ライフサイエンスコーパス: unprotonated

1 gating residue, Glu(148), was protonated and unprotonated.

2 proteins would be expected to be completely unprotonated.

3 In two of these, C8 was left unprotonated.

4 y that the mouse UV chromophore is initially unprotonated.

5 analogues which were mostly diprotonated or unprotonated.

6 e that bonded to the p-nitrophenyl carbon is unprotonated.

7 pK(a) value of 7.4 for a group that must be unprotonated.

8 phenolic side chain of Tyr7 appearing to be unprotonated.

9 (2)/K(Sacc) pH-rate profiles and is required unprotonated.

10 de faster when a group with pK(a) of 6.8 was unprotonated.

11 loride, which implies that the amines remain unprotonated.

12 d an ionization (pKa = 7.6-7.8) that must be unprotonated.

13 nated to 2-3 protons and possibly when it is unprotonated.

14 and higher where the terminal amino group is unprotonated.

15 Moreover, we found that when Asp103 is unprotonated, a rigid Zn1-OH-Zn2 bridge results, while f

16 (A)(-)Q(B), one protonated (state A) and one unprotonated (alpha), and one state of the product, P(+)

17 Unprotonated amelogenins can bind protons, suggesting th

18 The results suggest that unprotonated amelogenins may regulate the pH of forming

19 hat, at least some of the time, it is in the unprotonated amine form and thus able to act as a base.

20 l evidence that it is carbamylated, since an unprotonated amine group is available to act as a Lewis

21 the amino acids, showing that the amount of unprotonated amine is the major factor determining the r

22 e and anthracene are known to be quenched by unprotonated amines by the PET mechanism.

23 The strong directing effect of the free and unprotonated amino functionality leads to high regiosele

24 ly with amino acid residues bearing thiol or unprotonated amino groups.

25 dine, leaving Nepsilon of the imidazole ring unprotonated and able to accept positive charge from the

26 is active when His-52 (pK(a) 3.8 +/- 0.1) is unprotonated and an unknown group with a pK(a) of 9.8 +/

27 is singly protonated, and the semiquinone is unprotonated and anionic.

28 l-shaped and indicate that one group must be unprotonated and another residue must be protonated for

29 e exhibiting a pK value of 6.7 which must be unprotonated and one exhibiting a pK value of 8.5 which

30 group with a pK(a) value of about 7 must be unprotonated and one with a pK(a) value of 9.5 must be p

31 ce bromide ions of CsPbBr(3) NCs through its unprotonated and protonated phosphine groups, respective

32 sorbance bands suggests that these represent unprotonated and protonated Schiff base forms of the pig

33 rate CoMFA models were built for the AAIs as unprotonated and protonated species.

34 -state NMR studies of the [2]rotaxane in its unprotonated and protonated states were carried out to l

35 nd releases metal cations, when respectively unprotonated and protonated, on effecting alternate pH c

36 s of 5.65 +/- 0.25 and 8.75 +/- 0.05 must be unprotonated and protonated, respectively.

37 residues, while leaving the N-terminal amine unprotonated and therefore reactive.

38 ee functional groups in the free enzyme, one unprotonated and two protonated.

39 itively charged at acidic and neutral pH and unprotonated and uncharged at alkaline pH.

40 thereby rendering the N(epsilon2) imidazole unprotonated and well positioned for accepting the ATP p

41 pKa = 8.3) and a second residue that must be unprotonated (apparent pKa = 7.7) for maximal catalytic

42 how the imidazole N epsilon of His-124 to be unprotonated, appropriate for general base catalysis.

43 Gas-phase conjugation to unprotonated arginine side-chains via N-hydroxysuccinimi

44 in GtCCR2 requires the Asp-96 homolog to be unprotonated, as has been proposed for the BR cytoplasmi

45 cid and the symmetric carbonyl stretch of an unprotonated aspartate, respectively, and suggest that i

46 dazolylmethylene side chains that are mostly unprotonated at neutrality because of the nearby polycat

47 vely, leaving the fluorescein moiety largely unprotonated at physiological pH and thus limiting the s

48 changes the base triple to one involving an unprotonated C41.

49 e via effects on the open probability of the unprotonated channel and the pK of one of the inhibitory

50 ening but with a lower open probability than unprotonated channels.

