ライフサイエンスコーパス: unnatural

1 [3], mesocosms whose interior conditions are unnatural [4], and long-term correlation studies based o

2 We also describe the synthesis of unnatural 6-O-sulfated CS pentasaccharides containing ei

3 the apparent free energy of partitioning of unnatural aliphatic amino acids on TM segments is propor

4 nthesis of a variety of types of natural and unnatural alpha-amino acid derivatives, with a wide rang

5 Unnatural alpha-amino acids form a family of essential m

6 to characterize the challenges attendant to unnatural alpha-amino amide synthesis.

7 plex peptides, particularly those containing unnatural alpha-amino amides.

8 ons, including both a canonical beta- and an unnatural alpha-anomeric configuration.

9 The unnatural alpha-Gal and beta-Man terminating antennae ca

10 aviolet irradiation of a photo-crosslinkable unnatural amino acid (UAA) cotranslationally incorporate

11 monstrate the application of a photoreactive unnatural amino acid (UAA) crosslinking system to captur

12 Through multi-site unnatural amino acid (UAA) incorporation, these protein

13 tached to proteins within living cells using unnatural amino acid (UAA) mutagenesis.

14 echnology to site-specifically introduce the unnatural amino acid (UAA) p-azido-l-phenylalanine (azF)

15 (AMPA)-type iGluRs using genetically encoded unnatural amino acid (UAA) photocross-linkers, p-benzoyl

16 onal aaRS to distinguish between a favorable unnatural amino acid (unAA) substrate from unfavorable n

17 ne WALP24 peptide labeled with the semirigid unnatural amino acid 4-(3,3,5,5-tetra-methyl-2,6-dioxo-4

18 vancing existing protocols, we introduced an unnatural amino acid and subsequently mineral-interactin

19 CR1 (1-350) containing Mn(2+) chelated to an unnatural amino acid assists in the characterization of

20 2 substrate library, which also included the unnatural amino acid cyclohexylalanine (Cha) derivative

21 n of 3-, 4-, 5-, and 6-membered heterocyclic unnatural amino acid derivatives by exploiting facile Ma

22 nt immunosensor designed by incorporating an unnatural amino acid fluorophore into the binding site o

23 strong polarity and high hydrophobicity, the unnatural amino acid forms specific and strong interacti

24 As well, using a UV-crosslinking unnatural amino acid in KCNE1, we found EQQQQ and EQQ cr

25 arnessing proximity-enabled reactivity of an unnatural amino acid incorporated in the bait toward a t

26 Here, using unnatural amino acid incorporation and fluorine-19 nucle

27 ns and highlight the exceptional capacity of unnatural amino acid incorporation for increasing our un

28 don suppression and related technologies for unnatural amino acid incorporation has greatly expanded

29 nstituted in vitro translation, quantitative unnatural amino acid incorporation via AUG codon reassig

30 heterogeneity in GCK using a combination of unnatural amino acid incorporation, time-resolved fluore

31 pair enabling site-specific insertion of the unnatural amino acid into apoA-I.

32 Escherichia coli MS methods verify that the unnatural amino acid is only incorporated at one positio

33 Specifically, we create the pY protein by unnatural amino acid misincorporation, mutagenize a univ

34 We report a general unnatural amino acid mutagenesis approach to quantify th

35 The advent of unnatural amino acid mutagenesis opens up a new toolbox

36 ereoselective route to a masked form of this unnatural amino acid now enabled the synthesis of two of

37 For these studies, we have incorporated the unnatural amino acid p-acetyl-L-phenylalanine for specif

38 tive way to modify protein N-termini and the unnatural amino acid p-aminophenylalanine (paF).

39 The unnatural amino acid p-Benzoylphenylalanine was successf

40 Here, we have used unnatural amino acid photo-cross-linking to investigate

41 to increase the structural diversity of the unnatural amino acid pool is needed.

42 not be feasible to separate the full-length unnatural amino acid protein from the truncated form.

43 mination of a chiral center derived from the unnatural amino acid R-alpha-methylcysteine makes the mo

44 gth overlap and highly selective natural and unnatural amino acid recognition sequences.

45 Many important and useful natural and unnatural amino acid salts can be produced in excellent

46 This Perspective highlights the diversity of unnatural amino acid structures found in hit-to-lead and

47 ombination of self-labeling protein tags and unnatural amino acid technology permits the semisynthesi

48 Unnatural amino acid technology provides a degree of bio

49 he binding site of the binding protein using unnatural amino acid technology.

