ライフサイエンスコーパス: ubiquitin-mediated

1 positively controls NF-kappaB signalling via ubiquitin-mediated activation of DREDD.

2 The concept of ubiquitin-mediated activation of protein kinases is supp

3 e, we show that Notch activation accelerates ubiquitin-mediated and mitogen-activated protein kinase

4 Here we show that parkin has a role in ubiquitin-mediated autophagy of M. tuberculosis.

5 on system allows cytosolic components of the ubiquitin-mediated autophagy pathway access to phagosoma

6 y mRNA profiling, and included activation of ubiquitin-mediated autophagy, an evolutionarily ancient

7 by inhibiting WNT/beta-catenin signaling via ubiquitin-mediated beta-catenin degradation.

8 ation, indicating that HSP90 acts to control ubiquitin-mediated catabolism of the TSSKs.

9 s ubiquitination at Lys 147 and inhibits the ubiquitin-mediated CDK6 degradation.

10 Using the fluorescent ubiquitin-mediated cell cycle indicator (FUCCI), we foun

11 h CK1 as an integral component of a mitotic, ubiquitin-mediated checkpoint pathway.

12 Mechanistic experiments validated ubiquitin-mediated control of PPP2R5e stability through

13 lso define a novel link between PTEN and the ubiquitin-mediated control of protein stability.

14 tions in ultraviolet radiation (UVR)-induced ubiquitin-mediated CSB degradation.

15 in stability may occur in part by preventing ubiquitin-mediated degradation and promoting beta1-integ

16 slocase uses SUMO as a cue to save Top2 from ubiquitin-mediated degradation and to minimize DNA break

17 ranscription, NFX1-91, which is targeted for ubiquitin-mediated degradation by HPV type 16 (HPV16) E6

18 ously demonstrated that Nrf2 is targeted for ubiquitin-mediated degradation by Keap1 in a redox-sensi

19 these cellular proteins, resulting in their ubiquitin-mediated degradation by the proteasome.

20 teosome, suggesting that BOS1 is a target of ubiquitin-mediated degradation by the proteosome.

21 egulates PML protein levels by promoting its ubiquitin-mediated degradation dependent on direct phosp

22 Phosphorylation renders Cdt1 resistant to ubiquitin-mediated degradation during S phase and after

23 ein ligase RING finger protein 4 resulted in ubiquitin-mediated degradation in a 26S-proteosome-depen

24 egulates osteogenesis by targeting Runx2 for ubiquitin-mediated degradation in a GSK3beta-dependent m

25 ligase complex (SCF(Fbw7)) targets KLF5 for ubiquitin-mediated degradation in a GSK3beta-mediated KL

26 matopoiesis, and oxygen (O(2)) delivery, for ubiquitin-mediated degradation in an O(2)-dependent mann

27 he SFK LynA is uniquely susceptible to rapid ubiquitin-mediated degradation in macrophages, functioni

28 eletal muscle myosin as a specific target of ubiquitin-mediated degradation in muscle atrophy.

29 eap1, which targets Nrf2 for redox-sensitive ubiquitin-mediated degradation in the cytoplasm and expo

30 1 alleles refractory to phosphorylation- and ubiquitin-mediated degradation increase the frequency of

31 Inactivation of CDC25A by ubiquitin-mediated degradation is a major mechanism of D

32 at the tight control of mDia2 expression and ubiquitin-mediated degradation is essential for the comp

33 3A suppresses neuronal hyperexcitability via ubiquitin-mediated degradation of calcium- and voltage-d

34 Our results suggest that ubiquitin-mediated degradation of CDC-25.1 is a rate-det

35 armacologic inhibition of HSP90 leads to the ubiquitin-mediated degradation of clients, particularly

36 In the present study, we report that ubiquitin-mediated degradation of dMyc, the Drosophila h

37 AIP2 interacts with and promotes ubiquitin-mediated degradation of EGR2, a zinc finger tr

38 rane, Crb promotes phosphorylation-dependent ubiquitin-mediated degradation of Ex.

39 tors: they promote ER retention of SCAP, but ubiquitin-mediated degradation of HMGR.

