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6 he development of the Xpert MTB/RIF assay is undoubtedly a landmark event, clinical and programmatic
7 uld be expected to produce an equivalent, or undoubtedly a much greater, disruptive effect on mnemoni
16 on degeneration into diagnostic criteria has undoubtedly advanced diagnosis, but even earlier diagnos
19 al changes occurring during pain states will undoubtedly aid in the discovery of effective pain pharm
21 zing this newly identified bovine CD5L, will undoubtedly aid in understanding the role that the CD5-C
23 th miniaturized wireless wearable systems is undoubtedly an attractive prospect in the sense that the
24 shielding from loosely associated metals is undoubtedly an important influence during this metal-med
27 unanswered and new compelling questions will undoubtedly arise, the relative maturity of this field p
30 ellular differentiation and apoptosis, would undoubtedly assist their clinical development as antican
31 Mutations in mitochondrial DNA (mtDNA) are undoubtedly associated with a diverse spectrum of human
33 process has been modified over time and will undoubtedly be altered in the future to improve the proc
35 tigens using T cells from immune donors will undoubtedly be critical for the development of vaccines
37 ic understanding of autoimmune diseases will undoubtedly be helpful, meeting this challenge will requ
38 positions besides these diamagnetic ions can undoubtedly be made using a similar approach, which cons
39 ltimately successful vaccine strategies will undoubtedly be multifactorial, incorporating multiple an
40 s, airborne remote sensing technologies will undoubtedly be of major importance in optimized manageme
43 sential when, as was true with SARS and will undoubtedly be the case with future epidemics, scientifi
44 ir respective receptors within the skin will undoubtedly be the focus of future drug development for
47 and the experiment platform established will undoubtedly become a new paradigm for future research an
48 epsis in a rapid and quantifiable manner has undoubtedly been a major reason for the failure of many
50 Finally, although blood pressure lowering is undoubtedly beneficial, the concepts of single risk fact
52 nd the generation of epileptic seizures will undoubtedly benefit from research utilizing these connec
53 ing has resulted in new classifications that undoubtedly benefit patients and clinicians in their end
54 The ability to survive in diverse tissues is undoubtedly benefited by sensory pathways that recognize
57 is of fundamental importance, and this will undoubtedly broaden the scope of research on the chemist
58 ting genetic disease and safer methods would undoubtedly broaden the variety of possible illness that
61 ver, whereas amphetamine and methamphetamine undoubtedly cause irreversible brain damage with long-te
62 Although metabolic syndrome in adulthood is undoubtedly caused by multiple factors, including modifi
66 of the evolution of the malaria genome will undoubtedly clarify the current controversy, the importa
71 ity to systemic lupus erythematosus (SLE) is undoubtedly complex and, presumably, involves multiple l
74 scrutiny of velo-cardio-facial syndrome will undoubtedly continue for many years to come with the hop
75 ed many new concepts and therapies that will undoubtedly continue to be rapidly applied to the other
76 d to many existing antiviral agents and will undoubtedly continue to be the basis of future drug desi
77 matic overviews underscore that imaging will undoubtedly continue to dramatically shape the future of
78 known and newly emerging pathogens will also undoubtedly continue to enhance our understanding of the
81 ly understood, although genetic determinants undoubtedly contribute in substantial ways to the outcom
82 anding the functions of mosquito miRNAs will undoubtedly contribute to a better understanding of mosq
84 aracteristic of systemic lupus erythematosus undoubtedly contribute to the accelerated vascular disea
85 tion and multiple comorbid conditions, which undoubtedly contribute to their enhanced susceptibility
86 in which we practice, genetic variation will undoubtedly contribute to variability in therapeutic res
88 ineages in the marrow of colitis mice, which undoubtedly contributed to the anemia observed in these
89 facility pervasive in everyday life that has undoubtedly contributed to the success of our species.
