ライフサイエンスコーパス: unfold

1 re isolated, a vast outbreak may nonetheless unfold.

2 ly over time, as external events continually unfold.

3 omething no one else knew and seeing a story unfold.

4 hielded or vaccinated as the global pandemic unfolds.

5 rates across countries and how transmission unfolds.

6 d from its Habc domain and its linker region unfolded.

7 y later when their professional careers had unfolded.

8 shifts in the occupied subspace as movement unfolded.

9 serve mental health complaints as the crisis unfolded.

10 and makes Red Broccoli resistant to thermal unfolding.

11 specific regions of the protein that undergo unfolding.

12 aged complex that is competent for substrate unfolding.

13 that is not accounted for by denaturation or unfolding.

14 rowding is able to partially rescue G4Q from unfolding.

15 t are resistant to both charge migration and unfolding.

16 globin, followed by cofactor loss and globin unfolding.

17 on had a destabilizing effect on the protein unfolding.

18 ic regions exposed to solution after protein unfolding.

19 ed alpha-syn destabilizes the G4Q leading to unfolding.

20 t of exchange behaviors: PhoA((350-471)), an unfolded 122-residue fragment; barstar, a fully folded r

21 ence are thought to depend on processes that unfold after events are initially encoded into memory.

22 Unfolding along this path is required for mtClpX to gate

23 ould also affect the proteasome's ability to unfold and degrade substrates.

24 ertain beta-strands in transthyretin tend to unfold and sample nonnative conformations and that the e

25 POT1 unfolded and bound to any conformational form of human t

26 structural information of myoglobin, for the unfolded and even for the molten globule states, models

27 agnetization transfers between water and the unfolded and folded states; cross-correlated relaxation

28 aryotic cells in response to accumulation of unfolded and misfolded proteins.

29 The dynamics of the acid unfolded and molten globule state are similar in the fra

30 tate (TS) located almost halfway between the unfolded and native states.

31 of almond milk proteins was assessed, as the unfolding and association of these proteins in response

32 alternative clipping pathway that precludes unfolding and degradation; the UBL degron favors degrada

33 ing affinity, monitoring protein folding and unfolding and determining hidden conformational changes

34 oteins have key functionalities encompassing unfolding and disassembly of such substrates in differen

35 ein stability is related to the ratio of the unfolding and folding rates, this increase completely ac

36 chemical prodrugs addresses issues with RNA unfolding and nanoparticle dissociation after high-densi

37 ime-resolved luminescence method for protein unfolding and PLI detection with nanomolar sensitivity.

38 equilibrium constants for both G-quadruplex unfolding and POT1 binding to the resultant single-stran

39 76% and 94% respectively), suggesting domain unfolding and preference for 'end-on' oriented binding,

40 nning calorimetry, enable studies on protein unfolding and protein-ligand interactions (PLI).

41 ichia coli ClpAP undergoing active substrate unfolding and proteolysis.

42 ulation studies of the temperature dependent unfolding and refolding of a titin immunoglobulin domain

43 c, energy-intensive mechanism to promote RNA unfolding and refolding, suggesting an evolutionary conv

44 he ClpA double-ring hexamer powers substrate unfolding and translocation into the ClpP proteolytic ch

45 enosine triphosphate (ATP)-fueled mechanical unfolding and translocation steps that lead to processiv

46 mplex is a conserved bacterial protease that unfolds and degrades proteins targeted for destruction.

47 imer dissociates into monomers, it partially unfolds and exhibits enhanced activity.

48 How this life cycle unfolds and how host and parasite interact remain largel

49 gen (PA) forms an oligomeric translocon that unfolds and translocates either its lethal factor (LF) o

50 od subdomains are stabilized by force during unfolding, and US confirmed these results.

51 ads to the generation of higher fractions of unfolded apo subunits and free hemin, which are known to

52 domain show pronounced differences in their unfolding behavior, underlining the fact that the choice

53 and found that they differ in stability and unfolding behavior.

54 ng transition suggests a classical two-state unfolding behavior.

55 along with the first transmembrane helix, we unfolded bR in the presence of its retinal.

