ライフサイエンスコーパス: unmethylated

1 gnal amplification when they are unmodified (unmethylated).

2 sults suggest that the Ae. aegypti genome is unmethylated.

3 line where lytic viral promoters are largely unmethylated.

4 ently catalyze C2 methylation if the site is unmethylated.

5 , in D2 embryos the transgene is essentially unmethylated.

6 possibility that Dnmt2-only genomes might be unmethylated.

7 ch lytic viral gene promoters remain largely unmethylated.

8 dues within CpGs and those that were largely unmethylated.

9 d CpG islands show a strong preference to be unmethylated.

10 le promoters in IDH1/2 mutant cancers remain unmethylated.

11 in exon definition, but only when Lys-77 is unmethylated.

12 A methylation between generations and remain unmethylated.

13 d that only transformed cells contained some unmethylated 12S rRNA transcripts, with all detectable 1

14 r IFIT1, IFN-responsive genes that recognize unmethylated 2'-O RNA, resulted in restored replication

15 hree C5-methylated cytosine residues and one unmethylated 5'-CG-3' site.

16 ter, located in an intron of the neighboring unmethylated Aire gene.

17 onfirmed in vivo binding of Rex1 only to the unmethylated allele of these two regions.

18 show that CTCF binds to both methylated and unmethylated alleles of the KvDMR.

19 , and H4K91ac enrichment was specific to the unmethylated alleles.

20 e annotations associated with genes uniquely unmethylated among those with PTSD.

21 al for selectivity and stabilization, as the unmethylated analogue, mesoporphyrin IX, does not stabil

22 Nucleosomes reconstituted on an unmethylated and a methylated DNA both exhibit dynamic c

23 he approximately 70-repeat allele (which was unmethylated and associated with upregulation of C9orf72

24 most DNA methyltransferases operate at both unmethylated and hemi-methylated sites, BcgI methyltrans

25 design allows activity measurements on both unmethylated and hemimethylated DNA substrates.

26 preference for mCpG as compared to mismatch, unmethylated and hydroxymethylated DNA.

27 Then unmethylated and methylated complementary target ssDNA w

28 te the interaction between Dipyridamole with unmethylated and methylated cytosine.

29 ich significantly interacted with hybridized unmethylated and methylated DNA.

30 CP2) when free in solution and when bound to unmethylated and methylated DNA.

31 toimmune hepatitis exhibited lower levels of unmethylated and methylated INS compared with subjects w

32 that absolute levels (rather than ratios) of unmethylated and methylated INS DNA differ between subje

33 sed droplet digital PCR to measure levels of unmethylated and methylated INS DNA in serum from subjec

34 Our study shows that elevations in both unmethylated and methylated INS DNA occurs in new-onset

35 At 1 year postonset, both unmethylated and methylated INS DNA returned to control

36 mpared with control subjects, levels of both unmethylated and methylated INS DNA were elevated at T1D

37 tional differences were observed between the unmethylated and methylated nucleosomes.

38 Upon the addition of the target unmethylated and methylated ssDNA, the fluorescence inte

39 The compactness of both unmethylated and methylated tetra-nucleosomes is depende

40 on of CTCF binding loss in DKO ESCs, whereas unmethylated and nucleosome-depleted CpG islands were en

41 and several prosurvival lymphoma genes were unmethylated and overexpressed.

42 The difference between the unmethylated and the methylated nucleosome persists with

43 FadE uses SBT unmethylated and untreated data to determine background

44 ngly, in both patients and controls, DNA was unmethylated at a CpG island in PR3, whereas in healthy

45 domain (ARD) as a reader of histone H4 tails unmethylated at K20 (H4K20me0), which are specific to ne

46 ule that specifically binds histone H3 tails unmethylated at K4 and R2 and acetylated at two key lysi

47 cruitment requires recognition of histone H4 unmethylated at lysine 20 (H4K20me0), linking DSB repair

48 ion enzyme (restriction glycosylase) excises unmethylated bases from its recognition sequence.

