ライフサイエンスコーパス: ubiquitin ligase complex

1 ain (which mediates interactions with the E3 ubiquitin ligase complex).

2 , thereby blocking formation of a functional ubiquitin ligase complex.

3 recognition component of the SCF(beta-TrCP) ubiquitin ligase complex.

4 logous to the cellular Skp1-Cul1-F-box (SCF) ubiquitin ligase complex.

5 component of the Skp1/Cullin1/F-box protein ubiquitin ligase complex.

6 uired for targeting TDG to the CRL4(Cdt2) E3 ubiquitin ligase complex.

7 ts YAP1 for degradation via the betaTrCP-SCF ubiquitin ligase complex.

8 L4A to cause ubiquitination through the CRL4 ubiquitin ligase complex.

9 bstrate receptor for the Skp1-Cul1-Rbx1/Roc1 ubiquitin ligase complex.

10 x component of the Skp-Cullin-F-box (SCF) E3 ubiquitin ligase complex.

11 , that forms part of an SKP1/Cullin/F-box E3 ubiquitin ligase complex.

12 disrupting its interaction with TRAF2.cIAP2 ubiquitin ligase complex.

13 's ability to bind the cellular beta-TrCP-E3-ubiquitin ligase complex.

14 nical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex.

15 with Skp2, a key component of the SCF(skp2) ubiquitin ligase complex.

16 activation of the beta-TrCP1-containing SCF ubiquitin ligase complex.

17 in a Cul5-independent manner by RhoBTB3-Cul3 ubiquitin ligase complex.

18 hromatin structure independently of the CRL4 ubiquitin ligase complex.

19 for the SCF (Skip1-Cullin1-F-box protein) E3 ubiquitin ligase complex.

20 2 mutant that does not participate in the E3 ubiquitin ligase complex.

21 the transcription cofactor CBF-beta to this ubiquitin ligase complex.

22 function as adaptors for the Cullin-3 (Cul3) ubiquitin ligase complex.

23 rate receptor of the Cul4A-DDB1-CRBN-RBX1 E3 ubiquitin ligase complex.

24 hich is the substrate-binding component of a ubiquitin ligase complex.

25 and SLX8, encoding the sumoylation-targeted ubiquitin ligase complex.

26 factor and a ligand-dependent adaptor in an ubiquitin ligase complex.

27 mplex/cyclosome and its coactivator Cdh1) E3 ubiquitin ligase complex.

28 ading to the membrane assembly of the 3-M E3 ubiquitin ligase complex.

29 e adaptor for an SCF (Skp-Cullin 1-F box) E3 ubiquitin ligase complex.

30 regulator 1), an adaptor for CUL3 (CULLIN3) ubiquitin ligase complex.

31 are members of the Skp, Cullin, F box (SCF) ubiquitin ligase complex.

32 mponents of the Skp1-Cullin-F-box (SCF) type ubiquitin ligase complex.

33 equired for assembly of a functional Cul5-E3 ubiquitin ligase complex.

34 functions independent of the VHL/elongin E3 ubiquitin ligase complex.

35 TAT1 for proteasomal degradation via the VDC ubiquitin ligase complex.

36 proteins, by recruitment of the SCF(Skp2) E3 ubiquitin ligase complex.

37 p is a recently discovered member of the HRD ubiquitin ligase complex.

38 initiation factor Cdt1 via the CRL4(Cdt2) E3 ubiquitin ligase complex.

39 can recruit key components of the SCF(Skp2) ubiquitin ligase complex.

40 BD1 and R-domain and are sensed by the RMA-1 ubiquitin ligase complex.

41 iting factor for p21 to the rest of the CRL4 ubiquitin ligase complex.

42 substrate recognition subunit of a Cullin-2 ubiquitin ligase complex.

43 biquitinated and degraded via the SCF(Fbxl3) ubiquitin ligase complex.

44 tion, which induces binding to the SCF(Fbw7) ubiquitin ligase complex.

45 ith HSP90 and recruitment of the Elongin-C/B ubiquitin ligase complex.

