ライフサイエンスコーパス: unanticipated

1 ) disulfide link, although the bond angle is unanticipated.

2 itis [unanticipated], and metabolic surgery [unanticipated]).

3 highlight, through a series of examples, the unanticipated ability of the Day/Night Band (DNB) on the

4 w that certain HIV-1 envelope genes have the unanticipated ability to resist specific human defenses

5 Here, we report an unanticipated activity of yeast and human Rad52: inverse

6 No unanticipated adverse events were observed.

7 unctional impairment of this enzyme leads to unanticipated adverse reactions and therapeutic failures

8 These data point to a previously unanticipated and conserved role for TRAPPC11 in LLO bio

9 The lack of effect with universal ART was unanticipated and not consistent with the data on viral

10 Stimulated CNV therefore represents an unanticipated and remarkably controllable pathway facili

11 Here, we discovered an unanticipated and sole role for spermine in facilitating

12 icle highlights a few select examples of the unanticipated and substantial positive spin-offs of HIV/

13 al infarction [anticipated], diverticulitis [unanticipated], and metabolic surgery [unanticipated]).

14 had a relatively unique ACAR, which included unanticipated antibodies to carbohydrate antigens not we

15 ften leads to unprecedented performance, and unanticipated applications.

16 The enzyme adopts an unanticipated architecture in which the C-terminal cyste

17 The eukaryotic core replisome shows an unanticipated architecture, with one polymerase sitting

18 Our work dissects unanticipated aspects of the cellular and molecular basi

19 ogether, our results suggest that previously unanticipated avenues may exist for design of self-assem

20 we reveal a novel role for neurexin-3alpha, unanticipated based on alpha-neurexin knock-out models,

21 matory phenotype and therefore could provide unanticipated benefit.

22 Together, our results reveal the unanticipated bifunctional role of VDAC2 to target Bax s

23 elevant environments, and tasks that involve unanticipated biological events.

24 anges in predator communities in stimulating unanticipated biological trends that run contrary to exp

25 d animal biosynthetic enzymes that reveal an unanticipated breadth and intricacy in animal secondary

26 In the end, if we assume neither unanticipated breakthroughs in typhoid control nor any c

27 2, and 4-7)-an attributional pattern that is unanticipated by sharers (study 3), that persists days a

28 ndencies on proteostasis networks to uncover unanticipated cancer vulnerabilities.

29 dent hematopoietic lineages and establish an unanticipated capacity of megakaryocytes to mediate IL-1

30 onditions, and preparation for responding to unanticipated cardiac events in athletic venues.

31 itride nanotubes exhibit unique and hitherto unanticipated catalytic properties, resulting in great s

32 Our findings demonstrate an unanticipated cell-autonomic and circuit-independent dis

33 Here, we report an unanticipated cell-death- and inflammation-independent f

34 but a substantial obstacle is the myriad of unanticipated cellular responses in heterogeneous real-w

35 visit after cataract surgery, defined as an unanticipated change in postoperative drops, additional

36 Consequently, dose dumping or unanticipated changes in the LNG-IUS in vivo release cha

37 apped potential inherent in entirely new and unanticipated chemical subspaces offered by organometall

38 We identified two unanticipated classes of synapses, KC>DAN and DAN>MBON.

39 ico modeling of motif determinants uncovered unanticipated CN interactors, including NOTCH1, which we

40 vivo imaging of regenerating skin and reveal unanticipated collective dynamism in epithelial cell siz

41 These findings reveal unanticipated communication between stress-induced neura

42 These data reveal unanticipated complementary functions of NMIIA and NMIIB

43 abled the global mapping of TIs and revealed unanticipated complex translational landscapes in metazo

44 At the same time, they reveal unanticipated complexities in the interactions of M with

45 ion initiation complexes on active mRNAs and unanticipated complexity in stress granule composition.

46 These results reveal unanticipated complexity in the mutual regulation of the

47 in modifying T-cell function that highlights unanticipated complexity of intercellular communication

48 nd binding preferences of IDH1, revealing an unanticipated complexity of RNA regulation in diverse ce

49 Altogether, we reveal a previously unanticipated complexity of the developing ovary and pro

50 tant metabolic network for tumorigenesis, of unanticipated complexity, and with implications in the c

51 Unanticipated concerns emerged from countries over accep

52 echanism allows for response to a variety of unanticipated conditions.

