ライフサイエンスコーパス: unsaturation

1 ficity for C18 fatty acids containing Delta9 unsaturation.

2 Humans also have increased distal marrow fat unsaturation.

3 veal fatty acid chain lengths and degrees of unsaturation.

4 tionalization of C-H bonds with retention of unsaturation.

5 values depend on chain length and degree of unsaturation.

6 s AtSLD2 mutants showed little change in LCB unsaturation.

7 1 and AtSLD2 showed no detectable LCB Delta8 unsaturation.

8 es of natural lipids was set by the level of unsaturation.

9 res that may have one or more sites of chain unsaturation.

10 onic radii and ancillary ligand coordinative unsaturation.

11 s was unaffected by the degree of acyl chain unsaturation.

12 PEs that vary in their degree of acyl chain unsaturation.

13 ng various acyl chain lengths and degrees of unsaturation.

14 i exhibited more variability in locations of unsaturation.

15 conjugated double bonds, and trans-Delta(12) unsaturation.

16 higher than comparable compounds lacking 4,5-unsaturation.

17 damage is a consequence of altered membrane unsaturation.

18 function of their chain length and degree of unsaturation.

19 nt fatty acids differing in chain length and unsaturation.

20 characterized by a high level of fatty acid unsaturation.

21 opsis that have reduced levels of fatty acid unsaturation.

22 further information on acyl-chain length and unsaturation.

23 d with increasing chain length and degree of unsaturation.

24 e to net charge, chain length, and degree of unsaturation.

25 tructural changes associated with acyl chain unsaturation.

26 e C2-position and C2-substituents containing unsaturation.

27 ion function f(theta) varied with acyl chain unsaturation.

28 ult of instability arising from coordinative unsaturation.

29 characterized in relation with the level of unsaturation.

30 obtained with Elev/Temp had lower degree of unsaturation.

31 e of fatty acyl-CoAs with varying length and unsaturation.

32 n, even in the presence of multiple sites of unsaturation.

33 lipid membranes bearing different degrees of unsaturation.

34 nes that differ only in their position(s) of unsaturation.

35 ponent that expressed the variation in lipid unsaturation.

36 utoxidation increased with the degree of oil unsaturation.

37 and hydroxy derivatives with conservation of unsaturation.

38 ing C14 and C16 chains with no more than two unsaturations.

39 pyrrolo ring (saturated or with endo or exo unsaturations), a key feature determining their biologic

40 so active on a C(22) substrate with multiple unsaturations, a result consistent with the role of pero

41 cytotoxic to CLL, and loss of the alpha-beta unsaturation abrogated Nrf2 activity and CLL toxicity.

42 d to be important for several compounds with unsaturation adjacent to the sulfate.

43 for the proposition that, in the absence of unsaturation, an acylium ion acts as a hydride acceptor,

44 ced LOOH transfer included (i) increasing PL unsaturation and (ii) increasing net negative charge imp

45 iophysical experiments have shown that lipid unsaturation and cholesterol both have significant effec

46 Increasing unsaturation and decreasing headgroup size have similar

47 ts and chromatography unveiled the degree of unsaturation and hydroxylation in the ceramide lipid tai

48 sensitively dependent on the degree of chain unsaturation and on the presence of cholesterol.

49 number and size of lipid droplets, and lipid unsaturation and packing order of lipid droplets.

50 lipids varying in their degree of acyl chain unsaturation and polar headgroup size using 1-palmitoyl-

51 ease with the degree of lipid acyl chain cis-unsaturation and reach a plateau with 1-palmitoyl-2-arac

52 Unsaturation and shorter fatty acid length in phospholip

53 Notwithstanding the high SI unsaturation and the commercial antioxidant (TBHQ) in SO

54 Specifically, alkyl chain length, degree of unsaturation and the head group to which the alkyl side

55 d in particular its dependence on acyl-chain unsaturation and the presence of cholesterol.

56 quantitative determination of the degree of unsaturation and transition temperatures of constituent

57 level, and there was a 19% increase in lipid unsaturation and triglyceride levels (P = .027 and P = .

