ライフサイエンスコーパス: undesired

1 notrophic methanogenesis, an outcome that is undesired.

2 lts from cytokine receptor pleiotropy and/or undesired activation of off-target cells.

3 ly, both CD4-17b CARs were devoid of a major undesired activity observed with the CD4 CAR, namely, re

4 e full advantage of carbon by mitigating the undesired activity.

5 Undesired adsorption of DNA to the surrounding non-targe

6 surface-based biosensors, the nonspecific or undesired adsorption of the probe is an important charac

7 ver, these hydrophobic tags typically induce undesired aggregation eliminating structural control, th

8 the dimerization tendency, which could cause undesired aggregation of target proteins; and (iv) the s

9 e often restrained by the solubility and the undesired aggregation-caused quenching effect of the hyd

10 eled the deactivation of secondary amines by undesired aldol reaction.

11 ctor to another, assuming that the former is undesired and the latter is desired.

12 erone has several desired effects as well as undesired and unknown effects.

13 ini interaction is a biomarker assay for the undesired androgenic responses in vivo.

14 of the CNS to contribute to the desired and undesired anesthesia end points.

15 e needed for antigen-specific suppression of undesired antibody responses, particularly to T cell-dep

16 iazines tested altered cell morphology, this undesired aspect was further investigated by exploring p

17 The induction of undesired autoimmune responses should be considered when

18 TiO2 (a-TiO2) on W:BiVO4/F:SnO2 blocks this undesired back reduction and dramatically improves the p

19 LDI with HDX has been challenging because of undesired back-exchange reactions during analysis.

20 ation (HePI-MS) source avoids, or minimizes, undesired back-exchange reactions usually encountered du

21 generally applicable to reduce or eliminate undesired background expression of transgenes.

22 process but also slows down the rate of the undesired background reaction.

23 while maintaining a relatively low degree of undesired base-loss products and internal products relat

24 to the Heck coupled product, and suppressing undesired beta-hydride elimination directly from the Pd(

25 carbene (NHC) ligand is effective to inhibit undesired beta-hydrogen elimination.

26 ized to favor the tricyclic product over the undesired bicyclic product resulting from diene metathes

27 hampered by severe side effects due to their undesired binding to healthy cells.

28 a disinfectant/cleaner generator that limits undesired biofilm formation and as a washing agent in wa

29 he K-index increase and the formation of the undesired biogenic amines.

30 indings will be useful either for preventing undesired bubble formation or, on the contrary, for "wri

31 were modulated to minimize the formation of undesired by-products.

32 l features, affecting the production of this undesired byproduct, as well as weak interactions respon

33 -53-fold higher ratio of desired HDR product:undesired byproducts.

34 Embedding in resin causes undesired C impurities.

35 ganic molecule can lead to the activation of undesired C-H bonds by a non-selective catalyst.

36 Ultimately, undesired C-N cyclization thwarted the final projected C

37 To avoid undesired cell death, this apoptotic pathway is tightly

38 s limitations by avoiding contributions from undesired cell types.

39 et-specific, and general method for removing undesired cells before transplantation.

40 ly)ethylene glycol diacrylate to encapsulate undesired cells in a hydrogel, allowing for retrieval of

41 In catalytic copolymerization, undesired chain transfer after incorporation of a polar

42 3(CF3)2 to the propagating catalyst prevents undesired chain-termination and -transfer processes.

43 tuning of the degradation profile results in undesired changes in other properties.

44 ulating microscopic objects without inducing undesired changes in structure.

45 l survival but if unrestrained can result in undesired chromosomal rearrangements.

46 eptavidin, for ultra-stable labeling without undesired clustering.

47 of the transporter led to severe toxicity or undesired CNS pharmacodynamic effects.

48 of protein variants inside cells, minimizing undesired coevolution and propagation of nonfunctional l

49 clease targets on homologous chromosomes, an undesired collateral effect that has not been described

50 may have counterintuitive, albeit temporary, undesired consequences.

