ライフサイエンスコーパス: ubiquitin-specific protease

1 lation apparatus, with cyclin D3, and with a ubiquitin-specific protease.

2 ses the proportion of ND10 which contain the ubiquitin-specific protease.

3 lent adduct with the active site cysteine of ubiquitin-specific proteases.

4 of GPCRs by ubiquitin ligases and removed by ubiquitin-specific proteases.

5 Here, we show that the DUB ubiquitin specific protease 1 (USP1) deubiquitinates the

6 The ubiquitin-specific protease 1 (USP1) is a known critical

7 Ubiquitin-specific protease 1 (USP1) is one such target,

8 Ubiquitin-specific protease 1 (USP1), a nucleus-localize

9 stitutively antagonized by the action of the ubiquitin-specific protease 1 (USP1).

10 The deubiquitinating enzyme USP1 (ubiquitin-specific protease 1), in association with UAF1

11 ity, as an interacting partner for the USP1 (ubiquitin-specific protease 1)-UAF1 (USP1-associated fac

12 regulates p53 expression by interacting with ubiquitin-specific protease 10 (USP10), a deubiquitinati

13 irway epithelial cells, we demonstrated that Ubiquitin Specific Protease-10 (USP10) is located in ear

14 The aberrant expression of ubiquitin-specific protease 11 (USP11) is believed to be

15 We observed that the ubiquitin-specific protease 11 (USP11) is highly express

16 Here, we show that the deubiquitinase ubiquitin-specific protease 11 (USP11) restricts autopha

17 h, we identified the deubiquitinating enzyme ubiquitin-specific protease 11 (USP11), a known DDR-comp

18 ing enzymes that regulate AR; in that screen ubiquitin-specific protease 12 (Usp12) was identified as

19 Two deubiquitylating enzymes, UBIQUITIN-SPECIFIC PROTEASE 12 and 13 (UBP12 and UBP13),

20 Here, we show that UBP12/UBP13 (ubiquitin-specific protease 12/13) antagonize the action

21 fication of a deubiquitinating enzyme, named ubiquitin-specific protease 13 (USP13) that appears to b

22 regulating receptor fate, we report that the ubiquitin-specific protease 14 (USP14) interacts with th

23 Ubiquitin-specific protease 14 (USP14) is a component of

24 The axJ gene encodes ubiquitin-specific protease 14 (Usp14), a deubiquitinati

25 this study, we investigated the role of the ubiquitin-specific protease 14 (Usp14), a proteasome-ass

26 axia (ax(J)) mice have reduced expression of ubiquitin-specific protease 14 (Usp14), resulting in sev

27 om substrates by the deubiquitylating enzyme ubiquitin-specific protease 14 (USP14), which reversibly

28 Here we show that ax encodes ubiquitin-specific protease 14 (Usp14).

29 LX1570 binds to and inhibits the activity of ubiquitin-specific protease-14 (USP14) in vitro, with co

30 first time, evidence that the deubiquitinase ubiquitin-specific protease-14 (Usp14), a major regulato

31 ssful capture of the TRIM-25-associated DUB, ubiquitin specific protease 15, demonstrated the versa-t

32 al development and virulence, especially the ubiquitin-specific protease 15 (Ubp15).

33 The induction of ubiquitin-specific protease 15 was dependent on calcium

34 ted induction of the deubiquitinating enzyme ubiquitin-specific protease 15 was observed, which is kn

35 the murine USP18 (Ubp43) gene and the human ubiquitin specific protease 18 (USP18) gene and encodes

36 Here we show that depletion of ubiquitin specific protease 18 (USP18), a negative regul

37 Ubiquitin-specific protease 18 (USP18) is a multifunctio

38 The negative feedback regulator ubiquitin-specific protease 18 (USP18) potently interfer

39 fied a member of the deubiquitinases family, ubiquitin-specific protease 18 (USP18), as a novel negat

40 d genes included IFN-induced 15-kDa protein, ubiquitin-specific protease 18, glucocorticoid attenuate

41 Here, we identified ubiquitin-specific protease 19 (USP19) as a positive reg

42 Here we show that the ubiquitin-specific protease-19 (USP19) interacts with co

43 genetic screening approach, we identify the ubiquitin-specific protease 2 (USP2) as a post-transcrip

44 In this study, we identified ubiquitin-specific protease 2 (USP2) as an inducible reg

45 inhibitors of a human deubiquitinase (DUB), ubiquitin-specific protease 2 (USP2).

