ライフサイエンスコーパス: uridine

1 d together with uridine or when given before uridine.

2 lated plant material, including nicotine and uridine.

3 glycosidic bond is C-C rather than C-N as in uridine.

4 nucleosides such as guanosine, cytidine and uridine.

5 f deoxyadenosine, deoxyinosine, cytidine and uridine.

6 ay through supplementation with an excess of uridine.

7 nal RNA editing via addition and deletion of uridines.

8 nce, a GAUC repeat framed by single-stranded uridines.

9 this end, i.e., C5-functionalization of LNA uridines.

10 here it directly marks RNAs with 3' terminal uridines.

11 expressed uptake of alpha-methylglucoside or uridine 1 hour later, we identified a RS1 domain (RS1-Re

12 nsor (viz., 2'-O-[(4-CF3-triazol-1-yl)methyl]uridine, 1) for (19)F NMR spectroscopic monitoring of RN

13 D box snoRNA and directs 2'-O-methylation at uridine 116 of 18S ribosomal RNA (rRNA).

14 PIWI protein Aubergine typically begin with uridine (1U), while piRNAs bound to Argonaute3, which ar

15 of dFdC: the natural pyrimidine nucleosides uridine, 2'-deoxyuridine and thymidine inhibited mycopla

16 ffective conversion (~6.5-10%) of uridine to uridine-2',3'-cyclophosphate in less than 1 h.

17 vine pancreatic ribonuclease A (RNaseA), and uridine-3'-phosphate (3'UMP).

18 Uridine 34 (U34) at the wobble position of the tRNA anti

19 tions of transfer RNAs (tRNAs) at the wobble uridine 34 (U34) base are highly conserved and contribut

20 on and diminished 2'-O-methylribosylation at uridine 34 in mutant tRNA[Ser]Sec.

21 nability to distinguish the diastereomers of uridine 5'-beta,gamma-fluoromethylenetriphosphate (beta,

22 mutant p53 target gene, which functions as a uridine 5'-diphosphatase (UDPase) in the endoplasmic ret

23 og was readily transformed in cells into the uridine 5'-diphosphate (UDP)-activated form, it was not

24 P2Y2 (UTP/ATP) and P2Y6 [ADP/UTP/uridine 5'-diphosphate (UDP)] have been shown to have pr

25 ch species, the galactan is constructed from uridine 5'-diphosphate-alpha-d-galactofuranose (UDP-Galf

26 c12g096870 genes, which encode seed-specific uridine 5'-diphosphate-glycosyltransferases.

27 Uridine 5'-diphosphate-N-acetylglucosamine (UDP-GlcNAc)

28 ynthesized as the activated sugar nucleotide uridine 5'-diphospho-beta-l-rhamnose (UDP-beta-l-Rha) or

29 (CYP) isoform 7A1 (CYP7A1), CYP27A1, CYP8B1, uridine 5'-diphospho-glucuronosyltransferase 1A1, 1A3, 1

30 ture, free and bound to the substrate analog uridine 5'-monophosphate.

31 Adenosine and uridine 5'-tetra- and 5'-pentaphosphates were synthesize

32 (ADO) and nucleotides such as ATP, ADP, and uridine 5'-triphosphate (UTP), among others, may serve a

33 as confirmed with fluorescein isothiocyanate-uridine 5'-triphosphate labeling, RNA fluorescence in si

34 Conversely, L-glutamine, agmatine, and uridine 5-monophosphate are produced in relatively large

35 to enable the incorporation of 5-azidomethyl uridine (5-AmU) into cellular RNA and promotes RNA label

36 modified, nontoxic uridine analog 5-ethynyl uridine (5-EU) in Arabidopsis (Arabidopsis thaliana) see

37 e, Pac13, which catalyses the dehydration of uridine-5'-aldehyde.