51 tion could be safely used in vivo to inhibit undesired contact-dependent suppression by Tregs and, th

52 This labeling scheme largely eliminates undesired contributions to (13)C relaxation and greatly

53 particularly impactful, due to limiting the undesired coordination of 1-azadiene to the Lewis acid a

54 primers to amplify desired targets and avoid undesired cross reactions can be a combinatorial challen

55 produce a desired phenotypic outcome without undesired cross talk between c-di-GMP-dependent systems.

56 -care (POC) biosensor devices are limited by undesired cross-detection of other non-analyte proteins

57 ll activity but carries the risk of creating undesired cross-reactivity leading to potential serious

58 mediate specific interactions while avoiding undesired crosstalk.

59 crystals, excluding the possible presence of undesired CuO or Cu phases.

60 cetylide Cu-C bond rather than undergoing an undesired Curtius rearrangement.

61 le the C(2)-symmetric diastereomer favors an undesired Curtius-type rearrangement.

62 orbornene co-catalyst effectively suppressed undesired cyclopropanation pathways, which have previous

63 thy and pathological tissue, which can cause undesired damage.

64 MeCN/water can improve yields and reduce the undesired dealkylation side reaction.

65 as K(2)CO(3) and Na(2)CO(3) switch toward an undesired decarboxylative path.

66 for this reaction due to the possibility of undesired decarboxylative pathways and the susceptibilit

67 These conditions avoid the undesired decomposition of substrates with sensitive fun

68 agnitude, but this gain is accompanied by an undesired decrease in selectivity.

69 ver, the mechanism and factors affecting the undesired dehalogenation side reaction were revealed.

70 ts when they pass the grating walls, and the undesired dephasing may prevent interferometry with mass

71 desired detection by intended receivers and undesired detection from eavesdropping predators, prey,

72 ting in high levels of substrate-controlled (undesired) diastereoselectivity.

73 The SOMC methodology prevents undesired dimerization as encountered in solution and le

74 d stochastic block model tend to converge to undesired disassortative partitions.

75 disorders, and graft rejection by depleting undesired disease-causing T cells while keeping the over

76 if desired but may also present a problem if undesired dissociation occurs in the course of an experi

77 igning shaping-morphing materials that avoid undesired distractor states, expanding their potential a

78 optimizing the preparation processes wherein undesired doping is minimized could prompt the use of or

79 drugs and drug leads to it, possibly causing undesired drug-drug interactions.

80 me that is dwarfed by pervasive accompanying undesired editing events.

81 This undesired effect even becomes non-measurable if the hydr

82 esistance and point toward an unintended and undesired effect of chemotherapy.

83 Together, our results define an undesired effect of repeated GEM treatment promoting imm

84 th VEGF TrapR(1)R(2) treatment prevented the undesired effect of the FND procedure alone and signific

85 of TPB extract/kg of TTB did not exhibit any undesired effect on lactic bacteria which are necessary

86 ievement of these goals comes with potential undesired effects and risks including acne, alopecia, re

87 are micropollutants, compounds that produce undesired effects at low concentrations-as with the enzy

88 ernative approach would be to screen against undesired effects early in the process, but the number o

89 e ability of opioid drugs to produce serious undesired effects has been recognized for a similar peri

90 s with potent antidiabetic effects but fewer undesired effects is an active field of research.

91 gh anabolic activity in muscle while sparing undesired effects of benign prostate hyperplasia (BPH) a

92 vivo and how these relate to the desired and undesired effects of drugs.

93 ive or synergistic reward), compensation for undesired effects of one drug by taking another, compens

94 t efficacy after systemic administration and undesired effects preclude their use in routine pain the

95 tivity of a dual AI/SERM could attenuate the undesired effects stemming from global estrogen depletio

96 y common to attenuate basicity to circumvent undesired effects such as lack of biological selectivity

97 Given its analgesic properties and milder undesired effects than most clinically prescribed opioid

98 Heme only exerts these severe and undesired effects when it is not incorporated in hemopro

99 although it also produces some unintentional undesired effects, such as the formation of potentially

100 programming with the potential for extensive undesired effects.

