ライフサイエンスコーパス: unliganded

1 mplex with lipid A disaccharide backbone and unliganded.

2 lcholine- (POPC-) only nanodiscs in both the unliganded (4.1- angstrom resolution) and agonist-bound

3 equilibrium constants, we estimate that the unliganded AChR gating constant is E(0) approximately 6.

4 n AChRs is approximately 1.15 x 10(-7); (ii) unliganded AChRs open for approximately 80 micros, once

5 ystal structure of a synaptic tetramer of an unliganded activated mutant (M114V) of the G-segment inv

6 tations in the cytosolic loops that increase unliganded activity.

7 ich hinders the conformational change of the unliganded alpha-CT required for binding of a second IGF

8 T forms a rigid beam-like structure with the unliganded alpha-CT, which hinders the conformational ch

9 rikingly different conformations of LIMBS in unliganded alphaIIbbeta3 versus alphaVbeta3, the result

10 s CD4-bound state, compare this structure to unliganded and antibody-bound forms to identify structur

11 1 ortholog from the giant Mimivirus (MvNei1) unliganded and bound to DNA containing tetrahydrofuran (

12 ions (CDRs) of the TCR seen in comparison of unliganded and bound X-ray structures, NMR characterizat

13 igate full-length, glycosylated HIV gp120 in unliganded and CD4-bound forms by using small-angle X-ra

14 conformational stability for HIV-1 gp120 in unliganded and CD4-bound states.

15 ot bind to the YecSC transporter and closed, unliganded and closed, liganded forms that bind this tra

16 onding loop in MvNei1 is ordered in both the unliganded and furan-bound structures, unlike other Fpg/

17 namics, respectively, demonstrates that both unliganded and glucose-bound enzymes sample multiple con

18 Models of E. coli ACPS in unliganded and holo-ACPP-bound forms solved by X-ray cry

19 utative binding region of SrpA (SrpABR) both unliganded and in complex with a synthetic disaccharide

20 These studies show that unliganded and inverse-agonist-bound beta2AR exists pred

21 results uncover a paradoxical action of the unliganded and ligand-activated PPARgamma in regulating

22 ase from Streptococcus pneumoniae (SpNic) in unliganded and ligand-bound forms.

23 ible for differential regulation of genes by unliganded and liganded ERbeta.

24 genes, we identified genes regulated by the unliganded and liganded forms of ERalpha and ERbeta in U

25 Our findings indicate that the unliganded and liganded forms of ERbeta regulate three c

26 ences of specific mutations on gating in the unliganded and liganded states.

27 The comparison of unliganded and liganded structures reveals a quaternary

28 s shows that they are tightly coupled in the unliganded and single agonist-bound form and only upon b

29 Both the unliganded and the AMP-bound ADPGK structures are in the

30 Crystal structures of gp120 in unliganded and various ligand-bound states, meanwhile, r

31 nogen o-gp140DeltaV2TV1, in both its native (unliganded) and CD4-induced (liganded) states by cryoele

32 AR adopted a conformation that resembled the unliganded AR (apo-AR), precluding nuclear localization

33 of heat shock protein (HSP90) that binds to unliganded AR in the cytoplasm, restricting its entry in

34 with AR-FL to induce nuclear localization of unliganded AR-FL, AR-V7 does not need to interact with A

35 nt exposed out orientation typically seen in unliganded aromatic hydroxylases.

36 structure of a MAM mutant K201A in apo form (unliganded) at 2.8-A resolutions.

37 ation promotes beta-arrestin2 recruitment to unliganded AT1 angiotensin receptor (AT1R).

38 in ANS emission observed in the presence of unliganded ATH reflects the interaction of these hydroph

39 ts a compact or "closed" domain arrangement, unliganded avian SC is flexible and exists in both close

40 egulatory sites; ii) a simulated ensemble of unliganded Bcl2 structures reveals extensions of a known

41 ct is overrun by a concomitant activation of unliganded binding sites.

42 a component of secretory antibodies, or when unliganded, binds and excludes bacteria.

43 stal structure of the constitutively active, unliganded BmrR mutant BmrR(E253Q/R275E).

44 lex, and (d) the binding interaction between unliganded C-Mad2 and Cdc20 cannot be catalyzed by a C-M

45 a C-Mad2-Cdc20 complex >300-fold slower than unliganded C-Mad2, (b) a stable C-Mad2-Mad1 core complex

46 The crystal structures of the unliganded CAP containing a D138L mutation and the unlig

47 arison of the structures of the liganded and unliganded CAP suggests that cAMP stabilizes the active

48 The rate constants for unliganded channel opening and closing were also estimat

49 this electrostatic interaction also promotes unliganded channel opening in the absence of ATP binding

50 pping in the liganded channel but not in the unliganded channel.

