ライフサイエンスコーパス: ulceration

1 al outcomes (i.e., gastric cancer and peptic ulceration).

2 keratitis is characterized by severe corneal ulceration.

3 cosae of RAS patients not affected by active ulceration.

4 glycolysis (Warburg effect), associated with ulceration.

5 reviously unrecognised cause of chronic skin ulceration.

6 ially successful treatment for diabetic foot ulceration.

7 lerosis, postthrombotic syndrome, and venous ulceration.

8 significant linkage between PHIP levels and ulceration.

9 with a livedolike appearance and superficial ulceration.

10 n (PHIP) copy number and its relationship to ulceration.

11 ation-induced oral mucositis, a painful oral ulceration.

12 tients may develop bleeding caused by stress ulceration.

13 creased disease severity, and prevented skin ulceration.

14 digital images recording possible subsequent ulceration.

15 y begin in a wound, most often a neuropathic ulceration.

16 from mild erythema to moist desquamation and ulceration.

17 nostic information than the mere presence of ulceration.

18 tation and lipodermatosclerosis of skin, and ulceration.

19 he pathogenesis of gastric cancer and peptic ulceration.

20 major cause of gastric carcinoma and peptic ulceration.

21 P = 0.0053), but not among patients without ulceration.

22 n areas with teeth and took the form of oral ulceration.

23 nd epithelial cell exfoliation, erosion, and ulceration.

24 patients (n = 70) who denied any history of ulceration.

25 Most common toxicity was mild aphthous ulceration.

26 33% of patients reporting multiple sites of ulceration.

27 ammatory settings dominated by cell loss and ulceration.

28 eyelid meibomian glands, leading to corneal ulceration.

29 after treatment, without pain, crusting, or ulceration.

30 valves (VVs) prevent venous hypertension and ulceration.

31 constituents ameliorate ASA-induced gastric ulceration.

32 d did not have cutaneous or gastrointestinal ulceration.

33 a, low mitotic activity, focal necrosis, and ulceration.

34 rized by chronic inflammation and urothelial ulceration.

35 perficial vessel wall erosion induced by the ulceration.

36 almitis, and infectious keratitis or corneal ulceration.

37 proximal to mid jejunum and jejunal mucosal ulcerations.

38 condition involving painful and deep mucosal ulcerations.

39 o pseudomembrane-covered, irregularly-shaped ulcerations.

40 0.14) was protective, for the development of ulcerations.

41 sis in the colonic epithelium and subsequent ulcerations.

42 condition characterized by chronic cutaneous ulcerations.

43 -14] applications) which produced epithelial ulcerations.

44 tion, palmar violaceous papules, and digital ulcerations.

45 tion, palmar violaceous papules, and digital ulcerations.

46 ish-red infiltrations to mutilating necrotic ulcerations.

47 x wall thickness) + (1.97 x edema) + (0.83 x ulceration) + (0.55 x SUVmax ratio) + 1.14.

48 The most common adverse events were mouth ulceration (25 [32%] in the everolimus group vs two [5%]

49 pulmonary embolus prevention (42%) or venous ulceration (25%).

50 Stomatitis (48 [43%] patients) and mouth ulceration (33 [30%] patients) were the most frequent tr

51 pithelial defects, 25%, 3 days; conjunctival ulceration, 39%, 3.5 days; symblepharon, 28%, 4 weeks; c

52 %), photosensitivity (60.9%), and oral/nasal ulcerations (43.5%), but a lower prevalence of hematolog

53 of 1769 patients were analyzed (1311 without ulceration, 458 with ulceration) with a median follow-up

54 [44%]), xerosis (8 [20%]), scrotal erythema/ulceration (6 [15%]), and nail splinter hemorrhages (5 [

55 prolong the existence of already established ulcerations, affecting tissue healing.

56 Foot ulceration affects a significant proportion of patients

57 thickness or < 0.8 mm Breslow thickness with ulceration) after a thorough discussion with the patient

58 ed with the year of publication, female sex, ulceration, age, and the quality score of the studies.

59 PAD is a major risk factor for diabetic foot ulceration and amputation.

60 the divergent trends in incidence of peptic ulceration and apparent trends in diagnosis of upper gas

61 with marked lethal toxin-induced intestinal ulceration and bleeding in neutrophil elastase(+/+) anim

62 e use of aspirin is its side effect to cause ulceration and bleeding in the gastrointestinal tract.

