ライフサイエンスコーパス: ubiquitinated

1 milar to the wild-type receptor, but was not ubiquitinated.

2 unavailable, three nearby lysines may become ubiquitinated.

3 subunit intrinsic to the MCC (Cdc20(MCC)) is ubiquitinated, a process that results in APC/C reactivat

4 hibitors are known to prevent degradation of ubiquitinated AAV capsids, thereby leading to increased

5 tion by a stabilized XBAT35.2, the levels of ubiquitinated ACD11 increased considerably, and the abun

6 Finally, like constitutively ubiquitinated adaptors, a Ubp2 deficiency increased both

7 Both IL-4Ralpha and gammaC were ubiquitinated after 30 min of IL-4 treatment, suggesting

8 We found that p62 is increased and forms ubiquitinated aggregates due to decreased autophagic car

9 Tsa1 counteracted the accumulation of ubiquitinated aggregates during aging and the reduction

10 6 is involved in the autophagic clearance of ubiquitinated aggregates during which SQSTM1/p62 plays a

11 neurons form large autophagosomes containing ubiquitinated aggregates early in disease progression.

12 Ubiquitinated alpha-synuclein is targeted to proteasomal

13 Cohesin is known to be ubiquitinated, although the mechanism, regulation, and e

14 TrkA is ubiquitinated, among other E3 ubiquitin ligases, by Nedd

15 e used protein chemistry to first synthesize ubiquitinated analogues at three different positions usi

16 We show that KLHL41 is poly-ubiquitinated and acts, at least in part, by preventing

17 ncreased cytosolic sequestration of the poly-ubiquitinated and aggregated form of mutant TDP-43, whic

18 Although misfolded proteins are ubiquitinated and cleared by the proteasome, they can ac

19 other steroid receptors, which are typically ubiquitinated and degraded by proteasomes after ligand b

20 ting of the I-II loop of CaV2.2 was directly ubiquitinated and degraded by the proteasome system.

21 zed by binding to IP3Rs, that unbound Bok is ubiquitinated and degraded by the proteasome, and that b

22 Once exported from the nucleus, menin was ubiquitinated and degraded by the proteasome.

23 h-related proteins were identified that were ubiquitinated and degraded more rapidly after mTOR inhib

24 ng finger protein 41 (RNF41) as an E3 ligase ubiquitinated and degraded SGT1 in a phosphorylation-dep

25 These are subsequently ubiquitinated and degraded via the 26S proteasome, leadi

26 uished from their assembled counterparts and ubiquitinated and degraded within the nuclear compartmen

27 n (ERAD), by which misfolded ER proteins are ubiquitinated and degraded.

28 We propose that damaged mitochondria are ubiquitinated and dynamically encased in ER strands, pro

29 Detergent-resistant, ubiquitinated and hyperphosphorylated Tar DNA binding pr

30 Both the cytoplasmic accumulation of toxic ubiquitinated and hyperphosphorylated TDP-43 fragments a

31 the cilium, and the receptor is subsequently ubiquitinated and internalized.

32 RGS2 is rapidly ubiquitinated and proteasomally degraded, providing a po

33 version expressed in vivo, Lys-less IAA1 was ubiquitinated and rapidly degraded in vivo.

34 NALP7 is constitutively ubiquitinated and recruited to the endolysosome for degr

35 for degradation, and alpha-synuclein may be ubiquitinated and recycled in the normal brain.

36 of ligand-induced pathway activation, Smo is ubiquitinated and removed from cilia, and this process i

37 biquitinomes identified about 70 proteins as ubiquitinated and specifically modified with K63-linked

38 We found that USP-46 is ubiquitinated and that expression of WDR-48 reduces the

39 tion of structurally identical peptides from ubiquitinated and unmodified lysine residues following t

40 BFRF1 is ubiquitinated, and elimination of possible ubiquitinatio

41 4.7 or human HEK293 cells, were endocytosed, ubiquitinated, and released via exosomes.

