ライフサイエンスコーパス: unactivated

1 with blood ILC2s, whereas blood ILC2s remain unactivated.

2 ombin, a closely related serpin, essentially unactivated.

3 highly active catalyst for hydroboration of unactivated 1,2-disubstituted alkenes, a class of substr

4 Selective 1,4-difunctionalization of unactivated 1,3-dienes, such as butadiene, has been achi

5 s necessary for these reactions to occur, as unactivated 1-alkenyl-5-pentyn-1-ols fail to undergo 6-e

6 er/intramolecular double carboalumination of unactivated 2-substituted 1,5-dienes, which provides eff

7 PO3(2-), 2.5 +/- 0.1; S2O3(2-), 2.9 +/- 0.1; unactivated; 2.4 +/- 0.2.

8 these complexes: (1) transmetalation via an unactivated 6-B-3 intermediate that dominates in the pre

9 been developed utilizing synthetically inert unactivated acyclic internal olefins as allylic surrogat

10 to our knowledge, broadly applicable use of unactivated alcohols as latent alkylating reagents, achi

11 echanistic pathway in which the oxidation of unactivated alcohols is achieved by thiyl radical mediat

12 The direct, catalytic substitution of unactivated alcohols remains an undeveloped area of orga

13 enabling the direct coupling of ketones with unactivated alcohols.

14 nes to both beta-substituted vinylarenes and unactivated aliphatic alpha-olefins.

15 als generated by single-electron transfer to unactivated aliphatic amides; however, little variation

16 tric iron mediates the thioetherification of unactivated aliphatic C-H bonds directed by resident sil

17 the palladium-catalyzed direct arylation of unactivated aliphatic C-H bonds in free primary amines.

18 The selective functionalization of unactivated aliphatic C-H bonds over intrinsically more

19 Many enzymes oxidize unactivated aliphatic C-H bonds selectively to form alco

20 uplings between unsaturated hydrocarbons and unactivated aliphatic C-H bonds via a metal-hydride path

21 n-amidyl radicals remove hydrogen atoms from unactivated aliphatic C-H bonds.

22 for the selective late-stage modification of unactivated aliphatic carbon centers in small molecules

23 d olefins (activated acrylates and styrenes; unactivated aliphatic olefins) demonstrates the robustne

24 strate scope, in particular noncompliance of unactivated aliphatic olefins, has discouraged the use o

25 ctrophiles, there are few examples involving unactivated aliphatic substrates.

26 nation of phenylacetic acid derivatives with unactivated, aliphatic alkenes in good to excellent yiel

27 ange of intermolecular functionalizations of unactivated, aliphatic C-H bonds.

28 verse range of nitrogen-centered radicals in unactivated, aliphatic C-H chlorinations.

29 oride (COPC) can catalytically dehydrogenate unactivated alkanes and alcohols under near-UV irradiati

30 cy of this system also enables borylation of unactivated alkanes in hydrocarbon solvent with a reduce

31 The dehydrogenation of unactivated alkanes is an important transformation both

32 ngs of heteroarenes with ethers, amines, and unactivated alkanes with turnover numbers of 930, 790, a

33 ative dehydrogenative carboxylation (ODC) of unactivated alkanes with various substituted benzoic aci

34 The Ni-catalyzed oxidation of unactivated alkanes, including the oxidation of polyethy

35 The reaction of the unactivated alkene is completely selective for the forma

36 include a dioxygenase reactivity in which an unactivated alkene is converted to a vicinal diol.

37 intermolecular hydroamination of any type of unactivated alkene lacking a directing group occur with

38 lyst system allows us to reduce a variety of unactivated alkene substrates to their respective alkane

39 method for the difluorination of a number of unactivated alkene-types that is tolerant of electron-ri

40 much faster than the radical addition to an unactivated alkene.

41 alyzed intermolecular [2+2] cycloaddition of unactivated alkenes and cross cycloaddition of alkenes a

42 ficant aspects of the present method is that unactivated alkenes are suitable substrates for this met

43 photoredox catalyzed difluoromethylation of unactivated alkenes coupled with C-C bond formation to a

44 oselective methods enabling cyclization onto unactivated alkenes exist.

