ライフサイエンスコーパス: uncoordinated

1 y die as embryos or larvae, and are severely uncoordinated.

2 NS feedback, contraction of body segments is uncoordinated.

3 ilia in Drosophila, leaving the fly deaf and uncoordinated.

4 d States have tended to be opportunistic and uncoordinated.

5 ully 4-connected or 3-connected with one arm uncoordinated.

6 ns, where the mitochondrial movement becomes uncoordinated.

7 unction mutants are small, slow growing, and uncoordinated.

8 hat the novel Src homology (SH) 3/SH2 ligand-Uncoordinated 119 (Unc119) associates with CD3 and CD4,

9 >GTC; V22G) of the signaling adaptor protein Uncoordinated 119 (Unc119) in an ICL patient.

10 The transport depends on the adaptor protein Uncoordinated 119 (Unc119), on the GTPase rat brain 11 (

11 e strongly affected by the signaling protein uncoordinated 119 (Unc119).

12 A mammalian uncoordinated 119 protein (UNC119), also known as Retina

13 show a specific role for Rab34 and mammalian uncoordinated 13-2 (Munc13-2) in phagolysosome biogenesi

14 f four of the five proteins in the mammalian uncoordinated-13 (Munc13) family have been identified as

15 tor (SNARE) and Secretory 1 (Sec1)/mammalian uncoordinated-18 (Munc18)-like (SM) proteins, but it is

16 , a mechanism likely shared by the mammalian uncoordinated-18-1 protein (Munc18-1).

17 usly expressed Sec1/Munc18 protein mammalian uncoordinated-18c (Munc18c) regulates membrane fusion by

18 igration, where the presence of the receptor Uncoordinated-5 (UNC-5) on target cells results in repul

19 id inappropriate partners by using the FLRT2-uncoordinated-5 (UNC5) receptor-ligand system.

20 The repulsion-mediating netrin-1 uncoordinated-5 (UNC5) receptors are expressed by neuron

21 Neogenin, uncoordinated-5 (UNC5)A, and UNC5B were expressed at low

22 g netrin-1, deleted in colorectal cancer, or uncoordinated-5 homolog B (UNC5B) decreases YAP protein

23 receptors, deleted in colorectal cancer and uncoordinated-5 homolog, up-regulates YAP expression, es

24 Here, we reveal crystal structures of Uncoordinated-5 receptor D (Unc5D) in complex with morph

25 f rapamycin signaling and phosphorylation of uncoordinated 51-like kinase (ULK) 1 in mtDNA-mutator mi

26 t promoted vascular permeability through the uncoordinated 5B (UNC5B) receptor.

27 UNCoordinated-6 (UNC-6) was the first member of the netr

28 f-function mutations of the RYR gene unc-68 (uncoordinated 68) essentially abolished large-amplitude

29 Finally, we identify uncoordinated-76 (UNC-76/FEZ1) as a downstream effector

30 Uncoordinated 93 homolog B1 (UNC93B1) is a multiple memb

31 ough viable, d-plp mutant flies are severely uncoordinated, a phenotype usually associated with defec

32 nct from the resolution activity) are due to uncoordinated actions of the catalytic domains.

33 rons and resulted in more neurons exhibiting uncoordinated activity patterns at later time points.

34 nteric neurons usually displayed ongoing but uncoordinated activity.

35 lied neuromodulators or toxins can result in uncoordinated activity.

36 e previously uncounted costs associated with uncoordinated adaptation actions and demonstrate that a

37 of the dominant act-2 mutations resulted in uncoordinated adult movement.

38 g off from the intact cluster can expose the uncoordinated Ag atom as the catalytically active site f

39 54% of the 1-octene retention factor of the uncoordinated [Ag(+)][NTf(2)(-)].

40 ion of a thiourea-nitronate complex with the uncoordinated aldehyde.

41 the smallest change compared to that of the uncoordinated alkyne.

42 Animals mutant in this gene are severely uncoordinated and also exhibit defects in cell migration

43 aptojanin mutants in C. elegans are severely uncoordinated and are depleted of synaptic vesicles, pos

44 proceed through or to attempt to re-enter an uncoordinated and consequently fatal cell cycle.

