ライフサイエンスコーパス: undescribed

1 rized, but the DUX4-induced proteome remains undescribed.

2 ed angucyclines, 11 of which were previously undescribed.

3 l colonization of the primordial gut remains undescribed.

4 y including 6 compounds that were previously undescribed.

5 new source of PCB contamination, previously undescribed.

6 principles for these findings remain largely undescribed.

7 ctures of such trinaphthylenes were hitherto undescribed.

8 climatic drivers behind these changes remain undescribed.

9 hospitalized patient cohorts remain largely undescribed.

10 War II, that of the Pacific campaign remains undescribed.

11 as well as water-associated spiders largely undescribed.

12 n Clostridium difficile ST6 and a previously undescribed 310kb chromosomal replacement in Staphylococ

13 Previously undescribed [4.4.0] and [5.3.0] fused-ring-containing pr

14 on receptor and shed light on its previously undescribed activity against mobile genetic elements, su

15 These data demonstrate heretofore undescribed adaptations underlying the reversal of NAFLD

16 We sought to investigate the presence of undescribed allergens in ragweed pollen.

17 this inhibitor, which revealed a previously undescribed allosteric binding pocket.

18 his technique, we serendipitously identified undescribed anatomical and physiological respiratory fea

19 These data introduce a previously undescribed and counterintuitive prohypoxia role for pro

20 Of those, 30 taxa were determined to be undescribed and new to science, including members of fiv

21 nds in AMR mobility and determine previously undescribed and novel resistance variants.

22 le-strand break (DSB) initiates a previously undescribed and selective pathway of autophagy that we t

23 We report several previously undescribed and unexpected transcriptional responses wit

24 -diagram description, we reveal a previously undescribed anion-insertion mechanism occurring in Co an

25 ME-1 and GoM-Arc1) or previously genomically undescribed (ANME-2c) archaeal lineages.

26 identified genetic loci that could represent undescribed anti-adhesive targets.

27 orhoods for the identification of previously undescribed anti-defense systems.

28 interbacterial antagonism confers previously undescribed antibacterial capacity to eukaryotes.

29 Here, we localize 11 previously undescribed apical proteins in T. gondii and identify an

30 Using a previously undescribed approach involving single guide RNA, we succ

31 nd SCLC-Y), while the fourth is a previously undescribed ASCL1+ neuroendocrine variant (NEv2, or SCLC

32 tandem repeat expansions included previously undescribed ASD-linked expansions in DMPK and FXN, which

33 This study identifies a previously undescribed aspect of picornavirus replication complex s

34 individual, possibly indicating a previously undescribed association with UM pathogenesis.

35 ncer, and consistently identified previously undescribed associations between radiomic imaging featur

36 Previously undescribed associations include signals in or near GDAP

37 These results demonstrate previously undescribed astrocyte-mediated mechanisms in the pathoge

38 membrane phosphatidylglycerol, a previously undescribed bacterial-driven chemoattractant.

39 ing complex, we discover multiple previously undescribed basal complex proteins.

40 'super-complex' (2:2:4), using a previously undescribed binding motif in the Unc5D TSP1 domain.

41 nce, of transient phosphorylation, or in yet-undescribed biological contexts.

42 trometry approach, we show that a previously undescribed biomolecule, S-geranylgeranyl-L-glutathione

43 We precisely define a previously undescribed block during late terminal differentiation a

44 These data define a previously undescribed causative role for 3-HAA, which is a product

45 alkane/fatty acid oxidation in a previously undescribed class of archaea ('Candidatus Methanoliparia

46 diates, we exemplified the preparation of an undescribed class of carbocyclic nucleoside analogues an

47 ers of the FA pathway represent a previously undescribed class of selective autophagy genes that func

48 to genes, especially for rare or previously undescribed clinical entities.

49 was also developed to generate a previously undescribed co-factor, carboxy-S-adenosyl-l-ethionine (c

50 endent samples, we identified two previously undescribed coding variants associated with lower platel

51 tein turnover assay to discover a previously undescribed collaboration between membrane-embedded cyto

52 We also identified several previously-undescribed conserved genome contexts, providing insight

53 A brother and sister developed a previously undescribed constellation of autoimmune manifestations w

54 scovery and characterization of a previously undescribed copper center that forms the active site of

55 c repertoires include diverse and previously undescribed CRISPR-Cas systems, transfer RNAs (tRNAs), t

56 Here, we apply previously undescribed culture calibrations for the B/Ca proxy in p

57 nsferases, FamD1 and FamD2, and a previously undescribed cyclase, FamC1.