50 O-tert-Butyltyrosine (Tby) is an unnatural amino acid that can be site-specifically incor

51 arget protein contains a genetically encoded unnatural amino acid with bioorthogonal reactivity and t

52 ara-pentafluorosulfanyl phenylalanine, is an unnatural amino acid with extreme physicochemical proper

53 polymerase variant containing a fluorescent unnatural amino acid, (7-hydroxy-4-coumarin-yl) ethylgly

54 anted to report the utility of an unexplored unnatural amino acid, isothiocyanyl alanine ((NCS)Ala =

55 movement by incorporating tryptophan and the unnatural amino acid, p-cyanophenylalanine into Glt(Ph)

56 By imaging with fluorescent unnatural amino acid, we found that menthol binding indu

57 Using next-generation sequencing and unnatural amino acid-mediated protein-DNA cross-linking,

58 labeled enzyme are largely unaffected by the unnatural amino acid.

59 age C-H oxidation to one containing a linear unnatural amino acid.

60 Two stabilized derivatives incorporating unnatural amino acids ((68)Ga-SH01078 and (68)Ga-P03034)

61 The ability to incorporate unnatural amino acids (UAA) into proteins in a site spec

62 nsporter protein to encode photocrosslinking unnatural amino acids (UAAs) into 75 different positions

63 rm is reported that enables incorporation of unnatural amino acids (UAAs) into specific sites on the

64 fted toward site-specific modification using unnatural amino acids and engineered site-selective amin

65 plants or synthetic chemistry can introduce unnatural amino acids and non-peptidic constraints that

66 plied to the diastereoselective synthesis of unnatural amino acids and the late-stage derivatization

67 allows for straightforward incorporation of unnatural amino acids and the preparation of peptides ma

68 on the in vivo incorporation of fluorescent unnatural amino acids and their analysis by steady-state

69 Methods for installing natural and unnatural amino acids and their modifications into prote

70 thyl-14- O-methylmorphinans with natural and unnatural amino acids and three dipeptides at position 6

71 Among them, silicon-containing unnatural amino acids are becoming an interesting new cl

72 Unnatural amino acids are introduced site-specifically a

73 Unnatural amino acids are key building blocks in therape

74 r demonstrate that IQF substrates containing unnatural amino acids can be used to investigate proteas

75 sical properties of three of the fluorescent unnatural amino acids from two classes were also studied

76 ally-encoded, site-specific incorporation of unnatural amino acids in regions essential for activatio

77 nd enables the preparation of Fmoc-protected unnatural amino acids in three steps.

78 However, the efficient incorporation of unnatural amino acids into proteins and the specific, fl

79 Site-specific incorporation of unnatural amino acids into proteins provides a powerful

80 principles and methods for incorporation of unnatural amino acids into proteins.

81 bles efficient, homogeneous incorporation of unnatural amino acids into target proteins in diverse ma

82 e basis for ion selectivity by incorporating unnatural amino acids into the channel, engineering chan

83 urements, because efficient incorporation of unnatural amino acids is limited to transient expression

84 Unnatural amino acids play an important role in peptide

85 Genetically encoded unnatural amino acids provide powerful strategies for mo

86 o acids are transformed to twenty-one chiral unnatural amino acids representing seven distinct functi

87 achieved using peptide libraries containing unnatural amino acids such as the hybrid combinatorial s

88 The expression of proteins containing unnatural amino acids through suppression of a stop codo

89 In this study, we used a set of unnatural amino acids to fully map the substrate prefere

90 We genetically encoded four unnatural amino acids with a diverse set of functional g

91 y relationship for binding using a series of unnatural amino acids with different lengths of hydropho

92 The synthesis of unnatural amino acids with small side-chain functionalit

93 The synthesis of a third class of unnatural amino acids, amino tetrazolyl alanines ((ATz)A

94 the amino acid sequence, the introduction of unnatural amino acids, and labeling with stable isotopes

95 oto-cross-linking studies with site-specific unnatural amino acids, and species-specific activity of

96 or labeling through genetic incorporation of unnatural amino acids, lanthanide resonance energy trans

97 Ita), for the synthesis of another class of unnatural amino acids, thioureayl alanines ((TU)Ala = Tu

98 s-linking experiments with photo-activatable unnatural amino acids, we show that full-length BACE1, i

99 eins, and expand the genetic code to include unnatural amino acids.