46 ubstrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex.

47 nent of the SKP1-CUL1-F-box-protein (SCF) E3 ubiquitin ligase complex.

48 d F box protein, suggesting a role in an SCF ubiquitin ligase complex.

49 viously shown that CSA is a subunit of an E3 ubiquitin ligase complex.

50 DB2), which is part of a multiprotein UV-DDB ubiquitin ligase complex.

51 dge the BRD9 bromodomain and the cereblon E3 ubiquitin ligase complex.

52 teins function as adaptors of the Cullin3 E3 ubiquitin ligase complex.

53 reased activity of a CUL-6/cullin-containing ubiquitin ligase complex.

54 at CLC-1 degradation is mediated by cullin 4 ubiquitin ligase complex.

55 e role of Ddb1, a component of the CUL4-DDB1 ubiquitin ligase complex.

56 phthalimide moiety to hijack the cereblon E3 ubiquitin ligase complex.

57 ate adaptor for the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligase complex.

58 such as SEL-10, are components of the SCF E3 ubiquitin-ligase complex.

59 Cullin 3 (Cul3) and linking GluR6 to the E3 ubiquitin-ligase complex.

60 en) using the RAD6-RAD18 and UBC13-MMS2-RAD5 ubiquitin ligase complexes.

61 e is reminiscent of multisubunit cullin-RING ubiquitin ligase complexes.

62 evelopment by modulating the activity of SCF ubiquitin ligase complexes.

63 MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.

64 ng subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes.

65 n the formation of cullin 3 (Cul3)-dependent ubiquitin ligase complexes.

66 r HIF-1alpha, which are substrates for other ubiquitin ligase complexes.

67 tiple steps of this process are regulated by ubiquitin ligase complexes.

68 strate ubiquitination by cullin-dependent E3 ubiquitin ligase complexes.

69 the substrate receptor of 1 of 69 human SCF ubiquitin ligase complexes.

70 CAF12, a putative cofactor of Cullin4 (Cul4) ubiquitin ligase complexes.

71 logy that encodes a component of SCF-type E3 ubiquitin ligase complexes.

72 -ubiquitination and proteolysis by Cullin-E3 ubiquitin-ligase complexes.

73 Here we identify a role for Cullin-RING ubiquitin ligase complex 4 (CRL4), known for modulating

74 s mediated by the activity of the CRL4(Cdt2) ubiquitin ligase complex [5, 13, 14].

75 nt of the SCF (Skp1/Cullin/F-box protein) E3 ubiquitin ligase complex acts as a tumor suppressor in s

76 echanism for assembly of the BIV Vif-APOBEC3 ubiquitin ligase complex advances our understanding of v

77 more, knockdown of other members of the Cul3 ubiquitin ligase complex also led to increased cytokine

78 se agents bind to cereblon, a component of a ubiquitin ligase complex, altering the specificity of th

79 ubunit 1 (Cks1), a cofactor of the SCF(Skp2) ubiquitin ligase complex and a downstream target of MYC,

80 We reconstituted the functional human H2A ubiquitin ligase complex and a panel of subcomplexes of

81 bind to the ubiquitously expressed cereblon ubiquitin ligase complex and alter its substrate specifi

82 f these photoreceptors, such as SPA1/COP1 E3 ubiquitin ligase complex and bHLH transcription factors

83 s paper, we characterize the gp78-containing ubiquitin ligase complex and define its functional inter

84 ROTEIN1 (SKP1)/Cullin/F-box protein (SCF) E3 ubiquitin ligase complex and directly interact with type

85 HINT1 directly interacts with the SCF(SKP2) ubiquitin ligase complex and inhibits the ubiquitylation

86 usly ubiquitylated by the KEAP1-CUL3-RBX1 E3 ubiquitin ligase complex and is targeted to the proteaso

87 bstrate recognition adaptor of CRL4(Cdt2) E3 ubiquitin ligase complex and plays a pivotal role in the

