ライフサイエンスコーパス: unappreciated

1 ve rapid, non-genomic actions that have been unappreciated.

2 rucial distinguishing attributes that remain unappreciated.

3 entially has a dynamic complexity heretofore unappreciated.

4 s identifies the previously undetectable and unappreciated 5hmC/5mCpGs as one of the major states for

5 These data reveal a previously unappreciated ability of TBT to increase risk for liver

6 cle, so each arenavirus protein likely plays unappreciated accessory roles during infection.

7 Our data support unappreciated and dominant oncogenic roles for MYF5 and

8 y of a particular phosphatase was previously unappreciated and exemplifies how a phospho-network is p

9 These data define previously unappreciated and important roles for GATs and astrocyte

10 Our findings reveal a previously unappreciated and isoform-specific role for NT-PGC-1alph

11 neutrophils, with the latter representing an unappreciated and understudied cell type that contribute

12 ome, and identify genes that were previously unappreciated as being critical for development.

13 Thus, we unveil a previously unappreciated aspect of control on chromatin and cell fa

14 These findings document previously unappreciated aspects of Blimp1's role in T cell biology

15 Here, we identify an unappreciated asset of platelets and show that adherent

16 Results highlight a previously unappreciated association between older adults' mesopic

17 ulatively, these data elucidate a previously unappreciated association of pre- and peri-implantation

18 These findings provide insight into an unappreciated attribute of the tumor landscape that cont

19 on in its function and identify a previously unappreciated auto-regulatory mechanism of mTORC1 activi

20 Together, our study elucidates a previously unappreciated axis connecting the Arg/N-end rule and the

21 ology and disease has uncovered a previously unappreciated breadth of mechanisms by which females and

22 The present study uncovered a previously unappreciated capability of CD8(+) cytotoxic T cells to

23 d RNA (ssRNA) leviviruses, have a previously unappreciated capacity for evolving novel inhibitors of

24 r, P-HIPSTer enables discovery of previously unappreciated cellular circuits that act on human-infect

25 As a result, we report an unappreciated cellular complexity of the continuously-gr

26 size of the nucleation seed as a previously unappreciated characteristic of prion variants that is k

27 in input populations can identify previously unappreciated circuit elements that critically support b

28 is study demonstrates microproteins to be an unappreciated class of genes that are critical for inter

29 The differences reported herein may reflect unappreciated clinical differences in patients infected

30 ell (HSC) clones and to uncover a previously unappreciated clonal bottleneck in the response of HSCs

31 continues to uncover critical and previously unappreciated clues in understanding the pathophysiology

32 This work reveals a previously unappreciated complexity associated with LRH-1 agonist d

33 Our findings revealed previously unappreciated complexity in the signaling network downst

34 in meiotic prophase, revealing a heretofore unappreciated complexity of the epigenetic landscape at

35 This study reveals an unappreciated complexity of the larval zebrafish mechano

36 exosome pathway dysfunction is a previously unappreciated component of the brain pathologies that oc

37 The 2La inversion is a major and previously unappreciated component of the natural malaria transmiss

38 Herein we introduce a previously unappreciated concept that enables nearly complete para

39 do not induce IPEX manifestations, may have unappreciated consequences in other diseases.

40 These results demonstrate previously unappreciated consequences of LRRK2-dependent mitochondr

41 These data reveal a previously unappreciated contribution of dual TCR cells to the immu

42 Our findings reveal a previously unappreciated contribution of FN-alpha5beta1 integrin to

43 Here we describe a previously unappreciated contribution of microchannel deformation t

44 cally relevant substrates and the previously unappreciated contribution of protein cofactors to PBP a

45 These results uncover previously unappreciated contributions of chronic microglial toxici

46 Our results reveal previously unappreciated cooperative roles for T(reg) cell-derived

47 We identify previously unappreciated correlates of spindle activity, including

48 We also observed a previously unappreciated CpG flanking sequence bias in major and mi

49 Collectively, our data reveal a previously unappreciated critical cell-autonomous role of TNF on mo

50 the homeobox protein HOXC10, largely due to unappreciated defects in PRC2, which confers sensitivity

51 Additionally, we demonstrate evidence for an unappreciated degree of cellular and secretory activity

52 ods used in these studies reveals a hitherto unappreciated difference between those studies reporting

53 that different POLE mutants have previously unappreciated differences in replication fidelity and mu