56 f state of myosin II, for its activation and unfolding by phosphorylation, and for understanding the

57 n cbEGF domains uniquely orchestrate protein unfolding by showing that MFS disulfide bond mutations m

58 nvironments by shifting the onset of protein unfolding by ~100 MPa.

59 hort-degron protein substrates, we show that unfolding can occur directly from the initial closed-cha

60 First, Hsp33 binds unfolded chains, which suppresses aggregation between su

61 We find that rather than simply unfolding chromatin, histone hyperacetylation results in

62 source optics for improved collision induced unfolding (CIU) experiments and an electromagnetostatic

63 Ion mobility (IM)-based collision-induced unfolding (CIU) has gained increasing attention to probe

64 tive ion mobility (IM) and collision induced unfolding (CIU) mass spectrometry (MS).

65 -ion mobility (IM)-MS with collision-induced unfolding (CIU), chemical labeling using N-ethylmaleimid

66 differing in core properties: folded versus unfolded configurations in a protein molecular dynamics

67 s on beta-lactoglobulin melting temperature, unfolded conformation and subsequent intermolecular inte

68 pseudoknot and promotes a dynamic, partially unfolded conformation.

69 avirus 2 (SARS-CoV-2) has caused the rapidly unfolding coronavirus disease 2019 (COVID-19) pandemic(1

70 characterize certain folded sites over their unfolded counterparts-are considered to account for them

71 e not observed, we estimate that each global unfolding cycle consumes ~10 ATPs.

72 arlier findings that ~90% of global ribozyme unfolding cycles lead back to the kinetically preferred

73 ectional protein translocase that is able to unfold diverse substrates by processive threading throug

74 me oxidized in vivo through the mechanism of unfolded domain oxidation (UnDOx).

75 esidues leads to significant collapse of the unfolded ensemble of pertactin, a secreted autotransport

76 The chemical denaturant reduces the unfolding enthalpy DeltaH(cal) and lowers the midpoint t

77 ch partially compensates the endothermic mAb unfolding enthalpy.

78 hese interventions, based on modeling of the unfolding epidemic.

79 g theory for the quantitative description of unfolding events of large, therapeutic proteins, such as

80 Both unfolding experiments and independent small angle x-ray

81 DNA-based i-motifs unfold fast in response to small heats but do not fold b

82 drkN SH3, a protein domain whose folded and unfolded forms interchange rapidly and with temperature-

83 R17, a 13.3 kDa system possessing folded and unfolded forms under slow interconversion; and drkN SH3,

84 Unfolding free energy profiles determined by BXD suggest

85 es up to ~300 MPa: either a complete protein unfolding, from native dimers to Gaussian chains, or a p

86 force range relevant for protein folding and unfolding, from which single-molecule kinetic and thermo

87 ging and time-dependent chemical trapping of unfolded G4s in living cells reveal that G4s fluctuate b

88 recognize microRNAs (miRNAs) that populated unfolded hairpins.

89 rin protein POT1 (Protection of Telomeres 1) unfolds human telomeric G-quadruplex structures is not f

90 cleaved folded state is unstable and quickly unfolds if the RNA does not react.

91 ory specificity of mouse defensive behaviors unfold in a higher dimensional space, spanning multiple

92 ape children's beliefs and behaviors as they unfold in real world environments.

93 aturally decomposed into multiple tasks that unfold in sequence or in parallel.

94 This reveals a heightening of the barrier to unfolding in G37R by >5 kJ/mol(-1) over the other varian

95 ly toxic to myeloma cells by causing protein unfolding, increasing further the substrate load on prot

96 vidence that the hierarchy discovery process unfolds incrementally across trials.

97 Recently, unfolding intermediates separated by as few as two amino

98 ontrast to small single-domain proteins, mAb unfolding is a complex reaction that is analyzed with th

99 For the investigated mAb, unfolding is characterized by a cooperativity parameter

100 number of guanidineHCl molecules bound upon unfolding is deduced from the DSC thermograms.

