ライフサイエンスコーパス: ubiquitin ligase

1 ed that E2F8 is a direct target of the APC/C ubiquitin ligase.

2 oter with Parkin (PRKN), which encodes an E3 ubiquitin ligase.

3 5/Raf for degradation by the SEL-10/FBXW7 E3 ubiquitin ligase.

4 arget-binding domain directly fused to an E3 ubiquitin ligase.

5 s facilitates ubiquitination by the SIAH1 E3 ubiquitin ligase.

6 on (TDMD) required the ZSWIM8 Cullin-RING E3 ubiquitin ligase.

7 ngs its target protein in contact with an E3 ubiquitin ligase.

8 trates, including those mediated by the same ubiquitin ligase.

9 autoubiquitination and degradation of an E3 ubiquitin ligase.

10 ffects on ICP0 but not on Mdm2, a control E3 ubiquitin ligase.

11 bxo45, two components of an intracellular E3 ubiquitin ligase.

12 PCF11, by the cancer-specific MAGE-A11-HUWE1 ubiquitin ligase.

13 l components of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases.

14 h act as substrate adaptors of CUL3-based E3 ubiquitin ligases.

15 pecificity of ubiquitination is conferred by ubiquitin ligases.

16 ural basis for substrate recognition by MAGE ubiquitin ligases.

17 mechanisms in the control of NEDD4-1-related ubiquitin ligases.

18 s, transcriptional elongation factors and E3 ubiquitin ligases.

19 ngle-protein and multicomponent RING-type E3 ubiquitin ligases.

20 st growth factor 2 (FGF2) and Ariadne RBR E3 ubiquitin ligase 2 (ARIH2).

21 RLIM, also known as RNF12, is an X-linked E3 ubiquitin ligase acting as a negative regulator of LIM-d

22 f Clb1 and Cdc5, two substrates of a meiotic ubiquitin ligase activated by Ama1.

23 vitro evidence that Arabidopsis LNPs have E3 ubiquitin ligase activity and that LNP1 can directly ubi

24 Iso1 was heavily glycosylated with limited ubiquitin ligase activity for p53, resulting in p53 stab

25 429 phosphorylation selectively enhances the ubiquitin ligase activity of MDM2 homodimer but not MDM2

26 y p53 protein degradation mediated by the E3-ubiquitin ligase activity of MDM2.

27 rus (KSHV)-encoded LANA protein enhances the ubiquitin ligase activity of RLIM, leading to enhanced R

28 nts causing syndromic XLID and affecting the ubiquitin ligase activity of RLIM, suggesting that enzym

29 ferase domain of the SdeA, thus blocking the ubiquitin ligase activity of SdeA.

30 ylation, which is partially dependent on the ubiquitin ligase activity of TRAIP.

31 fects of the SUMO-SIM interaction on ICP0 E3 ubiquitin ligase activity regarding PML II degradation.

32 RPM-1 ubiquitin ligase activity restricts UNC-51 and autophago

33 ism by which ICP0 functions is through an E3 ubiquitin ligase activity that induces the degradation o

34 otility factor (AMF) receptor (AMFR) with E3 ubiquitin ligase activity that plays a significant role

35 e E3 Component N-Recognin7 (UBR7) harbors E3 ubiquitin ligase activity toward monoubiquitination of h

36 recruit PRC1 from extracts and enhance PRC1 ubiquitin ligase activity towards histone H2A.

37 TRAF6 E3 ubiquitin ligase activity was required for the former bu

38 uely independent of the RING domain encoding ubiquitin ligase activity.

39 thionine triggers rapid translocation of the ubiquitin ligase adaptor Art1 to the PM and dephosphoryl

40 highlight the critical importance of the E3 ubiquitin ligase adaptor KLHL15 in proteostasis of neuro

41 We propose that the PM-anchored Rsp5/Rcr1 ubiquitin ligase-adaptor complex can provide an acute re

42 of the anaphase promoting complex (APC/C) E3 ubiquitin ligase, Ama1.

43 e to a balance between the actions of the E3 ubiquitin ligase anaphase-promoting complex or cyclosome

44 MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial mem

45 In summary, UBR5 is a novel MYC ubiquitin ligase and an endogenous rheostat for MYC acti

46 sma membrane (PM) proteins requires the Rsp5 ubiquitin ligase and ART adaptor network.

