ライフサイエンスコーパス: ureteric bud

1 that later emerges as the tip of the primary ureteric bud.

2 ffect more mature structures or cells in the ureteric bud.

3 ric mesenchyme to inductive signals from the ureteric bud.

4 ing the inductive signals emanating from the ureteric bud.

5 d as simply the non-branching portion of the ureteric bud.

6 GDNF supplied only by the Wolffian duct and ureteric bud.

7 in turn elicits an inductive signal from the ureteric bud.

8 including the proximal tubular cells and the ureteric bud.

9 embryonic circulation form a ring around the ureteric bud.

10 y organ cultures stimulates branching of the ureteric bud.

11 reduction of the growth and branching of the ureteric bud.

12 istinct analages, metanephric mesenchyme and ureteric bud.

13 stromal cells control Ret expression in the ureteric bud.

14 esenchyme is independent of induction by the ureteric bud.

15 It is not found in the ureteric bud.

16 iple branching morphogenesis of the isolated ureteric bud.

17 bud growth and downregulation of Ret in the ureteric bud.

18 rentiate in response to WNT signals from the ureteric bud.

19 elopment from metanephric mesenchyme but not ureteric bud.

20 pression of a stabilized beta-catenin in the ureteric bud.

21 pends on precise control of branching of the ureteric bud.

22 one from mouse E12.5 and one from rat E13.5 ureteric buds.

23 pic mesonephric tubules and ectopic anterior ureteric buds.

24 Ret knockout mice do not form the ureteric bud, a caudal outgrowth of the Wolffian duct an

25 timized method for making a branch-competent ureteric bud, a tissue fundamental to kidney development

26 ed in its pathogenesis: A primary failure of ureteric bud activity and a disruption produced by fetal

27 MM leads to kidneys with cranially displaced ureteric buds along the Wolffian duct or duplex ureters.

28 ops from interactions between the epithelial ureteric bud and adjacent metanephric mesenchyme, which

29 Using a HoxB7cre transgene expressed in ureteric bud and collecting duct, we find that developme

30 ng kidney showed expression in the branching ureteric bud and collecting ducts, expression that persi

31 w that they are targeted by factors from the ureteric bud and from the renal stroma, and that epithel

32 e after receiving inductive signals from the ureteric bud and from the renal stroma.

33 ation of Dchs1 also reduces branching of the ureteric bud and impairs differentiation of ureteric bud

34 Thereafter, Klf6 was expressed in the ureteric bud and its branches and in the collecting duct

35 Nestin was not detected in ureteric bud and its derivatives throughout renal develo

36 thelial diversification is stimulated by the ureteric bud and limited by renal stroma.

37 but it mediates its effects on the adjacent ureteric bud and metanephric mesenchyme, which fail to g

38 equired for normal morphogenesis of both the ureteric bud and metanephric mesenchyme-derived structur

39 DSTYK colocalizes with FGF receptors in the ureteric bud and metanephric mesenchyme.

40 derived through the mutual induction of the ureteric bud and metanephric mesoderm, whereas the malpi

41 or regulating branching morphogenesis of the ureteric bud and perhaps other embryonic epithelial stru

42 esult of reciprocal interactions between the ureteric bud and the blastema.

43 The localization of HGFA to the ureteric bud and the mesenchyme immediately adjacent to

44 inductive interactions between the embryonic ureteric bud and the metanephric mesenchyme are the basi

45 genesis depend on an interaction between the ureteric bud and the metanephric mesenchyme.

46 nesis depends on the interaction between the ureteric bud and the metanephric mesenchyme.

47 of which function in the interaction of the ureteric bud and the metanephric mesenchyme.

48 s, sidekick expression was observed first in ureteric bud and ureteric bud-derived tissues in a patte

49 essential for branching morphogenesis of the ureteric bud and, thus, metanephric development.

50 e are expressed at stage E12.5 in the murine ureteric bud and/or metanephric mesenchyme.

51 pment in Fat4(-/-) kidneys revealed abnormal ureteric budding and excessive RET signaling.