100 brary (HyCoSuL), which uses both natural and unnatural amino acids.

101 n through the site-directed incorporation of unnatural amino acids.

102 photostabilizer and biomolecular target via unnatural amino acids.

103 ish eight tripeptides, each having different unnatural amino acids.

104 nalogues in which Phe(13) was substituted by unnatural amino acids.

105 Using unnatural amino-acid mutagenesis, we subtly altered the

106 , we used reconstituted 26S proteasomes with unnatural amino-acid-attached fluorophores in a series o

107 RNAs, semi-synthetic organism creation, and unnatural-amino-acid-containing protein synthesis.

108 e triphosphates enforces initiation with the unnatural analogue, yielding 5'-end modified transcripts

109 elective mutasynthesis lead to production of unnatural analogues cahuitamycins D and E of increased p

110 ng material to provide hinduchelins A-D (and unnatural analogues) in only four steps and 5-15% overal

111 s in turn enables ready access to a range of unnatural analogues, among which several compounds showe

112 tion; to study enzyme function with natural, unnatural and CF(2)-labelled post-translationally modifi

113 Both the natural d-enantiomer, and the unnatural and heretofore unknown l-enantiomer, were conv

114 Further modifications with unnatural and modified amino acids resulted in novel met

115 for all-cause mortality and for an array of unnatural and natural causes of death among patients rec

116 ray dried betanin samples were described as 'unnatural' and 'artificial' whereas the colour of beetro

117 rent unnatural codons and tRNAs with cognate unnatural anticodons, and their efficient decoding at th

118 Herein, we use two unnatural aromatic amino acids and several spectroscopic

119 The synthesis of bioinspired unnatural backbones leading to foldamers can provide eff

120 that replicate unnatural base pairs (UBPs), unnatural backbones, tags, or other evolutionarily novel

121 g., helices, sheets) have been produced from unnatural backbones, yet examples of tertiary folds comb

122 S techniques often lead to quick fatigue and unnatural ballistic movements.

123 We have developed an unnatural base pair (UBP) and a semisynthetic organism (

124 two synthetic nucleotides that form a third, unnatural base pair (UBP) have recently yielded three pr

125 semisynthetic organism (SSO) that retains an unnatural base pair (UBP) in its DNA, transcribes it int

126 s them to replicate a plasmid containing the unnatural base pair dNaM-dTPT3.

127 ino acid, and efficient participation of the unnatural base pair in decoding at the ribosome.

128 mation requires in vivo transcription of the unnatural base pair into mRNA and tRNA, aminoacylation o

129 These marker nucleotides constitute an unnatural base pair, allowing large quantities of marked

130 rs two additional letters that form a third, unnatural base pair.

131 increased information, we have developed the unnatural base pairs (UBPs) dNaM and d5SICS or dTPT3 (dN

132 Unnatural base pairs (UBPs) have been developed and used

133 ineering to identify variants that replicate unnatural base pairs (UBPs), unnatural backbones, tags,

134 Through the development of unnatural base pairs that are compatible with native DNA

135 the creation of artificial extra base pairs (unnatural base pairs, UBPs) are opening the door to a ne

136 onents provides the basis to further develop unnatural base-pairs for synthetic biology applications.

137 ini-hairpin DNA provides robust stability to unnatural-base DNA aptamers generated by SELEX using gen

138 ever, this minimal model tends to produce an unnatural behaviour where several smaller aggregates eme

139 l amino acids in place of Asn and introduces unnatural beta-thioether linkages at unactivated positio

140 ation extends the nucleophilic character to "unnatural" beta, delta, ...

141 ows for the direct formation of a variety of unnatural biaryl-containing amino acids in good to excel

142 Two unnatural bromo-chloro-malbrancheamide analogues were ge

143 of the native side chains is displayed on an unnatural building block to generate a heterogeneous bac

144 diversity of chemically plausible (including unnatural but functionally relevant) side chains is not

145 ifferently access to the natural C20-(R) and unnatural C20-(S) configurations.