51 A comparison of the unliganded cis-CaaD crystal structure with that of an in

52 structural models that likely represent the unliganded closed-channel conformation and the fully lig

53 nto lipid nanodiscs that are captured in the unliganded (closed), glycine-bound (open and desensitize

54 re in equilibrium with a minor population of unliganded, closed species.

55 The X-ray crystal structures of unliganded Co(2+)(2)-HAI determined at 2.10 A resolution

56 Comparison of structures of dimers of unliganded CodY and CodY-Ile derived from the tetramers

57 ranched-chain amino acids, we concluded that unliganded CodY cannot repress transcription in vivo and

58 ghts, we determined the crystal structure of unliganded CodY from Bacillus subtilis revealing a 10-tu

59 In the unliganded ColH structure, this globular dynamics is mod

60 e that PBPs typically adopt either an "open" unliganded configuration or a "closed" liganded one.

61 The DADH crystal structure comprises an unliganded conformation and a product-bound conformation

62 s of the so-far structurally uncharacterized unliganded conformation of HIV-1 gp120, which may prove

63 that bind conserved epitopes exposed on the unliganded conformation of the HIV-1 envelope glycoprote

64 econdary structure elements reveals that the unliganded conformations of both glycoprotein (gp)120 an

65 On average, unliganded core gp120 displayed >10,000-fold slower exch

66 tically, we determined crystal structures of unliganded core gp120 from HIV-1 clades B, C, and E.

67 We report the crystal structures of the unliganded D462-E4 TCR and its complex with MR1 presenti

68 re, we report the X-ray crystal structure of unliganded DCS at 2.4 A resolution and the structure of

69 autoinhibitory interdomain interactions hold unliganded dEGFR in an inactive state.

70 tically for the liganded complex compared to unliganded demethylase, which may correspond to the obse

71 ngaging the proapoptotic activity induced by unliganded dependence receptors are in late-stage precli

72 gate directly the effect of the JM domain on unliganded dimer stability of FGFR3, a receptor that is

73 ns are critical for the establishment of the unliganded dimer structure, and for the transition to th

74 point to a coordinated stabilization of the unliganded dimeric state of FGFR3 by its JM and TM domai

75 Our data reveal a correlation between unliganded dimerization and tumorigenic signaling and su

76 ers in the absence of ligand, and that these unliganded dimers are phosphorylated.

77 The data suggest that FGFR3 unliganded dimers are stabilized by receptor-receptor co

78 ny of these receptors are capable of forming unliganded dimers that are likely important intermediate

79 Although the kinetic stability of unliganded dimers was in principle sufficient for EGF-in

80 ctures of B3GNT2 have been determined in the unliganded, donor substrate-bound, acceptor substrate-bo

81 liganded during human pregnancy, it becomes unliganded during both term and preterm labour as a resu

82 that exploited the repressor capacity of the unliganded EcR, making it a hormone-controlled gateway f

83 presses genes that are normally repressed by unliganded EcR, thereby allowing wing patterning to prog

84 and that this structure is inhibited by the unliganded ectodomain.

85 catalytic phosphorylation of tyrosine 845 on unliganded EGFR monomers is suppressed by vesicular recy

86 region studied in the context of either CD4-unliganded Env trimer or the gp41 peptide in the unbound

87 contribute to interprotomer contacts in the unliganded Env trimer, undergo rearrangement upon CD4 bi

88 on contributes to gp120 association with the unliganded Env trimer.

89 In the unliganded Env, intersubunit interactions maintain the g

90 at engage subunit interfaces upon binding to unliganded Env.

91 s where the loop is generally ordered in the unliganded enzyme or in complexes with a lesion, and dis

92 ed to the catalytic site than in the case of unliganded enzyme or the WT enzyme-Mg(2+)-3-hydroxygluta

93 In the unliganded enzyme, we observed a rather broad distributi

94 l any substantial movement compared with the unliganded enzyme.

