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1 ormation of a permissive metastatic niche is unresolved.
2 that determine such variable outcomes remain unresolved.
3 ugh the course of chronic infections remains unresolved.
4 teractions with CRISPR-based immunity remain unresolved.
5 erminal domain (NTD) within chromatin is yet unresolved.
6 ecombination or by creating new mutations is unresolved.
7  plan, but their evolutionary origin remains unresolved.
8 ever, its role in active force generation is unresolved.
9 from these cells in neuropathic pain remains unresolved.
10 ts but the extent and nature of this remains unresolved.
11 hanisms to explain these observations remain unresolved.
12 lass 2), imaging-based risk modeling remains unresolved.
13 ic and terrestrial ecosystems remain largely unresolved.
14 er, the hydrogen bonding partnership remains unresolved.
15  question of their temporal dynamics remains unresolved.
16 ing this differential disease association is unresolved.
17 at how PLK1 controls RhoA activation remains unresolved.
18 s governing activation and regulation remain unresolved.
19 iganded states, the menthol-bounded state is unresolved.
20 ands became principally manipulative remains unresolved.
21 ture, the native structure remains partially unresolved.
22  nanoscale metallic glasses, however, remain unresolved.
23  its role in gene regulation remains largely unresolved.
24 y of autism spectrum disorder (ASD) is still unresolved.
25 ccessional forests to climate change remains unresolved.
26 f 687 patients, leaving only 20 (2.9%) cases unresolved.
27 g morphine analgesic tolerance still remains unresolved.
28 ion between tumour-bearing hosts are largely unresolved.
29 uence chromatin dynamics at ZGA has remained unresolved.
30 ructural basis of these effects has remained unresolved.
31 volcanic flux and composition remain largely unresolved.
32 of Mycobacterium tuberculosis (Mtb) is still unresolved.
33 he exact nature of its contributions remains unresolved.
34 hematopoiesis, and tumor suppression remains unresolved.
35 y and functions of their gut microbiomes are unresolved.
36 d their hemispheric specialization are still unresolved.
37 escales-and whether any survive today-remain unresolved.
38 etic structures, and flowers, is empirically unresolved.
39  other beta-barrel proteins use has remained unresolved.
40 uenced by host diversity, but the causes are unresolved.
41 hanism associated with these effects remains unresolved.
42 tion of normal epithelial cells has remained unresolved.
43 x, are redundant, or have different roles is unresolved.
44 ping flight or only passive gliding is still unresolved.
45 ture; however, regional discrepancies remain unresolved.
46 PPIase) domains, the role(s) of which remain unresolved.
47 ing of the pore domain's ion channel remains unresolved.
48      The significance of one variant remains unresolved.
49 F21, and FGF1 in the mammalian brain remains unresolved.
50  yet to date a few important pathways remain unresolved.
51 define regions of cortical contractility are unresolved.
52 mitochondrial metabolism in the light remain unresolved.
53 are encoded in a single DNA sequence remains unresolved.
54 pulations appear and stably co-exist remains unresolved.
55 on to major retinal degenerative diseases is unresolved.
56 The underlying mechanisms of defoliation are unresolved.
57  mechanism of KSHV infection remains largely unresolved.
58  infection, its regulation remained thus far unresolved.
59  many questions about penis evolution remain unresolved.
60 respond to glucose in type-2 diabetes remain unresolved.
61  the advance of the replication fork remains unresolved.
62 ogical function, many basic questions remain unresolved.
63  its nuclear translocation mechanism remains unresolved.
64 istence in the deep ocean and in sediment is unresolved.
65 variants affect mammary tumorigenesis remain unresolved.
66 functions, but their molecular basis remains unresolved.
67 tivities to temperature fluctuations remains unresolved.
68 ast, but precise molecular details are still unresolved.
69 mine efficacy of remyelinating drugs remains unresolved.
70 root adaptation to Mn deficiency are largely unresolved.
71 ver, the causal relationships remain largely unresolved.
72 d for its localization and processing remain unresolved.
73 ar environment for long-range action remains unresolved.
74 act nature of their respective roles remains unresolved.
75  of the optimal state for sensory processing unresolved.