146 a platform for the production of natural and unnatural cannabinoids that will allow for more rigorous

147 has always been a challenge, especially for unnatural carbohydrate motifs which do not have C2 subst

148 On the other hand, when "unnatural" carbonyl ipso-sites are activated as nucleoph

149 Unnatural cause of death represented 40.6% of fatalities

150 of child, sibling or spouse, and loss due to unnatural cause were analyzed separately (P for trend or

151 el factors for all-cause, natural-cause, and unnatural-cause mortality in those with severe mental il

152 el factors for all-cause, natural-cause, and unnatural-cause mortality in those with severe mental il

153 and sub-hazard ratios for natural-cause and unnatural-cause mortality were lower in most ethnic mino

154 30]), natural causes (3.00 [2.69-3.36]), and unnatural causes (2.10 [1.27-3.49]), compared with no hi

155 icides (7.65, 95% CI 6.43-9.04), non-suicide unnatural causes (4.01, 3.34-4.78), respiratory disease

156 causes (diseases and medical conditions) or unnatural causes (suicides, accidents, and homicides).

157 Similar patterns were found for natural and unnatural causes of death.

158 pool mortality ratios for all, natural, and unnatural causes of death.

159 The risk of death by natural or unnatural causes was significantly higher among persons

160 al causes; MRR, 2.61 [95% CI, 1.91-3.47] for unnatural causes) than among the general population.

161 sorders were due to natural causes, 17.5% to unnatural causes, and the remainder to other or unknown

162 -risk group (5.5% compared with 2.5%) due to unnatural causes, with a nearly 8-year difference in the

163 8%) from natural causes, and 192 (1.1%) from unnatural causes.

164 e propose that the cGAS-STING pathway senses unnatural cell fusion through micronuclei formation as a

165 Unnatural chemically modified nucleotide sugars UDP-4-N3

166 3 cells, we show that a variety of different unnatural codon-anticodon pairs can efficiently mediate

167 anscribes it into mRNA and tRNA with cognate unnatural codons and anticodons, and after the tRNA is c

168 dNaM and dTPT3 into mRNAs with two different unnatural codons and tRNAs with cognate unnatural antico

169 examine the performance of a wide variety of unnatural codons, both in vitro and in the in vivo envir

170 anslation to the reduced performance of some unnatural codons.

171 bility to cross-communicate with natural and unnatural complements in both enantiomeric forms.

172 stereocenters are found in many natural and unnatural compounds.

173 sed on facial and bodily features in static, unnatural conditions.

174 g chlorine-bearing stereogenic centers with 'unnatural' configurations, with the yeast 80S ribosome,

175 , an alpha-helix, a loop) is replaced by its unnatural counterpart, with the expectation that the res

176 the synthesis of various complex natural and unnatural cyclopentanoid targets.

177 termine this key interaction, we designed an unnatural d-amino acid dipeptide that is metabolically i

178 ying a potential primary PBP responsible for unnatural D-amino acid incorporation and gaining insight

179 omprehensively establish the tolerability of unnatural D-amino acids by PBPs in both Gram-positive an

180 s that govern the metabolic incorporation of unnatural D-amino acids into bacterial peptidoglycan.

181 Incorporation of the unnatural d-proline ((D)P) stereoisomer into a polypepti

182 this study, we aimed to examine the risk of unnatural death (ie, death from external causes such as

183 The relative risk for unnatural death (IRR, 25.0; 95% CI, 22.0-28.4) was much

184 ed to account for some of the excess risk of unnatural death among people with dual-harm histories, b

185 selected cases of natural and non-suspicious unnatural death referred to Her Majesty's (HM) Coroners.

186 The risk of unnatural death was elevated for individuals with a hist

187 X-ray diffraction structure of one of these unnatural derivatives complexed to an anti-MUC1 monoclon

188 his synthetic approach also allows access to unnatural derivatives of the natural product, which woul

189 potentially other schizozygine alkaloids and unnatural derivatives.

190 he stereochemistry of the title compound, an unnatural diastereomer, and of a decalin building block

191 ay crystal structure analysis of natural and unnatural diastereomers of polyhalogenated stereohexads.

192 we report the syntheses of both natural and unnatural dibenzylbutane lignans from a common intermedi

193 s, or other evolutionarily novel features of unnatural DNA.

194 dly and accurately determine the sequence of unnatural DNA.

195 We find that the unnatural enantiomer (D residues) displays cytotoxicity

196 controlled de novo synthesis of l-NBDNJ (the unnatural enantiomer of the iminosugar drug Miglustat) a

197 al synthesis of both (-)-mitragynine and its unnatural enantiomer, (+)-mitragynine, employing a proli

198 cise asymmetric route to forging natural and unnatural (enantiomeric) C19 and C20 tetracyclic terpeno

199 A range of unnatural enantiopure fluorinated alpha-amino acids were

200 y and straightforward chemical synthesis of (unnatural) ent-(+)-verticilide provides a compelling arg

201 probe brain function are also limited by the unnatural environment typical brain imaging systems impo

202 netics and gain-of-function processing of an unnatural, epimerized hexaketide.