47 e multi-step purification of a multi-subunit ubiquitin ligase and chemical cross-linking steps.

48 promoting complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle pr

49 d Pseudomonas effector AvrPtoB acts as an E3 ubiquitin ligase and promotes bacterial virulence.

50 The ubiquitin ligase and RQC factor Hel2/ZNF598 generally re

51 bserved downregulation of genes encoding H2A-ubiquitin ligase and StBMI1-1/3, and upregulation of Tri

52 Through the cooperative actions of E3 ubiquitin ligases and deubiquitinases, ubiquitin modific

53 ystem is the physical interaction between E3 ubiquitin ligases and deubiquitylases (DUBs).

54 Here, we screened more than 280 E3 ubiquitin ligases and discovered that the endoplasmic re

55 MAGEs assemble with E3 ubiquitin ligases and function as substrate adaptors tha

56 rtant insights into the large family of MAGE ubiquitin ligases and identify approaches for developing

57 lar bridge, where they recruit CUL4 and MDM2 ubiquitin ligases and the proteasome.

58 molecular level, many MAGEs bind to E3 RING ubiquitin ligases and, thus, regulate their substrate sp

59 luding those encoding MAGEA6 (a regulator of ubiquitin ligases) and LCP1 (an actin-binding protein),

60 biquitin binding protein, deubiquitinase and ubiquitin ligase, and its versatile role in various sign

61 n in the presence of drug, the levels of the ubiquitin ligase, and the expression level of competing

62 substrate adaptor for cullin3-containing E3 ubiquitin ligases, and KLHL15 gene mutations were recent

63 rgets of PfPP1 for egress: a HECT E3 protein-ubiquitin ligase; and GCalpha, a fusion protein composed

64 Ndc80 degradation depends on the ubiquitin ligase APC(Ama1) and is mediated by the protea

65 d interaction with cullin 4A-DBB1 (DCAF1) E3 ubiquitin ligase are required for REAF degradation by Vp

66 e protein kinases, protein phosphatases, and ubiquitin ligases are coordinated in space and time to r

67 The Siah1 and Siah2 ubiquitin ligases are implicated in diverse biological p

68 ent studies now show that the SidE family of ubiquitin ligases are regulated by a novel mechanism of

69 antagonistic roles of two closely related E3 ubiquitin ligases are required for netrin-1-dependent fi

70 ons in the PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessiv

71 5) protein, a putative adaptor of cullin3 E3 ubiquitin ligase, as a novel TRPM4-interacting protein.

72 strate recruiting subunit of the SCF-Skp2 E3 ubiquitin ligase, as an early repression target of pRb w

73 y immunoblots and in immunoprecipitation and ubiquitin ligase assays.

74 mechanism involves an Skp1/Cullin/F-box-type ubiquitin ligase: auxin, jasmonic acid, gibberellic acid

75 zed hFAST binds to the WD40 domain of the E3 ubiquitin ligase beta-TrCP and blocks its interaction wi

76 The conserved yeast E3 ubiquitin ligase Bre1 and its partner, the E2 ubiquitin-

77 to proteasomal degradation of mTOR by the E3 ubiquitin ligase c-Cbl.

78 ereas the screen suggested that Rnf20, an E3 ubiquitin ligase, can serve as a negative regulator of F

79 ch targeting BRD4 for degradation via the E3 ubiquitin ligase cereblon (CRBN) pathway leads to sustai

80 The ubiquitin ligase CHIP (C terminus of HSC70-interacting p

81 Here we identify a role for Cullin-RING ubiquitin ligase complex 4 (CRL4), known for modulating

82 ing out competitive binding to A3G or the E3 ubiquitin ligase complex as the sole mechanism.

83 The cereblon E3 ubiquitin ligase complex can recruit endothelial cell-sp

84 An E3 ubiquitin ligase complex CONSTITUTIVELY PHOTOMORPHOGENIC

85 We found that a modular E3 ubiquitin ligase complex CRL4(DCAF12) binds and targets

86 in the Kelch-like 3-Cullin 3 (KLHL3-CUL3) E3 ubiquitin ligase complex have shed light on the importan

87 In yeast, the Asi1/Asi2/Asi3 ubiquitin ligase complex safeguards the INM proteome thr

88 AI2), triggering its association with the E3 ubiquitin ligase complex SCF(MAX2) and downstream target

89 E3 ligase, assemble to form a receptor-like ubiquitin ligase complex that catalyzes the ubiquitinati

90 virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 en

91 and E4orf6, that together co-opt a cellular ubiquitin ligase complex to overcome host defences and p

92 te recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of immuno

93 molecular feedback loop via the COP1/SPA E3 ubiquitin ligase complex, suggesting a mechanism that ma

94 , a putative adaptor for the Cullin-3 (Cul3) ubiquitin ligase complex, which together with Cul3 is es

95 , that forms part of an SKP1/Cullin/F-box E3 ubiquitin ligase complex.