76 ease in survivors of childhood cancer remain unresolved.
77  complete picture for their behavior remains unresolved.
78 cal astringency of Plavac mali wine remained unresolved.
79 selves from the toxicity of cyanide remained unresolved.
80  and theoretical efforts, the puzzle remains unresolved.
81 ficity on neonatal tT(reg) cell selection is unresolved.
82 esearch, how plants biosynthesize SA remains unresolved.
83 to the mechanisms of conduction still remain unresolved.
84 ed state in these abundant materials remains unresolved.
85 r some currently open questions that are yet unresolved.
86 in S4 during the activation process is still unresolved.
87 sible for its formation and evolution remain unresolved.
88 is process, but underlying mechanisms remain unresolved.
89 r act indirectly through circuit elements is unresolved.
90 sticity in cold hypoxic environments remains unresolved.
91 ms contributing to lifespan variation remain unresolved.
92  its contribution to cognitive impairment is unresolved.
93  intellectual disability and epilepsy remain unresolved.
94 ular consequences of this variation remained unresolved.
95  roles of Wnt ligands in this process remain unresolved.
96 e mechanism of the Grignard reaction remains unresolved.
97 defects; thus, how Wnts regulate PCP remains unresolved.
98 ected by the onset of acoustic experience is unresolved.
99 lpha-estradiol elicits these benefits remain unresolved.
100  of twist in condensed chromatin remains yet unresolved.
101 fects behind these observed associations are unresolved.
102 he human-like pattern of pelvic list remains unresolved.
103 internal physiological states-remain largely unresolved.
104 n, but the generality of this effect remains unresolved.
105 and, to date, this critical question remains unresolved.
106 lutionary significance of Facivermis remains unresolved.
107 ensity and under reducing atmosphere remains unresolved.
108 ven the very existence of lipid rafts remain unresolved.
109 a parasite, yet its natural function remains unresolved.
110 ng the surround of the AII, however, remains unresolved.
111 osystem driver across biomes remains largely unresolved.
112 croglia recruitment to Abeta plaques remains unresolved.
113 ty in small mammals at high altitude remains unresolved.
114 misfolded proteins by mechanisms that remain unresolved.
115 d are modified by breastfeeding practices is unresolved.
116 driving climate change under warming remains unresolved.
117  circuits in network synchronization remains unresolved.
118  being impacted by threats, yet this remains unresolved across most of Earth.
119 ysics and chemistry questions that are still unresolved after many decades.
120 across many neuronal subsets remains largely unresolved, although available evidence implicates subse
121 ism required to drive the solar wind is also unresolved, although candidate mechanisms include Alfven
122 ted to a short tetracysteine sequence at the unresolved amino-terminus and cerulean, a cyan fluoresce
123  circuit(s) that generate these seizures are unresolved and are the focus of studies reported here.
124 ation and enhanced our knowledge on hitherto unresolved and contentious issues concerning the efficac
125 h an enzyme required to process a variety of unresolved and hemi-resolved branchpoints in DNA.
126 equire a nuclease that can process remaining unresolved and hemi-resolved DNA junctions and other bra
127 l origins of this anomalous subdiffusion are unresolved, and model systems capable of quantitative an
128 in regulating early cell-fate choice remains unresolved, and the coordination between different molec
129 of degradation of most host proteins remains unresolved, and the functions of many viral proteins are
130 th-linked biodegradation vs cometabolism are unresolved, and the impact of different environmental fa
131 systemic bone loss and periodontitis remains unresolved; and the trabecular bone score (TBS) is a new
132                                        These unresolved aspects of CTE underlie disparate claims abou
133                                              Unresolved aspects of this relationship include what cau
134 igh degree of complexity that typically goes unresolved at masses above ~150 kDa.
135 omaterial formulation and address a critical unresolved barrier for clinical translation of gold nano
136 ffinities of this "form-taxon" are currently unresolved, but we note that C. multiseminalis propagule
137 tions, we show that the crystallographically unresolved C2 loop plays a crucial role in the structura
138 of a systemic failed immune response against unresolved cancer.
