ライフサイエンスコーパス: tyrosine-phosphorylated protein

1 of a complex between c-Src and at least one tyrosine-phosphorylated protein.

2 lysaccharide (LPS) or IL-1 protein to bind a tyrosine-phosphorylated protein.

3 62(dok), RasGAP, and an unidentified 145-kDa tyrosine-phosphorylated protein.

4 mmunoprecipitate with an unidentified 87 kDa tyrosine-phosphorylated protein.

5 and could be easily modified to evaluate any tyrosine-phosphorylated protein.

6 converge, to similar cytoskeleton-dependent tyrosine phosphorylated proteins.

7 gressive motility, and alters the pattern of tyrosine phosphorylated proteins.

8 f PI-3K was associated with 100- and 180-kDa tyrosine phosphorylated proteins.

9 simultaneously via its SH2 domain with other tyrosine-phosphorylated proteins.

10 the ras related G protein rho A, as well as tyrosine-phosphorylated proteins.

11 reased Src kinase activity and PP2-sensitive tyrosine-phosphorylated proteins.

12 system was modified to identify partners of tyrosine-phosphorylated proteins.

13 point contacts containing enriched levels of tyrosine-phosphorylated proteins.

14 ted lipid rafts colocalized with the BCR and tyrosine-phosphorylated proteins.

15 mpetent to catalyze the dephosphorylation of tyrosine-phosphorylated proteins.

16 l contact components paxillin, vinculin, and tyrosine-phosphorylated proteins.

17 Cool-associated tyrosine-phosphorylated protein 1 (Cat-1) is a signaling

18 t; an association of PAK with 60- and 90-kDa tyrosine-phosphorylated proteins accompanied this.

19 Here, we report that multiple tyrosine-phosphorylated proteins accumulate transiently

20 , we found that CRKL rapidly associates with tyrosine-phosphorylated proteins after cross-linking of

21 Similarly, the 70-kDa tyrosine-phosphorylated protein also appears to represen

22 The newly tyrosine phosphorylated proteins and activated Src-famil

23 s talin and vinculin, have a central core of tyrosine phosphorylated proteins and are depleted of int

24 ombining mass spectrometry identification of tyrosine phosphorylated proteins and growth inhibition i

25 this site results in decreased affinity for tyrosine-phosphorylated proteins and decreased PI3K memb

26 man monocytes, M-CSF increased the levels of tyrosine-phosphorylated proteins and induced Akt activat

27 Clusters recruited tyrosine-phosphorylated proteins and induced spatially r

28 FR phosphorylation, decreased the numbers of tyrosine-phosphorylated proteins and levels of type I co

29 he stimulation of PI3-kinase associated with tyrosine-phosphorylated proteins and of p85/PI3-kinase a

30 recently that 14-3-3 associates with several tyrosine-phosphorylated proteins and phosphatidylinosito

31 Furthermore, tyrosine-phosphorylated proteins and PLC-gamma2 were col

32 ate may prove useful in the search for novel tyrosine-phosphorylated proteins and the identification

33 aralleled by morphological redistribution of tyrosine-phosphorylated proteins and the tyrosine kinase

34 y to bind to both substrates and appropriate tyrosine-phosphorylated proteins and therefore can compe

35 nding sites, an SH2 domain for binding other tyrosine phosphorylated proteins, and an enzymatic activ

36 CARP-1 is a tyrosine-phosphorylated protein, and ERRP treatments cau

37 qually applicable to serine-, threonine- and tyrosine-phosphorylated proteins, and is capable of sele

38 A high molecular mass tyrosine-phosphorylated protein (approximately 340 kDa)

39 Interactions between Dock and these tyrosine-phosphorylated proteins are likely mediated by

40 osphotyrosine and cortactin demonstrate that tyrosine-phosphorylated proteins, as well as cortactin,

41 Transmembrane accumulation of total tyrosine-phosphorylated proteins, as well as nonsynergis

42 ass spectrometric identification of a 155-kD tyrosine phosphorylated protein associated with src homo

43 ted with the Grb-2 adaptor and are the major tyrosine phosphorylated proteins associated with the Ras

44 demonstrated that SLP-76, a Grb2-associated tyrosine-phosphorylated protein, augments Interleukin-2

45 ory have shown that c-Cbl is the predominant tyrosine-phosphorylated protein bound to the p85 subunit

46 e binding (PTB) domain specifically binds to tyrosine-phosphorylated proteins, but differs in structu

