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1 ancreatic cancer, but the overall benefit is unproven.
2 nd triggering insulin secretion thus remains unproven.
3 tinely because its therapeutic value remains unproven.
4 with stage II disease by chemotherapy is yet unproven.
5 ology of hypertrophic cardiomyopathy remains unproven.
6 t-important outcomes (eg, mortality) remains unproven.
7 he short term, but its long-term efficacy is unproven.
8 ), yet a direct role of CystC in AAA remains unproven.
9  CDAD, the role of preventive antibiotics is unproven.
10 disordered sleep, these relationships remain unproven.
11 ays in clinical recovery of function remains unproven.
12 -nucleotide polymorphisms, or both is as yet unproven.
13 ned popularity but its effectiveness remains unproven.
14 ese maladaptive effects, this supposition is unproven.
15 ues were important to catalysis, it remained unproven.
16 ne mediated, an autoimmune mechanism remains unproven.
17 ntegrity and clinical utility remain largely unproven.
18 iopancreatography acute pancreatitis remains unproven.
19 all-molecule discovery, but the idea remains unproven.
20 ion, their existence and mechanisms remained unproven.
21 er it is truly a more lifesaving waveform is unproven.
22 pt, although its clinical importance remains unproven.
23 function of Myc induction in this setting is unproven.
24 tinct behaviors, yet its causal role remains unproven.
25  treatment of atypical bacteria LRIs remains unproven.
26 ed with AMD3100 alone, however, has remained unproven.
27 on have employed splenectomy, its utility is unproven.
28 al autoimmune cause has been proposed but is unproven.
29  action at the time of the rise in Zn(2+) is unproven.
30 fect on insulin resistance in humans remains unproven.
31 le; however, this hypothesis remains largely unproven.
32 y or cancer related to AHR activation remain unproven.
33  has been proposed, but its efficacy remains unproven.
34 nce of apoptosis in LPS-induced ARF remained unproven.
35 their existence in intact myocardium remains unproven.
36 mortality rate in human septic shock remains unproven.
37 ermining the most suitable treatment remains unproven.
38 us because the subset selection criteria are unproven.
39 let alone ultrasound screening programmes is unproven.
40 s other putative resistance mutations remain unproven.
41 otential to treat or prevent disease remains unproven.
42 er chronic cardiac muscle diseases is so far unproven.
43                                 Causality is unproven.
44 oral immunity contributes to host defence is unproven.
45 mall units, although this suggestion remains unproven.
46 the efficacy of such devices for this use is unproven.
47 r and recognition of homology occurs remains unproven.
48 sks, a major role in memory consolidation is unproven.
49 gainst brain antigens, although this remains unproven.
50 ry, but the benefit of this strategy remains unproven.
51 oplasmic antibodies (ANCA), however, remains unproven.
52 urons, but the mechanism of toxicity remains unproven.
53 pproach at a regional or state level remains unproven.
54 ion (LTD)-like mechanisms is widely held but unproven.
55 tay of treatment because adjuvant therapy is unproven.
56             However, this hypothesis remains unproven.
57 e glucose metabolism post transplantation is unproven.
58 heir existence, which, however, has remained unproven.
59 ough the benefit to overall survival remains unproven.
60  are suspected to occur in humans but remain unproven.
61 keeping achieves these goals remains largely unproven.
62 function in sexually transmitted diseases is unproven.
63 the use of preradiation chemotherapy remains unproven.
64 hemical significance of most factors remains unproven.
65 stic utility outside the research setting is unproven.
66 lites to aid in diagnosis and triage remains unproven.
67 of the GRS in improving care and outcomes is unproven.
68 ange of clinical summarization tasks remains unproven.
69  effectiveness in clinical diagnosis remains unproven.
70 ority compared with clinical gestalt remains unproven.
71 can during the vaccine priming phase remains unproven.
72 eplacement (TAVR), but their benefit remains unproven.
73  its influence on their metabolic actions is unproven.