96 activation of the beta-TrCP1-containing SCF ubiquitin ligase complex.

97 rate receptor of the Cul4A-DDB1-CRBN-RBX1 E3 ubiquitin ligase complex.

98 ading to the membrane assembly of the 3-M E3 ubiquitin ligase complex.

99 regulator 1), an adaptor for CUL3 (CULLIN3) ubiquitin ligase complex.

100 BPM proteins are part of the Cullin E3 ubiquitin ligase complexes and are known to bind at leas

101 E3 ubiquitin ligase complexes facilitate the post-translati

102 ociated protein 2 (SKP2) as components of E3 ubiquitin ligase complexes that mediate YTHDF2 proteolys

103 egulate the mRNA expression of the predicted ubiquitin ligase component cullin cul-6, which promotes

104 ine hydroxylase (PHD, alias EGLN), and an E3 ubiquitin ligase component for HIF destruction called vo

105 Here, we find that loss of Fbxw7, an E3 ubiquitin ligase component, enhances the myelinating pot

106 ed alone, or together with other cullin-ring ubiquitin ligase components, which comprise a greatly ex

107 complex, or cyclosome (APC/C), is a large E3 ubiquitin ligase composed of 14 subunits.

108 their subsequent colocalization with the E3 ubiquitin ligase CONSTITUTIVE PHOTOMORPHOGENIC 1 (COP1),

109 changes in GA levels and depended on the E3 ubiquitin ligase CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1)

110 lia is regulated post-translationally by the ubiquitin ligase COP1 (also called RFWD2).

111 The Arabidopsis thaliana E3 ubiquitin ligase COP1 functions in ABA-mediated stomatal

112 We identified a cullin-RING ubiquitin ligase (CRL), containing the substrate adaptor

113 photoreceptors that negatively regulate the ubiquitin ligase CRL4(Cop1).

114 blon (CRBN), a substrate-receptor for the E3-ubiquitin ligase CRL4(CRBN), to trigger tau ubiquitinati

115 Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogeni

116 n-like protein that activates cullin-RING E3 ubiquitin ligases (CRLs).

117 rate that COP1, the substrate receptor of E3 ubiquitin ligase CUL4(COP) (1-) (SPA) (s) , interacts wi

118 new identified interaction partner is the E3 ubiquitin ligase cullin 3, which was revealed to regulat

119 Here, we report that the E3 ubiquitin ligase Cullin 5/RBX2 (CRL5) controls the stabi

120 We show that this pathway requires the ubiquitin ligase CULLIN-3, possibly mediating CRY-indepe

121 , we identified a P3-inducible U-box type E3 ubiquitin ligase, designated as P3-inducible protein 1 (

122 m Saccharomyces cerevisiae, we show that the ubiquitin ligase Doa10 (Teb-4/MARCH6 in animals) is a re

123 er-associated missense mutations in the RING ubiquitin ligase domain and a subset of mutations in the

124 n-containing 7 (FBXW7), a subunit of the SCF ubiquitin ligase, down-regulates spindle assembly 6 homo

125 However, unlike SidE ubiquitin ligases, DupA displays increased affinity to P

126 itination of sen2-1HA(ts) is mediated by the ubiquitin ligase (E3) Ubr1, while sam35-2HA(ts) is ubiqu

127 Ubiquitin ligases (E3s) embedded in the endoplasmic reti

128 iving substrate ubiquitination together with ubiquitin ligases (E3s), many E2s can also autoubiquitin

129 enign tumors, interacts with the cellular E3 ubiquitin ligase E6-associated protein (E6AP).