53 Unanticipated conformations solved for complexes with co

54 Our study makes an unanticipated connection between stomatal regulation and

55 These unanticipated connections between disturbance, coral sym

56 An unanticipated consequence of this acidification mitigati

57 terventions that inhibit Siglec-7 could have unanticipated consequences and promote eosinophilic infl

58 These results reveal unanticipated consequences of delaying CRY degradation,

59 m to study mechanisms that may contribute to unanticipated consequences of injury, such as tumorigene

60 These studies unmask an unanticipated, conserved regulatory mechanism in HGP and

61 We discover unanticipated continuous changes in FRET with applied to

62 adoptive T cell-based immunotherapy, with an unanticipated cooperative antitumor effect of LDH inhibi

63 Our work reveals an unanticipated critical role of gammadelta-T cells in the

64 cated, labor-intensive, and often results in unanticipated crosstalk.

65 bt affects behavior by studying how a large, unanticipated debt-relief program affected psychological

66 Thus, our study identifies an unanticipated dependence of liver regeneration on MICU1

67 the HECT domain ligase Smurf2, leads to the unanticipated depletion of E2 approximately Ub and thus

68 cate that defects in such receptors may have unanticipated developmental consequences.

69 What have been the unanticipated developments?

70 The unanticipated difference in behavior between the open- a

71 lasm-membrane interface and reveal large and unanticipated differences among these residues.

72 cover unexpected chemical transformations or unanticipated differences in metabolic pathway activitie

73 1.25-2.88), and a 38% increase in odds of an unanticipated discharge to higher-level care (95% CI 1.1

74 Our unanticipated discovery highlights the importance of det

75 Target identification led to the unanticipated discovery that inhibition of the enzyme di

76 t safety or support system resilience during unanticipated disturbances in care were identified.

77 resilience of individuals or populations to unanticipated disturbances, and we find that resilience

78 Our data reveal unanticipated diversity in recognition sequences for cha

79 d single-cell transcriptomics, we uncover an unanticipated diversity of glial progenitor pools with u

80 The CEH-60:UNC-62 heterodimer serves an unanticipated dual function in intestinal nuclei by dire

81 sing a gfp-tagged allele of tra-1, we reveal unanticipated dynamics of TRA-1 protein expression in fi

82 Our work explains the unanticipated dynamics that eco-evolutionary feedbacks c

83 However, because of the unanticipated early termination of the trial, it is not

84 This unanticipated effect of miRNAs largely prevents short-ta

85 Because of this unanticipated effect, we used piecewise linear regressio

86 ith the use of multiple strains and possible unanticipated effects of natural polymorphisms.

87 tion, with altered dosR expression revealing unanticipated effects on bacterial survival during hypox

88 ealed that GNE deficiency is associated with unanticipated effects on the structure of cell-surface g

89 The unanticipated ensemble of flexible conformations of the

90 ch may restrict a cell's ability to adapt to unanticipated environmental challenges.

91 e surveys that are unable to detect rapid or unanticipated environmental changes.

92 HDACi treatment reveals unanticipated epigenomic plasticity in SCV relationships

93 Serious unanticipated events were studied including unplanned re

94 arts to be quickly exchanged in the event of unanticipated experimental difficulties, such as cloggin

95 In 2014, Western Africa experienced an unanticipated explosion of Ebola virus infections.

96 ial genomes, deep resequencing has uncovered unanticipated extreme genetic variation within mitochond

97 The model predicted an unanticipated feedback loop, whereby Raf/MEK/ERK signall

98 studies are needed to establish whether the unanticipated finding of ulcerations is specific to this

99 s in neuroimaging techniques have led to the unanticipated finding that dopaminergic dysfunction in s

100 Cytokine priming was required to elicit the unanticipated finding that Siglec-8 engagement promotes

101 In an unanticipated finding, metal-ion coordination was also f

102 arch is needed to determine reasons for this unanticipated finding.