40 ntration of hSnm1B on telomeres by promoting ubiquitin-mediated degradation of hSnm1B that is not loc

41 hermore, MyoD has been shown to modulate the ubiquitin-mediated degradation of Id1 and E2A proteins,

42 ining F-box protein that likely mediates the ubiquitin-mediated degradation of important sex-determin

43 e with intestinal epithelial cells modulates ubiquitin-mediated degradation of important signaling in

44 al processes and plays a central role in the ubiquitin-mediated degradation of misfolded proteins.

45 This, in turn, facilitates anaphase-onset by ubiquitin-mediated degradation of mitotic substrates.

46 bit heat shock protein 90 (Hsp90), promoting ubiquitin-mediated degradation of oncogenic kinases that

47 tion, ECA tissue lysates show a high rate of ubiquitin-mediated degradation of p27 compared with norm

48 essor p53, which is thought to arise through ubiquitin-mediated degradation of p53 and involve a tern

49 d CUL4A-PCNA interaction and CUL4A-dependent ubiquitin-mediated degradation of PCNA.

50 osphorylation of STAT3 and EGFR and promoted ubiquitin-mediated degradation of PD-L1.

51 Mechanistically, SUMOylation promoted ubiquitin-mediated degradation of PIM1 via recruitment o

52 we identify an E3 ligase that catalyzes the ubiquitin-mediated degradation of PKC.

53 the ubiquitin E3 ligase RNF4 leading to the ubiquitin-mediated degradation of PML.

54 point, which delays anaphase by blocking the ubiquitin-mediated degradation of securin/Pds1p by APCCd

55 state causes nuclear exclusion and cytosolic ubiquitin-mediated degradation of SIRT1.

56 he regulatory function of RNF4 appears to be ubiquitin-mediated degradation of sumoylated cellular pr

57 ced by local caspase activation triggered by ubiquitin-mediated degradation of the caspase inhibitor

58 ue of Blood, Saur and colleagues report that ubiquitin-mediated degradation of the Mpl receptor const

59 Cosmc prevents the aggregation and ubiquitin-mediated degradation of the T-synthase.

60 These findings indicate that ubiquitin-mediated degradation of the ZIP4 protein is cr

61 in plants and metazoan animals, and include ubiquitin-mediated degradation of transcription factors

62 induce rapid phosphorylation and consequent ubiquitin-mediated degradation of, transcription factors

63 cancers, the tumor suppressor PML undergoes ubiquitin-mediated degradation primed by CK2 phosphoryla

64 operties of Fbs1, which functions within the ubiquitin-mediated degradation system to recognize the c

65 sphorylation by GSK3beta are mediated by its ubiquitin-mediated degradation through E3 ubiquitin liga

66 proteasome complex binds and targets p53 for ubiquitin-mediated degradation via gankyrin-MDM2/HDM2 pa

67 a ubiquitin ligase that targets proteins for ubiquitin-mediated degradation, and Cul4A-haploinsuffici

68 rotubule-associated protein tau prevents its ubiquitin-mediated degradation, resulting in "tau tangle

69 ated Smad (R-Smad) proteins are regulated by ubiquitin-mediated degradation, yet the precise control

70 7) interacts with HsSAS-6 and targets it for ubiquitin-mediated degradation.

71 ciated with embryogenesis/angiogenesis), for ubiquitin-mediated degradation.

72 criptional activators and protooncogenes for ubiquitin-mediated degradation.

73 ation of PLCgamma1 and mostly refrained from ubiquitin-mediated degradation.

74 bunit of protein phosphatase 2A (PP2A-C) for ubiquitin-mediated degradation.

75 tes with COP1 and is involved in 14-3-3sigma ubiquitin-mediated degradation.

76 at targets the hypoxia-inducible factors for ubiquitin-mediated degradation.

77 inylating GLS and thereby protecting it from ubiquitin-mediated degradation.

78 lates the WEE1 protein and rescues WEE1 from ubiquitin-mediated degradation.

79 ation and protects human EST1B (hEST1B) from ubiquitin-mediated degradation.

