ライフサイエンスコーパス: unitary conductance

1 ctivity and permeation properties, including unitary conductance.

2 ovalent-specific cation channel with a 23 pS unitary conductance.

3 ) to more negative potentials, and decreased unitary conductance.

4 stinguished by their fast kinetics and large unitary conductance.

5 obability of Kv7.4 channels without changing unitary conductance.

6 -channel open probability but did not change unitary conductance.

7 lo-alpha channels 3.3-fold without affecting unitary conductance.

8 ) channel open probability without affecting unitary conductance.

9 e presence of ATP and cGMP without affecting unitary conductance.

10 and NR2 leads to the appearance of a smaller unitary conductance.

11 from KIR6.2 channels mainly by their smaller unitary conductance.

12 er because of a smaller open probability and unitary conductance.

13 annel open probability without affecting the unitary conductance.

14 significant effect on mean open lifetime or unitary conductance.

15 r K(+) channels, and significantly increases unitary conductance.

16 voltage- and Pi-dependent activity and large unitary conductance.

17 w monodisperse, cation-selective channels of unitary conductance.

18 the +3 channel has the highest time-averaged unitary conductance.

19 to larger conductances rather than altering unitary conductance.

20 POPG increases both the open probability and unitary conductance.

21 increased chloride permeability and reduced unitary conductance.

22 lectivity, low Cs(+) permeability, and small unitary conductance.

23 e distal half of the N-terminus controls the unitary conductance.

24 ecause of its fast gating kinetics and large unitary conductance.

25 channel long-closed states without modifying unitary conductance.

26 rences in transjunctional voltage gating and unitary conductance.

27 uppress cumulative inactivation and increase unitary conductance.

28 ter single-channel gating characteristics or unitary conductance.

29 ity and relatively little, if any, effect on unitary conductance.

30 ncentrations, and the modest increase in the unitary conductance.

31 onstant is similar for channels of different unitary conductances.

32 g agents, allowing identification of 4 major unitary conductances.

33 de, different ion selectivities, and diverse unitary conductances.

34 flects a combination of open probability and unitary conductance(1).

35 Unitary conductance (140 mM [K+]o) was also little affec

36 sitive alpha7-containing nAChRs have a small unitary conductance (18 pS), brief open time kinetics an

37 l littermate mice there were three principal unitary conductance - 22 pS, 111 pS and 178 pS.

38 nel currents with outward rectification, and unitary conductance (~30 to 70 pS).

39 Cell-attached recordings revealed three unitary conductances: 5 to 6 pS, 10 to 12 pS, and 20 to

40 he single-channel level, we observed reduced unitary conductance accompanied by spontaneous opening e

41 ntent of the MT channel sets the gradient in unitary conductance along the cochlea.

42 nnels with a similarly broad distribution of unitary conductance amplitudes are also observed in reco

43 actin filaments caused a 2-fold decrease in unitary conductance and a 2-fold increase in open probab

44 tes, can result in a threefold difference in unitary conductance and alter the direction and amount o

45 llular N-terminus substantially increase the unitary conductance and cation selectivity of the chimer

46 TRPC1 subunits are important in determining unitary conductance and conferring channel activation by

47 Receptors lacking the N1 CTDs had larger unitary conductance and faster deactivation kinetics, re

48 PsChR exhibited approximately 3-fold higher unitary conductance and greater relative permeability fo

49 s of the protein, that when mutated, affects unitary conductance and ion selectivity, and modulates p

50 ion from hair cells, and alter the channel's unitary conductance and ion selectivity.

51 divalent cations have marked effects on the unitary conductance and kinetic behaviour of non-selecti

52 atches of rabbit portal vein myocytes with a unitary conductance and kinetic properties that are simi

53 Unitary conductance and maximum open probability were un

54 PKP2 deficient mice, but the K(ATP) channel unitary conductance and nucleotide sensitivities remaine

55 ever, cholesterol level had no effect on the unitary conductance and only little effect on the open p

56 at synapses, channels with an unusually low unitary conductance and open-channel noise.

