ライフサイエンスコーパス: uncoupler

1 or prevented by previous depolarization with uncoupler.

2 omethoxy) phenylylhydrazone, a mitochondrial uncoupler.

3 hondria in the presence of 2,4-dinitrophenol uncoupler.

4 (+/-K(+)) is prevented by the presence of an uncoupler.

5 a2+ uptake was blocked with ruthenium red or uncoupler.

6 reatment with a liver-targeted mitochondrial uncoupler.

7 R Ca(2+) ATPase (SERCA) and acts on it as an uncoupler.

8 philic weak acid, can act as a mitochondrial uncoupler.

9 fect disappears when PMF is eliminated by an uncoupler.

10 inyl adenosine synthase, as well as being an uncoupler.

11 affinity modulator, and sarcolipin (SLN), an uncoupler.

12 active against Staphylococcus aureus, is an uncoupler.

13 orally active MEK1/2 inhibitor, acted as an uncoupler.

14 at pH 7.5 in the presence of a protonophoric uncoupler.

15 ugh KPF itself is not a direct mitochondrial uncoupler.

16 d are differentially affected by respiratory uncouplers.

17 ial respiratory inhibitors and mitochondrial uncouplers.

18 r than controls not exposed to mitochondrial uncouplers.

19 ffected by membrane potential or pH gradient uncouplers.

20 tarved cells or in cells treated with energy uncouplers.

21 is compromised by agents such as alcohols or uncouplers.

22 using pharmacological excitation-contraction uncouplers.

23 red class of imidazolopyrazine mitochondrial uncouplers.

24 ng our identified compounds as mitochondrial uncouplers.

25 blished 5-hydroxyoxadiazolopyridines as mild uncouplers.

26 o electron transfer chain inhibitors and ion uncouplers.

27 with ICG and perfused with electromechanical uncouplers.

28 ced interest in the clinical use of chemical uncouplers.

29 as determined by exposing M. tuberculosis to uncouplers.

30 Gap junction uncouplers (1-octanol, carbenoxolone, 18beta-glycyrrheti

31 pressed gap junction genes, and gap junction uncouplers, 18beta-glycyrrhetinic acid (18beta-GA) and o

32 europrotective efficacy of the mitochondrial uncoupler 2,4-dinitrophenol (DNP) in animals receiving s

33 The chemical uncoupler 2,4-dinitrophenol (DNP) was an effective and w

34 ly sixfold less potent than the prototypical uncoupler 2,4-dinitrophenol and phenocopies 2,4-dinitrop

35 r Alzheimer's disease, and the mitochondrial uncoupler 2,4-dinitrophenol for obesity.

36 A mitochondrial uncoupler, 2,4-dinitrophenol (at 1 mmol/L), blocked the

37 cium ionophore, A23187 and the mitochondrial uncoupler, 2,4-dinitrophenol (DNP) as damaging agents.

38 ng complex I or III, or by the mitochondrial uncoupler, 2,4-dinitrophenol (DNP), indicating ATP deple

39 o or in vivo, against the electron transport uncoupler 3-acetylpyridine (3AP).

40 The application of mitochondrial uncouplers (5 microM CCCP or 5 microM FCCP), eliminated

41 or 2,4-dinitrophenol (DNP, the mitochondrial uncoupler, 50 micromol/L) (15.7+/-2.7% versus 40.8+/-5.5

42 most with known antiinfective activity, for uncoupler activity.

43 have a reduced rate of consumption of ATP on uncoupler addition.

44 Uncouplers also inhibited a background K+ current and in

45 hlorophenyl hydrazone (CCCP; a mitochondrial uncoupler) alter [Ca2+]i and force transients.

46 ribution was inhibited by proton ionophores (uncouplers), alteration of alpha conformation by illumin

47 heart in the absence of an electromechanical uncoupler and (2) to elucidate the mechanism of verapami

48 Treatment of MDCK cells with a mitochondrial uncoupler and a Ca2+ ionophore led to ATP depletion, nec

49 tential titrated by stepwise additions of an uncoupler and expressed as a function of citrate synthas

50 omyocytes, were eliminated by a gap junction uncoupler and reappeared with its removal.

51 inhibition could be well predicted by using uncoupler and Up-rescue results.

52 enesulfonamide (FH535-M), was inactive as an uncoupler and Wnt inhibitor.

