ライフサイエンスコーパス: ubiquitin

1 nt interactions with the nucleosome and with ubiquitin.

2 ins, the UBL domain is atypical, as it binds ubiquitin.

3 ted by interactions with membrane lipids and ubiquitin.

4 ytic activities through its interaction with ubiquitin.

5 suppressor p53, alpha-synuclein, and folded ubiquitin.

6 1)/CXCL12(2) were higher than the potency of ubiquitin.

7 leaves polyubiquitin chains of three or more ubiquitins.

8 K63 ubiquitin, a type of ubiquitin chain that functions inde

9 expression of the anti-inflammatory molecule ubiquitin A20 and significant inhibition of the activati

10 Removal of ubiquitin acceptor residues from the somatostatin recept

11 Together these findings show that the ubiquitin-activated interaction trap (UBAIT) fusion syst

12 is was reduced by inhibition or depletion of ubiquitin-activating enzymes.

13 Pd(II) was applied for the synthesis of two ubiquitin activity-based probes (Ub-ABPs) employing soli

14 of nonalcoholic steatohepatitis, keratin and ubiquitin aggregates within cytoplasmic Mallory-Denk bod

15 phosphonothiolate-linked diubiquitin and an ubiquitin-alpha-synuclein conjugate.

16 iate through co-immunopurification and split-ubiquitin analyses, and uncovered that they form tripart

17 es bridging contacts between the nucleosome, ubiquitin and COMPASS.

18 Fueled by the identification of novel ubiquitin and UBL sites and the characterization of the

19 Natural CXCR4 agonists (CXCL12, ubiquitin) and engineered CXCL12 variants (CXCL12(1), CX

20 adhering beta-cyclodextrin to the surface of ubiquitin, and (iii) selective detection of (19)F-(19)F

21 by etoposide were shown to be conjugated to ubiquitin, and this was reduced by inhibition or depleti

22 They also uncover that this interaction with ubiquitin, and thus with modified substrates, can be mod

23 tions (blebs) containing FG-nucleoporins and ubiquitin are the phenotypic hallmark of Torsin ATPase m

24 5.5 nm radius) culminated in IEM ejection of ubiquitin, as long as the protein carried a sufficiently

25 The linear ubiquitin assembly complex (LUBAC) is an essential compo

26 tidomain enzymes, they contain an N-terminal ubiquitin-association domain, a central Src homology 3 d

27 Phosphorylation of ubiquitin at Thr12 in the chromatin context is a new his

28 priming) followed by repetitive ubiquitin-to-ubiquitin attachment (elongation).

29 Thus, ubiquitin binding by the Ig3 domain promotes MALT1 activ

30 ibition by blocking a catalytically critical ubiquitin binding site.

31 Interfering with DupA-ubiquitin binding switches its activity toward SidE-type

32 ingle mutants, or a COPI mutant deficient in ubiquitin binding, display a defect in recycling FM4-64

33 d identified residues that are important for ubiquitin binding.

34 e and that hydroxylation of Asn(35) inhibits ubiquitin binding.

35 In addition to ubiquitin-binding and ubiquitin-like domains, they conta

36 ain specificity and the third binds a unique ubiquitin-binding domain (UBD).

37 vitro, establishing UBA(Cez) as a functional ubiquitin-binding domain.

38 raction (not in the chromatin); requires the ubiquitin-binding domains (UBA1/2) of USP13; and occurs

39 mutation in TYMV PRO/DUB aimed at improving ubiquitin-binding led to a much more active DUB.

40 stead reroutes MHC-I to lysosomes, using the ubiquitin-binding receptor NBR1, precluding T cell recog

41 Markers of neuronal injury (Ubiquitin Carboxy-terminal Hydrolase L1 [UCH-L1]), micro

42 The mechanisms of ubiquitin chain formation remain unclear and include a s

43 otential coordination between these steps in ubiquitin chain formation remains undefined.

44 K63 ubiquitin, a type of ubiquitin chain that functions independently of the prot

45 role as regulatory domain by binding various ubiquitin chain types.