57 provide a basis for understanding the small unitary conductance and pharmacology of K(Ca)2.x channel

58 e substitutions at the 5th position decrease unitary conductance and produce a non-selective channel

59 strate a site contributing to rectification, unitary conductance and proton sensitivity in these Kir

60 , faster whole-cell desensitization) reduced unitary conductance and spontaneous opening events.

61 ate that TRP-dependent channels have a small unitary conductance and that many channels can be gated

62 + channel, albeit partially, to decrease the unitary conductance and to stabilize the open conformati

63 lar interactions in the establishment of the unitary conductance and voltage-dependent profile of Cx4

64 248 of Cx40 yielded a chimeric channel with unitary conductance and voltage-gating profile indisting

65 pore of the channel depending on the state, unitary conductances and gating properties of each hemic

66 K(+) ions over Na(+) ions, generate a large unitary conductance, and are only weakly voltage depende

67 terized by exquisite Ca(2+) selectivity, low unitary conductance, and low permeability to large catio

68 mbination of weak voltage sensitivity, small unitary conductance, and permeation by anions as large a

69 (69 amino acids long) in the control of the unitary conductance, and role of the alternative transla

70 KCNKO exhibits concentration-dependent unitary conductance, anomalous mole fraction behavior, a

71 The unitary conductance ( approximately 250 pS; 220/20 mM Cs

72 ce for cations over anions, yet have a large unitary conductance (approximately 300 pS) and a relativ

73 Cx50 gap junction channel open stability and unitary conductance are shaped by structural and dynamic

74 The MET channel unitary conductance, assayed by single-channel recording

75 ectified, K+-specific current with a 10.8 pS unitary conductance at -100 mV.

76 We analyzed the unitary conductance at femtosiemens resolution of all fo

77 The unexpectedly high unitary conductance at low salt concentrations can be ex

78 alysis was applied to estimate AMPA-receptor unitary conductance before and after LTD induction in a

79 The K(ATP) channel unitary conductance, block by MgATP and activation by Mg

80 This manipulation did not modify unitary conductance, but decreased the frequency of tran

81 nce of K(+) channel populations with similar unitary conductances, but distinct channel kinetics and

82 eceptor/Cl- channels including open time and unitary conductance changed independently of the presenc

83 G-evoked channel activity, with no change in unitary conductance, channel mean open times or burst du

84 The unitary conductances, channel kinetics, and other charac

85 displaying voltage dependence, kinetics, and unitary conductance characteristic of native T-type Ca2+

86 x37 yielded a chimera channel with increased unitary conductance close to that of Cx37.

87 cell-attached patch clamp showed comparable unitary conductance, current-voltage data, and open prob

88 -15 pS (n = 15 cell pairs); despite this low unitary conductance, Cx36 channels were permeable to the

89 Unitary conductance decreased thus: Ba2+ > Ca2+ (14.5 pS

90 The pores showed an up to 70% reduction in unitary conductance, depending on the length of the inse

91 annels formed in the A7r5 cells display many unitary conductances distinct from homomeric/homotypic C

92 Thus, changes in unitary conductance do not contribute to current upregul

93 average the values fell within the range of unitary conductances estimated previously for synaptic A

94 lthough RyR1 channels exhibited the expected unitary conductance for Cs(+) in bilayer lipid membranes

95 currents in cell-attached patches yielded a unitary conductance for Kir7.1 of approximately 2 pS.

96 l-attached apical membrane patches yielded a unitary conductance for RPE Kir of approximately 2 pS.

97 issociation constant (Ki) for amiloride, and unitary conductances for delta alpha beta gamma-ENaC dif

98 idney (HEK) cells (150 mM external KCl), the unitary conductances form a broad distribution, ranging

99 the density of functional channels and their unitary conductance (from 20 to 11 pS).

