ライフサイエンスコーパス: tyrosinase-related protein

1 of the melanocyte, possibly tyrosinase or a tyrosinase-related protein.

2 ified, forming a family of proteins known as tyrosinase related proteins.

3 ified, forming a family of proteins known as tyrosinase-related proteins.

4 been conserved in vertebrate tyrosinases and tyrosinase-related proteins.

5 g was done, using tyrosinase (PBD: 2Y9X) and tyrosinase related protein 1 (PBD: 5M8P).

6 ther lentivector delivering a self/tumor Ag, tyrosinase related protein 1 (TRP1), could stimulate eff

7 Here, we identify Tyrosinase Related Protein 1 (TYRP1) as a CAR-T cell the

8 % of vesicles demonstrated colocalization of tyrosinase related protein 1 and 3-(2, 4-dinitroanilino)

9 (pJ/pJ and pcp/p6H) showed colocalization of tyrosinase related protein 1 and 3-(2,4-dinitroanilino)-

10 erum directed against the melanosomal marker tyrosinase related protein 1.

11 ses to a melanocyte differentiation antigen, tyrosinase-related protein 1 (or gp75), which is the pro

12 to controlling tyrosinase (albino locus) and tyrosinase-related protein 1 (TR-P1/gp75/brown locus), b

13 ch CD4+ T cells recognize a novel epitope in tyrosinase-related protein 1 (TRP-1), an antigen express

14 , including the self-antigen and melanoma Ag tyrosinase-related protein 1 (TRP1).

15 ssing of melanocyte differentiation antigen, tyrosinase-related protein 1 (TRP1).

16 ed by a low-affinity MHC class I ligand from tyrosinase-related protein 1 (TRP1).

17 eine change at a highly conserved residue in tyrosinase-related protein 1 (TYRP1) as a major determin

18 t a missense alteration in the gene encoding tyrosinase-related protein 1 (TYRP1) likely interferes w

19 identified a missense alteration (R153C) in Tyrosinase-related protein 1 (TYRP1) that likely affects

20 erved in the number of NC-Ms [melanin(+) and tyrosinase-related protein 1 (TYRP1)(+) cells], the diff

21 fficking of a known AP-3 cargo, CD63, and of tyrosinase-related protein 1 (Tyrp1), a melanosomal memb

22 similar in color to mice with a mutation in tyrosinase-related protein 1 (Tyrp1), a mouse model for

23 chromosome 2 where a strong candidate gene, tyrosinase-related protein 1 (TYRP1), has also been mapp

24 c for the melanocyte differentiation antigen tyrosinase-related protein 1 (Tyrp1), then constructed b

25 uestions, a mutated self-antigen, designated tyrosinase-related protein 1 (Tyrp1)-WM, derived from Ty

26 rane lacked the melanosomal membrane protein tyrosinase-related protein 1 (TYRP1).

27 dendritic morphology and down-regulation of tyrosinase-related protein 1 (TYRP1/gp75), a melanocyte

28 In treated melanocytes, tyrosinase and tyrosinase-related protein 1 accumulated in Lamp-1-posit

29 th tyrosinase, two other pigmentation genes, tyrosinase-related protein 1 and Dopachrome-tautomerase

30 Both BRG1 and Mitf could be localized to the tyrosinase-related protein 1 and tyrosinase promoters by

31 recognized an epitope expressed in both the tyrosinase-related protein 1 and tyrosinase-related prot

32 ab27b colocalizes with the melanosome marker tyrosinase-related protein 1 and with myosin Va at the c

33 on in A-188 cells caused both tyrosinase and tyrosinase-related protein 1 to be localized to large gr

34 esults in mistranslocation of tyrosinase and tyrosinase-related protein 1 to large granular complexes

35 proteins (including TYR (tyrosinase), TYRP1 (tyrosinase-related protein 1), DCT (tyrosinase-related p

36 associated with mutations in TYRP1 (encoding tyrosinase-related protein 1).

37 Activation of tyrosinase-related protein 1, a melanocyte-specific gene

38 perinuclear vesicles carrying tyrosinase and tyrosinase-related protein 1, consistent with a role in

39 was 100% penetrance in the progeny from the tyrosinase-related protein 1-mGluR5 lines generated from

40 genic marker proteins such as tyrosinase and tyrosinase-related protein 1.

41 lines under a melanocyte-specific promoter, tyrosinase-related protein 1.

42 by the presence of wild type tyrosinase and tyrosinase-related protein 1.

43 Tumors expressed tyrosinase-related proteins 1 and 2 but not tyrosinase,

44 I-IV melanoma were assessed for tyrosinase, tyrosinase-related proteins 1 and 2, Pmel 17, and MART-1

45 ion, including those encoding tyrosinase and tyrosinase-related proteins 1 and 2.