53 Uncouplers and blockers of membrane channels were used t

54 rom the primary site and thus act as symport uncouplers and inhibit transport.

55 t acute administration of DNP (mitochondrial uncoupler) and chronic administration of T(3) decrease e

56 Furthermore, U73122 (Gqalpha-PLC specific uncoupler) and GP2A (Gqalpha specific inhibitor) mirrore

57 nt inhibitor", FH535, functioned as a proton uncoupler, and in support of this finding, the N-methyla

58 Tyrphostin A9, a mitochondrial uncoupler, and several of its structural analogues decre

59 Using a combination of inhibitors, uncouplers, and antimycin A, and by following the kineti

60 d through sequential addition of substrates, uncouplers, and inhibitors in living cells.

61 sitivity of this oxidation to ionophores and uncouplers, and the absence of any delay in the onset of

62 l membrane with visible light results in the uncoupler- and inhibitor-sensitive synthesis of adenosin

63 Small molecule mitochondrial uncouplers are emerging as a new class of molecules for

64 Small-molecule mitochondrial uncouplers are gaining recognition as potential therapeu

65 Mitochondrial uncouplers are potent stimulants of the carotid body.

66 Mitochondrial uncouplers are small molecule protonophores that act to

67 Thus, common protonophoric uncouplers are synthetic activators of I(H) through AAC

68 potential of imidazolopyrazine mitochondrial uncouplers as drug candidates for the treatment of obesi

69 Treatment with chemical inhibitors or an uncoupler, as well as crosses to mutants known to affect

70 how that a recently identified mitochondrial uncoupler BAM15 is orally bioavailable, increases nutrie

71 D865 is a derivative of the furazanopyrazine uncoupler BAM15.

72 Application of the excitation-contraction uncoupler blebbistatin or the mechanosensitive channel b

73 ctivity in the dark induced by mitochondrial uncouplers, but PLC-independent activation of the channe

74 tabolic insults including treatment with the uncoupler carbonyl cyanide 3-chlorophenylhydrazone (CCCP

75 ere larger in the presence of cyanide or the uncoupler carbonyl cyanide 4-trifluoromethoxyphenylhydra

76 The mitochondrial oxidative phosphorylation uncoupler carbonyl cyanide m-chlorophenyl hydrazone (2 m

77 ly low concentrations (0.06 mg L(-1)) of the uncoupler carbonyl cyanide m-chlorophenyl hydrazone inhi

78 Although the uncoupler carbonyl cyanide m-chlorophenyl hydrazone inhi

79 the mitochondria membrane potential with the uncoupler carbonyl cyanide m-chlorophenyl hydrazone or t

80 The uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP

81 tapsi(m) conditions, hypersensitivity to the uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP

82 The electron transport uncoupler carbonyl cyanide m-chlorophenylhydrazone inhib

83 e pH gradient and strongly stimulated by the uncoupler carbonyl cyanide m-chlorophenylhydrazone when

84 phagy after treatment with the mitochondrial uncoupler carbonyl cyanide m-methylhydrazone, because of

85 itochondrial inhibitor NaCN and mitochondria uncoupler carbonyl cyanide p-(trifluoromethoxy) phenyl h

86 r Ca(2+) after addition of the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenyl hy

87 changes were sensitive to the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenyl-hy

88 -hydroxy-TEMPO (TEMPOL) or the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenylhyd

89 n kinases ERK1 and ERK2 by the mitochondrial uncoupler carbonyl cyanide p-(trifluoromethoxy)phenylhyd

90 disrupted by treating cells with the proton uncoupler carbonyl cyanide p-chlorophenylhydrazone.

91 However, like the mitochondrial uncoupler carbonyl cyanide p-trifluoromethoxyphenyl hydr

92 of the mitochondrial inhibitor NaCN, or the uncoupler carbonyl cyanide p-trifluoromethoxyphenylhydra

93 The uncoupler carbonyl cyanide-p-trifluoromethoxyphenylhydra

94 In the presence of the uncouplers carbonyl cyanide m-chlorophenylhydrazone or v

95 endent stress genes by the respiratory chain uncoupler, carbonyl cyanide m-chlorophenyl hydrazine (CC

96 by autophagy) stimulated by a mitochondrial uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCC

97 cal hypoxia model of mitophagy induced by an uncoupler, carbonyl cyanide m-chlorophenylhydrazone (CCC

98 class through the coronary arteries with the uncoupler, carbonyl cyanide p-trifluoromethoxyphenylhydr

99 ane potential was dissipated by the chemical uncoupler carbonylcyanide m-chlorophenyl hydrazone.