95 atible with substrate binding as seen in the unliganded enzyme; (ii) the active "on state" seen in in

96 Oxydianions bind weakly to these unliganded enzymes and tightly to the transition state c

97 Indeed, our data reveal that activation by unliganded ERalpha and repression by estrogen-activated

98 emonstrated that in MCF7 breast cancer cells unliganded ERalpha binds to more than 4,000 chromatin si

99 re, these results suggest a pivotal role for unliganded ERalpha in controlling a fundamental caretake

100 estrogen, suggesting an unexpected role for unliganded ERalpha in E-cadherin transcription.

101 ased upon ERalpha silencing, suggesting that unliganded ERalpha participates, together with other fac

102 t virtually no gene regulation occurred with unliganded ERalpha, whereas many genes were regulated by

103 strogen-induced binding sites, we found that unliganded-ERalpha binding is specifically linked to gen

104 The observation that the unliganded ErbB2 kinase preferentially serves as the act

105 ing, imply that the tethered conformation of unliganded ErbBs evolved to prevent crosstalk among ErbB

106 ereas class III genes were regulated by both unliganded ERbeta and E(2).

107 Class I genes were regulated primarily by unliganded ERbeta.

108 estrogen, the results demonstrate a role for unliganded ESR1 in CYP3A4 expression consistent with unl

109 ed ESR1 in CYP3A4 expression consistent with unliganded ESR1 signaling reported in other cell types.

110 Furthermore, we show that the unliganded extended monomeric core of gp120 (coree) assu

111 Trp/Arg(H100)Trp double mutant (1E9dm) as an unliganded Fab at 2.05 A resolution and in complex with

112 Although the existence of unliganded FGFR1 dimers on the surface of living cells h

113 his approach we observed homodimerization of unliganded FGFR1 that is independent of its surface dens

114 he JM domain and a TM pathogenic mutation on unliganded FGFR3 dimer stability are additive.

115 rmation being significantly populated in the unliganded FKBP51 domain is more consistent with a confo

116 xide (TMAO), an osmolyte that stabilizes the unliganded folded form of the protein, enabled us to stu

117 otein fromPseudomonas putidaCSV86 (ppGBP) in unliganded form (2.5 A) and complexed with glucose (1.25

118 g from Archaeoglobus fulgidus, AfUbiA, in an unliganded form and bound to Mg2+ and two different isop

119 the X-ray crystal structures of NolR in the unliganded form and complexed with two different 22-base

120 ructures of the catalytic domain of hPARG in unliganded form and in complex with three inhibitors: AD

121 ase in the melting temperature compared with unliganded form and ppGBP-galactose complex.

122 Klebsiella pneumoniae OHCU decarboxylase in unliganded form and with bound allantoin.

123 The unliganded form of nitroxide spin-labeled HIV-1 protease

124 The crystal structure of the unliganded form of the interleukin-7 alpha receptor (IL-

125 protein (Env) trimer maintain the metastable unliganded form of the viral spike.

126 conformational equilibrium between an open, unliganded form that does not bind to the YecSC transpor

127 e report the structure of this domain in its unliganded form, allowing definition of the structural c

128 of the catalytic core of yeast Pol alpha in unliganded form, bound to an RNA primer/DNA template and

129 ural snapshots of EndoBT-3987, including the unliganded form, the EndoBT-3987-Man(9)GlcNAc(2)Asn subs

130 In the unliganded form, the same loop points away from the acti

131 trinsically accessible to the protein in the unliganded form.

132 ith lipid A carbohydrate backbone and in the unliganded form.

133 ructural comparisons of various liganded and unliganded forms of CCR and CAD2 highlight substantial c

134 uctural comparisons of antibody-liganded and unliganded forms of CD3epsilon from a single species, wh

135 The structures of three unliganded forms of S25-26 have a labile complementary-d

136 Thus the liganded and the unliganded forms of the CSD respectively provide the str

137 (proportional, variant 1/KD(in)) and slower unliganded "free" carrier transit from inside to outside

138 The studies revealed unliganded full-length gp120 to be considerably more dyn

139 dels of predominant solution conformation of unliganded full-length Myo1c and Myo1c bound to Neph1 we

140 ti-CD4i MAbs, including MAb 21c, which bound unliganded, full-length gp120 held in a constrained conf

141 Superposition of this unliganded GAF-A with the previously reported NMR struct

142 Comparison of the unliganded GAF-B of PDE2A (215-900) with previous struct

143 y mutations of these prolines with regard to unliganded gating (DeltaG0) and the affinity change for

144 ng equilibrium constant only by changing the unliganded gating equilibrium constant (E(0)) and did no

145 The unliganded gating equilibrium constant is smaller and le

146 Knowing both the di- and unliganded gating equilibrium constants (E(2) and E(0))

147 steric" cycle as follows: diliganded gating, unliganded gating, dissociation from the C(losed) confor

148 We find that the small domain of unliganded GCK is intrinsically disordered and samples a

149 proteolysis, we map the site of disorder in unliganded GCK to a 30-residue active-site loop that clo

150 changes proposed from previous structures of unliganded GlpG.