100 Cx50D3E gap junction channels showed reduced unitary conductance (gamma(j)) of the main open state, r

101 P(o) x number channels; N) and decreased the unitary conductance (gamma) of BK channels.

102 However, the unitary conductance (gamma) of neuronal somatodendritic

103 was to chart the concentration-dependence of unitary conductance (gamma) to physiological Ca concentr

104 Although the unitary conductance (gamma) was much greater with barium

105 Transfectants revealed maximum unitary conductances (gamma(j)) of 135 pS for Cx26 and 5

106 In particular, the unitary conductance, gamma, of HCN channels is highly co

107 lpha3beta4)2alpha3-nAChR function [decreased unitary conductance (>/=50%), altered burst proportions

108 rrents, including glycine-requirement, large unitary conductance, high Ca(2+) permeability, and volta

109 nels, i.e., selective to K(+) ions, of 56 pS unitary conductance in the presence of 5 mM external K(+

110 The unitary conductances in patches with a single active cha

111 Cation channels with unitary conductance, ion selectivity and Ca2+-dependence

112 BK channels are large unitary conductance K(+) channels cooperatively activate

113 nnels that differ from the homomers in their unitary conductance, kinetic behavior, subcellular local

114 ely 52 pS) and large ( approximately 220 pS) unitary conductance levels.

115 The average maximum unitary conductances measured in KCl were 175 pS (30 mM)

116 Neither the unitary conductance nor the characteristics of the volta

117 atches evoked single channel currents with a unitary conductance of 1.9 pS.

118 MERS E conducts K(+) ions with a unitary conductance of 113 picosiemens, fivefold larger

119 ajority of spontaneous cation channels had a unitary conductance of 13 pS and Vr was shifted to +4 mV

120 lysis of sheep Kir2.3 channels showed a mean unitary conductance of 13.1+/-0.1 pS in 15 cells, which

121 ents revealed single-channel activity with a unitary conductance of 137 pS.

122 y activated by Gbetagamma subunits and has a unitary conductance of 16 pS.

123 ening of apamin-sensitive K+ channels with a unitary conductance of 17.0+/-0.2 pS.

124 d folds, LukF and LukS produce a pore with a unitary conductance of 2.5 nS [1 M KCl and 5 mM HEPES (p

125 non-selective cation channel currents with a unitary conductance of 2.6 pS which were not inhibited b

126 Single-channel currents had a unitary conductance of 210 pS, typical of Cx50.

127 was -1.81 +/- 0.2 pA, which corresponds to a unitary conductance of 22 pS.

128 patches spontaneous channel currents with a unitary conductance of 23 pS were observed.

129 jority of spontaneous channel currents had a unitary conductance of 23 pS, reversal potential (Vr) of

130 sensitive single-channel K(+) current with a unitary conductance of 246-pS in freshly isolated corona

131 ed patches, we detected single channels with unitary conductance of 3.2 pS, reversal potential of +72

132 The E158N Kir4.1 mutant had a unitary conductance of 35 pS and a midpoint pH for chann

133 97 elicited single-channel activities with a unitary conductance of 40 pS.

134 tuted taste epithelial membranes: one with a unitary conductance of 40-60 pS, and the other with a co

135 ative potentials and (iii) had an underlying unitary conductance of 43 pS rather than the 12 pS seen

136 a tolbutamide-sensitive channel exhibiting a unitary conductance of 44.1 pS.

137 road anion selectivity and the channel has a unitary conductance of 5-7 picosiemens.

138 a7 antisense treatment is characterized by a unitary conductance of 50 pS and prolonged opening durat

139 luctuations in planar lipid bilayers, with a unitary conductance of 57 pS in 1 M KCl and numerous lar

140 single-channel level, the T6'S mutant has a unitary conductance of 61.7 +/- 5.8 pS, similar to that

141 Single Ca(2+)-activated Cl() channels with a unitary conductance of 7.8 pS were resolved in excised p

142 ll membranes to form channels that exhibit a unitary conductance of 70-100 picosiemens under physiolo

143 mbrane, ATP- and PKA-dependent gating, and a unitary conductance of 8 picosiemens (pS).