49 The transgene DNA fragment was unmethylated before it was injected into the pronucleus,

50 on1A within a potential CpG island, which is unmethylated both in cell lines and in primary lymphoma

51 drated membranes containing trimethylated or unmethylated bovine c8-rings and bacterial c10- or c11-r

52 In addition, FDM1 binds unmethylated but not methylated DNAs through its coiled-

53 ressed precisely when the neighboring CGI is unmethylated but remain silenced otherwise.

54 peri-tumoral lung tissues in which SOX30 was unmethylated, but was silenced or downregulated in lung

55 unoxidized C, rather than methylated C from unmethylated C.

56 DNA rich in unmethylated CG motifs (CpGs) engage Toll-Like Receptor

57 sociated Tremor Ataxia Syndrome, result from unmethylated CGG repeat expansions in the 5' untranslate

58 data also show that GC skew is predictive of unmethylated CGI promoters in a range of vertebrate spec

59 CRA gene enhancer (Ealpha) is in an open and unmethylated chromatin structure well before activation.

60 egrates sequencing reads from methylated and unmethylated compartments and estimates CpG methylation

61 es were retained in the wells, distinct from unmethylated complexes.

62 ed CpG sites to current levels obtained with unmethylated copies of the DNA reveals the precise locat

63 were predictive of 5-hmC changes, suggesting unmethylated CpG and H3K4me2 as potential upstream signa

64 Thus, CXXC5 as an unmethylated CpG binder contributes to E2-mediated gene

65 recombinant protein that CXXC5 is indeed an unmethylated CpG binder.

66 roducts such as lipopolysaccharide (LPS) and unmethylated CpG containing DNA to the liver via the por

67 holera toxin, E. coli labile toxin (LT), and unmethylated CpG dinucleotide (CpG).

68 G antibodies develop in humans against short unmethylated CpG dinucleotide sequences after administra

69 , our results suggest that a high density of unmethylated CpG dinucleotides is sufficient for vertebr

70 member of the ZF-CXXC family, which binds to unmethylated CpG dinucleotides of DNA and through enzyma

71 X CXXC domain binds DNA sequences containing unmethylated CpG dinucleotides, localizes to promoters a

72 n the CXXC3 domain of Mbd1, which recognizes unmethylated CpG dinucleotides.

73 ft changes between binding to methylated and unmethylated CpG dinucleotides.

74 Exposure of humans or mice to unmethylated CpG DNA (CpG) from bacteria reproduces thes

75 TLR9 recognizes unmethylated CpG DNA and induces innate immune responses

76 Toll-like receptor 9 (TLR9) recognizes unmethylated CpG DNA and is activated by fungal DNA.

77 and KDM2B, which helps target the complex to unmethylated CpG DNA islands, are required for optimal T

78 Unmethylated CpG DNA signals through TLR9 to induce type

79 Bacterial components, such as unmethylated CpG DNA, a Toll-like receptor (TLR) 9 agoni

80 h a hyper-accessible state characteristic of unmethylated CpG island promoters.

81 ed by the preferential binding of TET1-FL to unmethylated CpG islands (CGIs) through its CXXC domain.

82 ET1 (TET1FL) has a CXXC domain that binds to unmethylated CpG islands (CGIs).

83 ated with exons as compared to introns while unmethylated CpG islands near transcription start sites

84 H3K27me3 is unable to spread from large unmethylated CpG islands, while H3K27me2 can be deposite

85 ment with an oligodeoxynucleotide containing unmethylated CpG motif (CpG-ODN) and alanyl-glutamine in

86 x structure, which specifically binds to the unmethylated CpG motif but in a completely different man

87 Oligodeoxynucleotides containing unmethylated CpG motifs act as ligands of Toll-like rece

88 Activation of TLR9 by direct injection of unmethylated CpG nucleotides into a tumor can induce a t

89 on of the TLR4 ligand LPS or the TLR9 ligand unmethylated CpG oligodeoxynucleotide before transient b

90 K plays an essential role in DC responses to unmethylated CpG oligodeoxynucleotide: although response

91 ntact sensitization and by adjuvants such as unmethylated CpG oligonucleotide (CpG) and LPS that indu

92 receptor, TLR9, which signals in response to unmethylated CpG sequences in microbial DNA.

