-promoting function for Arkadia.

127 These results identify a novel tumor-promoting function for IGFBP2 of activating EGFR/S

128 Our findings reveal a non-cell-intrinsic, tumor-promoting function for Tet2 and suggest that Tet2

129 Our results establish a tumor-promoting function for Treg during CAC formation,

130 Here, we show the tumor-promoting function of a cell cycle-related protein

131 We provide evidence that the tumor-promoting function of BID in CLI is not related to

132 with prognostic clinical data, we found the tumor-promoting function of DLL1 is exclusive to ERalpha

133 The tumor-promoting function of lal(-/-) MDSCs is mediated,

134 mediators responsible for expansion and the tumor-promoting function of MDSCs, we discovered CCAAT/e

135 nstream targeting studies, we found that the tumor-promoting function of miR-4516, in part, was media

136 ur findings reveal a previously unrecognized tumor-promoting function of RNF8 and provide evidence th

137 suggest that tumor cell-derived ANGPTL2 has tumor-promoting function.

138 le in cancer by focusing on key enzymes with tumor-promoting functions and important products of the

139 ancer-associated fibroblasts (CAF) have many tumor-promoting functions and promote immune evasion thr

140 is beginning to emerge, with the notion that tumor-promoting functions are attributed to its products

141 et, a clear mechanism by which SEPT9 elicits tumor-promoting functions is lacking.

142 Interestingly, several of the tumor-promoting functions of CtsZ were not dependent on

143 nsatory protease that regulates the acquired tumor-promoting functions of lesions deficient in both C

144 e demonstrate that the tumor-suppressing and tumor-promoting functions of the p38-PRAK pathway are te

145 s on their immune-suppressive activities and tumor-promoting functions, as well as the relevance to p

146 r microenvironment and for maintaining TAMs' tumor-promoting functions.

147 (YBX1) is a well known oncoprotein that has tumor-promoting functions.

148 ving TAMs, which is consistent with impaired tumor-promoting functions.

149 nables them to perform immunosuppressive and tumor-promoting functions.

150 ted kinase 1A, was a potent megakaryoblastic tumor-promoting gene that contributed to leukemogenesis

151 tumor growth and metastasis via influencing tumor promoting genes DEK and SHP2.

152 d with enhanced transcription of a subset of tumor promoting genes such as CHPT1, which catalyzes pho

153 Putative tumor-promoting genes and lncRNAs defined using BGRDs ar

154 nism by which LMP1 drives expression of host tumor-promoting genes by blocking generation of the inhi

155 for HSF1 in promoting mRNA transcription of tumor-promoting genes has been suggested, it appears tha

156 These stress-responsive and tumor-promoting genes in turn alter the ability of tumor

157 d HCC, resulting in the induction of various tumor-promoting genes, including indoleamine 2,3-dioxyge

158 ndogenous ligand anandamide, and a number of tumor-promoting genes, including the GRB2 interactome as

159 se that loss of CTCF-dependent imprinting of tumor-promoting genes, such as IGF2 and TERT, results fr

160 e growth of cancer fragments and upregulated tumor-promoting genes, such as Runx2, MMP9, and Snail.

161 esis of enhancer RNAs, and the activation of tumor-promoting genes.

162 l coactivator of proliferation-promoting and tumor-promoting genes; when confluent, active/nuclear YA

163 PIK3Cbeta(D1067V) might function as a novel tumor-promoting genetic alteration, and potentially an o

164 This work indicates that NS constitutes a tumor-promoting genome maintenance program required for

165 B7-H3 is a tumor-promoting glycoprotein that is expressed at low le

166 plays a critical role in perpetuating these tumor-promoting hallmarks but also in developing antitum

167 tumors; whereas low rates of CIN are weakly tumor promoting, higher rates of CIN cause cell death an

168 sm by which LMP1 regulates the expression of tumor-promoting host genes.

169 de cortex, interact with B cells, and foster tumor-promoting humoral immunity.

