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1 the S phase when their expression is highly upregulated.
2 noids and L-phenylalanine were most strongly upregulated.
3 only, one of the four GH5 genes was strongly upregulated.
4 TEIN (PR) genes that were 100- to 1,000-fold upregulated.
5 ubular epithelial cells and time-dependently upregulated.
6 r members of the cytochrome P450 family were upregulated.
7 le defense responses and PPAR signaling were upregulated.
8 120ctn inactivation, Twist2 is significantly upregulated.
12 as a driving mechanism for cell protrusion, upregulated actin polymerization alone does not initiate
14 tudy, we found that glutamine metabolism was upregulated after EGFR activation in a GDH1 (glutamate d
15 interleukin (IL)-1beta and IL-6 is markedly upregulated after heart allotransplantation and lymphoab
18 or and type 1 interferon receptor signaling, upregulated an IRF8-dependent maturation module, and acq
20 d 4,720 downregulated genes in UF, and 2,560 upregulated and 1,762 downregulated genes in RF under fu
22 of these, 143 transcripts were significantly upregulated and 17 transcripts were repressed under HS c
24 from non-treatment studies and 547 DEGs (133 upregulated and 414 downregulated) from treatment studie
25 ns IFN-gamma production by CD4(+) T cells is upregulated and is associated with inflammatory polariza
26 s have shown that in solid tumors, IGFBP2 is upregulated and promotes several key oncogenic processes
27 n p21 signal transduction, was significantly upregulated and represents a novel mechanism for hormone
28 and in vivo in SIVmac-infected macaques, by upregulating antioxidant pathways and the intertwined ir
29 TNF-alpha plays a pivotal role in the LPS-upregulated astrocyte activation and proliferation, supp
30 The SLCO2A1 and CYP1A1 genes, which were upregulated at the forearm of nonhealers, were mainly ex
31 Here, we report how Runx1 is specifically upregulated at the injury site during zebrafish heart re
32 e migration and invasion, were significantly upregulated at the intra and extracellular proteomes sug
35 esistin-injected normal chow-fed mice showed upregulated blood glucose level by increasing gluconeoge
36 integrate hedgehog activation signalling to upregulate BMP antagonism in the progenitor niche that p
39 expressed genes previously identified to be upregulated by activated microglia during aging, neurode
40 ACE1), the key-enzyme of amyloidogenesis, is upregulated by cerebrovascular insult; moreover, its act
43 screens reveal that ATP7A, a copper-exporter upregulated by mutant KRAS, is essential for neoplastic
44 sion of ABCE1, a translation factor directly upregulated by N-MYC, is itself a strong predictor of po
47 ompare the spectrum of inflammatory proteins upregulated by pro- and anti-inflammatory IL-2C treatmen
48 In plants, as in other organisms, sHSPs are upregulated by stress and are proposed to act as molecul
50 clude that PPP2R2A deficiency elevates RS by upregulating c-Myc activity, rendering cells reliant on
52 ced fatty acid availability and a failure to upregulate carbohydrate metabolism, essentially starving
54 gen fibrillogenesis in a turbidity assay and upregulates cell-mediated collagen compaction and reorga
55 n affected LN structure with increased HEVs, upregulated chemokines, and cell adhesion molecules, and
56 ngs demonstrate that aberrantly activated SE upregulates CHPT1 expression and confers Enz resistance
57 w-immunogenic tumor model, DNA demethylation upregulates cryptic transcript expression in a HIF-depen
59 ckdown limited the ability of RvD5n-3 DPA to upregulate cyclic adenosine monophosphate, phagocytosis
60 activated cells gain cytolytic potential by upregulating cytotoxic effector proteins and IFN-gamma.
61 the formation of invasive leader cells with upregulated Delta-like ligand 4 (DLL4) expression as wel
63 ay that maintains cellular homeostasis(2)-is upregulated during exercise, and a core autophagy protei
64 is highly specific for activated T cells, is upregulated during GvHD, and mediates disease pathogenes
65 ependent antiapoptotic proteins specifically upregulated during HCMV infection but not during growth
67 ression and plasma membrane localization are upregulated during hypertension induced by angiotensin I
68 identify B. thetaiotaomicron genes that were upregulated during Salmonella-induced gut inflammation a
69 thermore, we identify Sox17 as a critical TF upregulated during the sprouting and remodeling of coron
73 Our study provides a mechanism whereby ADT upregulates EGFR-LIFR signaling that activates SUCLG2, w
75 violates our predictions, it is adaptive to upregulate encoding of novel information, while down-wei
78 tural non-productive alternative splicing to upregulate expression from wild-type or hypomorphic alle
80 found that mutants CDC-9 P28 and P44 induced upregulated expression of immunomodulatory cytokines.
