ライフサイエンスコーパス: unfolded

1 y later when their professional careers had unfolded.

2 shifts in the occupied subspace as movement unfolded.

3 serve mental health complaints as the crisis unfolded.

4 d from its Habc domain and its linker region unfolded.

5 2.5 angstrom), but they are far apart in the unfolded 1,4-isomer (H...H distance ~ 7 angstrom).

6 t of exchange behaviors: PhoA((350-471)), an unfolded 122-residue fragment; barstar, a fully folded r

7 eractions are involved in recognition of the unfolded A2 domain.

8 The bound guanidineHCl-to-unfolded amino acid ratio is 0.79 for the pretransition

9 POT1 unfolded and bound to any conformational form of human t

10 actors that cause different substrates to be unfolded and degraded to different extents are still poo

11 structural information of myoglobin, for the unfolded and even for the molten globule states, models

12 The unfolded and flattened surface comprised a narrow strip

13 agnetization transfers between water and the unfolded and folded states; cross-correlated relaxation

14 otein activated at the matrix remains mostly unfolded and is transported back to the IMS to integrate

15 aryotic cells in response to accumulation of unfolded and misfolded proteins.

16 The dynamics of the acid unfolded and molten globule state are similar in the fra

17 tate (TS) located almost halfway between the unfolded and native states.

18 of secondary structure elements in the acid unfolded and presence of alpha-helices in the molten glo

19 arly in a transition path, N(TAIL) typically unfolded and then refolded after additional intermolecul

20 ntrol that regulate turnover of short-lived, unfolded, and misfolded proteins.

21 ntaneous A2 domain state as either folded or unfolded, and were directly taken from coarse-grained MD

22 Accumulation of unfolded antibody chains in the ER triggers ER stress th

23 dependent pathway involved in degradation of unfolded antibody HC.

24 ads to the generation of higher fractions of unfolded apo subunits and free hemin, which are known to

25 es to produce populations of both folded and unfolded apoprotein.

26 in that harbors the vinculin-binding site is unfolded at ~6 pN; and 3) unfolding of the M1 domain is

27 dimers, tail-folded antiparallel tetramers, unfolded bipolar tetramers, and small filaments.

28 along with the first transmembrane helix, we unfolded bR in the presence of its retinal.

29 r of drkN SH3, for which HyperW enhanced the unfolded but, surprisingly, enhanced even more certain f

30 nd chemical denaturation: whereas TriEst was unfolded by heating ( T(m) ~ 75 degrees C) or denatured

31 First, Hsp33 binds unfolded chains, which suppresses aggregation between su

32 ucture of mTXNPx in complex with a thermally unfolded client protein, and revealed that the flexible

33 rcharged [M + zH] (z+) ions are formed under unfolded conditions remains unclear.

34 differing in core properties: folded versus unfolded configurations in a protein molecular dynamics

35 s on beta-lactoglobulin melting temperature, unfolded conformation and subsequent intermolecular inte

36 pseudoknot and promotes a dynamic, partially unfolded conformation.

37 iple folding pathways connecting a myriad of unfolded conformations and a well-defined folded state.

38 Our data show that fluctuations between unfolded conformations are slow, which enables the exper

39 bition by interacting not with the monomeric unfolded conformations of the amyloid-beta symbol (Abeta

40 In this case, rapid fluctuations between unfolded conformations result in apparent two-state beha

41 regation appears to originate from partially unfolded conformations that are sampled through stochast

42 characterize certain folded sites over their unfolded counterparts-are considered to account for them

43 me oxidized in vivo through the mechanism of unfolded domain oxidation (UnDOx).

44 As a consequence, unfolded domains accumulate during synthesis, leading to

45 s nonconstitutive folding and aggregation of unfolded domains.

46 esidues leads to significant collapse of the unfolded ensemble of pertactin, a secreted autotransport

47 ially folded (molten globule) and completely unfolded, following two different unfolding paths: using

48 rposition of >=100-fold enhancements for its unfolded form, coexisting with more modest enhancements

49 drkN SH3, a protein domain whose folded and unfolded forms interchange rapidly and with temperature-

50 R17, a 13.3 kDa system possessing folded and unfolded forms under slow interconversion; and drkN SH3,

51 ging and time-dependent chemical trapping of unfolded G4s in living cells reveal that G4s fluctuate b

52 recognize microRNAs (miRNAs) that populated unfolded hairpins.