170 gh IL-23 and TGF-beta, and induce FoxP3(neg) tumor-promoting IL-10(+)IL-17(+)IFNgamma(+ )regulatory C

171 EAC arise from gastric progenitors due to a tumor-promoting IL-1beta-IL-6 signaling cascade and Dll1

172 rleukin [IL] 10, CC chemokine ligand 18) and tumor-promoting (IL-6, IL-8) cytokines.

173 microglia (TAMs) have been found to be major tumor-promoting immune cells in the tumor microenvironme

174 from acute to chronic ACD and triggered the tumor-promoting immune environment in chronic ACD.

175 he role of the IL-33/Treg axis in creating a tumor-promoting immune environment in chronic inflammato

176 regs was required for the development of the tumor-promoting immune environment in the skin.

177 A similar tumor-promoting immune environment was detected in SCCs

178 hat attract and differentiate monocytes into tumor-promoting, immune-suppressing M2-like macrophages.

179 ors; however, their presence and role in the tumor-promoting, immune-suppressive microenvironment in

180 ophagy can be neutral, tumor-suppressive, or tumor-promoting in different contexts.

181 In cancer biology, tumor-promoting inflammation and an inflammatory microen

182 rate that CD14-high BC cells may orchestrate tumor-promoting inflammation and drive tumor cell prolif

183 matory pathway might be critical in reducing tumor-promoting inflammation and lung cancer incidence.

184 lso increasingly recognized as regulators of tumor-promoting inflammation and promoters of tumor surv

185 et of TLR9/STAT3-regulated genes involved in tumor-promoting inflammation and revascularization.

186 We discuss how tumor-promoting inflammation closely resembles inflammat

187 CAF also orchestrate tumor-promoting inflammation in multiple tumor types, in

188 sponses initiated via this receptor generate tumor-promoting inflammation or antitumor immunity remai

189 Importantly, we found similar tumor-promoting inflammation surrounding the SCC in our

190 testinal barrier disruption is the origin of tumor-promoting inflammation that acts in conjunction wi

191 verning molecular and cellular mechanisms of tumor-promoting inflammation will be essential for furth

192 While attenuating tumor-promoting inflammation, autophagy enhances the pro

193 clude developing strategies for neutralizing tumor-promoting inflammation, broadening T-cell repertoi

194 owth of surviving malignant cells by fueling tumor-promoting inflammation.

195 ia the IL-22 receptor, resulting in enhanced tumor-promoting inflammation.

196 ndin E2, which suppresses immunity and fuels tumor-promoting inflammation.

197 Complement-dependent, macrophage-sustained, tumor-promoting inflammation.

198 c stellate cells, and are a key component of tumor-promoting inflammation.

199 riven tumorigenesis, even in the presence of tumor-promoting inflammation.

200 show that this is not due to differences in tumor-promoting inflammatory changes or variability in i

201 ellular senescence, which was accompanied by tumor-promoting inflammatory cytokine expression and acq

202 how that LRP5/6 suppresses the expression of tumor-promoting inflammatory factors in CD11c(+) APCs vi

203 ice from CAC by regulating the expression of tumor-promoting inflammatory factors in response to comm

204 ts behind the mechanisms that establish this tumor-promoting inflammatory microenvironment remain und

205 will be an important mechanism to dampen the tumor-promoting inflammatory response and inhibit cancer

206 Thus, suggesting a tumor-promoting influence on a broad range of CRC.

207 sure (or GSK-3beta inhibition) is blocked by tumor-promoting isoforms of APC that reduce an interacti

208 emokine receptor that directs recruitment of tumor-promoting leukocytes into tissues during tumor-ind

209 scade, the recruitment and activity of other tumor-promoting leukocytes, and tumor responses to front

210 our results demonstrate that PRL constrains tumor-promoting liver inflammation by inhibiting MAP3K-d

211 found 3 congenic strains that each harbored tumor promoting loci that had high (14%-32%) whereas 2 o

212 an important subset of immunosuppressive and tumor-promoting lymphocytes.

213 a mechanism for macrophage polarization into tumor-promoting M2 cells.