42 Remarkably, DZIP3 interacted with, ubiquitinated, and stabilized Cyclin D1 predominantly in

43 -1 from cultured rat hippocampal neurons was ubiquitinated, and the levels of ubiquitinated Tomo-1 dr

44 ts that cannot be phosphorylated at Ser68 or ubiquitinated at Lys124 assemble efficiently at centrome

45 Accordingly, we reported that BACE1 is ubiquitinated at lysine 501 and that lack of ubiquitinat

46 Poleta has been shown to be ubiquitinated at one primary site.

47 onoubiquitinated poliota revealed that it is ubiquitinated at over 27 unique sites.

48 In Jurkat cells, ZAP-70 is ubiquitinated at several sites that are not sensitive to

49 ments revealed that GCGRs are constitutively ubiquitinated at the cell surface.

50 ss by nutrient starvation, agonist-activated ubiquitinated beta2ARs traffic to autophagosomes to colo

51 ic shock induces proteolysis of Bid and mono-ubiquitinated Bid at Asp-52 increasing the release of cy

52 e-wide screens have indicated that IQGAP1 is ubiquitinated, but the possible effects of this post-tra

53 at upon the induction of DNA damage, EXO1 is ubiquitinated by a member of the Skp1-Cullin1-F-box (SCF

54 suggesting that Lys(676) is physiologically ubiquitinated by CRL4(CRBN) The ACR facilitated in vitro

55 We identify a critical substrate ubiquitinated by CUL3-SPOPL as EPS15, an endocytic adapt

56 K6a in the cytosol is ubiquitinated by cullin-RING E3 ligases for subsequent p

57 PRMT5, beta-catenin, and UbxD8 are directly ubiquitinated by E6AP in vitro and in the cell.

58 Indeed, IFNAR1 was phosphorylated and ubiquitinated by IAV infection, which resulted in IFNAR1

59 HIF-1alpha is constitutively ubiquitinated by pVHL (von Hippel-Lindau protein) follow

60 However, HIF-1alpha is not recognized and ubiquitinated by pVHL in IPMK KO (knockout) cells.

61 ERAD substrates are ubiquitinated by the action of the Hrd1 RING-H2 E3 ligas

62 After phosphorylation, RECQL4 is ubiquitinated by the DDB1-CUL4A E3 ubiquitin ligase, whi

63 at Rab10 protein is recruited to the LCV and ubiquitinated by the effectors SidC/SdcA.

64 During the SAC, cyclin A2 is ubiquitinated by the repressed APC/C-MCC, mediated by th

65 e demonstrated that PKCzeta was specifically ubiquitinated by TRIM32 and, further, that PKCzeta stabi

66 p analysis confirmed that both proteins were ubiquitinated by TRIM32 in vitro; however, only NDRG2 ac

67 NG was dependent on K150 of STING, which was ubiquitinated by TRIM32.

68 o assemble with beta-globin were selectively ubiquitinated by UBE2O.

69 ns] mediate cargo degradation, concentrating ubiquitinated cargo and organizing the activities of ESC

70 p62 to LC3B, and it promotes degradation of ubiquitinated cargo by autophagy.

71 CALCOCO2), TAX1BP1, and p62 (SQSTM1) linking ubiquitinated cargo to autophagic membranes.

72 Inhibition of ubiquitinated cargo transport through the multivesicular

73 SQSTM1, which facilitates the degradation of ubiquitinated cargo.

74 which is crucial in determining the fate of ubiquitinated cargo.

75 ly select for the isolation membrane and the ubiquitinated cargo.

76 ls suggest that ESCRT-III complexes surround ubiquitinated cargoes to trap them at the site of ILV bu

77 as p62 (SQSTM1), to specifically bridge the ubiquitinated cargos into autophagosomes.

78 that TDP2 co-purifies with K63 and K27 poly-Ubiquitinated cellular proteins independently of, and se

79 hows stronger interaction with SUG1 and with ubiquitinated cellular proteins.

80 age in order to avoid excessive spreading of ubiquitinated chromatin.

81 yme, leading to a pronounced accumulation of ubiquitinated chromatin.

82 ction allows accumulation of both native and ubiquitinated CSB and results in an increase of UBXD7, p

83 CP/p97 segregase in the timely processing of ubiquitinated CSB from damaged chromatin.

84 ha proteasome and PR1a, and the detection of ubiquitinated CTB polypeptides revealed that N-glycosyla

85 fication cycle caused by the accumulation of ubiquitinated cyclin E.