53 neoplasm characterized by the production of unfolded immunoglobulins, which cause endoplasmic reticu

54 how the epidemic and public health response unfolded in Australia up to 13 April.

55 Proteins that are unfolded in solution produce higher charge states during

56 The unfolded, inactive peptide is dephosphorylated, shifting

57 monomeric species, formation of a partially unfolded intermediate in the dimer to tetramer size rang

58 ion has been shown to proceed from partially unfolded intermediates in these proteins; their extreme

59 solvents on the equilibrium of folded versus unfolded isomers.

60 absence of ligand the riboswitch is largely unfolded, lacking the PK helix so that translation can b

61 res of heptameric PA channels with partially unfolded LF and EF at 4.6 and 3.1- angstrom resolution,

62 We also evaluated the influence of the unfolded model in the stability calculations using incre

63 eventing hemin disassociation from partially unfolded, molten globular species during early disassemb

64 s a structural transition from predominately unfolded monomer at low concentrations to an alpha-helic

65 It has been thought that only unfolded monomers assemble into bipolar and side-polar (

66 in (TTR) involves self-assembly of partially unfolded monomers.

67 Upon release from polysomes, unfolded mRNAs outcompete G3BP auto-inhibitory interacti

68 Importantly, the unfolded MSD can refold with or without applied forces.

69 Basophil activation by unfolded mutant Ara h 2 was low (median area under the c

70 The unfolded mutant lacking both types of epitopes displayed

71 Unfolded mutants without conformational epitopes did not

72 During microbial infection, unfolded nascent proteins may exceed the folding capacit

73 The resulting compaction can bias unfolded nucleic acids towards folding, resulting in fas

74 ry complex as well as its ability to prevent unfolded OMP (uOMP) aggregation.

75 Together, the results suggest that unfolded OMP substrates bind in a cradle formed between

76 ures, has been proposed to cycle between an "unfolded"/"open" state that allows an NTP substrate to e

77 nonically, they act as "holdases" and buffer unfolded or misfolded proteins against aggregation in an

78 ress induced by the abnormal accumulation of unfolded or misfolded proteins at the endoplasmic reticu

79 productivity and often increase the load of unfolded or misfolded proteins in the endoplasmic reticu

80 structural remodeling in peri-infarct cortex unfolded over the first 2 weeks after stroke, characteri

81 near discriminant analysis, and discriminant unfolded partial least-squares.

82 motor of the cpSec1 translocon that inserts unfolded Plsp1 into the thylakoid.

83 providing a unified picture of the nature of unfolded polypeptide chains in the absence of denaturant

84 strated that water can be a good solvent for unfolded polypeptide chains, even those with a hydrophob

85 ng autophagy, leading to the accumulation of unfolded protein aggregates and dysfunctional mitochondr

86 s-including extracellular matrix regulation, unfolded protein binding, mitochondrial function, and in

87 a dual-color imaging strategy to distinguish unfolded protein oligomers from insoluble aggregates in

88 IF2alpha, and HSPB8 define a novel cytosolic unfolded protein response (cUPR) essential for optimal i

89 M1 deficiency strongly induced mitochondrial unfolded protein response (UPR(mt)) and enhanced mitocho

90 The mitochondrial unfolded protein response (UPR(mt)) is a mitochondrial-t

91 MNRR1 in DW7 cells induces the mitochondrial unfolded protein response (UPR(mt)), autophagy, and mito

92 exposed to IR, to assess epithelial damage, unfolded protein response (UPR) activation, and inflamma

93 action, ERK1/2 and CREB phosphorylation, and unfolded protein response (UPR) activation.