46 We report that ubiquitin-specific protease 20 (USP20) deubiquitinates a

47 be impeded by deubiquitinating enzymes like ubiquitin-specific protease 20 (USP20), which can revers

48 1-interacting protein 5 via association with ubiquitin specific protease 21 (USP21) debiquitinase.

49 Ubiquitin-specific protease 21 (USP21), one of four majo

50 report that the histone ubiquitin hydrolase ubiquitin-specific protease 22 (USP22) is a critical epi

51 The Ubiquitin-Specific Protease 22 (USP22) is a deubiquitina

52 d, we identified the deubiquitinating enzyme ubiquitin-specific protease 22 (USP22), a component of t

53 cal studies reveal that depletion of Gcn5 or ubiquitin-specific protease 22 (Usp22), which is another

54 ncreasing evidence links deregulation of the ubiquitin-specific proteases 22 (USP22) deubitiquitylase

55 ore significant in the linked subset and the ubiquitin-specific protease 24 gene (USP24).

56 Here, we identify ubiquitin-specific protease 25 (USP25) as a positive reg

57 lines and Usp25 knockout mice, we show that ubiquitin-specific protease 25 (USP25) engages in multip

58 findings have revealed an essential role for ubiquitin-specific protease 26 in cellular reprogramming

59 Here we report for the first time that ubiquitin-specific protease 26 negatively regulates soma

60 The ubiquitin-specific protease 28 (USP28) has been implicat

61 e formation of p53-binding protein 1 (53BP1)-ubiquitin-specific protease 28 (USP28)-p53 protein compl

62 HIF-1alpha degradation can be antagonized by ubiquitin-specific protease 28 (USP28).

63 USP28 (ubiquitin-specific protease 28) is a deubiquitinating en

64 reased p53 levels in two ways: by decreasing ubiquitin specific protease 2a (USP2a) expression leadin

65 emonstrated that the deubiquitinating enzyme ubiquitin-specific protease 2a (USP2a) has oncogenic pro

66 It has previously been shown that ubiquitin-specific protease 2a (USP2a) is a regulator of

67 Deubiquitination by ubiquitin-specific protease 2a and AKT-mediated phosphor

68 We identified ubiquitin-specific protease 30 (USP30), a mitochondrial

69 we reveal the deubiquitylating enzyme (DUB) ubiquitin-specific protease 32 (USP32) as a powerful pla

70 daptor molecule-binding protein (STAMBP) and ubiquitin-specific protease 33 (USP33) as cognate deubiq

71 e discovery that the deubiquitinating enzyme ubiquitin-specific protease 33 (USP33) binds beta-arrest

72 We show that ubiquitin-specific protease 33 (USP33)/VDU1, originally

73 Conversely, siRNA knockdown of ubiquitin-specific protease-34 expression decreased thro

74 ction two DUBs including cylindromatosis and ubiquitin-specific protease-34 that specifically regulat

75 Among them, the ubiquitin-specific protease 36 (USP36) has been implicat

76 dentified the deubiquitinating enzyme USP44 (ubiquitin-specific protease 44) as a critical regulator

77 We have previously shown that the DUB ubiquitin-specific protease 46 (USP-46) removes ubiquiti

78 is study identifies a novel role for the DUB ubiquitin-specific protease-46 (USP-46) and its associat

79 re, we show that the deubiquitinating enzyme ubiquitin-specific protease-46 (USP-46) regulates the ab

80 The conserved deubiquitinating enzyme (DUB) ubiquitin-specific protease-46 (USP-46) removes ubiquiti

81 Here, we identified UBIQUITIN SPECIFIC PROTEASE 5 (UBP5) as a chromatin play

82 Here, we identify the ubiquitin-specific protease 5 (USP5) as a bona fide deub

83 The combination reduced ubiquitin-specific protease 5 (USP5) levels and increase

84 RNA screen, we identified the deubiquitylase ubiquitin-specific protease 6 (USP6) as a potent activat

85 We previously showed that ubiquitin-specific protease 6 (USP6) directly deubiquiti

86 We recently identified the TRE17/ubiquitin-specific protease 6 (USP6) oncogene as the fir

87 Here we report a role for the ubiquitin-specific protease 6 (USP6)/TRE17 oncogene, whi

88 Ubiquitin specific protease 7 (USP7) is a known deubiqui

89 Here, we identified ubiquitin specific protease 7 (USP7), a deubiquitinating

90 Ubiquitin specific protease 7 (USP7), the most widely st

91 ree reported macrocyclic peptides binding to Ubiquitin Specific Protease 7 (USP7).

