ライフサイエンスコーパス: unfavorable

1 her the benefit-risk profile is favorable or unfavorable.

2 orable profiles, 16% discordant, and 3% both unfavorable.

3 between GTP- and GDP-bound KRAS molecules is unfavorable.

4 deformation from the ground-state geometries unfavorable.

5 d toxins) where direct contact is limited or unfavorable.

6 -AA reversion is possible but evolutionarily unfavorable.

7 , while amide sp(2)O-sp(3)C interactions are unfavorable.

8 aking dyad assembly formation electronically unfavorable.

9 and with amide/aromatic sp(2)C are modestly unfavorable.

10 Such conformation prevents unfavorable 1,3-diaxial steric and electronic interactio

11 In conclusion, aHG was associated with unfavorable 3-month clinical outcomes in patients with a

12 th higher rates of delirium (62% vs 39%) and unfavorable 3-months outcome (27% vs 12%; all p = 0.005)

13 ection fraction <30% or screening suggesting unfavorable anatomy.

14 ic oxidation of methanol in an energetically unfavorable and atom-inefficient industrial process.

15 we discover that some mismatches are highly unfavorable and cannot be observed under the conditions

16 ng the ring-opening of glucose energetically unfavorable and leaving a high coverage of .OH radical o

17 ose with an initial favorable, questionable, unfavorable, and hopeless prognosis was 97.9%, 90.7%, 62

18 the latter case the BCB unit alleviated its unfavorable antiaromaticity more efficiently, leaving th

19 or propagation, whether they be favorable or unfavorable, are often transient.

20 lead to equally high health benefits, where unfavorable atmospheric conditions coincide with elevate

21 ntrinsic strengths of six favorable and four unfavorable atom-atom interactions, expressed per unit a

22 d transport model accuracy, especially under unfavorable attachment regimes, which is a current and c

23 3P reveals heightened discrimination against unfavorable AUG context genome-wide.

24 esponse; and of 27 patients with informative unfavorable baseline circulating tumor cells >= 5/7.5 mL

25 Favorable change combined with unfavorable baseline still corresponded with a lack of d

26 vels of liver stiffness and platelet counts (unfavorable Baveno VI status).

27 he time of PHT progression, all patients had unfavorable Baveno VI status.

28 hile amide sp(2)O-alkylurea interactions are unfavorable, becoming more unfavorable with increasing a

29 ) were assigned two cycles, 21 patients (any unfavorable biologic feature without 1p or 11q LOH) were

30 ival compared with patients with one or more unfavorable biologic features (n = 47; 86.9% [95% CI, 78

31 utcomes for patients with symptomatic and/or unfavorable biology 4S neuroblastoma with a uniform trea

32 were assigned four cycles, and 11 patients (unfavorable biology including 1p and/or 11q LOH [n = 7]

33 strategies still are needed for infants with unfavorable biology stage 4 disease.

34 ere enrolled: 41 were symptomatic and 28 had unfavorable biology.

35 re a result of late relapse in patients with unfavorable biology; and two were a result of treatment

36 markers, lower levels of adiponectin, and an unfavorable blood lipid profile (p < 0.001).

37 witter-ionic strategy stabilizes the usually unfavorable boat TS that can potentially evolve into rar

38 Gestational diabetes is associated with unfavorable body fat distribution in offspring.

39 haotic nature of multiphase flows as well as unfavorable boundary layer structures.

40 studies have linked low vitamin D status to unfavorable cardiometabolic risk markers, but double-bli

41 ns of plasma choline were associated with an unfavorable cardiometabolic risk-factor profile [lower h

42 one of the major causes responsible for the unfavorable carrier dynamics in conventional semiconduct

43 ling of IR dose-response reveals that the CO-unfavorable center region encompasses up to 6% of the to

44 Upon attenuation of this unfavorable change in enthalpy by cosequestration of pro

45 that this species experienced a significant unfavorable change in its foraging areas.

46 nce of lithium ion electrodes is hindered by unfavorable chemical heterogeneities that pre-exist or d

47 ently reported for patients with early-stage unfavorable cHL treated in the German Hodgkin Study Grou

48 f favorable PBRM1 mutations and enriched for unfavorable chromosomal losses of 9p21.3, as compared wi

49 rs for adverse bereavement outcomes included unfavorable circumstances of the patient's death.