94 Meanwhile, UL148 activates the unfolded protein response (UPR) and causes large-scale r

95 Previous work showed involvement of unfolded protein response (UPR) and endoplasmic reticulu

96 ignancies exhibit dramatic activation of the unfolded protein response (UPR) and ER stress response v

97 The integrated unfolded protein response (UPR) and ER-associated degrad

98 lding capacity of the ER is regulated by the unfolded protein response (UPR) and ER-associated degrad

99 e folding capacity of the ER, activating the unfolded protein response (UPR) and restoring the ER to

100 These comprise, in particular, the unfolded protein response (UPR) and the DNA damage respo

101 The unfolded protein response (UPR) and the heat shock respo

102 ding networks associated with activating the unfolded protein response (UPR) and the proinflammatory

103 gly, we found a decoupling between different unfolded protein response (UPR) branches in stressed sen

104 ence of galactose, lithium ions activate the unfolded protein response (UPR) by inhibiting phosphoglu

105 pha regulatory subunit of PI3K modulates the unfolded protein response (UPR) by interacting with and

106 se RNF5 exhibit attenuated activation of the unfolded protein response (UPR) components, which coinci

107 f endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) consistent with elevated

108 rmacologic activation of the ATF6 arm of the unfolded protein response (UPR) during reperfusion, a ty

109 sing an engineered sensor that activates the unfolded protein response (UPR) exclusively when normal

110 of primary CD34 cells, quantitative PCR for unfolded protein response (UPR) genes, and single-cell R

111 The unfolded protein response (UPR) has been shown to be act

112 ) in the cytosol and nucleus, as well as the unfolded protein response (UPR) in the endoplasmic retic

113 kine-exposed beta-cells revealed an adaptive unfolded protein response (UPR) including a marked immun

114 The unfolded protein response (UPR) is a cellular homeostati

115 The unfolded protein response (UPR) is a conserved adaptive

116 ns, an adaptive signaling network termed the unfolded protein response (UPR) is activated.

117 The unfolded protein response (UPR) is emerging as the possi

118 Unfolded protein response (UPR) of the endoplasmic retic

119 cting endoplasmic reticulum (ER) stress, the unfolded protein response (UPR) orchestrates adaptive ce

120 uction of high mannose is dependent upon the unfolded protein response (UPR) pathway, a pathway previ

121 oxidative stress and aberrant activation of unfolded protein response (UPR) pathway, which was parti

122 ers of endoplasmic reticulum (ER) stress and unfolded protein response (UPR) pathways are increased i

123 The unfolded protein response (UPR) plays a central role in

124 reticulum (ER) stress and activation of the unfolded protein response (UPR) promote growth and invas

125 The PERK arm of the unfolded protein response (UPR) regulates cellular prote

126 he induction of apoptosis by an unresolvable unfolded protein response (UPR) represents a potential n

127 ng and molecular dynamics simulations, human unfolded protein response (UPR) RT(2) PCR profiler array

128 The unfolded protein response (UPR) senses defects in the en

129 3-19K glycoprotein specifically triggers the unfolded protein response (UPR) sensor IRE1alpha in the

130 nockdown in pancreatic cancer cells enhanced unfolded protein response (UPR) signaling and cell death

131 Cancer cells exploit the unfolded protein response (UPR) to mitigate endoplasmic

132 creased antibody synthesis by activating the unfolded protein response (UPR) under the control of the

133 hock response - indicating activation of the unfolded protein response (UPR) with downstream inflamma

134 tant is associated with the induction of the unfolded protein response (UPR), a common response to vi

135 tion, known as ER stress, is buffered by the unfolded protein response (UPR), a set of signaling path

136 proteostasis surveillance is mediated by the unfolded protein response (UPR), a signal transduction p

137 ied the improved workflow to proteins of the unfolded protein response (UPR), a signaling pathway of

138 ng protein glycosylation, causes a sustained Unfolded Protein Response (UPR), a significant attenuati

139 The unfolded protein response (UPR), an endoplasmic reticulu

140 placenta is susceptible to activation of the unfolded protein response (UPR), and we hypothesized thi

141 ion of misfolded proteins, activation of the unfolded protein response (UPR), decreased protein synth

142 Master regulators of the unfolded protein response (UPR), IRE1alpha and PERK, pro

143 an ER membrane-associated protein mediating unfolded protein response (UPR), is required for transdu

144 species (mtROS) production and, in turn, the unfolded protein response (UPR), leading to a distinct t

145 s induce chronic activation of ER stress and unfolded protein response (UPR), leading to T cell death

146 Chronic activation of the unfolded protein response (UPR), notably the branch comp

147 Here, we show that activation of the unfolded protein response (UPR), specifically phosphoryl

148 asmic reticulum stress and activation of the unfolded protein response (UPR), triggering death of neu

149 argets various cell processes, including the unfolded protein response (UPR), which acts to attenuate

150 gnaling processes, collectively known as the unfolded protein response (UPR), which are designed to r

151 the endoplasmic reticulum (ER) activate the unfolded protein response (UPR), which enhances protein

152 the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)-a signaling network that

153 and refolding malformed proteins through the unfolded protein response (UPR).