46 Tyrosinase- related protein-1 (TRP-1) was not detected i

47 A human tyrosinase-related protein-1 (TRP-1) cDNA was inserted i

48 epitope (ISPNSVFSQWRVVCDSLEDYD) derived from tyrosinase-related protein-1 (TRP-1) using a predictive

49 iated antigens, glycoprotein 100 (gp100) and tyrosinase-related protein-1 (TRP-1), respectively, into

50 g of the melanogenic proteins tyrosinase and tyrosinase-related protein-1 (TRP-1).

51 st the melanosome membrane glycoprotein gp75/tyrosinase-related protein-1 (TYRP-1) of melanocytes lea

52 melanin synthesis and expression/activity of tyrosinase-related protein-1 (Tyrp-1).

53 ressing Cre-recombinase under control of the tyrosinase-related protein-1 (Tyrp1) promoter, which is

54 lanocytes accumulate the melanosomal protein tyrosinase-related protein-1 (Tyrp1), but not other mela

55 Tyrosinase, tyrosinase-related protein-1 (Tyrp1), dopachrome tautome

56 c tissue self antigen expressed by melanoma, tyrosinase-related protein-1 (Tyrp1).

57 ng expression of melanogenic enzymes such as tyrosinase-related protein-1 (Tyrp1).

58 Tyrosinase (TYR), tyrosinase-related protein-1 (TYRP1/gp75) and dopachrome

59 9 targeting melanoma differentiation antigen tyrosinase-related protein-1 (Tyrp1; gp75) and active im

60 The MAAs studied included tyrosinase (Tyr), tyrosinase-related protein-1 and -2 (TRP-1 and TRP-2), g

61 00) had amino acid sequence homology to both tyrosinase-related protein-1 and -2.

62 o the M-box promoter elements of tyrosinase, tyrosinase-related protein-1 and dopachrome tautomerase/

63 MTS from the mouse brown locus product gp75/tyrosinase-related protein-1 and full-length OVA as a re

64 nd activity of Tyrosinase, and expression of Tyrosinase-related protein-1 and-2.

65 y the colocalization of TUNEL positivity and tyrosinase-related protein-1 immunoreactivity.

66 the skin of transgenic mice using either the Tyrosinase-Related Protein-1 or the keratin-14 (K14) pro

67 Tyrp1 gene expression and tyrosinase-related protein-1 production were also induce

68 e, melanoma antigen recognized by T cells-1, tyrosinase-related protein-1, and tyrosinase-related pro

69 dautochrome tautomerase, pMel 17/Silver and tyrosinase-related protein-1, but lack expression of the

70 er melanosomal proteins, such as tyrosinase, tyrosinase-related protein-1, dopachrome tautomerase, an

71 Immunity to the brown locus protein, gp75/ tyrosinase-related protein-1, was investigated in a syng

72 melanin-synthesizing enzymes tyrosinase and tyrosinase-related protein-1.

73 replicating mRNA) and the self/tumor antigen tyrosinase-related protein-1.

74 lanocyte differentiation antigens, including tyrosinase-related-protein-1 and gp100/pmel17, was marke

75 -eyed dilution and Pmel 17 (silver), but not tyrosinase-related protein 2 (slaty locus).

76 d have lost expression of the tyrosinase and tyrosinase-related protein 2 (TRP-2) antigens.

77 nses against the murine B16 melanoma using a tyrosinase-related protein 2 (TRP-2) peptide as a model

78 ify a normal tissue differentiation antigen, tyrosinase-related protein 2 (TRP-2), expressed by the m

79 261) express the melanoma antigens gp100 and tyrosinase-related protein 2 (TRP-2).

80 Immunization with hsp110- or grp170-tyrosinase-related protein 2 (TRP2(175-192)) peptide com

81 CD8+ T cells specific for the self/tumor Ag tyrosinase-related protein 2 (TRP2) are readily detected

82 DCs loaded with a peptide derived from tyrosinase-related protein 2 (TRP2) covalently linked to

83 T cells specific for the melanocyte antigen tyrosinase-related protein 2 (Trp2) in mice expressing o

84 Tyrosinase-related protein 2 (TRP2) is a melanosomal enz

85 arrying the lacZ reporter gene linked to the tyrosinase-related protein 2 (TRP2) promoter.

86 high-avidity T cells targeting the tumor Ag tyrosinase-related protein 2 (TRP2).

87 in both the tyrosinase-related protein 1 and tyrosinase-related protein 2 Ags in the context of the H

88 melanoma Ags MART-1, gp100, tyrosinase, and tyrosinase-related protein 2 as evaluated by specific cy

89 ous class I MHC-restricted B16 tumor peptide tyrosinase-related protein 2(180-188).