58 group" (defined by carbon number, degree of unsaturation and, in certain cases, degree of branching)

59 unsaturated PCs and the total number of cis unsaturations and acyl chain length (18 to 22) of the un

60 cal stability as a function of the number of unsaturations and molecular branching in the chemical st

61 ber and location of cis and trans fatty acid unsaturations and the absolute stereochemistry of enanti

62 e, charge, reduction potential, coordination unsaturation, and coreactant selectivity.

63 g the PC acyl chain length and the degree of unsaturation, and examined domain formation upon additio

64 thiolation of ketones followed by alpha,beta-unsaturation, and finally the beta-thiolation of alpha,b

65 to obtain the number of carbons, degrees of unsaturation, and location of double bonds, as well as t

66 increasing acyl chain length independent of unsaturation, and modest discrimination between acyl pos

67 n terms of reduction potential, coordination unsaturation, and overall charge associated with the met

68 Quantitation of lipid storage, unsaturation, and oxidation in live C. elegans has been

69 rstand the effect of chain length, degree of unsaturation, and placement of the thia substituent on m

70 ermine the effect of chain length, degree of unsaturation, and stereoisomeric effects of unsaturation

71 on the lipid composition and extent of lipid unsaturation, and that sHsps can regulate membrane fluid

72 Acyl tail length and degree of unsaturation are found to be the primary structural desc

73 ts arising from the presence of the Delta(5)-unsaturation are key controlling elements for the format

74 company changes in the degree of lipid chain unsaturation, are entirely confined to the disordered ph

75 zed amino acids, especially amino acids with unsaturation, are important, demanding building blocks i

76 w field of research, but the large degree of unsaturation as isomers of alkynes (as well as residual

77 egrees C) and also an increased phospholipid unsaturation, as in higher animal models.

78 The new complex shows coordinative unsaturation at one of the Fe(II) centers as the result

79 and fatty acids of various chain lengths and unsaturation at sn-1.

80 us dimer 4 (DSB-120) that lacks substitution/unsaturation at the C2 position elevates melting by only

81 ing structure, and in particular exo or endo unsaturation at the C2-position and C2-substituents cont

82 l compounds, that systematically removed the unsaturation at the N and the chelate character of the l

83 roximately 16% of the energy difference, the unsaturation at the nitrogens accounts for approximately

84 stion generates disaccharides with Delta-4,5-unsaturation at the nonreducing end.

85 a M-C sigma bond and creates a coordination unsaturation at the other metal atom.

86 rs determining CCS magnitude, with degree of unsaturation being four times as influential per mass un

87 troduced at position 5, as well as a unit of unsaturation between positions 3 and 4, with benzoyl or

88 ylene group (i.e., a homologue) or exocyclic unsaturation between the thiazolidine ring and the C3 ca

89 reaction was observed with aldehydes having unsaturation both at terminal and internal positions.

90 ature was increased at lower levels of lipid unsaturation, but the highest temperature was detected f

91 of mixed-chain PE with increasing degree of unsaturation can be interpreted in terms of structural c

92 d acyl chain length and extent of acyl chain unsaturation can now be probed by monitoring the conform

93 icroalgal oils, depending on their degree of unsaturation, can be utilized as either nutritional supp

94 d bilayer properties and composition such as unsaturation, charge, and the presence of reaction produ

95 The degree of acyl chain unsaturation contributed positively to binding strength.

96 the headgroups supports a mechanism by which unsaturation contributes to reduced transition temperatu

97 On the other hand, higher levels of unsaturation decreased bioaccessibility.

98 h the presence of triacylglycerols and their unsaturation degree inhibited cholesterol thermooxidatio

99 The influence of the unsaturation degree of different fatty acids methyl este

100 The influence of the unsaturation degree of different triacylglycerols (trist

101 ffect was further promoted by increasing the unsaturation degree of FAME.

102 tivity largely depends on the length and the unsaturation degree of the hydrocarbon chain.

103 ocessing as well as a small reduction in the unsaturation degree of the lipids.

104 fatty acids with different chain lengths or unsaturation degree on anhydrous milk fat (AMF) crystall

105 The effects of the acyl moiety and its unsaturation degree, and of the sterol structure were in

106 yl groups and this depends not only on their unsaturation degree, but also on the concentration of th

107 disappearance rate of the groups with higher unsaturation degree.

108 m the triacylglycerol was independent on the unsaturation degree.