84 uring vs outside episodes were significantly upregulated for IFN-y (ratio 1.73), TNF-alpha (ratio 2.0
87 accompanied by a failure of numerous PSCs to upregulate galectin-3 (MAC-2), a marker of glial axonal
89 omparison to controls, DPSC-CM significantly upregulated gene expression of several neuronal markers
91 n contact with their respective promoters to upregulate genes involved in local protein translation i
93 own and TGFbeta1 signaling revealed 1,584 co-upregulated genes and 1,280 co-downregulated genes, incl
95 lation, hormone synthesis, and angiogenesis; upregulated genes were associated with inflammation.
97 the interferon regulatory factor IRF5, which upregulates genes encoding guanylate-binding proteins (G
98 PRDM14 cooperates with TFAP2C and BLIMP1 to upregulate germ cell and pluripotency genes, while repre
99 Upon FGF21 signaling, JMJD3 epigenetically upregulates global autophagy-network genes, including Tf
101 me bioenergetic measurement and metabolomics upregulated glycolysis and suppressed oxidative phosphor
102 rtantly, upon glucose limitation, Vitamin K2-upregulated glycolysis markedly induced metabolic stress
103 malized the intracellular NADH:NAD(+) ratio, upregulated glycolytic ATP production and restored cellu
104 ggest that hypoxia induces renal fibrosis by upregulating HE4 and activating the HIF-1alpha/HE4/NF-ka
105 contributes to electric remodeling in AF by upregulating I(KACh) by a mechanism involving frequency-
106 wever, overexpression of IKZF3 was unable to upregulate IL-10 at the mRNA or protein level in CD4(+)
107 turn, IFN-gamma released by Vdelta2(+) cells upregulates IL-12 secretion by DCs in a positive feedbac
108 etraosylceramide (Gb4Cer), are significantly upregulated in about half of the human colorectal carcin
109 mediators (IL-10 and FOXP3) were comparably upregulated in all groups, without displaying the severi
115 serotonin transporter (SERT) expression was upregulated in both DRN projection fields of male mice b
116 otein-coupled receptor for lactate, which is upregulated in breast cancer and plays an autocrine role
117 Mesenchymal markers snail and MMP14 were upregulated in cancer cells maintained in 3D (P < 0.001)
118 , an oncogenic transcription factor commonly upregulated in cancer, is in many cases not due to genet
119 Importantly, the MMEJ pathway is commonly upregulated in cancers, especially in homologous recombi
120 ygen species scavenger glutathione (GSH) was upregulated in chRCC due to decreased expression of prot
122 gation revealed that IFN pathway was grossly upregulated in clinical AD and significantly correlated
123 affinity IL-18 decoy receptor, is frequently upregulated in diverse human and mouse tumours and limit
125 on, migration, and invasion and are markedly upregulated in GBM and many other infiltrative cancers.
127 In the validation cohort, inflammation was upregulated in HFpEF cases versus controls, and the most
129 lncRNA, named GABPB1-AS1, was significantly upregulated in HPV16-positive CC tissues and cell lines.
130 Here, we identify lncRNA LUCAT1 which is upregulated in human myeloid cells stimulated with lipop
134 channels enhance migration and invasion when upregulated in leading edges of certain classes of cance
135 ; and (iii) a number of S1 and S2 genes were upregulated in leucaena under iron-deficiency condition
138 t of endogenous retroviral element RNAs were upregulated in metastatic cells and detected extracellul
139 c, and mural cell markers were significantly upregulated in miniature pig TMJ tissues relative to don
140 dds GGTTAG repeats to chromosome ends and is upregulated in most human cancers to enable limitless pr
143 e find that transcriptional cofactor HOPX is upregulated in mouse models and in human YAP1-fusion ind
145 ncoded complex V subunits, were unchanged or upregulated in mutator mitochondria, suggesting a robust
146 anulin (Grn) as osteocytic-secreted proteins upregulated in Ocy454-Gsalpha(KO) cells compared to Ocy4
147 ese, serum miR-1260b level was significantly upregulated in patient serum discriminating from healthy
148 line databases we observed that HNF1alpha is upregulated in PDAC, which was also confirmed by our imm
149 an enzyme intrinsic to DHEA metabolism, was upregulated in PMD across experimental conditions (F((1,
150 multiple pathways have been described to be upregulated in PPR, a mechanistic understanding of the k
152 NAs) are enriched in the mammalian brain and upregulated in response to neuronal differentiation and
153 ramide with antimicrobial properties, is not upregulated in response to P. aeruginosa by cystic fibro
154 ss signaling pathway genes are conserved and upregulated in response to UV-B irradiation of the SAM.