54 an be serotonylated, suggesting a previously unappreciated direct mechanism of potential crosstalk be

55 es have led to new discoveries of previously unappreciated disease subtypes characterized by distinct

56 ncing of nkx2.5(+) cells revealed previously unappreciated distinct differentiation states and progen

57 neration sequencing has uncovered previously unappreciated diverse LGG entities, unraveling genetic s

58 Our results reveal previously unappreciated diversity and dynamics in the inactive con

59 Our data demonstrate previously unappreciated diversity of function within the Scrib mod

60 Ha and colleagues describe a previously unappreciated diversity of microbes in the mesenteric ad

61 Our resource reveals the previously unappreciated diversity of protein phosphorylation in hu

62 the entire PCu(A)C family reveals previously unappreciated diversity, including sequences that contai

63 rbours in its C-terminal region a previously unappreciated DNA-binding domain that exhibits specific

64 c suppression analysis uncovers a previously unappreciated, DNA repair-independent function of BRCA1

65 Further, we identified a previously unappreciated downstream kinase cascade regulated by Cdk

66 ranscription factor footprints, revealing an unappreciated driver of cis-regulatory evolution.

67 ata indicating that efferocytosis is a major unappreciated driver of lesion expansion but also a reve

68 Our screens identified both known and unappreciated drivers of BRAFi resistance, including mul

69 D-L1/PD-1 signaling pathway has a previously unappreciated dual role in the induction and regulation

70 U2AF1b, but their functional differences are unappreciated due to their homology.

71 Our studies establish the previously unappreciated DUX-miR-344-Zmym2/Lsd1 axis that controls

72 We propose a heretofore unappreciated effect of chronic HFD on beta-cells, where

73 get gene expression, suggesting a previously unappreciated effect of DAC on transcriptional regulatio

74 the nature and magnitude of these previously unappreciated effects, using available estimates of pale

75 This study identifies a previously unappreciated enzymatic function of rapsyn and a role of

76 s are compromised, and suggests a previously unappreciated epigenetic conflict on evolving Y chromoso

77 lial cell proliferation may be indicative of unappreciated evolutionary functional redundancy to faci

78 the alligator lineage is capable of hitherto unappreciated extreme locomotor performance despite a la

79 g research is revealing multiple, previously unappreciated, facets of immunity in the central nervous

80 Thus, phosphate steering is an unappreciated FEN1 function that enforces 5'-flap specif

81 oth established markers and genes previously unappreciated for their presence in ECs.

82 sequence of YAP1 activation via a previously unappreciated FSTL5-Hippo pathway regulatory axis.

83 nt pK(a)s and argue that CA has a previously unappreciated function as a major source of protons in b

84 These results uncovered a previously unappreciated function for Aire and provide new insights

85 Our data thus suggest a previously unappreciated function for monocytes in IL-7 biology and

86 Our results thus reveal a previously unappreciated function of IRAP-dependent endosomal TCR s

87 Our study reveals an unappreciated function of LNK in melanoma and highlights

88 ting that p-T153/Y155 regulates a previously unappreciated function of TDP-43 in the processing of nu

89 Our findings reveal the previously unappreciated function of the PR and the underlying mech

90 The chaperone thus serves a previously unappreciated function, helping multi-domain proteins ov

91 Our data reveal unappreciated functional diversification of SRPK to regu

92 Here, we reveal previously unappreciated functional heterogeneity between the Vdelt

93 We detected previously unappreciated functional motifs including adaptor protei

94 rone- and progesterone-activated MR may have unappreciated functions in reproductive physiology.

95 semaphorin 3F, has important and previously unappreciated functions in the development and adult mai

96 the discovery of unexpected, and previously unappreciated, functions of their intensively studied en

97 ux from host cellular stores is a previously unappreciated GAS virulence mechanism that promotes SSA

98 homeostasis, and thereby unveil a previously unappreciated glucose-lowering effect of small intestina

99 w how these statistics can reveal previously unappreciated grouping phenomena, and provide a framewor

100 al coincidence, but also revealed previously unappreciated grouping principles.

101 evel have led to the discovery of previously unappreciated heterogeneity in many organs and tissues.

