ライフサイエンスコーパス: urate oxidase

1 biochemically that HpxO is an FAD-dependent urate oxidase.

2 tes were examined as potential inhibitors of urate oxidase.

3 hat there is no covalently bound cofactor in urate oxidase.

4 rate monoanion is the species which binds to urate oxidase.

5 rum UA levels to 0 by infusing a recombinant urate oxidase.

6 tration on the second virial coefficient for urate oxidase.

7 ess all three genes in this pathway, namely, urate oxidase, allantoinase, and allantoicase.

8 e and stand in contrast to the mechanisms of urate oxidase and (1H)-3-hydroxy-4-oxoquinaldine 2,4-dio

9 of hydroxyisourate hydrolase matched that of urate oxidase, and supports the hypothesis that hydroxyi

10 observed upon binding of 8-nitroxanthine to urate oxidase are consistent with increased anionic char

11 Rasburicase is a new recombinant form of urate oxidase available for clinical evaluation.

12 the enzyme active site, and Raman spectra of urate oxidase-bound 8-nitroxanthine suggest that both th

13 Urate oxidase catalyzes the enzymatic oxidation of uric

14 Urate oxidase catalyzes the oxidation of urate without t

15 beta-galactosidase reporter gene or to a rat urate oxidase cDNA and establishing stably transfected A

16 In species other than humans, uricase (urate oxidase) converts urate to allantoin, which is mor

17 ase kinase kinase in Magnaporthe oryzae, and urate oxidase (designated ClUrase) were functionally cha

18 AD), contrasting with all previously studied urate oxidase enzymes, which have no cofactor requiremen

19 Moreover, knockdown of urate oxidase expression by RNA interference demonstrate

20 lymphoma in the United States is the use of urate oxidase for prevention of tumor lysis syndrome and

21 The gene encoding urate oxidase from Bacillus subtilis has been cloned and

22 binding of the inhibitor 8-nitroxanthine to urate oxidase has been investigated by Raman and UV-visi

23 rate concentration (PUA), related to loss of urate oxidase in evolution, is postulated to protect hum

24 Moreover, when mice treated with the urate oxidase inhibitor potassium oxonate were fed inosi

25 The calculated molecular mass of urate oxidase is 35,052 Da; therefore, these data sugges

26 sed that oxidation of the substrate urate by urate oxidase is facilitated by formation of the substra

27 The kinetic mechanism of urate oxidase isolated from soybean root nodules has bee

28 gene of allantoin biosynthesis pathway i.e., urate oxidase of the halophytic species Oryza coarctata

29 the allantoin-mediated salinity tolerance in urate oxidase overexpressed lines of Arabidopsis.

30 avenous (IV) PEGylated recombinant mammalian urate oxidase (PEG-uricase) for the treatment of severe

31 Recombinant urate oxidase (rasburicase) is a newer agent that direct

32 sis of 5-hydroxyisourate, the product of the urate oxidase reaction.

33 xyisourate, which is the true product of the urate oxidase reaction.

34 HpxO is a flavin-dependent urate oxidase that catalyzes the hydroxylation of uric a

35 We have isolated a urate oxidase (uox) mutant of Arabidopsis thaliana that

36 jugation assay, two sites (W160 and D112) of urate oxidase (Uox), a model therapeutic protein, were s

37 Urate oxidase (Uox), a therapeutic enzyme for treatment

38 Exemplified with urate oxidase (UOx), the enzyme used for hyperuricemia t

39 nsformation, a full-length cDNA encoding rat urate oxidase (UOX), which oxidizes uric acid to allanto

40 evolutionary disruption of the gene encoding urate oxidase (UOx).

41 The gene encoding urate oxidase was cloned from soybeans and expressed in

42 The oxidation of urate catalyzed by soybean urate oxidase was studied under single-turnover conditio

43 sis involving single and multiple mutants of urate oxidase, xanthine dehydrogenase, nucleoside hydrol