74 d interventions, their long-term effects are unproven.
75 nical utility in real-world settings remains unproven.
76 est its safety, but clinical benefits remain unproven.
77 nely used in many countries, but efficacy is unproven.
78 red as a treatment, but the efficacy remains unproven.
79 ated fungi, although their link here remains unproven.
80       However, a causal relationship remains unproven.
81 ignificant marginal survival benefit-remains unproven.
82 vacuoles in reducing root metabolic cost was unproven.
83 ese mice, yet, a causal relationship remains unproven.
84  of this pain have been suggested but remain unproven.
85 variable and long-term durability is largely unproven.
86 psychotic/bipolar/common mental disorders is unproven.
87 early detection, but the survival benefit is unproven.
88 ly available for testing remains unclear and unproven.
89 diet on age-related brain atrophy is largely unproven.
90 noscale mechanism through which they flex is unproven.
91 The role of anti-inflammatory agents remains unproven.
92 fection, but protection in male mice remains unproven.
93 ith or without beta-lactamase inhibitors, is unproven.
94 sed, although this remains controversial and unproven.
95 address these challenges, they have remained unproven.
96 ver, its role as a driver of relapse remains unproven.
97 er core has been suggested, but has remained unproven.
98 care metrics without such monitoring remains unproven.
99 pe in patients with renal failure is largely unproven.
100 interprofessional ICU rounds is assumed, yet unproven.
101 associated with seropositivity, causality is unproven.
102 atile reproductive hormone secretion remains unproven.
103 ty for routine disease diagnosis is, as yet, unproven.
104 oposed to have other functions, which remain unproven.
105 he existence of a specific mechanism remains unproven.
106 dvantage in minimally dehydrated children is unproven.
107 atients is of interest, but the benefits are unproven.
108 ve glucose metabolism posttransplantation is unproven.
109 s with established Chagas' cardiomyopathy is unproven.
110                     This possibility remains unproven.
111 ow anterior resection (RLAR) remains largely unproven.
112 s and modes of ligands at the surface remain unproven.
113 of GATA4 in the developing human pancreas is unproven.
114 iglyceride storage in adipose tissue remains unproven.
115 although their clinical significance remains unproven.
116 tandard of care without such testing remains unproven.
117 general anesthesia is implicated but remains unproven.
118 earance of some species remains possible but unproven.
119 surface environments where they form remains unproven.
120 oesophageal reflux, but its effectiveness is unproven.
121 ts, and synthetic conduits are promising but unproven.
122 cedures remain experimental and any benefits unproven.
123 any potential benefit from this procedure is unproven.
124 nabolism in patients with advanced cancer is unproven.
125 ent at least, the present hypothesis remains unproven.
126 mum acceptable center volume or threshold is unproven.
127 t on patient outcomes in routine practice is unproven.
128 these factors in endothelial biology remains unproven.
129 for KC chemoprevention, although this use is unproven.
130                                     Although unproven, a potential for central pontine myelinolysis a
131 n reduce the incentive to enrol in trials of unproven agents, for which safety is not assured.
132 , hyaluronic acid (HA) and a small number of unproven alternative therapies.
133 les of MAIT cells in human infections remain unproven and clinical conditions associated with selecti
134 d trigger for T1D, but a causal role remains unproven and controversial.
135 ty in adult women, but this approach remains unproven and experimental in children and adolescents.
136 stiocytic neoplasms, this remains clinically unproven and many of the kinase mutations that are found
137 ncept suggested by murmur variation, remains unproven and of unclear mechanisms.
138 hyperkalemia before turning to these largely unproven and potentially harmful therapies.
139      Their global biological significance is unproven and remains controversial.
140 ese conditions, while outlining what remains unproven and requires further testing to move the field
141 es are completed, precision oncology remains unproven, and as such, a hypothesis in need of rigorous
142 ombotic processes in these disorders remains unproven, and the issue of antithrombotic prophylaxis is
143                 However, this action remains unproven, and the role of endogenous pancreatic trypsin
144 tances beyond lowering blood pressure remain unproven, and there is uncertainty about the greater ren
145 f diseases; however, this hypothesis remains unproven, and, indeed, a specific role for T cells in th
146 mental agents with substantial toxicities or unproven antitumor activity.