45 Micelles encapsulate either a mixture of uncoordinated and coordinated (PPIX)Zn or all coordinate

46 Aggressive uncoordinated and coordinated approaches were highly sim

47 podermal P-cell nuclear migration results in uncoordinated and egg-laying-defective animals.

48 Too frequently, healthcare delivery is uncoordinated and has many providers who are not adequat

49 an attempt to re-enter the cell cycle in an uncoordinated and inappropriate manner.

50 ty for movement, although they are extremely uncoordinated and incapable of feeding.

51 subunit undergoes conformational transitions uncoordinated and independent of each other.

52 ble lev-8; acr-8-null mutant, which shows an uncoordinated and levamisole-resistant phenotype, reveal

53 cessive directional stepping, but it becomes uncoordinated and the stepping pattern shows a greater v

54 ion of cooperation assume that punishment is uncoordinated and unconditional.

55 and ventral nerve cord-resulting in sterile, uncoordinated animals-while others affect embryonic divi

56 xes developed in gastric muscles, leading to uncoordinated antral contractions, delayed gastric empty

57 t can dissociate to a copper(I) species with uncoordinated arylnitroso.

58 The three H atoms bridge the six uncoordinated Au atoms and are found to play a key role

59 e four H atoms are found to bridge the eight uncoordinated Au atoms at the interface.

60 consists of two Au(11) units bonded via six uncoordinated Au sites.

61 in a tridentate meridional fashion with one uncoordinated azo-arm from each of the ligands.

62 vised in the light of new data demonstrating uncoordinated behavior among kinetochore-associated micr

63 significant impairment of motility including uncoordinated bends, severely reduced beat frequency, an

64 herein is a "through-arene" activation of an uncoordinated benzylic C-H bond that is 6 bonds away fro

65 The waves were uncoordinated between recordings, except for rear and ba

66 dly induced several additional malformed and uncoordinated blood vessel structures that originated ou

67 o2 in proprioceptive neurons showed severely uncoordinated body movements and abnormal limb positions

68 een in adults, despite frequent instances of uncoordinated body movements.

69 dynamics and low triplet yields (~10%) when uncoordinated, but adopt distinct binding geometries on

70 formation gap that makes doctor shopping and uncoordinated care possible, states have created prescri

71 umbers of prescribers may signal dangerously uncoordinated care.

72 Loss-of-function mutants show irregular, uncoordinated cell divisions throughout embryogenesis, a

73 suppression of GGB or ROP GTPases is due to uncoordinated cell expansion, defects in cell wall integ

74 nse active matter, and argue that persistent uncoordinated cell motility coupled to the collective el

75 AKT-mTOR signaling, increased cell size, and uncoordinated cellular growth in E420K-variant cells.

76 le stage 2 bristling was replaced by slower, uncoordinated ceratal movements.

77 brospinal fluid (CSF) flow defects caused by uncoordinated cilia beating in ependymal cells.

78 Thus, bacteria elongate by the uncoordinated, circumferential movements of synthetic co

79 resulted in a transition from coordinated to uncoordinated collective movement along extracellular bo

80 21.3% more averted cases (n = 408) than did uncoordinated control at year 5.

81 s, facility-level infection control efforts (uncoordinated control measures), and a coordinated regio

82 atures CEST-active carboxamide groups and an uncoordinated crown ether moiety in close proximity to a

83 We find that uncoordinated, dam-by-dam hydropower expansion has resul

84 136,385 persons per km2 across clusters, and uncoordinated development, particularly in peripheral zo

85 y DOA4 is needed in S. cerevisiae to prevent uncoordinated DNA replication.

86 oteins is omitted from the dilution mixture, uncoordinated DNA synthesis occurs, and/or large Okazaki

87 ergone a formal [2+2] cycloaddition with the uncoordinated double bond of the 4,5-eta(2)-furan ligand

88 r a weak allele in vha-12 are viable but are uncoordinated due to decreased neurotransmission.