90 esent in a diverse population of neurons and undoubtedly contributes to numerous functions in additio
92 ugh the intrinsic virulence of P. aeruginosa undoubtedly contributes to this phenomenon, it is unclea
94 PimA experiences remarkable flexibility that undoubtedly corresponds to the N-terminal "Rossmann fold
95 tween genetic and environmental factors will undoubtedly create new opportunities for public health a
97 hown that although the oligomeric chains are undoubtedly discrete and monodisperse, they nevertheless
98 chanism of protein complex dissociation will undoubtedly drive the technology into new areas of enhan
99 for this myopathy are evolving, function is undoubtedly driven by sequence variations and post-trans
100 number of different evolutionary niches has undoubtedly driven the high degree of phenotypic and gen
101 sympathectomy have been employed sparingly, undoubtedly due to potentially hazardous soft tissue con
105 The utility of the spiropyran switch will undoubtedly endow these materials with far-reaching appl
108 tributable, in part, to the scene chaos that undoubtedly exists, poor triage and missed diagnosis of
109 uture research on these new discoveries will undoubtedly expand our understanding of the role of EPCR
110 uture advances in technology and safety will undoubtedly expand the HIFU role in this indication as m
112 double-labeled glycopeptide standards, will undoubtedly facilitate future studies of glycopeptides a
113 hment of an authentic mouse model of DN will undoubtedly facilitate testing of translational diagnost
117 mulations that microfluidic technologies can undoubtedly fine-tune reaction times and reagents concen
119 juvant design and oral vaccine delivery will undoubtedly foster the development of effective fish vac
120 be fertile grounds for discoveries that will undoubtedly further broaden our understanding of the cat
124 rganisms to produce antibiotic resistance is undoubtedly going to outstrip availability of new antibi
126 fer of nuclear genes, and argue that HGT has undoubtedly had profound impacts on plant evolution as a
127 on within the framework of thin plate theory undoubtedly has a higher accuracy and broader scope than
128 CVD outcomes; the policies we explored would undoubtedly have additional beneficial effects upon othe
130 ri-, and posttransplantation clinical events undoubtedly have an impact on posttransplantation immune
131 te superior than their rival materials, will undoubtedly have an important impact within the near fut
132 nesis of this larval kidney form, which will undoubtedly have applicability to higher vertebrate kidn
135 e that all XGG and XAG (X = C or T) duplexes undoubtedly have structures similar to those of the 16-m
136 The design principles presented here will undoubtedly help achieve more conformationally stable he
138 our understanding of these systems and will undoubtedly impact development of future information tec
139 ized mercury (GOM) measurement uncertainties undoubtedly impact the understanding of mercury biogeoch
140 While siderophore-mediated Fe(III) uptake is undoubtedly important at early stages of infection, thes
141 gh a distinct, stable secondary structure is undoubtedly important in most noncoding RNAs, the stabil
142 nomic factors and therapeutic compliance are undoubtedly important issues in long-term allograft surv
144 pact of complex genetic interactions, though undoubtedly important, has received little investigation
145 sets within their physiological context will undoubtedly improve our understanding of normal hematopo
146 d intron presence/absence polymorphisms will undoubtedly improve our understanding of the evolution o
147 from gene expression profiling studies will undoubtedly improve the prediction of treatment response
149 ization of each medulloblastoma subtype will undoubtedly improve treatment of this disease and provid
151 f these assays to forensic laboratories will undoubtedly increase the sensitivity and specificity of
154 hape behavior, and emotion regulation - that undoubtedly influence important social and personal outc
155 t interspersed elements (SINEs) in mice that undoubtedly influence many developmental and homeostatic
157 eless, both B and T lymphocyte responses are undoubtedly influenced by Notch ligation, and defining t
158 erstanding how it becomes dysregulated, will undoubtedly inform the development of more efficient the
161 d array-based DNA sequencing technology will undoubtedly involve research and diagnostic analyses of
162 sis remain to be elucidated, the placenta is undoubtedly involved, as termination of pregnancy eradic
163 ut during infection is poorly understood but undoubtedly involves protein components within the surfa
164 ying regulation remains largely obscure, but undoubtedly involves steps after transcription initiatio
168 , and continued research in these areas will undoubtedly lead to better outcomes for transplant recip
169 e and continued research in these areas will undoubtedly lead to better outcomes for transplant recip
172 tion of these abnormalities as prerenal will undoubtedly lead to incorrect management decisions.
173 collaborative work between these worlds will undoubtedly lead to major discoveries and advances in cl
174 ology of this unique and versatile cell will undoubtedly lead to novel therapeutic approaches to meta
175 Scientific advances in these areas will undoubtedly lead to the development of more effective th
176 ch for TBPVs and that this kind of work will undoubtedly lead to the discovery of additional novel ti
177 ous uncharacterized T6SS effectors that will undoubtedly lead to the discovery of new biological mech
181 f de novo synthesis, an evolutionary outcome undoubtedly linked to obligatory growth in this metaboli
182 y (MS/MS) on protein-based therapeutics will undoubtedly make it a very valuable addition to the expe
184 d expression of p53, Rb, and Jun, as well as undoubtedly many other proteins may be a result of genom
188 nce of the nucleolus on nuclear organization undoubtedly modulates diverse biological processes from
190 onsible for over 40 monogenic disorders, and undoubtedly more pathogenic repeat expansions remain to
192 nephropathy (DN), a major cause of ESRD, is undoubtedly multifactorial and is caused by environmenta
193 d-coil structure with inherent plasticity is undoubtedly necessary to accommodate the dynamics of vir
195 mulation through these receptors, which must undoubtedly occur in vivo during antiviral immune respon
196 of plastic particles from the surface ocean undoubtedly occurs, the input exceeds the collective los
199 identify multiple loci with small effects is undoubtedly one of the primary reasons for this problem.