86 es recruitment and retention of OPTN/TBK1 on ubiquitinated, damaged mitochondria.

87 ation of DELLA was enhanced by COP1 and COP1 ubiquitinated DELLA proteins in vitro.

88 EX5 and PMP70 as substrates of PEX2 that are ubiquitinated during amino acid starvation.

89 However, PCNA is also ubiquitinated during normal S-phase progression.

90 Ubiquitinated E is present on infectious virions of ZIKV

91 it), which inhibits the Hrs association with ubiquitinated EGFR.

92 The level of ubiquitinated ELK-1 rises in mitogen-deprived cells and

93 endothelial cells, epsins interact with the ubiquitinated endoplasmic reticulum protein inositol 1,4

94 teracting specifically with the UIM and with ubiquitinated epsin.

95 Cdc48 binding to retrotranslocated, ubiquitinated ERAD-M substrates is required for their so

96 me complex Upb3-Bre5 increased the levels of ubiquitinated eS7A during UPR in an Ire1-independent man

97 mbrane into the cytosol, where they are poly-ubiquitinated, extracted from the membrane, and degraded

98 in degradation (ERAD), membrane proteins are ubiquitinated, extracted from the membrane, and degraded

99 Similarly, non-ubiquitinated FANCD2 can still support proliferation cel

100 ZAPL-associated PB2 and PA proteins are then ubiquitinated, followed by proteasomal degradation.

101 lded alpha-synuclein accumulates, often in a ubiquitinated form, in neuronal inclusions termed Lewy b

102 rons increased the fraction of Lys-63-linked ubiquitinated GABAB receptors and enhanced the expressio

103 ively regulating CycB transcription, the Fzr-ubiquitinated H2B (H2Bub)-Myc signaling cascade also pos

104 n the rapid and efficient synthesis of Lys34-ubiquitinated H2B and for the first time neddlyated pept

105 ue, together with semisynthetically prepared ubiquitinated H2B, enabled us to provide direct evidence

106 these E3 ligases, PDIA3 was shown to cleave ubiquitinated HC molecules to accelerate HC dislocation.

107 of USP7 leads to a reduction in the level of ubiquitinated histone H2A (H2Aub), the catalytic product

108 iculum (ER)-associated degradation (ERAD) of ubiquitinated HMG CoA reductase (HMGCR), the rate-limiti

109 mutant to trap and identify more than 180 PR-ubiquitinated host proteins in Legionella-infected cells

110 on, we have identified a list of specific PR-ubiquitinated host targets and show that DupA and DupB p

111 y a role in modulating the association of PR-ubiquitinated host targets with Legionella-containing va

112 lla pneumophila resides in a vacuole that is ubiquitinated; however, this pathogen avoids xenophagic

113 By comparison with the structure of the non-ubiquitinated ID complex bound to ICL DNA-which we also

114 Ubiquitinated Id-1/Id-2 can then bind to p62 and be tran

115 Furthermore, ubiquitinated ID1 protein was not detected in lactacysti

116 , the PDGF beta receptor (PDGFRbeta) becomes ubiquitinated in a manner requiring both the c-Cbl and C

117 We further show that SnRK1 is ubiquitinated in a SIZ1-dependent manner, causing its de

118 Indeed, EPS15 is ubiquitinated in a SPOPL-dependent manner, and accumulat

119 inically relevant AR-variants it can only be ubiquitinated in cells when AR retains LBD suggesting a

120 pro-inflammatory mediator, was specifically ubiquitinated in lipopolysaccharide-induced pro-inflamma

121 CAR9 proteins were accumulated and more were ubiquitinated in lot1.

122 FDH is ubiquitinated in planta and degraded by the 26S proteaso

123 We show here that hD4R is ubiquitinated in primary neurons.

124 During the cell cycle, p50 is mono-ubiquitinated in S phase and loss of this post-translati

125 thermore, we show that one of these sites is ubiquitinated in the absence of acetylation and that ace

126 quence AR variants lacking the LBD cannot be ubiquitinated in the cellular environment and their prot

127 o MIB1 upon AdV infection and differentially ubiquitinated in the presence or absence of MIB1, we obs

128 ients shows degeneration of the striatum and ubiquitinated inclusions immunoreactive for polyglutamin

129 N proteins from the CGG repeat accumulate in ubiquitinated inclusions in FXTAS patient brains and eli

130 generates novel proteins that accumulate in ubiquitinated inclusions in FXTAS patients.