154 and bZIP60 but not bZIP17 and bZIP28 in the unfolded protein response (UPR).

155 ers a dynamic signaling pathway known as the unfolded protein response (UPR).

156 tivation of a signaling network known as the unfolded protein response (UPR).

157 t as primary sensor in the activation of the unfolded protein response (UPR).

158 n of ER stress coping responses, such as the unfolded protein response (UPR).

159 ER calcium depletion robustly activates the unfolded protein response (UPR).

160 or extrinsic factors, can be resolved by the unfolded protein response (UPR).

161 epression by various stresses, including the unfolded protein response (UPR).

162 butes to the activation of the mitochondrial unfolded protein response (UPR).

163 to cause ER stress, which then activates the unfolded protein response (UPR).

164 d activates a signaling network known as the unfolded protein response (UPR).

165 nstrated that CXL146 treatment activated the unfolded protein response (UPR); as evidenced by the act

166 requires DRH-1 as well as the mitochondrial unfolded protein response (UPRmt).

167 reticulum (ER) stress proteins, and reduced unfolded protein response activation, while DN mutations

168 r mechanisms of tumor regression through the unfolded protein response and apoptosis.

169 B cells of the I-A(12%) mutant mouse express unfolded protein response and are extremely short lived.

170 respond to OGT inhibition by activating the unfolded protein response and by significantly increasin

171 phosphorylation likely leads to unregulated unfolded protein response and cell death.

172 ex, and showed that these are related to the unfolded protein response and changes.

173 on of two PAWHs constitutively activates the unfolded protein response and compromises stress toleran

174 the S.-japonicus-type phospholipids exhibits unfolded protein response and downregulates secretion.

175 of beta-gal, resulting in activation of the unfolded protein response and endoplasmic reticulum stre

176 -box binding protein 1 (XBP-1s), part of the unfolded protein response and expressed in developing ge

177 get engagement and reduced oxidative stress, unfolded protein response and fibrogenic signaling.

178 ga-3 fatty acid (omega-3)-mediated repair of unfolded protein response and here we show much broader

179 activating tumor-promoting ER stress-induced unfolded protein response and inflammation.

180 SINE-deleted cells exhibit an activated unfolded protein response and PKR and markedly increased

181 d over 2,800 genes, including players in the unfolded protein response and proinflammatory pathways a

182 vation can robustly induce the mitochondrial unfolded protein response and thus could be an appealing

183 NMD-regulated link between activation of the unfolded protein response and transcriptional activation

184 contrast, glucose starvation does not cause unfolded protein response and, in normoxic conditions, o

185 ick-borne encephalitis viruses, activate the unfolded protein response before transcription of interf

186 roliferation via both JNK activation and the unfolded protein response caused by ER stress.

187 ion required activation of the mitochondrial unfolded protein response for neuroprotection against ro

188 enhanced expression of canonic mitochondrial unfolded protein response genes.

189 Moreover, both drugs also inhibited the unfolded protein response in cells that expressed a nonp

190 , we show that an AS15 analogue triggers the unfolded protein response in glioblastoma cells.

191 Among the myriad molecules activated by unfolded protein response in I-A(12%) B cells, Xbp1s sin

192 e 1alpha (IRE1alpha), a key component of the unfolded protein response in mammalian cells and a poten

193 derscore the importance of the mitochondrial unfolded protein response in neuroprotection against var

194 In turn, this forestalls activation of the unfolded protein response in order for circadian rhythms

195 te disturbances in proteostasis, such as the unfolded protein response of the endoplasmic reticulum (

196 ting mucin trafficking, thereby inducing the unfolded protein response pathway (UPR) and apoptosis.