46 Here, using synthetic and enzyme-derived ubiquitin chains along with intact mass spectrometry, we

47 ive DNA structure, whereupon long K48-linked ubiquitin chains are conjugated to CMG-Mcm7, dependent o

48 uss recent advances on these nonconventional ubiquitin chains in neural development, function, plasti

49 (11)-, Lys(48)-, Lys(63)-, and Met(1)-linked ubiquitin chains in vitro, establishing UBA(Cez) as a fu

50 Protein modification with poly-ubiquitin chains is a crucial process involved in a myri

51 Poly-ubiquitin chains of >= Ub3 stimulate TDP2 catalytic acti

52 ysiological functions of Lys-63 (K63)-linked ubiquitin chains, although they are the second most abun

53 2020 identify members of a membrane-tethered ubiquitin complex that attenuates Hedgehog signaling str

54 We identified Ube2v1 (ubiquitin-conjugating enzyme E2 variant 1) in a genome-w

55 fector MavC induces ubiquitination of the E2 ubiquitin-conjugating enzyme UBE2N by transglutamination

56 urrent understanding of interactions between ubiquitin conjugation and deconjugation machineries and

57 s, raising cGMP also enhanced within minutes ubiquitin conjugation to cell proteins.

58 fers to the use of small molecules to induce ubiquitin-dependent degradation of proteins.

59 ression of 19S RP subunits, which facilitate ubiquitin-dependent degradation, were decreased in the c

60 olled by IRT1 non-iron metal substrates in a ubiquitin-dependent manner.

61 theme is that viperin appears to facilitate ubiquitin-dependent proteasomal degradation of some of t

62 es in response to inflammation, triggers the ubiquitin-dependent proteasomal degradation of the cytoc

63 h stabilizes RUNX2 by diverting it away from ubiquitin-dependent proteasomal degradation.

64 he tumor suppressor LATS exhibiting enhanced ubiquitin-dependent proteasomal degradation.

65 In contrast to peptide P1, UV-irradiation of ubiquitin did not induce H/D scrambling in the nonfragme

66 Together, these data suggest that DDI2 is a ubiquitin-directed endoprotease.

67 A construct combining the RING domain of ubiquitin E3 ligase RNF4 with a protein-specific camelid

68 roup D2 protein (FANCD2) by the multisubunit ubiquitin E3 ligase, the FA core complex, is an obligate

69 subsequently phospho-inactivates Nedd4-2, an ubiquitin E3 ligase.

70 We screened an RNAi library targeting ubiquitin E3 ligases and observed that knockdown of the

71 r processes employ protein ubiquitylation by ubiquitin E3 ligases for functional regulation or protei

72 etion or depletion of the N-end rule pathway ubiquitin E3 ligases in NatB mutants did not restore NAD

73 otein of interest (POI) and another to an E3 ubiquitin (E3) ligase, connected via a linker.

74 d substrates, which allows DupA to cleave PR ubiquitin from substrates.

75 The diversity of ubiquitin functions in the cell is partly due to its abi

76 jor and the secondary recognition patches of ubiquitin (Ile(44) patch and Ile(36) patch, respectively

77 We find that PRO/DUB recognizes ubiquitin in an unorthodox way: It interacts with the bo

78 h they are the second most abundant forms of ubiquitin in plant cells.

79 liently controlled by polyglutamine-adjacent ubiquitin-interacting motifs (UIMs) that enhance aggrega

80 Although Ddi1 contains both ubiquitin-interacting UBA and proteasome-interacting UBL

81 reveal that the interaction of UBA(Cez) with ubiquitin is mediated via a noncanonical surface and tha

82 Moreover, proteasome-associated ubiquitin is reduced following E6AP knockdown or displac

83 e ubiquitination events and demonstrate that ubiquitin is transferred to substrate from the closed co

84 Ubiquitin-labeled vacuoles containing L. pneumophila fai

85 We identified a cullin-RING ubiquitin ligase (CRL), containing the substrate adaptor

86 fects of the SUMO-SIM interaction on ICP0 E3 ubiquitin ligase activity regarding PML II degradation.