131 d-stage disease revealed the accumulation of ubiquitinated inclusions in the brain and spinal cord, a

132 , and consequent clearance of stress-induced ubiquitinated-insoluble proteins.

133 ubiquitin and ubiquitinated-PCNA and is also ubiquitinated itself.

134 d quantitative mass spectrometry to identify ubiquitinated kinases and the sites of ubiquitination in

135 p1 transmembrane domain, and 3) close to the ubiquitinated lysines.

136 Targeted ubiquitinated mitochondria are cradled by endoplasmic re

137 SQSTM1 can bind to LC3 on autophagosomes and ubiquitinated molecules on cargos, thus facilitating the

138 gs Dom34-Hbs1 affect the total population of ubiquitinated nascent chains associated with yeast ribos

139 During RQC, ANKZF1 (yeast Vms1p) releases ubiquitinated nascent proteins from 60S ribosomal subuni

140 egates in FXTAS patients and colocalize with ubiquitinated neuronal inclusions.

141 ryo-EM structures of Dot1L in complex with a ubiquitinated nucleosome provide the long-sought-after m

142 Ubp8/Sgf11/Sus1/Sgf73 DUB module bound to a ubiquitinated nucleosome reveals that the DUB module pri

143 rt here cryo-EM structures of Dot1L bound to ubiquitinated nucleosome that show how H2B-Ub stimulates

144 structure of Set2 bound to the mimic of H2B ubiquitinated nucleosome.

145 H3K4 and be stimulated by H2B-Ub, bound to a ubiquitinated nucleosome.

146 lowing the DUB module to bind one face of an ubiquitinated nucleosome.

147 Under inflammatory conditions, ubiquitinated Nur77 resides at mitochondria, rendering t

148 The current study showed that the ubiquitinated OAT1 accumulated in the presence of the pr

149 , this study identified the pathway in which ubiquitinated OAT1 degrades and unveiled a novel role of

150 s leupeptin and pepstatin A, suggesting that ubiquitinated OAT1 degrades through proteasomes.

151 rt activity by preventing the degradation of ubiquitinated OAT1 in proteasomes.

152 omib and carfilzomib extremely increased the ubiquitinated OAT1, which correlated well with an enhanc

153 cipitation assays, we show here that VP35 is ubiquitinated on lysine 309 (K309), a residue located on

154 n which individual ubiquitin moieties may be ubiquitinated on one or multiple residues, and/or modifi

155 ce that express a mutant MHC II unable to be ubiquitinated or mice that lack membrane-associated RING

156 Ubiquitinated PalF triggers downstream signalling events

157 Because HDAC6 can transport ubiquitinated pathological aggregates to the MTOC for ag

158 A widely-accepted model purports that ubiquitinated PCNA recruits TLS polymerases such as pol

159 ATAD5-RLC could unload ubiquitinated PCNA.

160 nuclear antigen (PCNA), Rev1, ubiquitin and ubiquitinated-PCNA and is also ubiquitinated itself.

161 recipitates with fewer high-molecular-weight ubiquitinated peptide species, suggesting partial loss-o

162 PEX26 tail-anchored membrane protein removes ubiquitinated PEX5 from the peroxisomal membrane.

163 itination machinery mutants, suggesting that ubiquitinated PEX5 is degraded by the proteasome when th

164 Parkin interacted with PHGDH and ubiquitinated PHGDH at lysine 330, leading to PHGDH degr

165 e gene and tumor suppressor Parkin bound and ubiquitinated PHGDH.

166 protein and its cofactor, UFD1, then target ubiquitinated PINK1 for proteasomal degradation.

167 Ubiquitinated plasma membrane proteins (cargo) are deliv

168 up45-Sup35 strongly influences the amount of ubiquitinated polypeptides associated with 60S ribosomal

169 tin ligase (E3) Ubr1, while sam35-2HA(ts) is ubiquitinated primarily by San1.

