ライフサイエンスコーパス: unintended

1 and also on the actual harm caused-even when unintended.

2 actor's harm was intentional; when harm was unintended, a temporoparietal-medial-prefrontal circuit

3 he immune system are critical for preventing unintended activation of immune cells.

4 Failure to prevent this unintended activation raises the risk of developing exag

5 measure must have little chance of inducing unintended adverse consequences.

6 r treatment period, but there were also some unintended adverse consequences.

7 mperfect as it lacks specificity and imposes unintended adverse effects such as opportunistic infecti

8 Because antimicrobials can have unintended adverse health and environmental impacts, the

9 t as an ingredient, this is not the case for unintended allergen presence (UAP).

10 population restricts the advice on levels of unintended allergenic foods which should trigger precaut

11 is used to warn consumers of the presence of unintended allergens, but the lack of agreed allergen th

12 Such unintended alterations can confound interpretation of ex

13 priate molecular screening methods to detect unintended alterations following genome engineering.

14 I also cover unintended and adverse consequences for the field, inclu

15 This research shows the potential for unintended and negative consequences of climate change m

16 rtunately, this success has been tempered by unintended and often devastating cardiac complications a

17 re prone to error and can impart images with unintended attributes that might be misconstrued as belo

18 to the pleotropic properties of macrolides, unintended bacteriological consequences such as augmente

19 nique hepatic immune physiology and provides unintended benefits for allografts by modulating various

20 For all other scenarios, an unintended bias is introduced with respect to the primar

21 etrospective epidemiologic studies; however, unintended biases may exist when analysis is performed b

22 nets of nucleic acid chemistry; however, the unintended binding of closely related sequences limits t

23 ake and payload encapsulation, and may cause unintended biological responses such as immune system ac

24 of toxic catalysts, and side reactions with unintended biomolecules.

25 l activity is a common side effect caused by unintended block of the promiscuous drug target human et

26 n using our arms to interact with the world, unintended body motion can introduce movement error.

27 n using our arms to interact with the world, unintended body motion can introduce movement error.

28 alance control system attempting to minimise unintended body motion, while the later response arises

29 An upgrade with ozonation may lead to unintended bromate formation in bromide-containing waste

30 The unintended but potentially profound consequences of infr

31 produced by these host-adapted species is an unintended by product of the inflammation but host damag

32 uggested that those compounds were formed as unintended byproducts.

33 eptides are highly potent and therefore, any unintended change in the microsphere release profile may

34 ly limited species and genotypes, and causes unintended changes to the genome and epigenome.

35 mic-scale defects, structural distortion and unintended chemical functionalization, leading to unpred

36 ant association between the intervention and unintended clinical consequences, with the exception of

37 were firmly established appears to have had unintended clinical consequences.

38 We aimed to evaluate possible unintended clinical outcomes related to this QP.

39 e minimal CRY2 homo-oligomerization to avoid unintended complications, while those utilizing CRY2-CRY

40 ng has been used to assess the potential for unintended composition changes in potato (Solanum tubero

41 an be a primary goal (cow dung mixing) or an unintended consequence (anaerobic digesters).

42 An unintended consequence of DDR attenuation during infecti

43 An unintended consequence of global change is an increase i

44 ply modern contraceptives, it could have the unintended consequence of increasing abortion rates.

45 Whether readmission reductions have had the unintended consequence of increasing mortality after hos

46 ates of Medicaid have raised concerns on the unintended consequence of lower utilization of life-savi

47 The focus on passing the TCLP has the unintended consequence of making recycling more difficul

48 An unintended consequence of observation is that it may inc

49 d coronary artery bypass graft (CABG) are an unintended consequence of public reporting of cardiogeni

50 and export of nitrogen from large lakes, an unintended consequence of single-element management that

51 This finding indicates an unfortunate and unintended consequence of the gendered naming of hurrica

52 This unintended consequence of the new regulations has meant

53 ductions in biennial mammography might be an unintended consequence of the updated guidelines.

54 The unintended consequence of this functional program is hig

55 tionships with peers and staff largely as an unintended consequence of trying to have a life in the n

56 assumption that head movements are simply an unintended consequence of undulation, existing only beca

57 The unintended consequence resulted from macrophage-like fet

58 world, increases in wealth have produced an unintended consequence: a rising sense of time scarcity.