38 5 but not pan-Akt inhibitor MK2206 increased uridine-5'-diphosphate-hexose cell content which was sup

39 sively metabolized by hepatic and intestinal uridine-5'-diphospho-glucuronosyltransferases (UGTs), th

40 d with OATP1B3-1B7, is highly metabolized by uridine-5'-diphospho-glucuronosyltransferases (UGTs), wh

41 s a Gq protein-coupled receptor activated by uridine-5'-triphosphate (UTP), which is widely expressed

42 estigated the role of hydrocortisone (HC) on uridine-5'-triphosphate (UTP)-stimulated ion transport i

43 tended N(4)-(3-arylpropyl)oxy derivatives of uridine-5'-triphosphate were synthesized and potently st

44 ymes, we examined the engineerability of the uridine-54 tRNA methyltransferase, TrmA.

45 We have studied how uridine 56 and 93 pseudouridylation impacts conformation

46 Uridines 56 and 93 are both modified to pseudouridines (

47 eplacement of T by 2'-deoxy-5-(hydroxymethyl)uridine (5hmU) in the genomic DNA of Escherichia coli.

48 Uridine, a pyrimidine nucleoside present at high levels

49 cell surface hENT1 expression, and decrease uridine accumulation when presented together with uridin

50 ocations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular sites,

51 plicing, and RNA editing by substitution and uridine additions both reconstituting crucial coding seq

52 human and murine colon muscles also release uridine adenosine tetraphosphate (Up4A) spontaneously an

53 our nucleoside substitutes, namely cytidine, uridine, adenosine, and guanosine, were identified.

54 d, most notably, four nucleosides: cytidine, uridine, adenosine, and thymidine.

55 inase inhibition (with A134974), inosine, or uridine also required ARs, as each was abolished in the

56 est through the isoform tailed with a single uridine, although changes in this flux did not correspon

57 hat RNA labeling with the modified, nontoxic uridine analog 5-ethynyl uridine (5-EU) in Arabidopsis (

58 Reagent [PPN](2)[1] reacts with unprotected uridine and adenosine in the presence of a base under an

59 DA) catalyzes the deamination of cytidine to uridine and ammonia in the catabolic route of C nucleoti

60 5, 100, and 250 muM MPA) and upregulation of uridine and cytidine nucleotides (p < 0.001 at 24 h; 5 m

61 3A/L442I) previously shown to be involved in uridine and dipyridamole binding, suggested that BCR-ABL

62 is makes proliferation dependent on external uridine and enables us to control cell growth by modulat

63 f metal ions by the nucleobases of conserved uridine and guanosine in helix P4 of the RNA subunit (P

64 nding conformationally locked sugar modified uridine and guanosine nucleosides was achieved via Vorbr

65 The uridine and guanosine nucleosides were found to be inact

66 abditis elegans MUT-2, that adds alternating uridine and guanosine nucleotides to form poly(UG) tails

67 d predominantly directed the misinsertion of uridine and guanosine, respectively.

68 ced by supplementation of culture media with uridine and N-acetylglucosamine (GlcNAc), precursors for

69 cally contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphat

70 c protein in vivo are covalently marked with uridines and subsequently identified from extracted RNA

71 cal pyrimidine ribonucleosides (cytidine and uridine), and we show that, once generated, the pyrimidi

72 tearin, xylonolactone, shikimic acid, pseudo uridine, and dodecanol (0.5 mo); N-acetyl-D-hexosamine a

73 -acetylalanine, andro-steroid monosulfate 2, uridine, and gamma-glutamyl-leucine, showed independent

74 tes like tryptophan, proline, phenylalanine, uridine, and guanosine was found.