203 stigations and methods, many of which create unnatural experimental conditions.

204 roism spectra which are mirror imaged if the unnatural FDFD-analogue is used.

205 , in part for their ability to interact with unnatural forms of DNA created by synthetic biologists.

206 chemical properties of glycans or introduce unnatural functional groups through metabolic labeling a

207 e would enable the selective introduction of unnatural functionality.

208 (GlcNAc), N-acetyllactosamine (LacNAc), and unnatural Galalpha(1,4)-GlcNAc and Manbeta(1,4)-GlcNAc a

209 tron-deficient olefins for the generation of unnatural gamma-quaternary amino acids and other valuabl

210 ith both, the natural (Gb3-R) as well as the unnatural (Gb3-S) configuration of the 2OH group.

211 Threose nucleic acid (TNA) is an unnatural genetic polymer capable of undergoing Darwinia

212 engineering natural polymerases to replicate unnatural genetic polymers is a challenging problem.

213 Moreover, unnatural glycans on the tumor cell surface were conjuga

214 cific metabolic precursors that can generate unnatural glycans on the tumor-cell surface.

215 developed to enable tumor cells to generate unnatural glycans that contain azide groups.

216 ial lack of immune suppression, render these unnatural glycopeptides promising candidates for designi

217 hermophilus alpha-glycosidase can react with unnatural glycosides such as 6-azido-6-deoxy-d-glucose/g

218 mma-AApeptides represent a new generation of unnatural helical peptidomimetics, which have similar fo

219 ogical evaluation confirmed that natural and unnatural hinduchelins are weak iron chelators (sideroph

220 oach might lead to artificial results due to unnatural hydrophobic interactions.

221 st researchers have relied on manipulated or unnatural information as perceptual input, resulting in

222 that such SSOs might be able to retain more unnatural information than their bacterial counterparts.

223 alian cells with exogenous lipids, including unnatural lipids.

224 ted as a promising architecture with induced unnatural magnetism, especially at visible frequencies.

225 ediates, and their prevalence in natural and unnatural materials.

226 In total, 12 unnatural meroterpenoids were accessed chemoenzymaticall

227 r type I polyketide synthases (PKSs) to make unnatural metabolites commonly results in attenuated yie

228 le combinations of PIX-protein scaffolds and unnatural metal cofactors to catalyse a wide range of ab

229 erials based on coiled-coil peptides bearing unnatural metal-chelating terpyridine moieties.

230 side chains are constructed chemically, many unnatural modifications can also be directly introduced

231 lactosamine (1,6-Pr(2)GalNAz) as an improved unnatural monosaccharide for MGL.

232 priate point in the enzymatic synthesis, the unnatural monosaccharides can be converted into their na

233 Per-O-acetylated unnatural monosaccharides containing a bioorthogonal gro

234 ter during the perception of natural (versus unnatural) motion (P < 0.05).

235 ineer novel biosynthetic pathways and hence 'unnatural natural products', with potential to generate

236 Screening, using an assay employing unnatural nitrophenyl glycosides as activated donors, re

237 icient dipolarophile in THF solution to form unnatural nitroproline esters, a reaction that no enzyme

238 has become a catch-all phrase for almost any unnatural nucleic acid, raising the question: what is XN

239 ification of peptide nucleic acid (PNA) with unnatural nucleobases enables the formation of PNA-RNA t

240 he synthesis of a broad range of natural and unnatural nucleoside triphosphates (dNTPs and xNTPs) usi

241 organism (SSO) that imports the constituent unnatural nucleoside triphosphates and uses them to repl

242 Here we show that RNA containing the unnatural nucleotides is efficiently reverse transcribed

243 ns and the continuing use and development of unnatural nucleotides, experimentally characterizing all

244 l products were prepared along with numerous unnatural oligomeric congeners to provide rapid access t

245 We have prepared well-defined unnatural oligosaccharides including methylated, deoxyge

246 enantioselectivity observed with these novel unnatural organocatalysts is opposite to that obtained w

247 3 to 1.2%) of the same genotypes indicate an unnatural origin.