103 This unanticipated flavin chemistry is not restricted to Etf-

104 These findings suggest an unanticipated function for parasite lysosomal degradatio

105 Here we show a hitherto unanticipated function of MCM2 in cilia formation in hum

106 graphene films may also offer an additional unanticipated function: mosquito bite protection for lig

107 r our model and experimental results suggest unanticipated functional benefits and costs of adaptatio

108 Our results reveal an unanticipated functional interplay between the RAG compl

109 Our findings uncover an unanticipated functional plasticity of the mRNA decappin

110 ation of inter-organ communications that are unanticipated, functionally important, and would have be

111 ovides an updated view of new and previously unanticipated functions of complement and how these affe

112 phenotypes of these pex alleles may reflect unanticipated functions of the peroxisomal ATPase comple

113 veloped melanoma-associated retinopathy with unanticipated fundus findings while receiving treatment

114 Host nuclear DNA further indicated unanticipated gene flow through the Andes mountains conn

115 edge of potential key regulators and reveals unanticipated gene network dynamics that drive cell fate

116 cepts might help improve outcome and prevent unanticipated harm.

117 This deep phenotyping has revealed unanticipated heterogeneity of clinical features, betwee

118 Here we report unanticipated heterogeneity within the Lgr5+ ISC pool.

119 of mutations in normal tissue, revealing an unanticipated high level of age-related somatic mutation

120 observed ciliogenesis defects and provide an unanticipated, highly conserved link between PAM, amidat

121 ned outcome (i.e., death, cardiac arrest, or unanticipated ICU admission) was 0.88 (0.88-0.88).

122 data and safety monitoring board detected an unanticipated imbalance across blinded groups in the num

123 These results identify an unanticipated immune evasion strategy of Mtb in the BM t

124 Here we report an unanticipated impact of intratumor heterogeneity (ITH) o

125 could not rule out batch effects due to the unanticipated impact of wAnga on oviposition timing.

126 or MDSC-mediated immunosuppression that have unanticipated implications for systemic cancer immunity.

127 n combined with l-DOPA treatment produced an unanticipated improvement in working memory performance,

128 DNA binding leads to an unanticipated increase in methyl side-chain flexibility

129 The ability to respond to unanticipated increases in volume is a fundamental prope

130 mozygous gene disruption mutants revealed an unanticipated, inhibitory role for the yeast-to-hypha mo

131 redictive models can enhance the salience of unanticipated input.

132 Collectively, our data reveal unanticipated insights regarding the serological respons

133 When unanticipated insults breach epithelial barriers, dorman

134 Complex and unanticipated interactions between manufacturer-specific

135 Due to the complexity of natural systems, unanticipated interactions may lead to erroneous conclus

136 usly uncharacterized TERT domain (TRAP) with unanticipated interactions with the telomerase essential

137 llectively, our results reveal an important, unanticipated interplay between CTCF and nuclear lamina

138 Here, we reveal an unanticipated interplay between the macrodomain and the

139 formation predominates (70%) and features an unanticipated intramolecular collapse of Tyr(93) in krin

140 s, but the later response is dominated by an unanticipated, ISG15-dependent loss of translational con

141 These efforts reveal a number of unanticipated issues of reactivity and significant stere

142 plying failed phosphate-steering promotes an unanticipated lagging-strand template-switch mechanism d

143 in pharmaceuticals and minimize the risk of unanticipated late-appearing polymorphs.

144 Our report shows that previously unanticipated, late, severe relapses of Ebola virus can

145 Our study identifies an unanticipated layer of Hippo pathway regulation, defines

146 Our results demonstrate an unanticipated level of control in insect acoustic commun

147 ovided by VRE-dominated patients revealed an unanticipated level of VRE population complexity that ev

148 was withdrawn from the market because of an unanticipated life threatening adverse effect: progressi

149 Here we uncover an unanticipated link between ADARs (ADAR1 and ADAR2) and t

150 Here, we report an unanticipated link between bone marrow and brain in the

151 One unanticipated major focus has been investigating the che

152 d that extrachromosomal circular DNAs are an unanticipated major source of somatic rearrangements, co

153 glycans can influence binding selectivity in unanticipated manners.