87 recruit PRC1 from extracts and enhance PRC1 ubiquitin ligase activity towards histone H2A.

88 TRAF6 E3 ubiquitin ligase activity was required for the former bu

89 e to a balance between the actions of the E3 ubiquitin ligase anaphase-promoting complex or cyclosome

90 MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial mem

91 In summary, UBR5 is a novel MYC ubiquitin ligase and an endogenous rheostat for MYC acti

92 d Pseudomonas effector AvrPtoB acts as an E3 ubiquitin ligase and promotes bacterial virulence.

93 to proteasomal degradation of mTOR by the E3 ubiquitin ligase c-Cbl.

94 The ubiquitin ligase CHIP (C terminus of HSC70-interacting p

95 ing out competitive binding to A3G or the E3 ubiquitin ligase complex as the sole mechanism.

96 in the Kelch-like 3-Cullin 3 (KLHL3-CUL3) E3 ubiquitin ligase complex have shed light on the importan

97 AI2), triggering its association with the E3 ubiquitin ligase complex SCF(MAX2) and downstream target

98 and E4orf6, that together co-opt a cellular ubiquitin ligase complex to overcome host defences and p

99 molecular feedback loop via the COP1/SPA E3 ubiquitin ligase complex, suggesting a mechanism that ma

100 regulator 1), an adaptor for CUL3 (CULLIN3) ubiquitin ligase complex.

101 ine hydroxylase (PHD, alias EGLN), and an E3 ubiquitin ligase component for HIF destruction called vo

102 ed alone, or together with other cullin-ring ubiquitin ligase components, which comprise a greatly ex

103 complex, or cyclosome (APC/C), is a large E3 ubiquitin ligase composed of 14 subunits.

104 lia is regulated post-translationally by the ubiquitin ligase COP1 (also called RFWD2).

105 new identified interaction partner is the E3 ubiquitin ligase cullin 3, which was revealed to regulat

106 Here, we report that the E3 ubiquitin ligase Cullin 5/RBX2 (CRL5) controls the stabi

107 rs ERG recognition and degradation by the E3 ubiquitin ligase FBW7 in a manner independent of a canon

108 lly, we find that loss of the Elf5-regulated ubiquitin ligase FBXW7 ensures stabilization of its puta

109 result of its reduced degradation by the E3 ubiquitin ligase FBXW7.

110 quitin protein ligase 1 (MIB1) as a novel E3 ubiquitin ligase for WRN protein.

111 We determine that the Siah2 E3 ubiquitin ligase functions in a coincidence detection ci

112 o TQC enzymes, the ER-associated degradation ubiquitin ligase Hrd1 and zinc metalloprotease Ste24, pr

113 The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) s

114 In VZV-infected skin, kallikrein 6 and the ubiquitin ligase MDM2 are upregulated concomitant with k

115 ort a novel regulatory mechanism: another E3 ubiquitin ligase Mdm2 directly binds parkin and enhances

116 findings suggest a model in which the ZSWIM8 ubiquitin ligase mediates TDMD by directing proteasomal

117 Avadomide, a CRL4CRBN E3 ubiquitin ligase modulator, demonstrated clinical activi

118 the global chromatin response, we tested the ubiquitin ligase mutant uls1Delta, which selectively imp

119 se models, we further discovered that the E3 ubiquitin ligase Nedd4 is required for developmental mye

120 USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which mediates the degradation

121 Infected cell protein 0 (ICP0), an E3 ubiquitin ligase of herpes simplex virus 1 (HSV-1), can

122 nscriptional activity and suggest that an E3 ubiquitin ligase other than FBXO25 regulates ELK-1 ubiqu

123 o clear damaged mitochondria involves the E3 ubiquitin ligase Parkin and PTEN-induced kinase 1 (PINK1

124 Loss-of-function mutations in the E3 ubiquitin ligase parkin have been implicated in the deat

125 The E3 ubiquitin ligase Parkin promotes the degradation of dama

126 n with the Parkinson's disease-associated E3 ubiquitin ligase Parkin.