130 TRIM9 and TRIM67 are neuronally enriched E3 ubiquitin ligases essential for appropriate morphogenesi

131 d ubiquitination assays, we show that the E3 ubiquitin ligase F-box and WD repeat domain-containing 7

132 E3-ubiquitin ligase F-box and WD40 repeat domain containing

133 rs ERG recognition and degradation by the E3 ubiquitin ligase FBW7 in a manner independent of a canon

134 In this study, we show that the E3 ubiquitin ligase Fbw7 is required for the maintenance of

135 Ubiquitin ligase FBXO32 specifically inhibits epidermal

136 lly, we find that loss of the Elf5-regulated ubiquitin ligase FBXW7 ensures stabilization of its puta

137 result of its reduced degradation by the E3 ubiquitin ligase FBXW7.

138 beta-cat and transfers it to the SCF-TrCP E3-ubiquitin ligase for ubiquitination and destruction.

139 quitin protein ligase 1 (MIB1) as a novel E3 ubiquitin ligase for WRN protein.

140 Parkin is an E3 ubiquitin ligase, functioning in mitophagy.

141 We determine that the Siah2 E3 ubiquitin ligase functions in a coincidence detection ci

142 ing ubiquitination and three antagonistic E3 ubiquitin ligases: Grr1 and Ptr1 maintained basal Sir2 l

143 uctural analyses revealed that DupA and SidE ubiquitin ligases harbor a highly homologous catalytic p

144 La cell extracts and identify this as the E3 ubiquitin ligase, HECTD1.

145 ression and upregulation of MYC-regulated E3 ubiquitin ligases HECTD4 and MYCBP2, which promote AR an

146 Neuroprotective disruptions of the E3 ubiquitin ligase highwire and c-Jun N-terminal kinase ba

147 Here we show that during homeostasis, the E3 ubiquitin ligase Highwire and the ubiquitin-proteasome s

148 lex (LUBAC), which is composed of the two E3 ubiquitin ligases HOIP and HOIL-1L and the adaptor prote

149 OST1 (SnRK2.6) protein stability via the E3-ubiquitin ligase HOS15.

150 in-12-like) controls the stability of the E3 ubiquitin ligase Hrd1 (hydroxymethylglutaryl reductase d

151 o TQC enzymes, the ER-associated degradation ubiquitin ligase Hrd1 and zinc metalloprotease Ste24, pr

152 omic analysis reveals the upregulation of E3 Ubiquitin ligase HUWE1 and DUBs like USP9X and UBP7 in b

153 Strikingly, we report that depletion of the ubiquitin ligase HUWE1, or the histone acetyltransferase

154 ear bodies recruit both HIF-1alpha and an E3 ubiquitin ligase HUWE1, which promotes the ubiquitinatio

155 Previously, we identified E3 ubiquitin ligase IDOL as a negative regulator of brain l

156 o investigate a novel and uncharacterized E3 ubiquitin ligase in skeletal muscle atrophy, recovery fr

157 Our work reveals how redox-responsive E3 ubiquitin ligases in M. oryzae mediate Sir2 accumulation

158 omplished by the coordination of multiple E3 ubiquitin ligases, including Rsp5, the Dsc complex, and

159 d effector GRA15 mediates the recruitment of ubiquitin ligases, including TRAF2 and TRAF6, to the vac

160 The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) s

161 At least in yeast, the UBR1/UFD4 ubiquitin ligase interacts with the 26S proteasome, sugg

162 his work identified Mindbomb 1 (MIB1), an E3 ubiquitin ligase involved in neurodevelopment, as critic

163 , the Nedd4 family member in yeast, is an E3 ubiquitin ligase involved in numerous cellular processes

164 Parkin, an E3 ubiquitin ligase involved in Parkinson's disease, is a t

165 nscription factor SALL4 by the CRL4(CRBN) E3 ubiquitin ligase is a plausible major driver of thalidom

166 The RNF168 E3 ubiquitin ligase is activated in response to double stra

167 hat CRL4Mahj, an evolutionarily conserved E3 ubiquitin ligase, is essential for NSC reactivation (exi

168 a subunit of E3 Skp1/Cullin-1/F-box protein ubiquitin ligases, is modified by a prolyl hydroxylase t

169 polarization, which is regulated by itchy E3 ubiquitin ligase (ITCH), a negative regulator of inflamm

170 The E3 ubiquitin ligase, ITCH, negatively regulates the tumour

171 ue to alteration of the levels of any of the ubiquitin ligases known to ubiquitinylate p27(Kip1).