93 nthetic DNA probes that target methylated or unmethylated CpG sites in the MSP amplicon, and measures

94 gonucleotide with one hemimethylated and two unmethylated CpG sites, which are also recognition sites

95 ltransferase domains bound to DNA-containing unmethylated CpG sites.

96 Temporal changes of H3K4me2, unmethylated CpG, and H2A.Z were predictive of 5-hmC cha

97 Most vertebrate promoters lie in unmethylated CpG-dense islands, whereas methylation of t

98 During bacterial and viral infections, unmethylated CpG-DNA released by proliferating and dying

99 t form during transcription, especially over unmethylated CpG-rich promoters of active genes.

100 ay a bimodal distribution with enrichment of unmethylated CpGs and depletion of fully methylated CpGs

101 CxxC finger protein 1 (Cfp1), which binds to unmethylated CpGs and links H3K4me3 with CpG islands (CG

102 nzyme is a cost-effective method to pinpoint unmethylated CpGs at single base-pair resolution.

103 abnormal methylation of a subset of normally unmethylated CpGs, a characteristic of the CpG island me

104 ophils, showed a euchromatic CD177 promoter, unmethylated CpGs, and c-Jun and c-Fos binding.

105 Grouping unmethylated CpGs, characterized by high MSCC scores (7%

106 ronger localization to methylated as well as unmethylated CpGs.

107 drome tumors with MSH2 methylation than MSH2-unmethylated CRCs.

108 lfite conversion technique (i.e., converting unmethylated Cs to Us and then to Ts after PCR amplifica

109 risation in normal cells (CTCF binds to both unmethylated CTCF-BS3 and CTCF-BS2).

110 Oligodeoxynucleotides containing unmethylated cytidyl guanosyl dinucleotide motifs (CpG O

111 ion to accurately estimate the parameters of unmethylated cytosine (5C), 5mC and 5hmC from Infinium m

112 Intratumoral injection of an unmethylated cytosine guanine dinucleotide (CpG)-enriche

113 In contrast, the unmethylated cytosine's exocyclic N4 amino group (NH2) a

114 70 pM) in the presence of human stimulatory unmethylated cytosine-guanine-rich DNA A (hCpGAs).

115 lizes to methylated and, to a lesser degree, unmethylated cytosine-guanosine dinucleotides (CpGs), ye

116 In contrast, mouse macrophages contain unmethylated cytosine-phosphate-guanine (CpG) dinucleoti

117 The dimerization is facilitated by unmethylated cytosine-phosphate-guanine (CpG) DNA as wel

118 TLR9 recognizes unmethylated cytosine-phosphate-guanine (CpG) motifs pre

119 Normal B cells can be activated by specific unmethylated cytosine-phosphate-guanosine (CpG) DNA moti

120 n of base-excision repair machinery restores unmethylated cytosine.

121 ision repair pathway that finally inserts an unmethylated cytosine.

122 ethylated (5hmC) state and do not resolve to unmethylated cytosine.

123 hidden Markov model to distinguish 5-mC from unmethylated cytosine.

124 r one could explain the E446D preference for unmethylated cytosine.

125 ligodeoxynucleotide CpG 7909, which contains unmethylated cytosine/guanine (CpG) motifs, has potent i

126 ted cytosines over the sum of methylated and unmethylated cytosines at position 5 (%5mC)] varied acro

127 Incomplete conversion of unmethylated cytosines can introduce false positive meth

128 of the key steps in the assay is converting unmethylated cytosines into thymines (BS conversion).