80 c-Myc, and in this way, PP2A enhances c-Myc ubiquitin-mediated degradation.

81 ls p27(Kip1) stability by targeting Skp2 for ubiquitin-mediated degradation.

82 or Hsl7, and is hyperphosphorylated prior to ubiquitin-mediated degradation.

83 d to the neck and hyperphosphorylated before ubiquitin-mediated degradation.

84 rocesses by recruiting specific proteins for ubiquitin-mediated degradation.

85 ess response genes and stabilize p53 against ubiquitin-mediated degradation.

86 ase, which specifically targets proteins for ubiquitin-mediated degradation.

87 interacts with RUNX1 and prevents RUNX1 from ubiquitin-mediated degradation.

88 n in IFN-gamma-activated macrophages through ubiquitin-mediated delivery of class II to lysosomes, es

89 ed degradation (ERAD) is responsible for the ubiquitin-mediated destruction of both misfolded and nor

90 Ume6p repression is relieved by ubiquitin-mediated destruction that is stimulated by Gcn

91 r (GMR) adaptor protein that targets Src for ubiquitin-mediated destruction upon GM-CSF stimulation a

92 sociated herpesvirus targets VE-cadherin for ubiquitin-mediated destruction, thus disturbing EC adhes

93 eins required for cellular proliferation for ubiquitin-mediated destruction.

94 st that modulation of regulators involved in ubiquitin-mediated disposal of RAGE might serve as uniqu

95 ependency of aneuploid cells on a pathway of ubiquitin-mediated endocytic recycling of nutrient trans

96 Ubiquitin-mediated endocytosis and degradation of glutam

97 we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and degradation, and that

98 the glucose sensors are inactivated through ubiquitin-mediated endocytosis and degraded in the prese

99 Ubiquitin-mediated endocytosis and post-endocytic traffi

100 Ubiquitin-mediated endocytosis plays a crucial role in t

101 of TORC1, underscoring how TORC1 coordinates ubiquitin-mediated endocytosis with protein synthesis an

102 plasma membrane (PM) proteins by regulating ubiquitin-mediated endocytosis.

103 ing disorder, we establish the importance of ubiquitin-mediated endolysosomal trafficking at the syna

104 The yeast Hmg2p isozyme is subject to ubiquitin-mediated endoplasmic reticulum degradation by

105 the downstream ICL repair steps initiated by ubiquitin-mediated FA pathway activation.

106 tination and lysosomal localization by using ubiquitin-mediated fluorescence complementation (UbFC) i

107 itinated proteins in living cells designated ubiquitin-mediated fluorescence complementation (UbFC).

108 s in understanding the role and mechanism of ubiquitin-mediated IKK activation, and raise some questi

109 Ubiquitin-mediated inactivation of caspases has long bee

110 Furthermore, an inhibitor of ubiquitin-mediated interactions blocks cleavage, demonst

111 FR) is targeted for lysosomal degradation by ubiquitin-mediated interactions with the ESCRTs (endosom

112 g only lysine-27, but no other single-lysine ubiquitin, mediated Jun ubiquitination, albeit at lower

113 Second, it targets PKAC for rapid ubiquitin-mediated lysosomal degradation, a pathway usua

114 at Ku80 is degraded in response to DSBs in a ubiquitin-mediated manner.

115 y E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediated mechanism for regulation of Clec9A, r

116 teolytically released from the membrane by a ubiquitin-mediated mechanism.

117 g evidence also supports a critical role for ubiquitin-mediated modifications in dynamically regulati

118 Phosphorylation and ubiquitin-mediated modulation of Myc protein influence s

119 URF3 can function as ubiquitin E3 ligases in ubiquitin-mediated muscle protein turnover.

120 instability was independent of a functional ubiquitin-mediated pathway, suggesting that pUL21a under

121 rf4 is to regulate Erf2 stability through an ubiquitin-mediated pathway.

122 an undergo degradation by PRAJA, through the ubiquitin-mediated pathway.

123 togen-activated protein kinase-dependent and ubiquitin-mediated pathway.

124 sir4 and spt16 proteins for degradation by a ubiquitin-mediated pathway.