50 e petrous bones of the 2 individuals despite unfavorable climatic conditions.

51 BACKGROUNDProteinuria is considered an unfavorable clinical condition that accelerates renal an

52 ed MCD/C5 tumors as specific ABC-DLBCLs with unfavorable clinical outcome, activating mutations in th

53 ng malignant progression of cancer cells and unfavorable clinical outcomes, which may represent possi

54 e absence of activated NK cells and predicts unfavorable clinical outcomes.

55 enables proliferation and survival in these unfavorable CO(2) environments.

56 The data indicates that unfavorable combinations of lifestyle risk factors lead

57 16, 0.026 SD/allele; P = 3 x 10-15) and with unfavorable concentrations of blood lipids (higher LDL c

58 ptake, whereas the low regime represented an unfavorable condition (low temperature and high salinity

59 During unfavorable conditions (e.g. tumor hypoxia or viral infe

60 ombustion conditions in a log wood stove and unfavorable conditions in the other devices induce, howe

61 icrobial groups are not only able to survive unfavorable conditions over geological timescales, but c

62 By entering G0, cancer cells survive unfavorable conditions such as chemotherapy and cause re

63 hile epidemics in most years were limited by unfavorable conditions with respect to one or more facto

64 reversibility with increased roughness under unfavorable conditions, necessitating inclusion of nanos

65 mparing humans with chimpanzees placed under unfavorable conditions, the authors suggest many uniquel

66 pheromone signaling to prevent mating under unfavorable conditions.

67 ges morphology from helical to coccoid under unfavorable conditions.

68 colloid attachment under both favorable and unfavorable conditions.

69 mature germination and seedling growth under unfavorable conditions.

70 brain insulin resistance in obesity may have unfavorable consequences for whole-body glucose homeosta

71 tional independence rates, but those with an unfavorable CTP had higher adverse outcomes.

72 In favorable CT/unfavorable CTP profiles, EVT was associated with high s

73 zation, and high chemical reactivity induces unfavorable dendrite effects.

74 g of the immune system during infection, the unfavorable development of chronic inflammation and tumo

75 has been considered a particularly grim and unfavorable disease complication, associated with substa

76 Although unused livers frequently have unfavorable donor characteristics, there are also system

77 t adaptations to move through areas that are unfavorable due to dominant competitors might promote th

78 ke wild dogs) to move through areas that are unfavorable due to humans.

79 The unfavorable effect of antibiotic exposure for subsequent

80 that the incorporation of FH had a slightly unfavorable effect on bread sensory properties but ensur

81 Importantly, FIS1 has no unfavorable effect on fruit weight or taste, making it a

82 Abdominal adiposity may have a causal, unfavorable effect on plasma triglycerides and potential

83 A less unfavorable effect on the bioaccessibility was exerted b

84 didate compounds for potential favorable, or unfavorable, effects on melanoma-associated gene express

85 r both favorable (energy barrier absent) and unfavorable (energy barrier present) conditions in an im

86 surements show the compounds with n > 7 have unfavorable enthalpies of formation (DeltaH (f)), sugges

87 th their synthesis, principally owing to the unfavorable entropy and transannular strain.

88 genes that contribute to acclimation to this unfavorable environmental condition.

89 (WD) enables plants to maintain growth under unfavorable environmental conditions, although the mecha

90 ncreasing crop production under a variety of unfavorable environmental conditions.

91 tem-dependent colonization, thereby avoiding unfavorable environments abundant in this toxic metaboli

92 Index, odds ratio, 1.98; CI, 1.15-3.41) and unfavorable EP (any limitation in >=3 daily activities,

93 through shielding these artificially exposed unfavorable epitopes.

94 actions to be linked together to overcome an unfavorable equilibrium or avoid the accumulation of uns

95 firmly engages them during the energetically unfavorable extraction process remains a mystery.

96 ic) relative vorticity anomalies and thus an unfavorable (favorable) environment for TC genesis.

97 each system, we highlight the favorable and unfavorable features and summarize the strategies utiliz

98 r bathing cells while keeping them away from unfavorable fields and forces in the vicinity of the ele

99 of the lipid membrane, which would be highly unfavorable for a negatively charged nucleophile, thus h

100 ive-year transplant-free survival rates were unfavorable for cluster 1 (47.6%; 95% CI, 35.4%-64.1%) a

101 the stromal microenvironment, which makes it unfavorable for established liver metastasis to grow.