45 zed 1,2-dicarbofunctionalization reaction of unactivated alkenes has been developed, wherein a cleava

46 ions of a halogen and phosphoramidic acid to unactivated alkenes have been developed, catalyzed by a

47 of a nickel-catalyzed difunctionalization of unactivated alkenes initiated by an unstabilized enolate

48 anti-Markovnikov-selective hydroamination of unactivated alkenes is a significant challenge in organo

49 A copper-catalyzed aminoazidation of unactivated alkenes is achieved for the synthesis of ver

50 general method for the hydropyridylation of unactivated alkenes is described.

51 A palladium-catalyzed C-H iodination of unactivated alkenes is reported.

52 An intermolecular 1,2-carboamination of unactivated alkenes proceeding via a Pd(II)/Pd(IV) catal

53 II)-catalyzed regiodivergent oxyamination of unactivated alkenes provides valuable gamma-lactams, gam

54 or the synthesis of amines, but reactions of unactivated alkenes remain inefficient.

55 lkenes, and all the examples of additions to unactivated alkenes require large excesses of alkene.

56 sacrificial amine and a borane, even simple, unactivated alkenes such as 1-hexene undergo hydrogenati

57 nt atom transfer radical additions (ATRA) to unactivated alkenes to form chloro, difluoromethylated a

58 amine derivatives and alcohols onto pendant unactivated alkenes to provide a range of valuable satur

59 We report the first reductive coupling of unactivated alkenes with N-methoxy pyridazinium, imidazo

60 The intermolecular hydroamination of unactivated alkenes with simple dialkyl amines remains a

61 The efficient and catalytic amination of unactivated alkenes with simple secondary alkyl amines i

62 eport the first undirected hydroarylation of unactivated alkenes with unactivated arenes that occurs

63 conjugated polar alkenes, hydrosilylation of unactivated alkenes, and hydrodefluorination of fluoroal

64 ld with a wide variety of both activated and unactivated alkenes, including those containing free ami

65 s proceed under mild thermal conditions with unactivated alkenes, tolerating both amine and ether fun

66 not previously catalyzed such reactions with unactivated alkenes.

67 s for highly stereoselective arylboration of unactivated alkenes.

68 ition reaction between boron alkylidenes and unactivated alkenes.

69 alpha,beta-unsaturated carbonyl compounds to unactivated alkenes.

70 readily available acrylamide derivatives and unactivated alkenes.

71 selective oxyamination of both activated and unactivated alkenes.

72 or the intramolecular hydroetherification of unactivated alkenols to furnish cyclic ether products.

73 gent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereb

74 Pd-mediated one-pot ketone synthesis from an unactivated alkyl bromide and a thioester has been exten

75 -, sulfur-, or carbon-based nucleophiles and unactivated alkyl bromides (>130 examples, mostly >95:5

76 se reactions efficiently deliver esters from unactivated alkyl bromides across a diverse range of sub

77 atalyzed migratory 3,3-difluoroallylation of unactivated alkyl bromides at remote tertiary centers.

78 the palladium-catalyzed carbocyclization of unactivated alkyl bromides with alkenes is described.

79 ogues is demonstrated by cross-coupling with unactivated alkyl bromides, generating a diverse array o

80 )](2+) (2b) species capable of hydroxylating unactivated alkyl C-H bonds with stereoretention in a ra

81 les the first cross-electrophile coupling of unactivated alkyl chlorides and aryl chlorides.

82 ntermolecular cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowled

83 metal-catalyzed cross-coupling reactions of unactivated alkyl electrophiles are emerging as a powerf

84 alkenyl electrophiles, the cross-coupling of unactivated alkyl electrophiles containing beta hydrogen

85 Although the catalytic carboxylation of unactivated alkyl electrophiles has reached remarkable l

86 methods for the formation of C-C bonds from unactivated alkyl electrophiles have been described in r

87 lic carbenes (NHCs) has enabled reactions of unactivated alkyl electrophiles not only limited to the

88 B, C-Si and C-F bond-forming reactions using unactivated alkyl electrophiles.

89 oupling of an alkyl amine derivative with an unactivated alkyl group, and allows both primary and sec

90 via C-N bond activation of an amine with an unactivated alkyl group.