154 These findings suggest an unanticipated mechanism by which GNE activity might affe

155 Here, we elucidate an unanticipated mechanism for CXCL4-mediated immune amplif

156 ar occupancy of the cell, thus suggesting an unanticipated mechanism for cytosol homeostasis during c

157 biquitous RNA-binding proteins, revealing an unanticipated mechanism for heritable gene silencing.

158 Our data suggest an unanticipated mechanism of developmental compensation wh

159 These results identify an unanticipated mechanism regulating amino acid metabolism

160 may mediate cell-autonomous host defense, an unanticipated mechanism that is distinct from LC3B lipid

161 hifted invertebrate assemblage structure via unanticipated mechanisms, while still conforming to comm

162 Together these observations reveal unanticipated mechanistic ties between two distinct form

163 ng avenues toward the assembly of previously unanticipated metal-organic capsules, for example offeri

164 We encountered unanticipated methodological challenges with this trial

165 against a predefined glycan library owing to unanticipated modifications.

166 east ISW1 chromatin remodeling complex as an unanticipated mRNP nuclear export surveillance factor th

167 More broadly, this work highlights an unanticipated multi-functional role for IDRs in regulati

168 rect insertion of the donor cassette without unanticipated mutational events is much higher.

169 Unanticipated mutational hotspots caused experimental ob

170 This unanticipated nonhierarchical folding mechanism was dire

171 human brain cancer progression and reveal an unanticipated Notch-mediated function of Norrin in regul

172 ptic gain-of-function phenotype and revealed unanticipated novel insights into how alpha-neurexin ext

173 r pathogenesis, uncovering alterations in an unanticipated number of genes and regulatory elements.

174 An unanticipated observation from these studies is proregen

175 These unanticipated observations indicate that, during cold re

176 Torcetrapib was withdrawn due to unanticipated off-target effects that increased risk of

177 orms have proven functional, all can produce unanticipated off-target lesions and have difficulty dis

178 These results establish and elucidate the unanticipated oncogenic function of RUNX1 in AML.

179 y for restoring RNAi to zebrafish and reveal unanticipated opposing effects of a seed mismatch with i

180 nuclear body formation-G1 arrest axis as an unanticipated outcome of homologous recombination defici

181 rphous and amyloid protein aggregation is an unanticipated outcome of such stress.

182 ractions among these pathogens could mediate unanticipated outcomes of clinical interventions, includ

183 Analysis of independent datasets shows an unanticipated overlap between DNA methylation and chroma

184 One of these pathways involves an unanticipated oxygen-nitrogen exchange of the sulfonamid

185 elective chromosome condensation provides an unanticipated paradigm for antimicrobial action that may

186 s for substrate recognition and cleavage, an unanticipated parallel in their mode of action.

187 Here, we report several unanticipated passive and active properties of the cereb

188 ls can identify new immunotherapy targets in unanticipated pathways.

189 s, LFP-aligned oscillatory spiking, and even unanticipated patterns, such as 7 Hz oscillations in rat

190 Such treatments may however cause additional unanticipated phenomena which may affect wheat bran tech

191 The unanticipated phenotypic outcomes elicited by neomorphic

192 ary innate immunity, these studies elucidate unanticipated physiological functions for Piwi proteins

193 Thus, unanticipated plasticity in death pathways is revealed w

194 This study reveals an unanticipated plasticity of the adult skin epithelium wh

195 otomy, patients were deemed ineligible if an unanticipated pneumonectomy was indicated, or if air lea

196 canonical SH2 pY site while pS1493 binds an unanticipated pocket 70 A distant.

197 This was a natural experiment using the unanticipated pollution event by comparing the prevalenc

198 An unanticipated positive trend of the indicator from 2003

199 Here, we discovered in human neurons an unanticipated presynaptic mechanism that acutely changes

200 m the 1000 Genomes Project, we highlight the unanticipated prevalence of mistranslating tRNA variants

201 The chimeric circuit therefore reveals unanticipated principles of circuit-level operation unde

202 et, these structures are expected to exhibit unanticipated properties due to their size, compactness,

203 trameric chromatin-bound NRs, and previously unanticipated protein-protein/protein-DNA interactions.