101 twork of character interactions as the story unfolds, it is found that structural properties remain a

102 absence of ligand the riboswitch is largely unfolded, lacking the PK helix so that translation can b

103 ID-19) are being encountered as the pandemic unfolds, leading to non-chest CT scans that may uncover

104 evelopment of biotherapeutics, where protein unfolding leads to adverse properties, such as aggregati

105 res of heptameric PA channels with partially unfolded LF and EF at 4.6 and 3.1- angstrom resolution,

106 The guanidineHCl concentrations needed to unfold mAb at 25 degrees C are predicted to be 2-3 M for

107 ned, these results support a charge-directed unfolding mechanism for protein complexes.

108 We proposed a possible "refolding-after-unfolding" mechanism, as further supported by monitoring

109 epending on BLG concentration, two different unfolding mechanisms are observed in situ under pressure

110 Thus, it appears that as events unfold mentally, structures are dynamically reactivated

111 It has been thought that only unfolded monomers assemble into bipolar and side-polar (

112 G4 formation (folding), stabilization, and unfolding must be regulated to coordinate G4-mediated bi

113 Basophil activation by unfolded mutant Ara h 2 was low (median area under the c

114 The unfolded mutant lacking both types of epitopes displayed

115 ments also indicated that the charge at the "unfolding" N-terminus of ADH decreased at high in-source

116 During microbial infection, unfolded nascent proteins may exceed the folding capacit

117 providers might be content to let the events unfold naturally, whereas others may insist on intense f

118 Their unfolding occurs on the luminal side of the membrane by

119 sed excitability, which promotes accelerated unfolding of a neural 'script' for task execution, despi

120 The thermal unfolding of a recombinant monoclonal antibody IgG1 (mAb

121 -42) is electrostatically driven and induces unfolding of Abeta(M1-42).

122 In this report, a stepwise unfolding of bovine serum albumin (BSA) with guanidine h

123 BI prevents thermal unfolding of Broccoli at 37 degrees C, leading to more f

124 menon can be explained by the combination of unfolding of disordered domains and breaking of native c

125 olecular dynamics simulations the mechanical unfolding of dystrophin's spectrin repeat 1 and related

126 Local unfolding of either betaB-betaD or helix 2 can generate

127 the recognition, chaperone dissociation and unfolding of exported T3SS proteins.

128 l, we identified 31 intermediates during the unfolding of five helices of EF-cleaved bR.

129 sigma ~6 x 10(-5) and a Gibbs free energy of unfolding of g(nu) ~100 cal/mol per amino acid.

130 It further accelerates the unfolding of helices and a complete collapse of structur

131 the protein cavity, but only the fast local unfolding of helix 2 is relevant to the ligand entry pro

132 n of conserved cysteine residues and partial unfolding of its structure convert the heat shock protei

133 IM-MS platforms, allowing for comprehensive unfolding of large multiprotein complex ions as well as

134 ation of LPL, accomplished by catalyzing the unfolding of LPL, does not require the conversion of LPL

135 o 5D2-bound LPL counteracts ANGPTL4-mediated unfolding of LPL.

136 ined increasing attention to probe gas-phase unfolding of proteins and their noncovalent complexes, n

137 Such analyses revealed unfolding of proteins on the mineral surface and an incr

138 e the scope and limitations of S1-chaperoned unfolding of structured RNAs.

139 hniques and provide free energy profiles for unfolding of talin rod subdomains.

140 xtraction and that Hp binding prevents local unfolding of the Hb heme pocket, leaving IsdH unable to

141 gy barrier for unfolding, resulting in rapid unfolding of the protein.

142 molecular dynamics (MD) simulations to study unfolding of the talin rod.

143 Instead, we found that the unfolding of the target site structure plays a key role

144 ry complex as well as its ability to prevent unfolded OMP (uOMP) aggregation.

145 Together, the results suggest that unfolded OMP substrates bind in a cradle formed between

146 nother, forming dynamic representations that unfold on the underlying network.

147 ith: space-filling 'side-on' orientation and unfolding on CH(3) SAM; greater numbers of FN molecules

148 ures, has been proposed to cycle between an "unfolded"/"open" state that allows an NTP substrate to e

149 nonically, they act as "holdases" and buffer unfolded or misfolded proteins against aggregation in an

150 ress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticu

151 e proteins often result in gas-phase protein unfolding or loss of noncovalent interactions.

152 engue serotypes in Puerto Rico and a rapidly unfolding outbreak of plague in 2017 in Madagascar.