172 The MCC binds and inhibits the mitotic E3 ubiquitin ligase, known as Cdc20-anaphase promoting comp

173 otein interactions that, in the context of a ubiquitin ligase, lead to protein degradation(1).

174 g to murine double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradatio

175 chiatric risk gene Cul3, which encodes an E3 ubiquitin ligase, leads to an upregulation of Cap-depend

176 g (conjugated) Nt-Arg to the UBR1-RAD6 E3-E2 ubiquitin ligase, ligase-mediated synthesis of a substra

177 ed for its role in activating cullin-RING E3 ubiquitin ligases, little is known about other substrate

178 ) pathway targets for degradation via the E3 ubiquitin ligase Ltn1.

179 ve anti-cSCC activity of knockdown of the E3 ubiquitin ligase MARCH4, the ATPase p97/VCP, the deubiqu

180 ulate cellular gene expression.IMPORTANCE E3 ubiquitin ligases mark their substrates for degradation

181 In VZV-infected skin, kallikrein 6 and the ubiquitin ligase MDM2 are upregulated concomitant with k

182 ort a novel regulatory mechanism: another E3 ubiquitin ligase Mdm2 directly binds parkin and enhances

183 Its levels are tightly regulated by the E3 ubiquitin ligase MDM2.

184 RNA helicases and E3 ubiquitin ligases mediate many critical functions in cel

185 proteolytic pathway, in which UBR1 and UBR2 ubiquitin ligases mediate the degradation.

186 duced membrane-associated ring CH (MARCH) E3 ubiquitin ligase-mediated ubiquitination and downregulat

187 findings suggest a model in which the ZSWIM8 ubiquitin ligase mediates TDMD by directing proteasomal

188 s localization at cell membranes, where this ubiquitin ligase mediates the polyubiquitylation of memb

189 RING Finger ABA-Related1 (RFA1) and RFA4 E3 ubiquitin ligases, members of the RING between RING fing

190 Avadomide, a CRL4CRBN E3 ubiquitin ligase modulator, demonstrated clinical activi

191 the global chromatin response, we tested the ubiquitin ligase mutant uls1Delta, which selectively imp

192 ve recently identified that a HECT domain E3 ubiquitin ligase, named UBR5, is altered epigenetically

193 se models, we further discovered that the E3 ubiquitin ligase Nedd4 is required for developmental mye

194 re, we show that conditional deletion of the ubiquitin ligase Nedd4-2 (Nedd4l) in lung epithelial cel

195 Kidney-specific deletion of the ubiquitin ligase Nedd4-2 increases expression of NCC, an

196 o data suggest that LITAF interacts with the ubiquitin ligase NEDD4-2, a regulator of Nav1.5.

197 s been reported in the gene locus for the E3 ubiquitin ligase NEDD4.

198 ation and subsequent ubiquitination by an E3 ubiquitin ligase, NEDD4-1 (neural precursor cell-express

199 USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which mediates the degradation

200 RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by

201 n-regulation of the Crumbs complex by the E3 ubiquitin ligase Neuralized.

202 Infected cell protein 0 (ICP0), an E3 ubiquitin ligase of herpes simplex virus 1 (HSV-1), can

203 ge lymphoma (c-Cbl) is a recently identified ubiquitin ligase of nuclear beta-catenin and a suppresso

204 n of WRN have been reported, however, the E3 ubiquitin ligase of WRN is little known.

205 he functionally overlapping UBR1 and UBR2 E3 ubiquitin ligases of the Arg/N-degron pathway.

206 nscriptional activity and suggest that an E3 ubiquitin ligase other than FBXO25 regulates ELK-1 ubiqu

207 n Hippel-Lindau (VHL) and cereblon (CRBN) E3 ubiquitin ligases, our strategy enables light-triggered

208 Here, we identify E3 ubiquitin ligase PARK2 as a direct target of ELK1, a kno

209 o clear damaged mitochondria involves the E3 ubiquitin ligase Parkin and PTEN-induced kinase 1 (PINK1

210 Loss-of-function mutations in the E3 ubiquitin ligase parkin have been implicated in the deat

211 The E3 ubiquitin ligase parkin is a critical regulator of mitop

212 The E3 ubiquitin ligase Parkin promotes the degradation of dama

213 The ubiquitin ligase Parkin, protein kinase PINK1, USP30 deu

214 d23B, and Ddi2; the deubiquitylase Usp7, the ubiquitin ligase Parkin, the cochaperone Bag6, and the p

215 n with the Parkinson's disease-associated E3 ubiquitin ligase Parkin.