88 Vpr involved in binding to the DCAF1/DDB1/E3 ubiquitin ligase complex and prevention of cell cycle pr

89 SPA1 act in concert to form a functional E3 ubiquitin ligase complex and provide a molecular basis f

90 -L1 disrupts a complex between the DDB1-CUL4 ubiquitin ligase complex and raptor and counteracts DDB1

91 netic screen, we found the Ddb1-Cul4(Cdt)(2) ubiquitin ligase complex and ribonucleotide reductase (R

92 BOK is ubiquitylated by the AMFR/gp78 E3 ubiquitin ligase complex and targeted for proteasomal de

93 , Nrf2 is ubiquitinated by the Keap1-Cul3-E3 ubiquitin ligase complex and targeted to the 26S proteas

94 factor for the Skp1-Cul1-F-box protein (SCF) ubiquitin ligase complex and targets several proteins re

95 s targeted for degradation by the SCF(Slimb) ubiquitin ligase complex and that disruption of this pro

96 ciated with an enzymatically active cullin 2 ubiquitin ligase complex and that the HPV16 E7/pRB compl

97 ent mechanism that requires the Golgi Dsc E3 ubiquitin ligase complex and the proteasome.

98 he interaction of Vpr with the DCAF1/DDB1 E3 ubiquitin ligase complex and the yet-to-be-identified ho

99 BPM proteins are part of the Cullin E3 ubiquitin ligase complexes and are known to bind at leas

100 horylation of Ci/Gli triggers binding to SCF ubiquitin ligase complexes and consequent proteolysis.

101 insights into the operation of cullin-based ubiquitin ligase complexes and potential means by which

102 ial for their recognition by pVHL containing ubiquitin ligase complexes and subsequent degradation in

103 synthesized membrane proteins are queried by ubiquitin ligase complexes and triaged between degradati

104 he von Hippel-Lindau protein (VHL)-Elongin C ubiquitin-ligase complex and degradation by the 26 S pro

105 osome (APC/C), which is the largest known E3 ubiquitin-ligase complex and has been implicated in regu

106 Hippel-Lindau (VHL; a protein component of a ubiquitin ligase complex) and hypoxia-inducible factors

107 ts ubiquitylation by targeting the SCF(SKP2) ubiquitin ligase complex, and 2) it inhibits the phospho

108 te recruiter element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of immuno

109 tein COP1 has been shown to operate as an E3 ubiquitin ligase complex, and a number of putative subst

110 in of the Skp1-Cullin-F-box protein (SCF) E3 ubiquitin ligase complex, and promotes the stability of

111 ctly with the Skp1 component of the host SCF ubiquitin ligase complex, and that the binding of M-T5 t

112 n Hippel-Lindau (VHL)/Elongin-C/Elongin-B E3 ubiquitin ligase complex, and the proteasome.

113 n1/Cullin1/F-box protein COI1 (SCF(COI1)) E3 ubiquitin ligase complex, and their degradation by the 2

114 ullin3 (Cul3), a scaffolding component of E3 ubiquitin ligase complexes, and the previously uncharact

115 During S and G2 phases the ubiquitin ligase complex APC/C is inhibited by Emi1 prot

116 Strikingly, selected E2 and E3 components of ubiquitin ligase complexes are enriched by this mechanis

117 is subject to degradation by the CRL4(Cdt2) ubiquitin ligase complex as a function of the cell cycle

118 Our studies identify the Cul4-DDB1[VprBP] E3 ubiquitin ligase complex as the downstream effector of l

119 ing out competitive binding to A3G or the E3 ubiquitin ligase complex as the sole mechanism.