75 were briefly labeled with 5-ethynyl-2'-deoxy-uridine, and nuclei were subjected to two-parameter flow

76 biosynthesis; ELP3, 5-methoxycarbonylmethyl uridine; and RSAD1 and viperin, both of unknown function

77 itical mediators of insulin sensitivity, and uridine as an important metabolite contributed by the ad

78 ently introduced C5-functionalization of LNA uridines as an alternative and synthetically more straig

79 iolation of the universally conserved methyl-uridine at position 54 stabilizes tRNAs from thermophili

80 Each BP lacked canonical uridines at position -2 relative to the BP adenines, wit

81 l modifications are introduced at the wobble uridines at position 34 in transfer RNAs (tRNAs), which

82 ombination (CSR) by deaminating cytidines to uridines at V region (V) genes and switch (S) regions.

83 e outlined and the syntheses of cytidine and uridine azo dye analogues derived from 6-aminouracil are

84 These proteins convert cytidine bases to uridine bases in retroviral DNA.

85 en the RNA, while backbone atoms specify the uridine bases.

86 diameter of the hexamer and passes over the uridine-binding proximal-face pore, whereas the remainin

87 in a mechanism involving adipocyte-dependent uridine biosynthesis and leptin signaling.

88 sitive regulator of a key enzyme involved in uridine biosynthesis; namely, uridine monophosphate synt

89 uoro-3'-C-hydroxymethyl-2',3'-endo-methylene-uridine by X-ray crystallography yielded the principal c

90 sperm organelles, cytidines are converted to uridines by a deamination reaction in the process termed

91 mRNAs are posttranscriptionally converted to uridines by RNA editing.

92 ing Frames (ORFs) resulting from Cytidine to Uridine (c->u) editing substitutions which occur in the

93 land plants are modified through cytidine to uridine (C-to-U) RNA editing.

94 Here, we report a cytidine-to-uridine (C-to-U) RNA editor, referred to as RNA Editing

95 The simple nonredox substitution of the C2-uridine carbonyl oxygen by sulfur is catalyzed by tRNA t

96 -containing cofactor FAD and highly abundant uridine-containing cell wall precursors, UDP-Glucose and

97 (UBER) enzymes target and cleave A3G-edited uridine-containing viral cDNA.

98 th metal ions, demonstrating that the bulged uridine coordinates at least one catalytic metal ion thr

99 munity depend primarily on the length of the uridine core within this motif.

100 pyrimidine ribonucleosides, which rely upon uridine-cytidine kinase 2 (UCK2) for activation, 2'-AzCy

101 eering to alter the substrate specificity of uridine-cytidine kinase 2 (UCK2), a key enzyme in the py

102 new small molecule-enzyme pair consisting of uridine/cytidine kinase 2 and 2'-azidouridine.

103 ine is only incorporated in cells expressing uridine/cytidine kinase 2 and characterize selectivity m

104 ntify two Arabidopsis (Arabidopsis thaliana) uridine/cytidine kinases, UCK1 and UCK2, which are locat

105 RIG-I protein, where RIG-I recognizes a poly-uridine/cytosine motif in the viral genome.

106 ay result in the activation of glycogenesis, uridine-dependent nucleotide synthesis, protein synthesi

107 -methylated d-ribose and l-lyxose-configured uridine derivatives by a base-mediated ring-opening of t

108 strategy for the synthesis of 5'-substituted-uridine derivatives is described.

109 dation, performed at a multigram scale, of a uridine-derived alkene.

110 A sensitive uridine-derived sensor (viz., 2'-O-[(4-CF3-triazol-1-yl)

111 zes the reversible conversion of sucrose and uridine diphosphate (UDP) into fructose and UDP-glucose,

112 Uridine diphosphate (UDP)-activated purinergic receptor

113 d by a series of glycosylations catalyzed by uridine diphosphate (UDP)-dependent glucosyltransferases

114 to biosynthesize the nucleotide-sugar donor uridine diphosphate (UDP)-GalNAzMe from a sugar-1-phosph

115 o GlcNAc-1-phosphate during the synthesis of uridine diphosphate (UDP)-GlcNAc, a sugar nucleotide cri

116 ic steps of this pathway involve a series of uridine diphosphate (UDP)-linked peptidoglycan intermedi