170 lysis degradation pathway genes resulting in ubiquitinated protein accumulation in muscle.

171 ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skel

172 n and proteolytic sequestration of insoluble ubiquitinated protein aggregates associated with p62 and

173 eriments revealed accumulations of insoluble ubiquitinated protein aggregates associated with the ada

174 teasome, reduces both the size and number of ubiquitinated protein aggregates in aged flies, and incr

175 Ubiquitinated protein aggregates, of which TDP-43 is a m

176 R stress sensitivity and the accumulation of ubiquitinated protein aggregates, whose efficient degrad

177 autophagosomal protein LC3 and clearance of ubiquitinated protein aggregates.

178 ssion level is closely linked to the rate of ubiquitinated protein aggregation, which are themselves

179 However, the regulation of ubiquitinated protein degradation in healthy, nonatrophy

180 Our results suggest that ubiquitinated protein formation may be abnormal in both

181 The well described accumulation of ubiquitinated protein inclusions in neurodegenerative di

182 in 43 (TDP-43) is the principal component of ubiquitinated protein inclusions present in nervous tiss

183 Ubiquitinated protein levels were elevated in postmortem

184 lation of both early endosome processing and ubiquitinated protein sorting.

185 y WT proteasomes is activated if they bind a ubiquitinated protein, which is loosely folded.

186 mpairment and an accumulation of nondegraded ubiquitinated protein.

187 Usp14 are much more active in degrading non-ubiquitinated proteins (e.g. Sic1) than WT particles.

188 Finally, ubiquitinated proteins accumulate in cilia of mammalian

189 over, the overexpression of PARK2 diminished ubiquitinated proteins accumulation, improves its target

190 CHIP-S20E knock-in mice better clear ubiquitinated proteins and are cardio-protected.

191 ration was accompanied by an accumulation of ubiquitinated proteins and decreased xeroderma pigmentos

192 receptor hRpn13, triggering accumulation of ubiquitinated proteins and endoplasmic reticulum stress-

193 correlate with an increased accumulation of ubiquitinated proteins and expression of CIN85/RukL in p

194 and the 26S proteasomes' capacity to degrade ubiquitinated proteins and peptides.

195 f desmin filaments caused an accumulation of ubiquitinated proteins and rapid destruction of myofibri

196 ccumulated abnormally, and co-localized with ubiquitinated proteins and the prelysosomal markers HRS

197 c stress conditions allows cells to react to ubiquitinated proteins and to assemble nuclear, liquid c

198 y of brain 26S proteasomes, higher levels of ubiquitinated proteins and undegraded Ub-G76V-GFP.

199 proteasome activities and cellular levels of ubiquitinated proteins by activating protein kinase G (P

200 the FIP200 CTR slows the phase separation of ubiquitinated proteins by p62 in a reconstituted system.

201 ing in accumulation of oxidative lesions and ubiquitinated proteins during heat stress in CWD clams.

202 A protocol to enrich K6-ubiquitinated proteins from cells identifies HUWE1 as a

203 ubstrates, likely by facilitating release of ubiquitinated proteins from the OMM.

204 When degradation of ubiquitinated proteins in cells was inhibited, levels of

205 evalence of receptors such as agglutinin and ubiquitinated proteins in ciliary ectosomes suggests tha

206 ce and promoted the degradation of insoluble ubiquitinated proteins in CryAB(R120G) cardiomyocytes bu

207 esistant' schizophrenia had higher levels of ubiquitinated proteins in erythrocytes compared to those

208 Furthermore, a proteomics screen comparing ubiquitinated proteins in hearts from Parkin(-/-) and Pa

209 enlargement, and cytoplasmic accumulation of ubiquitinated proteins in HeLa cells and wild-type mouse

210 with this view, NAC abolished an increase in ubiquitinated proteins in MG132-treated astrocytes.