58 mic forebrain targets, and that a previously undescribed descending GABAergic pathway emanates from t

59 We identify a previously undescribed developmental role for the brain and reveal

60 tagenomic sequencing has revealed previously undescribed diversity within these functional groups, an

61 uncating variants in TPM4 cause a previously undescribed dominant Mendelian platelet disorder.

62 Our findings unveil a previously undescribed dual-regulation of neuronal excitability at

63 hat this VHH traps the virus in a previously undescribed early intermediate state.

64 sfunction and nitric oxide deficiency as yet-undescribed early manifestations of tau pathobiology, in

65 24 due to the presence of an unpredicted and undescribed effector binding site not present in the all

66 tions, which allowed the inference of as yet undescribed effector functions.

67 al LN stromal cells (mLNSCs) to a previously undescribed embryonic fibroblast activation protein-alph

68 about the kinetic isotope effects of as yet undescribed enzymes, thus to make predictions as to thei

69 ler groups of antibodies bound to previously undescribed epitopes in domain II of the E protein.

70 ion of mTOR signalling (including previously undescribed EWSR1 gene fusions), and telomere maintenanc

71 FT) calculations, we could verify the so-far-undescribed existence of two stable isomers in cyclic io

72 000 described and possibly up to one million undescribed extant species [1, 2].

73 s a wide catalog of somatically acquired and undescribed extrachromosomal circular DNAs.

74 nal analyses identified REV7 as a previously undescribed FA gene, which we term FANCV.

75 Our findings reveal a previously undescribed facet of adaptive evolution and suggest appr

76 ocots and eudicots, and highlight previously undescribed factors in lipid metabolism, transport and s

77 the developing brain and identify previously undescribed features of Akt phosphorylation and activati

78 Some patients showed previously undescribed features such as fluorescein-negative intrar

79 096 AA individuals identified two previously undescribed FI loci, chrX FAM133A (rs213676) and chr5 PE

80 g nine cell lineages, including a previously undescribed fibroblast lineage trajectory present in bot

81 flavones (1-4, 6-10, 12) and two previously undescribed flavones (5, 11).

82 idence for an alternative pathway previously undescribed for orthomyxoviruses, whereby the spread of

83 nt tissues and thereby serve as a previously undescribed form of adipokine.

84 cted through synapses that have a previously undescribed form of temporary, nitric oxide-mediated pla

85 We describe three distinct, previously undescribed forms of HA, most notably a 150 angstrom-lon

86 , we identified an unexpected and heretofore undescribed frequent occurrence of myeloid neoplasms amo

87 actor to its DNA target site is a previously undescribed function for a trans-acting noncoding RNA.

88 Here we show a previously undescribed function for NQO1 in stabilizing HIF-1alpha,

89 twork (WGCN) analysis suggested a previously undescribed function for PHYTOCHROME-mediated light sign

90 mbers of this cluster, identify a previously undescribed function for the miR-17 seed family in contr

91 lectively, our data demonstrate a previously undescribed function of HEV ORF3 as a viroporin, which m

92 This previously undescribed function of PHLPP1 depends on a bipartite nu

93 f organisms, and our work decodes a hitherto undescribed function of these classic hormones and sugge

94 WRN-DNA2-mediated resection and identify an undescribed function of WRN as a DSB repair pathway swit

95 ily of P2X receptors could have a previously undescribed functional role of trafficking partner prote

96 We elucidate previously undescribed functions for giant AnkG, including recruitm

97 Using classic (Wt1(Cre)) and previously undescribed (G2-Gata4(Cre)) transgenic mouse models for

98 lose synthase operons and several previously undescribed genes associated with cellulose production.

99 Here, to identify previously undescribed genes associated with developmental disorder

100 e virus represents a distinct and previously undescribed genetic lineage of Orthopoxvirus, which is m

101 One symbiont forms an undescribed genus in the Midichloriaceae (Rickettsiales)

102 aken together, our studies reveal previously undescribed glial roles in pioneer-axon guidance, sugges

103 ing the innervation, we found two previously undescribed head muscles (the processo-articularis and d

104 luding catalytic degradation to a previously undescribed heme derivative.