52 demonstrated that ErbB4 is expressed in the ureteric buds and developing tubules of embryonic rat ki

53 Inductive interactions between the branching ureteric buds and the metanephric mesenchyme lead to mes

54 tanephros for both proper development of the ureteric buds and the patterning of renal vesicles for n

55 Fgfr1/2(Mes-/-) mice develop a ureteric bud (and occasionally an ectopic bud) that does

56 Here, we report that nephric duct, ureteric bud, and collecting duct epithelia express high

57 itors (NP), early epithelial NP derivatives, ureteric bud, and cortical stroma; p-Creb was present in

58 al for normal branching morphogenesis of the ureteric bud, and lies downstream of significant extrace

59 express GFP in the mesonephros, metanephros, ureteric bud, and sex ducts may be useful for cell linea

60 nd that Erk MAP kinase is normally active in ureteric bud, and that inhibiting Erk activation with th

61 e the target of inductive signaling from the ureteric bud, and that renal stroma is not absolutely re

62 mesenchyme, and adjacent to the stalk of the ureteric bud, and that Vegfa was able to stimulate growt

63 etween the Wolffian duct, its derivative the ureteric bud, and their adjacent mesenchymes.

64 es branching of cultured wildtype and mutant ureteric buds, and achieves similar branching patterns w

65 The ureteric buds are either unbranched or have an atypical

66 niche, and Fgf9, secreted from the adjacent ureteric bud, are necessary and sufficient to maintain p

67 mes demonstrate the dichotomous branching of ureteric bud as it progresses from a simple, symmetrical

68 nvasion of the metanephric mesenchyme by the ureteric bud at an early stage of kidney development.

69 0.5 and in the induced mesenchyme around the ureteric bud at E11.5.

70 nt in mutant mesenchyme dorsal to the mutant ureteric bud at embryonic day (E) 10.5, while mutant ure

71 Specifically, as the ureteric bud bifurcates, endothelia form across the bifu

72 t reductions were measured in the numbers of ureteric bud branch points and tips, as well as in the t

73 rtex of ex fetu kidney rudiments, engineered ureteric buds branched and induced nephron formation; wh

74 Engineered ureteric buds branched in three-dimensional culture and

75 becomes progressively more elaborate as the ureteric bud branches into undifferentiated mesenchyme.

76 At the same time, the tips of the ureteric bud branches lost the typical appearance of an

77 In the RUB1 cells and ureteric bud branches of embryonic kidney, colocalizatio

78 ddition, DPP and annexin 2 colocalize in the ureteric bud branches of embryonic metanephric kidney.

79 vity with serine protease inhibitors reduced ureteric bud branching and inhibited glomerulogenesis an

80 The kidney develops by cycles of ureteric bud branching and nephron formation.

81 This is associated with reductions in ureteric bud branching and nephron number.

82 ved neurotrophic factor, a crucial factor in ureteric bud branching and subsequent nephron developmen

83 13.5 to 15.5 mice grow in size and continue ureteric bud branching and tubule formation over a 4- to

84 We observed slightly reduced ureteric bud branching but normal mesenchymal condensati

85 n, FGFR2, but not FGFR1, appears crucial for ureteric bud branching morphogenesis and stromal mesench

86 Ret receptor tyrosine kinase is crucial for ureteric bud branching morphogenesis during kidney devel

87 c mesenchyme cell line that induces isolated ureteric bud branching morphogenesis in the presence of

88 of embryonic kidneys with HDACi impairs the ureteric bud branching morphogenesis program and provoke

89 1, and interleukin-11 significantly enhanced ureteric bud branching morphogenesis.

90 lure in this mouse model and find defects in ureteric bud branching morphogenesis.

91 re) resulted in no apparent abnormalities in ureteric bud branching or in distal ureter maturation, a

92 ized by urinary tract abnormalities, reduced ureteric bud branching, and delayed disconnection of the

93 In the kidney, GATA3 is essential for ureteric bud branching, and mice without it fail to deve

94 Sema3a acts as a negative regulator of ureteric bud branching, but its function in glomerular d

95 ntrast, fgfr2(UB-/-) mice have very aberrant ureteric bud branching, thin ureteric bud stalks, and fe

96 t that is important for glomerulogenesis and ureteric bud branching.

97 e bcl-2 BH4 domain resulted in inhibition of ureteric bud branching.

98 ed to study individual cell behaviors during ureteric bud branching.

99 e renal hypoplasia, associated with impaired ureteric bud branching.

100 ependent on at least two known regulators of ureteric bud branching; the GDNF-Ret signalling system a

101 of the Wt1 gene eliminates outgrowth of the ureteric bud, but Gdnf has been identified as a target o

102 nsistently, TfR1 provided transferrin to the ureteric bud, but not to the capsule or the stroma.

103 While SCF is restricted to the ureteric bud, c-kit-positive cells are located within th

104 e, transgenic overexpression of Wnt9b in the ureteric bud causes reduced branching in multiple founde

105 several genetic labeling methods to observe ureteric bud cell behaviors in developing mouse kidneys.