120 UL4, components of a putative green algal E3 ubiquitin ligase complex, as critical factors in a signa

121 cle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer memb

122 of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complexes) binds IP3R3 and targets it f

123 a, a member of the Skp1/Cullin/Rbx1/F-box E3 ubiquitin ligase complex, binds directly to p300 and co-

124 requires ubiquitination of Gap1p by an Rsp5p ubiquitin ligase complex, but amino acid abundance does

125 red Skp2, a substrate-binding subunit of SCF ubiquitin ligase complexes, but also relied on CHIP, a c

126 AMHD1 is recruited to the CRL4(DCAF1-Vpx) E3 ubiquitin ligase complex by interacting with the DCAF1 s

127 protein) is part of a large multi-protein E3 ubiquitin ligase complex called LUBAC (linear ubiquitin

128 The cereblon E3 ubiquitin ligase complex can recruit endothelial cell-sp

129 t includes upregulation of several predicted ubiquitin ligase complex components such as the cullin c

130 These screens uncovered genes that encode a ubiquitin ligase complex, components of the PtdIns 3-kin

131 s part of a Cullin3 (CUL3)-dependent RING-E3 ubiquitin ligase complex comprised of RhoBTB3, CUL3, and

132 An E3 ubiquitin ligase complex CONSTITUTIVELY PHOTOMORPHOGENIC

133 An E3 ubiquitin ligase complex containing FBXL5 targets IRP2 f

134 The ubiquitin ligase complex containing Pam-Fbxo45 likely ta

135 This modification, in turn, enables a ubiquitin ligase complex containing the cullin Rtt101 to

136 IM-domain (JAZ) repressor proteins and an E3 ubiquitin ligase complex containing the F-box CORONATINE

137 latory role played by the Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-t

138 We found that an E3 ubiquitin ligase complex containing the FBXL5 protein ta

139 ducible factor-alpha for ubiquitination by a ubiquitin ligase complex containing the von Hippel-Linda

140 the host's antiviral defence by hijacking a ubiquitin ligase complex, containing CUL5, ELOC, ELOB an

141 ropose that the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degrada

142 port that a previously unstudied SCF(FBXO22) ubiquitin ligase complex controls the activity of KDM4A

143 The SCF(FBXL3) ubiquitin ligase complex controls this negative feedback

144 or MLN4924, which inhibits the cullin1-based ubiquitin ligase complex coopted by Vpu to degrade cellu

145 substrate-specific adaptor for Cullin3-RING ubiquitin ligase complex (CRL3(GCL)).

146 ullin 3 function together in a Cullin 3-RING ubiquitin ligase complex (CRL3(Kelch)) to organize the r

147 We found that a modular E3 ubiquitin ligase complex CRL4(DCAF12) binds and targets

148 and Vpx engage the cullin4 (CUL4)-containing ubiquitin ligase complex (CRL4) to cause polyubiquitinat

149 ents (CUL5, RNF7 and UBE2F) of a cullin-RING ubiquitin ligase complex (CRL5) that resensitized cells

150 xcision repair (NER), associates with the E3 ubiquitin ligase complex Cul4A-DDB1.

151 ation of the FA pathway requires the FA core ubiquitin ligase complex-dependent monoubiquitination of

152 ID2 binds to the VHL ubiquitin ligase complex, displaces VHL-associated Culli

153 E3 ubiquitin ligase complexes facilitate the post-translati

154 and structural characterization of an E2-E3 ubiquitin ligase complex for LDLR degradation.

155 o a cullin 5 (Cul5) and elongin (Elo) B/C E3 ubiquitin ligase complex for proteasomal degradation.

156 protein is a substrate of the CUL4-DDB1-DET1 ubiquitin ligase complex for the proteasome degradation.

157 p1 recruits Nrf2 into the Cul3-containing E3 ubiquitin ligase complex for ubiquitin conjugation and s

158 ptor delivering PDE5 to the Cullin-3 E3 Ring ubiquitin ligase complex for ubiquitination inhibiting P

159 nus, encodes a V protein that can assemble a ubiquitin ligase complex from cellular components, leadi

160 matin-remodeling gene, and 35% had a mutated ubiquitin ligase complex gene, implicating frequent muta

161 in3 (CUL3), a core protein for the CUL3-RING ubiquitin ligase complex, has been reported to be a tumo

162 in the Kelch-like 3-Cullin 3 (KLHL3-CUL3) E3 ubiquitin ligase complex have shed light on the importan

163 However, no substrates of RhoBTB-Cul3 ubiquitin ligase complexes have been identified.

164 Cullin-dependent ubiquitin ligase complexes have been proposed to undergo

165 nes with the Gene Ontology term 'cullin-RING ubiquitin ligase complex' in the TQ-r module.