211 formation of p62/SQTM1 aggregates containing ubiquitinated proteins in structures known as aggresome-

212 om HCT116 cells to cause increased levels of ubiquitinated proteins in whole-cell extract and at prot

213 respect to endosomal movement and sorting of ubiquitinated proteins into lysosomes, its function in m

214 mplex components and have elevated levels of ubiquitinated proteins prior to manifestation of cardiom

215 Tom1 transports endosomal ubiquitinated proteins that are targeted for degradation

216 ss, which is characterized by the buildup of ubiquitinated proteins that cannot be degraded properly.

217 Moreover, adding ubiquitinated proteins to cell extracts stimulated prote

218 a new strategy for the chemical synthesis of ubiquitinated proteins to generate a set of well-defined

219 quitin-like domain and is thought to deliver ubiquitinated proteins to proteasomes for degradation.

220 e the delivery of hydrophobic and aggregated ubiquitinated proteins to the proteasome for degradation

221 The digestion of ubiquitinated proteins with trypsin yields a glycine-gly

222 reduced PSMD12 levels and an accumulation of ubiquitinated proteins without any impairment of proteas

223 We examined free mono-ubiquitin, ubiquitinated proteins, catalytic ubiquitination, and pr

224 abnormal ubiquitination and accumulation of ubiquitinated proteins, including TDP-43 and a SCF(Cycli

225 rtezomib and SP1017 augments accumulation of ubiquitinated proteins, increases markers of proteotoxic

226 monstrate reduced levels of proteasome-bound ubiquitinated proteins, indicating that the loss of hRpn

227 penetrates cells, it causes accumulation of ubiquitinated proteins, inhibits human 20S proteasomes,

228 tin to substrates, recognizing or processing ubiquitinated proteins, or constituting or regulating th

229 rected to the LDs via SQSTM1, which bound to ubiquitinated proteins, possibly including perilipin 1,

230 V), mutant profilin1 aggregation, abnormally ubiquitinated proteins, reduced choline acetyltransferas

231 with tau and were less active in hydrolyzing ubiquitinated proteins, small peptides and ATP.

232 control cells and treated with PKA degraded ubiquitinated proteins, small peptides, and ATP more rap

233 There was no overall increase in ubiquitinated proteins, suggesting the ubiquitin-proteas

234 ned Hspa1B (heat shock protein 1B hsp70) and ubiquitinated proteins, trapped other cytoskeletal prote

235 tant is altered in interaction with SUG1 and ubiquitinated proteins, triggering constitutive caspase-

236 ding of RHBDL4 to p97/VCP and Lys(63)-linked ubiquitinated proteins.

237 ysis and enhance proteasomal specificity for ubiquitinated proteins.

238 basal ATP consumption and degradation of non-ubiquitinated proteins.

239 led to exert protection or blunt the rise in ubiquitinated proteins.

240 ransport (ESCRT) [10-12], small GTPases, and ubiquitinated proteins.

241 of high molecular weight TDP-43 species and ubiquitinated proteins.

242 , accompanied by an increase of oxidized and ubiquitinated proteins.

243 target oligomers assembled from N-terminally ubiquitinated proteins.

244 nhibitor AUY922 promoted the accumulation of ubiquitinated proteins.

245 ivity upon interacting with ubiquitin and/or ubiquitinated proteins.

246 tative proteomic approaches to determine the ubiquitinated proteome after arsenic exposure, which hel

247 n ubiquitin-binding protein that targets the ubiquitinated receptor to lysosomal degradation and prom

248 rt (ESCRT) machinery responsible for sorting ubiquitinated receptors into intraluminal vesicles (ILVs

249 trafficking and sorting of internalized and ubiquitinated receptors.

250 eficient cells accumulate phosphorylated and ubiquitinated replication protein A (ubq-pRPA), the latt

251 We identified K125 as the ubiquitinated residue on CARD9 and demonstrated that thi

252 We found that K63 ubiquitinated ribosomes are also present in a polysome a

253 We further showed that K63 ubiquitinated ribosomes are captured uniquely at the rot

254 rst three-dimensional (3D) structures of K63 ubiquitinated ribosomes from oxidatively stressed yeast

255 on, leading to prolonged accumulation of K63-ubiquitinated RIP within the TNFR1 signaling complex.