109 ximum amount decreased with increasing their unsaturation degree.

110 chemical compositions and different varying unsaturation degrees and carbon-chain lengths, together

111 the synthesis of the Ugi adducts, different unsaturation degrees could be obtained in the pyrrolo ri

112 ipid microdomains with a headgroup and chain unsaturation-dependent lipid composition.

113 chain length, and/or increased level of cis unsaturation) destabilize lipoproteins and accelerate th

114 size increases with the extent of acyl chain unsaturation (DOPC:POPC ratio).

115 When assigning sites of unsaturation, E. coli was found to contain all unsaturat

116 we elucidate general trends in bacterial GPL unsaturation elements and thus aim to decipher some of t

117 saturation, E. coli was found to contain all unsaturation elements at the same position relative to t

118 uctural features in bacterial lipids such as unsaturation elements can have vast biological implicati

119 vidual lipid molecules with a high degree of unsaturation exhibited the highest fold changes in mixed

120 synthesis (SQLE), regulation of fatty acids unsaturation (FADS1), cellular cholesterol uptake (LDLR)

121 ion of lipid acyl chain length and degree of unsaturation for a series of phosphatidylcholines.

122 classical concepts that require coordinative unsaturation for catalytic reactions to occur on such su

123 On the basis of the effect of unsaturation for other potent PKC ligands, we would pred

124 energetics of alpha,beta- versus beta,gamma-unsaturation for some common organic functional groups.

125 ions were used to determine the position of unsaturation for some of these species.

126 ecedented influence of the bicyclic backbone unsaturation for the preparation of the corresponding di

127 r ion m/z ratios, chain length and degree of unsaturation for these fatty acids were determined.

128 Increasing acyl chain unsaturation from 18:0,18:1PC to 18:0,22:6PC resulted in

129 n chain length, degree and position of chain unsaturation, head group repulsion, and incorporation of

130 atent source of 5 and this operational "dual unsaturation" highlights the ability of Zn to promote re

131 of various lipid compositions and degrees of unsaturation in a controlled manner.

132 h affinity for fluoride and its coordination unsaturation in aqueous media, which play a key role in

133 For GPLs containing sites of unsaturation in both acyl chains, an MS(3) method was de

134 cholesterol concentration and increased tail unsaturation in brain PM) appear to have opposite, yet c

135 assisted mechanism by promoting coordinative unsaturation in catalytic intermediates responsible for

136 nside a mass spectrometer to assign sites of unsaturation in complex lipids.

137 Increasing the degree of unsaturation in either the sn-1 or sn-2 aliphatic chains

138 sent work, UVPD is used to localize sites of unsaturation in GPL anions.

139 d is a guanosine analogue containing a 2',3'-unsaturation in its planar carbocyclic deoxyribose ring

140 ew silicon species with different degrees of unsaturation in petroleum products.

141 mechanism governing the degree of fatty acid unsaturation in Saccharomyces cerevisiae.

142 ture over the past 5,600 y based on alkenone unsaturation in sediments of two lakes in West Greenland

143 ts are consistent with a role for LCB Delta8 unsaturation in selective channeling of ceramides for th

144 at NIVS can determine the relative degree of unsaturation in six different lipid samples as accuratel

145 Results showed that lipid unsaturation in the axonal layer was significantly incre

146 The presence of unsaturation in the center of the C(10)-alkyl linker pro

147 as expected based on the decreasing level of unsaturation in the fatty acyl chains.

148 s indicative of chain lengths and degrees of unsaturation in the fatty acyl moieties.

149 use is made of the capacity for introducing unsaturation in the furanose sector via phenylsulfenylat

150 lity has a 'propargylic' relationship to the unsaturation in the linker.

151 group, but also by increasing the degree of unsaturation in the lipid tails.

152 he value of the integer being the degrees of unsaturation in the lipid.

153 ositions of the piperidino ring, (2) varying unsaturation in the piperidino C-2 and C-6 substituents,

154 We found that the trans 4,5-unsaturation in the sphingosine backbone promoted closer

155 Yappert and co-workers that trans unsaturation in the vicinity of C4 of the sphingoid back

156 on capacities but high proportions of double unsaturations in response to cold, thanks to regiospecif

157 intramolecular hydroamination of diverse C-C unsaturations, including terminal and internal aminoalke

158 decipher some of the biochemical pathways of unsaturation incorporation in bacterial GPLs.

