ライフサイエンスコーパス: ubiquitin ligase activity

1 the RING domain of Rbx1 and inhibits its E3 ubiquitin ligase activity.

2 nding H3K4me3 and H3K36me2 and exhibiting E3 ubiquitin ligase activity.

3 lex associated with Cbl and inhibited its E3 ubiquitin ligase activity.

4 members contain RING domains that impart E3 ubiquitin ligase activity.

5 localized to the ER membrane, and possesses ubiquitin ligase activity.

6 ears to be the RING finger, which confers E3 ubiquitin ligase activity.

7 ract with Dgrn and are substrates for its E3 ubiquitin ligase activity.

8 uely independent of the RING domain encoding ubiquitin ligase activity.

9 ental disorders associated with mutations in ubiquitin ligase activity.

10 hibitory activity, and significantly reduced ubiquitin ligase activity.

11 -Cullin-F-box (SCF) complexes that confer E3 ubiquitin ligase activity.

12 -kappaB activation through their RING domain ubiquitin ligase activity.

13 a RING domain deletion and the abrogation of ubiquitin ligase activity.

14 ted embryos, in a manner dependent on Trim36 ubiquitin ligase activity.

15 I kappaB alpha and decreased SCF(beta-TrCP) ubiquitin ligase activity.

16 hanges in the RLIM RING finger impaired RLIM ubiquitin ligase activity.

17 he F-box protein FSN-1, which mediates RPM-1 ubiquitin ligase activity.

18 display locomotion defects, dependent on the ubiquitin ligase activity.

19 wing to enhanced cIAP1, cIAP2 TRAF3-directed ubiquitin ligase activity.

20 HD fingers from a nuclear protein exhibit E3 ubiquitin ligase activity.

21 8 complex has a robust substrate-specific E3 ubiquitin ligase activity.

22 daptors in a mechanism independent of its E3 ubiquitin ligase activity.

23 We showed that RabGEF1's ZnF domain has ubiquitin ligase activity.

24 dentify small-molecule inhibitors of ICP0 E3 ubiquitin ligase activity.

25 on CHIP, a chaperone-binding protein with a ubiquitin ligase activity.

26 lated, and multiple subcomplexes may exhibit ubiquitin ligase activity.

27 of the sarcomere that are thought to possess ubiquitin ligase activity.

28 ha and may negatively affect its putative E3 ubiquitin ligase activity.

29 ral acidic domain of MDM2 and inhibit its E3 ubiquitin ligase activity.

30 Ran GTPase, and depends upon BRCA1/BARD1 E3 ubiquitin ligase activity.

31 by its N-terminal RING-CH domain, mK3 has E3 ubiquitin ligase activity.

32 urora-A Phe-31 variant exhibits an intrinsic ubiquitin ligase activity.

33 specific in vitro target of the BRCA1/BARD1 ubiquitin ligase activity.

34 ent and specific inhibitor of CHIP-dependent ubiquitin ligase activity.

35 quitin ligases, and we show that AvrPtoB has ubiquitin ligase activity.

36 thought to be due to the loss of parkin's E3 ubiquitin ligase activity.

37 and Rik1-TAP preparations exhibit robust E3 ubiquitin ligase activity.

38 1 to assemble an SCF(atrogin-1) complex with ubiquitin ligase activity.

39 gelman-associated mutations and a loss of E3 ubiquitin ligase activity.

40 heart that might be targets of its putative ubiquitin ligase activity.

41 cules that all possess a RING-CH domain with ubiquitin ligase activity.

42 uronal transmission and plasticity via their ubiquitin ligase activity.

43 lexes contain cullin 4A and Roc1 and display ubiquitin ligase activity.

44 homologous to the E6-AP Cterminus (HECT) E3 ubiquitin ligase activity.

45 igenetic modification directly regulating E3 ubiquitin ligase activity.

46 ion but is defective in self-association and ubiquitin ligase activity.

47 activity, yet it does not possess intrinsic ubiquitin ligase activity.

48 linos demonstrated the importance of Pellino ubiquitin ligase activity.

49 er domain that possesses non-conventional E3 ubiquitin ligase activity.

50 vity by HERC3 is independent of its inherent ubiquitin ligase activity.