125 stability in vivo in the absence of specific ubiquitin-mediated pathways in human cells.

126 ophila, have provided mounting evidence that ubiquitin-mediated pathways play important roles in cont

127 athways enriched in male germ cells included ubiquitin-mediated pathways, pathways involved in chroma

128 A-mediated posttranscriptional pathway and a ubiquitin-mediated posttranslational regulatory pathway.

129 However, the mechanisms regulating these ubiquitin-mediated processes are unknown.

130 pression of the UBAc, inhibited a variety of ubiquitin-mediated processes such as degradation of ubiq

131 wed that it is unstable and is regulated via ubiquitin-mediated proteasomal degradation at the base o

132 dls and, on the other hand, targets Dcp2 for ubiquitin-mediated proteasomal degradation in the absenc

133 geting effect, suggesting the involvement of ubiquitin-mediated proteasomal degradation in the proces

134 rolyl hydroxylase 3 and Spry2 (Sprouty2) for ubiquitin-mediated proteasomal degradation is attenuated

135 Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated

136 This leads to the ubiquitin-mediated proteasomal degradation of DELLAs and

137 The IKKbeta kinase promotes ubiquitin-mediated proteasomal degradation of DeltaNp63a

138 SUMO modification of FoxM1b facilitates the ubiquitin-mediated proteasomal degradation of FoxM1b.

139 This results in ubiquitin-mediated proteasomal degradation of mitofusin

140 g regions, and that it binds to and promotes ubiquitin-mediated proteasomal degradation of Slug.

141 or this disease as it induces SUMO-dependent ubiquitin-mediated proteasomal degradation of the PML-RA

142 Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and purified

143 The resulting free p11 undergoes ubiquitin-mediated proteasomal degradation, thus prevent

144 late SKP2, which then down-regulates p21 via ubiquitin-mediated proteasomal degradation.

145 that the Bfl-1 protein is also regulated by ubiquitin-mediated proteasomal degradation.

146 th a half-life of 60 min caused by its rapid ubiquitin-mediated proteasomal degradation.

147 erves as a signal for retrotranslocation and ubiquitin-mediated proteasomal degradation.

148 ibitor, IkappaBalpha, allowing it to undergo ubiquitin-mediated proteasomal degradation.

149 acts directly with SOX9 and prevents it from ubiquitin-mediated proteasomal degradation.

150 tivity is regulated by DNA binding-dependent ubiquitin-mediated proteasomal degradation.

151 n target a handful of signaling proteins for ubiquitin-mediated proteasomal destruction or functional

152 The ubiquitin-mediated proteasomal pathway regulates diverse

153 thereby facilitating its degradation via the ubiquitin-mediated proteasomal pathway.

154 LPS exposure reduces the ubiquitin-mediated proteasomal processing of NALP3 by in

155 nst cathepsin B, reactive oxygen species, or ubiquitin-mediated proteasome activity fail to suppress

156 of cellular recycling pathways including the ubiquitin-mediated proteasome and autophagy, with concur

157 d adhesion probably occur through preventing ubiquitin-mediated proteasome degradation of alpha5beta1

158 We found that the ubiquitin-mediated proteasome degradation pathway is the

159 cerative colitis and controls as a result of ubiquitin-mediated proteasome degradation.

160 Snail, provoking its cytoplasmic export for ubiquitin-mediated proteasome degradation.

161 apidly degraded under normoxic conditions by ubiquitin-mediated proteasome pathway controlled by the

162 ns that modulate gene expression through the ubiquitin-mediated proteasome system.

163 Ubiquitin mediated protein degradation is crucial for re

164 ht to function as a typical F-box protein in ubiquitin-mediated protein degradation and, along with S

165 phosphotransfer relay, an EIN2-based unit, a ubiquitin-mediated protein degradation component, and a

166 hat dynamic regulation of taste receptors by ubiquitin-mediated protein degradation comprises an impo

167 Thus, subcellular regulation of ubiquitin-mediated protein degradation contributes to pr

168 Ubiquitin-mediated protein degradation has been proposed

169 of other proteins, their individual roles in ubiquitin-mediated protein degradation has proven diffic

170 Recent studies have implicated ubiquitin-mediated protein degradation in synaptic devel

171 suppressed by mutations in ORE9, implicating ubiquitin-mediated protein degradation in the regulation

172 Ubiquitin-mediated protein degradation is a common featu

173 Controlled ubiquitin-mediated protein degradation is essential for

174 Timely ubiquitin-mediated protein degradation is fundamental to

175 se studies are the first to demonstrate that ubiquitin-mediated protein degradation is important for

176 stabilization of c-Myc by attenuation of its ubiquitin-mediated protein degradation mechanism.