214 noma and breast cancer growth with increased tumor-promoting M2 macrophages and decreased CD8(+) T ce

215 est that a chemotherapy-mediated increase in tumor-promoting M2 macrophages may form an indirect mech

216 nown to skew differentiation of monocytes to tumor-promoting M2 macrophages.

217 ent macrophages showed a propensity toward a tumor-promoting M2 polarization, indicating a secondary

218 stimulate polarization of macrophages into a tumor-promoting M2-state and enhance the proliferation o

219 Complement activation, CCL2 production, and tumor-promoting macrophage recruitment.

220 ding an optimal probe for PET imaging of the tumor-promoting macrophage subpopulation in the tumor st

221 microenvironment showed high infiltration of tumor-promoting macrophages with high expression of the

222 of monocytes and their differentiation into tumor-promoting macrophages.

223 ma cells not only activate expression of the tumor-promoting matrix metalloproteinases MMP2 and MMP12

224 C development and may constitute the primary tumor-promoting mechanism through which TCS acts.

225 clear causal role in cancer development, the tumor-promoting mechanisms of IGFBP2 are poorly understo

226 tween epithelial reactive oxygen species and tumor-promoting microbiota requires a 2-pronged strategy

227 o inhibit redox homeostasis and modulate the tumor promoting microenvironment of basal-like and BRCA1

228 in the induction of an immunosuppressive and tumor-promoting microenvironment of CLL.

229 AMs infiltration in lung cancer to provide a tumor-promoting microenvironment, which validates neddyl

230 diovascular disease, and fibrosis and in the tumor-promoting microenvironment.

231 munication in cancer, including by conveying tumor-promoting microRNAs between cells, but their regul

232 Using a tumor-promoting model combining chronic Helicobacter hep

233 renders neoplastic growth and translation of tumor-promoting mRNAs refractory to mTOR inhibition.

234 ation of highly structured proliferation and tumor-promoting mRNAs.

235 initially counter-intuitive fact that using tumor-promoting MSCs as carriers is not only helpful but

236 hLAL expression reduced tumor-promoting myeloid-derived suppressive cells in the

237 on in lung epithelial cells not only reduced tumor-promoting myeloid-derived suppressor cells in the

238 iation of hepatic stellate cells (HSCs) into tumor-promoting myofibroblasts but underlying mechanisms

239 s of esophageal SCC, shedding light upon the tumor promoting oncogenic aspect of Notch1 in SCC.

240 the behavior of neoplastic cells in either a tumor-promoting or tumor-inhibiting manner.

241 monstrate a global overlap in the binding of tumor-promoting p53 mutants and the master proinflammato

242 ls to metformin leads to hypermethylation of tumor-promoting pathway genes and concomitant inhibition

243 A strategy for disrupting this tumor-promoting pathway is silencing TGF-beta by siRNA.

244 results suggest that Id-1 regulates multiple tumor-promoting pathways in glioblastoma and that drugs

245 table; therefore, epigenetic deregulation of tumor-promoting pathways is required for tumorigenesis.

246 CF(3)DODA-Me in abrogating several of these tumor-promoting pathways.

247 ls recruit and educate macrophages into a M2 tumor-promoting phenotype that supports the metastatic s

248 e (TAM) recruitment and acquisition of an M2 tumor-promoting phenotype.

249 domain that binds diacylglycerol as well as tumor-promoting phorbol esters and a catalytic GAP domai

250 rine/threonine kinases are major targets for tumor-promoting phorbol esters, G protein-coupled recept

251 sed in cells stimulated by growth factors or tumor-promoting phorbol esters, we analyzed its role in

252 ST6Gal-I activity augments the expression of tumor-promoting pNFkappaB transcriptional targets such a

253 Chronic inflammation's tumor-promoting potential is well-recognized; however, t

254 naling under glucose shortage to amplify its tumor-promoting potential.

255 Our data indicate that PINK1 has tumor-promoting properties and demonstrates a new functi

256 s on global gene expression and suppress CAF tumor-promoting properties in an in vivo model of squamo

257 bility and resistance upon therapy, and have tumor-promoting properties in in vivo models.