166 ncode several components involved in the SCF ubiquitin ligase complex including a viral Skp1 homolog.

167 tin with Bmi-1, a component of the hPRC1L E3 ubiquitin ligase complex, increases monoubiquityl histon

168 ile this is dependent on the DCAF1/DDB1/CUL4 ubiquitin ligase complex, interaction with human DCAF1 d

169 protein, part of the Skp1-cullin-F-box (SCF) ubiquitin ligase complex, involved in ubiquitination and

170 The Ddb1-Cul4(Cdt)(2) ubiquitin ligase complex is required for degradation of

171 y conserved Highwire (Hiw)/Drosophila Fsn E3 ubiquitin ligase complex is required for normal synaptic

172 ne-bound HMG-CoA reductase degradation (HRD) ubiquitin-ligase complex is a key player of the ER-assoc

173 main (which in mammals, interacts with an E3 ubiquitin ligase complex) is not essential for the inhib

174 reblon (CRBN), a substrate receptor of an E3 ubiquitin ligase complex, is an increasingly important s

175 ncodes a core component of a cullin-based E3 ubiquitin ligase complex, is overexpressed in breast and

176 a substrate receptor of the Cullin 4 RING E3 ubiquitin ligase complex, is the target of the immunomod

177 ity of the DDB2-DDB1-Cul4A-Roc1 (CRL4(DDB2)) ubiquitin ligase complex, leading to efficient XPC recru

178 von Hippel Lindau protein elongin B/C (VCB) ubiquitin ligase complex, leading to HIF-alpha degradati

179 CP110 is ubiquitylated by the SCF(Cyclin F) ubiquitin ligase complex, leading to its degradation.

180 We identified the CRL2(LRR1) (cullin2 RING ubiquitin ligase complex/leucine-rich repeat protein 1)

181 actions with the cellular DCAF1-DDB1-CUL4 E3 ubiquitin ligase complex limit activation of innate immu

182 hich binds to the Von-Hippel-Lindau (VHL) E3 ubiquitin ligase complex, linked to either dihydroxytest

183 The SCF(FBXO31) (Skp1-Cul1-Rbx1-FBXO31) ubiquitin ligase complex mediates genotoxic stress-induc

184 ow that ASB2, a component of the ECS(ASB) E3 ubiquitin ligase complex, mediates MLL degradation throu

185 Skp1-Cul1-F-box (SCF) E3 ubiquitin ligase complexes modulate the accumulation of

186 Thus, the SCF(FBXO17) E3 ubiquitin ligase complex negatively regulates inflammati

187 Here, we demonstrate that NSs requires E3 ubiquitin ligase complexes of the SCF (Skp1, Cul1, F-box

188 le to interact with either the DCAF1/DDB1 E3 ubiquitin ligase complex or a host factor hypothesized t

189 1 and other members of the SCF(beta-TrCP1)E3 ubiquitin ligase complex or overexpression of a dominant

190 l player in the pathway is a multisubunit E3 ubiquitin ligase complex or the FA core complex, which m

191 ate-binding component of the muscle-specific ubiquitin ligase complex Ozz-E3.

192 Here we report that the SCF(Cyclin F) ubiquitin ligase complex prevents DNA re-replication by

193 We found previously that the PALL-SCF E3-ubiquitin ligase complex promotes apoptotic cell clearan

194 We show that the CRL4(Cdt2) E3 ubiquitin ligase complex promotes PCNA monoubiqutination

195 The DDB1-Cul4A ubiquitin ligase complex promotes protein ubiquitination

196 iments substantiated that the SPOP/CUL3/Rbx1 ubiquitin ligase complex promotes SRC-3 turnover.