106 PP binds to annexin 2 and 6 present in a rat ureteric bud cell line (RUB1).

107 tion of branching tubules in an immortalized ureteric bud cell line cultured three-dimensionally in a

108 of a dominant-negative RA receptor in mouse ureteric bud cells abolishes Ret expression and Ret-depe

109 rsely, we find that RA-receptor signaling in ureteric bud cells depends mainly on RA generated in nea

110 se around populations of cap mesenchymal and ureteric bud cells in a cyclical, predictable manner.

111 is, indicating that RA-receptor signaling in ureteric bud cells is crucial for renal development.

112 RA signaling between stromal mesenchyme and ureteric bud cells that regulates Ret expression both du

113 ryonic stem cells can be differentiated into ureteric bud cells.

114 nesis and Vangl2 is known to be expressed in ureteric bud/collecting duct and metanephric mesenchymal

115 ecting ducts: galectin-3 is expressed in the ureteric bud/collecting duct lineage during nephrogenesi

116 s of the Wolffian ducts and the duct derived ureteric bud/collecting duct system in an undifferentiat

117 ferent transcripts that were enriched in the ureteric bud compared with metanephric mesenchyme and pr

118 In genetically mosaic mouse ureteric buds, competition between phenotypically mutant

119 tified several genes whose expression in the ureteric bud depends on Etv4 and Etv5, including Cxcr4,

120 Branching of ureteric bud-derived epithelial tubes is a key morphogen

121 These data suggest that ureteric bud-derived SCF elicits growth-promoting effect

122 ssion was observed first in ureteric bud and ureteric bud-derived tissues in a pattern similar to oth

123 trast, mice lacking talins in the developing ureteric bud developed kidney agenesis and collecting du

124 s expressed Cre recombinase in the branching ureteric bud, developing renal tubules, and sex ducts.

125 ively in renal tubules, mesonephric tubules, ureteric bud, developing ureter, and Wolffian duct.

126 nsidered critical for correct positioning of ureteric bud development.

127 m of significant extracellular regulators of ureteric bud development.

128 ype II receptor in mice at the initiation of ureteric bud development.

129 We characterized isolated engineered ureteric buds differentiated from embryonic stem cells i

130 Troy is expressed in the ureteric bud during embryonic development.

131 It begins when a single ureteric bud emerges from the nephric duct in response t

132 s highly expressed in the basal membranes of ureteric bud epithelia during early development of the m

133 F and controls outgrowth and invasion of the ureteric bud epithelia in the developing kidney.

134 renal medulla are derived from Pax2-positive ureteric bud epithelia that continue to express Pax2 and

135 n a punctate pattern at the basal surface of ureteric bud epithelia.

136 in associated with the Wolffian duct and the ureteric bud, epithelial structures with well-defined ro

137 a new reciprocal signaling loop between the ureteric bud epithelium and the stromal mesenchyme, depe

138 cate a novel role of Wnt7b signaling and the ureteric bud epithelium in renal medullary capillary dev

139 Signaling by the ureteric bud epithelium is essential for survival, proli

140 elopmentally regulated and restricted to the ureteric bud epithelium of the fetal metanephric kidney.

141 utively active, cAMP-independent PRKX in the ureteric bud epithelium stimulates branching morphogenes

142 nt involves reciprocal signaling between the ureteric bud epithelium, inducing metanephric mesenchyme

143 Nephronectin mRNA is expressed in the ureteric bud epithelium, whereas alpha8beta1 is expresse

144 acts via receptors on the Wolffian duct and ureteric bud epithelium.

145 ud growth and branching morphogenesis of the ureteric bud epithelium.

146 ix1, but not Six2, Sall1, or Pax2, while the ureteric bud expresses Ret and Pax2 normally.

147 e isolated progenitors were treated with the ureteric bud factor LIF, they expressed epithelial prote

148 Absence of fgfr1 from the ureteric bud (fgfr1(UB-/-)) results in no apparent renal

149 g fibroblast growth factor receptor 2 in the ureteric bud (Fgfr2(UB-/-)) and in littermate controls.

150 aken from Gdf11 null embryos induced ectopic ureteric bud formation along the Wolffian duct.

151 ession and Ret-dependent functions including ureteric bud formation and branching morphogenesis, indi

152 early metanephric mesenchyme, which induces ureteric bud formation and branching.