47 Ganglioside G(M1), a lipid raft marker, and tyrosine-phosphorylated proteins, but not CD45 and trans

48 4-2 PCa cells showed a small set of discrete tyrosine-phosphorylated proteins, but these proteins wer

49 ir cell-surface antigen receptor overproduce tyrosine phosphorylated proteins; (c) lupus and lupus ne

50 lts in notable differences in the pattern of tyrosine phosphorylated proteins compared with that obta

51 ng tubular networks indicated differences in tyrosine phosphorylated proteins compared with the poorl

52 ably phosphorylated by Btk; however, a third tyrosine-phosphorylated protein coprecipitated with Brig

53 The tyrosine phosphorylated protein Crk-associated substrate

54 Analysis of tyrosine-phosphorylated proteins demonstrated that Crk-a

55 The availability of large pools of tyrosine-phosphorylated proteins derived from normal tis

56 The prominent tyrosine-phosphorylated proteins focal adhesion kinase,

57 Analysis of tyrosine-phosphorylated proteins following PTN stimulati

58 We have partially purified a 105-kDa tyrosine-phosphorylated protein from platelets stimulate

59 m of DEP-1 interacted with a small subset of tyrosine-phosphorylated proteins from lysates of the hum

60 nt study, we performed a global profiling of tyrosine-phosphorylated proteins from mutant Kit-driven

61 addition, DEP-1 coprecipitated with several tyrosine-phosphorylated proteins from pervanadate-treate

62 Three of the tyrosine-phosphorylated proteins have been identified as

63 ecipitations of Dock also co-precipitate two tyrosine-phosphorylated proteins having molecular masses

64 In contrast, only two tyrosine-phosphorylated proteins, i.e. insulin receptor

65 ith a co-precipitating high molecular weight tyrosine-phosphorylated protein identified as desmoglein

66 CRKL has previously been shown to be a major tyrosine phosphorylated protein in neutrophils of patien

67 -regulated kinase (ERK)-1 and ERK-2 as major tyrosine phosphorylated proteins in IL-1 stimulated chon

68 o acids in cell culture (SILAC), to identify tyrosine phosphorylated proteins in isogenic human bronc

69 on of disease correlated with a reduction of tyrosine phosphorylated proteins in lymph node cells of

70 synthesis, we analyzed the levels of nuclear tyrosine phosphorylated proteins in WT and Itgalpha1-nul

71 was shown to be the major CSF-1R-associated tyrosine-phosphorylated protein in CSF-1-treated BMM.

72 We initially identified a prominent 130-kDa tyrosine-phosphorylated protein in pervanadate-treated H

73 The GluN2B subunit is the major tyrosine-phosphorylated protein in synapses.

74 protein c-Cbl is one of the most prominently tyrosine-phosphorylated proteins in Bcr-Abl-expressing c

75 , R649A)-were prepared and used to pull down tyrosine-phosphorylated proteins in bovine ROS.

76 ling; however, current methods for analyzing tyrosine-phosphorylated proteins in crude protein extrac

77 tive Brk mutant (YF-Brk) and associates with tyrosine-phosphorylated proteins in deregulated signalin

78 identified by immunoaffinity purification of tyrosine-phosphorylated proteins in GIST cells before an

79 port that SHP-1 is associated with two major tyrosine-phosphorylated proteins in hematopoietic cells

80 e PTP, it preferentially targets a subset of tyrosine-phosphorylated proteins in host cells, includin

81 sk specifically associates with at least two tyrosine-phosphorylated proteins in normal human T cells

82 collagenase) markedly increase the number of tyrosine-phosphorylated proteins in platelets.

83 Shc PTB domain binds to 130 kDa and 145 kDa tyrosine-phosphorylated proteins in response to stimulat

84 Recruitment of GRB2 by tyrosine-phosphorylated proteins in response to TPO and

85 n intriguing set of serine-, threonine-, and tyrosine-phosphorylated proteins in the Archaea that may

86 Increased staining of tyrosine-phosphorylated proteins in the inner retina wer

87 mmunoaffinity profiling strategy to identify tyrosine-phosphorylated proteins in the KG-1 cell line.