200 at while the function of LKB1 and STRADalpha undoubtedly overlap, they may also have mutually exclusi
204 ng on action choice and rewards received and undoubtedly play a pivotal role in maintaining and adapt
205 helical bundling in alpha- and beta-spectrin undoubtedly play a significant role in tetramerization,
206 ionary changes in transcriptional regulation undoubtedly play an important role in creating morpholog
207 s have revealed that, while gonadal hormones undoubtedly play an important role in sexual differentia
208 h factor for human mast cells, other factors undoubtedly play important roles in the development, sur
209 Although chromatin assembly and modification undoubtedly play major roles in the regulation of HSV-1
213 roperty for a replication initiation protein undoubtedly plays an important role in extending the hos
215 metrics, along with improved therapies, will undoubtedly present both familiar and new challenges in
216 gs of these complement-deficient mice, which undoubtedly prevented efficient gas exchange, causing de
217 ctions with Brca2 and Xrcc3, properties that undoubtedly promote its DNA repair capability in the cel
219 nsal E. coli isolate, E. coli HS, which will undoubtedly provide a new baseline from which workers ca
220 information learned from this accident will undoubtedly provide a synthesis of what has or has not b
221 ; however, investigation of this region will undoubtedly provide insight into the functional mechanis
222 rse genetic approach in the axolotl and will undoubtedly provide invaluable insight into the mechanis
223 Foreseeable, this sensor made on this basis undoubtedly provide the most effective and sensitive det
224 peer support elicited through the group FANC undoubtedly provided patients with additional tools to i
226 he basic virology of vector development will undoubtedly reap great rewards over the next decade in t
229 to optically tunable helical superstructures undoubtedly represent a striking example, owing to their
231 hough the aziridine residue of azinomycin is undoubtedly required for cross-link formation, analogues
233 ly promiscuous and regulatory mechanisms are undoubtedly required to ensure selective interactions.
235 tumors harbor immunosuppressive activity and undoubtedly restrict the effectiveness of these strategi
236 Further changes in its epidemiology will undoubtedly result from anticipated changes in the diagn
238 derstanding of mechanisms of cell death will undoubtedly result in the discovery of new drugs with po
240 ely, nonadherence to imatinib and other TKIs undoubtedly results in disease progression and treatment
241 tions of NK cell alloreactive functions will undoubtedly reveal additional roles and potential therap
242 nd non-canonical inflammasome complexes will undoubtedly reveal more surprises on their structure and
243 ntigen testing and prostate cancer treatment undoubtedly saves lives, there are growing concerns rega
244 ss cellular suicide if not murder, that will undoubtedly serve as a research base for many laboratori
247 20 m water depth) to the basement topography undoubtedly shaped by subaerial weathering and/or erosio
248 Interestingly, animal and plant LOX, which undoubtedly share a common ancestor, are related in sequ
249 g specificity in the nervous system and will undoubtedly shed light on many neural developmental diso
253 la melanogaster contain fewer genes than the undoubtedly simpler organism Caenorhabditis elegans?
258 n countries and regions of the world, and is undoubtedly the defining public-health crisis of our tim
260 ation became the favoured explanation and is undoubtedly the major factor driving the frequency chang
261 he specimen is relatively undistorted and is undoubtedly the most complete higher primate skull yet f
265 blood pressure reduction, statin therapy is undoubtedly the single most important risk factor interv
279 entral positive and negative feedback loops, undoubtedly to provide a greater flexibility and dynamic
280 of genome sequence and gene expression will undoubtedly transform biological research and spur the d
281 The bactericidal effects of antibiotics are undoubtedly triggered by target-specific interactions, b
282 ge of these viral proteins improves, we will undoubtedly uncover how the multifunctional nature of th
285 iable quantification of protein markers will undoubtedly underpin profound developments in disease su
286 into a single platform would be powerful and undoubtedly valuable for determining the full glycome of
289 likelihood of transmission via dentistry is undoubtedly very low, this may be amplified considerably
290 nteresting to note how medical records on an undoubtedly very ordinary citizen were recorded in Londo
293 ing the nature of linguistic representations undoubtedly will benefit from multiple types of evidence
295 The need for Epi-Aids of such outbreaks undoubtedly will persist as an integral part of future p
296 hemical performances is enhanced remarkably, undoubtedly, will have an important influence on the mat
298 lying the association of X. nematophila will undoubtedly yield insights into fundamental processes un
299 eterminants that maintain tumor growth, will undoubtedly yield more effective therapies for these can
300 chromatin regulates SMC differentiation will undoubtedly yield valuable insights into both normal dev