139 atly improve diagnostic yield in genetically unresolved cases of Mendelian disease, defines strengths
140                        In 121 (17.6%) of 687 unresolved cases, ID-H/PF4-PaGIA was used as second-line
141 e breast cancer clinical setting, with major unresolved challenges residing in target selection, deve
142 is can facilitate the molecular diagnosis of unresolved clinical cases and highlights the potential v
143  fibrillation is a longstanding, common, and unresolved clinical challenge.
144 in a cohort of 122 patients with genetically unresolved clinical diagnosis of ADPKD or polycystic liv
145 pure atypical ductal hyperplasia (ADH) is an unresolved clinical issue.
146   Cancer recurrence after surgery remains an unresolved clinical problem(1-3).
147 eatment-resistant prostate cancer is a major unresolved clinical problem.
148 the DIVERSITY trial (NCT01895777) and had an unresolved clinical thrombosis risk factor requiring fur
149 arbon mixtures instead characterize them as "unresolved complex mixtures", with quantification limite
150                        However, owing to the unresolved complexity of the membrane and the structures
151  inaccessible buried features and previously unresolved conduction pathways, crucial for optimizing h
152 ongoing questions, technical challenges, and unresolved controversies relating to the mechanisms and
153                              To address this unresolved controversy, we applied recent advances in ma
154 rticle, I review several emerging themes and unresolved debates in the social-psychological study of
155 ite some characteristic challenges remaining unresolved, designed polypharmacology holds enormous pot
156            The remaining 62 (32%) cases were unresolved despite specialist pathology and methylation
157 cture of human IL-11 that reveals previously unresolved detail.
158 intrinsic lethal reactive oxygen species and unresolved DNA damage and limits extrinsic myeloid and l
159 ition, decreased rates of DNA synthesis, and unresolved DNA damage.
160 duces apoptosis of GC B cells, likely due to unresolved DNA lesions in cells attempting to undergo cl
161 lation of cytosolic DNA fragments because of unresolved DNA lesions, which in turn activated the DNA-
162 n-repair mutants, even when the abundance of unresolved DSBs is high.
163 hanisms responsible for biased signaling are unresolved due to a lack of insight into the phosphoryla
164             identify seven foundational, yet unresolved, ELSI issues posed by portable neuroimaging:
165 years ago), but their origin has remained an unresolved enigma in palaeontology since the nineteenth
166 asis is a long-standing problem that remains unresolved, especially in multicellular organisms.
167 onset epilepsy and suspected encephalitis of unresolved etiology and equivalent results in autoantibo
168 aging of the human vasculature represents an unresolved experimental challenge.
169                      Finally, we discuss two unresolved fundamental questions: (i) why does repeat be
170 as been finished end to end, and hundreds of unresolved gaps persist(1,2).
171 uencing (WES) data from 138 individuals with unresolved generalized dystonia of suspected genetic eti
172  variant in a small family with a previously unresolved genetic diagnosis.
173                 One of the most distinct but unresolved global patterns is the apparent variation in
174 ps among major lineages in the family remain unresolved, hampering comparative research.
175                            These objects are unresolved (having a size of the order of 100 astronomic
176 letion during the resolution phase exhibited unresolved hepatic inflammation, activation of the fibro
177 lly convergent approach has left the problem unresolved, heretofore.
178 flammatory (M1) response, associated with an unresolved host response in the long-term.
179 ch as Caenorhabditis elegans have left still unresolved how neural circuits integrate and respond to
180                              Yet, it remains unresolved how sorting into diverging vesicular routes i
181  via undirected random walks, but it remains unresolved how these random walks generate an efficient
182 cs of bistability, a larger question remains unresolved: how this phenomenon informs us on generic pe
183                                              Unresolved, however, is a debate about the source materi
184 of XPD, and allows the mapping of previously unresolved human disease mutations.
185                                        It is unresolved if or to what extent translational selection
186 port across the symbiosomal membrane remains unresolved in all bacteriocyte-containing insects.