204 xamples of unexpected acid-base behavior and unanticipated proximity-induced reactivity accounted for

205 rom active to inactive can originate from an unanticipated RANKL immunoregulatory feedback, involving

206 alpha-scorpion toxins, AaH2 also targets an unanticipated receptor site on VSD1 and a pore glycan ad

207 Our findings suggest an unanticipated reciprocal relationship between ciliation

208 identification of a close margin (n = 1) and unanticipated regions of primary disease (n = 2).

209 ng close or positive margins and visualizing unanticipated regions of primary disease.

210 Our results uncover an unanticipated regulatory circuit involving broad epigene

211 ll resolution of 3.8 angstrom), revealing an unanticipated regulatory mechanism where a loop distantl

212 Our data suggest an unanticipated regulatory network linking translational c

213 This cross-species approach identified unanticipated regulatory networks in mesodermal cells wi

214 We conclude that nucleoporins play an unanticipated regulatory role in NEBD, by recruiting PLK

215 cRNAs during fibrosis suggests they may have unanticipated regulatory roles.

216 Our data reveal an unanticipated requirement for the NSD pathway during oxi

217 thal interactions and the swift emergence of unanticipated resistance mechanisms to otherwise effecti

218 Unanticipated results demonstrated that although recombi

219 To account for these unanticipated results, a new mechanism that involves act

220 Any overlap did not predict unanticipated return to surgery (9.8% any overlap vs 10.

221 e in reoperation, readmission, ER visits, or unanticipated return to surgery.

222 These methodological advances led to unanticipated revelations: 1) Many RNA populations are i

223 These results reveal unanticipated risks of 6PPD antioxidants to an aquatic s

224 These findings establish an unanticipated role for ATM in the signaling of DNA SSBs

225 this issue of JEM, Swanson et al. report an unanticipated role for cGAMP in priming and activation o

226 The results from this study suggest an unanticipated role for chromatin modification in TSC and

227 Thus, we have uncovered an unanticipated role for hCDC14A in cell migration and adh

228 s of the PAO/phyllobilin pathway, we show an unanticipated role for one of the pathway intermediates,

229 Our results therefore highlight an unanticipated role for p53 family proteins in a regulato

230 This is an unanticipated role for Sst interneurons, which have been

231 ween caloric load and reward and describe an unanticipated role for sweet taste in regulating carbohy

232 This study identifies an unanticipated role for the X-linked inhibitor of apoptos

233 ly-competent nucleation seed, but we find an unanticipated role for them in enhancing the persistence

234 finding is important because it uncovers an unanticipated role for TRPV4 in itch, thereby identifyin

235 Interestingly, we found that Mot1 has an unanticipated role in establishing or maintaining the oc

236 ate of mGlu5 within BNST plays a central and unanticipated role in excessive alcohol consumption.

237 g state within BNST that plays a central and unanticipated role in excessive alcohol consumption.SIGN

238 Our results reveal an unanticipated role of Cav-1 in regulating lipolysis in n

239 Our findings reveal an unanticipated role of Cln1 in regulating lysosomal targe

240 This unanticipated role of Ctp1 might help explain how the pr

241 cute O(2) regulation of breathing, reveal an unanticipated role of HIF2alpha, and link acute and chro

242 These results reveal an unanticipated role of IN for polyprotein proteolytic pro

243 ational modeling, we identified a previously unanticipated role of leukocytes for microvascular clot

244 These observations identify an unanticipated role of MAP4K4 in transformation and show

245 This study identifies an unanticipated role of Norrin in human brain cancer progr

246 Together, these data demonstrate an unanticipated role of parenchymal cells, as shown here f

247 This study also uncovers a previously unanticipated role of PLK1 as a potent activator of MAPK

248 nase and CAK activities of Mcs6, revealed an unanticipated role of the CAK branch in the transcriptio

249 Here, we shed light on a yet unanticipated role of Toll-like receptor 7 in the recogn

250 Here, we report an unanticipated role of Vps34 in the activation of p62 for

251 ve family of RNA binding proteins and reveal unanticipated roles for a lncRNA and PUMILIO proteins in

252 ies enabled by this mouse suggest previously unanticipated roles for ATP and P2X4 receptors in the ne

253 r data therefore reveal novel and previously unanticipated roles for CXCR2 in the orchestration of th

254 BK1 as a direct mTORC1 activator and suggest unanticipated roles for mTORC1 downstream of TBK1 in con

255 n scheme provides novel insight into several unanticipated roles for Shh, including priming the cochl

256 Here, we report unanticipated roles for the Escherichia coli Rep helicas

257 reens have added to our understanding of the unanticipated roles for VGCCs in nonexcitable cells.