100 in the presence of Zn2+ was abrogated by the uncoupler carbonylcyanide m-chlorophenylhydrazone, sugge

101 It was also inhibited by the proton uncoupler carbonylcyanide m-chlorophenylhydrazone, sugge

102 kainic acid, and NMDA, and the mitochondrial uncoupler carbonylcyanide p-(trifluoromethoxy)phenyl hyd

103 The proton uncouplers carbonylcyanide-4-(trifluoromethoxy) phenylhy

104 The proton uncouplers carbonylcyanide-4-(trifluoromethoxy)phenylhyd

105 in purple membrane suspensions by the energy-uncoupler CCCP or by lysis of the cells.

106 nitazoxanide), its derivative RM4848 and the uncoupler CCCP were applied to a virus-releasing cell li

107 s TonB independent and was unaffected by the uncouplers CCCP (carbonyl cyanide m-chlorophenylhydrazon

108 yrphostins A9 and AG126 act as mitochondrial uncouplers, collapsing the mitochondrial membrane potent

109 ng respiration and ATP biosynthesis, and are uncouplers, collapsing the pH gradient and membrane pote

110 A lipophilic analog of the uncoupler compound 2,6-dinitrophenol, in which a C8-hydr

111 gation of a hydrophobic hydrocarbon chain to uncoupler compounds resulted in sustained or improved un

112 ieve this outcome by targeting mitochondrial uncoupler compounds selectively to adipose tissue, thus

113 , we explored the feasibility of conjugating uncoupler compounds with a lipophilic C8-hydrocarbon cha

114 of electron transport and DeltapH at various uncoupler concentrations or light intensities was obtain

115 tochondrial respiratory chain inhibitors and uncouplers decreased mitochondrial membrane potential le

116 hematical model that proposes a mechanism of uncoupler-dependent I(H) through AAC.

117 eficial effects of DNP suggest that chemical uncouplers deserve further investigation for the treatme

118 , application of glutamate together with the uncoupler did not prevent the changes in movement or sha

119 emonstrated that their relative potencies as uncouplers differed from their in vitro kinase-inhibitor

120 l CMRO2 in the presence of the mitochondrial uncoupler dinitrophenol (DNP) were compared using 16.4 T

121 However, serious adverse effects of the uncoupler dinitrophenol occurred when used to increase s

122 ine of these matched proteins induced by the uncoupler dinitrophenol.

123 d by a complex 1 inhibitor (rotenone) and an uncoupler (dinitrophenol) and by overexpression of mGPDH

124 d also by a mitochondrial membrane potential uncoupler, dinitrophenol, supporting a role for mitochon

125 Mitochondrial uncouplers dissipate this proton gradient and disrupt nu

126 BAM15, a chemical uncoupler, dissipates mitochondrial proton gradients wit

127 Chemical uncouplers do not induce obvious changes in Cx43-EGFP ju

128 single or repetitive pulses of substrate- or uncoupler-elicited energetic-redox transitions.

129 We have previously used measurements of uncoupler-enforced reverse activity to demonstrate that

130 the formation of a mixed complex between the uncoupler, ETH-129, and Ca(2+) that readily permeates th

131 We conclude that uncouplers excite the carotid body by inhibiting a backg

132 RN revealed that (1) RN is stimulated by the uncoupler FCCP and high levels of substrates, demonstrat

133 induction of mitophagy by the mitochondrial uncoupler FCCP is independent of the effect of mitochond

134 bstituting the trifluoromethoxy group in the uncoupler FCCP with a C8-hydrocarbon chain resulted in p

135 d by exceptionally low concentrations of the uncoupler FCCP without the need for exogenous pools of d

136 s were inhibited by hypoxia, cyanide and the uncoupler FCCP, but the greatest sensitivity was seen in

137 On the other hand, mitochondrial metabolic uncoupler FCCP, in the presence of oligomycin (to preven

138 cultured OLs treated with the mitochondrial uncoupler FCCP.

139 nd mouse HSCs were treated with the chemical uncouplers FCCP and Valinomycin.

140 ishes ATP production, a mitochondrial proton uncoupler, FCCP, and a glucose metabolic inhibitor, 2-DG

141 , however, is to discover safe mitochondrial uncouplers for practical use.