258 gely neglected for ACT due to their reported tumor-promoting properties.

259 ve stroma co-evolves with cancer, exhibiting tumor-promoting properties.

260 itive regulator of MDM2, consistent with its tumor-promoting property as knockdown of NFATc3 retarded

261 Knocking down NLRP1 revealed a tumor-promoting property of NLRP1 both in vitro and in v

262 ma resident MSCs (L-MSCs) are able to confer tumor-promoting property to the naive cocultured BM-MSCs

263 and regulate protein phosphatase 4 (PP4), a tumor-promoting protein, but not the related protein pho

264 e cells are activated to signal via multiple tumor-promoting reparatory, trophic, angiogenic, tissue

265 type-specific key regulator and uncovered a tumor promoting role of IRF5.

266 ma and colon and breast cancer, suggesting a tumor-promoting role for C3aR signaling in a range of tu

267 Our findings establish a tumor-promoting role for TCF7L1 in skin and elucidate th

268 ecedes and promotes metastasis, indicating a tumor-promoting role for TDLN B cells.

269 previous observations are consistent with a tumor-promoting role for these cytokines, particularly C

270 demonstrate that Prx type II (PrxII) plays a tumor-promoting role in colorectal cancer by interacting

271 ved by other cavins such as cavin-2, and the tumor-promoting role of cavin-1 in pancreatic cancer was

272 Here, we uncovered an unexpected tumor-promoting role of DDR in cancer cell reprogramming

273 In agreement with the ovarian tumor-promoting role of Neu5Ac, treatment with Neu5Ac-ta

274 Our study demonstrates a tumor-promoting role of NLRP1 in cancer cells.

275 ctivated Smads/YAP/TAZ complex abrogated the tumor-promoting role of P. gingivalis.

276 Together, our results demonstrate a major tumor-promoting role of T reg cells in an autochthonous

277 ted alternative splicing is essential to the tumor-promoting role of TGF-beta and has a global influe

278 in cis, and we present evidence supporting a tumor-promoting role.

279 ncies, however, HIF1alpha has an established tumor-promoting role.

280 tumor models, granulocytes appear to play a tumor-promoting role.

281 cells slowed tRCC progression, supporting a tumor-promoting role.

282 on these data, it appears that OPG may have tumor-promoting roles in the pathogenesis of lymphangiol

283 tudies have identified tumor-restricting and tumor-promoting roles of PDAC-associated desmoplasia, su

284 , we evaluate the evidence to support direct tumor-promoting roles of these cytokines.

285 upporting stroma and with well characterized tumor-promoting roles.

286 address both potential tumor-suppressive and tumor-promoting roles.

287 Here we hypothesize that the tumor-promoting side of genome maintenance programs may

288 ated macrophages, resulting in activation of tumor-promoting signaling and acceleration of breast tum

289 Indeed, Wnt5a overexpression associated with tumor-promoting stem-like characteristics (TPC) in defin

290 came highly tumorigenic when challenged with tumor-promoting stimuli, suggesting that tumors in LKO m

291 ctivated murine dendritic cells (DCs) into a tumor-promoting suppressive phenotype.

292 Preventing the accumulation of tumor-promoting T cells or enhancing the recruitment of

293 s the differentiation of CD4(+) T cells into tumor-promoting T helper type 2 cell (Th2 cell), Th17 ce

294 uence of the tumor microenvironment regulate tumor-promoting Th2 inflammation in PDAC, helping in ill

295 as shown to switch macrophage phenotype from tumor promoting to tumor suppressing.

296 ester (CDDO-Me) converts breast TAMs from a tumor-promoting to a tumor-inhibiting activation state i

297 g tumor-associated macrophage phenotype from tumor-promoting to tumor-suppressive status; using cellu

298 PD-L1(+) T cells exerted tumor-promoting tolerance via three distinct mechanisms:

299 that ST6Gal-I induced expression of the key tumor-promoting transcription factors, Sox9 and Slug.

300 cing factor CAPERalpha regulates splicing of tumor-promoting VEGF isoforms, yet the molecular target