177 s a prototype of viral hijacking of both the ubiquitin-mediated protein degradation pathway and the p

178 Neddylation has an important role in ubiquitin-mediated protein degradation through modificat

179 are regulated in many ways, one of which is ubiquitin-mediated protein degradation.

180 ulates F box proteins, which are involved in ubiquitin-mediated protein degradation.

181 quitin is a potent and specific inhibitor of ubiquitin-mediated protein degradation.

182 ne (K) 391, which protects HIF1alpha against ubiquitin-mediated protein degradation.

183 t for exploring the pathways associated with ubiquitin-mediated protein mishandling in FTD-U and ALS.

184 Ubiquitin-mediated protein modification plays a key role

185 viously unrecognized level of specificity in ubiquitin-mediated protein sorting.

186 These results suggest that ubiquitin-mediated protein turnover and MURF2 in particu

187 The critical roles played by ubiquitin-mediated protein turnover in cell cycle regula

188 an antagonistic role of ISG15 in regulating ubiquitin-mediated protein turnover.

189 Degradation of Emi2 via ubiquitin-mediated proteolysis after fertilization requi

190 otein quality-control (PQC) pathways such as ubiquitin-mediated proteolysis and autophagy.

191 findings indicate a functional link between ubiquitin-mediated proteolysis and cellular resistance t

192 ults suggest enrichment of genes involved in ubiquitin-mediated proteolysis and of genes expressed in

193 e show here that Dia2 is itself targeted for ubiquitin-mediated proteolysis and that activation of th

194 in D1 contributes to cell cycle progression, ubiquitin-mediated proteolysis buffers this accumulation

195 Not only does ubiquitin-mediated proteolysis constitute a critical com

196 Screening a variety of mutants involved in ubiquitin-mediated proteolysis demonstrated an important

197 we show that Cdt1 is completely degraded by ubiquitin-mediated proteolysis during the course of the

198 Ubiquitin-mediated proteolysis has an important role in

199 The degradation of proteins through ubiquitin-mediated proteolysis has been previously shown

200 of an ancient pathway from which eukaryotic ubiquitin-mediated proteolysis has evolved.

201 Ubiquitin-mediated proteolysis has previously been shown

202 cycle control and implicate critical role of ubiquitin-mediated proteolysis in ciliary disassembly.

203 he nucleus, are predominantly turned over by ubiquitin-mediated proteolysis in late mitosis/early G1.

204 eased osteoblast differentiation and reduced ubiquitin-mediated proteolysis in marrow only).

205 ntified both positive and negative roles for ubiquitin-mediated proteolysis in the regulation of long

206 Ubiquitin-mediated proteolysis is a key regulatory proce

207 ia protein turnover in other processes where ubiquitin-mediated proteolysis is an essential component

208 Ubiquitin-mediated proteolysis is critical for the alter

209 uppressor p53 is maintained at low levels by ubiquitin-mediated proteolysis mainly through Mdm2.

210 Mitochondrial dysfunction, impaired ubiquitin-mediated proteolysis of alpha-synuclein, and E

211 This facilitates beta-TrCP binding and ubiquitin-mediated proteolysis of Cdc25A throughout inte

212 hroughout evolution in eukaryotes, including ubiquitin-mediated proteolysis of cell cycle regulators

213 The ubiquitin-mediated proteolysis of cyclin E plays a centr

214 IAP-like RING domain, can contribute to the ubiquitin-mediated proteolysis of DED caspases.

215 of the proteasome, leading to the idea that ubiquitin-mediated proteolysis of Gcn4 is required for i

216 related multisubunit enzymes central to the ubiquitin-mediated proteolysis of many important biologi

217 ase-associated protein 2 (Skp2) that directs ubiquitin-mediated proteolysis of p27(Kip1).