147                             An important but unproven approach is to have hospitals in a region coord
148  The testing and implementation of novel yet unproven approaches to HIV eradication that could compro
149 ic therapies to include those that, although unproven, are plausibly effective and prudent to use.
150 otentially serious complications and remains unproven as a treatment modality.
151 s limitations, and their generalizability is unproven as there is an absence of baseline results amon
152                                           An unproven assumption is that homologous genes have a comm
153                                           An unproven assumption of this model, which is essential to
154        These results confirm a long-held but unproven assumption that lysosomes are the final destina
155 irions also support a generally accepted but unproven assumption that most particles contain 1 dimer.
156               However, they are based on the unproven assumption that no two fingerprints, even from
157                       Even when based on the unproven assumption that protons will permit a 10-Gy esc
158 inding, supporting the common yet previously unproven assumption that receptor binding does not produ
159  of the kinetic radical chain: the tacit but unproven assumption that the speed of reaction is determ
160 ontributed to confusion in the field, is the unproven assumption that the TVCV and TMV life cycles ar
161 ol to atherogenesis and make unwarranted and unproven assumptions about physician behavior.
162 consistent with what is known, but make some unproven assumptions.
163 nonsteroidal anti-inflammatory drugs remains unproven because long-term visual outcomes and comparati
164                      This hypothesis remains unproven because SPT has been refractory to purification
165 oring relate to setting high expectations of unproven benefit and not utilizing the technology to gai
166 lpha activity have been disappointing, or of unproven benefit at best.
167 aim at reduction of sun exposure, but are of unproven benefit, especially for basal-cell carcinoma.
168 moking), risk factor reduction strategies of unproven benefit, medical therapy to prevent myocardial
169        In addition to being expensive and of unproven benefit, the current policy of routine exercise
170                 Nonspecific therapies are of unproven benefit.
171 3 were categorized as being of promising but unproven benefit.
172 ied to treatments with high or promising but unproven benefit.
173 fit and 33% (88/267) indicated promising but unproven benefit.
174 ytic agents has shown promise but remains of unproven benefit.
175 stem cell treatment should be aware of their unproven benefits and potential risks, including serious
176 ous immunoglobulins and plasma exchange have unproven benefits, but may provide short-term effects.
177                  However, this model remains unproven biochemically and the biologically active form(
178 onal goals in behavior, as it is based on an unproven biological paradigm (Dawkins's selfish gene the
179                                  However, an unproven but long-held conjecture holds that spatial lea
180 s precede the cartilage degeneration remains unproven but may best be considered necessary for progre
181 the Surviving Sepsis Campaign guidelines are unproven but seem reasonable and practical.
182 detect seizures and postictal stimulation is unproven but warrants further study.
183        The cause of the warm temperatures is unproven but widely attributed to high levels of atmosph
184                                 These remain unproven, but are of continuing interest.
185  asymptomatic primary hyperparathyroidism is unproven, but data suggest that surgery decreases fractu
186 omy in the management of the disease remains unproven, but there is widespread acceptance of the noti
187                         Treatment of NASH is unproven, but weight reduction is recommended in obese p
188 ressure on supply side changes combined with unproven carbon removal technologies.
189 Stem cell tourism," the practice of offering unproven cellular preparations to patients as approved t
190 , the proportion of physicians endorsing the unproven claim that the drug reduced cardiovascular risk
191  has been criticized for its emphasis on the unproven clinical relevance of immunophenotype.
192 ese tests are performed, MEOR will remain an unproven concept rather than a highly desirable reality.
193 d in the 1990s, but was withdrawn because of unproven concerns about safety, which led to insufficien
194 y used one-way functions are either based on unproven conjectures or have known vulnerabilities.