51 ion (VCOP(D108A)) produced a pigment with an unprotonated chromophore (lambda(max) = 360 nm) and dram

52 However, when the glutamate gate is unprotonated, Cl(-) cannot occupy this site nor, consequ

53 HS)+ protonated species but are higher-order unprotonated clusters (M3S3, M4S6, M2S4), similar to tho

54 mulations of the system having protonated or unprotonated cytosines, mimicking the pH 5.0 and 8.0 con

55 en bonding among the radical, protonated and unprotonated DMF molecules, and water.

56 ded by transient protonation of an initially unprotonated donor, which is probably the epsilon-amino

57 facial sites between DLPC and protonated and unprotonated dye I.

58 uct liking relative to earlier devices using unprotonated e-liquid.

59 ilitated for states with protonated K362 and unprotonated E286, which would in principle allow proton

60 ilitated for states with protonated K362 and unprotonated E286.

61 mechanism, with fumarate binding to the free unprotonated enzyme and a proton addition prior to malat

62 ll inhibitors bind faster and tighter to the unprotonated enzyme-NAD+ complex, which has a pK of abou

63 hich must be protonated to react with Tyr265-unprotonated enzyme.

64 order, followed by the direct attack of the unprotonated epsilon-amino group on AcCoA, transferring

65 pound I indicates that the ferryl heme is an unprotonated Fe(IV) =O species.

66 quadrupole splittings for the protonated and unprotonated ferryl forms of P450(BM3) are DeltaE(Q) = 2

67 of 5.3 for an enzymatic group required to be unprotonated for activity and a second pK of 6.3 that le

68 K199R, with a requirement for a group to be unprotonated for activity with a pK of 5.6 and a partial

69 s (pK(a) values of 6.9 and 7.5) that must be unprotonated for activity.

70 of 7.0 and 6.1, respectively, which must be unprotonated for activity.

71 residue with this pK(a) (betaLys-87) must be unprotonated for binding glycine or oxindolyl-L-alanine,

72 e exhibits the requirement for a group to be unprotonated for catalysis with a pK of 5.6 and also sho

73 yme ionization with a pKa value of 7 must be unprotonated for catalysis, and an enzyme ionization wit

74 group on the enzyme with a pK of 6.4 must be unprotonated for catalysis, and it is presumed that the

75 tin profile and 7.5 in the V profile must be unprotonated for catalysis.

76 ionization with a pK(a) of 8.5 that must be unprotonated for catalysis.

77 pK(a) value of 9.1 for a group that must be unprotonated for catalysis.

78 The pK(a) of the group that must be unprotonated for catalytic activity varied according to

79 The pKa of the group that must be unprotonated for catalytic activity was consistent with

80 The identity of the group that must be unprotonated for catalytic activity was consistent with

81 ox).L-proline complex (pK(a) = 8.02) must be unprotonated for conversion to E(red).P.

82 that a single group from the enzyme must be unprotonated for maximal catalytic activity.

83 oup with a p K a of 8.1 +/- 0.1 that must be unprotonated for nitronate formation.

84 rotonated and two functional groups that are unprotonated for optimal substrate inhibition to occur.

85 y 7 for a single enzyme residue that must be unprotonated for optimum activity.

86 t a pKa of 7.0-7.5 (for a group that must be unprotonated for optimum binding) with values, above pH

87 te having a pKa of approximately 6.6 must be unprotonated for reaction to take place.

88 e phenolic hydroxyl of Tyr265, which must be unprotonated for reaction with either isomer of alanine.

89 up with a pK(a) value of ~7.5, which must be unprotonated for the catalytic phosphorylation of ACL to

90 ith a pK of approximately 6.2, which must be unprotonated for the catalytic reaction to occur.

91 ffects also indicate that sites that must be unprotonated for transport (apparent pK(a) approximately

92 icate that CH3-H4folate binds to MeTr in the unprotonated form and then undergoes rapid protonation.

93 ge interactions, whereas the T1 state of the unprotonated form does not experience any analogous stab

94 in determining the conformation of PrP; the unprotonated form favors native PrP(C), while the proton

95 The unprotonated form of 5-HT shows the opposite orientation

96 These results implicate the neutral unprotonated form of A38 in a transition state that invo

97 y protonated forms of the inhibitors and the unprotonated form of an amino acid residue with a pK(a)

98 he enhancement factors (in log scale) of the unprotonated form of the imidazole compounds (B) and the

99 of log V vs pH indicated that at high pH an unprotonated form of the ternary enzyme complex was able

100 sts that the inhibitor binds as the neutral, unprotonated form that is subsequently protonated to gen

101 dicate that CH(3)-H(4)folate is bound in the unprotonated form throughout this pH range and that prot

102 In its unprotonated form, Lys-52 acts as a base catalyst facili

103 yl radicals have only been observed in their unprotonated form.