157 undetectable in healthy adult epithelium but upregulated in select injured tissues, including fibroti
158 Moreover, we show that TRPV3 and PAR2 were upregulated in skin biopsies from patients and mice with
160 Ripening-related genes were significantly upregulated in SlLHP1b RNAi fruits and downregulated in
161 midinase (DHP), a zinc metalloenzyme that is upregulated in solid tumors but not in the corresponding
169 ted while the renin-angiotensin system (RAS) upregulated in the kidney of KS-tg/OVE mice compared to
171 t by methyljasmonate (MeJA) and by compounds upregulated in the metabolome of MeJA-treated Arabidopsi
172 in the wild-type mice and were significantly upregulated in the mutant mice, indicating that pre-tran
173 club, mucus, and ciliated cells; 3) ACE2 is upregulated in the SAE by smoking, significantly in men;
174 CathB3), and the associated gene CathB3, was upregulated in the salivary glands and saliva of aphids
176 y RNA Transcript (SCIRT), which was markedly upregulated in tumorspheres but colocalized with and cou
177 authors reported that ligands for NKG2D are upregulated in vitiligo perilesional skin and especially
179 ith quizartinib, a selective FLT3 inhibitor, upregulates inflammatory genes in DTPs and thereby confe
180 CoV-2-infected lung tissues show a massively upregulated innate immune response with signatures of nu
182 tially expressed genes (26 downregulated, 10 upregulated) involved in skeletal system development and
186 trocytes, which binds to gamma-secretase and upregulates its activity, thereby increasing the product
187 y, PERK phosphorylated eIF2alpha at Ser(51), upregulating its downstream effector proteins ATF4 and G
189 ) (s) gene expression, and energy starvation upregulated KFB(PAL) expression, which partially depends
191 , epithelial-to-mesenchymal transition (EMT) upregulates LARP6 expression to enhance protein synthesi
194 e C-beta and MAPKs MKK-3/6 and p38MAPK or to upregulate MEK-1/2 and ERK-1/2 in BALB/c-derived periton
196 In addition, we observed an enrichment of upregulated microglial genes, but this was not due to ne
197 his study, we show that TNF is sufficient to upregulate MINCLE, MCL, and DECTIN-2 in macrophages.
202 s the therapeutic efficacy of simultaneously upregulating miR-7 and downregulating miR-21 and establi
203 PI3K inactivation has a conserved effect of upregulating mitochondrial metabolism in both fly and ma
204 trix metalloproteinase (MMP)-12] is the most upregulated MMP in abdominal aortic aneurysm (AAA) and,
205 t-term incubation with IL-3 dose-dependently upregulated MRGPRX2 expression in both, stimulation for
206 ession of fusogenic genes is decreased, Pax7 upregulated, MuSCs are fivefold more numerous and mis-po
207 for 6 weeks enhanced running performance and upregulated muscular and adipose Pgc-1alpha transcript l
209 transforming growth factor beta), additively upregulated myofibroblast-specific ECM genes independent
210 ased the intracellular NADH/NAD(+) ratio and upregulated NF-kappaB activation after LPS treatment, wh
211 cancer, promotes metabolic reprogramming and upregulates NRF2, a master regulator of the antioxidant
213 upregulated on impaired cells but instead is upregulated on highly functional cells that have recentl
214 CD8(+) T cell functional exhaustion) is not upregulated on impaired cells but instead is upregulated
215 crosis factor receptor 2 (TNFR2) is strongly upregulated on renal tubular epithelial cells by acute c
216 ts of the interleukin-18 (IL-18) pathway are upregulated on tumour-infiltrating lymphocytes, suggesti
217 2 inhibition downregulates NRG1-ERBB3, while upregulating pAkt T308 through an adaptive response invo
218 ied integrin-linked kinase (ILK) as the most upregulated pathway in sEV-treated epithelial cells, and
219 n factors critical for chordoma survival and upregulated pathways dominated by ATF4-driven stress and
220 gnaling pathways were the most significantly upregulated pathways in PPR lesional tissue and aligned
222 with this, NK cells of malaria-naive adults upregulated PD-1 following P. falciparum stimulation in
224 gether with IL-12, IL-15, and IL-18 not only upregulate PDCD1 transcription, but also activate a prev
225 preformed fibrils impaired autophagy flux by upregulating PELI1, which in turn, resulted in degradati
228 autonomous PV GPe neuron firing ex vivo was upregulated, presumably through homeostatic mechanisms,
229 mt2d promotes lung tumorigenesis in mice and upregulates pro-tumorigenic programs, including glycolys
230 d promote the formation of ductular scars by upregulating pro-fibrogenic cytokines and positively reg
233 in tumor cells led to adaptive resistance by upregulating programmed death-ligand 1 (PD-L1) and resul
234 nd macrophage products (CCL13) among the top upregulated proteins in AD blister fluid proteomic analy
235 STAT1 mRNA and interferon signaling, and it upregulates putative pro-viral genes (e.g., DYNLL1 and H
236 s of infected mice and examined the roles of upregulated regulatory genes in bacterial virulence.