51 alization and also significantly reduces its ubiquitin ligase activity.

52 interacted with MYCBP2 and inhibited its E3 ubiquitin ligase activity.

53 rim12-2) encodes a TRIM5-like protein with a ubiquitin ligase activity.

54 y, and this modification stimulates Trim7 E3 ubiquitin ligase activity.

55 quires PINK1 (PARK6), mitofusins, and parkin ubiquitin ligase activity.

56 adation of ubiquitinated target proteins via ubiquitin ligase activity.

57 a catalytic HECT domain essential for its E3 ubiquitin ligase activity.

58 n with a RING-H2 domain that has in vitro E3 ubiquitin ligase activity.

59 e important to HIV-1 restriction than its E3 ubiquitin ligase activity.

60 F4, that binds ubiquitin and supports its E3 ubiquitin ligase activity.

61 RK interactors and confirmed their predicted ubiquitin-ligase activity.

62 o the role of CAND1 in the regulation of SCF ubiquitin-ligase activity.

63 shown to regulate synaptogenesis through E3 ubiquitin ligase activities.

64 that regulates endocytic trafficking [6] and ubiquitin ligase activity [7, 8].

65 However, it is not known whether loss of E3 ubiquitin ligase activity accounts for the hematopoietic

66 , USP13 limits Siah2 autodegradation and its ubiquitin ligase activity against its target substrates.

67 PRP19 mutants unable to bind RPA or lacking ubiquitin ligase activity also fail to support RPA ubiqu

68 c-Cbl is a multifunctional molecule with ubiquitin ligase activity and a protein adaptor function

69 itide PI5P leads to stimulation of Cul3-SPOP ubiquitin ligase activity and also implicate PIPKIIbeta

70 The TRIM5alpha RING domain exhibits E3 ubiquitin ligase activity and assists the higher-order a

71 nhibit the BRCA1:E2 interaction show loss of ubiquitin ligase activity and correlate with disease sus

72 Purified TRIM5-21R had ubiquitin ligase activity and could autoubquitylate with

73 ation for a detailed understanding of its E3 ubiquitin ligase activity and DNA interstrand crosslink

74 protein in Arabidopsis, AtCHIP, also has E3 ubiquitin ligase activity and has important roles to pla

75 the HSV immediate-early protein ICP0 has E3 ubiquitin ligase activity and interacts with the proteas

76 RF61p RING finger domain is necessary for E3 ubiquitin ligase activity and is required for autoubiqui

77 r-suppressor complex BRCA1/BARD1 exhibits E3 ubiquitin ligase activity and participates in cell proli

78 The heterodimer contains an E3 ubiquitin ligase activity and participates in multiple c

79 ormation of a heterodimeric complex that has ubiquitin ligase activity and plays central roles in cel

80 cruited TRAF6, leading to increased TRAF6 E3 ubiquitin ligase activity and subsequent activation of A

81 s demonstrate that ErbB2 is a target of CHIP ubiquitin ligase activity and suggest a role for CHIP E3

82 This complex possesses E3 ubiquitin ligase activity and targets cellular proteins

83 vitro evidence that Arabidopsis LNPs have E3 ubiquitin ligase activity and that LNP1 can directly ubi

84 attenuation of anaphase-promoting complex/C ubiquitin ligase activity and the consequential stabiliz

85 r function of atrogin-1 was dependent on its ubiquitin ligase activity and the deposition of polyubiq

86 direct mechanism that is independent of its ubiquitin ligase activity and the interferon pathway.

87 EG protein has previously been shown to have ubiquitin ligase activity and to negatively regulate pro

88 ance of RAG-mediated histone recognition and ubiquitin ligase activities, and the role played by RAG

89 lin proteins in a process that alters SCF E3 ubiquitin ligase activity, and it is presumed that Nedd8

90 damaged mitochondria, activates Parkin's E3 ubiquitin ligase activity, and recruits Parkin to the dy

91 ments show that SUMOylated Rsp5p has reduced ubiquitin ligase activity, and similarly, ubiquitylated

92 Interestingly, Xnf7 exhibited intrinsic ubiquitin ligase activity, and this activity was require

93 The BRCA1 protein displays E3 ubiquitin ligase activity, and this enzymatic function i

94 tion between FADD and TRIM21 enhances TRIM21 ubiquitin ligase activity, and together they cooperative