129 esses resulting in replacement of 5meCs with unmethylated cytosines is a hallmark of primordial germ

130 Unmethylated cytosines may be converted to uracil throug

131 Sodium bisulfite treatment (SBT) causes unmethylated cytosines to be sequenced as thymine, which

132 ted cytosines deaminate at higher rates than unmethylated cytosines, and the lesions they produce are

133 ges, whereas lipoteichoic acid and synthetic unmethylated deoxycytidine-deoxyguanosine dinucleotides,

134 odeoxyribonucleotides (ODNs) containing CpG (unmethylated deoxycytidylyl-deoxyguanosine dinucleotide)

135 y EP300 in the bodies of expressed genes are unmethylated despite the dense gene-body methylation sur

136 Although the Npas2 promoter remains largely unmethylated, differential Npas2 promoter occupancy of a

137 ons (177-plex) using dilutions of methylated/unmethylated DNA and in DNA from clinical lung cancer sa

138 T1, and CGBP CXXC domains could each bind to unmethylated DNA but with differing affinity.

139 ermore, the discrimination of methylated and unmethylated DNA is demonstrated in the presence of only

140 sform C. jejuni, whereas otherwise identical unmethylated DNA is not.

141 he endonuclease reaction of these enzymes on unmethylated DNA is preceded by bidirectional translocat

142 specific binding activity to methylated and unmethylated DNA motifs of distinct sequences.

143 y is sensitive to distinguish methylated and unmethylated DNA sequences at single CpG resolution by d

144 M enzymes need to interact with two separate unmethylated DNA sequences in inversely repeated head-to

145 ce with respect to relative adsorption of an unmethylated DNA source and this was detected using surf

146 While the two proteins bound unmethylated DNA with indistinguishable affinity, their

147 When MeCP2 binds to unmethylated DNA, H/DX is slowed several orders of magni

148 D3 MBD on hydroxymethylated, methylated, and unmethylated DNA.

149 fic endonuclease that cleaves methylated and unmethylated DNA.

150 crease in ionic blockage current relative to unmethylated DNA.

151 in the specificity for hemimethylated versus unmethylated DNA.

152 trodes in comparison to the adenine-enriched unmethylated DNA.

153 onstrate that EcoKI becomes unstable on long unmethylated DNA; reuse of the methyltransferase subunit

154 ted in exhausted CD8(+) T cells and remained unmethylated even when virus titers decreased.

155 a level between that of fully methylated and unmethylated exons, highlighting gene context-dependent

156 Unmethylated, expressed HNF1B, primarily present in clea

157 ted host DNA and an endonuclease function on unmethylated foreign DNA.

158 MJD2A on the latent genome maintains H3K9 in unmethylated form and signals the readiness of specific

159 These results suggest that the unmethylated form of the EBV genome can undergo viral re

160 conversion of 5-methyl-cytosine back to the unmethylated form, the data were consistent with the use

161 The methylated and unmethylated forms of an oriLyt-containing plasmid repli

162 tients With Newly Diagnosed Glioblastoma and Unmethylated Gene Promoter Status; NCT00813943), and Rad

163 We identify 355 and 333 uniquely unmethylated genes in Dnmt3a and Dnmt3b knockout (KO) 2i

164 genes and had slower evolutionary rates than unmethylated genes, suggesting that WGD genes evolve mor

165 ave been reported to evolve more slowly than unmethylated genes.

166 Methylated genes evolve faster than unmethylated genes; DNA methylation changes between homo

167 ethylation establishment occurs on a largely unmethylated genome and in nondividing cells, making it

168 lular differentiation in organisms that have unmethylated genomes (such as Caenorhaditis elegans and

169 een organisms that have either methylated or unmethylated genomes, DNA methylation endows genomes wit

170 generally unavailable to organisms that have unmethylated genomes.