187 a segment of the N-terminal globular domain, unresolved in crystallographic structures, comprises a f
188           How plant seeds originated remains unresolved, in part due to disconnects between fossil in
189 l nervous system raise questions that remain unresolved, in part due to the absence of precise pharma
190 ins and spread of treponemal diseases remain unresolved, including syphilis' potential introduction i
191                             In patients with unresolved inflammation at the final visit, mean follow-
192 recise mechanisms that define the genesis of unresolved inflammation in heart failure with preserved
193                                  Persistent, unresolved inflammation in the liver represents a key tr
194                                      Chronic unresolved inflammation is the primary determinant of ca
195 mmune cell subset has been implicated in the unresolved inflammation of PD, regardless of host metabo
196 longitudinally to comprehend the dynamics of unresolved inflammation that leads to disease developmen
197 at leads to chronic wounds or disease due to unresolved inflammation.
198 The condition is characterized by a chronic, unresolved inflammatory process thereby contributing to
199 eyond physiological control, resulting in an unresolved inflammatory response of the CNS-resident imm
200               TgDrpC, whose function remains unresolved, is unusual in that it lacks a conserved GTPa
201 major isomer-specific peak broadening due to unresolved isotopomer mixtures.
202 s alleviated by a hearing device is a major, unresolved issue for rehabilitation.
203  for their expression have long been a major unresolved issue in the field of epigenetics.
204                                           An unresolved issue is how ASMase residing within lysosomes
205                             However, a major unresolved issue is how the individual component traits
206 face contamination has long been a critical, unresolved issue, given graphene's two-dimensionality.
207 nduction into damaged sites has long been an unresolved issue.
208 ays to spatial vision is a long-standing and unresolved issue.
209 d post-procedural evaluation and management, unresolved issues and future perspectives.
210     We conclude with a discussion of several unresolved issues in the field.
211 nd mesenteric vein thrombosis, but there are unresolved issues regarding monitoring with both the ant
212 igin-free (CD-AOF) media and supplements are unresolved issues that hamper the clinical applicability
213                      Here we addressed these unresolved issues using simultaneous recordings from mul
214                                   To address unresolved issues with respect to the evolutionary relat
215  of the normalization model, there are three unresolved issues.
216 in homeostasis and cancer development remain unresolved issues.
217 g of tree physiology and scaling, indicating unresolved issues.
218 cross the inner mitochondrial membrane by an unresolved mechanism.
219 immunotherapeutic strategies, through as-yet unresolved mechanisms.
220 e (site 1) within the flexible, structurally unresolved N-terminal APN region using direct binding fl
221 a pore plug, indicating that this previously unresolved N-terminal peptide is responsible for a ball-
222  methylation analysis of peripheral blood in unresolved ND/CAs.
223 in previous "supertree" approaches, in which unresolved nodes led to branch-length artifacts.
224 rior to the surface, resolving long-standing unresolved observations of incomplete PAH decay upon pro
225 lecules, which renders tumour penetration an unresolved obstacle to an effective anticancer drug deli
226 he lack of a clear seasonal profile for this unresolved OC suggests that it may be a primary source r
227 rial ocean circulation (and small changes in unresolved ocean processes)-that is, by the patterns of
228 nd often reveals molecular features that are unresolved on lower performance instrumentation.
229                         HEDGES also converts unresolved or compound errors into substitutions, restor
230 The mechanism of tau fibrillogenesis remains unresolved, particularly early events that trigger the m
231 s and proved to be essential in the event of unresolved peaks from CPC and SFC chromatograms.
232 pletion on asteroids is a long-standing, yet unresolved phenomenon that is of fundamental importance
233 clinically relevant fluid volumes remains an unresolved problem in biomedicine and diagnosis.
234       The origin of eukaryotes represents an unresolved puzzle in evolutionary biology.
235 y species is maintained is a fundamental and unresolved question in ecology.
236 tion, measured in single cells, to answer an unresolved question in the field-whether receptor endocy
237                                      A major unresolved question in understanding visually guided loc
238                                      A major unresolved question is how bacteria living in complex co
239  of intense interest in neuroscience, but an unresolved question is how sensory information from hear
240                                           An unresolved question is how the brain allocates attention
241                                           An unresolved question is how the brain solves this binding
242                                           An unresolved question is to what extent such age-related a
243                                        A key unresolved question is understanding which physiological
244                                   A critical unresolved question is whether generation of protrusions
245                                      Another unresolved question is whether predictive processes are
246                                    The major unresolved question is why some cell lines fail to restr
247 ts provide a positive answer to the hitherto unresolved question of whether neurodegeneration (e.g.,
248 is and thereby impact neuronal loss is a key unresolved question.