95 Triad1 has E3 ubiquitin ligase activity, and we found that HoxA10-over

96 rotubules, exhibits RING-finger-dependent E3-ubiquitin-ligase activity, and has C-terminal-dependent

97 Conversely, ubiquitin ligase activities are opposed by UBP6/7, two p

98 Multiple DNA repair proteins having ubiquitin ligase activity are recruited to sites of DNA

99 Lipopolysaccharide-induced SCF(beta-TrCP) ubiquitin ligase activity as well as binding of beta-TrC

100 iviral activity of TRIM56 depended on its E3 ubiquitin ligase activity as well as the integrity of it

101 Gp78-induced mitophagy required ubiquitin ligase activity, as it is not observed upon tr

102 In vitro E3 ubiquitin ligase activity assays revealed that PRT4165 i

103 BRCA1 with components that contribute to its ubiquitin ligase activity, BARD1 and the E2 ubiquitin-co

104 The P326G substitution also abrogated ubiquitin ligase activity but had a less severe effect o

105 A-G252D still preserves self-association and ubiquitin ligase activity but loses membrane localizatio

106 7 is independent of the U-box domain with E3 ubiquitin ligase activity but requires the chaperone bin

107 ssay of Hrd1p function by demanding not only ubiquitin ligase activity, but also specific activity th

108 Some viral structural proteins require ubiquitin ligase activity, but not ubiquitin conjugation

109 The RING domain of TRIM5alpha exhibits E3-ubiquitin ligase activity, but the contribution of this

110 TRIM5alpha exhibits RING domain-dependent E3 ubiquitin ligase activity, but the specific role of this

111 experimentally tested mutations affected the ubiquitin ligase activity by either destabilizing CBL or

112 Here, we investigated the function of XIAP ubiquitin-ligase activity by inactivating the RING motif

113 whose protein product possesses potential E3 ubiquitin ligase activity, by recruiting the histone dea

114 d interactions also modulate TRIM5alpha's E3 ubiquitin ligase activity, by stereochemically restricti

115 red for normal V(D)J recombination, and RAG1 ubiquitin ligase activity can contribute when the protei

116 egulated manner and activate endogenous WWP2 ubiquitin ligase activity causing degradation of unstimu

117 ZEITLUPE (ZTL), a photoreceptor with E3 ubiquitin ligase activity, communicates end-of-day light

118 ent mutant (S98A) exhibited little change in ubiquitin ligase activity compared to wild-type TOPORS,

119 ired for stability of the FA core complex or ubiquitin ligase activity, CtBP1 is essential for prolif

120 We have previously shown that BRCA1 ubiquitin ligase activity directly inhibits centrosome-d

121 ned free from ubiquitin until a threshold of ubiquitin ligase activity enables degradation.

122 tions in its RING finger domain that disrupt ubiquitin ligase activity enhance stability.

123 Moreover, the c-Cbl mutant with impaired ubiquitin ligase activity (FLAG-70Z-Cbl) did not affect

124 ial mechanisms that govern WWP1/Tiul1 (WWP1) ubiquitin ligase activity, focusing on its ability to tr

125 Iso1 was heavily glycosylated with limited ubiquitin ligase activity for p53, resulting in p53 stab

126 nstrates a physiological requirement of XIAP ubiquitin-ligase activity for the inhibition of caspases

127 paralogues that together account for the E3 ubiquitin ligase activity found in PRC1 complexes, but n

128 The latter is achieved via MDM2's E3 ubiquitin ligase activity harbored within the MDM2 RING

129 L23, L26, or S7 to bind Mdm2 and inhibit its ubiquitin ligase activity has been suggested as a critic

130 Three families of proteins with ubiquitin ligase activity have been described (the HECT,

131 BL and serine 65 of ubiquitin fully activate ubiquitin ligase activity; however, a structural rationa

132 n and plasma membrane localization or Neurl1 ubiquitin ligase activity impair its ability to down-reg

133 melia virus and the variola virus possess E3 ubiquitin ligase activity in biochemical assays as well

134 Inhibition of c-Cbl expression or its ubiquitin ligase activity in cardiac myocytes offered pr

135 in and phospho-ubiquitin activated Parkin E3 ubiquitin ligase activity in cell-free assays.