171 ion, smtB repression significantly increased unmethylated GlcCer levels and compromised filamentous g

172 Although increased levels of unmethylated GlcCer were observed in smtA and smtB mutan

173 that DeltasdeA accumulated C8-saturated and unmethylated GlcCer, while gcsA deletion impaired GlcCer

174 Three patients with MGMT unmethylated glioblastoma multiforme survived 6.5, 8.7,

175 fully methylated, partially methylated, and unmethylated groups, profiling the average DNA methylati

176 robes selective for methylation-specific and unmethylated GSTP1 sequences were immobilized onto the s

177 G-rich strands, with a binding preference of unmethylated > 5hmCpG > 5mCpG, where methylated DNA-prot

178 ne mutants that mimicked the conformation of unmethylated H3 K79 increased the rate of silencing esta

179 erence for substrates with less methylation [unmethylated H3K27 (H3K27me0):me1:me2 k(cat)/K(m) ratio

180 show that the PHD1 preferentially recognizes unmethylated H3K4 histone tail, product of KDM5A-mediate

181 lve the methylation status of CpG dyads into unmethylated, hemi-methylated, and methylated.

182 s able to predict the relative abundances of unmethylated, hemimethylated, fully methylated, and hydr

183 osition nearly identical to the N(3) atom of unmethylated histidine.

184 antly inhibited by stoichiometric amounts of unmethylated histone H3, but not by histones previously

185 ough its ability to bind both methylated and unmethylated histone residues.

186 teraction between Dnmt3-ADD domain with H3K4 unmethylated histone tails that is disrupted by histone

187 stablish the histone code on newly assembled unmethylated histones and thus may act as epigenetic mar

188 However, it has been suggested that the unmethylated IG-DMR acts as a positive regulator activat

189 lize to Polycomb group target genes that are unmethylated in 11 different fetal tissue types, we show

190 ry regions, which were specifically open and unmethylated in basal-like breast cancer.

191 s in the starting coding region were largely unmethylated in both groups.

192 glioma stem cells (GSC) and glioma cells but unmethylated in CD133+ve ones.

193 Surprisingly, the PD-1 promoter remained unmethylated in HIV-specific CD8 T cells from subjects w

194 In contrast, CpCpG sites remain unmethylated in IBM1-independent genes and do not promot

195 d that the insulin gene promoter is uniquely unmethylated in insulin-expressing pancreatic beta-cells

196 Promoter CpG islands are typically unmethylated in normal cells, but in cancer a proportion

197 bisulfite genome sequencing; whereas, it was unmethylated in normal cervical tissues (p < 0.05).

198 egion that is highly methylated in sperm but unmethylated in oocytes.

199 We also found that the SAMHD1 promoter is unmethylated in primary CD4(+) T lymphocytes, which expr

200 pes were in a permissive chromatin state and unmethylated in RPE.

201 at the transcriptional regulatory region was unmethylated in the PD-1(hi) HIV-specific CD8 T cells, w

202 an overlapping Pol II transcript and remain unmethylated in the presence of trans-acting 24-nt siRNA

203 tional regulatory region continued to remain unmethylated in these donor CD8 T cells generated from a

204 in secretion, indicating that the changes in unmethylated INS DNA are indicative of beta cell killing

205 t, methylated INS DNA remained elevated, but unmethylated INS DNA fell.

206 a-cell death by measuring relative levels of unmethylated INS DNA in serum and used it to measure bet

207 althy controls and higher than the levels of unmethylated INS DNA in the at-risk progressor and at-ri

208 We conclude that a blood test that measures unmethylated INS DNA serves as a marker of active beta c

209 who progressed to T1D had average levels of unmethylated INS DNA that were elevated modestly compare

210 Subjects at high risk for T1D had levels of unmethylated INS DNA that were higher than those of heal

211 progressed to T1D, the observed increases in unmethylated INS DNA were associated with decreases in i

212 ethylated TNFA promoter when compared to the unmethylated insert (P = 0.03).

213 with an assay that detects beta cell-derived unmethylated insulin (INS) DNA.

214 intensities or (iii) combined methylated and unmethylated intensities.