258 Unanticipated roles of mechanical force sensing continue

259 and virus host cell interaction, and suggest unanticipated routes of subcellular cargo delivery.

260 patients with diabetic retinopathy, with no unanticipated safety events.

261 treatment-related study discontinuations, or unanticipated safety signals were observed through 12 mo

262 No unanticipated serious adverse events related to the impl

263 No unanticipated serious adverse events were observed.

264 There were no unanticipated serious adverse events.

265 An unanticipated severe neurologic disorder occurred after

266 interspecific interactions and produce rapid unanticipated shifts in the demographics of pest complex

267 approved for one or a few indications, their unanticipated side effects and off-label use have contri

268 effects of miRNAs create additional risks of unanticipated side effects.

269 owever, recent studies have demonstrated the unanticipated significance of sn-1 hydrolysis of arachid

270 s feedback regulation of Ctf19c assembly and unanticipated similarities in kinetochore organization b

271 roteins, such as PH3 and TTG2, and reveal an unanticipated similarity in the regulatory circuitry tha

272 We identify that these unanticipated solitons stem from displacive phase transi

273 We also report an unanticipated source of current fluctuations that reflec

274 ressors, can define geographical patterns of unanticipated species resilience to global environmental

275 nt kinase inhibitor p18(INK4c), revealing an unanticipated specificity between a GHV cyclin and a sin

276 provides insight into the role of previously unanticipated stereoelectronic effects that can be harne

277 do stimulate NBCe1-A can be explained by an unanticipated stimulatory effect of the CAs on an endoge

278 ny experimental structural data, revealed an unanticipated strategy for transmembrane protein acylati

279 ynamics, the targeting of which may offer an unanticipated strategy to halt glioma progression.

280 The COVID-19 pandemic has presented a major unanticipated stress on the workforce, organizational st

281 o the gamma-TuRC "seam." We also identify an unanticipated structural bridge that includes an actin-l

282 dilauroylphosphatidylcholine binding drives unanticipated structural fluctuations outside of the can

283 We discover the unanticipated structural requirement that TFP motors nee

284 Our results reveal a previously unanticipated structural role for natively unfolded GLFG

285 osomal, telomere fusions and evidence for an unanticipated sufficiency of DNA ligase 1 for these intr

286 rRNA) processing defects, thus indicating an unanticipated synthetic interaction between U2AF1, NPM1,

287 o discover agonist antibodies that engage an unanticipated target and regulate macrophage polarizatio

288 evelopmental disorders allows correlation to unanticipated target genes.

289 ne activity affected learning rate following unanticipated task changes, in a way that depended on pa

290 te to the pathogenesis of vEDS, highlighting unanticipated therapeutic opportunities.

291 When these crossovers are unanticipated, they appear to be the result of serendipi

292 excited state as one might expect, but from unanticipated through-space aromatic-dimer states.

293 sis reveals that cells have a remarkable and unanticipated tolerance for forced protein associations,

294 cases - before being recalled by the FDA for unanticipated toxicity in humans.

295 llectively, our results reveal an important, unanticipated transcriptional role of interphase condens

296 o previous studies, our findings indicate an unanticipated tumor-suppressive role for HIF2alpha in ne

297 bs used in human clinical trials resulted in unanticipated vascular complications, leading to heighte

298 th NDM-1, by crystallography, we observed an unanticipated VNRX-5133 binding mode involving cyclizati

299 However, ED may increase health risks in unanticipated ways, thus potentially reducing net benefi

300 educes vaccine-induced antigen reactivity in unanticipated ways.