249 ion of GIP to promote weight loss remains an unresolved question.
250 stem beyond Anderson localization remains an unresolved question.
251 lls inactivate Hippo signaling remains a key unresolved question.
252 ently regulate their locomotion system is an unresolved question.
253 through mitotic cell divisions remains a key unresolved question.
254 estation of such behaviors evolve remains an unresolved question.
255 t-7 (AR-V7) in prostate cancer biology is an unresolved question.
256                                              Unresolved questions about pre-implantation human develo
257                           However, there are unresolved questions about the ideal pharmacokinetic cha
258                           Our results settle unresolved questions about the lattice dynamics and ther
259                                      Several unresolved questions are discussed in the context of ast
260  we contend that issues including continuing unresolved questions around mechanism; opportunities aff
261 pair, discussing recent findings and raising unresolved questions around this intriguing immune cell.
262                     Here, we addressed these unresolved questions by investigating BBA recorded using
263                                      Crucial unresolved questions include the expression of multiple
264                                    There are unresolved questions regarding the association between p
265                                              Unresolved questions regarding the mechanism of ER-phagy
266                                          Key unresolved questions regarding the role of aspirin in pr
267                       We will also highlight unresolved questions related to B cell activation and to
268        Allergens induce type-2 immunity, but unresolved questions remain about initiation of this res
269 (E1) is known to interact with SOST, several unresolved questions remain, such as the reason why SOST
270 recent mechanistic insights and highlighting unresolved questions.
271  the molecular basis of OS structure remains unresolved, recent studies suggest that the photorecepto
272 the economic importance of B. napus, much is unresolved regarding its phylogenomic relationships, gen
273           Therefore, isomeric GPLs are often unresolved, representing a significant challenge for sho
274  Cruickshank Diffraction Precision index, or unresolved residues.
275 iciency in completing mtDNA synthesis due to unresolved RNA:DNA hybrids across mtDNA.
276                                    When left unresolved, RNA-DNA hybrids can slow replication fork pr
277 rameters is to account for both processes at unresolved scales and changing properties of evolving sy
278                 Interactions of processes at unresolved scales with those at resolved scales should b
279 of turbulence and chemistry occurring at the unresolved scales.
280          Pursuit of opportunities to address unresolved scientific questions can help avert future le
281 tor's assessment is that minor issues remain unresolved (see decision letter).
282 tor's assessment is that major issues remain unresolved (see decision letter).
283 olving power by roughly 40-150% and revealed unresolved spectral features.
284 ariabilities in EV isolation methods and the unresolved structural complexity of these biological-nan
285  including DolP (formerly YraP) a protein of unresolved structure and function.
286 ular details of AZ1 inhibition have remained unresolved, stymieing further development of this class
287 erstanding of early development but has left unresolved the balance of risks and benefits to offsprin
288 cks with more extreme ornamentation but left unresolved the question as to why parents show the prefe
289  the nervous system in Cbl deficiency remain unresolved, the Cd320(-/-) mouse provides a unique model
290 h other, how they are resolved and how, when unresolved, they can cause genome instability.
291                                     Chronic, unresolved tissue inflammation is a well-described featu
292                                   It remains unresolved to what extent these exceptional heatwaves, h
293                                              Unresolved topography associated with model resolution c
294 y reaction resulted in a UV-Vis chromatogram unresolved typical of the presence of procyanidins.
295 d some minor, isomeric contributors that are unresolved using conventional ESI-MS/MS.
296                                   It remains unresolved whether increased sarcoplasmic calcium observ
297 ion of activating aerosol particles is still unresolved, with most climate models assuming activating
298   A few interspecific relationships remained unresolved within the multiple-species clade because of
299  structure is fully consistent with previous unresolved X-ray diffraction patterns at 55 GPa.
300 is developed displaying uniform and visually-unresolved yellow colors over a broad range of chromatic

 
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