153 structural remodeling in peri-infarct cortex unfolded over the first 2 weeks after stroke, characteri

154 However, when an experience unfolds over time, humans tend to assign disproportionat

155 spatial attention as a dynamic process that unfolds over time.

156 ur alpha-helices of ACBP and showed that the unfolding pathway is marginally affected by the ligand.

157 Mg(2+)-RNA interactions that occur along an unfolding pathway of the Twister ribozyme.

158 e-profile analysis, to probe the folding and unfolding pathways of RNase H (RNH) nascent chains stall

159 Upon IdeS-digestion, the unfolding patterns of the F(ab')(2) and Fc domains were

160 motor of the cpSec1 translocon that inserts unfolded Plsp1 into the thylakoid.

161 strated that water can be a good solvent for unfolded polypeptide chains, even those with a hydrophob

162 The unfolding process does not require direct adsorption of

163 after a first, to our knowledge, successful unfolding process that represents a point of no return a

164 tide chain has a substantial impact on which unfolding properties are observed by single-molecule For

165 radation machines that use ATP hydrolysis to unfold protein substrates and translocate them through a

166 ng autophagy, leading to the accumulation of unfolded protein aggregates and dysfunctional mitochondr

167 MNRR1 in DW7 cells induces the mitochondrial unfolded protein response (UPR(mt)), autophagy, and mito

168 exposed to IR, to assess epithelial damage, unfolded protein response (UPR) activation, and inflamma

169 Meanwhile, UL148 activates the unfolded protein response (UPR) and causes large-scale r

170 The integrated unfolded protein response (UPR) and ER-associated degrad

171 lding capacity of the ER is regulated by the unfolded protein response (UPR) and ER-associated degrad

172 e folding capacity of the ER, activating the unfolded protein response (UPR) and restoring the ER to

173 ding networks associated with activating the unfolded protein response (UPR) and the proinflammatory

174 gly, we found a decoupling between different unfolded protein response (UPR) branches in stressed sen

175 pha regulatory subunit of PI3K modulates the unfolded protein response (UPR) by interacting with and

176 of primary CD34 cells, quantitative PCR for unfolded protein response (UPR) genes, and single-cell R

177 ) in the cytosol and nucleus, as well as the unfolded protein response (UPR) in the endoplasmic retic

178 The unfolded protein response (UPR) is a cellular homeostati

179 The unfolded protein response (UPR) is a conserved adaptive

180 uction of high mannose is dependent upon the unfolded protein response (UPR) pathway, a pathway previ

181 oxidative stress and aberrant activation of unfolded protein response (UPR) pathway, which was parti

182 The unfolded protein response (UPR) plays a central role in

183 reticulum (ER) stress and activation of the unfolded protein response (UPR) promote growth and invas

184 ng and molecular dynamics simulations, human unfolded protein response (UPR) RT(2) PCR profiler array

185 The unfolded protein response (UPR) senses defects in the en

186 3-19K glycoprotein specifically triggers the unfolded protein response (UPR) sensor IRE1alpha in the

187 nockdown in pancreatic cancer cells enhanced unfolded protein response (UPR) signaling and cell death

188 Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic

189 creased antibody synthesis by activating the unfolded protein response (UPR) under the control of the

190 tant is associated with the induction of the unfolded protein response (UPR), a common response to vi

191 ng protein glycosylation, causes a sustained Unfolded Protein Response (UPR), a significant attenuati

192 The unfolded protein response (UPR), an endoplasmic reticulu

193 an ER membrane-associated protein mediating unfolded protein response (UPR), is required for transdu

194 gnaling processes, collectively known as the unfolded protein response (UPR), which are designed to r

195 the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)-a signaling network that

196 butes to the activation of the mitochondrial unfolded protein response (UPR).

197 to cause ER stress, which then activates the unfolded protein response (UPR).

198 d activates a signaling network known as the unfolded protein response (UPR).

199 and refolding malformed proteins through the unfolded protein response (UPR).

200 ER calcium depletion robustly activates the unfolded protein response (UPR).

201 or extrinsic factors, can be resolved by the unfolded protein response (UPR).

202 epression by various stresses, including the unfolded protein response (UPR).

203 requires DRH-1 as well as the mitochondrial unfolded protein response (UPRmt).