105 in the lymph gland, and discover previously undescribed hemocyte types including adipohemocytes, ste

106 Genetic analysis revealed a separate, undescribed heterozygous mutation (c.265G>A; p.A89T) in

107 exome sequencing, we identified a previously undescribed heterozygous mutation, n.37 C > T, in the se

108 oop kissing interactions) forming a hitherto undescribed, higher-order, G4-based secondary structure

109 d fecundity, and is a member of a previously undescribed host-responsive aphid gene family that opera

110 ew disease mechanism and produced previously undescribed human ZAP-70-associated autoimmune disease.

111 ed with immunotherapy to discover previously undescribed immunotherapy targets.

112 l activation of defence responses previously undescribed in eukaryotes.

113 , a dual neurotransmitter phenotype hitherto undescribed in the brain of any vertebrate.

114 ligands and for the discovery of previously undescribed, in vivo active chemotypes from structure-ba

115 , our results provide a wealth of previously undescribed insights into L. pneumophila pathogenesis an

116 elease is blocked and implicate a previously undescribed interaction between Rrp5 and the DEAD-box pr

117 eract with the membrane through a previously undescribed interface.

118 oupled receptor, traffics along a previously undescribed intracellular itinerary via the Golgi comple

119 This work reveals a previously undescribed invasive mechanism whereby the secretion of

120 Here we examine the previously undescribed iron(III)-coordinating and cellular iron-mob

121 We report many previously undescribed isoforms (human brain: approximately 13,800

122 n the levels of active Fur adds a previously undescribed layer of regulation in maintaining cellular

123 o Irish Traveller families with a previously undescribed lethal skeletal dysplasia characterized by f

124 e prone to become bone cells is a previously undescribed ligament.

125 le amphipathic helix present in a previously undescribed location in Atg20 within the putative BAR do

126 We identified six previously undescribed loci at which inherited variants predispose

127 nce in AA individuals, and sought previously undescribed loci through trans-ethnic (AA+EA) meta-analy

128 he biosphere and geosphere, and a previously undescribed macroevolutionary driver - earth system succ

129 introduce fibre recruitment as a previously undescribed mechanism by which cells probe and respond t

130 Our findings reveal a previously undescribed mechanism for interbacterial antagonism and

131 These findings illustrate a previously undescribed mechanism for interrupting faithful mitotic

132 We also reveal a previously undescribed mechanism for inverse agonism involving an o

133 We also report an as-yet-undescribed mechanism for lipase transport in eukaryotic

134 Our results show a previously undescribed mechanism for modulating spatial variation i

135 ion of the upstream transcript, a previously undescribed mechanism for rapid transcript induction.

136 Here, we reveal a previously undescribed mechanism named 'centromere disintegration'

137 Our findings highlight a previously undescribed mechanism of action for neuroligins and link

138 dependent manner, demonstrating a previously undescribed mechanism of action for PRL-3.

139 is discovery of POLGARF unveils a previously undescribed mechanism of de novo protein-coding gene evo

140 Our study identifies a previously undescribed mechanism of insecticide resistance that is

141 ults indicate that exosomes are a previously undescribed mechanism of intercellular communication in

142 p of marine arthropods [3], use a previously undescribed mechanism of internal O2 transport: flows of

143 f the acetyltransferase GCN5 in a previously undescribed mechanism of RA signaling in the developing

144 cancer cells, thereby revealing a previously undescribed mechanism of tumour suppression.

145 e aberrant M-GE signal operates a previously undescribed mechanism that reduces the expression of a m

146 This suggests fish may possess novel, undescribed mechanisms for salt detection.

147 compounds with both previously reported and undescribed mechanisms of action, including a series of

148 Our results establish a previously undescribed mechanosensor in endothelial cells that regu

149 results show that reovirus uses a previously undescribed, membrane-engaged, nonlytic egress mechanism

150 This previously undescribed metabolic heterogeneity of NSCLC subtypes im

151 , highlighting the existence of a previously undescribed metabolic variability in MLL-rearranged leuk

152 onverts the trihydrophenolic to a previously undescribed metabolite that directly inhibits TbetaRI ki

153 d with dysfunctional P2Y12R and a previously undescribed missense mutation in the encoding gene.