91 A catalytic C-H alkylation using unactivated alkyl halides and a variety of arenes and he

92 A Cu-catalyzed carbonylative silylation of unactivated alkyl halides has been developed, enabling e

93 copper-catalyzed carbonylative borylation of unactivated alkyl halides has been developed, enabling e

94 Carbonylations of unactivated alkyl halides remain a challenge and current

95 lyzed reductive cyclization/carboxylation of unactivated alkyl halides with CO2 is described.

96 that hydroalkylates unactivated olefins with unactivated alkyl halides, yielding aliphatic quaternary

97 sful with a variety of primary and secondary unactivated alkyl iodides as reaction partners, includin

98 lative C-C coupling of terminal alkynes with unactivated alkyl iodides has been developed, enabling h

99 method for C-alkylation of nitroalkanes with unactivated alkyl iodides is described.

100 ht-mediated late-stage aminocarbonylation of unactivated alkyl iodides with stoichiometric amounts of

101 eport a stereospecific aminocarbonylation of unactivated alkyl tosylates for the synthesis of enantio

102 cessible N-methoxybenzamide derivatives with unactivated alkynes for the synthesis of unusual 6,6-fus

103 e to functionalize a series of activated and unactivated alkynes in an entirely selective and predict

104 A regioselective anti-hydrochlorination of unactivated alkynes is reported.

105 a the conjugate addition of cyclic amines to unactivated alpha,beta-unsaturated esters.

106 ve sulfa-Michael addition of alkyl thiols to unactivated alpha-substituted acrylate esters catalyzed

107 aldehyde, ketone, activated ester/amide, and unactivated amide consist of two different rate limiting

108 modeled in a system possessing an otherwise unactivated amide positioned between two carboxy groups.

109 rst base metal-catalyzed alpha-alkylation of unactivated amides and esters by alcohols.

110 des direct access to acyl-type radicals from unactivated amides under mild electron transfer conditio

111 nyl)urea (10a) as a potent inhibitor against unactivated and activated c-KIT.

112 alytic intermolecular reductive couplings of unactivated and activated olefin-derived nucleophiles wi

113 n reactivity with factors Xa and IXa in both unactivated and heparin-activated states, indicating tha

114 e of a readily available amine source (DPH), unactivated and styrene-type olefins can now be stereosp

115 ith HBpin, pin = pinacolato) of a variety of unactivated, and sometimes very bulky, carbonyl compound

116 Key steps in the functionalization of an unactivated arene often involve its dihaptocoordination

117 ategy for the direct trifluoromethylation of unactivated arenes and heteroarenes under either ultravi

118 -molecular direct C((sp)(2))-H arylations of unactivated arenes in a single representation.

119 of arynes from acyclic building blocks with unactivated arenes in intra- and intermolecular manners

120 -molecular direct C((sp)(2))-H arylations of unactivated arenes in the presence of potassium tert-but

121 The direct arylation of unactivated arenes is a very practical and highly conven

122 processes for Friedel-Crafts alkylations of unactivated arenes is an important objective of interest

123 uce a solvated electron for the reduction of unactivated arenes such as benzene (E(red) < -3.42 V vs

124 d hydroarylation of unactivated alkenes with unactivated arenes that occurs with high regioselectivit

125 ich facilitates the C-H functionalization of unactivated arenes to form the biaryl products.

126 vious studies have reported the arylation of unactivated arenes with ArX, base (KO(t)Bu or NaO(t)Bu),

127 increased activity for the C-H borylation of unactivated arenes.

128 s highly modular vinyl cyclic carbonates and unactivated aromatic amine nucleophiles as substrates.