195 rix metalloproteinases (TIMPs), has remained unproven despite frequent coregulation of MMPs and TIMPs
196 f a change to opting-out legislation remains unproven, despite the apparent association between optin
197 rapeutic strategy, but its potential remains unproven due to a lack of drugs capable of efficiently r
198 he presumed benefits of valve surgery remain unproven due to lack of randomized controlled trials.
199  toxicity of immunosuppression, expense, and unproven effects on the secondary complications of diabe
200 9) are imperfect, possessing only partial or unproven efficacies and other limitations that constrain
201 eatments for PPI-refractory heartburn are of unproven efficacy and focus on controlling gastroesophag
202  received prophylactic antibiotic therapy of unproven efficacy and underwent unnecessary, costly sero
203 acute myocardial infarction (AMI) but are of unproven efficacy in AMI with left ventricular (LV) dysf
204 caution against prolonged use based on their unproven efficacy in humans, including possible detrimen
205 re supported by clinical trials, many are of unproven efficacy.
206 , RJ Reynolds attributed these results to an unproven epinephrine-related stress response from odor o
207 lacement therapy (NRT) treat smoking but are unproven for alcohol, and clinical trials rarely include
208 in's proclivity towards condensation remains unproven for valorizing both lignin and carbohydrates to
209  two genes (dpsC, dpsD) encoding proteins of unproven function, both absent from other type II PKS ge
210 erimental evidence for the long-standing and unproven fundamental idea that high thresholds for plast
211 he sole mediator of KM822 actions in vivo is unproven given the large number of potential off-target
212                            A reasonable, but unproven, goal for treatment is a plasma total homocyste
213  in each two-domain subunit suggests a still unproven hydrolytic function of the protein.
214 iously inaccessible experiments to test many unproven hypotheses surrounding the ever-enigmatic DOM.
215                         A long-standing, but unproven hypothesis is that menopause symptoms cause cog
216 attributed to specific loci, this remains an unproven hypothesis.
217                    However, it still remains unproven if anticoagulation reduces cognitive decline an
218 g lung cancer screening with a promising but unproven imaging procedure, helical computed tomography
219  assess mitochondrial pyruvate metabolism is unproven in cancer.
220 oing cardiac surgery, but these benefits are unproven in critically ill children at risk for hyperins
221 hough the role of varicella vaccine remained unproven in most serious adverse event reports, there we
222 rategies that have more support but that are unproven in practice and may be more expensive.
223 tion (DMR), but its link to outcomes remains unproven in routine clinical practice.
224  to FDT perimetry, but the techniques remain unproven in screening settings.
225 rength of the available data into proven and unproven indications for stent use.
226  comply with resource intensive and arguably unproven initiatives to monitor and improve patient safe
227 g apoptosis in these in vivo settings remain unproven, insights into the molecular circuitry controll
228         Exercise training is a promising but unproven intervention for improving the cardiovascular o
229 uraged a reflexive reliance on expensive and unproven interventions such as dietary supplements and m
230                                     Although unproven, it is generally accepted that trypanosomes rea
231 upport devices remain an exciting but as yet unproven means of supporting acute liver failure patient
232                            The proposed, yet unproven, mechanism underlying digoxin's positive inotro
233 ns that the casting of a wide net with still-unproven metrology methods may stifle the development an
234 cremental risk from participation (63%), the unproven nature of the treatment (70%), the uncertainty
235 ough the clinical importance of CSCs remains unproven, new evidence suggests that the limited durabil
236 rs' knowledge and reduced enthusiasm for the unproven, off-label indication of reducing cardiovascula
237                  Three genes with previously unproven phenotypes in gastrointestinal infection were t
238                  Although the mechanisms are unproven, poloxamer 188 treatment may accelerate thrombo
239 crobial population size, without invoking an unproven pool that is intrinsically stable for centuries
240 ted by structural considerations, remains an unproven possibility.