117 ltransferase MurU catalyzes the synthesis of uridine diphosphate (UDP)-MurNAc, a crucial precursor of

118 Unnatural uridine diphosphate (UDP)-sugar donors, UDP-4-deoxy-4-fl

119 sed on a wild-type galactosyltransferase and uridine diphosphate galactose (UDP-Gal) for global and s

120 46.82 mukat/Kg protein toward phloretin and uridine diphosphate glucose (UDPG) at an optimal tempera

121 tic data, revealed that H23 bound within the uridine diphosphate glucose binding pocket of yGsy2p.

122 Uridine diphosphate glucunosyltransferases (UGTs) metabo

123 lation, no heritable factors associated with uridine diphosphate glucuronyl transferase 2B7 metabolis

124 Despite the importance of uridine diphosphate glycosyltransferase (UGT) enzymes in

125 ome for sequences with similarity to terpene URIDINE DIPHOSPHATE GLYCOSYLTRANSFERASES (UGTs) from Ara

126 sis branch in M. truncatula In addition, two uridine diphosphate glycosyltransferases, UGT73F18 and U

127 iphosphate N-acetylhexosamine (UDP-HexNAc)]/[uridine diphosphate hexose (UDP-hexose)] ratio exhibited

128 e timecourses of (13)C isotopologue data for uridine diphosphate N-acetyl-D-glucosamine (UDP-GlcNAc)

129 uridine diphosphate N-acetylglucosamine and uridine diphosphate N-acetylgalactosamine, leading to th

130 osamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for

131 Glucose and glutamine are precursors of uridine diphosphate N-acetylglucosamine (UDP-GlcNAc), a

132 ructose 6-phosphate to eventually synthesize uridine diphosphate N-acetylglucosamine (UDP-GlcNAc).

133 nsferase pp-alpha-GanT2 able to utilize both uridine diphosphate N-acetylglucosamine and uridine diph

134 ich catalyzes a key step in the synthesis of uridine diphosphate N-acetylglucosamine, which is requir

135 fect on the biosynthetic reactions involving uridine diphosphate N-acetylglucosamine.

136 decreased, whereas the distribution of the [uridine diphosphate N-acetylhexosamine (UDP-HexNAc)]/[ur

137 Selected compounds tested at the two uridine diphosphate-activated P2Y receptor subtypes show

138 O-GlcNAcylation requires uridine diphosphate-GlcNAc, a precursor responsive to nu

139 We used rs6742078 located in the uridine diphosphate-glucuronosyltransferase locus as an

140 ted by decreased enzyme activity and reduced uridine diphosphate-N-acetyl-D-glucosamine, along with d

141 nce studies indicated thatlymphostatin binds uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) but

142 mine biosynthetic pathway (HBP), to increase uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc).

143 Candidate uridine-diphosphate glycosyltransferase genes (UGTs) wer

144 It is mediated by uridine-diphosphate glycosyltransferases (UGTs), that ac

145 We demonstrate that recombinant JGT utilizes uridine diphosphoglucose to transfer glucose to hmU in t

146 A predominant uridine downstream PSSs served as a processing signature

147 biting viral cDNA production and cytidine-to-uridine-driven hypermutation of this cDNA.

148 ing is converting hundreds of cytosines into uridines during organelle gene expression of land plants

149 by the earlier discovery of tRNA cytosine-to-uridine editing in eukaryotes, a reaction that has not b

150 Additionally, by employing 5-ethynyl uridine (EU) incorporation analysis, ablation of PADI1 f

151 Using 5-ethynyl uridine (EU) to metabolically label nascent RNA, we meas

152 entate ketal at the carbohydrate backbone of uridine, facilitates a switchable diastereoselective alp

153 A-deficient (rho0) recipient cells following uridine-free selection, although exogenous mtDNA is lost

154 ase I and II enzymes (cytochrome P450 (CYP), uridine glucuronic acid transferase (UGT), and sulfotran