154 y upregulated cellular genes is a previously undescribed mode of host shutoff.

155 st modular ascarosides as well as previously undescribed modular glucosides.

156 rotocol, we identify and annotate previously undescribed molecular interactions between capsid subuni

157 Together, our findings identify a previously undescribed molecular mechanism of aPKC regulation, a mo

158 l protein, TRIM69, functions by a previously undescribed molecular mechanism.

159 These studies reveal previously undescribed motility behaviors and lend insight into how

160 tumor types, we identified >1,000 previously undescribed MS indels in cancer genes.

161 e formation may proceed through a previously undescribed multimembrane intermediate composed of vesic

162 dge, the presented structure is a previously undescribed mutant of the membrane protein VDAC, crystal

163 ene expression signatures (GESs), previously undescribed mutational profiles and their corresponding

164 Moreover, the model predicted new previously undescribed mutations as potentially responsible of drug

165 Known and previously undescribed mutations in BTK and PLCG2, or uncommonly, o

166 A previously undescribed Mycoplasma sp. sequence was found in two gui

167 f five fungal plant pathogens, 66 previously undescribed mycoviruses were identified.

168 e genome segments representing 66 previously undescribed mycoviruses.

169 on lineage analysis, we uncover a previously undescribed neural crest contribution to cardiomyocytes

170 Our findings suggest a previously undescribed neuronal exosomal miR-mediated genetic regul

171 We found a previously undescribed no-cross zone between afferent and efferent

172 A previously undescribed, noncanonical member of the NRPS condensatio

173 Finally, we identify two previously undescribed nuclear localization sequences in the DBD.

174 nformation, we have annotated 291 previously undescribed or only partially annotated transcript isofo

175 We describe the isolation of a previously undescribed organism, Herbinix spp. strain LL1355, from

176 or the detection of the many small and often undescribed organisms that represent the bulk of animal

177 However, ProPublica's use of a previously undescribed outcome measure (composite of in-hospital mo

178 nscriptomic evidence, including a previously undescribed paired box 8 (PAX8)-nuclear factor, erythroi

179 We discover four previously undescribed paired neurons, the primary protocerebral an

180 Here we present 12 previously undescribed patients and six novel pathogenic variants i

181 osure cases showed a distinct and previously undescribed pattern of interface astroglial scarring at

182 re importantly, our model reveals previously undescribed patterns, including an increased frequency o

183 the literature of hGLUTs, and two previously undescribed Phe amide-derived inhibitors.

184 e-wide approach by characterizing previously undescribed phenomena in affinity maturation.

185 ton structuring applications, we observed an undescribed phenomenon in photochemistry that dictates r

186 s mediated by Cdc7 kinase through previously undescribed phosphorylations on GINS that induce an asso

187 le myosin II (NMII) assemble into previously undescribed polyhedral-like lattices around the vesicle

188 the structural assignments of the previously undescribed polyketide analogues.

189 The potential of hitherto undescribed polyketides from P. malabarica as natural an

190 skin-draining lymph nodes, and a previously undescribed population in Peyer's patches (PP).

191 distances, which points out to a previously undescribed positional artifact.

192 data identified SUMOylation as a previously undescribed post-translational modification of STAT3 and

193 ity of the evolution of TTX resistance in an undescribed predator-prey relationship between TTX-beari

194 These previously undescribed prematurely cleaved and polyadenylated pre-m

195 C6On synthons as well as several previously undescribed products.

196 ograde tracing studies revealed a previously undescribed projection of the avian dorsal pallidum.

197 Network complexity, a previously undescribed property of the rhizosphere microbiome, appe

198 de V proteins (SCVPs), encoding a previously undescribed protein family.

199 e subunit and the small subunit are hitherto undescribed protein folds of unknown evolutionary origin

200 We identify three previously undescribed protein layers of the pyrenoid: a plate-like

201 teria share a gene that encodes a previously undescribed protein, named herein BefA (beta Cell Expans

202 and neurodegenerative roles for a previously undescribed protein, TMEM184b.