204 reticulum (ER) stress proteins, and reduced unfolded protein response activation, while DN mutations

205 r mechanisms of tumor regression through the unfolded protein response and apoptosis.

206 B cells of the I-A(12%) mutant mouse express unfolded protein response and are extremely short lived.

207 phosphorylation likely leads to unregulated unfolded protein response and cell death.

208 the S.-japonicus-type phospholipids exhibits unfolded protein response and downregulates secretion.

209 -box binding protein 1 (XBP-1s), part of the unfolded protein response and expressed in developing ge

210 get engagement and reduced oxidative stress, unfolded protein response and fibrogenic signaling.

211 ga-3 fatty acid (omega-3)-mediated repair of unfolded protein response and here we show much broader

212 SINE-deleted cells exhibit an activated unfolded protein response and PKR and markedly increased

213 d over 2,800 genes, including players in the unfolded protein response and proinflammatory pathways a

214 , we show that an AS15 analogue triggers the unfolded protein response in glioblastoma cells.

215 Among the myriad molecules activated by unfolded protein response in I-A(12%) B cells, Xbp1s sin

216 derscore the importance of the mitochondrial unfolded protein response in neuroprotection against var

217 te disturbances in proteostasis, such as the unfolded protein response of the endoplasmic reticulum (

218 homeostasis by activating the PERK-dependent unfolded protein response pathway to consequently facili

219 lcium channel auxiliary subunit BARP and the unfolded protein response sensor IRE1alpha, that are req

220 beta4 surface expression while IRE1alpha, an unfolded protein response sensor, enhanced alpha6beta4 r

221 cells expressing IRE1beta have an attenuated unfolded protein response to ER stress.

222 gulated inhibitory (HRI) induced a cytosolic unfolded protein response to prevent aggregation of inna

223 doplasmic reticulum processes, including the unfolded protein response, a cellular stress response of

224 The importance of the mitochondrial unfolded protein response, an emerging pathway that alle

225 ng in endoplasmic reticulum (ER) stress, the unfolded protein response, and ultimately apoptotic cell

226 lational reprogramming, and induction of the unfolded protein response, consistent with loss of prote

227 pproach revealed that heat shock, unlike the unfolded protein response, leads to reduced spreading of

228 components (the ubiquitin-proteasome system, unfolded protein response, macroautophagy, mitophagy, an

229 te stress response such as the mitochondrial unfolded protein response, UPRMT.

230 lls with GRP78 overexpression via activating unfolded protein response-mediated apoptosis.

231 nstead retained the ER where it activates an unfolded protein response.

232 way, autophagy, proteasome function, and the unfolded protein response.

233 Case activity in these cells and induced the unfolded protein response.

234 induced XBP1 splicing, a key mediator of the unfolded protein response.

235 expected, as evidenced by activation of the unfolded protein response.

236 me 1 (IRE1) is an essential component of the Unfolded Protein Response.

237 TKI resistance via induction of Jun and the unfolded protein response.

238 4E-BP1 activation promoted the mitochondrial unfolded protein response.

239 P or deletion of Ryr2 equivalently inhibited unfolded protein response/ER stress, activation of the C

240 ignaling pathway regulates lipid metabolism, unfolded protein responses, secretion of extracellular m

241 The UPR is triggered by unfolded protein stress and leads to up-regulation of ce

242 defect is the uncontrolled initiation of the unfolded protein stress response, with single-cell analy

243 It is hypothesised that the partially unfolded protein structures have a lower number of hydro

244 strongly up-regulated genes are involved in unfolded-protein stress response, and cells exposed to m

245 a highly active chaperone holdase that binds unfolded proteins and prevents their aggregation.

246 We show how the peak shapes of folded and unfolded proteins are preserved under added salt (0-140

247 Accumulation of unfolded proteins in the endoplasmic reticulum (ER) caus

248 Excess unfolded proteins in the ER lumen induce dimerization an

249 Upon sensing an accumulation of unfolded proteins in the ER lumen, IRE1 activates its cy

250 The enthalpy of unfolding provides the number of amino acid residues nu

251 d that ribosome-stalled RNH has an increased unfolding rate compared with free RNH.