129 earth-metal complexes allows the cleavage of unactivated aromatic C-H bonds.

130 tions between a variety of alkyl halides and unactivated aryl boronic esters using a rationally desig

131 g aryldiphosphine ligand, to oxidatively add unactivated aryl chlorides at room temperature.

132 port a one-step procedure to directly reduce unactivated aryl esters into their corresponding tolyl d

133 he electrophotocatalytic S(N) Ar reaction of unactivated aryl fluorides at ambient temperature withou

134 ither the chemical mechanisms by which these unactivated atoms obtain methyl groups nor the actual me

135 ulting from the thermal C-C bond cleavage of unactivated aziridines with beta-bromo-beta-nitrostyrene

136 Recently, a direct arylation of unactivated benzene has been achieved in the presence of

137 While the inter-molecular C-H arylation of unactivated benzenes with aryl halides (Ar-X; X = I, Br,

138 lass of simple ketones possessing chemically unactivated beta sites, with arylboronic acids via tande

139 remote alkenylation of aliphatic alcohols at unactivated beta-, gamma-, and delta-C(sp(3) )-H sites.

140 ted regioselective Csp(3)-H arylation of the unactivated beta-methylene bond of beta-alanine.

141 dy identifies a key aspect of DC biology: an unactivated BMDC is CD37(hi)CD82(lo), resulting in a hig

142 Pentafluoroethylation of unactivated C(sp(2))-X bonds (X = I, Br) using a storabl

143 The fluorination of unactivated C(sp(3) )-H bonds remains a desirable and ch

144 nsfer, for the directed functionalization of unactivated C(sp(3) )-H bonds.

145 C(sp(3))-H bond of toluene and a completely unactivated C(sp(3))-H bond of cyclohexane demonstrate t

146 carbenoid chemistry, i.e., insertion into an unactivated C(sp(3))-H bond, has not be realized.

147 regioselective C(sp(3))-C(sp(3)) coupling of unactivated C(sp(3))-H bonds and alkyl bromides.

148 The direct, site-selective alkylation of unactivated C(sp(3))-H bonds in organic substrates is a

149 ymene)](2)-catalyzed direct monoarylation of unactivated C(sp(3))-H bonds of 8-methyl quinolines with

150 The functionalization of unactivated C(sp(3))-H bonds poses a significant challen

151 is for the selective activation of otherwise unactivated C(sp(3))-H bonds, followed by their trifluor

152 proach to the catalytic functionalization of unactivated C(sp(3))-H bonds.

153 talyzed method for the borylation of remote, unactivated C(sp(3))-H bonds.

154 g evidence to support such reactivity toward unactivated C(sp(3))-H bonds.

155 The HAT at unactivated C(sp(3))-H sites is enabled by the easily in

156 This work constitutes an example of the unactivated C(sp(3))-SCF3 bond formation by C-H activati

157 kable because the reactions must occur at an unactivated C-H bond over functional groups that are mor

158 orm C-C bonds or install functionality at an unactivated C-H bond will be presented, and the potentia

159 ds to intramolecular carbene insertions into unactivated C-H bonds and intermolecular carbene inserti

160 investigations of Ni-catalyzed oxidations of unactivated C-H bonds by mCPBA.

161 ions based on catalytic functionalization of unactivated C-H bonds has the potential to simplify the

162 d to catalyze regioselective halogenation of unactivated C-H bonds in bacteria, they remain uncharact

163 ate high valent iron-oxo species to homolyze unactivated C-H bonds in substrates to initiate skeletal

164 f nitrogen-containing functional groups into unactivated C-H bonds is not catalyzed by known enzymes

165 methods for the direct functionalization of unactivated C-H bonds is ushering in a paradigm shift in

166 ected fluorination of benzylic, allylic, and unactivated C-H bonds mediated by iron.

167 erization from a variety of ethers, alkanes, unactivated C-H bonds, and alcohols.

168 Selective functionalization of unactivated C-H bonds, water oxidation, and dioxygen red

169 mical strategy for the homolytic cleavage of unactivated C-H bonds.