102 Here, we reveal a previously unappreciated heterogeneity in the biosynthetic capaciti

103 These data reveal unappreciated heterogeneity, complexity, and unconventio

104 Wnt-independent one and unveil a previously unappreciated HIFalpha-Sox9 pathway in regulating OPC di

105 own but are likely due in part to previously unappreciated host, microbiota, and environmental factor

106 Thus, our work suggests that C. fetus is an unappreciated human intestinal pathobiont likely spread

107 a demonstrate the generation of a previously unappreciated IL-10 producing ILC2 effector cell populat

108 are progenitor subsets and revealed hitherto unappreciated ILC precursor heterogeneity.

109 these results bring to light the previously unappreciated impact of side-chain conformation on charg

110 The data establish an unappreciated important role for BMPs and activins in ce

111 Beyond previously unappreciated individual- and cell-type-specific interfe

112 Moreover, targeting this previously unappreciated innate pathway might provide an important

113 uscle microtissues that reveals a previously unappreciated interaction between active cell mechanics

114 We demonstrate previously unappreciated interpatient variation in HIV protease pro

115 e from the neocortex and reveal a previously unappreciated interplay between brain state physiology a

116 r absolute activation state, highlighting an unappreciated interplay between these modifications.

117 thermore, absence of ITK led to a previously unappreciated intrinsic defect in degranulation.

118 Together, this study identifies a previously unappreciated intrinsic mechanism of FRCs shared between

119 inopathy (OIR) model, including a previously unappreciated 'knotted' morphology to pathological vascu

120 Our findings reveal an unappreciated layer of hepatocyte-intrinsic immunity to

121 ptotic Bcl-2 proteins represent a previously unappreciated level of apoptosis regulation.

122 Our results identify a previously unappreciated level of diversity in the outcomes of CAR

123 These findings reveal a previously unappreciated level of molecular complexity in the physi

124 This analysis revealed previously unappreciated levels of cellular heterogeneity within th

125 ronal subtypes, we also uncovered previously unappreciated limitations by showing that newborn neuron

126 cell fate and establish a direct, previously unappreciated link between alternative polyadenylation a

127 TF6 serves an important role as a previously unappreciated link between the ER stress and oxidative s

128 microRNA, miR-204, and uncover a previously unappreciated link between TXNIP and incretin action.

129 ta demonstrate that CHMI leads to previously unappreciated long-lasting alterations in the human inna

130 These data reveal a previously unappreciated means to stabilize a disulfide bond and hi

131 Together, our data reveal a previously unappreciated mechanism by which GOF mutant p53 hijacks

132 ion of DOCK5 by GIT2 represents a previously unappreciated mechanism for coordination of Rho and Rac

133 We highlight an unappreciated mechanism for growth coordination, where o

134 la-nigra interactions represent a previously unappreciated mechanism for influencing emotional behavi

135 Overall, our results reveal a previously unappreciated mechanism for inherited MPN risk through t

136 gether, our results highlight amitosis as an unappreciated mechanism for restoring stem cell homeosta

137 These data demonstrate a previously unappreciated mechanism for the recruitment and expansio

138 These findings reveal an unappreciated mechanism for the salutary effects of resi

139 Taken together, we elucidated an unappreciated mechanism in which PML, an IFNalpha-induci

140 Our results suggest a previously unappreciated mechanism of action of celastrol in the re

141 These findings uncover a previously unappreciated mechanism of metazoan gene repression, aki

142 Thus nuclear rupture may be an unappreciated mechanism of mutagenesis.

143 that this pattern results from a previously unappreciated mechanism that may apply to many species w

144 Together, our results identify a previously unappreciated mechanism that modulates calcium-mediated

145 McTNs represent a previously unappreciated mechanism through which cells engage nanop

146 , such as CCN1, is therefore a potential yet unappreciated mechanism to impair metastasis.

147 Our results reveal a previously unappreciated mechanism underlying human hemoglobin swit

148 -1's interaction with ChREBP as a previously unappreciated mechanism whereby glucose signals are both

149 This reveals a previously unappreciated mechanism within the Wnt pathway, where ge

150 Our data reveal previously unappreciated mechanistic complexity in TQC substrate de

151 immune pathogenesis, and point to previously unappreciated metabolic control of plasticity in helper

152 iR-17 family, but also suggested a number of unappreciated miRNA functions.