197 DDB1, a component of the Cul4 ubiquitin ligase complex, promotes protein ubiquitinatio

198 Among ubiquitin ligase complex proteins, Cul1, KPC1, and KPC2

199 of the Skp-Cullin-F-box-containing (SCF) E3 ubiquitin ligase complex, recognizes the NF-kappaB inhib

200 ator of the cullin ring ligase 4-cereblon E3 ubiquitin ligase complex, reduces Aiolos and Ikaros prot

201 d8 modifications from the Cullin subunits of ubiquitin ligase complexes, reducing their activity.

202 f Dishevelled demonstrates that two distinct ubiquitin ligase complexes regulate the Wnt-beta-catenin

203 her, our data indicates that a CUL3-SPOPL E3 ubiquitin ligase complex regulates endocytic trafficking

204 epeat protein2 (FBL2), a component of the E3 ubiquitin ligase complex, regulates amyloid precursor pr

205 e canonical SCF (Skp1, Cullin1, F-box, Rbx1) ubiquitin ligase complex remain unchanged and show littl

206 in (SCF) and Cul4-RING protein ligase (CRL4) ubiquitin ligase complexes, respectively.

207 F3, IRF5, and IRF7) or a component of the E3 ubiquitin ligase complex responsible for activating NF-k

208 ng protein) (SCF(Slimb/beta-TrCP)) as the E3 ubiquitin ligase complex responsible for Ex degradation.

209 We have also purified a novel Cul4A-DDB1 ubiquitin ligase complex responsible for PNKP ubiquityla

210 Loading of Merlin to the E3 ubiquitin ligase complex resulted in its polyubiquitinat

211 OP, an adaptor protein of the Cullin-RING E3 ubiquitin ligase complex, resulting in rapid ubiquitinat

212 ide evidence to support the idea that the E3 ubiquitin ligase complex RNF8-UBC13 functions independen

213 In yeast, the Asi1/Asi2/Asi3 ubiquitin ligase complex safeguards the INM proteome thr

214 rolled, partly through ubiquitination by the ubiquitin ligase complex SCF(cyclin F) during G2 and M p

215 AI2), triggering its association with the E3 ubiquitin ligase complex SCF(MAX2) and downstream target

216 CKS1 acts as a cofactor to the ubiquitin ligase complex SCF(SKP2) to promote degradatio

217 by cdk2 and on the Skp1/Cul1/F-box (SCF) E3 ubiquitin ligase complex SCF(Skp2), which targets MEF fo

218 riole overduplication and is mediated by the ubiquitin-ligase complex SCF(Slimb/betaTrCP).

219 ucine (JA-Ile) and as the component of an E3-ubiquitin ligase complex (SCF(COI1) ) that targets JAZ t

220 Here, we show that the Skp1-CUL1-Fbw7 E3 ubiquitin ligase complex (SCF(Fbw7)) targets KLF5 for ub

221 -box domain with members of a Cullin-1-based ubiquitin ligase complex (SCF): Cullin-1 and SkpA.

222 yBP/SIP or SIP), a subunit of an SCF-like E3 ubiquitin ligase complex (SCF-TBL1) formed under genotox

223 YAP1 stability through downregulation of the ubiquitin ligase complex substrate recognition factors S

224 molecular feedback loop via the COP1/SPA E3 ubiquitin ligase complex, suggesting a mechanism that ma

225 system to the substrate-specific arm of SCF ubiquitin ligase complexes, suggesting a role in SCF ass

226 s substrate adaptors in a CUL3(BOP1/BOP2) E3 ubiquitin ligase complex, targeting PIF4 proteins for ub

227 y the Keap1-Cullin3/RING box1 (Cul3-Rbx1) E3 ubiquitin ligase complex targets Nrf2 for proteasomal de

228 the substrate recognition component of an E3 ubiquitin ligase complex, targets DMRT1 for degradation

229 protein (Spop), part of the Cullin-3 (Cul3) ubiquitin ligase complex, targets Gli2 and Gli3 for degr