215 ns as a dual lysine reader, probing for both unmethylated K4 and methylated K9 modifications on the h

216 rrow binding pocket to selectively recognize unmethylated K4 of histone H3.

217 In backcrosses to an unmethylated Ler allele, the newly methylated F1 Ler seg

218 t to At3g43340 and At3g43350, the originally unmethylated Ler genomic segment receives the C24 (m)C p

219 Furthermore, serum unmethylated LINE-1 was at higher levels in both stage I

220 er-related phenotypes than miRNAs encoded by unmethylated loci.

221 old selectivity in covalent labeling over an unmethylated lysine peptide.

222 ifferentially methylated region (DMR) on the unmethylated maternal allele.

223 producible and clearly discriminated between unmethylated, methylated and even partially methylated D

224 The ratio of the unmethylated/methylated KLOTHO promoter DNA did not chan

225 results offer an explanation for how and why unmethylated microsatellite repeats can be destabilized

226 in enrichment of the targeted methylated or unmethylated minority-epigenetic-alleles.

227 onstrate that HESO1 is an enzyme uridylating unmethylated miRNAs and siRNAs in hen1.

228 lso suggest that uridylation may destabilize unmethylated miRNAs through an unknown mechanism and com

229 However, enzymes uridylating unmethylated miRNAs, siRNAs, or piRNAs in hen1 are unkno

230 ltaT(m)'s for serial dilutions of methylated:unmethylated mixtures allows for quantification of methy

231 e accomplished include the discrimination of unmethylated, mono-, di-, and trimethylated lysines on a

232 rthermore, KLF4 binds specific methylated or unmethylated motifs in human embryonic stem cells in viv

233 Capped but unmethylated mRNAs generated in yeast cells with a defec

234 Patients with unmethylated O(6)-methylguanine-DNA methyltransferase (M

235 gh expression of hepatocyte growth factor or unmethylated O(6)-methylguanine-DNA methyltransferase ma

236 n individual DNA molecules, we show that the unmethylated OCT4 distal enhancer has an NDR, whereas NA

237 y shift assays revealed increased binding of unmethylated oligos with nucleoproteins of cells maintai

238 nt homeodomain (PHD(4-6)) of MLL4 recognizes unmethylated or asymmetrically dimethylated histone H4 A

239 chromatin state, but these promoters were in unmethylated or low-methylated regions.

240 ong known to exist in two functional states: unmethylated or methylated at the 5-position of the pyri

241 se results suggest that MBD2 targets NuRD to unmethylated or methylated CpG islands where its distinc

242 f human DNA and 668 KB of mouse DNA that was unmethylated or methylated in order to investigate the e

243 e versa (1425.1 for methylated vs 1828.0 for unmethylated; P < .001).

244 ed regions, with preferential binding to the unmethylated parental allele.

245 n precise inheritance of both methylated and unmethylated parental alleles.

246 The Kcnq1ot1 non-coding RNA emerges from the unmethylated paternal KvDMR in antisense direction, resu

247 Additionally, binding of NEAT2 to unmethylated Pc2 promotes E2F1 SUMOylation, leading to a

248 the consequence of binding of methylated and unmethylated Pc2 to the ncRNAs TUG1 and MALAT1/NEAT2, lo

249 Here we use antibodies specific for the unmethylated phosphatases to show that PP6 is carboxyl-m

250 ased on the ability of O-methylated (but not unmethylated) precursors to bypass the BioC requirement

251 rphology, implying the presence of a pool of unmethylated prenyl proteins in these cells under normal

252 f JMJD1A facilitates efficient production of unmethylated product from dimethyl-H3K9 and decreases th

253 y a full CGG repeat expansion but exhibit an unmethylated promoter and lack the FXS phenotype.

254 1 or -Dnmt3a fusion protein to methylated or unmethylated promoter sequences caused activation or sil

255 ional repressor that preferentially binds an unmethylated promoter used in the reporter assays.