159 ymerization (excluding decrease of degree of unsaturation) increased significantly as a function of f

160 rd by combining measurements of the alkenone unsaturation index (U37(K)) with non-destructive scannin

161 r temperatures, as observed by a decrease in unsaturation index and 20:5n-3.

162 es to ESI/MS/MS analyses correlated with the unsaturation index and inversely correlated with total a

163 olae/lipid rafts, causing an increase in the unsaturation index in the membrane microdomain.

164 Furthermore, unsaturation index of individuals from the two coldest s

165 The 15.99% increase in the level of unsaturation indicated elevated lipid peroxidation.

166 of MgPzs correlates with the degree of lipid unsaturation, indicating that it is caused by an electro

167 Time series of alkenone unsaturation indices gathered along the California margi

168 Heat stress caused decreases in unsaturation indices of membrane lipids, primarily due t

169 This unsaturation induced structural transformation due to pa

170 ouble bonds per lipid molecule, we find that unsaturations influence mainly the order of the bottom h

171 To explore how PC unsaturation influences the balance between these behavi

172 unsaturation of e (i) In abi1, after taking unsaturation into account, stomatal conductance increase

173 implicate turnover-limiting insertion of C-C unsaturation into the Ln-O bond, involving a highly orga

174 ytic cycle is insertion of the carbon-carbon unsaturation into the Ln-P bond, followed by rapid proto

175 no C-2 and C-6 substituents, (3) introducing unsaturation into the piperidine ring, (4) ring-opening

176 features-an optimal C12-C8 chain length, pi-unsaturation introduction at the corresponding arachidon

177 ly, our findings reveal that increased lipid unsaturation is a metabolic marker for ovarian CSCs and

178 h genetically designed and tunable degree of unsaturation is desirable to maximize process efficiency

179 Unsaturation is essential for the stability and for the

180 nyl beta-amino ketones possessing alpha,beta-unsaturation is exemplified in the total synthesis of th

181 In particular, alpha,beta-unsaturation is favored by less than 1 kcal/mol for the

182 itration at the 9 or 10 olefinic carbon, and unsaturation is required for XOR inhibition.

183 The degree of unsaturation is unified by selective heterogeneous hydro

184 skin oil, which contains substantial carbon unsaturation, is likely to occur rapidly under common cl

185 The N-acyl heterogeneity, including unsaturation, is localized mainly to the proximal glucos

186 on rate and selectivity vary with substrate unsaturation: larger metal ions and more open ligand sys

187 the substrate by incorporating an alpha,beta-unsaturation led to the discovery of a tandem cyclizatio

188 licable to many natural fats and oils of low unsaturation level assisting advanced investigation of l

189 The unsaturation level of the fluid-phase component was vari

190 Interestingly, the effect of unsaturation level on the dynamics of vesicles undergoin

191 d lipidome hallmarks-lipid concentration and unsaturation level, cis/trans isomer ratio, sphingolipid

192 Our results suggested that decreasing lipid unsaturation levels by lowering 18:3 fatty-acid amount t

193 Higher lipid unsaturation levels were also detected in CSC-enriched s

194 e mapping of fat distribution, degree of fat unsaturation, lipid oxidation, and cholesterol storage i

195 ination of isomers that differ in site(s) of unsaturation, methyl branching or cyclopropanation.

196 sible, despite the latter having a degree of unsaturation more similar to olive oil than to sunflower

197 levels in the BRCA2 cohort showed increased unsaturation of 21% (P = .030) relative to triglycerides

198 ying the number of carbons and the degree of unsaturation of any acyl-chain substituents.

199 Greater unsaturation of both substrate and non-substrate lipids,

200 f this study was to examine how the enhanced unsaturation of CH2=C=X compared to that of CH3CH=X may

201 to increasing VPD was pivotal in preventing unsaturation of e (i) In abi1, after taking unsaturation

202 n wild-type leaves, there was no evidence of unsaturation of e (i), even at VPD above 6 kPa.

203 om which the carbon number and the degree of unsaturation of each acyl group are obtained.