153 nchyme and are required for the induction of ureteric bud formation and its subsequent branching morp

154 derived neurotrophic factor (GDNF) initiates ureteric bud formation and promotes subsequent branching

155 ls that regulates Ret expression both during ureteric bud formation and within the developing collect

156 Histological analysis revealed a failure in ureteric bud formation at the initial stage of metanephr

157 ng the metanephric blastema and inducing the ureteric bud formation but not for its normal branching.

158 Although ureteric bud formation is normal in Vangl2(Lp/Lp) embryo

159 In the absence of Gdnf, ureteric bud formation is not initiated.

160 n the Wolffian duct epithelium contribute to ureteric bud formation.

161 Branching morphogenesis of the epithelial ureteric bud forms the renal collecting duct system and

162 The outgrowth of the ureteric bud from the posterior nephric duct epithelium

163 nt in directing the initial outgrowth of the ureteric bud from the Wolffian duct by controlling the e

164 In mouse Sall1 mutants, the ureteric bud grows out and invades the metanephric mesen

165 tors frizzled (Fz) 4 and Fz8 lead to reduced ureteric bud growth and a reduction in kidney size, a ph

166 rm a signaling complex that is essential for ureteric bud growth and branching morphogenesis of the u

167 Ureteric bud growth and branching requires GDNF signalin

168 to altered stromal cell patterning, impaired ureteric bud growth and downregulation of Ret in the ure

169 tically rescues renal development, restoring ureteric bud growth and stromal cell patterning.

170 rucial for controlling Ret expression in the ureteric bud; however, the mechanism by which retinoid-s

171 are excluded from the tips of the branching ureteric bud in chimeric kidneys.

172 ructures except those that were derived from ureteric bud in embryonic kidney through adult kidney.

173 e to the basement membrane of the developing ureteric bud in the embryonic kidney.

174 ng cells can functionally substitute for the ureteric bud in these interactions.

175 To look for ureteric bud induction defects in young embryos, we asse

176 ng axis in MM development and regulating the ureteric bud induction site are incompletely understood.

177 nce of alpha8beta1 integrin, invasion by the ureteric bud into the metanephric mesenchyme is inhibite

178 In the developing kidney, the epithelial ureteric bud invades the metanephric mesenchyme, which d

179 Loss of Six1 leads to a failure of ureteric bud invasion into the mesenchyme and subsequent

180 in the metanephric mesenchyme at the time of ureteric bud invasion.

181 The ureteric bud is an epithelial tube that undergoes branch

182 g the growth and branching of the epithelial ureteric bud is GDNF.

183 g morphogenesis of the Wolffian duct derived ureteric bud is integral in the generation of ureteric t

184 ix molecule FRAS1, normally expressed by the ureteric bud, leads to bilateral renal agenesis in human

185 e effect and showed significant increases in ureteric bud length and area.

186 nch points and tips, as well as in the total ureteric bud length, volume and area, while significant

187 delivery system and microinjection into the ureteric bud lumen of embryonic day 11 mouse metanephric

188 t of a developmental regulatory system and a ureteric bud marker.

189 region are expressed in developing nephrons, ureteric bud, mesonephric tubules, Wolffian duct, and Mu

190 Consistent with an important role in ureteric bud morphogenesis during kidney development, pl

191 lopment of a normal kidney depends on proper ureteric bud morphogenesis, the cellular events underlyi

192 are together important for Wolffian duct and ureteric bud morphogenesis.

193 ian examples of branching morphogenesis, the ureteric bud of the metanephric kidney.

194 d parasympathetic ganglia, as well as in the ureteric buds of the developing kidneys.

195 ed in mesenchymal derivatives but not in the ureteric buds of wild-type mice.

196 entiated MM (unlike the upper portion of the ureteric bud) or more differentiated metanephric kidney.

197 Pax2 mutants are deficient in ureteric bud outgrowth and do not express GDNF in the un

198 Lim 1 influences nephric duct extension and ureteric bud outgrowth by regulating and or maintaining

199 organ culture is not sufficient to stimulate ureteric bud outgrowth from Pax2 mutant nephric ducts, i

200 evelopment of metanephric kidney begins with ureteric bud outgrowth from the Wolffian duct (WD).

201 receptor on the Wolffian duct that regulates ureteric bud outgrowth in the development of a functiona

202 Altered ureteric bud outgrowth was identified in Lzts2 null embr

203 rophic factor (Gdnf), a gene known to direct ureteric bud outgrowth.