256 d when considering only those tumors with an unmethylated promoter, whereas the related factor, TFAP2

257 en highly methylated repetitive elements and unmethylated promoter-CGIs in normal tissues.

258 Noninduced proviruses have unmethylated promoters and are integrated into active tr

259 to regulate transcription of methylated and unmethylated promoters in a luciferase reporter assay.

260 entially induces H3K9 histone acetylation of unmethylated promoters in vivo.

261 d to repress transcription of methylated and unmethylated promoters.

262 -methylcytosine, 5-hydroxymethylcytosine and unmethylated proportions from methylation array data.

263 This activation requires an unmethylated PWS-IC in the gametes and during early embr

264 guish between methylated (petrogenic) versus unmethylated (pyrogenic) phenanthrenes; such antibodies

265 About 50% of MSCC-defined unmethylated regions do not overlap algorithm-defined CG

266 e cytosine methylation, it is less clear how unmethylated regions in mammalian genomes are protected

267 discovery rate), we found a large number of unmethylated regions not qualifying as CGIs located in i

268 lled restriction sites, whereas R recognizes unmethylated restriction sites as non-self and introduce

269 AtLSMT-L is able to interact with unmethylated Rubisco, but the complex is catalytically u

270 Oligonucleotide probes targeting unmethylated sequences generate local double stranded re

271 re, tethering SUVH2 with a zinc finger to an unmethylated site is sufficient to recruit Pol V and est

272 almost all Type IIB systems, BcgI needs two unmethylated sites for nuclease activity; it cuts both s

273 effect on the binding affinity of SP1 to the unmethylated sites in H9c2 cells, hearts of fetuses and

274 d target DNA methylation de novo at normally unmethylated sites in the genomes of root cells from a d

275 ot distinguish between hydroxymethylated and unmethylated sites.

276 moter was observed under HG, especially with unmethylated Sp-1 oligo.

277 ncreased in linear range by concentration of unmethylated ssDNA from 1.6 x 10(-15) to 6.6 x 10(-13)M

278 pendent on preservation of the methylated or unmethylated state and the type of sequence.

279 ial is correlated with and predictive of the unmethylated state of CGIs.

280 maintaining the transcriptionally active and unmethylated state of CpG island promoters.

281 tly, how sequence architecture mediates this unmethylated state remains unclear.

282 A hallmark of CpG islands is their unmethylated state, and determining how DNA methylation

283 ensity alone is a minor determinant of their unmethylated state.

284 ent conversion of dimethylated H3K9 into the unmethylated state.

285 designed new tools to compare methylated and unmethylated structural profiles of TFs and methods to d

286 We show that PRMT5-MEP50 prefers unmethylated substrates, consistent with a distributive

287 ATPase stimulation by hemimethylated versus unmethylated substrates.

288 ess 60-fold higher ISG15 compared with SULF2 unmethylated (SULF2U) NSCLC cell lines and normal human

289 he PP2A catalytic subunit, selective for the unmethylated tail and perturbing/inactivating the phosph

290 We analyzed its association with an unmethylated target site on fluorescence-labeled DNA in

291 e stranded regions resulting to digestion of unmethylated targets, and leaving methylated targets int

292 Unmethylated THOR repressed TERT promoter activity regar

293 istal regulatory elements are constitutively unmethylated throughout T cell differentiation, irrespec

294 However, 27 GANTC sites remained unmethylated throughout the cell cycle, suggesting that

295 mostly in vitro to in vivo binding and from unmethylated to methylated DNA.

296 Elevated ratios of circulating unmethylated to methylated preproinsulin (INS) DNA have

297 iched with CpG sites, are hypomethylated and unmethylated under HG ambience and hyperglycemic states

298 TANCE The binding of ZEBRA to methylated and unmethylated viral DNA triggers activation of the EBV ly

299 wo distinct chromatin configurations: one is unmethylated with an NDR upstream of the TSS; another is

300 er-associated genomic regions and are mostly unmethylated within highly methylated mammalian genomes.