197 homeostasis by activating the PERK-dependent unfolded protein response pathway to consequently facili

198 ction between age, APOE genotype, and sex on unfolded protein response pathway.

199 wever, 2-DG exerts these effects by inducing unfolded protein response rather than by inhibiting glyc

200 olding in the heart and thereby activates an unfolded protein response sensor and effector, activated

201 lcium channel auxiliary subunit BARP and the unfolded protein response sensor IRE1alpha, that are req

202 beta4 surface expression while IRE1alpha, an unfolded protein response sensor, enhanced alpha6beta4 r

203 show that the unfolded protein response sensor, PERK, enhances MDSC-me

204 that HRI contributes to a general cytosolic unfolded protein response that could be leveraged to bol

205 this stress, cells activate a pathway called unfolded protein response that functions to maintain end

206 enz protect cells from a tunicamycin-induced unfolded protein response to a similar degree.

207 cells expressing IRE1beta have an attenuated unfolded protein response to ER stress.

208 gulated inhibitory (HRI) induced a cytosolic unfolded protein response to prevent aggregation of inna

209 we identify the selective activation of the unfolded protein response transducer IRE1alpha under gen

210 tion is required for ER-phagy to repress the unfolded protein response via IRE1alpha.

211 doplasmic reticulum processes, including the unfolded protein response, a cellular stress response of

212 during biosynthesis in the ER activates the unfolded protein response, a multiarmed program that enh

213 The importance of the mitochondrial unfolded protein response, an emerging pathway that alle

214 ing proteins that comprise the mitochondrial unfolded protein response, and noted 4E-BP1 overexpressi

215 ng in endoplasmic reticulum (ER) stress, the unfolded protein response, and ultimately apoptotic cell

216 lational reprogramming, and induction of the unfolded protein response, consistent with loss of prote

217 ochondrial translation and the mitochondrial unfolded protein response, glycolysis, and the mitogen-a

218 pproach revealed that heat shock, unlike the unfolded protein response, leads to reduced spreading of

219 dative phosphorylation and activation of the unfolded protein response, linking the high-fat Western

220 components (the ubiquitin-proteasome system, unfolded protein response, macroautophagy, mitophagy, an

221 6) that otherwise elicited ER stress and the unfolded protein response, thereby critically reducing m

222 te stress response such as the mitochondrial unfolded protein response, UPRMT.

223 We find that P0Q215X does not elicit an unfolded protein response, which is a key mechanism for

224 lls with GRP78 overexpression via activating unfolded protein response-mediated apoptosis.

225 Case activity in these cells and induced the unfolded protein response.

226 induced XBP1 splicing, a key mediator of the unfolded protein response.

227 expected, as evidenced by activation of the unfolded protein response.

228 me 1 (IRE1) is an essential component of the Unfolded Protein Response.

229 TKI resistance via induction of Jun and the unfolded protein response.

230 4E-BP1 activation promoted the mitochondrial unfolded protein response.

231 of eIF2alpha, a major defensive step of the unfolded protein response.

232 ation via mechanisms outside its role in the unfolded protein response.

233 iculum kinase (PERK), a key component of the unfolded protein response.

234 n metabolic and oxidation processes, and the unfolded protein response.

235 most evolutionarily conserved branch of the unfolded protein response.

236 several genetic rescue interventions and the unfolded protein response.

237 transcription factor, a critical part of the unfolded protein response.

238 otif enhances colon epithelial repair via an unfolded protein response.

239 quitylated proteins and the induction of the unfolded protein response.

240 in the ER by initiating the widely conserved unfolded protein response.

241 nstead retained the ER where it activates an unfolded protein response.

242 way, autophagy, proteasome function, and the unfolded protein response.

243 P or deletion of Ryr2 equivalently inhibited unfolded protein response/ER stress, activation of the C

244 ve been implicated in key processes like the unfolded protein response; however, they have not been s

245 ses previously implicated in DILI, including unfolded protein responses and oxidative stress.

246 ignaling pathway regulates lipid metabolism, unfolded protein responses, secretion of extracellular m

247 ocesses such as those required for auxin and unfolded protein responses, signaling, and cell wall bio

248 enhancements were >=300x, as expected for an unfolded protein sequence.