230 E3 ligase, assemble to form a receptor-like ubiquitin ligase complex that catalyzes the ubiquitinati

231 through which EMI1 assembles a canonical SCF ubiquitin ligase complex that constitutively targets RAD

232 r is coordinated through the SKP1-Cul1-F-box ubiquitin ligase complex that contains cullin 1 and the

233 ted by degradation mediated by a CUL-2-based ubiquitin ligase complex that contains FEM-1 as the subs

234 gradation by a SKP1-CUL1-F-box protein (SCF) ubiquitin ligase complex that contains the orphan F-box

235 s, we focused our attention on the SCF(Skp2) ubiquitin ligase complex that controls the rate of degra

236 ly encoded Vif protein, which forms a hybrid ubiquitin ligase complex that directly binds APOBEC3 enz

237 bstrate adaptor protein for a Cul3-dependent ubiquitin ligase complex that functions as a sensor for

238 in found in the Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligase complex that functions with the E2 ubiq

239 indau gene (VHL), a key component of the VHL ubiquitin ligase complex that has previously been associ

240 PHR proteins function, in part, through an ubiquitin ligase complex that includes the F-box protein

241 Mms1 is part of the E3 ubiquitin ligase complex that is linked to replication f

242 Cul3 and Rbx1 make up the ubiquitin ligase complex that is responsible for the ubi

243 ne, which encodes a core component of the E3 ubiquitin ligase complex that mediates proteasomal degra

244 We show here that Skp2, a component of a ubiquitin ligase complex that mediates the degradation o

245 teracts with beta-TrCP, a subunit of the SCF ubiquitin ligase complex that mediates the degradation o

246 FBXL5 is a subunit of an E3 ubiquitin ligase complex that mediates the stability of

247 olecule of an elongin B/elongin C/cullin/Roc ubiquitin ligase complex that mediates the ubiquitinatio

248 L3) and cullin 3 (CUL3)] form a RING-type E3-ubiquitin ligase complex that modulates WNK1 and WNK4 ab

249 b55K and E4orf6 gene products assemble an E3 ubiquitin ligase complex that promotes degradation of ce

250 pVHL forms part of the E3 ubiquitin ligase complex that regulates the degradation

251 he substrate adaptor for a SKP1-CUL1-RBX1 E3 ubiquitin ligase complex that regulates the degradation

252 Hippel Lindau protein, a component of an E3 ubiquitin ligase complex that targets hydroxylated HIF-a

253 ity for the Skp1-Cullin1-F-box protein (SCF) ubiquitin ligase complex that targets multiple oncoprote

254 in-binding protein (CacyBP), a member of the ubiquitin ligase complex that targets nonphosphorylated

255 protein that is part of the SKP-1/Cul1/F-box ubiquitin ligase complex that targets nuclear p27 among

256 ein 2 (Skp2) is the F-box component of an E3 ubiquitin ligase complex that targets p27(Kip1) and cycl

257 mutated in kidney cancer and is part of the ubiquitin ligase complex that targets prolyl hydroxylate

258 FBXO11 is a component of the SKP1-CUL1-F-box ubiquitin ligase complex that targets proteins for ubiqu

259 The VHL gene product, pVHL, is part of a ubiquitin ligase complex that targets the alpha subunits

260 he protein TAZ, an adaptor protein in the E3 ubiquitin ligase complex that targets the ciliary protei

261 ic cardiac hypertrophy by participating in a ubiquitin ligase complex that triggers degradation of ca

262 s of the SCF (Skp1-Cul1-Rbx1-F- box protein) ubiquitin ligase complexes that control the stability of

263 bined activity of two Skp-cullin-F-box (SCF) ubiquitin ligase complexes that included as substrate re

264 Mutations and deletions in components of ubiquitin ligase complexes that lead to alterations in p

265 ociated protein 2 (SKP2) as components of E3 ubiquitin ligase complexes that mediate YTHDF2 proteolys