136 ication of BRCA1, and are required for BRCA1 ubiquitin ligase activity in cells.

137 Disruption of E3 ubiquitin ligase activity in immature zebrafish mind bom

138 he E4-ORF3 protein displays no SUMO-targeted ubiquitin ligase activity in our assay system.

139 However, the requirement for Cbl ubiquitin ligase activity in this process and its mode o

140 ustrate the likely significant role of BRCA1 ubiquitin ligase activity in tumour suppression.

141 We show that Mind bomb protein displays E3 ubiquitin ligase activity in vitro and that it is associ

142 This region supports RING E3 ubiquitin ligase activity in vitro, but whether full-len

143 RING1 displays E3 ubiquitin ligase activity in vitro, which is dependent o

144 of root cells and recombinant AtSAP5 has E3 ubiquitin ligase activity in vitro.

145 the RING domains of all the proteins have E3 ubiquitin ligase activity in vitro.

146 RC and CUL7 subcomplexes examined exhibit E3 ubiquitin ligase activity in vitro.

147 id encodes a RING-containing protein with E3 ubiquitin ligase activity in vitro.

148 Like animal CHIP proteins, AtCHIP has E3 ubiquitin ligase activity in vitro.

149 otein product contains a RING domain and has ubiquitin ligase activity in vitro.

150 hat S1P is the missing cofactor for TRAF2 E3 ubiquitin ligase activity, indicating a new paradigm for

151 -finger domain (Flag-RINGmut) with deficient ubiquitin ligase activity, induces mitochondrial fragmen

152 and this is achieved by inhibition of the E3 ubiquitin ligase activity intrinsic to the RING of c-IAP

153 We demonstrate that E3 ubiquitin ligase activity is dispensable for EDD functio

154 et-restricted animals, indicating that WWP-1 ubiquitin ligase activity is essential for longevity.

155 Most importantly, TIF1gamma's E3 ubiquitin ligase activity is induced by histone binding.

156 monstrate that functional inhibition of Mdm2 ubiquitin ligase activity is insufficient for p53 activa

157 Our experiments show that mLANA's E3 ubiquitin ligase activity is necessary for efficient exp

158 LOG2 ubiquitin ligase activity is necessary for GDU1-dependen

159 tion in the absence of Rqc1; however, its E3 ubiquitin ligase activity is not required.

160 We further demonstrate that MAGE-L2-TRIM27 ubiquitin ligase activity is required for nucleation of

161 Parkin's E3 ubiquitin ligase activity is required to ubiquitinate ou

162 o-ubiquitination may influence its substrate ubiquitin ligase activity is undefined.

163 poptotic thymocytes, demonstrating that XIAP ubiquitin-ligase activity is a major determinant of XIAP

164 c-Cbl), adaptor protein with an intrinsic E3 ubiquitin ligase activity, is involved in FA and myofibr

165 ncodes a RING domain protein associated with ubiquitin ligase activity, lead to autosomal recessive P

166 The initial increase in parkin's E3 ubiquitin ligase activity leads to autoubiquitination of

167 ent of pharmacological inhibitors of LANA E3 ubiquitin ligase activity may allow strategies to interf

168 known enzymatic function of BRCA1 is the E3 ubiquitin ligase activity mediated by its highly conserv

169 The Rad5 ubiquitin ligase activity mediates PCNA poly-ubiquitinat

170 data indicate that Skp1 and possibly E3(SCF)ubiquitin-ligase activity modulate O(2)-dependent culmin

171 tural, since neither the inactivation of its ubiquitin ligase activity nor the inactivation of its he

172 rexpression studies demonstrate that Rabex-5 ubiquitin ligase activity, not its Rab5 GEF activity, is

173 Comparisons of the H2A ubiquitin ligase activities of these different complexes

174 In mitosis, Cdc20 binds to and activates the ubiquitin ligase activity of a large molecular machine c

175 ) restriction of HIV-1, we correlated the E3-ubiquitin ligase activity of a panel of TRIM5alpha(rh) R

176 osphorylates Cdc20 in vitro and inhibits the ubiquitin ligase activity of APC/C(Cdc20) catalytically.