170 ivation, discrimination between two similar, unactivated C-H positions is beyond the scope of current

171 A Ni/Cu-catalyzed silylation of unactivated C-O electrophiles derived from phenols or be

172 zes the insertion of two sulfur atoms at the unactivated C6 and C8 positions of a protein-bound octan

173 A practical three-component reaction between unactivated carbohydrates, oxoacetonitriles, and ammoniu

174 methylases perform methylation reactions at unactivated carbon and phosphorus atoms.

175 installs an aliphatic ether cross-link at an unactivated carbon center, linking the oxygen of a Thr s

176 ine (rSAM) methyltransferases that methylate unactivated carbon centers.

177 step involves the electrophilic attack of an unactivated carbon dioxide unit on a metal-sigma-acetyli

178 dical SAM (RS) enzymes is the methylation of unactivated carbon or phosphorous atoms found in numerou

179 insertion of one atom of oxygen from O2 into unactivated carbon-hydrogen and carbon-carbon bonds, wit

180 ion involving a covalent linkage between two unactivated carbons within the side chains of lysine and

181 s observed being conserved, in comparison to unactivated complex, after trapping.

182 gly more electron-deficient arene before the unactivated "control" ring undergoes monobromination.

183 xes enables Suzuki-Miyaura cross-coupling of unactivated Csp(3) boronic acids with perfect stereorete

184 normally unreactive azadienophiles including unactivated cyano groups and heterosubstituted imine der

185 nalization remains difficult, especially for unactivated cyclopropanes.

186 ed by iridium-catalysed C-H silylation of an unactivated delta-C(sp(3))-H bond to produce a silolane

187 acrocyclic carbon-carbon bond that links the unactivated delta-carbon of an arginine side chain to th

188 al electron-demand [4 + 2] cycloadditions of unactivated dialkylhydrazones are unprecedented.

189 lecular hetero-Diels-Alder reaction features unactivated dienophiles and o-QM precursors tethered by

190 for the cis-bis(silyl)ation of alkynes using unactivated disilanes is reported.

191 re able to overcome the reactivity issues of unactivated enamides, known as the least reactive carbox

192 especially challenging alkylation is that of unactivated esters and amides.

193 y for the challenging CH substrates, such as unactivated esters and carboxylic acids.

194 zed beta-ketophosphonates in the presence of unactivated esters with high yields.

195 converted readily to enantioenriched amides, unactivated esters, and carboxylic acids in a one-pot ma

196 echanistic investigation of the reduction of unactivated esters, carboxylic acids, and amides using S

197 ethod for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accel

198 is distinguished by a wide scope, including unactivated fluoroarenes, without compromising its effic

199 Both activated and unactivated free amines were oxygenated efficiently to p

200 ple those requiring (18)F incorporation into unactivated (hetero)arenes.

201 ctive mono-alkylation of aliphatic amines by unactivated, hindered halides persists as a largely unso

202 ntered radical that undergoes addition to an unactivated imine, leading to an N-centered radical.

203 dition of an aryl pinacolboronic ester to an unactivated imine.

204 agents, as well as O-H and C-H bonds, across unactivated internal alkenes to streamline the synthesis

205 ctive and E/Z-selective allylic oxidation of unactivated internal alkenes via a catalytic hetero-ene

206 ct addition of the N-H bond of amines across unactivated internal alkenes(5-7), including photocataly

207 enabling the catalytic hydrophosphination of unactivated internal alkynes.

208 zed hydroamination that effectively converts unactivated internal olefins-an important yet unexploite

209 rtion by overcoming inertness of the typical unactivated internal olefins.

210 intermolecular hydroamination of a range of unactivated, internal alkenes, including those in both a

211 bridged, and spirocyclic ring systems using unactivated ketone and alkene precursors.