59 results can be used to anticipate potential unintended consequences and develop design pathways that

60 These efforts could have unintended consequences and increase overall surgical ep

61 s, mandated treatments in sepsis may lead to unintended consequences as the standard of care in sepsi

62 taldehyde, however this approach can lead to unintended consequences due to the generation of reactiv

63 rationale for targeting these cytokines, the unintended consequences for host defense and tumor surve

64 her factors such as processed food, have had unintended consequences for the human microbial ecosyste

65 bility across organisms and antibiotics, and unintended consequences from compensatory prescribing ma

66 This uncontrolled reaction can lead to unintended consequences including off-target editing and

67 Thematic analysis identified unintended consequences of 12 h shifts as these patterns

68 ght some of the problems, contradictions and unintended consequences of a divergence between patient

69 There are benefits but also unintended consequences of antimicrobial and infection p

70 do so to consider how they can mitigate the unintended consequences of conference and travel cancell

71 gs to Medicare and highlighting the possible unintended consequences of coverage decisions.

72 negative effects of alert fatigue, potential unintended consequences of efforts to reduce alert fatig

73 We highlight potential unintended consequences of language choice in scientific

74 ance for the equitable allocation of organs, unintended consequences of policy changes should be stud

75 ated to a series of predefined conditions of unintended consequences of reduced prescribing.

76 Unintended consequences of secondary prevention include

77 ting the substantial drawbacks and potential unintended consequences of the measure that could advers

78 s a benchmark for measuring potential future unintended consequences of the metric.

79 However, concerns about the unintended consequences of these APMs remain, and more w

80 Unintended consequences of this included loss of toleran

81 Our data illustrate the unintended consequences that can result from agricultura

82 However, policy changes may also have unintended consequences that must be balanced with the p

83 modulation of host immunity has intended and unintended consequences, both advantageous and disadvant

84 on, including the societal benefits and also unintended consequences, including increased costs.

85 n a boon to education and research, but with unintended consequences, including the misrepresentation

86 en generic microbiome manipulations may have unintended consequences, rendering them ineffective or e

87 that the proposed policy will have negative unintended consequences, that there are legal barriers t

88 nerally not comprehensive and are subject to unintended consequences, that there is little to no conn

89 olicy changes could trigger a broad range of unintended consequences, with profound and lasting impli

90 of the radiative effect and fail to identify unintended consequences.

91 ion of shifting water demands can help avoid unintended consequences.

92 cic surgeons who associate this with several unintended consequences.

93 e yielded disappointing results and can have unintended consequences.

94 obalisation may be worthy--but may also have unintended consequences.

95 sustainable water strategies and help avoid unintended consequences.

96 ior to widespread adoption to prevent future unintended consequences.

97 and epidemiology, and minimizing the risk of unintended consequences.

98 se an interdisciplinary approach to minimize unintended consequences.

99 ID-19 prevention in Mongolia, as well as any unintended consequences.

100 necessitates precautionary measures to avoid unintended consequences.

101 e, the potential benefits, and some possible unintended consequences.

102 increased in all mesocosms, indicating that unintended contamination may result from disposal in ana

103 The unintended cost of distributed energy sources for region

104 to better understand the best ways to avoid unintended damage when ablating near thermally sensitive

105 le convergence protects bystander cells from unintended death by promoting polarized secretion of sol

106 Herein, we report a strategy that combats unintended degradation in polymers by combining two comm

107 bolites by GC-MS revealed other significant (unintended) differences between SGT lines and the WT, bu

108 luding probing about partnership separation, unintended disclosure, gender-based violence, and stigma

109 lume thresholds alone can potentially create unintended disparities in healthcare access.

110 resent drug-signaling pathways to understand unintended drug actions and to facilitate drug discovery

111 is approach may limit opportunities to grasp unintended drug actions, which can open up channels to r

112 ug delivery to brain tumors while minimizing unintended drug leakage to the cerebrospinal fluid.

113 , when not properly implemented, resulted in unintended ecological and water security concerns at the

114 be environmentally devastating and result in unintended economic and social consequences.

115 cial role for the microbiome in limiting the unintended effects of food and drug additives in the int

116 patients and clinicians need to be aware of unintended effects of intervention.

117 te-specific DNA methylation and minimize the unintended effects of off-target DNA methylation.

118 antibiotics and Cesarean sections, may have unintended effects on babies.

119 Blocking all endocytic trafficking can have unintended effects on other receptors as well as give ri

120 There were no reported unintended effects or adverse events in either group.

121 Results indicated that unintended effects resulted from transgene flow fell wit

122 No potential unintended effects were identified in the case of the GM

123 d to food-based voucher transfers could have unintended effects, and their use needs to be carefully

124 re requirements, costs to the health system, unintended effects, facilitators, and barriers.

125 intended increases in GHG emissions or other unintended effects.