142 therapeutic potential of mild mitochondrial uncouplers for the prevention of diet-induced obesity.

143 ]oxadiazolo[3,4-b]pyridin-7-ol mitochondrial uncouplers for treatment of fatty liver disease and obes

144 hlorophenylhydrazone (CCCP), a mitochondrial uncoupler, found that more than half of the mitochondria

145 The therapeutic potential of mitochondrial uncouplers has been investigated for the treatment of me

146 her, our studies indicate that mitochondrial uncouplers have potential for the treatment of NASH.

147 Small molecule mitochondrial uncouplers have recently garnered great interest for the

148 m BAM15, a potent and mitochondria-selective uncoupler, have yielded promising preclinical candidates

149 The gap-junction uncoupler heptanol had no effect.

150 Treatment with the gap junction uncoupler heptanol significantly reduced the movement of

151 Ca(2+)-free dextran and by the gap junction uncoupler, heptanol, indicated that it was generated by

152 ntally by local perfusion of a mitochondrial uncoupler in a monolayer of cardiac myocytes.

153 characterized as a functional mitochondrial uncoupler in Drosophila.

154 Oleate does not substitute for the uncoupler in either regard.

155 tured hippocampal neurons to a mitochondrial uncoupler in glucose-free medium promotes the formation

156 ed of ATP by incubation with a mitochondrial uncoupler in glucose-free medium.

157 have led to suggestions that they may act as uncouplers in cells.

158 y Cx40-specific and nonspecific gap junction uncouplers in the lungs of wild-type mice and in lungs f

159 Both uncouplers increased the expression of mitochondrial gen

160 Uncouplers increased trap closure delay and significantl

161 espiration is also inhibited by nigericin or uncoupler, indicating that an acidic matrix pH antagoniz

162 in the presence of a mitochondrial membrane uncoupler, indicating that mitochondria are the main sit

163 inhibited by low concentrations of a proton uncoupler, indicating that PLUTO functions as a proton-s

164 In 60-hour-old biofilms, the extent of uncoupler-induced cell loss was strongly attenuated, ind

165 oxygen consumption studies using substrate, uncoupler, inhibitor, titration protocols; targeted meta

166 Substrate-uncoupler-inhibitor titration protocols were used: SUIT-

167 The capacity for MgATP-dependent, uncoupler-insensitive conjugate transport in vitro stric

168 olated from these cells for MgATP-dependent, uncoupler-insensitive DNP-GS transport.

169 more than 90% impaired for MgATP-dependent, uncoupler-insensitive DNP-GS transport.

170 yl)glutathione (DNP-GS), an MgATP-dependent, uncoupler-insensitive pathway and an electrically driven

171 ae is inferred to encode an MgATP-energized, uncoupler-insensitive vacuolar glutathione S-conjugate t

172 thways identified, only the MgATP-dependent, uncoupler-insensive pathway is subject to inhibition by

173 cytochrome bc (1):aa (3), as well as energy uncouplers, interfere with the bactericidal potency of i

174 that Endosidin9 (ES9), a novel mitochondrial uncoupler, is a potent inhibitor of clathrin-mediated en

175 enuated by the presence of the mitochondrial uncoupler M3778 but potentiated by the presence of cobal

176 Carbenoxolone, a Cx43 gap junction uncoupler, markedly prolonged the QRS duration, leading

177 We synthesized a new mitochondrial uncoupler MB1-47 and tested its effect on cancer cell me

178 acellular superoxide stress triggered by the uncoupler, menadione, Cygb had a prominent role in super

179 studies have suggested that a mitochondrial uncoupler might work in a similar manner.

180 I inhibitor), dinitrophenol (a mitochondrial uncoupler), muscle contraction, and sorbitol (producing

181 ng cancer metabolism using the mitochondrial uncoupler niclosamide ethanolamine leads to methylome re

182 In this study, we used a mitochondrial uncoupler, niclosamide ethanolamine (NEN), to activate m

183 /db mice were treated with the mitochondrial uncoupler, niclosamide ethanolamine (NEN), to determine

184 t blocked mitochondrial Ca(2+) accumulation (uncouplers, nocodazole) eliminated the observed inhibiti

185 in the presence of 0.1 mM dinitrophenol, an uncoupler of ATP synthesis.