204 metanephric development predominantly to the ureteric bud, precursor of the collecting duct, and indu

205 mesoderm, nephric duct, mesonephric tubules, ureteric bud, pretubular aggregates and their derivative

206 efects but had cranially displaced or duplex ureteric buds, probably as a result of decreased Bmp4 ex

207 reteric bud was smaller and branching of the ureteric bud reduced.

208 sexpression of GDNF in the Wolffian duct and ureteric buds resulted in formation of multiple, ectopic

209 Spry1(-/-) embryos have supernumerary ureteric buds, resulting in the development of multiple

210 into Fras1(bl/bl) mice, thereby reducing the ureteric bud's expression of this anti-branching molecul

211 ation, regions of mutant mesenchyme near the ureteric bud(s) express Eya1 and Six1, but not Six2, Sal

212 While the ureteric bud(s) initiates, it does not elongate or branc

213 In the second part of the loop, ureteric bud signals dependent on Ret control stromal ce

214 distribution in the caudal Wolffian duct and ureteric bud, similar to Ret(-/-) cells, revealing a cel

215 e very aberrant ureteric bud branching, thin ureteric bud stalks, and fewer ureteric bud tips.

216 es Gdnf, which stimulates branching, and the ureteric bud stimulates continued growth of the mesenchy

217 oordinates the position and outgrowth of the ureteric bud such that kidney development can begin.

218 ds to a virtual absence of MM and unbranched ureteric buds that are occasionally duplex.

219 ic kidneys that were caused by supernumerary ureteric buds that fail to separate from the wolffian du

220 ce and cell migration, develop supernumerary ureteric buds that remain inappropriately connected to t

221 Mice lacking this tyrosine grow ectopic ureteric buds that will ultimately form supernumerary ki

222 wever, once Gdnf stimulates branching of the ureteric bud, the Flk1-dependent angioblast signal is no

223 sential for outgrowth and positioning of the ureteric bud, the inducer of metanephric mesenchyme.

224 signals that control gene expression at the ureteric bud tip are not well understood.

225 ureteric bud and impairs differentiation of ureteric bud tip cells into trunk cells.

226 ce the movements and divisions of individual ureteric bud tip cells.

227 omprehensive gene expression analysis of the ureteric bud tip to identify bioactive molecules.

228 of the genes that was highly specific to the ureteric bud tip was cytokine-like factor 1 (CLF-1).

229 anephric mesenchyme are required to modulate ureteric bud tip Wnt patterning in order to initiate bra

230 he Wolffian duct that give rise to the first ureteric bud tip, initiating kidney development.

231 Fgfr2(UB-/-) ureteric bud tips also demonstrate inappropriate regions

232 , N-myc loss causes a decrease in numbers of ureteric bud tips and developing glomeruli in explants a

233 inductive interactions and feedback between ureteric bud tips and the surrounding mesenchyme.

234 When Erk activation is inhibited, ureteric bud tips show less cell proliferation than cont

235 al. identify a peculiar mitotic behavior in ureteric bud tips whereby dividing cells leave the epith

236 ls, which are abnormally arranged around the ureteric bud tips, and impairment of nephron morphogenes

237 ling promotes directed cell movements in the ureteric bud tips, and suggest a model in which these ce

238 nchyme does not aggregate tightly around the ureteric bud tips, but remains loosely associated, embed

239 xin2 are ectopically expressed in the mutant ureteric bud tips, suggesting that upregulated canonical

240 m the surrounding mesenchyme to cells at the ureteric bud tips, via the Ret receptor tyrosine kinase

241 me and nephron, but were underrepresented in ureteric bud tips.

242 terized by both increased number and size of ureteric bud tips.

243 anching, thin ureteric bud stalks, and fewer ureteric bud tips.

244 ggregation of SIX2-positive cells around the ureteric bud tips.

245 ion of Bmp4 in mesenchymal cells near mutant ureteric bud tips.

246 positively regulated by Ret signaling in the ureteric bud tips.

247 This engineered ureteric bud tissue also organized the mesenchyme into s

248 en fluorescent protein expression throughout ureteric bud tissue.

249 e embryonic stem cells to differentiate into ureteric bud tissue.

250 bud at embryonic day (E) 10.5, while mutant ureteric bud tissues undergo high rates of apoptosis by

251 action of the metanephric mesenchyme and the ureteric bud to be the major inductive event that mainta

252 ch represses Ret levels and signaling in the ureteric bud to ensure normal ureteric morphogenesis.

253 ns, and metanephric mesenchyme, inducing the ureteric bud to grow and branch.

254 he metanephric mesenchyme, which directs the ureteric bud to undergo repeated branching.