102 icates that the degree of constraint is more unfavorable for further evolution along the same traject

103 contribution of microbial residues might be unfavorable for the stability of SOC in N-rich and P-poo

104 urfaces of subunit vaccines contain epitopes unfavorable for vaccine efficacy.

105 ratio, 1.78; 95% CI, 1.01-3.15; I = 43%) and unfavorable Glasgow Outcome Scale (risk ratio, 2.49; 95%

106 The outcome was unfavorable (Glasgow outcome scale score, <5) in 24 epis

107 ner independence are largely attributable to unfavorable governance arrangements and non-participatio

108 caused limited decay so far, probably due to unfavorable growth conditions.

109 ment of endoplasmic reticulum (ER) stress in unfavorable growth conditions.

110 oung children from low-income countries with unfavorable growth patterns.

111 no diabetes mellitus), 0 high RF but some RF unfavorable (>=1 RF above low-risk threshold but below h

112 Many plant species respond to unfavorable high ambient temperatures by adjusting their

113 Girls with the unfavorable (high VAT/[VAT + SAT]) phenotype exhibited h

114 ired or impending organ dysfunction, or with unfavorable histology and/or diploid DNA index, were eli

115 avorable histology, hyperdiploid stage 4, or unfavorable histology stage 3 tumors were eligible.

116 rable histology WTPDX are sensitive, whereas unfavorable histology WTPDX are resistant to conventiona

117 of the disorder that together result in an "unfavorable" host cellular environment that may interfer

118 t an incremental cost of $30747, yielding an unfavorable ICER of $154684 per QALY.

119 of established memory to pathogens may reset unfavorable immune responses.

120 A higher age and larger defects have an unfavorable impact on postoperative complications and a

121 Contact resistance is renowned for its unfavorable impact on transistor performance.

122 Risk was early favorable in 62% and unfavorable in 38%.

123 The outcome was unfavorable in 8 episodes (12%) and no patient died.

124 phosphate is that they are thermodynamically unfavorable in aqueous conditions.

125 s, CK should not be axiomatically considered unfavorable in CLL, representing a heterogeneous group w

126 lt due to the reason that wetting is usually unfavorable in the carbon/metal system.

127 t that proton transfer becomes energetically unfavorable in the presence of additional hydrogen bonds

128 The unfavorable in vivo performance may result from high pla

129 ions and sp(2)O-sp(3)C interactions are more unfavorable, indicating the preference of amide sp(2)O t

130 ydrate and sugar intakes are associated with unfavorable infancy BMI peak characteristics and higher

131 e, we identify and validate a prognostically unfavorable influence of Gremlin-1 production by fibrobl

132 imulations than experimentally in water, and unfavorable interactions are relatively uncharacterized.

133 be quantitatively explained on the basis of unfavorable interactions between KGlu and the functional

134 the protein GB1 mutant, we can avoid strong unfavorable interactions between protein and graphene to

135 sic, more sterically congested NHOs minimize unfavorable interactions by partly pyramidalyzing the ni

136 e functionality of AuNPs, causing strong and unfavorable interferences.

137 se; and grade group 3 or higher, cancer with unfavorable intermediate risk or worse.

138 forty-four patients, exhibiting at least one unfavorable intraosseous defect, were treated by L-PRF a

139 A commonly used definition of an unfavorable iPET result according to the Deauville score

140 e greater than that of the liver, whereas an unfavorable iPET scan with regard to the DeltaSUV(max) a

141 e for fast and efficient folding by avoiding unfavorable kinetic traps.

142 hlights the remarkable transformation of the unfavorable lead into "druglike" compounds guided by sys

143 le amount of confined water is energetically unfavorable leading the enhancement of self-healing effi

144 ferent-sex borrowers seem to experience more unfavorable lending outcomes overall.

145 red with 1.78% (95% CI, 1.38%-2.28%) with an unfavorable lifestyle (hazard ratio, 0.68 [95% CI, 0.51-

146 ut cognitive impairment or dementia, both an unfavorable lifestyle and high genetic risk were signifi

147 Four traditional unfavorable lifestyle factors were included: smoking, he

148 f the outcome in each genetic risk category; unfavorable lifestyle increased the risk of late AMD at

149 he participants with a high genetic risk and unfavorable lifestyle, 1.78% (95% CI, 1.38%-2.28%) devel

150 intermediate lifestyle, and 8.2% followed an unfavorable lifestyle.