90 , TYRP1 (tyrosinase-related protein 1), DCT (tyrosinase-related protein 2), MART1 (melanoma antigens

91 ombined with a tumor-associated peptide from tyrosinase-related protein 2, our combined adjuvant appr

92 -boost vaccination with the melanoma antigen tyrosinase-related protein 2, which also showed a signif

93 toward targets loaded with a K(b)-restricted tyrosinase-related protein 2-derived peptide correlated

94 inst FAP and a tumor cell-expressed antigen, tyrosinase-related protein 2.

95 melanoma differentiation antigens gp100 and tyrosinase-related protein 2/dopachrome tautomerase and

96 ctors encoding the endogenous tumor Ags (TA) tyrosinase-related protein-2 (TRP-2) and glycoprotein 10

97 -associated Ags for the B16 murine melanoma: tyrosinase-related protein-2 (TRP-2) and the endogenous

98 ibody responses to a melanocyte autoantigen, tyrosinase-related protein-2 (TRP-2), as it is highly ex

99 -Dopachrome tautomerase (l-DCT), also called tyrosinase-related protein-2 (TRP-2), is a melanoma anti

100 transgene specific for the melanoma antigen tyrosinase-related protein-2 (TRP-2, Dct) harbor T cells

101 o an immunodominant CTL epitope derived from tyrosinase-related protein-2 administered with CpG-ODN a

102 Additionally, analysis of tyrosinase-related protein-2 and total melanin productio

103 related protein-1 and dopachrome tautomerase/tyrosinase-related protein-2 and transactivate these gen

104 f crest-derived cells that express c-kit and tyrosinase-related protein-2 characteristic of MPs.

105 ients (29%) expressed IgG antibody titers to tyrosinase-related protein-2 compared to four of 28 non-

106 SOX10 acts as a critical transactivator of tyrosinase-related protein-2 during melanoblast developm

107 DCs pulsed with KLH and mouse tyrosinase-related protein-2 peptide results in enhanced

108 combined with melanocyte differentiation Ag tyrosinase-related protein-2 peptide-based vaccination,

109 effect is most pronounced in a setting where tyrosinase-related protein-2 peptide-pulsed DCs alone ar

110 er these conditions corresponds to increased tyrosinase-related protein-2 production.

111 enes vaccine expressing the melanoma antigen tyrosinase-related protein-2 to protect mice against int

112 Tyrosinase-related protein-2 was found to exist in two d

113 Density-dependent expression of tyrosinase-related protein-2 was independent of time of

114 T cells-1, tyrosinase-related protein-1, and tyrosinase-related protein-2, respectively.

115 immunity against a murine melanoma self Ag, tyrosinase-related protein-2, using DCs transduced with

116 tomerase gene (Dct) and its protein product, tyrosinase-related protein-2, was studied in the culture

117 disrupting the intracellular trafficking of tyrosinase-related proteins and lysosome-associated memb

118 numbers of random mutations in two syngeneic tyrosinase-related proteins are used to immunize black m

119 oplasmic sequence, which is conserved in the tyrosinase related protein family and through vertebrate

120 tional levels that induces production of the tyrosinase-related proteins that have a significant role

121 Melanocyte differentiation Ags, including tyrosinase-related protein (TRP) 1, are relevant to both

122 st the melanocyte differentiation antigen, a tyrosinase-related protein (TRP) gp75(TRP-1) (the brown

123 Two T cell epitopes derived from tumor Ags, tyrosinase-related protein (TRP)-1 and TRP-2, were shown

124 me tautomerase, that the melanogenic protein tyrosinase-related protein (TRP)-1 can oxidize (HO)2IndC

125 we combined peptide vaccines with mAb to the tyrosinase-related protein (TRP)-1 surface Ag for the tr

126 open-reading frame sequences of tyrosinase, tyrosinase-related protein (TRP)-1, TRP-2, and melanoma-

127 recognize HLA-A2-restricted CTL epitopes in tyrosinase-related protein (TRP)-2 (clone MR7) and NY-ES

128 Tyrosinase-related protein (TRP)-2 is not only expressed

129 isoaspartic acid within the melanoma antigen tyrosinase-related protein (TRP)-2 peptide-(181-188) mak

130 ining the MHC class I-presented self-peptide tyrosinase-related protein (TRP)-2(180-188) and CpG-cont

131 88 of the melanocyte differentiation antigen tyrosinase-related protein (TRP)2.

132 ion antigens, gp100, MART-1, tyrosinase, and tyrosinase-related proteins (TRP) 1 and TRP-2, we observ

133 Tyrosinase and tyrosinase-related proteins (TRPs) are a family of melan