249 ention is required to characterize partially unfolded protein states and to gain more insight into th

250 The UPR is triggered by unfolded protein stress and leads to up-regulation of ce

251 defect is the uncontrolled initiation of the unfolded protein stress response, with single-cell analy

252 without affecting the endoplasmic reticulum unfolded protein stress-induced ISR, mediated by the rel

253 It is hypothesised that the partially unfolded protein structures have a lower number of hydro

254 Ubl-containing proteins (if present with an unfolded protein) increased proteasomal adenosine 5'-tri

255 tolerance following phagocytosis through an unfolded protein/endoplasmic reticulum stress response p

256 strongly up-regulated genes are involved in unfolded-protein stress response, and cells exposed to m

257 by a feedback inhibition mechanism involving unfolded proteins and folding intermediates when their l

258 ink between stresses such as accumulation of unfolded proteins and modulation of autophagy, which rem

259 a highly active chaperone holdase that binds unfolded proteins and prevents their aggregation.

260 We show how the peak shapes of folded and unfolded proteins are preserved under added salt (0-140

261 a stress response mechanism to clear out the unfolded proteins by either facilitating their re-foldin

262 olding systems, we reveal the segregation of unfolded proteins from folded proteins in the Golgi.

263 Accumulation of unfolded proteins in the endoplasmic reticulum (ER) caus

264 Accumulation of unfolded proteins in the endoplasmic reticulum (ER) init

265 Excess unfolded proteins in the ER lumen induce dimerization an

266 Upon sensing an accumulation of unfolded proteins in the ER lumen, IRE1 activates its cy

267 Our results imply that supercharging of unfolded proteins is caused by residual sulfolane that s

268 "CEM supercharging model" proposed here for unfolded proteins is distinct from the charge trapping m

269 Unfolded proteins likely follow the chain ejection model

270 re committed to lysosomal degradation, while unfolded proteins localize to the endoplasmic reticulum

271 The Sec channel enables passage of unfolded proteins through the bacterial plasma membrane,

272 In solution, unfolded proteins typically find this native structure t

273 osylation of S/T-rich protein substrates and unfolded proteins.

274 We show that the unfolded regions face the air-water interface.

275 nabled monitoring of charge migration to the unfolded regions.

276 ve state, observable intermediate state, and unfolded state for ETR-3 RRM-3, which has canonical RRM

277 rienced by C. elegans, the population of the unfolded state of the TZF domain of MEX-5 varies.

278 The long lifetime, ~10 s, of the unfolded state presents ample opportunities for the poly

279 < 10 pN, titin domains are recruited to the unfolded state, and produce 41.5 zJ mechanical work duri

280 d state and a knowledge-based energy for the unfolded state.

281 substrate segments cross the membrane in an unfolded state.

282 ssitate that water is a poor solvent for its unfolded state.

283 pulled together), a balance that stabilizes unfolded states and facilitates the folding of Twister,

284 y profiles reveal stabilization of partially unfolded states by Mg(2+), as observed in unfolding expe

285 wo minor native-like states, and two locally unfolded states in aqueous solution.

286 ns of the ion with compact intermediates and unfolded states of RNA is challenging to investigate, an

287 imply that water is a "poor" solvent for the unfolded states of these same proteins?

288 pendent NMR signals from both the folded and unfolded states revealed the population of at least one

289 the intrinsic fluctuations of the folded and unfolded states, which was measured by single-molecule (

290 ased energy function for both the folded and unfolded states.

291 reveal that G4s fluctuate between folded and unfolded states.

292 Moreover, the partially unfolded structure of alpha-lactalbumin in the nanoprobe

293 hosphorylated by various kinases because the unfolded structure of Tau makes them accessible.

294 hypothesised that denatured proteins with an unfolded structure, would have greater interaction with

295 In addition, the unfolded structures originating from mechanical pulling

296 teracts with the heads (10S) and one with an unfolded tail (6S).

297 of contour length changes as the structures unfolded through intermediate states was compared to the

298 h allow us to visualize how these migrations unfolded through time and space.

299 The unfolded ubiquitin molecule binds to Npl4 and projects i

300 Surprisingly, the domain remains unfolded until it is fully synthesized, without collapsi