151 ategorized into favorable, intermediate, and unfavorable lifestyles.

152 between enhanced protein packing and weakly unfavorable lipid desolvation, or solely by favorable li

153 as caused by lack of patient cooperation, an unfavorable location, or mydriasis.

154 ransition-state geometries that minimize the unfavorable lone-pair repulsion between neighboring nitr

155 nst HLA class II antigens is associated with unfavorable long-term cardiovascular outcome in KTRs ind

156 sed periprocedural major adverse events, and unfavorable long-term clinical outcomes compared with no

157 Problematic asthma patients with unfavorable long-term disease trajectory and persistentl

158 Either mechanism portends unfavorable long-term outcomes including risk for recurr

159 a was seen in half of patients and predicted unfavorable long-term QOL and EP.

160 Freeze-thaw, known as an unfavorable lysis method resulting in possible RNA fragm

161 missed, misdiagnosis or late diagnosis have unfavorable medical implications.

162 Thus, initial unfavorable metabolic changes including insulin resistan

163 In brief, higher VAT was associated with an unfavorable metabolite profile in a sample of healthy, m

164 Tumors adapt to an unfavorable microenvironment by controlling the balance

165 death) at 3 months; favorable (mRS, 0-3) vs unfavorable (mRS, 4-6).

166 ic disease that results from accumulation of unfavorable mutations.

167 Even though unfavorable neurological outcomes are amongst the most c

168 marker of poor outcome and a major basis for unfavorable neurological prognostication.

169 frequent after cardiac arrest, despite early unfavorable neurophysiologic signs and is associated wit

170 enters, stabilize OER intermediates that are unfavorable on pure M-M centers and single Fe sites, fun

171 ing valence-based responses to favorable and unfavorable options requires judgments of the relative v

172 tems: the alpha-systems suffer less from the unfavorable orientation of bond dipoles in the equatoria

173 presence of both a strong TAD border and an unfavorable orientation of CTCF sites.

174 centration was independently associated with unfavorable outcome (adjusted incidence rate ratio [aIRR

175 nterval [CI], 1.78-5.52) and greater odds of unfavorable outcome (adjusted odds ratio [aOR], 1.44; 95

176 ociated with a significantly reduced risk of unfavorable outcome (HR 0.90 [0.38; 2.1], p = 0.81).

177 An unfavorable outcome (i.e., either liver or surgical comp

178 ower limit of reactivity was associated with unfavorable outcome (odds ratio %cerebral perfusion pres

179 g, wound infection, and pneumonia) with each unfavorable outcome [ie, in-hospital mortality, organ fa

180 -to-treat analysis, 11 patients (10%) had an unfavorable outcome and 98 patients (90%; 95% confidence

181 Important risk factors for an unfavorable outcome are preoperative pain, existing risk

182 or early metastases are not associated with unfavorable outcome compared to late metastases.

183 organ graft and conversely in whom a rather unfavorable outcome is expected because of high donor ag

184 organ graft and conversely in whom a rather unfavorable outcome is expected due to high donor age.

185 uational risk factors which may determine an unfavorable outcome of the acute anaphylactic episode an

186 Unfavorable outcome rates were 64% (7/11) compared with

187 patients with none of these features had an unfavorable outcome versus 32% and 64% when one or two o

188 After controlling clinical covariates, unfavorable outcome was independently associated with ab

189 Unfavorable outcome was observed in 19%; a 1-mug/mL decr

190 Factors related to unfavorable outcome were age >18 years; activated B-cell

191 tween SN and ECN compared with patients with unfavorable outcome, an effect that was maintained after

192 he primary end point was the incidence of an unfavorable outcome, defined as treatment failure (bacte

193 The primary endpoint was time to unfavorable outcome, defined as: death, admission to an

194 no intervening positive culture or previous unfavorable outcome.

195 epilepticus is independently associated with unfavorable outcome.

196 tral valve features were risk factors for an unfavorable outcome.

197 associated with increased risk of death and unfavorable outcome.

198 CN amplification is strongly associated with unfavorable outcome.

199 is excellent, 5% to 10% of tumors display an unfavorable outcome.

200 not already been classified as having had an unfavorable outcome.