151 loop and quaternary interactions restraining unliganded gp120 from "snapping" into this conformation.

152 extraordinary reduction in entropy, neither unliganded gp120 nor free CD4 was substantially unstruct

153 contribute to the noncovalent association of unliganded gp120 with gp41.

154 ence suggests are proximal to the V3 loop in unliganded gp120, also resulted in decreased gp120-gp41

155 he sampling of the CD4-bound conformation by unliganded gp120.

156 We show that unliganded gp140 trimers adopt a quaternary arrangement

157 cells, we observed that beta-arrestin-1 and unliganded GR interact in the cytoplasm and that, follow

158 catenin binding partners, indicating that an unliganded groove is absolutely required for an orientat

159 Unliganded H2-Q10 adopted a classical MHC-I fold and pos

160 putational methods to distinguish individual unliganded HA trimers from those that have bound C179 an

161 tabilizing its open state and the opening of unliganded HCN1, which occurs as though already disinhib

162 strate here that in epidermal keratinocytes, unliganded heterodimers of vitamin D receptor (VDR)/RXR-

163 found moderate levels of PAG associated with unliganded HIV-1 and SIV virions incubated with the thre

164 Our observations revealed unliganded HIV-1 Env to be intrinsically dynamic, transi

165 How does unliganded HIV-1 maintain CD4-binding capacity and regul

166 Notably, all of these unliganded HIV-1 structures resembled the CD4-bound stat

167 e beta/alpha-barrel structures with those of unliganded HMGCL and R41M reveals substantial difference

168 Here we report the structure of an unliganded human Fzd5 determined by single-particle cryo

169 Here we report the 2.6A crystal structure of unliganded human SC (hSC) and comparisons with a 1.7A st

170 FbpA, including one in which the protein was unliganded (i.e., apoFbpA) and one in which the protein

171 conformation between the IDE-ATP complex and unliganded IDE, but regions of the active site and C-ter

172 ed at the heterotetrameric interfaces in the unliganded IDH hetero-octamer are reduced in the ligand-

173 lin bound that allows direct comparison with unliganded IR and suggests a mechanism by which ligand r

174 Unliganded L5* VL domains crystallize as a similar antip

175 We show that unliganded LEP-R displays significant flexibility in a h

176 d structure, we report two structures of the unliganded light chain with and without the Zn(II) cofac

177 The two unliganded lobes present a canonical open conformation a

178 rier complex requires a higher proportion of unliganded low-affinity inside sites (proportional, vari

179 n crystals, the liganded (high-affinity) and unliganded (low-affinity) conformations differ in orient

180 hat 1) the Fab-Fc or Fab-Fab interactions in unliganded mAbs are retained in digested products, and 2

181 ding insights into the ATPase stimulation by unliganded MalE.

182 In X-ray solution structures, the CARDs in unliganded MDA5 are flexible, and RNA binds on one side

183 lasmic reticulum (ER) contains a pool of two unliganded MR1 conformers stabilized via interactions wi

184 mical and structural studies reveal that the unliganded, multidomain cIAP1 sequesters the RING domain

185 eased probability for phosphorylation of the unliganded mutant dimers.

186 tation alters ectodomain structure such that unliganded mutant EGFR adopts an extended, dimerization-

187 g NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3.

188 leading to the loosening of a flap, which in unliganded NMT structures, occludes the protein substrat

189 his complex bound with GAG analogues, and of unliganded Norrin and Fz4CRD.

190 on, NTS1-7m bound to NT was more stable than unliganded NTS1-7m.

191 nscriptional repression of cellular genes by unliganded nuclear receptors.

192 etrahedral oxydianions, which bind weakly to unliganded OMPDC and tightly to the enzyme-transition st

193 Here, we use PRE to study the unliganded open-closed transition of another PBP: glutam

194 rably larger than DHEA, can bind only to the unliganded (open) enzyme, whereas DHEA binds both the op

195 me), could be appropriately explained by the unliganded, open crystal structure in that it both yield

196 to conventional ligand-gated channels (e.g. unliganded openings and constitutive mutations).