256 inhibition led to accumulation of K48-linked ubiquitinated RIPK3, which was partially reduced when Ly

257 Ubiquitinated RNAPII showed similar enrichment.

258 Our data support a model whereby ubiquitinated Rsp5 adaptors are more active when "locked

259 tosome (SQSTM1, p62) mediated association of ubiquitinated SLiPs to the autophagy gene product LC3.

260 AREL1 ubiquitinated SMAC, primarily on Lys(62) and Lys(191) We

261 We found increased levels of poly-ubiquitinated SMAD7 in sCYLD CD4(+) T cells.

262 fically interact with Smurf1 and deliver the ubiquitinated Smurf1 for degradation.

263 es results in significant accumulation of PR-ubiquitinated species in host cells infected with Legion

264 VCP-mediated dislocation and presentation of ubiquitinated sperm mitochondrial proteins to the 26S pr

265 Thus, without a ubiquitinated substrate present, Usp14 suppresses multip

266 f the Golgi t-SNARE syntaxin 5 (Syn5) as the ubiquitinated substrate.

267 t protease that forms a ternary complex with ubiquitinated substrates and p97/VCP (valosin-containing

268 ) is the movement, or retrotranslocation, of ubiquitinated substrates from the ER lumen or membrane t

269 perated to bring about retrotranslocation of ubiquitinated substrates from the OEM (fulfilling conduc

270 by the accumulation of LC3, SQSTM1/p62, and ubiquitinated substrates in an expanded population of au

271 th accumulation of free ubiquitin chains and ubiquitinated substrates in the leon mutant.

272 p97-R155C can be recruited to ubiquitinated substrates on chromatin, but is unable to

273 on and off proteasomes, and the presence of ubiquitinated substrates promotes their association.

274 The global map of PR-ubiquitinated substrates provides critical insights into

275 By using this protocol, ubiquitinated substrates that are specific for a given l

276 d to serve as shuttling factors that deliver ubiquitinated substrates to the proteasome.

277 nt of single-molecule sensing of differently ubiquitinated substrates with different biological signi

278 , which largely relies on the degradation of ubiquitinated substrates, is instrumental for maintenanc

279 ain(s) that interact with the proteasome and ubiquitinated substrates, respectively.

280 system locally regulates the accumulation of ubiquitinated substrates, triggering presynaptic differe

281 Given the high affinity of DupA to PR-ubiquitinated substrates, we exploited a catalytically i

282 ases, DupA displays increased affinity to PR-ubiquitinated substrates, which allows DupA to cleave PR

283 ocesses through ATP-dependent degradation of ubiquitinated substrates.

284 inding domain, which allows the isolation of ubiquitinated substrates.

285 Conversely, ectopic expression of Mex3b ubiquitinated SUZ12, displaced DDX5 from HOTAIR, and ind

286 Subsequently, ubiquitinated Syn5 recruits p97/p47 to the mitotic Golgi

287 loss of Bassoon leads to elevated levels of ubiquitinated synaptic proteins per se.

288 We identify RIPK1 and caspase-8 as linearly ubiquitinated targets of LUBAC following TRAIL stimulati

289 sitive aggregates, suggestive of accumulated ubiquitinated targets.

290 Furthermore, we found that accumulation of ubiquitinated TLR4 and binding of E3 ubiquitin ligase Tr

291 neurons was ubiquitinated, and the levels of ubiquitinated Tomo-1 dramatically increased upon pharmac

292 ired for ICL repair, is recruited to ICLs by ubiquitinated (Ub) Fancd2.

293 We previously found that JAK2 is promptly ubiquitinated upon cytokine stimulation.

294 enous JAK2 and phospho-JAK2 were rapidly K63-ubiquitinated upon TPO stimulation, and this action was

295 These tests revealed that ubiquitinated vacuole membrane proteins recruit ESCRTs t

296 , namely Tau and apoE, interact with and are ubiquitinated via the ACR in vitro This, and the evidenc

297 eins, RALY and hnRNP-C, which we confirm are ubiquitinated without degradation.

298 ults in a drastic reduction in the levels of ubiquitinated XBAT35.2 and an increase in the abundance

299 interaction is crucial for trafficking of a ubiquitinated yeast SNARE (Snc1).

300 atively stable but that at least a subset of ubiquitinated Zta molecules are targeted for degradation