212 groups chemoselectively to a wide variety of unactivated ketone compounds via their enone counterpart

213 Enzyme catalysed PSRs with unactivated ketones are unprecedented, and, furthermore,

214 etric aldol addition/cyclization reaction of unactivated ketones with isocyanoacetate pronucleophiles

215 S) can catalyse the PSR between dopamine and unactivated ketones, thus facilitating the facile biocat

216 engineering, and applied to the oxidation of unactivated methylene C-H bonds.

217 the C-H bonds of beta-methyl groups over the unactivated methylene C-H bonds.

218 between the two enantiotopic C-H bonds of an unactivated methylenic group is particularly demanding a

219 method for the Ni-catalyzed arylboration of unactivated monosubstituted, 1,1-disubstituted, and tris

220 h enantioselectivities to both activated and unactivated nitroalkenes.

221 tion, and alpha-alkylation/alkenylation with unactivated olefins and alkynes.

222 ity in the room-temperature hydrogenation of unactivated olefins and were found to be significantly m

223 y catalyze the hydrogenation of a variety of unactivated olefins at 100 degrees C.

224 sulfonates as alkylating agents, the use of unactivated olefins for alkylations has become attractiv

225 ive oxidative rearrangement of disubstituted unactivated olefins has been achieved using a hypervalen

226 alyst-free, and metal-free bromoamidation of unactivated olefins has been developed.

227 We present a strategy that difunctionalizes unactivated olefins in 1,2-positions with two carbon-bas

228 n of hydrazoic acid across a wide variety of unactivated olefins in both complex molecules and unfunc

229 A catalytic deaminative alkylation of unactivated olefins is described.

230 -catalyzed oxidative coupling of furans with unactivated olefins to generate branched vinylfuran prod

231 tem for the intramolecular hydroamidation of unactivated olefins using simple N-aryl amide derivative

232 New advances in the functionalization of unactivated olefins with carbon nucleophiles have provid

233 molecular anti-Markovnikov hydroamination of unactivated olefins with primary alkyl amines to selecti

234 We report a series of hydroarylations of unactivated olefins with trifluoromethyl-substituted are

235 Ni dual catalytic system that hydroalkylates unactivated olefins with unactivated alkyl halides, yiel

236 Unactivated olefins, featuring a wide range of functiona

237 ramolecular ketone alkylation reactions with unactivated olefins, resulting in Conia-ene-type reactio

238 I) hydride (CuH)-catalyzed hydroamination of unactivated olefins, the substantially enhanced reactivi

239 r anti-Markovnikov hydroazidation method for unactivated olefins, which is promoted by a catalytic am

240 - and diastereoselective cyclopropanation of unactivated olefins.

241 highly electron-rich heteroaryl bromides and unactivated olefins.

242 d CaMKII holoenzymes to exchange dimers with unactivated ones.

243 lboronic acids, potassium metabisulfite, and unactivated or activated alkylhalides is described.

244 ul method for selective functionalization of unactivated or intrinsically less reactive C-H bonds.

245 of carbon-based nucleophiles to unprotected/unactivated (or N-H) ketimines.

246 ntramolecular direct C(sp(3))-H amination of unactivated organic azides to generate a range of satura

247 m produced water relying on the oxidation by unactivated peroxymonosulfate.

248 dding to the model binding and activation of unactivated platelets through von Willebrand-factor-medi

249 not constitutively associated with talin in unactivated platelets, but becomes bound to talin in res

250 roduces unnatural beta-thioether linkages at unactivated positions.

251 A Ni-catalyzed carboxylation of unactivated primary alkyl bromides and sulfonates with C

252 ming process is successful with a variety of unactivated primary and secondary alkyl halides, includi

253 ategy developed for the functionalization of unactivated primary beta C-H bonds of aliphatic amines.

254 is associated with selective oxygenation of unactivated primary C-H bonds.

255 A catalytic carboxylation of unactivated primary, secondary, and tertiary alkyl chlor

256 -catalyzed process for the cross coupling of unactivated primary, secondary, and tertiary alkylcarbas

257 ch allows for the borylation of activated or unactivated primary, secondary, and tertiary bromides.