203 rotein concentrations, and detail previously undescribed protein-protein interactions.

204 10% of P. vivax genes encode multiple, often undescribed, protein-coding sequences, potentially incre

205 of structural proteins, known and previously undescribed proteins specific to cellular subsets and th

206 Recent work has linked a previously undescribed protist with mass-mortality events in the Un

207 ymnesin series as well as over 20 previously undescribed prymnesin-like molecular features.

208 er R shears, R' and P shears, and previously undescribed R' Riedel-in-Riedel relationships.

209 differentiation; and "MK-MEP," a previously undescribed, rare population of cells that are bipotent

210 mide synthesis pathway, lead to a previously undescribed recessive Mendelian disorder in the progress

211 Some appear to be the result of previously undescribed recombination events between ssDNA and ssRNA

212 t the stalk coiled-coils assume a previously undescribed registry during dynein's stepping cycle.

213 epression systems using known and previously undescribed replicative vectors.

214 ture allows us to uncover candidates for yet undescribed replicon genes, and to identify transposable

215 Using RiPPER, we show that previously undescribed RiPP gene clusters encoding YcaO and TfuA pr

216 These findings reveal a heretofore undescribed role for a Toll-like receptor in skeletal-mu

217 Together, these data identify a previously undescribed role for ABCs as potent APCs and suggest ano

218 ose-alanine cycling, and reveal a heretofore undescribed role for glucose-alanine in the regulation o

219 Our results reveal a previously undescribed role for Her9/Hes4 in photoreceptor differen

220 Our studies demonstrate a previously undescribed role for HoxA10 in terminating emergency gra

221 tory virus infection represents a previously undescribed role for ISG15 and demonstrates the importan

222 ollectively, our data provide evidence of an undescribed role for kisspeptin in integrating sexual an

223 Together, our data demonstrate a previously undescribed role for Mtb EsxA in mucosal invasion and id

224 These findings reveal a previously undescribed role for myosin in vesicle secretion and cel

225 Our results reveal a previously undescribed role for Notch in driving transitions during

226 lanation for this phenotype and a previously undescribed role for TCPs in the control of cell expansi

227 This demonstrated a previously undescribed role for wtHTT in maintaining normal macroph

228 (RBCs) may play an important but previously undescribed role in cardioprotection.

229 together, our data demonstrate a previously undescribed role of claudin-7 as a colon cancer suppress

230 ced increased fibrosis revealing a potential undescribed role of CXCR2 in CAFs.

231 nd ORRM3 on RNA editing reveals a previously undescribed role of RRM-containing proteins as mitochond

232 Herein, a previously undescribed role of saNOS in S. aureus aerobic physiolog

233 re hypersensitive to salinity, indicating an undescribed role of TRAPPs in stress responses.

234 to promote diversity, and suggest previously undescribed roles for motility in niche formation and co

235 Our results highlight previously undescribed roles of HIF1alpha and interactions among ma

236 K(+)-ATPase structures revealed a previously undescribed rotamer transition of the hydroxymethyl side

237 Our study reveals a previously undescribed route for the biogenesis of hydropolysulfide

238 ticipating the structures of five previously undescribed sarpagine-like N-oxide alkaloids that have b

239 and that this is achieved through previously undescribed sensory mechanisms for salt detection.

240 ur analyses revealed a high degree of so far undescribed sequences, suggesting a high number of unkno

241 Notably, our model reveals a previously undescribed set of interactions of the Arp2/3 complex wi

242 f exome studies, and also uncover previously undescribed sex differences.

243 ay library and demonstrate that a previously undescribed SG protein we term neutrophil stimulating fa

244 nalysis of these binary systems revealed yet undescribed signal intensity enhancement for the combina

245 es enrichment or depletion of the previously undescribed singleton TVRs TTCGGG and TTTGGG, respective

246 ylation and depalmitoylation of a previously undescribed site of modification, Cys-265 within the thi

247 These results identify previously undescribed sites at which glutamatergic and GABAergic i

248 holinergic system suggest the presence of an undescribed sleep state in the hippopotamus, as well as

249 ly lacked pigment and exhibited a previously undescribed small colony variant-like phenotype.