92 ased HUWE1 transcription, and degradation of ubiquitin-specific protease 7 (USP7) and TRIP12.

93 Ubiquitin-specific protease 7 (USP7) deubiquitinates p53

94 Pathogenic variants in the ubiquitin-specific protease 7 (USP7) gene cause a neurod

95 Ubiquitin-specific protease 7 (USP7) has been implicated

96 The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation o

97 Ubiquitin-specific protease 7 (USP7) is a deubiquitinati

98 Human ubiquitin-specific protease 7 (USP7) is a deubiquitinati

99 Ubiquitin-specific protease 7 (USP7) is a deubiquitinati

100 Ubiquitin-specific protease 7 (USP7) is a deubiquitylase

101 Ubiquitin-specific protease 7 (USP7) is a prominent deub

102 For example, the inhibition of ubiquitin-specific protease 7 (USP7) results in the degr

103 at protein BUB3, which subsequently recruits ubiquitin-specific protease 7 (USP7) to remove ubiquitin

104 dentified the deubiquitinating enzyme (DUB), ubiquitin-specific protease 7 (USP7), as a novel regulat

105 Deletion of one interactor, ubiquitin-specific protease 7 (Usp7), results in impairm

106 by mutations in the deubiquitinating enzyme Ubiquitin-Specific Protease 7 (USP7).

107 ORF45: the viral protein ORF33 and cellular ubiquitin-specific protease 7 (USP7).

108 ded by herpes simplex virus 1 (HSV-1), binds ubiquitin-specific protease 7 (USP7).

109 IRFs 1, 3, and 4 are known to interact with ubiquitin-specific protease 7 (USP7); interactions of vI

110 ellular protein targeted by all the vIRFs is ubiquitin-specific protease 7 (USP7); while replication-

111 Here we have identified ubiquitin-specific protease 7 (USP7; also known as HAUSP

112 ound that inhibiting USP7 with the selective ubiquitin-specific protease 7 inhibitor (USP7i) FT671 in

113 TRIM27 and its deubiquitinating enzyme USP7 (ubiquitin-specific protease 7), resulting in significant

114 33 and the 130-kDa protein is cellular USP7 (ubiquitin-specific protease 7).

115 Inhibition of ubiquitin-specific protease 7, USP7, has been proposed a

116 vity-based chemical screening, we identified ubiquitin specific protease-7 (USP7) and USP10 that bind

117 We have identified the deubiquitinase Ubiquitin Specific Protease-7 (USP7) as a regulator of N

118 and are implicated in disease; for example, ubiquitin-specific protease-7 (USP7) regulates stability

119 Using an in vivo RNAi screen, we identified ubiquitin-specific protease 8 (USP8) as a deubiquitinase

120 Ubiquitin-specific protease 8 (USP8) has previously been

121 econd regulator of ubiquitin metabolism, the ubiquitin-specific protease 8 (USP8), is a downstream ta

122 TMEM79 interacts with ubiquitin-specific protease 8 (USP8), whose activating m

123 o reduced expression of the de-ubiquitinase, ubiquitin-specific protease 8 (USP8).

124 The deubiquitinating enzyme ubiquitin-specific protease 8 (USP8/UBPy) has been previ

125 Our results suggest that ubiquitin-specific protease 9X (USP9X) is by far the mos

126 l GSCs, are regulated posttranslationally by ubiquitin-specific protease 9X-mediated (USP9X-mediated)

127 Additionally, we determined that the ubiquitin-specific protease activity of the ORF UL48 pro

128 deubiquitinase HAUSP (herpesvirus-associated ubiquitin-specific protease; also named USP7) and blocke

129 lyQ disease protein, ataxin-3, has predicted ubiquitin-specific protease and ubiquitin-binding domain

130 s significant homology to well characterized ubiquitin-specific proteases and previously was shown to

131 tion structure of the BUZ domain of Ubp-M, a ubiquitin-specific protease, and its interaction with ub

132 tein homology domain at its N terminus and a ubiquitin-specific protease at its C terminus.