153 that E6-expressing cells exhibit previously unappreciated mitotic defects that likely contribute to

154 promoting mutations and reveals a previously unappreciated oncogenic EGFR mutation, A702V, demonstrat

155 ade in these patients, revealed a previously unappreciated origin of these malignant cells, identifie

156 These findings reveal a previously unappreciated outcome for neutrophil-macrophage imbalanc

157 es to established paradigms, indicating that unappreciated p53 functions contribute to cancer prevent

158 These findings offer a previously unappreciated parallel in the serial choice setting of o

159 issue-resident T cells may play a previously unappreciated pathogenic role in acute GVHD.

160 Thus, the IGF system represents a previously unappreciated pathway by which type 3 immunity is modula

161 We elucidate a previously unappreciated pathway for endogenous tissue repair by a

162 Our results reveal a previously unappreciated pathway in which a microbiota- and IL-1bet

163 in pre-B ALL cells and reveals a previously unappreciated pathway in which E2A-PBX1 acts in concert

164 Together, this study reveals a previously unappreciated pathway through which H3K9me3 directly rei

165 ental observations and identifies previously unappreciated physical contributions to retroviral integ

166 These findings reveal a previously unappreciated physiologic specificity of ATP and a facet

167 hese observations demonstrate the previously unappreciated postnatal role of PDGFA/PDGFRalpha in cont

168 c noncoding RNAs, demonstrating a previously unappreciated prevalence and potential for function.

169 cells appeared to be driven by a previously unappreciated problem of soluble Env and virions from th

170 esses virus-cell attachment and a previously unappreciated process of HIV-1-mediated down-regulation

171 we found that the developing cerebellum has unappreciated progenitor plasticity, since it undergoes

172 ells of the antral stomach have a previously unappreciated propensity for conversion into functional

173 This study describes a previously unappreciated protective role for IL-17RA signaling in r

174 proinflammatory gene modules, and previously unappreciated proximal tubule-specific bidirectional lnc

175 Our findings identify a previously unappreciated reciprocal interaction between GABA and th

176 The study thus revealed an unappreciated regenerative potential of the young DG and

177 spatial LCM enabled us to uncover previously unappreciated regionalization of gene expression in the

178 We further identify GRB10 as a previously unappreciated regulator of terminal erythropoiesis.

179 lts identify Notch signaling as a previously unappreciated regulator of Th1 and Th2 immunity and an i

180 This study not only reveals a hitherto unappreciated regulatory mechanism of ferroptosis but al

181 Thus, our analyses identify a previously unappreciated regulatory mechanism of MYC expression.

182 Our results illuminate previously unappreciated regulatory roles of DNA cleavage activity

183 chanism is likely a prevalent but previously unappreciated regulatory switch used by the widely distr

184 Bioinformatics reveals an unappreciated relationship between Src kinases, paxillin

185 solution microscopy, we visualize previously unappreciated reorganization of pre-existing actin filam

186 n addition to SAMHD1, overcomes a previously unappreciated restriction for lentiviruses at the level

187 )/carnitine malnutrition hypothesis, that an unappreciated risk factor for ASD is diminished capacity

188 Hence, dAKAP1 plays a previously unappreciated role as a molecular interface between seco

189 We have identified an unappreciated role for a phosphosite, Y192, within the L

190 Combined, these results uncover a previously unappreciated role for acute posttranslational palmitoyl

191 ene expression, and we identify a previously unappreciated role for AhR signaling in CoV pathogenesis

192 These data reveal a hitherto unappreciated role for an IL-10-STAT3-Blimp-1 circuit as

193 These findings reveal a previously unappreciated role for B cells in regulating the balance

194 ctively, these findings highlight a hitherto unappreciated role for BAs in WD-induced impairment of t

195 e tumorigenesis, thus revealing a previously unappreciated role for C-Raf in potentiating B-Raf funct

196 We also report a previously unappreciated role for CD8(+) T-cells in mediating rVSV-

197 Collectively, these data suggest a hitherto unappreciated role for CXCR2 in mediating cellular senes

198 Our data highlight a previously unappreciated role for dendritic cells in controlling gu

199 Our findings demonstrate a previously unappreciated role for direct DA input to the master cir

200 These findings reveal a previously unappreciated role for dysfunctional tissue repair in lo

201 vo requires E2F-2, and we also identified an unappreciated role for E2F-2 in erythroblast enucleation

202 These findings reveal an unappreciated role for exosomes in the pathogenesis of d

203 r cells in vitro, demonstrating a previously unappreciated role for EZH2 in the development of MDSCs.