218 Ubiquitin-mediated proteolysis of p27Kip1 is an importan

219 Transcriptional arrest can trigger ubiquitin-mediated proteolysis of RNA polymerase II (RNA

220 Accumulation of SUMO chains in vivo leads to ubiquitin-mediated proteolysis of RNF4.

221 The ubiquitin-mediated proteolysis of the Cdk2 inhibitor p27

222 ome (APC/C) is an E3 ubiquitin ligase in the ubiquitin-mediated proteolysis pathway (UMP).

223 nalyses revealed FoxO-dependent increases in ubiquitin-mediated proteolysis pathways in STZ-Diabetes,

224 Ubiquitin-mediated proteolysis plays a central role in c

225 Ubiquitin-mediated proteolysis plays a key role in many

226 Ubiquitin-mediated proteolysis regulates all aspects of

227 cate that Cul4A ubiquitin ligases target for ubiquitin-mediated proteolysis regulators of cell-cycle

228 tion between the transcription machinery and ubiquitin-mediated proteolysis that is developmentally r

229 , including autophagy, which cooperated with ubiquitin-mediated proteolysis to degrade free alpha-glo

230 Here we show that REST is regulated by ubiquitin-mediated proteolysis, and use an RNA interfere

231 s are proposed to target SUMO conjugates for ubiquitin-mediated proteolysis, but the only in vivo sub

232 ox protein, which binds to the substrate for ubiquitin-mediated proteolysis, is involved in maintenan

233 ses calcineurin by targeting calcineurin for ubiquitin-mediated proteolysis, leading to inhibition of

234 modifications and the N-end rule pathway of ubiquitin-mediated proteolysis, providing a platform for

235 stem-cell (HSC) regulators are controlled by ubiquitin-mediated proteolysis, so the ubiquitin pathway

236 sensed by the Cys-Arg/N-end rule pathway of ubiquitin-mediated proteolysis, through oxygen-dependent

237 ependent phosphorylation and is targeted for ubiquitin-mediated proteolysis, thus providing a mechani

238 ociated protein-2 (SKP2) plays a key role in ubiquitin-mediated proteolysis, which results in the pro

239 ion was partially prevented by inhibitors of ubiquitin-mediated proteolysis.

240 es centriole duplication and is regulated by ubiquitin-mediated proteolysis.

241 e PCO branch of the PRT6 N-degron pathway of ubiquitin-mediated proteolysis.

242 6AP) and target the tumor suppressor p53 for ubiquitin-mediated proteolysis.

243 After mitosis, APC/C(Cdh1) targets Cik1 for ubiquitin-mediated proteolysis.

244 oteins revealed several proteins involved in ubiquitin-mediated proteolysis.

245 rt because active Src protein is degraded by ubiquitin-mediated proteolysis.

246 tin ligase that regulates PGC-1alpha through ubiquitin-mediated proteolysis.

247 for the extreme N terminus of the protein in ubiquitin-mediated proteolysis.

248 nd master regulator of sex determination, by ubiquitin-mediated proteolysis.

249 . elegans sex determination is controlled by ubiquitin-mediated proteolysis.

250 targeting the Cdc25A protein phosphatase for ubiquitin-mediated proteolysis.

251 self regulated throughout the cell cycle via ubiquitin-mediated proteolysis.

252 et the replication licensing factor Cdt1 for ubiquitin-mediated proteolysis.

253 involves their release from the membrane by ubiquitin-mediated proteolysis.

254 are also components of a complex involved in ubiquitin-mediated proteolysis.

255 sis in Xenopus extracts, and is targeted for ubiquitin-mediated proteolysis.

256 that inhibition of Nrf2 may also depend upon ubiquitin-mediated proteolysis.

257 AA) family of transcriptional regulators for ubiquitin-mediated proteolysis.

258 e checkpoint, processive DNA replication, or ubiquitin-mediated proteolysis.