126 greater agricultural output while minimizing unintended environmental consequences is critical in the

127 The IGSM is also used to elucidate potential unintended environmental consequences of renewable energ

128 motivated by the need to address decades of unintended environmental pollution and human health impa

129 and that they cannot survive to propagate in unintended environments, is a priority.

130 Also, the unintended establishment of Wolbachia at the introductio

131 t metabolites in food crops could present an unintended exposure route to consumers.

132 Unintended exposure to teratogenic compounds can lead to

133 ls becomes more prevalent, the likelihood of unintended exposure to these materials also increases.

134 However, in contrast to (99m)Tc-MAA, an unintended extrahepatic deposition of this beta-emitting

135 e implement measure to attenuate the risk of unintended extubation in patients receiving neuromuscula

136 that apparent toxicity results may be due to unintended free wrapping agents such as polyelectrolytes

137 rrent technologies raise safety concerns for unintended gene propagation.

138 e base editor-mediated editing may result in unintended genetic modifications with distinct patterns

139 Additionally, we describe unintended genome and transcript alterations induced by

140 However, the possibility of unintended genome editing occurring through the escape o

141 ies but carries safety risks associated with unintended genomic alterations and genotoxicity.

142 No other unintended genomic alterations were observed.

143 hieve high gene expression while eliminating unintended genomic integration or the need to cross the

144 ing population and that the establishment of unintended GRNs is common to virtually every cellular en

145 rms of malnutrition; documenting examples of unintended harm caused by some undernutrition-focused pr

146 No adverse events or unintended harm were reported.

147 rogeneous clinical scenarios and may lead to unintended harms for individual patients.

148 presented neurally, but little asks how even unintended harms influence judgment.

149 tate often trumps the effect of emotions, as unintended harms may go unpunished, regardless of their

150 policies have the potential to cause severe unintended harms that could result in greater inequity,

151 response to SFA reduction, the potential for unintended health consequences of population-wide promot

152 s combined with typical food intake may have unintended health consequences, although this would requ

153 mmunities and raises concerns about possible unintended health effects.

154 ystem increased by 75%, and median number of unintended hospitalization days fell by 31%.

155 ational ASO selection can be used to prevent unintended immune suppression of TLR7.

156 that cell wall modifications can indeed have unintended impacts on plant defense, but these are not a

157 This may lead to the unintended implantation of a revision prosthesis into an

158 ements about a few nutrients, with sometimes unintended implications for science, industry, and the p

159 These findings suggest that HC use may have unintended implications for women's close relationships.

160 Less than half (45%) of pregnancies were unintended in 2011, as compared with 51% in 2008.

161 They also found no evidence of any unintended increase in suicides due to poor pain managem

162 ever, selection for disfavoured CPs leads to unintended increases in CpG and UpA dinucleotide frequen

163 ns should be taken to reduce the potentially unintended increases in GHG emissions or other unintende

164 e cycle perspective and if it will result in unintended increases in impacts to air and water quality

165 swapped, or contaminated or if they include unintended individuals.

166 heterogeneous nature of tumor tissue and the unintended induction of muscle contractions.

167 he possibility to resume the clinical use of unintended Kv11.1 blockers via pharmacological combinati

168 We found that unintended larger deletions are prevalent at multiple di

169 ases or paired Cas9 nuclease we characterize unintended larger deletions at on-target sites that freq

170 although in 2 patients, it was implanted in unintended locations: within the choroid and off center

171 on to the expected cross-coupled product, an unintended major product was generated.

172 is a useful way to detangle the intended and unintended mechanisms of drug action across diverse esse

173 (4) Could unintended medical harm result from overzealous interven

174 through specific or non-specific binding to unintended membrane protein targets.

175 epatic insulin clearance, which leads to the unintended metabolic consequence of whole-body insulin r

176 nstitutional practice with DME exhibiting an unintended minimum 3-month lapse in anti-VEGF treatment,

177 However, identification of unintended modifications, owing to the genetic modificat

178 ed pluripotent stem cell clones with minimal unintended modifications.

179 solution with an efficiency of >40%, without unintended mutagenic changes at the targeted genetic loc

180 st, heritable gene editing, the formation of unintended mutations at other genomic loci must be caref

181 rait in wheat breeding programmes might have unintended negative consequences in the future, especial

182 nce resilience and sustainability, and avoid unintended negative consequences of policy actions.

183 These findings highlight the unintended negative consequences of supplemental folic a

184 wildlife condition, they can also result in unintended negative consequences on individuals and popu

185 ed to comply with PAMA regulations and avoid unintended negative consequences on workflow and payment

186 standards for guideline development have had unintended negative consequences.