204 Taken together, our results suggest an unappreciated role for fatty acids in the regulation of

205 We have recently reported a previously unappreciated role for HSF1 in the regulation of energy

206 of ORAI1 inactivation, and reveal a hitherto unappreciated role for inactivation in shaping cellular

207 Together, these findings reveal a novel, unappreciated role for iron in modulating macrophage beh

208 We uncover a previously unappreciated role for Mannose phosphate isomerase (MPI)

209 Our results suggest a previously unappreciated role for mechanosensitive ion channels in

210 Collectively, our data reveal a previously unappreciated role for miR-223 in regulating the innate

211 Altogether, these results demonstrate an unappreciated role for MRs in controlling CA2 pyramidal

212 rbance spectroscopy] and report a previously unappreciated role for MTF1 and copper (Cu) in cell diff

213 We uncovered a previously unappreciated role for mTRF1 in the suppression of telom

214 ogether, these data demonstrate a previously unappreciated role for Nlrp12 in exacerbating the pathog

215 These studies define a previously unappreciated role for p38delta in breast cancer develop

216 bstrates for ZDHHC14 and reveal a previously unappreciated role for palmitoylation in control of neur

217 ken together, our work supports a previously unappreciated role for retrograde mitochondrial transpor

218 Our study reveals a previously unappreciated role for SIGN-R1(+) macrophages in regulat

219 Our work reveals an unappreciated role for the Astrin/SKAP complex as an ast

220 Our data delineate a major, previously unappreciated role for the cerebellum in controlling the

221 ouse models of EEC deficiency to identify an unappreciated role for the EEC hormone peptide YY in reg

222 d together these studies reveal a previously unappreciated role for the importance of membrane sealin

223 hin the kinase catalytic cleft, including an unappreciated role for the kinase beta3-alphaC loop regi

224 bryonic chromosomes and uncover a previously unappreciated role for the lamina in systemic chromosome

225 Collectively, these data reveal an unappreciated role for TRIM14 in resolving type I IFN re

226 ectively, these findings identify a hitherto unappreciated role for tumor cell-derived IL1beta in orc

227 suggest that CaMKIIalpha plays a previously unappreciated role in ASD-related synaptic and behaviora

228 im15/Gwl regulation of PP2A plays a hitherto unappreciated role in cell size homeostasis during metab

229 ur results demonstrate that HSP90beta has an unappreciated role in controlling hepatic progenitor cel

230 possibility that RBCs may play a previously unappreciated role in heart disease.

231 Thus, BAFF plays a previously unappreciated role in lupus nephritis by inducing renal

232 tic thermal convection may play a previously unappreciated role in mediating surface-catalyzed synthe

233 caused disturbance plays a major and largely unappreciated role in pantropical ecosystem dynamics and

234 een monomeric vs dimeric states has a hereto unappreciated role in semaphorin biology, providing a me

235 y suggests that SIRPalpha plays a previously unappreciated role in sHLH/cytokine storm syndrome patho

236 ty of CAFs may play a crucial and previously unappreciated role in the formation of tumor-associated

237 tention in the bone marrow play a previously unappreciated role in viral control and contrast the pot

238 n complexes and that Arf6 plays a previously unappreciated role in viral replication.

239 together, our results establish a previously unappreciated role of BAP1 in modulating the cellular ad

240 Our results reveal a previously unappreciated role of BCL6 in modulating neutrophil apop

241 Our study illuminates a previously unappreciated role of BRD4S in organizing chromatin and

242 in vitro and in vivo, we reveal a previously unappreciated role of cAMP response element binding prot

243 pendent RTT phenotypes, reveals a previously unappreciated role of CREB signaling in RTT pathogenesis

244 Our results reveal a previously unappreciated role of dendritic cells within the develop

245 ze public data sets and uncover a previously unappreciated role of epigenome deregulation in the gene

246 d mice, the latter highlighting a heretofore unappreciated role of GABAergic MnPO neurons in thirst r

247 er, these observations point to a previously unappreciated role of GS protein-coupled A2aR in regulat

248 Thus, understanding of the previously unappreciated role of H2-O (HLA-DO) in immunity to infec

249 findings reveal an important and previously unappreciated role of IRBP in protecting the photorecept