127 Here, we identified the E3 ubiquitin ligase Peli1 as an important regulator of T ce

128 ARIH2 encodes TRIAD1, an E3 ubiquitin ligase required for termination of emergency g

129 mbrane-associated RING-CH 8 (MARCH8), the E3 ubiquitin ligase responsible for MHC II ubiquitination s

130 TRIM14, a noncanonical TRIM that lacks an E3 ubiquitin ligase RING domain, is a critical negative reg

131 We found that eas-1 inhibits a conserved E3 ubiquitin ligase rnf-145/RNF145, which, in turn, promote

132 by an ER membrane complex consisting of the ubiquitin ligase RNF185, the ubiquitin-like domain conta

133 y stabilizing key melanoma oncoproteins, the ubiquitin ligase RNF4 promotes tumorigenesis and confers

134 we show that this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediat

135 ltiple replisome components that bind to the ubiquitin ligase SCF(Dia2).

136 te ubiquitination by a member of the largest ubiquitin ligase subtype and reveal how a defined archit

137 standing of TRAIP, a replisome-associated E3 ubiquitin ligase that is mutated in microcephalic primor

138 RLIM is an E3 ubiquitin ligase that leads to the ubiquitination and de

139 RNF128 is an E3 ubiquitin ligase that targets p53 for degradation.

140 Von Hippel-Lindau (VHL) is an E3 ubiquitin ligase that targets proteins, including HIF-1a

141 ACT1 leading to the release of the essential ubiquitin ligase TRAF6 from the complex.

142 The E3 ubiquitin ligase TRIM21 plays a crucial role as a negati

143 mediated by the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21.

144 ibition depends on levels of the centrosomal ubiquitin ligase TRIM37.

145 fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing prot

146 This complex cooperates with cytosolic ubiquitin ligase UBE3C and p97 ATPase in degrading their

147 idase, arginyltransferase, and the double-E3 ubiquitin ligase UBR1-RAD6/UFD4-UBC4/5 are shown to form

148 gh the activity of the E7-associated host E3 ubiquitin ligase UBR4.

149 N14 and targets it for degradation using the ubiquitin ligase UBR4.

150 Here, we show how ubiquitin ligase UBR5 functions as a molecular rheostat

151 s a poorly characterized RNA-binding RING E3-ubiquitin ligase with functions in embryonic development

152 The UBE3A gene encodes an E3 ubiquitin ligase with three known protein isoforms in hu

153 cells, we show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppressing transmembr

154 how that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt sign

155 , we identified a P3-inducible U-box type E3 ubiquitin ligase, designated as P3-inducible protein 1 (

156 Parkin is an E3 ubiquitin ligase, functioning in mitophagy.

157 La cell extracts and identify this as the E3 ubiquitin ligase, HECTD1.

158 otein interactions that, in the context of a ubiquitin ligase, lead to protein degradation(1).

159 g to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradatio

160 RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by

161 somes, RAB7 directly interacts with TRAF6 E3 ubiquitin ligase, which catalyzes K63 polyubiquitination

162 that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and prot

163 Our study also identified an E3 ubiquitin ligase, which targets the RdDM compotent NRPD1

164 We propose that the PM-anchored Rsp5/Rcr1 ubiquitin ligase-adaptor complex can provide an acute re

165 duced membrane-associated ring CH (MARCH) E3 ubiquitin ligase-mediated ubiquitination and downregulat

166 bxo45, two components of an intracellular E3 ubiquitin ligase.

167 PCF11, by the cancer-specific MAGE-A11-HUWE1 ubiquitin ligase.

168 autoubiquitination and degradation of an E3 ubiquitin ligase.

169 rgets of PfPP1 for egress: a HECT E3 protein-ubiquitin ligase; and GCalpha, a fusion protein composed

170 Ubiquitin ligases (E3s) embedded in the endoplasmic reti

171 iving substrate ubiquitination together with ubiquitin ligases (E3s), many E2s can also autoubiquitin

172 rtant insights into the large family of MAGE ubiquitin ligases and identify approaches for developing

173 lar bridge, where they recruit CUL4 and MDM2 ubiquitin ligases and the proteasome.