197 d drugs, the lack of a BmrR structure in its unliganded or apo (DNA free and drug free) state hinders

198 there are several structures of Nei enzymes unliganded or bound to an abasic (apurinic or apyrimidin

199 t be coupled to intracellular asymmetry with unliganded partners favoring the activator kinase positi

200 They also suggest possible actions of the unliganded (passive) gating ring or added short tails on

201 Crystal structures of unliganded PGT121, 10-1074, and their likely germ-line p

202 ned from small angle x-ray scattering of the unliganded PimA and the PimA.GDP complexed forms clearly

203 We propose that unliganded PLC-beta exists in equilibrium between a clos

204 omains relative to their orientations in the unliganded polymerase structure.

205 nd negated RANTES induction, suggesting that unliganded PPARgamma is obligatory for NF-kappaB signali

206 end point of IFN activation, indicating that unliganded PR alone could decrease transcription of ISGs

207 In summary, unliganded PR-B enhanced proliferative responses to estr

208 enome-wide microarray analyses revealed that unliganded PR-B induced robust expression of a subset of

209 In contrast, unliganded PRA paradoxically activates Cx43 transcriptio

210 Moreover, unliganded PRB but not PRA enhanced FAK Tyr397 phosphory

211 Surprisingly, unliganded PRB but not PRA strongly enhanced cell migrat

212 ibrium molecular dynamics trajectory for the unliganded PreTS.

213 s, Mg(2+) replaced three Ca(2+) sites in the unliganded Protein C or APC.

214 e stability of hemoglobin concluded that the unliganded protein is only stable in the T state when a

215 most bound-like conformation in ensembles of unliganded protein structures and providing input for fr

216 ntegral component of secretory Abs, or as an unliganded protein that can mediate interactions with ba

217 t to be detectable from the structure of the unliganded protein, even when substantial conformational

218 conformational free energy landscape of the unliganded proteins.

219 Hence, gene repression mediated by the unliganded RARgamma2-co-repressor complex constitutes a

220 Comparison of Ca(2+)-bound and unliganded RCK domains suggests a physical mechanism for

221 ilon-methionine and obtained HSQC spectra of unliganded receptor as well as receptor bound to an inve

222 We report here an unliganded receptor structure in the common gamma-chain

223 epends on both the intrinsic tendency of the unliganded receptor to open and the amount of agonist bi

224 reveal the presence of a minor population of unliganded receptor, with the signature outward TM6 disp

225 four different conformational states for the unliganded receptor.

226 showed a ratio that was identical to that of unliganded receptors, agonist-bound D2 receptor-ligand c

227 imes for binding and the spatial gradient of unliganded receptors.

228 We propose that the maintenance of unliganded RNF146 in an inactive state may serve to main

229 previously, flavonoids also bind directly to unliganded rod opsin, enhancing its folding, stability,

230 They bind to and stabilize unliganded rod opsin, which in excess accelerates degene

231 ing pocket, which was previously observed in unliganded RT, is dramatically suppressed by efavirenz.

232 port the room temperature X-ray structure of unliganded SARS-CoV-2 3CL M(pro), revealing the ligand-f

233 Co-adaptation involves trafficking of unliganded sensors between the surface membrane and recy

234 The Glu-202 side chain of unliganded SP-A extends out into the solvent and away fr

235 Comparison of these complexes with the unliganded SP-A neck and carbohydrate recognition domain

236 The apo-cluster encompasses unliganded species and complexes with nonpeptidic ligand

237 A comparison of all 28 subunits of the unliganded species with the peptidic liganded forms demo

238 Comparison with its unliganded state (3.0 angstrom) reveals conformational r

239 nooxygenase, stachydrine demethylase, in the unliganded state (at 1.6 A resolution) and in the produc

240 arently affect the relative stability of the unliganded state and CD4-induced conformations.

241 Env proteins are kinetically trapped in the unliganded state and require the drug to negotiate CD4-i

242 ontribute to gp120-trimer association in the unliganded state and to CD4 binding.

243 diverse conformations that make up the gp120 unliganded state are reasonably ordered.

244 g cavity of CD1a is largely preserved in the unliganded state because of persistent electrostatic int

245 ontribute to gp120-trimer association in the unliganded state but also help secure CD4 binding.

246 ane envelope glycoprotein that stabilize the unliganded state by modulating the transitions from the

247 v to change conformation from the metastable unliganded state in response to the binding of ligands (

248 the overall shape of ct-AChBP in the apo or unliganded state is similar to that of homologues with k

249 ciency virus (SIV) must be maintained in the unliganded state of the envelope glycoprotein trimer.