266 ullin-RING ligases (CRLs) are a family of E3 ubiquitin ligase complexes that rely on either RING-box

267 onent of SCF (for SKP1-Cullin-F box protein) ubiquitin ligase complexes that target proteins for prot

268 propeller (KREP) domains usually found in E3 ubiquitin ligase complexes that target substrate protein

269 ons are regulated by a Cullin-3-Diablo/Kelch ubiquitin ligase complex, the activity of which is most

270 n the characterization of the mammalian gp78 ubiquitin ligase complex, the further elucidation of whi

271 ecial challenges to assembling cullin 1-RING ubiquitin ligase complexes through high affinity protein

272 interacts directly with betaTrCP in the SCF ubiquitin-ligase complex through two binding sites, whic

273 Vpr engages a DDB1- and cullin4A-containing ubiquitin-ligase complex through VprBP/DCAF1.

274 small recognition sequences of a specific E3 ubiquitin ligase complex to a known ligand for the recep

275 virus type 1 (HIV-1) Vif recruits a cellular ubiquitin ligase complex to degrade antiviral APOBEC3 en

276 and E4orf6, that together co-opt a cellular ubiquitin ligase complex to overcome host defences and p

277 om A3G-mediated restriction by forming an E3-ubiquitin ligase complex to polyubiquitinate A3G and tri

278 elegans DRE-1/FBXO11 functions in an SCF E3-ubiquitin ligase complex to regulate the transition to a

279 rate adaptor protein for a Cul3-dependent E3 ubiquitin ligase complex to repress steady-state levels

280 ylate p16, priming the BMI1-containing PRC1L ubiquitin ligase complex to silence p16.

281 iral infectivity factor (Vif) form a CRL5 E3 ubiquitin ligase complex to suppress virus restriction b

282 lentivirus HIV-1 and SIV Vif proteins form a ubiquitin ligase complex to target host antiviral APOBEC

283 ates germination by causing the SCF(SLY1) E3 ubiquitin ligase complex to trigger ubiquitination and d

284 scaffold proteins that assemble multisubunit ubiquitin ligase complexes to confer substrate specifici

285 munodeficiency virus (SIV), and BIV all form ubiquitin ligase complexes to target host antiviral APOB

286 ASB2alpha, the specificity subunit of an E3-ubiquitin ligase complex, triggers acute proteasomal deg

287 are controlled by a cullin 1-containing E(3) ubiquitin ligase complex upon dual phosphorylation by ca

288 A component of the E3 ubiquitin ligase complex, von Hippel-Lindau (VHL) facili

289 chemical inhibitors of proteins in the Hrd1 ubiquitin ligase complex, we demonstrate that the Sel1L,

290 APC/C is an E3 ubiquitin ligase complex well characterized for its role

291 L3) and Cullin 3 (CUL3), components of an E3 ubiquitin ligase complex, were found to cause PHAII, sug

292 3 in the Kelch-like homologue 9-Cullin 3-E3 ubiquitin ligase complex, which is involved in ubiquitin

293 GENIC 1-SUPPRESSOR OF PHYA-105 1 (COP1-SPA1) ubiquitin ligase complex, which promotes turnover of CO.

294 ssociation of NIK with the cIAP1-cIAP2-TRAF2 ubiquitin ligase complex, which resulted in NIK stabiliz

295 , a putative adaptor for the Cullin-3 (Cul3) ubiquitin ligase complex, which together with Cul3 is es

296 ession of Skp2 and Cks1, subunits of the SCF ubiquitin ligase complex, which ubiquitinates p27(Kip1)

297 on subunits of SCF (Skp1-Cul1-F-box protein) ubiquitin ligase complexes, which mediate the timely pro

298 a mechanism whereby Keap1, as part of an E3 ubiquitin ligase complex with Cul3 and Rbx1, facilitates

299 radation by linking the Elongin-BC-dependent ubiquitin ligase complex with the APOBEC3 proteins.

300 Caenorhabditis elegans RPM-1 functions in a ubiquitin ligase complex with the F-box protein FSN-1 an