259 whose expression levels can be regulated by ubiquitin-mediated proteolysis.

260 in destruction via the N-end rule pathway of ubiquitin-mediated proteolysis.

261 et the key effector protein beta-catenin for ubiquitin-mediated proteolysis.

262 a HPV, which inactivate p53 by targeting its ubiquitin-mediated proteolysis.

263 hydrogen peroxide, where it is destroyed by ubiquitin-mediated proteolysis.

264 1 is regulated throughout the cell cycle via ubiquitin-mediated proteolysis.

265 ction for the lncRNA HOTAIR as an inducer of ubiquitin-mediated proteolysis.

266 factor Gal4 undergoes two distinct modes of ubiquitin-mediated proteolysis: one that occurs independ

267 biquitinates dTRAF2 and prevents dTRAF2 from ubiquitin-mediated proteolytic degradation.

268 he cell's 'protein-degrading machine' in the ubiquitin-mediated proteolytic pathway for regulated pro

269 , through a degron near its N terminus, by 2 ubiquitin-mediated proteolytic systems, the Ubr1/Rad6-de

270 evels on days 0-2 of differentiation undergo ubiquitin-mediated proteosomal degradation on days 2.5-3

271 a heat shock cognate (HSC70) clients using a ubiquitin-mediated proximity tagging strategy and show t

272 al PTEN expression through the inhibition of ubiquitin-mediated PTEN degradation.

273 eals both the substrate and the mechanism of ubiquitin-mediated regulation of Golgi membrane dynamics

274 ification, and underscores the importance of ubiquitin-mediated regulation to refine signaling cascad

275 cilitate the search for yet-to-be discovered ubiquitin-mediated regulatory mechanisms in mTOR signali

276 opoisomerase II and axis component Red1) and ubiquitin-mediated removal of SUMOylated proteins are al

277 ides unique insights into the novel types of ubiquitin-mediated signal-activation mechanism, and prev

278 Ubiquitin mediated signaling contributes critically to h

279 mes (DUBs) are proteases that can antagonize ubiquitin-mediated signaling by disassembling ubiquitin-

280 us cellular processes are regulated by (poly)ubiquitin-mediated signaling events, which involve a cov

281 These studies define an atypical ubiquitin-mediated signaling pathway used by a subset of

282 resome formation and further suggest a novel ubiquitin-mediated signaling pathway, where the exposure

283 o our current appreciation of the breadth of ubiquitin-mediated signaling.

284 Inhibition of ubiquitin-mediated Smad1 and Runx2 degradation in osteob

285 UNC-108/Rab2 was not required for ubiquitin-mediated sorting of GLR-1::GFP into the multiv

286 tivity leading to respective changes in both ubiquitin-mediated sorting of the manganese transporter

287 Our finding that distinct ubiquitin-mediated sorting steps employ unique trans-act

288 e define unique requirements for each of the ubiquitin-mediated sorting steps involved in delivery of

289 Parkin conferred this effect, in part, via ubiquitin-mediated stabilization of the lipid transporte

290 This ubiquitin-mediated switch in EGFR trafficking is a uniqu

291 regions previously shown to be important for ubiquitin-mediated targeting and proteasomal destruction

292 Ubiquitin-mediated targeting of intracellular bacteria t

293 the endoplasmic reticulum (ER) membrane, and ubiquitin-mediated targeting to the proteasome for degra

294 is an unstable nuclear protein sensitive to ubiquitin-mediated targeting to the proteasome, NT-PGC-1

295 -DDB1-VprBP E3 ligase complex for subsequent ubiquitin-mediated TERT protein degradation.

296 unterpart Sel-10 have been implicated in the ubiquitin-mediated turnover of cyclin E as well as the N

297 KEL-8 is required for the ubiquitin-mediated turnover of GLR-1 subunits, and kel-8

298 r, p27(Kip1) protein levels are regulated by ubiquitin-mediated turnover, leading to destruction by t

299 tion via a pathway distinct from its typical ubiquitin-mediated turnover.

300 reas complete USP7 deficiency leads to rapid ubiquitin-mediated XPC degradation upon UV irradiation.