177 gregation, the spindle checkpoint blocks the ubiquitin ligase activity of APC/C(Cdc20) in response to

178 The E3 ubiquitin ligase activity of both proteins activates NFk

179 Surprisingly, cells lacking the ubiquitin ligase activity of BRCA1 are viable and do not

180 protein phosphatase 1 alpha enhances the E3 ubiquitin ligase activity of BRCA1.

181 of centrosome function by decreasing the E3 ubiquitin ligase activity of BRCA1.

182 ion in vitro and in vivo and identify the E3 ubiquitin ligase activity of breast cancer type 1 suscep

183 These results suggest that the self-ubiquitin ligase activity of c-IAPs is inhibited by USP1

184 e show a strict requirement for Grb2 and the ubiquitin ligase activity of Cbl for cMet endocytosis.

185 These results indicate that the ubiquitin ligase activity of Cbl is critical for clathri

186 Although the ubiquitin ligase activity of CHIP requires its dimerizat

187 Likewise, the ubiquitin ligase activity of CHIP was dispensable for Ta

188 We further demonstrate the E3 ubiquitin ligase activity of COP1 on HY5 in vitro and th

189 ulation of the p38 MAPK pathway enhances the ubiquitin ligase activity of Cul3-SPOP toward multiple s

190 Reciprocally, CSN inhibits the ubiquitin ligase activity of deneddylated Cul1.

191 the exception of HERC2, which modulates the ubiquitin ligase activity of E6AP, little is known about

192 unit nuclear complex that facilitates the E3 ubiquitin ligase activity of FANCL.

193 The ubiquitin ligase activity of HACE1 in mitotic Golgi disa

194 e segments of Hrd1p, and depends on both the ubiquitin ligase activity of Hrd1p and the function of t

195 Efficient rescue required the ubiquitin ligase activity of Itch and an intact C2 domai

196 that uncouples nucleolar localization and E3 ubiquitin ligase activity of Mdm2 and leads to upregulat

197 429 phosphorylation selectively enhances the ubiquitin ligase activity of MDM2 homodimer but not MDM2

198 so showed that EBNA3C enhances the intrinsic ubiquitin ligase activity of Mdm2 toward p53, which in t

199 st that MTBP differentially regulates the E3 ubiquitin ligase activity of MDM2 towards two of its mos

200 Both Nbs1 and ATM, but not the ubiquitin ligase activity of Mdm2, were necessary to inh

201 y p53 protein degradation mediated by the E3-ubiquitin ligase activity of MDM2.

202 We speculate that the target of the E3 ubiquitin ligase activity of Msc1 is likely to be a chro

203 nsistent with this, calcium activates the E3 ubiquitin ligase activity of Nedd4.

204 tion of virus budding was dependent upon the ubiquitin ligase activity of NEDD4L and required only th

205 Here we tested whether the ubiquitin ligase activity of parkin could lead to reduct

206 kinase activity releases the auto-inhibited ubiquitin ligase activity of Parkin remains unclear.

207 um and oxidative stressors presumably due to ubiquitin ligase activity of parkin that targets protein

208 oplasm, with Pink1 and DJ-1 promoting the E3 ubiquitin ligase activity of Parkin to degrade substrate

209 ere, we discover that the histone H2AK119 E3 ubiquitin ligase activity of Polycomb repressive complex

210 tion of a mutant, pub1-1, affected by the E3 ubiquitin ligase activity of PUB1, we have shown that th

211 s demonstrate that MAGE proteins enhance the ubiquitin ligase activity of RING domain proteins.

212 plexes revealed that Bmi1 stimulates the H2A ubiquitin ligase activity of Ring2 (and Ring1).

213 rus (KSHV)-encoded LANA protein enhances the ubiquitin ligase activity of RLIM, leading to enhanced R

214 nts causing syndromic XLID and affecting the ubiquitin ligase activity of RLIM, suggesting that enzym

215 ty and mono-ubiquitination, dependent on the ubiquitin ligase activity of RNF31.

216 modification of cullins by CSN inhibits the ubiquitin ligase activity of SCF complexes in vitro.

217 This interaction allows Ras to stimulate the ubiquitin ligase activity of SCF(beta-TrCP) toward its t

218 ferase domain of the SdeA, thus blocking the ubiquitin ligase activity of SdeA.