255 resumably enables the nephronectin-deficient ureteric buds to invade the metanephric mesenchyme and b

256 Branching morphogenesis of the ureteric bud (UB) [induced by the metanephric mesenchyme

257 Ectopic or supernumerary ureteric bud (UB) branches can result in urinary tract o

258 Ureteric bud (UB) branching during kidney development de

259 3 -/mice have been shown to display enhanced ureteric bud (UB) branching early in development, and cu

260 The specific roles of HSPGs and CSPGs on ureteric bud (UB) branching morphogenesis are unclear, a

261 n of both the Hdac1 and Hdac2 genes from the ureteric bud (UB) cell lineage of mice causes bilateral

262 at isolated metanephric mesenchymal (MM) and ureteric bud (UB) cells grown in three-dimensional (3D)

263 a very simple system consisting of isolated ureteric bud (UB) cells, which undergo branching morphog

264 nduction of metanephric mesenchymal (MM) and ureteric bud (UB) cells.

265 s study, we showed that Adam10 deficiency in ureteric bud (UB) derivatives leads to a decrease in uri

266 s of the kidney and urinary tract, including ureteric bud (UB) ectopia, double ureters/collecting sys

267 Ureteric bud (UB) emergence from the Wolffian duct (WD),

268 Mdm2 mRNA and protein are expressed in the ureteric bud (UB) epithelium and metanephric mesenchyme

269 otein-rich fractions inhibitory for isolated ureteric bud (UB) growth were separated from a condition

270 ween the metanephric mesenchyme (MM) and the ureteric bud (UB) in the developing kidney leads to bran

271 eloping kidney, we analyzed branching of the ureteric bud (UB) in whole kidney culture as well as in

272 d epithelial differentiation of the isolated ureteric bud (UB) independent of glial cell line-derived

273 in renal and urinary tract mesenchyme led to ureteric bud (UB) induction defects and vesicoureteral r

274 rphogenesis requires the sub-division of the ureteric bud (UB) into the intra-renal collecting system

275 ct morphogenesis requires subdivision of the ureteric bud (UB) into the intra-renal collecting system

276 at the normal branching morphogenesis of the ureteric bud (UB) is critical for development of the met

277 in branching morphogenesis of the epithelial ureteric bud (UB) is unclear.

278 Removal of Nf2 or Lats1/2 from the ureteric bud (UB) lineage causes loss of branching morph

279 of human pluripotent stem cells (hPSCs) into ureteric bud (UB) progenitor-like cells.

280 interactions that direct arborization of the ureteric bud (UB) remain incompletely understood.

281 ate that Fras1 is expressed in the branching ureteric bud (UB), and that renal agenesis occurs in hom

282 ed cap mesenchyme surrounding the tip of the ureteric bud (UB), is downregulated after differentiatio

283 ephric mesenchyme (MM), which along with the ureteric bud (UB), is responsible for the mutually induc

284 ulture in which the MM is separated from the ureteric bud (UB), the natural inducer, can be used as a

285 cting system of the kidney, derived from the ureteric bud (UB), undergoes repetitive bifid branching

286 Defects in the growth and branching of the ureteric bud (UB), which gives rise to the collecting sy

287 cting system of the kidney develops from the ureteric bud (UB), which undergoes branching morphogenes

288 develops from branching morphogenesis of the ureteric bud (UB).

289 gene was inactivated in the developing mouse ureteric bud (UB).

290 The ureteric buds (UBs) in mutants emerge as doublets from t

291 As the ureteric bud undergoes branching and segmentation, the s

292 last growth factor receptor 2 (Fgfr2) in the ureteric bud using a Hoxb7cre line (Fgfr2(UB-/-)) develo

293 inus at embryonic day 10.5, formation of the ureteric bud was delayed, the ureteric bud was smaller a

294 phric mesenchyme of mutant embryos lacking a ureteric bud was found to be defective in the expression

295 rmation of the ureteric bud was delayed, the ureteric bud was smaller and branching of the ureteric b

296 To determine roles of FGFR1 and FGFR2 in the ureteric bud, we used a conditional targeting approach.

297 d cell behavior in the branching tips of the ureteric bud, which we term "mitosis-associated cell dis

298 he newly formed epithelial bud, known as the ureteric bud, will continue to branch ultimately differe

299 tractive factor to pattern the growth of the ureteric bud within the developing kidney, and that any

300 genously express Ksp-cadherin, including the ureteric bud, Wolffian duct, Mullerian duct, and develop