250 LCDCs also arborize in a previously undescribed small neuropil of the lateral protocerebrum.

251 ze in the lobula complex and in a previously undescribed small neuropil of the lateral protocerebrum.

252 lates were associated with novel, previously undescribed SNP lineages that were unique to each countr

253 matodes, while also implicating a previously undescribed source of chemical signaling.

254 (AhpD)/AhpC, using alpha-KG as a previously undescribed source of electrons for reductase action.

255 These findings underscore previously undescribed spatial metabolic heterogeneity in GBM biolo

256 latives of animals, we isolated a previously undescribed species (here named Choanoeca flexa sp. nov.

257 estimates were robust to the effects of both undescribed species and missing taxa.

258 ecies Hoilungia hongkongensis[1] and all yet undescribed species are morphologically indistinguishabl

259 gion V sequencing and represent a previously undescribed species within the M. terrae complex.

260 nd color forms that were analyzed (including undescribed species), 336 exhibit some morphological sim

261 polymorphic color forms and an additional 33 undescribed species.

262 methods support their inference as distinct (undescribed) species.

263 e morphological analysis of three previously undescribed specimens from the Pesciara deposit of Bolca

264 ng sensory processing, as well as previously undescribed spontaneous "plumes" of glutamate.

265 that the inhibitor AcrVA4 uses a previously undescribed strategy to recognize the L. bacterium Cas12

266 This study also revealed some so far undescribed structures, present at very low abundance.

267 These previously undescribed structures, termed endocardial flowers, have

268 e cells, follicle stem cells, and previously undescribed subpopulations of escort cells.

269 including identification of three previously undescribed subpopulations.

270 ncide A, and cimicifugolide, five previously undescribed substances, aruncins C, D, and E, and arunci

271 Our results identify insulin as a previously undescribed suppressor of YAP activity in insulin target

272 These findings add a severe, previously undescribed syndrome featuring erythrokeratodermia and c

273 We report and model a previously undescribed systematic error causing spurious excess cor

274 ith substantially different OS: a previously undescribed TERT-low/non-ALT cohort with superior OS (ev

275 t a noncanonical site, exposing a previously undescribed tethered ligand that triggers biased G-prote

276 N5 whose modification regulates a previously undescribed, tissue-specific mechanism of RA signaling t

277 show that these genes belong to a previously undescribed Toll subfamily and that members of this subf

278 We identified an undescribed tracheal occlusion (TO) at the posterior ext

279 Our findings reveal a previously undescribed transcellular pathway that links the integri

280 ed VSV(IND) replication through a previously undescribed transcriptional inhibition mechanism.

281 eam of the CD28 Vav motif induced previously undescribed transcriptional regulation of B lymphocyte-i

282 o the inner chloroplast envelope membrane by undescribed translocases.

283 strom resolution, which reveals a previously undescribed transmembrane protein fold.

284 hain assembly complex serves as a previously undescribed tumor suppressor in the liver, restraining T

285 in the motor path ECM depend on a previously undescribed two-step mechanism involving Hedgehog/Gli an

286 We also report a previously undescribed type of epithelial cell and the first ultras

287 We have identified a previously undescribed type of flavin enzyme that is exclusive to o

288 the outbreak strains belong to a previously undescribed variant, designated NAPCR1.

289 In addition, two previously undescribed variants (at positions 2083 and 2345 of the

290 We uncovered more than 3 million previously undescribed variants, most of which were found among ind

291 as, 37 orangutans and 2 gibbons and observed undescribed variation in great apes.

292 hen enabled the identification of previously undescribed variation in network architecture across spe

293 This discovery represents a hitherto undescribed vertebrate pathway that links luminance dete

294 This study identifies a previously undescribed viral mechanism for attenuating the host ada

295 olecular mechanisms involved in a previously undescribed virulence regulatory pathway of an important

296 disease symptoms, contained three previously undescribed viruses belonging to the Partititiviridae (A

297 l, this study documents known and previously undescribed ways that VREfm evolve during intestinal col

298 ahaliotrema mizellei and Metahaliotrema sp. (undescribed) were used to develop an automated technique

299 DNA from patients with CMN to reveal rare or undescribed Wnt-signaling alterations.

300 di-(3-methylbut-2-enyl)xanthone a previously undescribed xanthone and three triterpenes: ambonic acid