ライフサイエンスコーパス: ubiquitin C

1 ated gene products were identified including ubiquitin C.

2 Gene expression of ubiquitin C and proteasome subunits C2, C3, and C9 was n

3 evealed transcriptional alterations of Creb, ubiquitin-C, and other housekeeping genes in PS-deficien

4 In addition, we found that EGR1, eEF1a, and ubiquitin C are up-regulated by Ant1 overloading.

5 AKT, ubiquitin C, ERK1/2 and NF-kappaB occupied dominant node

6 ays provide evidence that PPARbeta regulates ubiquitin C expression, and that ubiquitination of prote

7 is, and this is due in part to regulation of ubiquitin C expression.

8 -term transcriptional silencing of the human ubiquitin C gene (UbC).

9 the assertion that the homogenization of the ubiquitin-C gene in rodents is due to unequal crossing-o

10 This study highlights the value of ubiquitin C/green fluorescent protein (UBC-GFP) transgen

11 s 40 promoter, and three cellular promoters: ubiquitin C, mPGK, and hEF-1a.

12 The human ubiquitin C promoter (UBC)-driven-GFP transgenic mouse i

13 ssing transgenic mice by inserting the human ubiquitin C promoter coupled to the firefly luciferase r

14 By contrast, adenoviruses containing the ubiquitin C promoter failed to elicit these effects.

15 ouse transgenic line was generated using the ubiquitin C promoter to drive inducible expression of La

16 FP with the EF1 alpha promoter, pUB-GFP with Ubiquitin C promoter, and pEYFP-Mitotrap with CMV promot

17 nic fibroblasts, adenoviruses containing the ubiquitin C promoter, but not the cytomegalovirus immedi

18 ovirus immediate-early promoter, but not the ubiquitin C promoter, cooperated with chemotherapeutic a

19 2 and a cre/ERT2 transgene controlled by the ubiquitin C promoter.

20 ed human CLN3 under the control of the human ubiquitin C promoter.

21 virus encoded the GFP regulated by the human ubiquitin-C promoter, which is active in a wide variety

22 However, the ubiquitin-C promoter-mediated transcription is also redu

23 biquitinating enzymes based on the substrate ubiquitin C-terminal 7-amido-4-methylcoumarin (Ub-AMC).

24 as determined to be competition with Ub-AMC (ubiquitin C-terminal 7-amido-4-methylcoumarin).

25 (2) The kinetics of inhibition of UCH-L3 by ubiquitin C-terminal aldehyde (Ub-H) were determined and

26 omal protein synthesized as an 80-amino acid ubiquitin C-terminal extension protein (CEP80), function

27 allenge, we developed novel chemical probes, ubiquitin C-terminal fluorescein thioesters UbMES and Ub

28 ecies contain modified peptides in which the ubiquitin C-terminal Gly-Gly residues are retained on th

29 lement-binding protein 1 (CREB1), CREB2, and ubiquitin C-terminal hydrolase (Ap-uch) have been implic

30 and the regulation of one of its components, ubiquitin C-terminal hydrolase (ap-uch), in LTD.

31 PGP9.5 (UCH-L1) is a member of the ubiquitin C-terminal hydrolase (UCH) family of proteins

32 e approach to tag active DUBs, we identified ubiquitin C-terminal hydrolase (UCH) isoform L3 as the p

33 The neuronal ubiquitin C-terminal hydrolase (UCH) UCH-L1 has been lin

34 esent study measured serum concentrations of ubiquitin C-terminal hydrolase (UCH-L1) and glial fibril

35 Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-terminal hydrolase (UCH-L1) have been FDA-ap

36 f glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase (UCH-L1) levels became th

37 Ubiquitin C-terminal hydrolase (UCH-L1), also called neu

38 e crystal structure of the recombinant human Ubiquitin C-terminal Hydrolase (UCH-L3) by X-ray crystal

39 Ubiquitin C-terminal hydrolase 37 (UCH37 also known as U

40 point blockade (ICB) response, including the ubiquitin C-terminal hydrolase 5 (UCHL5).