219 a novel adaptor that physically links the E3 ubiquitin ligase activity of Siah-1 with Skp1 and Ebi F-

220 Both the kinase activity of SIK1 and the ubiquitin ligase activity of Smurf2 are important for pr

221 The ubiquitin ligase activity of the anaphase-promoting comp

222 ctivates this checkpoint, which inhibits the ubiquitin ligase activity of the anaphase-promoting comp

223 gned chromosomes, Bub1 directly inhibits the ubiquitin ligase activity of the anaphase-promoting comp

224 mitosis, the spindle checkpoint inhibits the ubiquitin ligase activity of the anaphase-promoting comp

225 ediated interference markedly reduces the E3 ubiquitin ligase activity of the APC/C and the progressi

226 eines 8, 33 and 49 of Aurora-A abolishes the ubiquitin ligase activity of the protein.

227 The C325Y substitution severely abrogated ubiquitin ligase activity of the purified RAG1 RING fing

228 ion assays show that AvrPiz-t suppresses the ubiquitin ligase activity of the rice RING E3 ubiquitin

229 The E3 ubiquitin ligase activity of the RING domain contributes

230 To test the hypothesis that the E3-ubiquitin ligase activity of the RING domain modulates T

231 of NF-kappaB by XIAP was dependent on the E3 ubiquitin ligase activity of the RING domain.

232 esistance and imply a crucial role of the E3 ubiquitin ligase activity of this domain in MDM2-mediate

233 increased neddylation and elevated intrinsic ubiquitin ligase activity of this E3.

234 aspartic acid resulted in an increase in the ubiquitin ligase activity of TOPORS both in cells and in

235 based on cell-free systems, the role of the ubiquitin ligase activity of TRAF6 and its auto-ubiquiti

236 osphorylation status, and interfere with the ubiquitin ligase activity of TRAF6.

237 ylation, which is partially dependent on the ubiquitin ligase activity of TRAIP.

238 ote TLR3 signaling was independent of the E3 ubiquitin ligase activity of TRIM56.

239 These genetic findings suggest that the ubiquitin ligase activity of UBE3A must be tightly maint

240 interacts with WWP-1 and is required for the ubiquitin ligase activity of WWP-1 and the extended long

241 We also find that CCS is a target of the E3 ubiquitin ligase activity of XIAP, although interestingl

242 roximal chromatin and that disruption of the ubiquitin-ligase activity of Asr1--or mutation of ubiqui

243 creased SfIAP turnover independent of the E3 ubiquitin-ligase activity of the SfIAP RING, which also

244 a TOM complex, recruits Parkin and activates ubiquitin ligase activity on the respective organelles.

245 mind bomb (mib) mutation, which disrupts E3 ubiquitin ligase activity, or by treatment with gamma-se

246 of RAG1, which can be promoted by RAG1's own ubiquitin ligase activity, plays a significant role in g

247 itosis and suggest that a reduction in APC/C ubiquitin ligase activity promotes SAC activation.

248 itosis and suggest that a reduction in APC/C ubiquitin ligase activity promotes SAC activation.Oncoge

249 thyltransferase PRMT1, and this inhibits its ubiquitin ligase activity, reducing activation of toll-l

250 fects of the SUMO-SIM interaction on ICP0 E3 ubiquitin ligase activity regarding PML II degradation.

251 e have shown earlier that the BRCA1/BARD1 E3 ubiquitin ligase activity regulates centrosome-dependent

252 ith the kinase domain of XA21 and for its E3 ubiquitin ligase activity, respectively.

253 The FA core complex has ubiquitin ligase activity responsible for monoubiquitina

254 RPM-1 ubiquitin ligase activity restricts UNC-51 and autophago

255 activation of Nrf2 through inhibition of E3 ubiquitin ligase activity, resulting in increased levels

256 DHX15 stabilized Siah2 and enhanced its E3 ubiquitin-ligase activity, resulting in AR activation.

257 TRIM5alpha(rh) mutants without detectable E3 ubiquitin ligase activity still blocked reverse transcri

258 P0 stimulates efficient infection via its E3 ubiquitin ligase activity that causes degradation of sev

259 evidence has indicated that TRAF6 possesses ubiquitin ligase activity that controls the activation o

