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1 ial lifestyle decisions by binding to the 5' untranslated and/or early coding regions of mRNA targets
2 transcript level through alternate use of 5' untranslated exons (UTRs), promoters, and proinflammator
3 e protein, of which one is located in the 5'-untranslated leader and the other is within the coding s
7 ng noncoding RNAs, small nucleolar RNAs, and untranslated mRNA regions, accomplish many of their dive
8 d that these sRNAs are processed from the 3' untranslated region (3' UTR) of the oppABCDF and carAB o
10 ore, we identified 16,342 isoforms in the 3' untranslated region (3' UTR), 2640 of which are novel an
11 th miR-195 and CUGBP1 interacted with the 3' untranslated region (3'-UTR) of Igf2r mRNA, and the asso
12 the ribosomal frameshift segment and the 3'-untranslated region (3'-UTR) of the SCoV2 genome, their
19 radation rates based on the output gene's 3'-untranslated region (3'-UTR): introduction of copies of
21 nts of peripheral sensory neurons and the 3' untranslated region (3'UTR) landscapes after unilateral
22 Herein we show the importance of 3 prime untranslated region (3'UTR) non-coding regulatory varian
23 iR-15a/16-1 cluster directly bound to the 3' untranslated region (3'UTR) of Claudin-5, and lentivirus
24 s via binding the AU-rich elements of the 3' untranslated region (3'UTR) of numerous pro-inflammatory
25 to identify microRNAs that would bind the 3' untranslated region (3'UTR) of occludin mRNA; regions th
27 an expansion of a (CTG)n tract within the 3' untranslated region (3'UTR) of the dystrophia myotonica
28 or the fine-tuning of gene expression via 3'-untranslated region (3'UTR) targeting, and we have previ
29 d by miR-21 through distinct sites in its 3' untranslated region (3'UTR), and miR-21 expression in CR
30 led by alternative polyadenylation in the 3' untranslated region (3'UTR), with critical physiological
34 A genomes share a long, highly structured 5' untranslated region (5' UTR) containing a type I interna
35 e demonstrate that ATXN1's unusually long 5' untranslated region (5' UTR) negatively regulates its ex
36 dies have identified several sites in the 5' untranslated region (5' UTR) of HIV-1 RNA that are bound
37 ured iron-responsive element (IRE) in its 5' untranslated region (5' UTR) that controls its translati
38 out this region of the genome, called the 5' untranslated region (5' UTR), is needed to assist in the
41 ome binding or subsequent scanning of the 5'-untranslated region (5'-UTR) for the AUG initiation codo
42 5'-flanking region containing the 263 bp 5'-untranslated region (5'-UTR) including the first intron.
43 le-nucleotide polymorphisms (SNPs) in the 5' untranslated region (5'-UTR) of the ferritin light chain
44 eature alternative splicing events in the 5'-untranslated region (5'-UTR) that are favorable for tran
48 dcd4 regulates Sin1 translation, the SIN1 5' untranslated region (5'UTR) was fused with luciferase re
50 ext suppressed Bdnf transcripts with long 3' untranslated region (L-3'-UTR) using short hairpin RNA a
51 74 strain lacking 30 nucleotides from its 3' untranslated region (rDEN2Delta30) has previously been e
52 among which 23.5% and 5.4% were located in 5 untranslated region (uPSS) and intergenic region (iPSS),
53 ences the translation of RhlI through its 5'-untranslated region (UTR) and identified that the sRNA P
54 ent, deep-sequencing method targeting the 5' untranslated region (UTR) and P1 genomic region to chara
55 r translational enhancer sequences in the 5' untranslated region (UTR) and rare codons at the beginni
56 TTP targets AU-rich elements in the NLRP3 3'-untranslated region (UTR) and represses NLRP3 expression
57 e that interrogates only the junctions of 3'-untranslated region (UTR) and the poly(A) tails at the t
59 SLA) and stem-loop B (SLB) located in the 5' untranslated region (UTR) are critical for binding the v
60 t have complex secondary structure in the 5' untranslated region (UTR) are translated more efficientl
62 regulated by structural complexity of the 5'untranslated region (UTR) derives from bacterial and oth
63 of CaMKII mRNA, which consists of a short 3'-untranslated region (UTR) form lacking regulatory elemen
66 inds to a U-rich element in the STAT3 mRNA-3'untranslated region (UTR) located within the vicinity of
67 roRNA 33a and 33b (miR-33a/b) bind to the 3' untranslated region (UTR) of ABCA1 and repress its postt
68 at predicts the protein expression of the 5' untranslated region (UTR) of mRNAs in the yeast Saccharo
70 esence of a G-quadruplex structure in the 5' untranslated region (UTR) of NRF2 mRNA, as measured by c
71 validated the miR-744 binding site in the 3' untranslated region (UTR) of PELI3 and demonstrated that
72 ly binds to single-stranded motifs in the 3' untranslated region (UTR) of RNA that contain a UAG trin