133 ic DUBs makes this new family of herpesvirus ubiquitin-specific proteases attractive targets for sele

134 Until now, whether deubiquitination by ubiquitin-specific proteases can regulate the clock prot

135 tyltransferase complex, including a putative ubiquitin-specific protease component.

136 interferon-stimulated gene encoding a 43-kDa ubiquitin-specific protease, designated ISG43, was ident

137 Here, we report that USP10, a cytoplasmic ubiquitin-specific protease, deubiquitinates p53, revers

138 USP53 contains a catalytically inactive ubiquitin-specific protease domain and is expressed in c

139 2s were similar, with a conserved N-terminal ubiquitin-specific protease domain separated from an int

140 ration of the inhibitory signal requires the ubiquitin-specific protease encoded by the fat facets ge

141 Recently, a ubiquitin-specific protease enzyme (named HAUSP) and a u

142 USP11 is a member of the ubiquitin-specific protease family and plays a crucial r

143 able to discern the differential activity of ubiquitin-specific protease family members (USP4, USP15,

144 chromosome 1q21 and encodes a member of the ubiquitin-specific protease family with highly conserved

145 Usp18 is an IFN-inducible member of the ubiquitin-specific protease family, which deconjugates u

146 ne of these genes, Usp18, is a member of the ubiquitin-specific protease family.

147 the 135 kDa protein as a novel member of the ubiquitin-specific protease family.

148 cle free monoubiquitin, and is one of the 12 ubiquitin specific proteases featuring a zinc finger ubi

149 an ecdysteroid-response gene, cabut, and an ubiquitin-specific protease gene, fat facets, with known

150 0 reported to abolish the interaction with a ubiquitin-specific protease has no effect on the functio

151 The ubiquitin-specific protease HAUSP is a critical componen

152 s, we have identified herpesvirus-associated ubiquitin-specific protease (HAUSP) as a novel p53-inter

153 the ability of Vmw110 to bind to a cellular ubiquitin-specific protease (HAUSP) is not required.

154 In this study, herpesvirus-associated ubiquitin-specific protease (HAUSP) was isolated as a bi

155 ng the deubiquitinase herpesvirus-associated ubiquitin-specific protease (HAUSP), which stabilizes RU

156 deubiquitination by Herpes virus associated ubiquitin-specific protease (Hausp, a.k.a Usp7), stabili

157 quitinylating enzyme, herpesvirus-associated ubiquitin-specific protease (HAUSP, also known as USP7),

158 Doa4 is a ubiquitin-specific protease in Saccharomyces cerevisiae

159 ith the recent discovery of the first potent ubiquitin-specific protease inhibitors, and the maturati

160 , our investigation also found that USP2a, a ubiquitin-specific protease, is significantly increased

161 protein 1, a ubiquitin-like 17-kDa protein, ubiquitin-specific protease ISG43, an RNA helicase DEAD

162 Vmw110 binds strongly and specifically to a ubiquitin-specific protease known as HAUSP, itself a com

163 n (VCP) and on ubiquitin chain remodeling by ubiquitin-specific proteases known as deubiquitinases (D

164 hydrolases (UCHs) comprise a family of small ubiquitin-specific proteases of uncertain function.

165 ed with and regulated by two isoforms of the ubiquitin-specific protease otubain 1.

166 Thus, USP21 is the first ubiquitin-specific protease shown to have dual specifici

167 r the influence of different combinations of ubiquitin-specific proteases, suggesting that they have

168 The B. mallei tssM gene encodes a putative ubiquitin-specific protease that is physically linked to

169 The ubiquitin-specific proteases (UBP) are a family of enzym

170 nalysis shows that it belongs to a family of ubiquitin-specific proteases (UBP), and its molecular ma

171 Here, we show that two ubiquitin-specific proteases, UBP12 and UBP13, deubiquit

172 Two ubiquitin-specific proteases, UBP12 and UBP13, were iden

173 These studies identified a ubiquitin-specific protease, Ubp3, as having an essentia

174 lts broaden the understanding of a new human ubiquitin-specific protease, UBP43, and suggest that thi

175 sing after the first di-glycine motif by the ubiquitin-specific proteases Ubp5 and Ubp15 generates a

176 uitinating module (DUBm), which contains the ubiquitin-specific protease Ubp8, bound to Sgf11, Sus1,

177 Ubiquitin-specific proteases (UBPs) are a family of uniq

178 re released and subsequently disassembled by ubiquitin-specific proteases (UBPs) to regenerate free u

179 erference screening to identify a human DUB, ubiquitin-specific protease (USP) 13, whose expression m

180 zyme ubiquitin C-terminal hydrolase 6 [Ubp6; ubiquitin-specific protease (USP) 14 in mammals] is the

181 Ubiquitin-specific protease (USP) 6 is a hominoid deubiq

182 TRE17 encodes a ubiquitin-specific protease (USP) and a TBC (TRE2-Bub2-C

183 rticularly key deubiquitinases (DUBs) of the ubiquitin-specific protease (USP) class.