101 ting protocols may potentially mitigate such undesired effects.

102 ntial for metabolic disease but also exhibit undesired effects.

103 tissues after prolonged exposure leading to undesired effects.

104 icides can enhance crop yields but also have undesired effects.

105 Undesired electrode-electrolyte interactions prevent the

106 x because of side effects resulting from the undesired enantiomer (distomer) and/or its metabolites,

107 f FR115427 and provides a way to recycle the undesired enantiomer in the synthesis of solifenacin.

108 to the pore rim prevents the passage of the undesired enantiomer while letting its mirror image thro

109 plet RP without significant competition from undesired energy transfer processes.

110 the key role of the electrolyte in limiting undesired energy-transfer reactions is highlighted by th

111 membranes can enhance the power density, but undesired entropy production due to uncontrolled mixing

112 thermal activation for H diffusion inhibits undesired environmental hydrogen pick-up during preparat

113 as dimethylaminopyridine (DMAP), may induce undesired epimerization of the alpha-carbon atom in poly

114 esulting ligand categories with frequency of undesired events reported to the pharmacovigilance progr

115 sitivity and dyslipidemia but do not enhance undesired fat storage.

116 imilar to the original clone, but lacked the undesired Fc-effects, and inflammation was attenuated fu

117 Undesired Fc-mediated functions, such as platelet activa

118 With regard to therapeutic applications, two undesired features of this phenotype in vivo are limited

119 he subsurface require novel means to control undesired fluid migration.

120 rst-generation catalyst system, suffers from undesired fluorination of electronically rich PODs resul

121 (TE) material is a double-edged sword-it is undesired for device operation in applications, but the

122 er, oxidized when exposed to air and lead to undesired formaldehyde emissions.

123 enge, resulting from the facile formation of undesired fully-oxidized CO(2).

124 crops, produce, and building materials from undesired fungal or bacterial growth.

125 at the DNA level to reduce the prevalence of undesired genes, minimize off-target effects and enable

126 We evaluated if there were undesired genomic effects of the PB transposon system to

127 owever, there has been limited evaluation of undesired genomic effects when using transposons for hum

128 tic modification of human cells with limited undesired genomic effects.

129 We developed procedures to remove the undesired genomic material from the VLP preparation and

130 logy mediated by these MHC molecules without undesired global immunosuppression.

131 As T cells play a key role in both undesired graft rejection and protection, a better under

132 develop potent and selective inhibitors for undesired GUSs.

133 e acting as a chaotropic agent that disrupts undesired H-bonding interactions, which was demonstrated

134 presence of grain boundaries in graphene is undesired, here we show that they have an ideal structur

135 ary C-centered radicals explains the lack of undesired homo- and direct coupling products (Ar-Ar, Ar-

136 ryogenic FIB milling can effectively prevent undesired hydrogen pick-up.

137 rimentally, and could be a strategy to avoid undesired hydrolysis of the donor substrate.

138 We find that the undesired hydroxylation byproducts, typically obtained i

139 ne (I2 ) as I3 (-) , this approach precludes undesired I2 -mediated decomposition which can otherwise

140 an lead to adverse patient reactions such as undesired immune responses.

141 lexes effectively dampen immune responses to undesired immunodominant bridging sheet determinants.

142 study reactions and to track the presence of undesired impurities.

143 ions are limited due to the low selectivity, undesired inactivation of beneficial bacteria and damage

144 e accumulation of free Sec in cells, causing undesired incorporation of Sec at Cys codons due to the

145 tives correlate with the minimization of the undesired induction period and offer insights for the de

146 enzymes that promote cancer progression and undesired inflammation under pathological conditions, ag

147 andin E(2) (PGE(2)) release and consequently undesired inflammatory responses and fever in vaccine re

148 Some cells discard undesired inherited components in bulk by forming large

149 tegration and develop strategies to mitigate undesired interactions between network components that a

150 nes are central in preventing aggregation or undesired interactions of flagellar proteins, including

151 h entropic cost of large-ring closure allows undesired intermolecular reactions to compete.