73 ation of the promotor region, the 5'- and 3'-untranslated region (UTR) of SAMHD1, and the mechanism r
75 at expansion [r(CUG)(exp)] located in the 3' untranslated region (UTR) of the dystrophia myotonica pr
77 erozygosity for a frequent variant in the 3' untranslated region (UTR) of the mutant allele, which di
78 ss of suppressors was found to map to the 5' untranslated region (UTR) of the rplM-rpsI operon, which
80 othesized that unpaired guanosines in the 5' untranslated region (UTR) play an important role in Gag:
82 leotide polymorphisms (SNPs) in the HLA-G 3' untranslated region (UTR) regulate HLA-G expression, we
83 selenoproteins by a mechanism involving a 3 untranslated region (UTR) selenocysteine insertion seque
85 lternative polyadenylation (APA)-mediated 3'-untranslated region (UTR) shortening is known to increas
86 acterial type I toxin mRNAs possess a long 5 untranslated region (UTR) that serves as the target site
87 ermed 'regulation elements (RgE)', in the 5'-untranslated region (UTR) to impact translation efficien
88 protein coding regions and one SNV in the 5' untranslated region (UTR) were identified and provided a
90 eraction of miR-485-5p within the UGT2B10 3'-untranslated region (UTR), and significant reduction in
91 vy polysomes, probably through the TCF7L2 5'-untranslated region (UTR), as determined by polysome fra
92 (SbCAD2) that has an 8-bp deletion in its 5'-untranslated region (UTR), conferring the spontaneous br
93 Stem-loop A (SLA), a part of the viral 5' untranslated region (UTR), is critical for the initiatio
94 -4.8 kcal/mol) in the middle of the mRNA 5' untranslated region (UTR), our assay robustly detects sm
95 rectly to an (AAN)3 motif within the mutS 5' untranslated region (UTR), repressing translation in the
96 hanged when the intron was located in the 5'-untranslated region (UTR), suggesting that the intron af
97 946a is predicted to bind to the TGFbeta1 3' untranslated region (UTR), thereby inhibiting its transc
98 Through deletion mutations of the TriMV 5' untranslated region (UTR), we show that the TriMV 5' UTR
99 ver-specific miR-122 binds within the HCV 5' untranslated region (UTR), whereas the broadly expressed
100 and miR-58 family miRNAs within the egl-1 3' untranslated region (UTR), which affect both mRNA copy n
105 conserved between virus strains (ie, the 5'-untranslated region and cis-acting replication element)
106 of BCL2 mRNA through AU-rich elements in 3'-untranslated region and consequentially increased BCL2 p
107 ctly interacted with Atg16l1 mRNA via its 3' untranslated region and enhanced ATG16L1 translation, wi
109 e novel including a deletion spanning the 5' untranslated region and the first coding part of exon 1.
110 ts specific to sigma (sigma) factors, and 5'-untranslated region as a determinant for translation eff
111 h have acquired an extra 6 bases in the long untranslated region between the M and F protein coding s
114 ith m(6) A modification of the FOXO3 mRNA 3'-untranslated region increasing its stability through a Y
115 d a strain-specific +59 motif in the cagA 5' untranslated region influence the levels of cagA express
117 cis-acting sequence variants in the FAD2 5' untranslated region intron that determine the expression
118 tic production of CaMKII mRNA with a long 3'-untranslated region is necessary for modulating spontane
121 med by a dose-dependent reduction in HCN4 3'-untranslated region luciferase reporter activity on cotr
123 NA-dependent RNA polymerase to recognize the untranslated region of a genome segment of a related phl
124 with corresponding barcodes placed at the 3' untranslated region of a reporter gene using a lentivira
125 ly repressed by p21, directly targets the 3' untranslated region of adenosine monophosphate-activated
127 a direct interaction of miR-181c with the 3' untranslated region of ATM, and the presence of ATM in m
129 IP3 interacted with the AU-rich region in 3' untranslated region of Cyclin D1 mRNA and stabilized it.
132 P of highest significance occurred in the 3' untranslated region of gig1, a fish-specific antiviral e
134 iferase reporter assay confirmed that the 3'-untranslated region of IGFBP1 mRNA is targeted by miR-54
135 d DNA methylation within the promoter and 5'-untranslated region of Kcna2 gene, rescued Kcna2 express
136 2.5-kb deletion (del2.5) overlapping the 3' untranslated region of LDLR in 7 heterozygous carriers f
137 e also identified different motifs in the 3' untranslated region of messenger RNAs that were sex diff
138 y the translation of reporters containing 3' untranslated region of Mos or Ccnb1 and the accumulation
139 uR binding to AU-rich elements within the 3' untranslated region of mRNAs encoding oncogenes, growth
140 RBP lupus antigen (La) interacts with the 3'-untranslated region of PDCD4 mRNA and prevents miR-21-me
142 iferase reporter assay indicated that the 3' untranslated region of PTPRJ was targeted by this miR.