63 een neutrophil presence at sites of melanoma ulceration and cell proliferation at these sites, which

64 omplications were as follows: for lid margin ulceration and corneal epithelial defects, 25%, 3 days;

65 non and its ischaemic complications (digital ulceration and critical ischaemia) and discusses possibl

66 ation in wild type mice, caused marked colon ulceration and delayed ulcer healing in GM-CSF(-/-) mice

67 oss changes to crypt architecture, including ulceration and denuding of the epithelial layer.

68 s the strongest known risk factor for peptic ulceration and distal gastric cancer, and adherence of H

69 Esophageal ulceration and fistula are complications of pulmonary ve

70 the human stomach and contributes to peptic ulceration and gastric adenocarcinoma.

71 on of intra-epithelial pustules resulting in ulceration and hypodermal necrosis.

72 negligible; one patient experienced grade-3 ulceration and infection.

73 Jup mutant mice also suffered skin ulceration and inflammation.

74 opment), hemochromatosis (involved in venous ulceration and iron absorption), and various types of co

75 djusting for significant prognostic factors (ulceration and lymph node status) and treatment.

76 first time, lichenoid esophagitis may cause ulceration and mucosal sloughing severe enough to result

77 ced type 2 immune response and an absence of ulceration and necrosis during cutaneous leishmaniasis.

78 stellate purpuric lesions that often undergo ulceration and necrosis, increasing the risk of infectio

79 hronic inflammatory complications, including ulceration and neovascularization.

80 edictive of positive non-SLNs; primary tumor ulceration and number of positive SLNs had no apparent i

81 atment include severe emesis and nausea, and ulceration and pain at the injection site.

82 involving nodular gingival enlargement with ulceration and periodontal tissue destruction.

83 Angiotropism in melanoma correlates with ulceration and poor prognosis.

84 Dose-limiting toxicities were rectal ulceration and proteinuria at the 7.0 mg/kg dose.

85 -dependent thermal injury model in mice with ulceration and scar formation that depended on nonredund

86 a increases epidermal injury with subsequent ulceration and scarring, both clinically and morphologic

87 tients with SS, severity of dryness, corneal ulceration and scarring, cataract, and glaucoma are fact

88 n with complement activation that results in ulceration and scarring.

89 reatment significantly reduced the degree of ulceration and the time of healing.

90 nodal involvement, number of positive nodes, ulceration and tumor thickness, sex, and center.

91 and treat promptly to minimize the risk for ulceration and visual loss.

92 is involved in P. aeruginosa-induced corneal ulceration and whether it therefore can be targeted for

93 n to a persistent, metastatic disease, where ulcerations and granulomatous nodules can affect multipl

94 ermatosis characterized by painful cutaneous ulcerations and often associated with systemic inflammat

95 w thickness >/= 0.75 mm, Clark level >/= IV, ulceration, and absence of regression differed significa

96 nodes, primary tumor thickness, patient age, ulceration, and anatomic site of the primary independent

97 corneal disease (vascularization, scarring, ulceration, and conjunctivalization), history of conjunc

98 dy found the prevalence rate of PED, corneal ulceration, and corneal perforation in chronic oGVHD to

99 g complications, including scleral thinning, ulceration, and delayed conjunctival epithelialization;

100 (FCL: 998) coincided with chronic intestinal ulceration, and finally 50 samples from 19 patients (FCL

101 opment and progression of gastritis, gastric ulceration, and gastric cancer, this dual regulatory rol

102 is, pulmonary arterial hypertension, digital ulceration, and gastro-oesophageal reflux, are now treat

103 The degree of stenosis, plaque ulceration, and intraplaque hemorrhage were not associat

104 ess more than 0.75 mm, MR >/= 1, presence of ulceration, and LVI (all P = .001) were significantly as

105 or larger, increasing Clark level, mitoses, ulceration, and lymphovascular invasion were independent

106 r MM only, melanoma type, Breslow thickness, ulceration, and mortality.

107 tients were stratified by Breslow thickness, ulceration, and nodal status.

108 he number of tumor-containing nodes, primary ulceration, and patient age independently predicted surv

109 , hematuria, dysuria, painful right inguinal ulceration, and right scrotal abscess drainage.