152 he rate of propagation (kp) but also prevent undesired intra- and intermolecular chain-transfer proce

153 In this case, however, an undesired intramolecular rearrangement pathway to the co

154 z transfer during the process prevents later undesired isomerizations in the adducts and keeps all he

155 However, the undesired Jahn-Teller effect of the Mn(4+) /Mn(3+) redox

156 d HaloTag ligand can be used as a blocker of undesired labeling, but this is not economical.

157 bic phase, suppressing the transition to the undesired lattice-mismatched phases.

158 The non-specific binding of undesired ligands to a target is the primary factor limi

159 enantioselectivity, as it likely discourages undesired ligation of benzoxazole substrates or intermed

160 optical resonances also give rise to strong, undesired light scattering.

161 e in white wine has been related to onset of undesired light-struck taste.

162 practical applications, as evidenced by the undesired lithium dendrite growth and unstable solid ele

163 , which was hypothesized to be the result of undesired liver uptake caused by poor physicochemical pr

164 ffect of inhibiting bacterial growth and the undesired, long-term effect of promoting the evolution o

165 d runoff RNA by suppressing the formation of undesired longer RNA byproducts.

166 or wear and tear, risking the exposure of an undesired material property.

167 ene expression in hybrid offspring following undesired mating events.

168 tightly regulated to prevent dehydration and undesired metabolic changes.

169 t channeling of intermediates and to prevent undesired metabolic cross-talk while maintaining metabol

170 The number of undesired microflora in mayonnaise preserved with lactob

171 hermore introduce a new constraint to filter undesired model behaviors induced by positive feedback l

172 quots of nanoRx formulations for desired and undesired molecular interactions.

173 surface area and readily adsorbs (sometimes undesired) molecular species.

174 al contact between sensor and skin minimizes undesired motion artifacts.

175 t zero velocity correctly, which would avoid undesired motion in a prosthetic application.

176 nzero velocity prediction, which would cause undesired motion when applied to a prosthetic arm.

177 ing daily activities can potentially promote undesired movements of the endovascular sealing structur

178 mtZFN, which limits off-target catalysis and undesired mtDNA copy number depletion.

179 rity <20 nucleotides in length, can decrease undesired mutagenesis at some off-target sites by 5,000-

180 n mono-allelic gene editing and avoidance of undesired mutagenesis.

181 he use of (Z)-nitroalkene substrates so that undesired nitroalkene isomerization is minimized and ena

182 ambient conditions, as OH dominates against undesired non-OH effects.

183 ally LAMP with two loop primers, suffer from undesired nonspecific amplification with strong backgrou

184 logical and biochemical analyses revealed no undesired NP-induced changes.

185 ing response of apes would have indicated an undesired object, either due to 1) the spatial arrangeme

186 edical applications has been hampered due to undesired off-target effects.

187 emical properties governing CNS exposure and undesired off-target pharmacology such as hERG interacti

188 cture and target concentration, and a set of undesired "off-target" complexes, each with vanishing ta

189 e of the constituent proteins to the risk of undesired oligomerization by reducing the concentration

190 macro(mono)cyclization (MMC) product and all undesired oligomerization products (O) resulting from ac

191 Despite its potential benefits, undesired or even detrimental effects of cannabis can li

192 the systemic circulation, where it may reach undesired organs.

193 ical thought processes that resulted in this undesired outcome and the transformation in our understa

194 ccount also documents how we adapted to this undesired outcome through an evaluation of several disti

195 ially pathological and could lead to various undesired outcomes such as DNA translocations, cellular

196 y and can cause suboptimal graft function or undesired outcomes.

197 nhibition resulted in inflammation and other undesired outcomes.

198 terruptions in care that are associated with undesired outcomes.