250 Our results reveal a previously unappreciated role of LRP4 in AD development.

251 This study reveals a previously unappreciated role of membrane pore polarity in determin

252 ether, these findings establish a previously unappreciated role of NELF in constraining transcription

253 Overall, our work describes a previously unappreciated role of nuclear PTEN, which by interacting

254 gether, these findings unveiled a previously unappreciated role of p62 in the regulation of BCSCs, as

255 ancer cell survival and uncover a previously unappreciated role of SLC7A11 to promote cancer cell dep

256 Taken together, these data revealed an unappreciated role of SOX7 in regulation of cellular apo

257 Here we deciphered a previously unappreciated role of Steroid receptor coactivator 1 (SR

258 Conceptually, our study indicates an unappreciated role of the NLRP3 inflammasome in promotin

259 The findings demonstrate a previously unappreciated role of tPA in Abeta-related neurovascular

260 ogether, these findings uncover the hitherto unappreciated role of tumor cell-expressed ANGPT2 as an

261 d mass carbon export events and highlight an unappreciated role of viruses in regulating diatom life

262 This work reveals previously unappreciated roles for ATF6alpha and ATF6beta in regula

263 ltogether, these results identify previously unappreciated roles for DNA MMR as a central modulator o

264 and, as a result, have uncovered previously unappreciated roles for microglial immunometabolism in s

265 iastolic heart disease and define previously unappreciated roles for Micu2 in regulating angiotensin

266 te the identification of TFs with previously unappreciated roles in CD8(+) T cell differentiation.

267 miR-200b endothelial target with previously unappreciated roles in the tumor microenvironment in lun

268 ymatic functions could be critical, as these unappreciated roles may hold clues to the ineffectivenes

269 onal heterochromatin and point to previously unappreciated roles of NDR positioning within heterochro

270 These previously unappreciated roles of PIK3CA mutation show that PI3K si

271 Thus, cilia provide a previously unappreciated route for the secretion of amidated signal

272 this large-scale analysis reveals previously unappreciated sarcoma-type-specific changes in copy numb

273 results indicate that including a previously unappreciated score that quantifies tissue-specific nucl

274 vivo recordings further reveal a previously unappreciated selective modulation of SPNs based on thei

275 een T cells for active TGFbeta represents an unappreciated selective pressure that promotes the accum

276 r homology clusters of FZDs, we discover yet unappreciated selectivities of WNTs to their receptors a

277 KT actions examined, indicating a previously unappreciated selectivity in mTORC2-AKT signaling.

278 based on selectively disrupting a previously unappreciated signaling cascade.

279 LORe has unappreciated significance as a nested component of post

280 This work reveals that ERVs are a previously unappreciated source of AML enhancers that may be exploi

281 Our work reveals previously unappreciated specificity within the cholinergic system

282 us to identify and characterize a previously unappreciated spectrum of transcriptional states in huma

283 Together, these results reveal an unappreciated step in the tubulin cycle.

284 ancer cells that had until recently remained unappreciated, strategies targeting cancer metabolic dep

285 n and reveal the existence of two previously unappreciated subdivisions in the female VMHvl that are

286 First, we identify a previously unappreciated subpopulation that secretes high levels of

287 and in vivo experiments to reveal previously unappreciated subspecies dynamics during VRE domination

288 pathway in HCMV infection reveal previously unappreciated targets for the development of vaccines an

289 esults suggest that OTR antagonists may have unappreciated therapeutic potential for stress-induced p

290 the smooth muscle of human bronchi suggests unappreciated therapeutic targets in the management of o

291 way may be a relevant approach of heretofore unappreciated therapeutic utility.

292 zation modulators, including many previously unappreciated transcription factors, sensory receptors,

293 Further analysis uncovers previously unappreciated transcriptional prepatterning in cortical

294 This approach identified several previously unappreciated transcriptional regulators that are highly

295 These findings uncover previously unappreciated transmission dynamics and support a ration

296 that choroidal macrophages play a previously unappreciated trophic role in maintaining choroidal vasc

297 Our results reveal a previously unappreciated tumor suppressor function of FTO in ovaria

298 Our findings reveal a previously unappreciated, tumor-specific metabolic pathway hijacked

299 We conclude that this previously unappreciated tyrosine residue is key to anchoring the i

300 mphatic network has shed light on previously unappreciated ways that an immune response can be elicit