174 molecular level, many MAGEs bind to E3 RING ubiquitin ligases and, thus, regulate their substrate sp

175 antagonistic roles of two closely related E3 ubiquitin ligases are required for netrin-1-dependent fi

176 The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B m

177 substrate adaptor for cullin3-containing E3 ubiquitin ligases, and KLHL15 gene mutations were recent

178 However, unlike SidE ubiquitin ligases, DupA displays increased affinity to P

179 omplished by the coordination of multiple E3 ubiquitin ligases, including Rsp5, the Dsc complex, and

180 a subunit of E3 Skp1/Cullin-1/F-box protein ubiquitin ligases, is modified by a prolyl hydroxylase t

181 ngle-protein and multicomponent RING-type E3 ubiquitin ligases.

182 h act as substrate adaptors of CUL3-based E3 ubiquitin ligases.

183 pecificity of ubiquitination is conferred by ubiquitin ligases.

184 ing ubiquitination and three antagonistic E3 ubiquitin ligases: Grr1 and Ptr1 maintained basal Sir2 l

185 t and ligase activity but requires an intact ubiquitin-like (UBL) domain.

186 we identified an NF-kB-binding site in USP7, ubiquitin-like domain 2, that selectively mediates inter

187 nsisting of the ubiquitin ligase RNF185, the ubiquitin-like domain containing proteins TMUB1/2 and TM

188 In addition to ubiquitin-binding and ubiquitin-like domains, they contain a conserved region

189 Small ubiquitin-like modifier (SUMO1-3) conjugation (SUMOylati

190 AIPL1 interacts with the cytokine-inducible ubiquitin-like modifier FAT10, which gets covalently con

191 We found that SUMO (Small Ubiquitin-like Modifier) and SUMO ligase Ubc9 are requir

192 Interactions of CaWss1 with Cdc48 and small ubiquitin-like modifier, although not strictly required,

193 ISG15 is a ubiquitin-like molecule that can be conjugated to protei

194 These findings explain how a distinctive ubiquitin-like protein alters the functions of its targe

195 of neddylation, the conjugation of the small ubiquitin-like protein NEDD8 to lysine residues, interru

196 Here, we show that in Drosophila the small ubiquitin-like protein SUMO and the SUMO E3 ligase Su(va

197 e seminal findings of Ohsumi was on the role ubiquitin-like proteins (UBLs)-Atg5, Atg12, and Atg8-pla

198 1-like DUB prefers ubiquitin substrates over ubiquitin-like proteins and efficiently cleaves polyubiq

199 we demonstrate that the epigenetic regulator ubiquitin-like with plant homeodomain and RING finger do

200 Ubiquitin mediated signaling contributes critically to h

201 7) interacts with HsSAS-6 and targets it for ubiquitin-mediated degradation.

202 lates the WEE1 protein and rescues WEE1 from ubiquitin-mediated degradation.

203 y E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediated mechanism for regulation of Clec9A, r

204 geting effect, suggesting the involvement of ubiquitin-mediated proteasomal degradation in the proces

205 The ubiquitin-mediated proteasomal pathway regulates diverse

206 a heat shock cognate (HSC70) clients using a ubiquitin-mediated proximity tagging strategy and show t

207 We demonstrate that an engineered N-terminal ubiquitin modification changes the aggregation process o

208 The ubiquitin modification targets 4 lysine residues on Zta,

209 wing discrimination of endogenous NEDD8- and ubiquitin-modification sites by MS after Lys-C digestion

210 can target soluble oligomers assembled from ubiquitin-modified proteins independently of its peptida

211 iquitination of the ID complex, in which one ubiquitin molecule is conjugated to each of FANCI and FA

212 e open, trough-like ID structure through the ubiquitin of one protomer binding to the other protomer

213 pans the face of the nucleosome, recognizing ubiquitin on one face of the nucleosome and methylating

214 ) domain with ubiquitin revealed three bound ubiquitins: one engages the S1 site, the second binds an

215 le myeloma and B-cell lymphomas has made the ubiquitin pathway an important emerging therapeutic targ

216 Upon CCCP treatment, but not 991, ubiquitin phosphorylation, a read-out of PTEN-induced ki

217 of FTD/ALS, as well as huntingtin-positive, ubiquitin-positive aggregates in the frontal cortex.