187 ations has many benefits, our results reveal unintended negative consequences.

188 Here we report an unintended negative effect of this strategy.

189 nt by 10 pp (95% CI: 1.9, 18; p = 0.016), an unintended negative impact likely due to CHVs handing ou

190 One of the unintended nitrogen (N)-loss pathways from cropland is t

191 Similarly, we filter out unintended noise by inhibiting the native SoxRS-mediated

192 of SDNs, an off-target change or edit is an unintended, nonspecific mutation occurring at a site wit

193 eterious type of DNA damage, often result in unintended nucleotide insertions/deletions (indels) via

194 culture productivity, but the possibility of unintended off-target edits has evoked some concerns.

195 of the Src family kinases, which may lead to unintended off-target effects.

196 ansgenic expression of enzymes can result in unintended off-target metabolism arising from enzyme pro

197 with Cas9 protein (94.2%), with little to no unintended off-target mutations detected.

198 LNA, hepatotoxicity can occur as a result of unintended off-target RNase H1 dependent RNA degradation

199 ently imperfect, generating large amounts of unintended off-target sequence.

200 However, the siRNA guide strand may bind unintended off-target transcripts via partial sequence c

201 t sequence homology to the target site, thus unintended off-targets might additionally be cleaved.

202 ic targets for drug-like molecules, or their unintended 'off-targets' that predict adverse drug react

203 uickly identify new promising (on-target) or unintended (off-target) effects of drugs.

204 any modified alleles generated by CRISPR, as unintended on-target effects that fail to be detected by

205 resulting in the evolution of products with unintended or suboptimal function.

206 dispersion and also illuminates potentially unintended or unanticipated effects of varying dendrimer

207 An unintended outcome was observed in the FFV arm: a negati

208 to precisely edit the genome can often yield unintended outcomes.

209 l, and to track their impact on intended and unintended outcomes.

210 endogenous or exogenous stimuli can lead to unintended pathology.

211 g-lasting APs and guard the membrane against unintended perturbation.

212 practice of using one sgRNA can produce both unintended plasmid integration and desired locus replace

213 ial of APOBEC-based base editors in inducing unintended point mutations outside of likely in silico-p

214 However, two unintended potential harms of such approaches are medica

215 131.5), corresponding to a global rate of 64 unintended pregnancies (UI 60-70) per 1000 women aged 15

216 ely implemented, this practice could prevent unintended pregnancies after use of emergency contracept

217 ffers an unprecedented opportunity to reduce unintended pregnancies among adolescents because it is h

218 alth care could help millions of women avoid unintended pregnancies and ensure access to safe abortio

219 nception planning is very important to avoid unintended pregnancies and to minimize risk of congenita

220 ivate and inform efforts to help women avoid unintended pregnancies and to monitor progress toward th

221 In 2015-19, there were 121.0 million unintended pregnancies annually (80% uncertainty interva

222 61% (58-63) of unintended pregnancies ended in abortion (totalling 73.3

223 e abortion was restricted, the proportion of unintended pregnancies ending in abortion had increased

224 rate has declined, whereas the proportion of unintended pregnancies ending in abortion has increased.

225 role of vouchers in empowering WLWH to avoid unintended pregnancies over time.

226 ned substantially between 2008 and 2011, but unintended pregnancies remained most common among women

227 Adolescents have higher rates of unintended pregnancies than any other age group.

228 The percentage of unintended pregnancies that ended in abortion remained s

229 and girls 15 to 44 years of age, the rate of unintended pregnancies that ended in birth declined from

230 ed week 48 levonorgestrel concentrations and unintended pregnancies.

231 n immunodeficiency virus (HIV) infection and unintended pregnancies.

232 proportionally affected by HIV infection and unintended pregnancies.

233 ran Africa are at risk for HIV infection and unintended pregnancies.

234 the intervention to reduce the incidence of unintended pregnancy among sex workers in Kenya compared

235 Rates of unintended pregnancy among those who were below the fede

236 The rate of unintended pregnancy among women and girls 15 to 44 year

237 Unintended pregnancy and abortion estimates document tre

238 new statistical model that jointly estimated unintended pregnancy and abortion that aimed to better i

239 l that simultaneously estimated incidence of unintended pregnancy and abortion within a Bayesian fram

240 enges for measuring and monitoring trends in unintended pregnancy and abortion.

241 ps, we found an inverse relationship between unintended pregnancy and income, whereas abortion rates

242 owed between 2008 and 2011; the incidence of unintended pregnancy declined by more than 25% among gir

243 sible contraceptive (LARC) methods to reduce unintended pregnancy in the St.