237 found that biliatresone and decreases in GSH upregulated RhoU/Wrch1, a Wnt signaling family member, w
238 ne initiates ripening of mature green fruit, upregulates RIN expression and other changes, including
240 xcitability recapitulates TDP43 pathology by upregulating shortened TDP43 (sTDP43) splice isoforms.
241 dominantly, but not entirely, PKA-dependent. Upregulated sites in PKA-null cells include Ser256 of AQ
242 equisite for cells overactivating FAK_SRC to upregulate SNAIL and acquire a mesenchymal phenotype and
244 involved in sulfate and Met metabolism were upregulated, suggesting regulation of the pool of free a
245 tory dendritic cells (migDC2) that similarly upregulate surface co-stimulatory molecules but express
247 strate that endogenous fumarate accumulation upregulates surface expression of the immune stimulatory
248 lymph nodes and gut, where, upon entry, they upregulate T-bet and coexpress IL-17, IL-22, and IFN-gam
249 ort that ECM through laminin-integrin alpha6 upregulates ten-eleven translocation enzyme 3 (TET3) dio
250 hus, RTK-mediated host invasion by chlamydia upregulated TGF-beta expression and signaling, which coo
253 tension homolog (PTEN) via the PDZ domain to upregulate the phosphorylation and SUMOylation of PTEN a
254 tegrated stress response, whereas MLIII mice upregulate the proteasome system in their glomeruli.
255 STAT3 relative to phospho-Ser727 and fail to upregulate the STAT3 target Socs3, which is required to
257 l fragmentation in neurons, and importantly, upregulated the expression of CX3CL1, a unique chemokine
258 ry gene expression, but IDL more effectively upregulated the expression of genes associated with kera
261 antigen receptor (TCR) stimulation, T cells upregulated the IL-23 receptor and the IL-23alpha p19 su
262 had a priming effect on gene expression and upregulated the pathways and genes associated with plant
263 me- and concentration-dependent manners, and upregulated the proliferation of astrocytes based on inc
265 of CpxA periplasmic histidine residues, and upregulates the fabA and fabB genes, leading to increase
266 n the ER, an early phenotype of the disease, upregulates the formation of these transient DRMs by ind
268 ites associated with increased lifespan, and upregulates the levels of tyrosine-derived neuromediator
269 that ligand activation of PPARalpha directly upregulates the long non-coding RNA gene Gm15441 through
272 tein expression and phosphorylation of AMPK, upregulating the expression of a key regulatory glycolyt
274 nd MAOB, and initiates the PD pathologies by upregulating these two pivotal players, in addition to e
275 n kidney organ culture, TNFR2 signaling both upregulates TNFR2 expression and promotes cell cycle ent
277 immune infiltrates, ELF3 in tumor cells was upregulated to trigger the activation of PI3K/Akt/NF-kap
279 action activated and stabilized NOTCH1 which upregulated transcription of NANOG essential for TIC exp
280 cant enriched biological process affected by upregulated transcripts, while those downregulated were
282 promoted the growth of cancer fragments and upregulated tumor-promoting genes, such as Runx2, MMP9,
283 fiber matrix deposition was accelerated with upregulated type I collagen and interleukin-1beta, and d
287 One of the secreted factors most strongly upregulated upon hypoxia was PCSK6 (proprotein convertas
288 study, we examined the set of genes that are upregulated upon inhibition of Wnt signaling in Wnt-addi
290 1-silencing transcription factor (CoREST) is upregulated upon reprogramming and required for the epig
292 d let-7c SBO has potential applicability for upregulating utrophin expression as a therapeutic approa
294 oxins such as MPTP and 6-hydroxydopamine can upregulate VGluT2 in surviving DA neurons, suggesting th
295 ly expressed genes (153 downregulated and 60 upregulated) were identified between Tmem106b-/- and wil
296 and that homeobox transcription factors are upregulated when this complex is exclusively present.
297 cell of tetraploid plants, DEMETER (DME) is upregulated, which can activate PRC2 family members FIS2
298 , IL17, IGFBP4, and MMP13 were significantly upregulated with aging in osteocyte-enriched samples.