250 1 has the ability to pass through its GDP or unliganded state prior to being GTP-loaded.

251 d roughly 20-fold more rapid exchange in the unliganded state than regions of low diversity (outer do

252 gp120 and regulates Env transitions from the unliganded state to downstream conformations.IMPORTANCE

253 state by modulating the transitions from the unliganded state to the CD4-bound state.

254 v conformational changes from the metastable unliganded state to the fusion-active state.

255 in decreased gp120-gp41 association (in the unliganded state) and decreased chemokine receptor bindi

256 rimeric Env displayed on native HIV-1 in the unliganded state, in complex with the broadly neutralizi

257 istic insights into the metastability of the unliganded state, receptor-induced conformational change

258 tes HIV-1 entry by rearranging from a mature unliganded state, through receptor-bound intermediates,

259 ylated HIV-1 Env trimer in its uncleaved and unliganded state.

260 d loop samples multiple conformations in the unliganded state.

261 ut maintain the extended conformation in the unliganded state.

262 presents the first structure of HDAC8 in the unliganded state.

263 the efficiency with which Env moved from the unliganded state.

264 th the cytoplasm and nucleus that stabilizes unliganded steroid receptors, controls the catalytic act

265 One loop is flexible in the unliganded structure but observed in the presence of sul

266 chanism of control involving deformations in unliganded structure from a functionally critical state

267 on where a region that was disordered in the unliganded structure is now observed in the active site

268 Here we report the first, to our knowledge, unliganded structure of EBOV GP, and high-resolution com

269 In addition to an unliganded structure solved using selenomethionyl single

270 of a GAF domain for which both liganded and unliganded structures are known.

271 or the ligand-bound sugar SBPs, but very few unliganded structures are reported.

272 ximab; however, unlike Cetuximab, one of the unliganded structures in S25-26 shows significant order

273 Applications to unliganded structures of 15 PPI target proteins show tha

274 lex at a resolution of 2.1 A, as well as the unliganded structures of D8 and LA5-Fab at resolutions o

275 ) and murine PlxnA2(1-4)-Sema6A(ecto)), plus unliganded structures of PlxnA2(1-4) and Sema6A(ecto).

276 mGluR2/7 shows cooperativity in which an unliganded subunit greatly enhances activation by agonis

277 by difficulties in the production of stable, unliganded target proteins.

278 tal structure of the catalytic domain of the unliganded TbrPDEB1 and its use for the in silico screen

279 The unliganded TbrPDEB1 X-ray structure was subjected to a s

280 stid PDECs and the crystal structures of the unliganded TcrPDEC1 catalytic domain and its complex wit

281 The unliganded tetrameric Hb S has axial and lateral contact

282 When unliganded, the CSD inhibits hyperpolarization-dependent

283 g a simple two-state transition from an open-unliganded to closed-liganded state during the transport

284 The transition from the unliganded to the CD4-bound state is regulated by two po

285 nce and presence of hormone, suggesting that unliganded TR engagement with repressive complexes on ch

286 In this model, the unliganded TR forms stable, chromatin-bound complexes wi

287 er examine NCoR1's role in repression by the unliganded TR, we deleted NCoR1 in the livers of euthyro

288 aling that can be worsened by an increase in unliganded TRalpha.

289 bility of developing selective modulators of unliganded transcription factors to dial out adverse eff

290 outward movement of negative charges in the unliganded transporter.

291 ion of the stability of the V3 pocket in the unliganded trimer or disruption of favorable V3/pocket i

292 o quaternary interactions that stabilize the unliganded trimer.

293 when CD4-liganded gp120 was compared to CD4-unliganded trimeric envelope structures.

294 angement similar to that displayed by native unliganded trimers on the surface of intact HIV-1 virion

295 erative pathways and a new pathway involving unliganded TrkA and transcriptional regulation of the pr

296 apidly on CD4-liganded virions and slowly on unliganded virions, although both reached similar levels

297 er for the ligand-bound mutants than for the unliganded wild-type channel.

298 n retained the monomer-to-dimer ratio of the unliganded wild-type TNFR1 but exhibited no ligand bindi

299 Structural comparison with unliganded, wild type RGS2 and of other RGS domain/Galph

300 nded CAP containing a D138L mutation and the unliganded WT CAP were determined at 2.3 and 3.6 A resol