88 within minutes in the appearance of numerous tyrosine-phosphorylated proteins in the liver and kidney

89 te results in the rapid accumulation of many tyrosine-phosphorylated proteins in the liver and kidney

90 differences in the profiles of 75- and 80-kD tyrosine-phosphorylated proteins in the zyxin-null cells

91 6 was found to coimmunoprecipitate with five tyrosine phosphorylated proteins including p60fyn and p5

92 co-distribute in all cell cortex extensions, tyrosine-phosphorylated proteins including p190 appear t

93 stream of GP Ib, and associates with several tyrosine-phosphorylated proteins including the Fc recept

94 ulated cells, SLAP-2 associated with several tyrosine phosphorylated proteins, including the ubiquiti

95 pectrometry that identifies large numbers of tyrosine-phosphorylated proteins, including active kinas

96 ects that involve up-regulated expression of tyrosine-phosphorylated proteins, including beta-catenin

97 Upon removal of the PTP inhibitor, the tyrosine-phosphorylated proteins, including Lck, Fyn, Sy

98 hat Btk formed stable complexes with several tyrosine-phosphorylated proteins, including PLCgamma2, o

99 fractions also contained discrete endogenous tyrosine-phosphorylated proteins, including prominent ba

100 ability of the Fyn SH2 domain to precipitate tyrosine-phosphorylated proteins, including the CD3zeta

101 TPIP1, or CD2-binding protein 1 (CD2BP1)], a tyrosine-phosphorylated protein involved in cytoskeletal

102 One of these tyrosine phosphorylated proteins is identified as p130Ca

103 on of the actin cup and local recruitment of tyrosine phosphorylated proteins is markedly attenuated.

104 ectron microscopy studies revealed that this tyrosine-phosphorylated protein is localized to the cyto

105 n of PI-3K and its association with specific tyrosine-phosphorylated proteins may be important in ins

106 Macrophage actin-associated tyrosine phosphorylated protein (MAYP) belongs to the Po

107 Termed macrophage actin-associated tyrosine-phosphorylated protein (MAYP), p37 is the major

108 hows that CD72 ligation induces a variety of tyrosine-phosphorylated proteins, most of which were of

109 There was no difference in the pattern of tyrosine-phosphorylated proteins observed following stim

110 d in ganglioside G(M1) and cholesterol where tyrosine phosphorylated proteins occur at late anaphase

111 A tyrosine phosphorylated protein of 100 kDa also coprecip

112 Furthermore, novel tyrosine phosphorylated proteins of approximately 60 kDa

113 name pp60(IRS3) to distinguish it from other tyrosine phosphorylated proteins of similar size.

114 Crk has been shown to bind to a tyrosine-phosphorylated protein of 116 kDa after TCR-med

115 nd SH3 domain of CMS bound specifically to a tyrosine-phosphorylated protein of 120 kDa, which we ide

116 is associated through its PTB domain with a tyrosine-phosphorylated protein of 140 kD (p140) in vivo

117 SH2) domain of Csk bound constitutively to a tyrosine-phosphorylated protein of 60 kDa (p60).

118 in the co-immunoprecipitation of MUC1 with a tyrosine-phosphorylated protein of approximately 180 kDa

119 In addition to p140, other tyrosine-phosphorylated proteins of 61 and 200 kD are co

120 ts implicate Shc, Grb2, p140, and additional tyrosine-phosphorylated proteins of 61 and 200 kD in sig

121 In rabbit colonic muscularis mucosae cells, tyrosine-phosphorylated proteins of approximately 60 and

122 Three tyrosine-phosphorylated proteins of MW 140, 79 and 69 k

123 I to explore the functions of these abundant tyrosine-phosphorylated proteins of synaptic vesicles.

124 Tyrosine-phosphorylated proteins on silver-stained gels

125 ar to that required to decrease the level of tyrosine phosphorylated proteins or of the protein tyros

126 Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes asso

127 NA cloning, and characterization of a 56-kDa tyrosine phosphorylated protein, p56(dok-2) (Dok-2), fro

128 A similar tyrosine-phosphorylated protein pattern was observed wit

129 Instead, a 100-kDa tyrosine-phosphorylated protein (pp100) co-immunoprecipi

130 ic Ab cross-linking, coprecipitates a 16-kDa tyrosine-phosphorylated protein (pp16).

131 SHPS-1 also associates with two tyrosine-phosphorylated proteins (pp55 and pp130) and a

132 h this increase is the appearance of several tyrosine phosphorylated proteins present only in differe

133 teins of both hck and fyn bound to a 150-kDa tyrosine-phosphorylated protein present in lysates of IL

134 p215BRCA1 was identified as a tyrosine phosphorylated protein primarily localized in t

135 [PtdIns(3,4,5)P3] and Src homology 2 domain [tyrosine-phosphorylated proteins, PtdIns(3,4,5)P3] of PL

136 It has been reported that tyrosine-phosphorylated proteins (PY) of host cells are

137 suggest a model in which association with a tyrosine-phosphorylated protein restricts the repertoire