144 minor component was attributable to reduced unitary conductance of 8-12 %.

145 mM KCl, the skeletal muscle NMCC exhibits a unitary conductance of ?160 pS and high, voltage-indepen

146 out patches and these channel currents had a unitary conductance of about 2 pS.

147 atches evoked single-channel activity with a unitary conductance of about 23 pS and with similar kine

148 Slack channels rectify outwardly with a unitary conductance of about 25-65 pS and are inhibited

149 In 110 mM Ba(2+), unitary conductance of alpha(1S) is approximately half t

150 ation of PKA signaling pathway decreases the unitary conductance of alpha3GlyRs.

151 ly rectifying K+ (GIRK)1 and GIRK4, and have unitary conductance of approximately 35 pS with symmetri

152 tive to levcromakalim and glibenclamide with unitary conductance of approximately 35pS.

153 re in planar lipid bilayers, with a measured unitary conductance of approximately 4.8 nanosiemens, wh

154 constituted into planar lipid bilayers had a unitary conductance of approximately 50 pS, were highly

155 d(3+) -sensitive Ca(2+) influx channels with unitary conductance of approximately 56 pS.

156 a voltage-dependent K(+) channel that has a unitary conductance of approximately 60 pS.

157 The V140T mutation in Kir1.1 led to a unitary conductance of approximately 70 pS, and the G210

158 d a significant decrease in the synaptic and unitary conductance of CA1 pyramidal neuron GABA(A) rece

159 argazin, we found that the rectification and unitary conductance of channels underlying excitatory po

160 e (V(j)) gating sensitivity, and reduced the unitary conductance of Cx45.6-43N gap junctional channel

161 ting sensitivity, open-closed stability, and unitary conductance of Cx50 gap junction channels.

162 that although cholesterol did not affect the unitary conductance of GIRK2, it significantly enhanced

163 n other experiments, high Mg(2+) reduced the unitary conductance of hCx37 homotypic gap junction chan

164 ver, noise analysis showed that the apparent unitary conductance of kainate-type channels is signific

165 Since the unitary conductance of KCNQ3 is five- to 10-fold greater

166 The unitary conductance of KirNB was 23 pS (155 mM [K(+)](o)

167 Unitary conductance of mCx30.2 hemichannels was approxim

168 e nanopore exhibits a reversible increase in unitary conductance of more than 20-fold upon irradiatio

169 mice harboring an Lhfpl5 null mutation, the unitary conductance of outer hair cell mechanotransducer

170 n the synaptic cleft may change the apparent unitary conductance of postsynaptic AMPA receptors.

171 Single gBK channels have a unitary conductance of similar250 pS, and the currents s

172 In 1.5 mM [Ca(2+)](o) the unitary conductance of SOCs was significantly greater in

173 The unitary conductance of the channel underlying I(A) was u

174 ing a subsequent attenuation of the apparent unitary conductance of the channel.

175 ct reflected, at least in part, an increased unitary conductance of the channels underlying the EPSCs

176 The unitary conductance of the channels was sensitive to the

177 gation was found in a separate study for the unitary conductance of the channels.

178 In 3 microM and 100 microM Ca2+o the unitary conductance of the single channel currents was b

179 The unitary conductance of the two splice variants were appr

180 e (V(j)) gating sensitivity, and reduced the unitary conductance of this Cx40E9,13K gap junction chan

181 no-terminal half of M1 replaced retained the unitary conductance of wild-type Cx46.

182 -type Cx43, with normal voltage gating and a unitary conductance of ~110 pS.

183 gadolinium, mediated by hemichannels with a unitary conductance of ~250 pS, and was not due to eleva

184 into a planar lipid bilayer revealed a large unitary conductance of ~8.3 nS.