104 ar substrate entering the active site in its unprotonated form.

105 he other amines remain in their noncompeting unprotonated form.

106 oup that facilitates flavin reduction in the unprotonated form.

107 se enzymes are expected to use PLP in the N1-unprotonated form.

108 the order Tg > Cg > Ts > Cs for the neutral (unprotonated) form of 1 and Ts > Tg > Cs > Cg for its pi

109 hydrylase are expected to maintain N1 in the unprotonated, formally neutral state for catalysis of ra

110 nger lifetime components originated from the unprotonated forms and the shorter components from the p

111 tion exchange behavior of the protonated and unprotonated forms as well as determination of the solid

112 esonance (EPR) frequencies of protonated and unprotonated forms of a pH-sensitive probe.

113 The properties of the protonated and unprotonated forms of dIII are consistent with those exp

114 c parameters for both the protonated and the unprotonated forms of each of these two entities as well

115 Raman bands belonging to the protonated and unprotonated forms of the isoquinoline ring of papaverin

116 ectra is the presence of both protonated and unprotonated forms of these compounds.

117 he doubly protonated, singly protonated, and unprotonated forms.

118 tion results in reaction of the C-2 with the unprotonated fraction of the pyridine ring to form the r

119 ulations were done for both a protonated and unprotonated Glu and led to a proposed mechanism of prot

120 only at the 181-residue site-protonated and unprotonated Glu181-and calculate several experimentally

121 ates, which are predicted for the WT and the unprotonated glutamate variant.

122 t lower pH, suggesting the involvement of an unprotonated group acting as a base in the chemical step

123 This unprotonated group has a small DeltaH of ionization (-0.

124 or wild-type and H187Q UDG indicates that an unprotonated group in the enzyme-substrate complex (pK(a

125 h pH consistent with the participation of an unprotonated group in the reductive half-reaction and th

126 The unprotonated guanidino group of arginine can serve as a

127 ting for catalysis and with a model in which unprotonated imidazole accelerates the rate of isomeriza

128 d histidine show that His211 is neutral; the unprotonated imidazole nitrogen is not coordinated to zi

129 Addition of unprotonated imidazole results in a 5-fold increase in t

130 exen-1-one are consistent with His-186 being unprotonated in oxidized, reduced, and ligand-bound MR,

131 lu(232) in wild-type enzyme is protonated or unprotonated in the course of catalysis at neutral pH.

132 UV-sensitive cone pigments have this moiety unprotonated in the dark.

133 hat the nonbridge phosphate oxygen atoms are unprotonated in the transition state.

134 tional group binds to Na+, K+, Ca2+, and the unprotonated ionophore with binding constants of 10(3.5)

135 te of reorientation of the free carrier when unprotonated is predicted to be responsible for the coup

136 resulting intermediate, the dissociated but unprotonated leaving group forms an alkoxide coordinated

137 As such, unprotonated Lys-73 could promote serine for acylation,

138 ld reconfigure to the protonated Glu-166 and unprotonated Lys-73.

139 This gives unprotonated Lys73 and protonated Glu166.

140 alculations on models for the protonated and unprotonated (m)(X)Y...N103...H104 system compared to th

141 d that the underlying mechanism involves the unprotonated N atom acting as a H-bonding acceptor to fa

142 ound such that Asn-221 hydrogen bonds to the unprotonated N1 instead of the protonated N3 of the cofa

143 in their protonated cation form and in their unprotonated neutral form, but to date, tyrosyl radicals

144 te cavity, (3) the side chain of His64 being unprotonated (neutral) and predominantly in an inward co

145 yielded higher nicotine bioavailability than unprotonated nicotine (18 mg/mL) e-liquid (C(max), p = 0

146 of 14 kcal/mol for the formation of .NO from unprotonated nitrite substrate.

147 or the binding of two gold(I) centers to the unprotonated nitrogen atoms, despite greater orbital den

148 ring can be either protonated (pAPIRH(+)) or unprotonated (pAPIR).

149 The unprotonated peroxohemiacetal provides a branch point fo

150 roup as the 2-hydroxyl of ribose attacks the unprotonated phosphate.