41 The deubiquitylating enzyme ubiquitin C-terminal hydrolase 6 [Ubp6; ubiquitin-specif

42 form a protein complex with the unidentified ubiquitin C-terminal hydrolase and recruit UbC1 to this

43 smodium falciparum homologue, members of the ubiquitin C-terminal hydrolase family, use a unique acti

44 was immunoprecipitated with NUB1 served as a ubiquitin C-terminal hydrolase for UbC1.

45 the unfolded state of the 52-knotted protein ubiquitin C-terminal hydrolase isoenzyme L1 (UCH-L1) and

46 f glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) as day-of-inj

47 Glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase L1 (UCH-L1) have been wid

48 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

49 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is a deubiqui

50 ifunctional molecule of the ubiquitin system ubiquitin C-terminal hydrolase L1 (UCH-L1) is induced in

51 Ubiquitin C-terminal hydrolase L1 (UCH-L1) is one of the

52 Ubiquitin C-terminal hydrolase L1 (UCH-L1), a blood-base

53 key mechanism mediating the deficit involves ubiquitin C-terminal hydrolase L1 (UCH-L1), a deubiquiti

54 h harbor a deletion within the gene encoding ubiquitin C-terminal hydrolase L1 (Uch-L1), display sens

55 We now show that a component of the pathway, ubiquitin C-terminal hydrolase L1 (Uch-L1), is required

56 A mutant of ubiquitin C-terminal hydrolase L1 (UCHL1) detected in ea

57 cantly increase the levels of Abeta, Tau and Ubiquitin C-Terminal Hydrolase L1 (UCHL1) in mouse cereb

58 Ubiquitin C-terminal hydrolase L1 (UCHL1) is a unique br

59 al fibrillary acidic protein (GFAP), tau and ubiquitin c-terminal hydrolase L1 (UCHL1) were assessed

60 Ubiquitin C-terminal hydrolase L1 (UCHL1), a deubiquitin

61 amyloid-beta 1-42, neuropeptide Y (NPY), and ubiquitin C-terminal hydrolase L1 (UCHL1), whose CSF lev

62 ic enolase, glial fibrillary acidic protein, ubiquitin C-terminal hydrolase L1 [UCH-L1], neurofilamen

63 3% decrease; annexin VII, 8.8-fold increase; ubiquitin C-terminal hydrolase L1, 2.5-fold increase; AI

64 the ubiquitin-proteasome system, parkin and ubiquitin C-terminal hydrolase L1, are also associated w

65 associated with neurodegenerative diseases (ubiquitin C-terminal hydrolase L1, rat ortholog of human

66 ription of the binding site on ubiquitin for ubiquitin C-terminal hydrolase L3 (UCH-L3).

67 in (KIAA0603), a novel protein AK000009, the ubiquitin C-terminal hydrolase L3 (UCHL3) and an F-box/P

68 The mouse Uch-L3 (ubiquitin C-terminal hydrolase L3) gene was mapped withi

69 Here, we identified ubiquitin C-terminal hydrolase like 5 (UCHL5), a deubiqu

70 This might allow the ubiquitin C-terminal hydrolase to hydrolyze UbC1, in ord

71 The ubiquitin C-terminal hydrolase UCH-L1 (PGP9.5) comprises

72 report a novel interaction between Smads and ubiquitin C-terminal hydrolase UCH37, a deubiquitinating

73 members (USP4, USP15, USP11, and USP2), the ubiquitin C-terminal hydrolase UCHL3, and the Machado-Jo

74 d of K48 linkages, the proteasome-associated ubiquitin C-terminal hydrolase UCHL5/UCH37 serves as a p

75 accomplished in part by members of the UCH (ubiquitin C-terminal hydrolase) family of enzymes.