216 Here, we identified the E3 ubiquitin ligase Peli1 as an important regulator of T ce

217 rotein array technology, we identified an E3 ubiquitin ligase PIRE (PBL13 interacting RING domain E3

218 tically with the F-box protein FBXO25, an E3 ubiquitin ligase previously shown to promote ELK-1 ubiqu

219 s FZD degradation independent of ZNRF3/RNF43 ubiquitin ligases (R-spondin receptors).

220 UBR1-7, which are members of hundreds of E3 ubiquitin ligases, recognize and regulate the half-life

221 of the tripartite motif (TRIM) family of E3 ubiquitin ligases regulate immune pathways, including th

222 RING-CH (MARCH) family of membrane-bound E3 ubiquitin ligases regulates the levels of cell-surface m

223 e-promoting complex/cyclosome (APC/C), an E3 ubiquitin ligase, regulates the degradation of Mps3, a c

224 ARIH2 encodes TRIAD1, an E3 ubiquitin ligase required for termination of emergency g

225 mbrane-associated RING-CH 8 (MARCH8), the E3 ubiquitin ligase responsible for MHC II ubiquitination s

226 In yeast, the main ubiquitin ligase responsible for the sorting of proteins

227 Key players in the UPS are E3 ubiquitin ligases, responsible for conjugation of ubiqui

228 TRIM14, a noncanonical TRIM that lacks an E3 ubiquitin ligase RING domain, is a critical negative reg

229 The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B m

230 We found that eas-1 inhibits a conserved E3 ubiquitin ligase rnf-145/RNF145, which, in turn, promote

231 ylation that is targeted by a PAR-binding E3 ubiquitin ligase, RNF146, leading to 53BP1 polyubiquitin

232 by an ER membrane complex consisting of the ubiquitin ligase RNF185, the ubiquitin-like domain conta

233 Ubiquitin ligase RNF2, which silences genes by monoubiqu

234 The E3 ubiquitin ligase RNF4 contains multiple SIMs and connect

235 y stabilizing key melanoma oncoproteins, the ubiquitin ligase RNF4 promotes tumorigenesis and confers

236 we show that this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediat

237 Mice lacking the ubiquitin ligase RNF5 exhibit attenuated activation of t

238 NA interference screen, we found that the E3 ubiquitin ligase RNF8 suppresses a deletion rearrangemen

239 1/ULK kinase, is negatively regulated by the ubiquitin ligase RPM-1.

240 amily protein Art2/Ecm21, an adaptor for the ubiquitin ligase Rsp5, and its induction through the gen

241 ltiple replisome components that bind to the ubiquitin ligase SCF(Dia2).

242 y a proteolytic cascade consisting of the E3 ubiquitin ligases SCF(Mdm30) and Rsp5, and the Cdc48 cof

243 el, we identify IpaH7.8, a Shigella flexneri ubiquitin ligase secreted effector, as an enzyme that in

244 ability through polyubiquitylation by the E3 ubiquitin ligase Siah1.

245 We previously demonstrated that the E3 ubiquitin ligase SMURF2 plays a critical tumor suppressi

246 ction from DNA damage sites by SUMO-targeted ubiquitin ligase (STUbL) activity.

247 expression of monobodies fused to VHL, an E3 ubiquitin ligase substrate receptor, results in degradat

248 te ubiquitination by a member of the largest ubiquitin ligase subtype and reveal how a defined archit

249 at the promoter of the gene that encodes the ubiquitin ligase subunit FBXL7 is hypermethylated in adv

250 which recruits A3 proteins to cullin-RING E3 ubiquitin ligases such as cullin-5 (Cul5) for ubiquityla

251 res a dynamic network of redox-responsive E3 ubiquitin ligases targeting fungal sirtuin 2 (Sir2), an

252 A1 and CUL4 are components of a conserved E3 ubiquitin ligase that acts upstream of CrCO, whose regul

253 F(Met30) complex is an essential cullin-RING ubiquitin ligase that connects metabolic and heavy metal

254 motifs in RNF12/RLIM, a key developmental E3 ubiquitin ligase that is mutated in an intellectual disa

255 standing of TRAIP, a replisome-associated E3 ubiquitin ligase that is mutated in microcephalic primor

256 Parkin is an E3 ubiquitin ligase that is regulated by ubiquitination and

257 RLIM is an E3 ubiquitin ligase that leads to the ubiquitination and de

258 osphorylation (inhibition) of Nedd4-2, an E3 ubiquitin ligase that mediates hERG degradation.