199 However, these additives may cause undesired parasitic reactions, such as the dissolution o

200 Furthermore, they show that this undesired pathway can be circumvented by changing from a

201 nergy between substrate and water suppresses undesired pathways but also that water promotes the desi

202 e new strategies that markedly suppress such undesired pathways to result in diverse aromatic compoun

203 esis-stimulating agents (ESAs) may result in undesired patterns of hemoglobin variability.

204 ally amphiphilic structures that may lead to undesired peptide interactions with blood proteins and s

205 cal evidence of suppressing the formation of undesired peroxide intermediate through plasmonic effect

206 ependent nature to suppress the formation of undesired peroxide intermediate.

207 r and subjective choices, and often involves undesired perturbation to the animals and their environm

208 multitude of quantitative data with minimal undesired perturbations.

209 to tandem solar cells(1) but suffer from an undesired phase transition near room temperature(2).

210 Current methods to assess undesired photo-induced cell changes rely on qualitative

211 nt, we decrease the susceptibility of FMN to undesired photoinitiated electron-transfer reactions tha

212 autologous blood recovery approach to remove undesired plasma or serum components of the donor blood

213 Second, undesired polymerization and coke formation prevail, lea

214 minates the side isobutene isomerization and undesired polymerization/coke reactions, resulting in th

215 yst poisoning or C-H functionalization at an undesired position, limits the application of C-H activa

216 s the stability of the particle and prevents undesired premature drug release until the shedding of t

217 y from stannylmethyl allyl ethers as a major undesired product in some Wittig-Still rearrangements ar

218 As a consequence, the pathway to the undesired product is strongly hindered, whereas that for

219 d-enantiomer (racemization), degradation to undesired products or tautomerization to other isomers.

220 Identification of a side product with undesired properties for final coating applications allo

221 polycrystalline thin films, which have some undesired properties such as large defective grain bound

222 cy of IgG and Fc fusion proteins could cause undesired properties.

223 To protect against undesired protein aggregation, living cells maintain a p

224 itored for errors to avoid the production of undesired protein variants.

225 Further, undesired protein-protein interactions can occur in a de

226 However, ketamine induces undesired psychotomimetic and dissociative side effects

227 multiples in preclinical evaluations against undesired pulmonary and cardiovascular effects.

228 ormance electrocatalysts usually demonstrate undesired quick degradation in MEAs.

229 epimerization of the P-chiral center of the undesired (R,R)-diastereomeric phosphine oxide 19 throug

230 Pitting corrosion, known as an undesired reaction destroying Al and is enhanced by anio

231 The protocol is optimized to avoid undesired reduction in binder diversity and enrichment o

232 s in a planar form tend to produce a strong, undesired reflection of sunlight, high-index nanostructu

233 ne intermediate is responsible for producing undesired regioisomers.

234 mely, increased potency and avoidance of the undesired rendering of the genetically modified CD8 T ce

235 the absorbers do not necessarily constitute undesired resistive heating problem for photovoltaics.

236 n those absorbers can enable the exchange of undesired resistive losses with the useful optical absor

237 specific nucleotidases protect cells against undesired salvage of m(7)GMP and its incorporation into

238 When amide hydrolysis is an undesired secondary reaction, as can be the case in the

239 troleum-based fuels and biofuels, can create undesired secondary water-quality effects.

240 reversibility, thus allowing the excision of undesired sequences.

241 oreover, rs4743771 is a major determinant of undesired serum cholesterol increases in rosi-treated di

242 defects into the host lattice, resulting in undesired shielding of the intrinsic role of dimensional

243 beta-cell SSC that have to be considered as undesired side effects because the influence of these co

244 e plants, its ectopic expression can lead to undesired side effects depending on the context of the s

245 e development of photodynamic therapy (PDT), undesired side effects like low tumor specificity and th

246 e been used in therapy despite a plethora of undesired side effects mainly attributed to the bacteria

247 itical tools for glycobiology, help to avoid undesired side effects of antivirals, and may reveal new

248 to improve treatment effects and prevent the undesired side effects on normal cells.