252 The results indicate that a folding-unfolding reaction of a specialized temperature-sensitiv

253 increases the activation free energy for the unfolding reaction of ACBP without affecting the positio

254 ich POT1 binding is coupled to an obligatory unfolding reaction, is the most plausible mechanism.

255 amino acid residues nu participating in the unfolding reaction.

256 few as 10 tandem hairpins displayed ensemble unfolding/refolding transitions, which were exploited to

257 Backbone HDX is mediated by opening/closing (unfolding/refolding) fluctuations.

258 nabled monitoring of charge migration to the unfolded regions.

259 ts as an axonal tension buffer by reversibly unfolding repeat domains of the spectrin tetramers to re

260 the propensity for Coulombic repulsions and unfolding/restructuring, helping to preserve the native-

261 to a lowering of the free-energy barrier for unfolding, resulting in rapid unfolding of the protein.

262 creating a highly charged protein which both unfolds reversibly at low ionic strength and undergoes t

263 al predictions optimize our interaction with unfolding sensory events.SIGNIFICANCE STATEMENT Temporal

264 the linguistic information contained in the unfolding sentences modulates brain activity in a word-s

265 The unfolding signatures of both domains were allowed to cor

266 re the diagnostic domain to provide specific unfolding signatures to differentiate IgG subclasses and

267 and extrapolating transition rates from the unfolding simulations to lower, physiologically-reasonab

268 ECD fragments indicated unfolding started at the N-terminus, and the charge stat

269 ve state, observable intermediate state, and unfolded state for ETR-3 RRM-3, which has canonical RRM

270 The long lifetime, ~10 s, of the unfolded state presents ample opportunities for the poly

271 < 10 pN, titin domains are recruited to the unfolded state, and produce 41.5 zJ mechanical work duri

272 ssitate that water is a poor solvent for its unfolded state.

273 wo minor native-like states, and two locally unfolded states in aqueous solution.

274 reveal that G4s fluctuate between folded and unfolded states.

275 hosphorylated by various kinases because the unfolded structure of Tau makes them accessible.

276 period" largely determines how the situation unfolds subsequently.

277 Difficult-to-unfold substrates are released and re-engaged multiple t

278 gron favors degradation of even difficult-to-unfold substrates, whereas the Ub(4) degron favors clipp

279 c unfoldase, our results suggest that it may unfold the Cse4(CENP-A) histone and hand it over to Scm3

280 The ability of S1 to unfold the RNA is inversely correlated with the structur

281 AAA+ ATPase family function as hexamers that unfold their protein substrates.

282 more ordered and that the energy required to unfold these complexes increases as the number of coordi

283 as a G-quadruplex-unwinding helicase, which unfolds these stable secondary structures to regulate LA

284 h allow us to visualize how these migrations unfolded through time and space.

285 time was 5.9 +/- 1.1 minutes; and mean graft unfolding time was 2.9 +/- 0.9 minutes.

286 outcome measures were graft preparation and unfolding times, best spectacle-corrected visual acuity

287 as can cause structural changes ranging from unfolding to subunit dissociation.

288 The resulting zigzag unfolding trajectories occupied 40% more states per traj

289 challenging, in part because any individual unfolding trajectory only occupies a subset of the total

290 G37R, which proceeded only through the first unfolding transition and displayed a much higher abundan

291 pment of the interdomain distance during the unfolding transition suggests a classical two-state unfo

292 piconewtons of mechanical force to actively unfold translocating proteins, comparable to cellular un

293 hat is inherent to Cdc48, which specifically unfolds ubiquitylated Mcm7 and thereby disassembles CMG.

294 Surprisingly, the domain remains unfolded until it is fully synthesized, without collapsi

295 Ps across all kingdoms of life may partially unfold upon dissociation.

296 secondary structures that resist mechanical unfolding while minimizing the amount of computational r

297 e concentration of FA and the free energy of unfolding with a slope of m (FA+pH) (the combined contri

298 tive dimers to Gaussian chains, or a partial unfolding with oligomerization in tetramers mediated by

299 However, "refolding-after-unfolding" with increasing in-source activation was not

300 d that POT1 binding is coupled to quadruplex unfolding, with a final complex with a stoichiometry of