258 ))-H amination of 1,2,3,4-tetrazoles bearing unactivated primary, secondary, and tertiary C-H bonds i

259 ntioselective intramolecular, silylations of unactivated, primary C(sp(3))-H bonds.

260 patterns over all trapping times studied for unactivated protein complexes, suggesting that any confo

261 EK first delivered unactivated PS throughout the silt.

262 A broad range of unactivated pyridines can be halogenated, and the method

263 An unprecedented intramolecular acylation of unactivated pyridines via multiple C(sp(3)/sp(2))-H func

264 y able to catalyze direct dearomatization of unactivated pyridines with carbon nucleophiles, but the

265 upling of a range of primary carbamates with unactivated secondary alkyl bromides at room temperature

266 rmation, specifically, that the cyanation of unactivated secondary alkyl chlorides can be achieved at

267 of coupling a carbamate nucleophile with an unactivated secondary alkyl electrophile to generate a s

268 atic amines can be cleanly mono-alkylated by unactivated secondary alkyl iodides in the presence of v

269 ess for the stereospecific cross-coupling of unactivated secondary alkylboron nucleophiles and aryl c

270 de THF, while the alkylation works well with unactivated secondary bromides and iodides in 2-methylte

271 It can cleave benzylic and unactivated secondary C-H bonds, but exhibits unique sel

272 ereoretentive cross-coupling with a range of unactivated secondary Csp(3) boronic acids, as well as t

273 eports of metal-catalyzed cross-couplings of unactivated secondary or tertiary alkyl halides with sil

274 Additionally, sp(3) C-H bonds of unactivated secondary sp(3) C-H bonds could be functiona

275 The Cdelta -H amination of unactivated, secondary C-H bonds to form a broad range o

276 ced by a 9-12-membered ring, were made by an unactivated Smiles rearrangement of five- to eight-membe

277 e C-methylation of thiazole, occurring at an unactivated sp(2) carbon.

278 ide-directed selective C-C bond formation at unactivated sp(3) C-H bonds in molecules that contain ma

279 ment of visible-light-mediated allylation of unactivated sp(3) C-H bonds is reported.

280 The direct functionalization of unactivated sp(3) C-H bonds is still one of the most cha

281 The direct alkylation of unactivated sp(3) C-H bonds of aliphatic amides was achi

282 e direct carbonylation of aromatic sp(2) and unactivated sp(3) C-H bonds of amides was achieved via n

283 , a palladium-catalyzed functionalization of unactivated sp(3) C-H bonds with internal alcohol nucleo

284 intermolecular dehydrogenative amination of unactivated sp(3) carbons is also realized.

285 via a C-H bond functionalization process on unactivated sp(3) carbons with the assistance of a biden

286 groups that can be introduced, especially at unactivated sp(3)-hybridized positions.

287 egy for sulfur incorporation into completely unactivated substrates.

288 The regioselectivity of the reaction with unactivated terminal alkene is significantly improved by

289 roach to pyrrolidines from readily available unactivated terminal alkenes as 4-carbon partners.

290 termolecular hydroaminations of a variety of unactivated terminal alkenes without the need for an exc

291 ve Rh-catalyzed Markovnikov hydroboration of unactivated terminal alkenes.

292 at promote the unique [2+2] cycloaddition of unactivated terminal alkenes.

293 f alpha-functionalized ketones containing an unactivated terminal alkyne and produces an exo-methylen

294 directed, regiocontrolled hydroamination of unactivated terminal and internal alkenes is reported.

295 pecially noteworthy is our ability to employ unactivated tertiary alkyl halides as electrophilic coup

296 , and tertiary benzylic fluorides as well as unactivated tertiary fluorides, that are typically inacc

297 ng out cascade Heck-type reactions involving unactivated (tertiary) alkyl halides remains an unmet ch

298 Crabtree's catalyst in the hydrogenation of unactivated trisubstituted olefins and superior activity

299 A GES device was implanted and left unactivated until patients were randomly assigned, in a

300 romethylation of activated, carbocyclic, and unactivated vinylcyclopropanes via a ring-opening reacti