249 such as acute myeloid leukemia and to avoid undesired side effects when used in standard treatments.

250 ng alpha-amylase inhibition generally causes undesired side effects.

251 improved to increase efficacy and/or reduce undesired side effects.

252 ors, acts covalently, and is associated with undesired side effects.

253 e compounds to other isoforms and thus avoid undesired side effects.

254 ore selective therapeutic profiles and fewer undesired side effects.

255 ansport to the catalyst, we demonstrate that undesired side products such as H2O2 and O2(-) arise fro

256 competitive adsorption, ethanol prevents the undesired side reaction of beta-citronellene isomerizati

257 The occurrence of this undesired side reaction, which is previously unreported,

258 rd large biomolecules, which will help avoid undesired side reactions of drugs and expand the reperto

259 new catalysts have been designed to suppress undesired side reactions often encountered when these am

260 eagents are challenging to handle, engage in undesired side reactions, and function only within a nar

261 in some cases the applied conditions lead to undesired side reactions.

262 ency caused by mass transfer limitations and undesired side reactions.

263 rnative, yet their use remains sparse due to undesired side-processes.

264 ials are needed, reducing the probability of undesired side-reactions.

265 Since the undesired signals for the interfering compounds are supp

266 hydrogen, avoiding a hydride transfer to the undesired site and resulting in 100% atom economy.

267 selectivity, inasmuch as the nucleobase (an undesired site of reaction) is usually more nucleophilic

268 th its principal advantage and the source of undesired sneak-paths of current.

269 nd fluorescence, especially when it exhibits undesired spatial features, is a primary factor for redu

270 e cells but spontaneous dye loss resulted in undesired staining of cells.

271 bjective observation of patient symptoms and undesired stimulation effects while in the clinic.

272 chosen to account for how they are 'used' by undesired structures and not just by the desired structu

273 The different undesired structures present in these maps were identifi

274 Here, we find that such undesired structures rapidly degrade yield with increasi

275 conventional batch conditions in suppressing undesired symmetric ketone and tertiary alcohol byproduc

276 e ambient light required for growth leads to undesired system activation.

277 elution order of target components away from undesired tailing peaks and coelution spaces.

278 limited by imperfect selectivity (binding of undesired targets) and incomplete affinity (binding is r

279 torization, where current approaches have an undesired tendency to identify only a small number of th

280 ell carcinoma environment without unleashing undesired Th2 cytokines or IL10.

281 to cool the existing 2D crystals to prevent undesired thermal degradation and uncontrolled homogeneo

282 meliorate disease while limiting exposure at undesired tissues is an aspirational treatment scenario.

283 and on-target genome editing side effect in undesired tissues.

284 nately, therapeutic iron chelators also have undesired toxicity and may deliver iron to microbes.

285 In addition, HS20 had no detectable undesired toxicity in mice.

286 mple cover measurements can be used to avert undesired transitions and initiate restoration.

287 adiabatic pulses, dynamically counteracting undesired transitions.

288 unexpected paradigm in which a DUB prevents undesired ubiquitination to sharpen substrate specificit

289 Despite some undesired upconverted thermal noise, no noise is intrins

290 Furthermore, undesired uptake into liver cells was suppressed by usin

291 Our results support a general principle of 'undesired usage'-concentrations of components should be

292 The hole-hole homodimer is an undesired variant generated during the production of a b

293 DC library and leads to the creation of many undesired variants that can quickly outstrip screening c

294 Undesired vibrational excitation is avoided because of v

295 ion is increasing, especially for those with undesired visual acuity in the absence of photic symptom

296 the dissatisfaction patients, 42% (5/11) had undesired visual acuity without symptoms of glare/optica

297 e key reason for tropospherically-irrelevant/undesired VOC fate is that under some conditions, OH is

298 s drastically reduced while non-tropospheric/undesired VOC reactants are not.

299 termine the actual contamination level of an undesired wild-type enzyme.

300 res; while multi-drug resistant microbes are undesired yet prevalent, broadly-neutralizing antibodies