110 uction, amblyopia, or feeding difficulties), ulceration, and severe anatomic distortion, especially o

111 percentage of goal calories received, nasal ulceration, and sinusitis.

112 ugh workup ruled out other causes of genital ulceration, and the ulcers completely resolved after tre

113 ly experience pain and are at risk of falls, ulcerations, and amputations.

114 ccumulation, intraplaque hemorrhages, plaque ulcerations, and phosphoactivated endoplasmic reticulum

115 ng, hypercytokinemia, T cell cytopenia, skin ulcerations, and premature death.

116 Ulcerations appeared to be pathogenetically important, b

117 Skin infections with ulceration are a major health problem in countries of th

118 Plaque rupture and ulceration are common in women with myocardial infarctio

119 ts and decisions made by nurses managing leg ulceration are complex and uncertain and some of the var

120 nsertion and four cases of superficial nasal ulceration associated with the bridle.

121 We recommend that extent of ulceration be recorded in pathology reports for all ulce

122 IND administration induced significant ulceration, bleeding, and oedema in the stomach or small

123 Immunization with rTP0136 delayed ulceration but did not prevent infection or the formatio

124 was associated with the presence of gastric ulceration but not gastric cancer.

125 proliferation and cell migration at sites of ulceration compared to WT mice; these reductions correla

126 The slit-lamp characteristics of the corneal ulceration, corrected distance visual acuity, duration u

127 taract, trachoma control, infectious corneal ulceration, cytomegalovirus retinitis, and retinopathy o

128 Diabetic foot ulcerations (DFUs) represent a major medical, social, an

129 ere intestinal defects that included mucosal ulcerations, epithelial cell sloughing, and inflammation

130 esions among groups were compared by size of ulceration, exact area (mm(2) ) or relative area (%), an

131 was a statistically significant increase in ulceration for CM with a depth of approximately 1.4 per

132 er pylori infection, and prophylaxis against ulceration from nonsteroidal anti-inflammatory drugs.

133 ired NF-kappaB activation, develop cutaneous ulceration from TNF exposure, and exhibit severe dextran

134 audication (N=8128), rest pain (N=3056), and ulceration/gangrene (N=11,770) and Current Procedural Te

135 rest pain (P=0.061), and no improvement for ulceration/gangrene (P=0.65).

136 t environment, increasing the risk of peptic ulceration, gastric adenocarcinoma, and possibly other d

137 ich is associated with development of peptic ulceration, gastric atrophy, and gastric adenocarcinoma.

138 ked to discontinue ring use early because of ulcerations (grade 1) near the ring; in the remaining tw

139 Patients with open-foot and healed-foot ulceration had significantly longer RA disease duration,

140 To our knowledge, neurotrophic corneal ulceration has not previously been reported after retina

141 CI, 1.00-1.01; P = .02) and the presence of ulceration (HR, 1.21; 95% CI, 1.01-1.45; P = .04) were a

142 cterized by clinical inflammation, bleeding, ulceration, hyperplasia, and necrosis was observed aroun

143 CD [SES-CD] of 7 or more, 1 or more mucosal ulcerations [identified by endoscopy], and failure of co

144 loss of ATP2C1 function, which leads to skin ulceration, improper keratinocyte adhesion, and cancer f

145 diameter was 85 mm (55-250 mm), with mucosal ulceration in 4 patients, preoperative capsular rupture

146 tiology of autosomal-dominant, mucocutaneous ulceration in a family whose proband was dependent on an

147 slands-Haemophilus ducreyi-as causes of skin ulceration in a yaws-endemic region.

148 The detection of ulceration in melanomas with thicker than 1 mm increased

149 1 significantly reduced the extent of tongue ulceration in mice receiving a single fraction, high dos

150 e treatment as well as prevention of corneal ulceration in the developing world.

151 a 3 times higher risk of developing corneal ulceration in the first year.

152 ll bowel, and the other had chronic ischemic ulceration in the ileum.

153 itis, which creates painful inflammation and ulceration in the oral cavity.

154 ouse leading to neutrophil infiltration with ulceration in the upper dermis of homozygous offspring.

155 lted in little epithelial damage and mucosal ulceration in wild type mice, caused marked colon ulcera

156 ated superficial thermal lesions and thermal ulcerations in 1 of 50 (2%) and 5 of 50 (10%) patients,

157 se activity, and illness features, including ulcerations in children and pericarditis in adults.