241  viewpoint, but its feasibility is currently unproven, potentially owing to a lack of compatible dono
242                  Promising but still largely unproven preventive respiratory treatments include: high
243 g Internet-based industry that aims to offer unproven procedures to patients with incurable diseases.
244 so preventing harm from inappropriate use of unproven procedures.
245 eterioration in Leydig cell function remains unproven, recent data suggest an adverse effect of varic
246 nts has become essential as improvised often unproven regimens are implemented.
247 t and low availability of the catalysts, and unproven scalability.
248 they are nevertheless heuristic methods with unproven scaling.
249       Testicular self-examination remains an unproven screening modality that is suboptimally perform
250                      Although histologically unproven, severe acute respiratory syndrome coronavirus
251 Although many of these new modalities remain unproven, some show much promise for decreasing the morb
252 engaged in direct-to-consumer advertising of unproven stem cell interventions has raised troubling qu
253 net-based industry where in patients receive unproven stem cell interventions.
254 titioners working for US companies marketing unproven stem cell procedures.
255  were identified as offering a promising but unproven substantial benefit.
256 ecause the value of adjuvant therapy remains unproven, surgery is the mainstay of therapy for these t
257                       Interim PET remains an unproven test for routine clinical practice.
258                                   It is also unproven that challenging work in a demanding environmen
259                                        It is unproven that happiness is a direct cause of good health
260 ings are not inconsistent with the hope, yet unproven, that persons might reduce their risk of dement
261                It is widely accepted, though unproven, that phosphatidylinositol transfer between mem
262      This is based on the assumption, as yet unproven, that these interventions will prevent or decre
263                     It is possible, although unproven, that they also mediate binding of chromatin to
264                 Although this speculation is unproven, the observation that there are separate popula
265 escribe turbulence, their regularity remains unproven; the implicit assumption being that the self-st
266 s to free the nosology from the influence of unproven theories, and the philosophy was driven largely
267                       We tested the popular, unproven theory that tinnitus is caused by resetting of
268  been proposed to promote inflammation-a yet unproven theory.
269  has led patients and their families to seek unproven therapeutic approaches.
270                             In recent years, unproven therapies have been widely practiced outside th
271                                        Using unproven therapies outside of a randomized trial slows r
272 ution about unscrupulous 'clinics' marketing unproven therapies to patients.
273 eatment, discussing Internet information and unproven therapies, phase I trial enrollment, and workin
274 of DUOX1 in mammalian organisms has remained unproven to date.
275  results provide support for the common (yet unproven to our knowledge) notion that arm muscles do no
276             Caveolae provide a possible, yet unproven, transcellular pathway to overcome such barrier
277 s nerve stimulation remains a promising, yet unproven treatment in HFrEF.
278 ugary foods and beverages is a plausible but unproven treatment.
279  lives by refusing vaccinations or demanding unproven treatments.
280            Viruses are suspected but usually unproven triggering factors in autoimmunity.
281                              In our society, unproven, unorthodox, or unnoticed researchers may not r
282 pplied to agriculture and food production is unproven, unsafe, untested, unregulated and unwanted.
283 targeting inflammation improves outcomes was unproven until the recent results of CANTOS (Canakinumab
284 for this therapy, it should be considered of unproven value and, therefore, experimental.
285 stroesophageal reflux disease symptoms is of unproven value, and recommending bodies are divided as t
286                      Medical treatment is of unproven value, even beta-blockers and angiotensin-recep
287 cer risk reduction and are of promising (but unproven) value.
288  behind organic productivity cycling are yet unproven, we postulate that they may have been linked to
289                                   It remains unproven whether non-treatment of moderate or greater re
290                                  It is still unproven whether prophylactic antibiotics can reduce mor
291                                  It is still unproven whether these results apply to higher-risk subg
292                              However, it was unproven whether this change would increase the total am
293 ease at an earlier and curable stage remains unproven, with key results expected in 2015.

 
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