186 occurring sVegfr-2 thus acts as a molecular uncoupler of blood and lymphatic vessels; modulation of

187 neurons pretreated with pertussis toxin, an uncoupler of G proteins and MOR.

188 nsmembrane receptors, or pertussis toxin, an uncoupler of G(i) from adenylate cyclase.

189 y increased Ptran (to 0.22) and heptanol, an uncoupler of gap junction channels, significantly decrea

190 The effects of pertussis toxin, an uncoupler of Gi protein from adenylate cyclase, and luzi

191 th application of 2,4-dinitrophenol (DNP, an uncoupler of mitochondrial ATP production) induced an in

192 Nitazoxanide is an uncoupler of mitochondrial oxidative phosphorylation (OX

193 he hypothesis that niclosamide is a stronger uncoupler of mitochondrial oxidative phosphorylation tha

194 arginine (ADMA), an endogenous inhibitor and uncoupler of nitric oxide synthase, has gained attention

195 ort complex II (thenoyltrifluoroacetone), an uncoupler of oxidative phosphorylation (carbonyl cyanide

196 morphology precludes UCP4 from acting as an uncoupler of oxidative phosphorylation but is consistent

197 f electron transport chain complex II, by an uncoupler of oxidative phosphorylation, by uncoupling pr

198 In this study, we found that the classic uncoupler of oxidative phosphorylation, carbonyl cyanide

199 l cyanide m-chlorophenylhydrazone (CCCP), an uncoupler of oxidative phosphorylation, completely preve

200 It is thought to be an uncoupler of oxidative phosphorylation.

201 Benzene, an effective uncoupler of oxygen consumption in purified naphthalene

202 us, azide does not appear to act as a simple uncoupler of proton transport and ATP hydrolysis.

203 We recently showed that sarcolipin (SLN), an uncoupler of the sarco(endo)plasmic reticulum Ca(2+) ATP

204 reversed by V-type ATPase inhibitors and by uncouplers of endosomal intralumenal pH, and was correla

205 phosphorylation events were not affected by uncouplers of oxidative respiration, inhibitors of elect

206 tment of cells with metabolic inhibitors and uncouplers of photosynthetic electron transport showed t

207 S) production through use of pharmacological uncouplers of the mitochondrial electron transport chain

208 bind mitochondria and function as endogenous uncouplers of UCP1-independent respiration.

209 pite a widely accepted role of arrestins as "uncouplers" of G protein-coupled receptor (GPCR) signali

210 on of respiratory chain (RC) components, and uncouplers on necrotic and apoptotic markers in 2D-cultu

211 re control, use of an excitation-contraction uncoupler, optimal vibratome settings and correct handli

212 rial Ca(2+) uptake by either a mitochondrial uncoupler or a Ca(2+) uniporter inhibitor.

213 Treatment of cultures with an uncoupler or blocking ATP synthesis with oligomycin also

214 ed with GSK inhibitors and were treated with uncoupler or cyanide or were made anoxic.

215 nses recorded in the absence and presence of uncoupler or from [Ca2+]c elevations evoked by uncoupler

216 s, inhibiting mitochondrial function with an uncoupler or interrupting the electron transport chain w

217 coupler or from [Ca2+]c elevations evoked by uncoupler or ionophore applied after complete Ca2+ mobil

218 be enhanced by treatment with mitochondrial uncouplers or dissipated by drug-induced disaggregation

219 re scrutiny as possible mitochondrial proton uncouplers or inhibitors of the electron transport chain

220 Remarkably, mitochondrial uncouplers or Na+ depletion prevent the ability of T cel

221 on mechanism distinct from that triggered by uncouplers or the apoptosis inducer staurosporine.

222 Ca(2+) and is not affected by ruthenium red, uncouplers, or ionophores that perturb transmembrane gra

223 ce of CN(-) or rotenone or the mitochondrial uncoupler p-trifluoromethoxyphenyl hydrazone (FCCP).

224 Na/K ATPase inhibitor ouabain and the myosin-uncoupler para-aminoblebbistatin to maintain constant en

225 ted by the CB1R antagonist rimonabant and Gi uncoupler pertussis toxin, and absent in Cnr1(-/-) RGCs.

226 Nonspecific membrane uncouplers prevent both succinate- and ATP-driven IMV ac

227 , cells were pretreated with a mitochondrial uncoupler prior to EGF stimulation.

228 revealed by preincubation with mitochondrial uncouplers prior to ATP treatment.