158 -FDG uptake was found in 87% of deep mucosal ulcerations in IBD patients, whereas mild endoscopic les

159 of NGF was introduced to treat neurotrophic ulcerations in patients.

160 neuropathy (DPN) often leads to neurotrophic ulcerations in the cornea and skin; however, the underly

161 capsule showed red spots in the duodenum and ulcerations in the jejunum and proximal ileum covered by

162 f decompensated liver cirrhosis, varices and ulcerations in the upper gastrointestinal tract.

163 trointestinal anastomotic stenosis, marginal ulceration, incisional hernia.

164 The risk of incident venous leg ulceration increased for patients living in areas of hig

165 esions of the head and neck, the presence of ulceration, increasing Breslow thickness, older age, and

166 a histolytica kills human cells resulting in ulceration, inflammation and invasion of the colonic epi

167 0 treatment on wound heal-ing, the degree of ulceration, inflammation, angiogenesis, and collagen syn

168 rointestinal manifestations included gastric ulceration, intestinal bacterial overgrowth with villous

169 ts as endoscopically visible surface mucosal ulcerations, irregularities, or polyploidal masses.

170 Ulceration is a common negative prognostic marker of sol

171 While ulceration is a common, predominantly benign complicatio

172 Diabetic foot ulceration is a major complication of diabetes.

173 These data support the conclusion that ulceration is a predictive marker for response to adjuva

174 Diabetic foot ulceration is a severe complication of diabetes that lac

175 Ulceration is an adverse prognostic factor for clinicall

176 Tumor ulceration is an important prognostic factor for cutaneo

177 Ulceration is an important prognostic factor in melanoma

178 The signaling basis of ulceration is being elucidated.

179 The treatment of chronic mucocutaneous ulceration is challenging, and only some patients respon

180 eatment for Buruli ulcer, new or progressive ulceration is common before healing sets in.

181 al studies suggest that bleeding from stress ulceration is extremely uncommon in intensive care unit

182 Optimal management of digital ulceration is multidisciplinary including tissue viabili

183 errater reliability suggests that if digital ulceration is to be used as an end point in multicenter

184 tablish whether the unanticipated finding of ulcerations is specific to this tenofovir disoproxil fum

185 nel of nurses with advanced knowledge of leg ulceration judged the same scenarios and provided a stan

186 Age, MR, ulceration, LVI, regression, and sentinel node status we

187 o age, Breslow thickness, mitotic rate (MR), ulceration, lymphovascular invasion (LVI), and regressio

188 Moreover, they suggest that ulceration may be driven by increased glycolysis and ang

189 Extent of ulceration (measured either as diameter or percentage of

190 Disease progression can lead to corneal ulceration, melt, and perforation.

191 h as following surgery, biopsy collection or ulceration, might impact on cancer progression.

192 6-13.23]); other independent predictors were ulceration, mitoses, and scalp location.

193 lysis, age, growth phase, Breslow thickness, ulceration, mitotic rate, regression, and lymphovascular

194 , segment wall hyperenhancement (n=18), deep ulceration (n=6), fistula (n=3), stenosis (n=7), mesente

195 Nonsexual acute genital ulceration (NAGU) is a rare vulvar skin condition typica

196 ination revealed a painful lesion with focal ulceration, necrosis and pus discharge with active infla

197 were noted, including corneal opacification, ulceration, neovascularization, and ectasia.

198 increased risk for the development of peptic ulceration, noncardia gastric adenocarcinoma, and gastri

199 icobacter pylori is a risk factor for peptic ulceration, noncardia gastric adenocarcinoma, and gastri

200 ted after adjusting for maximum thickness or ulceration of any melanoma regardless of the index tumor

201 coronary syndromes related to thrombosis and ulceration of atherosclerotic plaque within a coronary a

202 neri experience severe inflammation, massive ulceration of the colonic mucosa, and bloody diarrhea.

203 However, massive ulceration of the colonic mucosa, bloody diarrhea, and d

204 BK is characterized by excessive tearing and ulceration of the cornea.

205 N0 M0 tumor that was 2.7 mm in depth with no ulceration of the epidermal surface.

206 A newborn girl presented with an ulceration of the left forearm associated with an appare

207 ital inflammation of either partner, genital ulceration of the man, and first follow-up interval.