248 stabilization of a DNA duplex containing the unnatural P.Z base-pair when an imidazole unit is aligne

249 A short total synthesis of the novel unnatural parthenolide diastereomer (+/-)-4,5-dia-parthe

250 nting allows the construction of natural and unnatural patterns that yield important insights into hu

251 Using an unnatural, photocross-linkable amino acid, azidophenylal

252 facilitate the encoded cellular synthesis of unnatural polymers by orthogonal translation systems.

253 report a strategy for directly synthesizing unnatural polymers in cells through free radical photopo

254 redox systems can be exploited to generate "unnatural" polymers in the presence of "host" cells, thu

255 an initial step towards producing completely unnatural polypeptides in vivo.

256 rmations enable a wide diversity of natural, unnatural, posttranslationally modified (methylated, gly

257 t from other related prodigiosin natural and unnatural products and is even more intriguing in the ab

258 imicry of PTMs(3,4), as well as formation of unnatural protein variants with diverse potential functi

259 irs can efficiently mediate the synthesis of unnatural proteins in CHO cells.

260 t may have significance in context of fixing unnatural pyranoside conformation with the help of silyl

261 dent laccase-mediated system representing an unnatural radical defluorination approach is also descri

262 mance of natural protein structures with the unnatural reactivity of transition-metal catalytic cente

263 ed a dependence on the position at which the unnatural residue was incorporated.

264 These unnatural saponins have a different terminal-functionali

265 Forces of unnatural selection, such as climate change and harvest,

266 e used with terpene synthases to produce the unnatural sesquiterpenoid semiochemicals (S)-14,15-dimet

267 osaccharide engineering (MOE) strategy using unnatural sialic acids has recently enabled the visualiz

268 nally, the Imi rings have been equipped with unnatural side chains or with functionalized substituent

269 stem also allows the facile incorporation of unnatural side chains to improve activity and probe the

270 aryl amino acid tert-butyl esters possessing unnatural side chains were also accessed via glycine Sch

271 ity displayed by PBPs in tolerating entirely unnatural side chains.

272 e of externalization; when spectral cues are unnatural, sounds are perceived as closer to the listene

273 ectrical microstimulation resulted in highly unnatural spatial activation of cortex, whereas optical

274 ascade reactions resulting in the natural or unnatural steroid skeletons.

275 4000-fold increase in the specificity for an unnatural substrate.

276 (TE) domain catalytic bottleneck processing unnatural substrates in the pikromycin (Pik) system, pre

277 nctions as a gatekeeper in the processing of unnatural substrates.

278 ombinant MGAT4 and MGAT5 in combination with unnatural sugar donors.

279 Unnatural sugars can be either rationally designed to en

280 e progress to date in design and delivery of unnatural sugars for metabolic labelling of tumour cells

281 Metabolic glycoengineering with unnatural sugars provides a powerful tool to label cell

282 Here, we analyze the consequences of this unnatural template linkage on the kinetics and fidelity

283 rse thiolactomycin analogues and prepared an unnatural thiotetroamide C analogue with potentiated bio

284 synthesis of a communesin derivative with an unnatural topology.

285 This generates ssDNA molecules containing an unnatural triazole-linked DNA backbone that is sufficien

286 y, bound to an siRNA guide strand bearing an unnatural triazolyl nucleotide at position 1 (g1).

287 odactylum tricornutum, imports the requisite unnatural triphosphates from its medium and then uses th

288 e now report the synthesis and evaluation of unnatural triphosphates with their beta,gamma-bridging o

289 east in part limited by the stability of the unnatural triphosphates, which are degraded by cellular

290 nding energies of tyrosine (Tyr) and several unnatural Tyr analogs, to several orthogonal aaRSes deri

291 bserved using site specifically incorporated unnatural tyrosine analogs; however, equilibration betwe

292 The proteins with an unnatural tyrosine residue are catalytically competent.

293 urally defined catalytic center with genetic unnatural tyrosine substitution is in the radical contai

294 These unnatural UDP sugar products were then tested for incorp

295 the natural substrate, UDP-GlcNAc, over the unnatural UDP-GlcNDAz.

296 The resulting unnatural UDP-sugar donors were then tested as substrate

297 Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-

298 Homogeneous PAR oligomers and unnatural variants produced from chemical synthesis will

299 relatively greater during the perception of unnatural (versus natural) motion (P < 0.01).

300 ementary DNA from natural RNA and a range of unnatural xeno nucleic acid (XNA) template chemistries,