76 The human ubiquitin C-terminal hydrolase, UCH-L1, is an abundant n

77 lues, 0.34; 95% CI, 0.18-0.50; P < .001) and ubiquitin C-terminal hydrolase-L1 (mean difference in ln

78 f Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin C-Terminal Hydrolase-L1 (UCH-L1) in a cohort o

79 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is a highly e

80 Ubiquitin C-terminal hydrolase-L1 (UCH-L1) is linked to

81 The deubiquitinating enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) is required f

82 lenged by the linkage of the neuronal enzyme ubiquitin C-terminal hydrolase-L1 (UCH-L1) to Parkinson'

83 We show that a deubiquitinating enzyme, ubiquitin C-terminal hydrolase-L1 (UCH-L1), is highly ex

84 asma glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), neurofilamen

85 asma glial fibrillary acidic protein (GFAP), ubiquitin c-terminal hydrolase-L1 (UCH-L1), neurofilamen

86 Here we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1) abrogates the

87 Ubiquitin C-terminal hydrolase-L1 (UCHL1), a neuron-spec

88 Here, we show that Ubiquitin C-terminal hydrolase-L1 (UCHL1), which we prev

89 ed included glial fibrillary acidic protein, ubiquitin C-terminal hydrolase-L1, neurofilament light c

90 Glial fibrillary acidic protein, ubiquitin c-terminal hydrolase-L1, S100 calcium binding

91 , glial fibrillary acidic protein (GFAP) and ubiquitin C-terminal hydrolase.

92 enes, one of which encodes a neuron-specific ubiquitin C-terminal hydrolase.

93 Ubiquitin C-terminal hydrolases (UCH's) are a newly-defi

94 Ubiquitin C-terminal hydrolases (UCH) are deubiquitinati

95 Ubiquitin C-terminal hydrolases (UCHs) are a subset of d

96 Ubiquitin C-terminal hydrolases (UCHs) cleave Ub-X bonds

97 Ubiquitin C-terminal hydrolases (UCHs) comprise a family

98 Ubiquitin C-terminal hydrolases catalyze the removal of

99 However, p62 has homology neither with ubiquitin C-terminal hydrolases nor with the S5a subunit

100 quence of UCH-L1 is similar to that of other ubiquitin C-terminal hydrolases, including the ubiquitou

101 gy to the known de-ubiquitinating enzymes or ubiquitin C-terminal hydrolases.

102 served Cys and His domains characteristic of ubiquitin C-terminal hydrolases.

103 zymes, and UCH-L3, a member of the family of ubiquitin C-terminal hydrolases.

104 690 amino acid protein with high homology to ubiquitin C-terminal hydrolases.

105 in-ROS protein conjugates; and (iv) distinct ubiquitin C-terminal isopeptidase/hydrolase activities,

106 t peptide ubiquitination probes based on the ubiquitin C-terminal scaffold can be developed through a

107 As compared with native ubiquitin, C-terminal Tyr extension of ubiquitin results

108 ly weaker inhibitory activity towards UCHL5 (ubiquitin-C-terminal hydrolase-5).

109 The unanchored ubiquitin C termini in the aggregates are generated in s

110 ted signaling pathway, where the exposure of ubiquitin C termini within protein aggregates enables HD

111 These data suggest that binding the ubiquitin C terminus may be necessary for the function o

112 leaves substrate-linked ubiquitin within the ubiquitin C terminus, thereby inactivating it.

113 ly relevant and whether modifications of the ubiquitin C-terminus can modulate CXCR4 activation.

114 surface loops thereby allowing access of the ubiquitin C-terminus to the active site.

115 robes incorporate an azaglycine ester at the ubiquitin C-terminus.

116 ragments is a 1.2-kb sequence from the human ubiquitin C (UBC) gene, encompassing the promoter, some

117 In addition to these two genes, Ubiquitin C (UBC) in head and neck cancer and Transferri

118 ls and results in an exquisite dependence on ubiquitin C (UBC), the second polyubiquitin gene.