259 L stabilizes p53 by sequestering MDM2, an E3 ubiquitin ligase that targets p53 for degradation, to th

260 RNF128 is an E3 ubiquitin ligase that targets p53 for degradation.

261 Von Hippel-Lindau (VHL) is an E3 ubiquitin ligase that targets proteins, including HIF-1a

262 library screen and identified ASB13 as an E3 ubiquitin ligase that targets SNAI2 for ubiquitination a

263 sistent collisions are detected by ZNF598, a ubiquitin ligase that ubiquitinates sites on the ribosom

264 Of this latter set, we identified the E3 ubiquitin ligase TNF receptor-associated factor 6 (TRAF6

265 ro-bifunctional molecules that recruit an E3 ubiquitin ligase to a given substrate protein resulting

266 s, such as HIV-1 Vif-mediated formation of a ubiquitin ligase to degrade virus-restrictive APOBEC3 en

267 made in understanding the contribution of E3 ubiquitin ligases to health and disease, including the p

268 ACT1 leading to the release of the essential ubiquitin ligase TRAF6 from the complex.

269 The E3 ubiquitin ligase TRIM21 plays a crucial role as a negati

270 mediated by the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21.

271 UBQLN2 function, the strongest hits were the ubiquitin ligase TRIM32 and two retroelement-derived pro

272 ibition depends on levels of the centrosomal ubiquitin ligase TRIM37.

273 ity, and social behavior in mice require the ubiquitin ligase TRIM67.

274 n (E) of ZIKV is polyubiquitinated by the E3 ubiquitin ligase TRIM7 through Lys63 (K63)-linked polyub

275 fibres, which releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing prot

276 cular constraints on von Hippel-Lindau (VHL) ubiquitin ligase tumor suppressor function.

277 The ubiquitin ligase, Ube3a, plays important roles in brain

278 This complex cooperates with cytosolic ubiquitin ligase UBE3C and p97 ATPase in degrading their

279 Here, we show that the ubiquitin ligase ubiquitin-like PHD and RING finger doma

280 idase, arginyltransferase, and the double-E3 ubiquitin ligase UBR1-RAD6/UFD4-UBC4/5 are shown to form

281 dase NTAQ1, arginyltransferase ATE1, and the ubiquitin ligase UBR1-UBE2A/B (or UBR2-UBE2A/B) form a c

282 gh the activity of the E7-associated host E3 ubiquitin ligase UBR4.

283 N14 and targets it for degradation using the ubiquitin ligase UBR4.

284 Here, we show how ubiquitin ligase UBR5 functions as a molecular rheostat

285 Parkin is an E3 ubiquitin ligase well-known for facilitating clearance o

286 regulates TRAIP, a RING domain-containing E3 ubiquitin ligase which dephosphorylates IkB and impedes

287 somes, RAB7 directly interacts with TRAF6 E3 ubiquitin ligase, which catalyzes K63 polyubiquitination

288 that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and prot

289 The NEURL1 ubiquitin ligase, which targets Notch ligands for degrad

290 Our study also identified an E3 ubiquitin ligase, which targets the RdDM compotent NRPD1

291 or by specific inhibition of the BMI/RING1A ubiquitin ligase, which would lead to increased cellular

292 In particular, BRCA1, an E3 ubiquitin ligase with a key role in several DNA repair p

293 to induce tripartite motif (TRIM) 21, an E3 ubiquitin ligase with critical functions in autoimmune d

294 s a poorly characterized RNA-binding RING E3-ubiquitin ligase with functions in embryonic development

295 HACE1 is an E3 ubiquitin ligase with important roles in tumor biology a

296 TRIM32 is an E3 ubiquitin ligase with innate antiviral activity.

297 The UBE3A gene encodes an E3 ubiquitin ligase with three known protein isoforms in hu

298 e Skp1-Cul1-F-box-protein (SCF) family of E3 ubiquitin ligases with the F-box protein Cyclin F at the

299 cells, we show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppressing transmembr

300 how that PTPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt sign