229 as substantially lower in the presence of an uncoupler (Q(10) = 1.61) than its absence (Q(10) = 2.08)

230 mparison, the neuronal-specific gap junction uncouplers quinine (250 microM) and mefloquine (500 nM)

231 DNP)-treated (protonophore and mitochondrial uncoupler) rats.

232 ligodendrocytes, exposure to a mitochondrial uncoupler recapitulated the phenotype of WMI, supporting

233 Uncouplers reduced pHi by 0.1 unit.

234 Treatment with FCCP, a mitochondrial uncoupler, reduced ROS levels and attenuated lipid perox

235 The effect of uncoupler reflects the collapse of an opposing potential

236 will review the small molecule mitochondrial uncouplers reported to date and explore their potential

237 Pharmacologic mitochondrial uncouplers represent a potential treatment for obesity t

238 s that target the proton motive force (PMF), uncouplers, represent one possible class of compounds th

239 ucers and blockers can be distinguished from uncouplers, respiratory inhibitors, and blockers of Ca(2

240 ATP depletion induced by a mitochondrial uncoupler resulted in similar alterations even in the pr

241 The uncouplers S13 and dinitrophenol showed that NarK2 was n

242 uncoupling via increased expression of SERCA uncouplers, sarcolipin and/or neuronatin, under chow-fed

243 s indicate that the relative contribution of uncoupler-sensitive mitochondrial hydrogen peroxide prod

244 mitochondrial polarization, as indicated by uncoupler-sensitive quenching of the red TMRM fluorescen

245 Secondly, it was uncoupler-sensitive, and thus triggered by the DeltapH a

246 ive phosphorylation as well as mitochondrial uncouplers serve as pharmacological controls, which help

247 s potential treatment of NASH, mitochondrial uncouplers show promise for future development.

248 Uncouplers showed a wide distribution of specificity on

249 reas the maximal rate of electron transport (uncoupler-stimulated respiration) was inhibited by appro

250 Mitochondrial uncouplers such as BAM15 increase respiration and energy

251 GFP channels exhibit slow gating by chemical uncouplers such as CO(2) and alkanols.

252 olated rod photoreceptors with the G protein uncoupler suramin or pertussis toxin, which inactivates

253 SHD865 is a milder mitochondrial uncoupler than BAM15 that results in a lower maximal res

254 e, we show that SR4 is a novel mitochondrial uncoupler that causes dose-dependent increase in mitocho

255 onyl cyanide m-chlorophenyl), a protonophore uncoupler that decreases mitochondrial Ca2+ uptake, decr

256 de m-chlorophenyl hydrazine, a mitochondrial uncoupler that induces mitophagy.

257 he antibiotic florfenicol is a mitochondrial uncoupler that prevents the production of reactive oxyge

258 in actually function as mitochondrial proton uncouplers that independently activate AMPK and concomit

259 Reciprocally, mitochondrial uncouplers that promote mitophagy reversed LPS/IFN-gamma

260 mitochondrial biogenesis and a mitochondrial uncoupler to enhance respiration synergistically drives

261 t muscle fibers treated with a mitochondrial uncoupler to increase electron flux, as occurs with exer

262 We also show the use of respiratory uncouplers to simulate ischemia in the single myocyte an

263 ve relied on high concentrations of chemical uncouplers to trigger mitochondrial depolarization, a st

264 zone (FCCP), a mitochondrial proton gradient uncoupler, to release mitochondrial free calcium ([Ca2+]

265 Small molecule mitochondrial uncouplers transport protons from the mitochondrial inne

266 Dietary RA and uncoupler treatment promoted tumor differentiation in an

267 Possible cytotoxicity by uncoupler treatment was evaluated by caspase 3/7 activit

268 rkin, combined with short-term mitochondrial uncoupler treatment, stimulates widespread mitophagy and

269 (JC-1) in the presence of substrates/ADP or uncouplers (valinomycin/carbonyl cyanide p-(trifluoromet

270 d mitochondria, no stimulation of the MPT by uncoupler was observed in the presence or absence of thi

271 alternative explanations for the effects of uncouplers were evaluated: (a) the 'back-pressure' of th

272 Thus, a new class of V-ATPase inhibitors (uncouplers), which are not simply ionophores, provided n

273 Mitochondrial uncouplers, which reduce the proton gradient across the

274 In the latter case, the uncouplers would decrease the RC time constant for membr