185 however, detect AMPA receptors with apparent unitary conductances of <1 pS in patches from both migra

186 to steady levels roughly proportional to the unitary conductances of 35%, 50%, and 100% that the agon

187 -AM) both evoked channel currents, which had unitary conductances of approximately 2 pS.

188 Three principal unitary conductances of around 18 pS, 118 pS and 185 pS

189 The unitary conductances of F380I, F380Y and wild-type chann

190 the model revealed the relationship between unitary conductances of hemichannels and GJ channels and

191 Unitary conductances of KCNQ2 and KCNQ3 (6.2 and 8.5 pS,

192 ls 0.5; 3), the gating polarity; and 4), the unitary conductances of the gates and their rectificatio

193 abbit sarcoplasmic reticulum with respect to unitary conductance, open dwell times, and responses to

194 ngs showed that acidification did not affect unitary conductance or block the hemichannel but rather

195 eater constitutive activity and no change in unitary conductance or rectification.

196 Indole does not noticeably change the unitary conductance or the mean open duration, however,

197 s oocytes, with no change in mean open time, unitary conductance, or reversal potential, indicating a

198 obability, with no change in mean open time, unitary conductance, or reversal potential; (2) an incre

199 channels formed by these proteins differ in unitary conductance, permeability, and regulation.

200 Cx43 (heterodomain interactions) rescued the unitary conductance profile of Cx40.

201 Unitary conductance properties of I(K1) were unaffected

202 same as those opened by ATP, with respect to unitary conductance, rectification, and permeability of

203 native cardiac IKr channels in their gating, unitary conductance, regulation by potassium, and distin

204 ty (NPo) elicited by capsaicin, although the unitary conductance remained unaltered.

205 The unitary conductance, reversal potential and mean open ti

206 InsP3- and heparin-sensitive channels with a unitary conductance similar to native InsP3Rs.

207 Using weakly coupled pairs, we observed two unitary conductance states: 85 pS (85-90% of events) and

208 Moreover, an increase in the unitary conductance, steady state probability of hemicha

209 efold to fourfold but had no effect on their unitary conductances, suggesting that the increase in ma

210 TRPM4b encodes a cation channel of 25 pS unitary conductance that is directly activated by [Ca2+]

211 from a variety of limitations including low unitary conductance, the need to modify the target chann

212 First, it increased unitary conductance through individual channels.

213 e, trans-ions and state (and to have a lower unitary conductance): thus, the KCNQ1 mutations alter th

214 verse mutation in Kir1.1 (N171E) reduced the unitary conductance to 27 pS (23 pS in WT Kir4.1).

215 Both drugs diminished BK channel unitary conductance to a degree that paralleled the effe

216 lpha(1C) with P-loops from alpha(1S) reduced unitary conductance to a value intermediate between thos

217 ically, while injecting controlled trains of unitary conductance transients, to electrically mimic na

218 receptor from the motor end plate decreases unitary conductance up to 80%.

219 Two mean unitary conductance values ("lower conductance" and "mai

220 no voltage dependence to their gating, small unitary conductance values and sensitivity to the bee ve

221 res with very long loops (n = 14 and 21) had unitary conductance values close to those of W(7), sugge

222 Moreover, the pattern of unitary conductance values obtained for chimeras in whic

223 terotetrameric channels exhibit intermediate unitary conductance values with respect to the homotetra

224 attached and inside-out patches with similar unitary conductance values.

225 in detached patches showed similar levels of unitary conductance, voltage, and Ca2+ sensitivity in K(

226 Kv3.4 channels differ from Kv3.4 channels in unitary conductance, voltage-dependent activation, recov

227 Unitary conductance was described by a Langmuir isotherm

228 Unitary conductance was not affected by PIP2.

229 was shifted to more negative values and the unitary conductance was reduced when part of the externa

230 KAK, and AKK channels, and amplitude of the unitary conductances was in all cases not different from