201 were associated with an increased risk of an unfavorable outcome.

202 h lower log-transformed drug concentrations, unfavorable outcomes (composite of treatment failure, al

203 itiation were compared between 68 cases with unfavorable outcomes (treatment failure, death or recurr

204 enation-related risk factors associated with unfavorable outcomes after extracorporeal cardiopulmonar

205 Unfavorable outcomes after trachomatous trichiasis (TT)

206 (LT) recipients may be at increased risk of unfavorable outcomes from COVID-19 due the high prevalen

207 CXCL1 was associated with decreased risk of unfavorable outcomes in unadjusted and adjusted analyses

208 Unfavorable outcomes included repeat surgery and induced

209 Unfavorable outcomes occurred in 35 of 146 (23.9%) patie

210 th favorable outcomes; patients with BSP and unfavorable outcomes showed either no features, transien

211 -19, no significant reduction of the risk of unfavorable outcomes was observed with hydroxychloroquin

212 The 11 unfavorable outcomes were 7 deaths (6 during treatment a

213 ory distress on admission is associated with unfavorable outcomes.

214 l procedures such as vitrectomy resulting in unfavorable outcomes.

215 ith latent RHD and identify risk factors for unfavorable outcomes.

216 between nucleotide-favorable and nucleotide-unfavorable P-loop conformations that predict experiment

217 in discordant profiles and 0% when both were unfavorable (p < 0.001 for trend).

218 neuronal calcium sensor 1 (NCS1) predict an unfavorable patient outcome in several aggressive cancer

219 cantly associated with higher CRC stages and unfavorable patient prognosis, in support of a potential

220 ral health changes over time, 2) the role of unfavorable patterns of dental visiting on oral health,

221 n the cohort period presented higher risk of unfavorable periodontal outcomes (rate ratio [RR]: 1.45

222 at this change results from an enthalpically unfavorable perturbation of the solvent network.

223 tting transition, making them susceptible to unfavorable perturbations.

224 feration in both depots in the metabolically unfavorable phenotype.

225 y pain-related receptors but can suffer from unfavorable physicochemical properties, which limit thei

226 ed HA from C15, which is a thermodynamically unfavorable position.

227 bility of ribosomal proteins by neutralizing unfavorable positive charges and thus facilitate their t

228 We also find that the strength of the unfavorable potential needed to trigger dewetting is rou

229 s barrier for proton transfer arises from an unfavorable preassociation of the proton donor with the

230 fluids from oil and gas extraction can have unfavorable precision and accuracy, in part because thes

231 It is a kinetically unfavorable process that is templated in the cell by the

232 er odds of hypertension and diabetes) and an unfavorable profile (higher LDL cholesterol and triglyce

233 ated to a lower risk of dementia compared to unfavorable profiles.

234 sent, patients with NPM1(mut) share the same unfavorable prognosis as patients with NPM1 wild type an

235 common cause of neurological impairment and unfavorable prognosis in patients with subarachnoid hemo

236 ression of 11 complement genes was linked to unfavorable prognosis in renal cell carcinoma.

237 Unfavorable prognosis is attributed to insufficiently ch

238 usions have prognostic implications, such as unfavorable prognosis of PAX3-FOXO1 fusion in alveolar r

239 ociated with microvascular density (MVD) and unfavorable prognosis of PHCCA in both retrospective and

240 reflux cholangitis indicated recurrence and unfavorable prognosis of PHCCA.

241 venty-seven percent (37/48) of patients with unfavorable prognosis were male.

242 erally associated with treatment resistance, unfavorable prognosis, and the infiltration of pro-tumor

243 ight chains (LCs), and is associated with an unfavorable prognosis.

244 y to patients with RMS in first relapse with unfavorable prognosis.

245 in cancer is the harbinger of a particularly unfavorable prognosis.

246 ere significantly higher in patients with an unfavorable prognosis.

247 holangitis could predict high recurrence and unfavorable prognosis.

248 particularly aggressive and associated with unfavorable prognosis.

249 with cytogenetic abnormalities presenting a unfavorable prognosis.

250 ors, and elevated RRS1 levels correlate with unfavorable prognosis.

251 sented TFs correlated with poor survival and unfavorable prognostic markers.