244 evious period of minimal change, the rate of unintended pregnancy in the United States declined subst

245 The rate of unintended pregnancy in the United States increased slig

246 ended at least one follow-up visit, compared unintended pregnancy incidence between groups using disc

247 The intervention had no measurable effect on unintended pregnancy incidence.

248 en with HIV-associated tuberculosis (TB), as unintended pregnancy is associated with increased perina

249 ation subgroups, disparities in the rates of unintended pregnancy persisted but narrowed between 2008

250 Between 1990-94 and 2015-19, the global unintended pregnancy rate has declined, whereas the prop

251 red with the proportion for 1990-94, and the unintended pregnancy rates were higher than in countries

252 Unintended pregnancy remains a serious public health cha

253 Incidence of unintended pregnancy was 15.5 per 100 person-years in th

254 and HSV-2), and levonorgestrel (LNG; targets unintended pregnancy).

255 e health and in particular the prevention of unintended pregnancy.

256 y transmitted infections, including HIV, and unintended pregnancy.

257 f HIV, HSV-2 and HPV acquisition, as well as unintended pregnancy.

258 ased risk of HIV-1 acquisition) and prevents unintended pregnancy.

259 of DMPA as a contraceptive option to prevent unintended pregnancy.

260 d middle-income countries face high risks of unintended pregnancy.

261 rgency contraception, they remain at risk of unintended pregnancy.

262 ition, inadequate access to health care, and unintended pregnancy.

263 nd communicate the risk of reaction from the unintended presence of allergens in foods.

264 unicate the possibility of reaction from the unintended presence of allergens in foods.

265 y contain' labelling to address the issue of unintended presence of allergens; these therefore need t

266 The use of PAL should indicate the possible, unintended presence of an allergen in a consumed portion

267 containment strategies are needed to prevent unintended proliferation of GMOs in natural ecosystems.

268 as they indicate that such tagging can cause unintended protein destabilization and concomitant effec

269 ng from COL to FIT results in an incremental unintended psychological harm of 16 additional positive

270 serve undermines the policy by triggering an unintended race-to-fish.

271 between free V1 and Vo functions to prevent unintended reassembly of holo V-ATPase when activity is

272 el reactive antibodies are transplanted into unintended recipients, most commonly due to positive phy

273 d in a very low rate of transplantation into unintended recipients.

274 ilize novel ground states yet can also cause unintended reconstructions in devices.

275 ons of Caucasian descendants has resulted in unintended reduction of power in studying non-Caucasians

276 ilability, health effects (both intended and unintended), research and development investments, quali

277 e internal initiation regions were likely an unintended result of the codon optimization for E. coli

278 integrated approaches, mindful of potential unintended results, are needed to ensure sustained, worl

279 bsequent esophagitis and BE can be a serious unintended sequalae.

280 medications that block hERG1 channels as an unintended side effect also increase arrhythmic risk.

281 term solutions exist to resolve this serious unintended side effect of radiotherapy.

282 rgical strategies may help to mitigate these unintended side effects of IOL implantation.

283 Transgene insertions might have unintended side effects on the transgenic host, both cro

284 e along a thin ferromagnetic film as well as unintended side effects which hinder an unambiguous dete

285 shape control of nanomaterials and reducing unintended side effects.

286 An unintended, single, relatively short-term lapse in anti-

287 ts of RMTg bicuculline infusions were due to unintended spread of drug to the nearby VTA was falsifie

288 he question about our ability to prevent the unintended spread of such drives from the laboratory int

289 nded pharmacologic target (type A ADR) or an unintended target (type B ADR).

290 duce hybridization-dependent mis-splicing of unintended targets has not been systematically studied.

291 ary mitochondrial diseases and are often the unintended targets of various clinically useful antibiot

292 however, simultaneously increase affinity to unintended targets with partial sequence complementarity

293 hat can result from covalent modification of unintended targets.

294 ance of cross-reactivity against epitopes in unintended targets.

295 of leukocyte activation is critical to limit unintended tissue injury during acute inflammation.

296 patotoxic LNA ASOs, while the levels of many unintended transcripts were reduced in mice treated with

297 down of human HTT and minimized silencing of unintended transcripts.

298 s study is to characterize the effects of an unintended treatment lapse in patients with DME undergoi

299 requent visits, which increases the risk for unintended treatment lapses.

300 Unintended weight loss is a hallmark of Huntington disea

301 eed and the excretion via manure leads to an unintended Zn input to agricultural systems, which might