89 port large food items (either coordinated or uncoordinated during transportation), which can be rarel

90 iscrete behavioral deficits, including slow, uncoordinated eclosion and an insensitivity to ecdysis-t

91 In sharp contrast, only uncoordinated efforts aimed at developing small molecule

92 ubstrate, but how mitochondria contribute to uncoordinated electrical activity is poorly understood.

93 oduce a framework to quantify the effects of uncoordinated electrification on natural gas customers,

94 cytokine receptor family whose increased and uncoordinated expression may lead to myeloid leukemia by

95 ate the role of the mammalian Atg1 homologs, uncoordinated family member (unc)-51-like kinase 1 and 2

96 Caenorhabditis elegans CAPS ortholog UNC-31 (uncoordinated family member) and determined its role in

97 nt for Gbeta1, the pLLP cells migrated in an uncoordinated fashion and were unable to extend protrusi

98 ependymal cilia was disrupted, resulting in uncoordinated flow of CSF.

99 d on fee-for-service reimbursement, leads to uncoordinated, fragmented, and low-quality HF care.

100 (mammalian homolog of Caenorhabditis elegans uncoordinated gene 13) proteins play essential roles in

101 (mammalian homolog of Caenorhabditis elegans uncoordinated gene 18) proteins.

102 alian homolog of the Caenorhabditis elegans "uncoordinated" gene (unc-13), as a candidate gene for cr

103 est correlation of the distances between the uncoordinated Gla oxygen atoms is with the intercalcium

104 These results suggest a substantial cost of uncoordinated government responses to COVID-19 when peop

105 present a simple delay of growth but instead uncoordinated growth plate development.

106 . (2019) suggests a checkpoint that prevents uncoordinated growth.

107 DFT calculations to hydrogen bonding between uncoordinated H2O and a peroxo ligand.

108 an OOH* intermediate on the high density of uncoordinated hollow-site C atoms with respect to the Co

109 fects during crystallization that results in uncoordinated hydroxamate ligands or hydroxide-coordinat

110 This study reveals uncoordinated immune responses in SDp and provides insig

111 unc-3 mutants are uncoordinated in locomotion.

112 these phenotypes suggest that development is uncoordinated in Rgd2-R(-) mutant leaves, so that leaf c

113 The gene unc-76 (unc, uncoordinated) is necessary for normal axonal bundling a

114 g gait, and the cord of DCC KO mice exhibits uncoordinated left and right oscillations.

115 ng pattern, and the DCC KO network exhibited uncoordinated left-right activity.

116 max, limb movement is impaired, ranging from uncoordinated leg swimming to complete quadriplegia.

117 he enhanced porosity and availability of the uncoordinated Lewis acidic Bi sites, the defect-engineer

118 3a gene results in defective suckling and in uncoordinated limb and trunk movements, leading to early

119 trast, young infants display exaggerated and uncoordinated limb reflexes [2].

120 u pan-neuronal expression caused progressive uncoordinated locomotion (Unc), characteristic of nervou

121 ventral cord motoneuron precursors result in uncoordinated locomotion of unc-85 mutant larvae by the

122 a novel class of loss-of-function alleles of uncoordinated locomotion(unc)-108, which encodes the Cae

123 as follows: volatile anesthetic sensitivity, uncoordinated locomotion, and a constitutive alternative

124 ious phenotypes (short life span, sterility, uncoordinated locomotion, and morphological defects).

125 bends and a higher reversal rate and display uncoordinated locomotion.

126 ing of neuromuscular junctions, resulting in uncoordinated locomotion.

127 s, a disruption of any of these steps causes uncoordinated locomotory behavior (unc phenotype).

128 Heteroatom ligands with an uncoordinated lone pair (iminyl, NH(2), OH) undergo char

129 d amphibians-are in increasing peril through uncoordinated management and artificial barriers to huma

130 culate coordination's effects in relation to uncoordinated management and other reference scenarios.