151 ue in the peptide binding cleft that must be unprotonated (pK(a) = 5.8) for peptide binding and likel

152 tely 1 s time scale, which suggests that the unprotonated predecessor of Meta II in the native membra

153 s consistent with a covalent modification of unprotonated primary amines (i.e., N-terminus and epsilo

154 eactivity is analogous to that observed with unprotonated primary amines such as the N-terminus or ep

155 ves, an amide bond is formed between a free, unprotonated, primary amine group of a lysine side chain

156 yridoxal 5'-phosphate (PLP) with an unusual, unprotonated pyridine is mainly due to solvation effects

157 approximately equimolar amounts of an Ndelta-unprotonated (pyridine-like) form and an Ndelta-protonat

158 s rationalized by a greater abundance of the unprotonated radicals that preferentially abstract hydro

159 l-trans-retinal Schiff base is protonated or unprotonated, respectively.

160 We detected two ground-state unprotonated retinal photoproducts, 13-trans/15-anti (al

161 ->BR, where M(1), M(2), and M'(2) contain an unprotonated retinal Schiff base before and after a reor

162 ater 402 moves also, nearly 1A away from the unprotonated retinal Schiff base nitrogen.

163 absorption, UV-absorbing rhodopsins bind an unprotonated retinal Schiff base.

164 ude that the MUV-visual pigment possesses an unprotonated retinylidene Schiff base in the dark state,

165 Conversely, unprotonated Sap C (initially dissolved in a neutral buf

166 In the dark state, VCOP-D108A has an unprotonated Schiff base (SB) chromophore (lambdamax = 3

167 al and electrostatic effects surrounding the unprotonated Schiff base (USB) retinyl chromophore in th

168 the wild-type protein, no intermediate with unprotonated Schiff base accumulated.

169 e SWS1 pigments result from a protonated and unprotonated Schiff base chromophore, respectively.

170 These results are consistent with an unprotonated Schiff base chromophore.

171 The unprotonated Schiff base contribution (approximately 16

172 form (pH 5.5, lambda(max) = 496 nm) and the unprotonated Schiff base form (pH 8.2, lambda(max) = 384

173 ment with opsin, through both protonated and unprotonated Schiff base linkages and likely within the

174 nist is rapidly converted to an agonist, the unprotonated Schiff base of all-trans retinal, upon ligh

175 C15=NZ-CE plane breaks the connection of the unprotonated Schiff base to the extracellular side and e

176 ut illumination and in the photocycle of the unprotonated Schiff base were measured in the visible an

177 by the deletion of Phe-86 that converted the unprotonated Schiff base-linked 11-cis-retinal to a prot

178 chemical calculations strongly suggest that unprotonated Schiff base-linked chromophore is responsib

179 port the hypothesis that UV pigments have an unprotonated Schiff base-linked chromophore.

180 ase (PSB11), UV pigments uniquely contain an unprotonated Schiff-base (USB11).

181 ms shows that the photoproduct aniline, left unprotonated, serves as a poison for the QD catalyst by

182 guanidinium group, -NH-C(NH2)2+ and that the unprotonated side chain of these amino acids is responsi

183 (1) The ascorbate monoanion binds to an unprotonated site (histidine) on cytochrome b(561).

184 ationship (QSAR) models for this data set as unprotonated species assuming the Tg, Cg, and Ts conform

185 ypsin in protonated state and to thrombin in unprotonated state at P1 along with differences in the r

186 side and having that nitrogen largely in the unprotonated state facilitates its formation.

187 Only the unprotonated state of Myosin A-H810 is compatible with t

188 The catalytic lysine may be returned to its unprotonated state using a rectifying proton tunnel driv

189 d reaction of thiols with H2O2 when in their unprotonated state would provide a potential mechanism f

190 f the imidazole (15)N between protonated and unprotonated states.

191 e increasing concentration of the inhibitory unprotonated substrate.

192 g of serine is accompanied by a shift to the unprotonated tautomer of the external aldimine as well a

193 nd exists as a mixture of the protonated and unprotonated tautomers.

194 80 and 100 K, where the Schiff base remained unprotonated, the Wat85 pair stayed in similar states to

195 Schiff base counterion Asp-75, which remains unprotonated throughout the photocycle.

196 ithin the surfactant monolayer itself, while unprotonated TMA evaporates from the top 40 angstrom.

197 This suggests that the active site must be unprotonated to react with ascorbate and protonated to r

198 ur in molecules whose Schiff base linkage is unprotonated, we changed the pH of the solution bathing