260 gene encoding Act1, an adaptor protein with ubiquitin ligase activity that couples the IL-17 recepto

261 gene coding for a protein with intrinsic E3 ubiquitin ligase activity that has not previously been f

262 ism by which ICP0 functions is through an E3 ubiquitin ligase activity that induces the degradation o

263 BARD1) to form a heterodimer, which exhibits ubiquitin ligase activity that is abrogated by known can

264 ndicated that the SPL11 protein possesses E3 ubiquitin ligase activity that is dependent on an intact

265 tudies provide the first identification of a ubiquitin ligase activity that is involved in the DNA da

266 he L. pneumophila effector GobX possesses E3 ubiquitin ligase activity that is mediated by a central

267 ICP0 has a RING finger domain with E3 ubiquitin ligase activity that is necessary for IE funct

268 otility factor (AMF) receptor (AMFR) with E3 ubiquitin ligase activity that plays a significant role

269 ng UbcH5c as ubiquitin-conjugating enzyme, a ubiquitin ligase activity that polyubiquitinates p12 was

270 ) is an adaptor protein with an intrinsic E3 ubiquitin ligase activity that targets receptor and nonr

271 Purified p300 exhibited intrinsic ubiquitin ligase activity that was inhibited by E1A.

272 While the Ring domain has E3 ubiquitin ligase activity, the BRCA1 BRCT domains specif

273 Consistent with suppression due to impaired ubiquitin ligase activity, the heat-sensitive growth def

274 In addition to E3 ubiquitin ligase activity, the Mdm2 RING preferentially

275 hanism may not be that simple since TRIM5 E3 ubiquitin ligase activity, the proteasome, autophagy, an

276 own results in a specific reduction in APC/C ubiquitin ligase activity, the stabilization of APC/C su

277 These data link the loss of ubiquitin ligase activity, through loss of E2-binding, t

278 ion of different domains of BRCA1 and its E3 ubiquitin ligase activity to HDR and drug resistance.

279 Pharmacologic agents that modulate ubiquitin ligase activity to induce protein degradation

280 We find that D-mib uses its ubiquitin ligase activity to promote DSL ligand activity

281 role for Grb2 as an intermediary linking Cbl ubiquitin ligase activity to this process.

282 and mutant RNF170 have apparently identical ubiquitin ligase activities toward IP3 receptors.

283 G finger domain of MEKK1, which exhibited E3 ubiquitin ligase activity toward c-Jun in vitro and in v

284 orphogenesis 1 (COP1) and that COP1 exhibits ubiquitin ligase activity toward HFR1 in vitro.

285 ith PHD and RING finger domains 1 (UHRF1) E3 ubiquitin ligase activity toward histone H3, a mechanism

286 e E3 Component N-Recognin7 (UBR7) harbors E3 ubiquitin ligase activity toward monoubiquitination of h

287 milar to RPL5 and RPL23, and inhibits its E3 ubiquitin ligase activity toward p53.

288 in these cells, Cul3Delta9 supported reduced ubiquitin ligase activity toward RhoA compared with equi

289 We conclude that Cul3Delta9-associated ubiquitin ligase activity toward RhoA is impaired and su

290 ted TRIM32 mutations, D487N and R394H impair ubiquitin ligase activity towards dysbindin and were mis

291 recruit PRC1 from extracts and enhance PRC1 ubiquitin ligase activity towards histone H2A.

292 te in Smurf is shown to be necessary for its ubiquitin ligase activity towards the substrate and also

293 TRIM5alpha(AGM) ubiquitin ligase activity was essential for both the acc

294 Parkin HECT-like ubiquitin ligase activity was essential for PINK1-mediat

295 Experimental CBL ubiquitin ligase activity was in agreement with the pred

296 TRAF6 E3 ubiquitin ligase activity was required for the former bu

297 f the viral protein ICP0, which possesses E3 ubiquitin ligase activity, was both necessary and suffic

298 Unexpectedly, p300/CBP ubiquitin ligase activities were absent in nuclear extra

299 degradation with both chaperone binding and ubiquitin ligase activities, which are mediated by its T

300 ional changes of the CARD determine c-IAP1's ubiquitin ligase activity, with implications for regulat