208 because radiation causes fatal bleeding and ulceration of the nearby stomach and intestines before a

209 Ulceration of the oesophageal squamous mucosa (ulcerativ

210 lymph node staging procedure, Breslow depth, ulceration of the primary lesion, and disease stage.

211 umber of metastatic nodes, tumor burden, and ulceration of the primary melanoma.

212 2.90 mm; 95% CI, 2.87-4.54 mm; P = .54), or ulceration of the primary tumor (difference, -8.00%; 95%

213 N stage according to AJCC staging criteria, ulceration of the primary tumour, and patient sex.

214 A common feature of human wounds and ulcerations of any form is the expression of matrix meta

215 enucleation, and (iii) the impact of mucosal ulceration on outcome.

216 Acute laryngeal injury (i.e., mucosal ulceration or granulation tissue in the larynx) was pres

217 owth rate, and were increased in presence of ulceration or higher Clark levels.

218 No skin ulceration or nipple discharge was present.

219 analysis, endoscopic abnormalities, that is, ulceration or nodularity (P = 0.0002; relative risk [RR]

220 is administered to dogs with gastroduodenal ulceration or oesophagitis, whereas the neurokinin-1 rec

221 e measure was the odds of developing corneal ulceration or perforation in the first year.

222 nd vision-threatening corneal complications (ulceration or perforation) at presentation were evaluate

223 patients; large complex plaques (those with ulcerations or mobile components) were seen in 8.5%.

224 6.1; >4 mm: OR, 12.6; 95% CI, 7.5-21.1), and ulceration (OR, 2.0; 95% CI, 1.5-2.7).

225 lder than 75 years; had T1b tumors, no tumor ulceration, or head/neck or truncal lesions; were covere

226 f crypts and no crypt destruction, erosions, ulcerations, or granulation tissue) and clinical endpoin

227 xamethasone 0.1% 4 times daily), and corneal ulceration over the 4 months.

228 cal presentation characterized by a stellate ulceration over the upper extremities and reported assoc

229 eal scarring (P < .00001; OR: 3.00), corneal ulceration (P < .00001; OR: 12.96), low Schirmer values

230 Tumor thickness (P < .001), ulceration (P < .001), satellitosis (P < .001), mitotic

231 ), greater Breslow thickness (P < .001), and ulceration (P < .02).

232 (P < .001), decreasing TIL grade (P < .001), ulceration (P = .003), increasing tumor thickness (P = .

233 (P = .03), Clark level >/= IV (P = .05), and ulceration (P = .01) significantly predicted SLN metasta

234 However, pedunculated morphology (P < .007), ulceration (P = .026), depressed areas (P < .001), or no

235 body changes with posterior pharyngeal wall ulceration (P<.01).

236 icin is applied to skin surfaces at risk for ulceration, particularly in neuropathic conditions chara

237 /=2 mitoses/mm(2) (40 ulcerated; 289 without ulceration), patients with diabetes had significantly ra

238 Major gastrointestinal complications are ulceration, perforation, hemorrhage, and obstruction.

239 usted for age, Breslow thickness, body site, ulceration, performed lymph node dissection, and treatme

240 ment of the amount and type of inflammation, ulceration, perineural invasion, and depth of invasion).

241 The ulceration phenotype likely represents the genotype of t

242 ing for the large numbers of people with leg ulceration play a key role in promoting quality in healt

243 urgery; no diabetes and no venous edema with ulcerations postsurgery (either no history or remission)

244 performed to investigate the hypothesis that ulceration predicts improved response to adjuvant interf

245 er was 40 mm (18-65 mm), without any mucosal ulceration, preoperative capsular ruptures, or incomplet

246 ess more than 0.75 mm, MR >/= 1, presence of ulceration, presence of LVI, and regression >/= 50%.

247 t diabetes who developed neuropathic corneal ulceration presumed secondary to long ciliary nerve comp

248 cludes pulmonary hypertension, cutaneous leg ulceration, priapism, and ischemic stroke.

249 hose regions, and chemically induced colonic ulcerations promoted bacterial colonization.

250 4000 patients with a diagnosis of venous leg ulceration, prospectively recorded between the years 200

251 y of stomatitis, mucosal inflammation, mouth ulceration, rash, and fatigue.