184 The ubiquitin-specific protease (USP) family is the largest

185 ultispecificity, particularly binding to the ubiquitin-specific protease (USP) family of deubiquitina

186 The herpesvirus ubiquitin-specific protease (USP) family, whose founding

187 biquitination by USP33, as confirmed using a ubiquitin-specific protease (USP) pan-inhibitor and USP3

188 USP21 belongs to the ubiquitin-specific protease (USP) subfamily of deubiquit

189 TRE17 encodes a ubiquitin-specific protease (USP), and a TBC domain that

190 ed growth, we identified and characterized a ubiquitin-specific protease (USP), Puffyeye (Puf), as a

191 We also showed that ubiquitin-specific protease (USP)15 interacted with RORg

192 Ubiquitin-specific proteases (USP) are one class of DUBs

193 and AD is attributed to up-regulation of the ubiquitin-specific protease USP11, which deubiquitinates

194 noubiquitin from the ELK-1 ETS domain by the Ubiquitin Specific Protease USP17 was shown to augment E

195 Here, we identify the ubiquitin-specific protease USP21 as a positive regulato

196 rves as an obligate adaptor protein of three ubiquitin-specific proteases (USP22, USP27X or USP51).

197 In this study, we identified the ubiquitin-specific protease USP25 as a negative regulato

198 iated bivalent interactions with p53 and the ubiquitin-specific protease USP28.

199 l. merge these two themes by identifying the ubiquitin-specific protease Usp4 as a partner for the ca

200 We have now identified the cytoplasmic ubiquitin-specific protease USP47 as the major enzyme in

201 Here, we identify the ubiquitin-specific protease, USP50, as a chromatin-assoc

202 region on 16q22 is juxtaposed to the entire ubiquitin-specific protease USP6 (Tre2) coding sequence

203 as been previously reported to interact with ubiquitin-specific protease USP7 and regulate cell proli

204 we show that Hh stimulates the binding of a ubiquitin-specific protease Usp7 to Ci, which positively

205 ins had no effect on the distribution of the ubiquitin-specific protease USP7 within the cell, consis

206 tes resulting from our analysis included the ubiquitin-specific protease USP7, the transcriptional re

207 Here, we report the identification of a ubiquitin-specific protease, USP7, as a regulatory switc

208 Here, we report that two ubiquitin-specific proteases, USP7 and USP11, co-purify

209 entify a novel mTOR interacting protein, the ubiquitin-specific protease USP9X, which acts as a negat

210 d that Themis stability is controlled by the ubiquitin-specific protease USP9X, which removes ubiquit

211 Ubiquitin specific proteases (USPs) are de-ubiquitinases

212 Ubiquitin specific proteases (USPs), as the largest fami

213 is reversed by two deubiquitinating enzymes, ubiquitin-specific proteases (USPs) 20 and 33, thus, inh

214 Ubiquitin-specific proteases (USPs) are a family of mult

215 Ubiquitin-specific proteases (USPs) are crucial for cont

216 Ubiquitin-specific proteases (USPs) are the main members

217 Ubiquitin-specific proteases (USPs) constitute the large

218 Ubiquitin ligases (E3s) and ubiquitin-specific proteases (USPs) dynamically oppose e

219 Ubiquitin-specific proteases (USPs) represent the larges

220 Ubiquitin-specific proteases (USPs) reverse ubiquitinati

221 tant role in immune regulation; however, the ubiquitin-specific proteases (USPs) that carry out deubi

222 Ubiquitin-specific proteases (USPs) USP15 and USP4 belon

223 Ubiquitin-specific proteases (USPs), comprising the larg

224 proteases, such as caspases, cathepsins, and ubiquitin-specific proteases (USPs), regulate diverse im

225 ty for USP15 and close homologues over other ubiquitin-specific proteases (USPs).

226 Drosophila gene, scrawny (scny), encoding a ubiquitin-specific protease, which is required in germli