204 es in both carbon chain length and degree of unsaturation of fatty acid substituents, particularly in

205 Degree of unsaturation of fatty acids affects physical properties

206 r high antioxidant capacity and the level of unsaturation of fatty acids.

207 ependent on their composition instead of the unsaturation of fatty acids.

208 ow and used to evaluate profiles of sites of unsaturation of lipids in Escherichia coli (E. coli) and

209 d as being causally linked to changes in the unsaturation of membrane phospholipids, yet in animals t

210 presence of both the PE headgroup per se and unsaturation of the 1,2 fatty acids.

211 Increased unsaturation of the acyl or steryl moiety of steryl este

212 or zeta-aryl carbonyl compounds, because the unsaturation of the alkene is relayed to the alcohol, re

213 membrane bilayer including (1) the degree of unsaturation of the fatty acid guest and the regiospecif

214 rbate/Fe(III)/O(2)] depends on the degree of unsaturation of the fatty acid.

215 duct ion ratio is dependent on the extent of unsaturation of the fatty acyl group at sn-2 as well as

216 Coordinative unsaturation of the Fe(II) in the presence of both cosub

217 f the cationic head group, (2) the degree of unsaturation of the hydrophobic tail, and (3) the presen

218 weight reduction with no change in the total unsaturation of the molecule (or Z-number as in chemical

219 r whereby cis-double bond geometry and alpha-unsaturation of the native substrate are important featu

220 chain-transfer reaction yields the terminal unsaturation of the polymer.

221 ntibiotic activity on the size and degree of unsaturation of the precursor.

222 sidic linkage of the substrate chain and the unsaturation of the product.

223 trometry, there was no compensatory shift in unsaturation of the PtdEtn and PtdPrn toward more bilaye

224 torsional angles between different planes of unsaturation of the retinal chromophore.

225 uded removal of C-19 (19-nor); each also had unsaturation of the side chain.

226 mics increased in mixed-chain species as the unsaturation of the sn-2 chain was increased.

227 s coupled with a 33% decrease in the average unsaturation of the sphingolipids resulted in a phosphol

228 e fashion, despite the significant degree of unsaturation of the substrates.

229 inds with a superior affinity to lipids with unsaturation on both alkyl chains.

230 The influence of hydrocarbon chain unsaturation on Ca(2+) binding is secondary compared to

231 ly relate our results to the impact of chain unsaturation on the interaction of the fluid-phase lipid

232 unexpected influence of the degree of lipid unsaturation on the orientation of the SNARE complex.

233 unsaturation, and stereoisomeric effects of unsaturation on the oxidation of individual fatty acids

234 The effects of membrane lipid unsaturation on the partitioning of alamethicin were als

235 location of both double bond and cyclopropyl unsaturations on the four acyl chains of CLs.

236 of lipid membranes and highlight the role of unsaturations on their physical and chemical properties.

237 Varied degrees of unsaturation (one double bond, NSenB; two double bonds,

238 The degree of unsaturation or conformation of double bond appears to h

239 lipid isomers that differ only in site(s) of unsaturation or geometric configuration of the carbon-ca

240 ycloaddition reaction, the overall degree of unsaturation (or oxidation state) of the 4pi (diene) and

241 3 fatty acid metabolism, including degree of unsaturation (P=1.16x10(-)(34)), levels of polyunsaturat

242 lability of appropriate levels of fatty acid unsaturation, partially compensating the antilipogenic e

243 significant promise for facile profiling of unsaturation patterns within complex lipidomes including

244 s composed of phospholipids containing a cis unsaturation per acyl chain (DO and DPe), while transbil

245 Importantly, the presence of the unsaturation plays a dominant role in the arrangement of

246 PC), a lipid possessing a single acyl chain unsaturation point, yields the highest abundance of the

247 The unsaturation present in the (E)-methyl-pent-3-enoate sid

248 The utility of the 2,3-unsaturation present in the resulting glycoside is demon

249 ond one was highly affected by the degree of unsaturation, PUFA being the fatty acids that showed the

250 of sea surface temperature based on alkenone unsaturation ratios in sediments of the Bermuda Rise pro

251 The compounds lack the olefin unsaturation required for potency in the natural ligand

252 eral domains, which are cholesterol-rich and unsaturation-rich, respectively.