218 uires two steps: substrate modification with ubiquitin (priming) followed by repetitive ubiquitin-to-

219 ells using the new photocaged cell-permeable ubiquitin probe and identified DUBs captured by the prob

220 Importantly, the photocaged cell-permeable ubiquitin probe captured DUBs specifically in respective

221 re we report a new photocaged cell-permeable ubiquitin probe that undergoes photoactivation upon 365

222 Though ubiquitin proteases play a key role in this process by c

223 emains unknown, though altered expression of ubiquitin proteasome system (UPS) components have implic

224 es, a substrate recognition component of the ubiquitin proteasome system (UPS), have an integral role

225 ing the autophagy-lysosomal pathway when the ubiquitin proteasome system is compromised, thus contrib

226 Ube2v1 knockdown improved ubiquitin proteasome system performance and promoted the

227 induced aggregate formation through enhanced ubiquitin proteasome system performance rather than auto

228 osylation causes the inhibition of a nuclear ubiquitin proteasome system responsible for SRF stabiliz

229 nanobody mediates target destruction by the ubiquitin proteasome system, a process we describe as an

230 lity-dependent HIF-alpha degradation via the ubiquitin proteasome system.

231 protein clearance (associated with deficient ubiquitin-proteasome and autophagy-lysosomal systems), n

232 opic E3 whose abundance is auto-regulated by ubiquitin-proteasome dependent degradation.

233 een shown to be rapidly degraded through the ubiquitin-proteasome pathway in response to cholesterol

234 elated Modifier) pathway crosstalks with the ubiquitin-proteasome pathway to affect TOC159 stability

235 During protein degradation by the ubiquitin-proteasome pathway, latent 26S proteasomes in

236 KRT10, targeting it for degradation via the ubiquitin-proteasome pathway.

237 drugs bortezomib and carfilzomib target the ubiquitin-proteasome pathway.

238 ubiquitination and degradation of WRN in the ubiquitin-proteasome pathway.

239 The ubiquitin-proteasome system (UPS) is an important post-t

240 The ubiquitin-proteasome system (UPS) is involved in most ce

241 mRNA export, it remains unknown whether such ubiquitin-proteasome system (UPS) regulation of Sub2 occ

242 uitination and degradation of the POI by the ubiquitin-proteasome system (UPS).

243 which greatly increase substrate load on the ubiquitin-proteasome system and eventually activate the

244 regulate ribosome abundance through both the ubiquitin-proteasome system and forms of autophagy refer

245 The ubiquitin-proteasome system facilitates the degradation

246 The ubiquitin-proteasome system is the canonical pathway for

247 radation pathways, such as autophagy and the ubiquitin-proteasome system, is associated with various

248 rotein quality control pathways, such as the ubiquitin-proteasome system, mitochondria per se can inf

249 ells, proteome remodeling is mediated by the ubiquitin-proteasome system, which regulates protein deg

250 show that these proteins are degraded by the ubiquitin-proteasome system.

251 m35-2HA(ts) are degraded from the MOM by the ubiquitin-proteasome system.

252 Moreover, while CB(1)-iLTD increased ubiquitin/proteasome activity, ubiquitination but not pr

253 the role played by CSA and CSB as part of a ubiquitin/proteasome degradation process involved in tra

254 downstream increase of target-HECT domain E3 ubiquitin protein ligase 1 (HECTD1) expression, an incre

255 Here, we identify mindbomb E3 ubiquitin protein ligase 1 (MIB1) as a novel E3 ubiquiti

256 und heterozygous deleterious variants in the Ubiquitin protein ligase E3 component N-recognin 5 (UBR5

257 Using ubiquitin proteomics, we found that ubiquitination profi

258 for TNI/UBP14 in the auxin response through ubiquitin recycling.