252 s; activation of these pathways exhibited an unfavorable prognostic value in a cohort of breast cance

253 a similar position as the WT residue, where unfavorable proximity to the RNA phosphodiester could ex

254 ltivariable analysis, elevated Zva predicted unfavorable QOL (lower EuroQOL-5-dimensions-Utility Inde

255 phosphorylation could have occurred despite unfavorable rates in bulk solution.

256 ate cob(II)alamin geometry, facilitating the unfavorable reduction to cob(I)alamin.

257 nt for membrane proteins in nanodiscs due to unfavorable relaxation properties of the slowly tumbling

258 ent between favorable (repulsion absent) and unfavorable (repulsion present) conditions through a com

259 s, and serum levels of this marker predicted unfavorable responses to neoadjuvant chemoradiation in E

260 vestigators, who may be inclined to withhold unfavorable results or even tamper with data in order to

261 e-median mitotic counts were associated with unfavorable RFS in the 1-year group but not in the 3-yea

262 ced-stage (defined as III to IV and IIB with unfavorable risk factors) cHL were eligible for Cohort D

263 ollowing SCI, yet was discontinued due to an unfavorable risk-benefit ratio associated with off-targe

264 Group 1-2) prostate cancer and 619 men with unfavorable-risk (clinical stage cT2cN0M0, PSA of 20-50

265 ptions, and men undergoing prostatectomy for unfavorable-risk disease reported worse sexual function

266 For men with unfavorable-risk disease, EBRT with ADT was associated w

267 n deprivation therapy (n = 217) for men with unfavorable-risk disease.

268 t approaches for men with favorable-risk and unfavorable-risk localized prostate cancer could inform

269 Insects often overcome unfavorable seasons in a hormonally regulated state of d

270 metabolism was the strongest predictor of an unfavorable seizure outcome, associated with a 5-fold in

271 E2 and S(N)2, respectively, to a supposedly unfavorable shift in the polarity of the abstracted beta

272 helix helps to stabilize this energetically unfavorable state to enable long-chain synthesis to occu

273 tertiary-C(sp(3))-C bonds, presumably due to unfavorable steric interactions and competing isomerizat

274 with various clinical manifestations and an unfavorable survival rate.

275 DNA bases can adopt energetically unfavorable tautomeric forms that enable the formation o

276 The unfavorable taxa Psychrobacter, Corynebacterium, Actinob

277 all p < 0.01): no patient had greater than 2 unfavorable tests.

278 hat systemic application of disaccharides is unfavorable, the extended biological half-life of the GB

279 able mixture of substrate and product due to unfavorable thermodynamic equilibria.

280 ne-cycloalkane pairs currently is limited by unfavorable thermodynamics for hydrogen release.

281 a sacrificial hydrogen acceptor to overcome unfavorable thermodynamics.

282 nd removal of the SDA to avoid energetically unfavorable three-rings.

283 However, if conditions are unfavorable through the second larval stage, worms enter

284 onds and changing the secondary H-bonds from unfavorable to favorable.

285 and develop a risk score to predict the most unfavorable trajectory.

286 e transport of ions to the thermodynamically unfavorable transport of neurotransmitter back into pres

287 chemokines could also serve as biomarkers of unfavorable treatment outcomes in PTB is not known.

288 XCL10 were associated with increased risk of unfavorable treatment outcomes in the validation cohort.

289 qualitative and control measures to correct unfavorable trends specific to an infection area have be

290 ms secondary to massive hepatomegaly or with unfavorable tumor biology are at high risk of death.

291 f assessing serum IL-8 levels in identifying unfavorable tumor immunobiology and as an independent bi

292 r motifs with relatively large and seemingly unfavorable tunneling distances.

293 s attack at the other pai-face results in an unfavorable "twist-boat" conformation.

294 c nature, which stabilizes the energetically unfavorable two-charge separated state by the formation

295 splitting reaction that is thermodynamically unfavorable under standard conditions, producing a nitri

296 ng metabolic alterations associated with the unfavorable VAT/(VAT + SAT) phenotype, we used the (2)H(

297 , postoperative hypotony was a predictor for unfavorable visual and anatomical outcomes.

298 55-2.97) in participants in the fourth (most unfavorable) vs first (most favorable) genetic score qua

299 mational entropy can range from favorable to unfavorable, which demonstrates the potential of this th

300 interactions are unfavorable, becoming more unfavorable with increasing alkylation.