131 to optimal coordinated management is optimal uncoordinated management, which can be identified at the

132 LacY, and the cavities open and close in an uncoordinated manner.

133 This does not agree with an uncoordinated mechanism where each subunit functions ind

134 met was 6000-fold more cytotoxic compared to uncoordinated metformin and significantly reduced tumor

135 In contrast, uncoordinated mitochondrial motility was observed in CRI

136 observed, which are related to stochastic or uncoordinated molecular processes.

137 Both uncoordinated motility of syncytia and adhesion to CD4(+

138 rprising given that flagella are actuated by uncoordinated motors.

139 ated tau accumulation, neurodegeneration and uncoordinated movement (Unc).

140 malities in body wall and sex muscles led to uncoordinated movement and egg-laying defects.

141 Two mutant alleles of the twk-18 gene confer uncoordinated movement and paralysis in C. elegans.

142 ranging from severe developmental delays and uncoordinated movement to subtle deficits in sensory and

143 -2 result in severe body morphology defects, uncoordinated movement, adult sterility, abnormal moltin

144 rations, malformation of the posterior body, uncoordinated movement, and defective egg laying.

145 ere previously recognized as having slightly uncoordinated movement, are highly resistant to ethanol

146 nt with premature aging, including kyphosis, uncoordinated movement, hypogonadism, infertility, sever

147 asting, hypogonadism, osteopenia, emphysema, uncoordinated movement, T cell dysregulation, and atroph

148 regated tau leading to neurodegeneration and uncoordinated movement.

149 and biochemical analyses indicated that the uncoordinated movements of these mutant filaments were c

150 These phenotypes include uncoordinated movements, variable embryonic lethality, a

151 nctive dysfunction of the hind legs, causing uncoordinated movements.

152 A class of uncoordinated mutants called "fainters" partially suppre

153 Pairs of uncoordinated N atoms on adjacent pyrazole dicarboxylate

154 effort could be nearly twice as efficient as uncoordinated, national-level conservation planning.

155 Initially uncoordinated neuronal activity became synchronized into

156 e Ru(IV) horizontal lineO oxo species to the uncoordinated nitrogen of the NPM ligand.

157 real-life simulation of the transition from uncoordinated, non-interacting individuals to a coordina

158 The uncoordinated, nonaromatic double bond of this ligand un

159 , returning to the pre-managed care model of uncoordinated open access to specialists is a poor solut

160 with all Ty1-related genes shut off, without uncoordinated or mosaic expression in any individual cel

161 nificantly reduced SNAP25 levels, leading to uncoordinated oscillations and poor glucose responsivene

162 xylate and ketone oxygen; (ii) attack of the uncoordinated oxygen of the bound O(2) on the ketone car

163 results in immediate paralysis, followed by uncoordinated peristalsis until the larva recovers suffi

164 hat syndicated debt markets are resilient to uncoordinated phase-out scenarios without regulatory lim

165 By using the uncoordinated phenotype as a read-out of TDP-43 overexpr

166 otor velocity in vitro but produces a severe uncoordinated phenotype in transgenic C. elegans, sugges

167 we screened for mutations that suppress the uncoordinated phenotype of UNC-17(G347R) mutants.

168 l overexpression of TDP-1 also results in an uncoordinated phenotype, while genetic deletion of the t

169 n downstream of exon 15, which results in an uncoordinated phenotype.

170 of cho-1 mutants, giving rise to a synthetic uncoordinated phenotype.

171 Pag-3 mutants also show a reverse kinker uncoordinated phenotype.

172 ronal expression of human TDP-43 exhibit an 'uncoordinated' phenotype and have abnormal motorneuron s

173 In the presence of oleic acid, the uncoordinated phosphine group of DBPP is converted into

174 on of vinculin in vivo and in vitro leads to uncoordinated polarity and deficient sprouting angiogene

175 The vast, uncoordinated proliferation of bioinformatics resources

176 h cooperation: cells mutate to phenotypes of uncoordinated proliferation.

177 Uncoordinated protein 45A (UNC-45A) is the only known AT

178 econd His ligand recruited from a previously uncoordinated protein side chain.