143 ed N6-methyladenosine modification in the 5'-untranslated region of some highly translated mRNAs.
145 open reading frame (uORF) present in the 5' untranslated region of the Arabidopsis (Arabidopsis thal
150 ns with a reporter plasmid containing the 3' untranslated region of the gene encoding ERalpha (ESR1)
151 an expansion of a GCA-repeat tract in the 5' untranslated region of the gene encoding glutaminase (GL
152 o DNA methylation within the promoter and 5'-untranslated region of the Kcna2 gene, reductions in Kcn
153 coding sequence (CDS) base pairs with the 5' untranslated region of the mRNA to sequester the ribosom
157 We introduced modifications within at the 5' untranslated region of the Sabin2 genome to stabilize at
159 p-independent translation element) in the 3' untranslated region of the viral RNA genome that allows
160 ne candidates containing deletions in the 3' untranslated region of the Zika virus genome (ZIKV-3'UTR
161 contains a 10-nucleotide deletion in the 3' untranslated region of the ZIKV genome (10-del ZIKV).
162 t by binding to specific sequences in the 3' untranslated region of their target genes and causing th
164 ificant association between 2 SNPs in the 3' untranslated region or within the adjacent region just 3
166 t binding sites within stem-loop 1 of the 5' untranslated region play important roles in genome packa
167 in an 250 kb haplotype block spanning the 5' untranslated region region of insulin-degrading enzyme i
169 ependent translation element (BTE) in the 3'-untranslated region that interacts with host translation
170 3(EGLN3) gene and targeted a site in its 3'-untranslated region to downregulate its transcriptional
171 identified a novel intron within the LANA 5' untranslated region using a splice acceptor at 127888.
172 e targeted the PTEN proximal promoter and 5' untranslated region with dCas9 fused to the repressor pr
173 e expression of CD24 by targeting its 3'UTR (untranslated region) and could be inhibited by SIRT1 via
175 capsid structural proteins as well as the 3' untranslated region, each attenuated virus possessed a d
176 alternative splicing of its terminal exon 3' untranslated region, generating an oncogenic, C-terminal
177 of the miR-223 binding site in the NLRP3 3' untranslated region, phenocopied the characteristics of
178 the RNA-binding protein Raly and the CCR5 3' untranslated region, protecting CCR5 messenger RNA from
179 no loss of attenuation in domain V of the 5'-untranslated region, the primary site of reversion in Sa
180 ) through a targeting sequence at the sty 3' untranslated region, thereby enhancing MAPK signaling an
181 nical upstream open reading frames in its 5' untranslated region, which is bypassed in MYC(Tg);KRAS(G
182 s in the miR-33 binding sites of the Abca1 3'untranslated region, which prevents targeting by miR-33.
195 rporating a rbcS gene whose codon use and 5' untranslated-region matched rbcL Additional tobacco geno
196 RBPs that we subject to luciferase-based 3'-untranslated-region tethered function assays to pinpoint
198 Wu et al characterized small ORFs in the 3' untranslated regions (3' UTRs) of human and zebrafish mR
203 -310s bind to target binding sites in the 3' untranslated regions (3'-UTR) of both Cyp6g1 and Cyp6g2
204 mouse and human MOR-1Bs that defines the 3'-untranslated regions (3'-UTR) of MOR-1Bs and stabilizes
207 ng reporter assays have demonstrated that 3' untranslated regions (3'-UTRs) regulate gene expression
208 lyadenylation may result in expression of 3'-untranslated regions (3'-UTRs) with varying lengths.
210 cells have widespread shortening of mRNA 3'-untranslated regions (3'UTRs) and switches to shorter mR
211 A) generates mRNA isoforms with different 3' untranslated regions (3'UTRs) and/or coding sequences.
214 polyadenylation (APA) produces transcript 3' untranslated regions (3'UTRs) with distinct sequences, l
215 hesis by engineering sequence elements in 5' untranslated regions (5' UTRs) remains a fundamental cha
216 ) site usage within the coding region and 5' untranslated regions (5'-UTRs), and the lack of FIP1 act
218 tiple isoforms characterized by different 5' Untranslated Regions (5'UTRs), whereby translation of a
221 y causative of human diseases, especially in untranslated regions (UTRs) and noncoding RNAs (ncRNAs).
223 we show that WT1 binds preferentially to 3' untranslated regions (UTRs) of developmental targets.