138 Purification of the 190-kDa tyrosine-phosphorylated protein revealed that it consist

139 Analysis of tyrosine-phosphorylated proteins revealed that when 3T3

140 A tyrosine-phosphorylated protein(s) of approximately 42 k

141 The tyrosine-phosphorylated protein(s) regulates the convers

142 antibodies directed against known 60-70-kDa tyrosine-phosphorylated proteins suggest that pp68 may b

143 We have identified a high-molecular-mass tyrosine-phosphorylated protein that is rapidly phosphor

144 Because paxillin is a tyrosine-phosphorylated protein that may play a role in

145 n the chronic phase contain a constitutively tyrosine-phosphorylated protein that migrates at 62 kDa

146 The majority of the tyrosine-phosphorylated proteins that associate with PLC

147 In this study tyrosine-phosphorylated proteins that associate with PLC

148 The 130 kDa and 145 kDa tyrosine-phosphorylated proteins that associate with the

149 Comparison of the pattern of tyrosine-phosphorylated proteins that coprecipitate with

150 r tissue and forms a multimeric complex with tyrosine-phosphorylated proteins, that is, Shc.

151 We previously had found tyrosine phosphorylated protein to be heavily concentrat

152 nduces a subsequent, specific recruitment of tyrosine phosphorylated proteins to APP, including Lyn a

153 lamellipodial extension, and localization of tyrosine phosphorylated proteins to the cell periphery.

154 y, SAP specifically interacted with a 75-kDa tyrosine-phosphorylated protein upon TCR stimulation.

155 tivation, Shc also associates with a 145-kDa tyrosine-phosphorylated protein upon triggering via anti

156 ssembly of signaling complexes by binding to tyrosine phosphorylated proteins using their SH2 domains

157 small GTPase Ras, Nck is presumed to bind to tyrosine-phosphorylated proteins using its SH2 domain an

158 na was prepared for Western blot analysis of tyrosine-phosphorylated proteins, vascular endothelial g

159 One major tyrosine phosphorylated protein was identified as the TP

160 The 42-kDa tyrosine-phosphorylated protein was identified as Mck1,

161 n the course of this purification, a 105-kDa tyrosine-phosphorylated protein was only detected in fra

162 The increased intensity of these tyrosine-phosphorylated proteins was observed only in th

163 Cytochemistry for tyrosine-phosphorylated proteins was performed in myocyt

164 nti-phosphotyrosine antibodies to enrich for tyrosine phosphorylated proteins, we have identified a n

165 Subsequently, tyrosine phosphorylated proteins were immunopurified and

166 atients (<4 months), various sizes of highly tyrosine phosphorylated proteins were observed as high b

167 haracterize flow-activated tyrosine kinases, tyrosine-phosphorylated proteins were immunoprecipitated

168 Overall, tyrosine-phosphorylated proteins were increased after BV

169 Most of the tyrosine-phosphorylated proteins were Triton X-100-insol

170 that some of the selected sequences encoded tyrosine phosphorylated proteins when expressed on phage

171 ion of the EGFR was confirmed by analysis of tyrosine phosphorylated proteins, which revealed a rapid

172 and Sos1 inducibly associate with a 180-kDa tyrosine-phosphorylated protein, which was determined to

173 TPH1-D811A mutant trapped primarily a 97-kDa tyrosine-phosphorylated protein, which was determined to

174 omes associated with an approximately 72-kDa tyrosine-phosphorylated protein, which we identify here

175 Lyn B also showed increased binding of tyrosine-phosphorylated proteins, which included the neg

176 cked the assembly of F-actin, FAK, rho A and tyrosine-phosphorylated proteins while not affecting the

177 The SH2 domain of the Nck adaptor can bind tyrosine-phosphorylated proteins, while its SH3 domains

178 we report the identification of prominently tyrosine-phosphorylated proteins with a molecular mass o

179 We have previously identified a set of tyrosine-phosphorylated proteins with apparent molecular

180 tivation, and the association of a number of tyrosine-phosphorylated proteins with growth factor rece

181 We describe here two tyrosine-phosphorylated proteins with Mr values of 70,00

182 the adaptor molecule CBL, and association of tyrosine-phosphorylated proteins with phosphatidylinosit

183 terially expressed Shd domain bound multiple tyrosine-phosphorylated proteins with relative molecular

184 accompanied by an increase in association of tyrosine-phosphorylated proteins with the adapter protei

185 Synaptogyrins comprise a family of tyrosine-phosphorylated proteins with two neuronal (syna

186 We found increased intensity of two tyrosine-phosphorylated proteins, with relative mobiliti