259 e states of translation, suggesting that K63 ubiquitin regulates protein synthesis at a selective sta

260 med high-throughput CRISPR screening using a ubiquitin regulator-focused single-guide RNA library in

261 Variants in ubiquitin-related genes, previously implicated in autoin

262 nhibitor of activated STAT (PIAS) 1, a small ubiquitin-related modifier E3 ligase that facilitates C/

263 We demonstrate that the SUMO (Small Ubiquitin-related Modifier) pathway crosstalks with the

264 s of ribosomes from mutant cells lacking K63 ubiquitin resolved at 4.4-2.7 angstrom showed 80S riboso

265 tal structure of the DUB (OtDUB) domain with ubiquitin revealed three bound ubiquitins: one engages t

266 Mating-based split-ubiquitin screens and in vivo Forster resonance energy t

267 USP14 antagonized RNF168-dependent ubiquitin signaling and downstream 53BP1 chromatin recru

268 RNF168 protein expression and ubiquitin signaling are finely regulated during the sens

269 eadth of chromatin functions associated with ubiquitin signaling is emerging.

270 nctional diversification of SRPK to regulate ubiquitin signaling that ensures correct regulation of n

271 family of deubiquitinases regulates diverse ubiquitin signals in humans.

272 By removing host ubiquitin signals, for example, invading pathogens can i

273 noubiquitin from the ELK-1 ETS domain by the Ubiquitin Specific Protease USP17 was shown to augment E

274 e feedback loop, mediated by upregulation of ubiquitin-specific peptidase 18 (USP18).

275 al modulators of Foxp3 expression, including ubiquitin-specific peptidase 22 (Usp22) and ring finger

276 Conversely, USP7 (deubiquitinase ubiquitin-specific peptidase 7) opposes the activities o

277 ng the deubiquitinase herpesvirus-associated ubiquitin-specific protease (HAUSP), which stabilizes RU

278 daptor molecule-binding protein (STAMBP) and ubiquitin-specific protease 33 (USP33) as cognate deubiq

279 IRFs 1, 3, and 4 are known to interact with ubiquitin-specific protease 7 (USP7); interactions of vI

280 TMEM79 interacts with ubiquitin-specific protease 8 (USP8), whose activating m

281 Here, we report the identification of a ubiquitin-specific protease, USP7, as a regulatory switc

282 Here, we show that mutation in TARANI/UBIQUITIN-SPECIFIC PROTEASE14 (TNI/UBP14) leads to reduc

283 We developed serial NEDD8-ubiquitin substrate profiling (sNUSP), a method that emp

284 The Ulp1-like DUB prefers ubiquitin substrates over ubiquitin-like proteins and ef

285 Specifically, we review how the ubiquitin system affects expression of genes or abundanc

286 by the ubiquitin system, and discuss how the ubiquitin system affects proteins involved in pathogen o

287 This review presents information on the ubiquitin system and regulation of NF-kappaB by ubiquiti

288 The ubiquitin system regulates the DNA damage response (DDR)

289 studies on how seed size is affected by the ubiquitin system, and discuss how the ubiquitin system a

290 DNA replication is highly regulated by the ubiquitin system, which plays key roles upon stress.

291 This mechanism pushes CMG beyond a '5-ubiquitin threshold' that is inherent to Cdc48, which sp

292 northodox way: It interacts with the body of ubiquitin through a split recognition motif engaging bot

293 Binding of Ubiquitin to the H(abc) domain may regulate the function

294 h ubiquitin (priming) followed by repetitive ubiquitin-to-ubiquitin attachment (elongation).

295 ~Ub represents the active form that mediates ubiquitin transfer has yet to be experimentally tested.

296 otif, which mediates interaction with the E3 ubiquitin (Ub) ligase Nedd4-2.

297 riazole-based deubiquitylase (DUB)-resistant ubiquitin (Ub) probes have recently emerged as effective

298 phytohormone signaling pathways rely on the ubiquitin (Ub) proteasome system, specifically E3 Ub lig

299 demonstrate that either the structure of the ubiquitin-ubiquitin junction or its dynamic assembly or

300 Ubiquitin was chosen as the model protein because of its