224 lation of E2F1 and E2F3 mRNAs through the 5' untranslated regions (UTRs) of E2F1 and E2F3 (E2F1/3) mR
225 G-quadruplex (G4) sequences are abundant in untranslated regions (UTRs) of human messenger RNAs, but
226 stream open reading frames (uORFs) across 5'-untranslated regions (UTRs) of key signalling components
230 to unwind RNA secondary structure in the 5'-untranslated regions (UTRs) of mRNAs to promote their re
231 epression mechanisms targeting the 5' and 3' untranslated regions (UTRs) of utrophin mRNA significant
233 filing of a library of 280,000 randomized 5' untranslated regions (UTRs) with deep learning to build
234 s with polyadenylated 3' ends that map to 5'-untranslated regions (UTRs), introns, and protein-coding
239 oroplast-specific parts (47 promoters, 38 5' untranslated regions [5'UTRs], nine promoter:5'UTR fusio
240 ntragenic transcripts, leaderless RNAs, long untranslated regions and a unique nucleotide frequency f
241 orly translated, low-stability mRNAs, the 5'-untranslated regions and coding regions of which are enr
242 ourth of these pause sites were localized to untranslated regions and could participate in posttransc
243 s replicate between brain regions, map to 3'-untranslated regions and intronic regions, share common
244 insertion sites are within genes (including untranslated regions and introns) and 28% (7217) are wit
245 resistant allele YrAS2388R has duplicated 3' untranslated regions and is characterized by alternative
246 mRNA-specific activators that bind to the 5' untranslated regions and promote translation on mitochon
247 oplast mRNAs harbor putative SDs in their 5' untranslated regions and the aSD displays strong conserv
248 were due, in part, to variably annotated 3' untranslated regions and thousands of gene models missin
249 e Pax3 messenger RNA that differ in their 3' untranslated regions are differentially susceptible to r
250 ings unveil a role for the translation of 5' untranslated regions in cancer, and expose new targets f
251 ters, origins of replication, telomeres, and untranslated regions in mRNA, suggesting roles in modula
253 revealed that PSPC1 binds to intronic and 3'-untranslated regions of a number of adipocyte RNAs, incl
254 am open reading frames (uORFs) within the 5' untranslated regions of annotated coding genes and 354 s
258 inds in a sequence-specific manner to the 3' untranslated regions of many proinflammatory mRNAs and r
259 anscriptional riboswitches located in the 5'-untranslated regions of messenger RNA requires the tempo
260 trinucleotide motif predominantly in the 3' untranslated regions of mRNA, and destabilizes target mR
262 utations in the 5' region of TP53, in the 3' untranslated regions of NFKBIZ and TOB1, focal deletions
264 nal activators are believed to act on the 5'-untranslated regions of target mRNAs, but the molecular
265 h-affinity binding to AU-rich elements in 3' untranslated regions of target mRNAs, mediated through i
267 ent translation enhancers (3'CITE) in the 3' untranslated regions of their genomic (g)RNAs to compete
270 binds to AU-rich elements present in the 3' untranslated regions of transcripts that mainly encode p
272 n RNase MRP and 2 bacterial messenger RNA 5' untranslated regions reveals functionally important and
273 positioning around splicing signals and mRNA untranslated regions that associate with distinct RBP fu
274 y sites (IRES) are segments of mRNA found in untranslated regions that can recruit the ribosome and i
275 anslation of viral or reporter mRNAs with 5' untranslated regions that contain adenosine repeats, so-
276 The large majority of TISs that mapped to 5' untranslated regions were noncanonical and led to N-term
277 hing genes displayed global shortening of 3' untranslated regions with increased expression in indica
279 ng allows the translation of host and viral "untranslated regions" (UTRs) to create N-terminally exte
280 the gene (enhancer, promoter, and 5' and 3' untranslated regions) account for the majority of activi
281 revealed the landscapes of gene structures, untranslated regions, and splicing activities to be more
282 ering studies of transcriptional regulation, untranslated regions, genome engineering, and expression
283 tly improve the annotations of P. vivax gene untranslated regions, providing an important resource fo
284 ta was used to define thousands of 5' and 3' untranslated regions, some of which overlapped with neig
285 are a major class of cis elements within 3' untranslated regions, targeting these mRNAs for rapid de
290 synthesis from non-canonical translation of "untranslated" regions and non-AUG start codons and sensi
291 We show here that a short-complementarity untranslated RNA (scoutRNA), together with crRNA, is req
292 the relative proportions of intronic/exonic/untranslated RNA captured by RNA-seq for most genes.
294 SPR array transcripts are unusually long for untranslated RNA, suggesting the existence of mechanisms
297 used to screen thousands of untranscribed or untranslated sequences and their variants for functional
298 regions including promoters, terminators and untranslated sequences could drive stable luciferase tra
300 ules, and during stress, when most mRNAs are untranslated, the composition of P-bodies reflects this