155 Our results indicate that plasma uridine governs energy homeostasis and thermoregulation

156 R-133a, -146a, and -208a) were diminished by uridine-->adenosine mutation and by RNase pretreatment.

157 findings that implicate leptin signaling in uridine homeostasis and consequent metabolic control and

158 Further, feeding-induced clearance of plasma uridine improves glucose metabolism.

159 Replacing the uridine in CCUG repeats with pseudouridine (Psi) resulte

160 of cytidine but also CMP, cytosine, and some uridine in seeds.

161 ase-pair with a post-transcriptionally added uridine in the miR-27a tail.

162 dition of mcm(5) and ncm(5) modifications to uridine in the tRNA anticodon 'wobble' position in both

163 way responsible for the thiolation of wobble uridines in cytoplasmic tRNAs tK(UUU), tQ(UUG) and tE(UU

164 RNAs to direct the insertion and deletion of uridines in mitochondrial mRNAs.

165 The Elongator complex modifies uridines in the wobble position and is highly conserved

166 disease exhibit elevated lactate and reduced uridine; in McArdle disease purine nucleotide metabolite

167 rmia is inhibition of adenosine transport by uridine, increasing local extracellular adenosine levels

168 The proposed mechanism for uridine-induced hypothermia is inhibition of adenosine t

169 approaches allowed us to map the details of uridine insertion and deletion editing events upon the k

170 Uridine insertion and deletion RNA editing generates fun

171 Uridine insertion and deletion RNA editing generates fun

172 g regulation of mRNAs that require extensive uridine insertion/deletion (U-indel) editing for their m

173 st pre-mRNAs proceed through 3' adenylation, uridine insertion/deletion editing, and 3' A/U-tailing.

174 Here, we review the mechanism of uridine insertion/deletion mRNA editing in kinetoplastid

175 Uridine insertion/deletion RNA editing is an essential p

176 d protists and creates translatable mRNAs by uridine insertion/deletion.

177 tretches, which must be remodeled to promote uridine insertion/deletion.

178 Modeling of a 3' terminal Uridine into the catalytic pocket of Nbr EXO indicates t

179 Elevation of plasma uridine is required for the drop in body temperature tha

180 ted substrate stem-loop, in which the target uridine is substituted by 5-fluorouridine (5-FU), reveal

181 The third uridine is turned outwards or inward, wedging between th

182 We found that plasma uridine levels are regulated by fasting and refeeding in

183 In contrast, refeeding reduces plasma uridine levels through biliary clearance.

184 Fasting increases plasma uridine levels, and this increase relies largely on adip

185 rent subfamilies selectively reduce distinct uridines, located at spatially unique positions of folde

186 Methyl-5-uridine (m5U) is one the most abundant non-canonical bas

187 yne- or azide-modified analogs of thymidine, uridine, methionine, and glucosamine to label nascent sy

188 ion in Elp1 may be essential for tRNA wobble uridine modification by acting as tRNA binding motif.

189 on, ubiquitination and cytosolic tRNA wobble uridine modification via 5-methoxycarbonylmethyl-2-thiou

190 tial for Elongator's function in tRNA wobble uridine modification.

191 ranslation elongation factor eEF2 and wobble uridine modifications of tRNAs.

192 ipose tissue in comparison to unmodified and uridine-modified linear mRNAs.

193 though these natural products share a common uridine moiety, their core structures vary substantially

194 alpha-L-LNA uridine monomers that are conjugated to small C5-alkynyl

195 ted into aspartate (a nucleotide precursor), uridine monophosphate (a precursor of pyrimidine nucleos

196 AICAr increases orotate levels and decreases uridine monophosphate (UMP) levels, consistent with inhi

197 ated 5'-adenosine monophosphate (AMP) and 5'-uridine monophosphate (UMP) molecules confined in multi-

198 showcase our workflow by annotating N-methyl-uridine monophosphate (UMP), lysomonogalactosyl-monopalm

199 e that catalyzes the conversion of uracil to uridine monophosphate (UMP).