179 new Zn(4) L(4) tetrahedron 1 bearing twelve uncoordinated pyridyl units around its metal-ion vertice

180 During development, this seemingly uncoordinated reaction is a critical driver of cellular

181 pression experiments identified the receptor uncoordinated receptor-5 (UNC5A) as an antagonist of the

182 ing in other regions and the consequences of uncoordinated regional policies adopted in the presence

183 nonessential, and deleting this gene causes uncoordinated replication.

184 , and antibody responses are protective, but uncoordinated responses frequently fail to control disea

185 a complex adaptive system (CAS) in which the uncoordinated responses of nation states to changes in t

186 emerging from the hierarchical alignment of uncoordinated self-labeling actions.

187 In contrast to the uncoordinated sequential attachments of sister kinetocho

188 Mutations in the KLP64D gene cause uncoordinated sluggish movement and death, and reduce tr

189 partially via ligand release to re-form the uncoordinated species, in competition with binding of th

190 t prioritizes vaccination campaigns and uses uncoordinated staff incentives.

191 demonstrated that the "loss from anarchy" in uncoordinated state policies is increasing in the number

192 ned to optimize the effectiveness of random, uncoordinated stepping: (1) the formation of three-heade

193 uses different parts of the heart to receive uncoordinated stimulation.

194 suggest a developmental sequence where early uncoordinated structural growth amongst regions is follo

195 including cleft palate, poor feeding with an uncoordinated suck, hypotonia and decreased movement.

196 The eight uncoordinated surface gold atoms in the Au22(L(8))6 nano

197 l risk of developing malnutrition because of uncoordinated swallowing, gastroesophageal reflux, and c

198 trations resulting in reduced locomotion and uncoordinated swimming.

199 However, the uncoordinated switching of multiple motors interrupts an

200 lene groups, polyUiO-66-7a shows 7 +/- 3% of uncoordinated terephthalate linkers, while these are und

201 ehavioral experiments in which punishment is uncoordinated, the sum of costs to punishers and their t

202 d thiolates, e.g., metallothionein (MT), and uncoordinated thiolates, e.g., glutathione, react with b

203 contractions are weaker, less frequent, and uncoordinated throughout the sequence of ovulation event

204 s in a hexameric ring of a mutant p97 become uncoordinated, thus impacting its ability to process sub

205 Aged cells show a global increase of uncoordinated transcriptional heterogeneity biased towar

206 orylated in CD45 null NK cells, resulting in uncoordinated tyrosine-mediated signaling upon Ly-49D li

207 ated tau accumulation, neurodegeneration and uncoordinated (Unc) movement.

208 uncoordinated (unc) mutants of Drosophila, which lack tr

209 Nine uncoordinated (unc) mutations were used to block clumpin

210 of bar-1 from the 321-bp element rescued the Uncoordinated (Unc) phenotype of bar-1 mutants, but not

211 educed levels of CoQ result in a progressive uncoordinated (Unc) phenotype that is correlated with th

212 e to adulthood exhibit variably dumpy (Dpy), uncoordinated (Unc), and egg-laying defective (Egl) phen

213 In Caenorhabditis elegans, uncoordinated (unc)-55 encodes a nuclear hormone recepto

214 Coordinated Ca(2+) transients became uncoordinated using both these approaches, supporting th

215 Cerebellar damage results in uncoordinated, variable and dysmetric movements known as

216 interrupted cardiac morphogenesis following uncoordinated ventricular contraction.

217 ctility that appeared to be non-rhythmic and uncoordinated was observed in Ano1 KO jejunum.

218 lly reduced forward progressive velocity and uncoordinated waveform propagation along the flagellum.

219 field of pacing in Africa has evolved in an uncoordinated way across the continent with significant

220 ration within the GTPase domain that becomes uncoordinated when shifted to high temperature and that

221 thin the ICC-MY network in Ano1 KO mice were uncoordinated, while ICC-MY Ca(2+) transients in Ano1 WT

222 to address this issue have been isolated and uncoordinated, with little focus on sustainable and inte

223 ansduction, we discovered a line of deaf and uncoordinated zebrafish with defective hair-cell functio