253 In all cell lines, pentamines that had unsaturation(s) at the end of the chain showed the highe

254 The pentamines with unsaturation(s) at the end of the chain were once again

255 However, the unsaturation seems to be compensated by a weak M-C(arene

256 atty acid chain lengths and degrees of chain unsaturation showed a range of membrane affinities (5.8

257 separation allowed assignment of the native unsaturation sites.

258 Fatty acid desaturases regulate the unsaturation status of cellular lipids.

259 sight into the interplay of fatty acid chain unsaturation, sterol concentration, and lipid hydrophobi

260 lic and physiological significance of Delta8 unsaturation, studies were performed using mutants of th

261 ted lipids or lipids with a modest degree of unsaturation, substantially larger pK(a) shifts are obse

262 g acyl chain length and decreasing degree of unsaturation, such that N-lauroylethanolamine and N-myri

263 r of potency correlated with their degree of unsaturation, suggesting that AA directly stimulates the

264 (O(2) C(C(7) HX)) with different degrees of unsaturation, supported on silver (Ag(TS) ) bottom elect

265 ylcholine had a significantly lower level of unsaturation than phosphatidylcholine in the remainder o

266 Notably, this approach tolerates substrate unsaturation that normally poses major challenges in che

267 chosen with 18 carbon chains and degrees of unsaturation that ranged from one double bond (C18:0/1,

268 The degree of fatty acid unsaturation, that is, the ratio of unsaturated versus s

269 spholipids differ significantly in length or unsaturation, the behavior is markedly different.

270 pending on temperature and hydrocarbon chain unsaturation, the lipid with the highest chain melting t

271 lysed strongly depended on the degree of oil unsaturation; the two least unsaturated oils with low co

272 h an acetate ester functional group, and 1-3 unsaturations, there are 1039 isomers.

273 a pathway for the generation of coordinative unsaturation, thereby enabling ligand substitution and/o

274 up, but differ in their alkyl tail length or unsaturation; these differences are expected to affect t

275 on of the importance of chloroplast membrane unsaturation to the proper growth and development of pla

276 n and promotes the migration of the alkene's unsaturation toward the alcohol to ultimately form the k

277 ig1/SREBP1 and preserves the degree of lipid unsaturation under conditions of obesity-induced insulin

278 ng even terminal alkynes (and other sites of unsaturation) untouched.

279 g substantially increased metal coordinative unsaturation vs the corresponding Me2SiCp' '2AnR2 (Cp' '

280 Barton-McCombie reaction, and the alpha,beta-unsaturation was achieved through selenylation and oxida

281 the first carbon participating in a site of unsaturation was consistently seven carbons along the ac

282 Finally, the position of unsaturation was determined using reactive paper spray i

283 The C14,15 unsaturation was installed late in the synthesis by an o

284 Unsaturation was introduced at Delta(4,6) and Delta(6) o

285 The degree of unsaturation was lower in visceral adipose tissue (VAT)

286 aturated rhodium complexes; the coordinative unsaturation was stabilized by the site isolation of the

287 el production with a wide range of degree of unsaturation were created, in which proportion of SFAs,

288 y acid chain lengths with varying degrees of unsaturation were found to support binding to radiolabel

289 differing in acyl chain length and degree of unsaturation were potent inhibitors of the well-characte

290 imido-substituted furans containing tethered unsaturation were prepared by the addition of the lithiu

291 ethylthio)-5-amidofurans containing tethered unsaturation were prepared via the reaction of dimethyl(

292 ethylthio)-5-amidofurans containing tethered unsaturation were prepared via the reaction of dimethyl(

293 Independent of the chain length unsaturations were highly elevated with one to two doubl

294 lipids, varying in headgroup and acyl chain unsaturation, were studied by measuring the partition co

295 llustrating the effect of introducing C2-exo-unsaturation which serves to flatten the C-rings and ach

296 active three-membered rings substituted with unsaturations with a particular focus on vinylcyclopropa

297 hospholipid vesicles with varying acyl chain unsaturation, with and without cholesterol.

298 shown great utility for localizing sites of unsaturation within acyl chains and to date has predomin

299 viously unknown susceptibility of lipid mono-unsaturation within de-differentiated mesenchymal cells

300 size, the effect of methyl substitution, and unsaturation within the macrocyclic ring structure were