252 greater than 2.00 mm in women, and relative ulceration rates (95% CI) declined in both sexes (EAPCs,

253 agrammatic questionnaire data to exclude leg ulceration reduced the rate to 10.76%.

254 the prognostic significance of the extent of ulceration remains unclear.

255 with intravascular hemolysis, cutaneous leg ulceration, renal insufficiency, iron overload, and live

256 caused corneal epithelial loss, and stromal ulceration resulting in decreased CCT.

257 The corneal ulceration's width and length was significantly bigger i

258 ek recovery period, colonic inflammation and ulceration scores returned to pretreatment levels compar

259 range, 79%-80%; herpes simplex virus, vulvar ulcerations: sensitivity, 20%; specificity, 98%; PPV, 88

260 ickness >/= 0.75 mm, Clark level >/= IV, and ulceration significantly predict SLN disease in thin mel

261 copy number was an independent predictor of ulceration status (P=0.04).

262 node-negative and node-positive patients by ulceration status revealed that the only significant imp

263 ed PHIP copy number and tumor vascularity on ulceration status was highly significant (P<0.0001).

264 ad no significant impact on OS regardless of ulceration status, however.

265 rates of < 5% regardless of Clark level and ulceration status.

266 of causing difficult-to-manage toxicity (eg, ulceration, stenosis, fibrosis, and even necrosis) that

267 smitted disease chancroid and a chronic limb ulceration syndrome in children.

268 neficial for the prevention of diabetic foot ulceration, the effect of foot self-care behavior on the

269 been recognized as being present in herpetic ulcerations, their role in subclinical reactivation and

270 ated with a large reduction in the hazard of ulceration, there was a high degree of uncertainty aroun

271 In addition to protection against stomach ulceration, these prodrugs exhibited significantly enhan

272 nes should consider the interaction among CM ulceration, thickness, sex, and age at diagnosis.

273 Colonoscopy revealed severe ulceration throughout the ascending and transcending col

274 with fistula formation (11.6%) and four with ulceration/tissue necrosis (9.3%).

275 ing validation, the point prevalence of foot ulceration was 3.39% and the overall prevalence was 9.73

276 The presence of ulceration was also an independent predictor of poorer M

277 Endoscopic mucosal ulceration was associated with more aggressive tumors.

278 Ulceration was associated with significantly worse DFS a

279 The baseline degree of mucosal ulceration was documented by ileocolonoscopy.

280 owever, a potentially fatal gastrointestinal ulceration was recently found and herein reported.

281 The incidence of tumor ulceration was stable across all tumor depths among youn

282 ables (patient age, Breslow depth, and tumor ulceration) was significantly greater than a model that

283 of observations of slowed tumor growth after ulceration, we hypothesized that full thickness excision

284 ific junctional pattern, basaloid cords, and ulceration were associated with basal cell carcinomas.

285 Both the presence and extent of ulceration were independent predictors of survival.

286 The most common sites for ulceration were the dorsal aspect of hammer toes, the me

287 istologically defined as mitoses/mm(2)), and ulceration were the most dominant prognostic factors.

288 No epithelial erythema, erosions, or ulcerations were seen.

289 f landmarks and visible lesions (nodularity, ulceration) when present.

290 . rodentium by protecting the mucosa against ulcerations which can act as a microbial niche for the b

291 ex, deeper Breslow thickness, and with tumor ulceration while decreasing with greater PSM (P < .001).

292 ctivity index (CDAI) scores >220 and mucosal ulcerations, who received open-label vedolizumab (300 mg

293 ickness of 4.8 mm, Clark level IV, and tumor ulceration with a mitotic rate of 37 mitoses/mm(2).

294 eocolonoscopy findings of extensive aphthous ulceration with skip lesions extending to the terminal i

295 analyzed (1311 without ulceration, 458 with ulceration) with a median follow-up of 71 months.

296 reduced the side effect of gastrointestinal ulceration without affecting anti-inflammatory activity,

297 satory proliferation in crypts and extensive ulcerations without significant changes in inflammatory

298 alopecia, epidermal hyperproliferation, and ulceration, without obvious effects on epidermal differe

299 f eosinophils (present vs absent; P = .007), ulceration (yes vs no; P = .003), perineural invasion (y

300 enotypic variables (e.g., depth of invasion, ulceration) yields a wide range of 10-year melanoma-spec