200 ng allosteric and substrate binding sites of uridine monophosphate kinase, and suggested that in solu

201 the genome, we determined that the conserved uridine monophosphate phosphoribosyltransferase (UMPS),

202 We find that uric acid directly inhibits uridine monophosphate synthase (UMPS) and consequently r

203 Using genome editing methods, we disrupt uridine monophosphate synthetase (UMPS) in the pyrimidin

204 oorotate dehydrogenase (quinone) (DHODH) and uridine monophosphate synthetase (UMPS), as well as lact

205 me involved in uridine biosynthesis; namely, uridine monophosphate synthetase (UMPS).

206 e), fluoride, or a nucleoside monophosphate (uridine monophosphate, deoxyadenosine monophosphate, and

207 Moreover, the presence of several umami (uridine monophosphate, inosine monophosphate, adenosine,

208 ngs to the class of 2'-deoxy-2'-spirooxetane uridine nucleotide prodrugs which are known as inhibitor

209 Our work reveals that replacing a single uridine nucleotide with Psi in an mRNA codon impedes ami

210 alyze deamination of cytidine nucleotides to uridine nucleotides (C-to-U) in single-strand DNA substr

211 eaves mitochondrial mRNA, inserts or deletes uridine nucleotides at specific positions and re-ligates

212 Conversely, uridine nucleotides bearing 5' oligophosphates saw progr

213 Surprisingly, two uridines of the signature sequence make triple interacti

214 ditional insights into the effects of 2-thio-uridine on RNA base pairing.

215 encoded cytidine or adenosine nucleotides to uridine or inosine, respectively, in mRNAs.

216 ne accumulation when presented together with uridine or when given before uridine.

217 e report, the discovery of beta-d-2'-Br,2'-F-uridine phosphoramidate diastereomers 27 and 28, as nont

218 report, the discovery of a beta-d-2'-Cl,2'-F-uridine phosphoramidate nucleotide 16, as a nontoxic pan

219 e 5'-monophosphate decarboxylase (OMPDC) and uridine phosphorylase (UP) genes.

220 Uridine phosphorylase (UP) is a key enzyme of pyrimidine

221 which in turn upregulated mRNA expression of uridine phosphorylase 1 (UPP1).

222 Thymidine phosphorylase and uridine phosphorylase double knockout mice recapitulated

223 Crystal structure of this uridine phosphorylase showed strict conservation of key

224 Four selected proteins, uridine phosphorylase-like protein-1, protein 21.1 (GL50

225 Moreover, uridine phosphorylases are not found in obligate oomycet

226 of other oomycete genomes revealed that both uridine phosphorylases are present in Phytophthora and P

227 y characterized two evolutionarily divergent uridine phosphorylases, PcUP1 and PcUP2 from the oomycet

228 Remarkably, the U2AF heterodimer binds weak, uridine-poor Py tracts as a mixture of closed and open U

229 Independent generation of the C2'-uridine radical (1) in RNA oligonucleotides via Norrish

230 ola virus shows that an addition of a single uridine residue in the glycoprotein gene at the editing

231 are predicted to direct the isomerization of uridine residues to pseudouridine in small nuclear RNA a

232 One example is the addition of non-templated uridine residues to the 3' end of transcripts.

233 gion [CRE(2C)] templates the addition of two uridine residues to the virus genome-encoded RNA replica

234 le-stranded RNA molecules between purine and uridine residues, which critically contributes to the su

235 preceding an 3' oligoU tail of at least four uridine residues.

236 GAPDH binds to numerous adenine-uridine rich elements (AREs) from various mRNA 3'-untran

237 ngiogenic transcripts containing adenine and uridine-rich elements were bound to ILF3 through RNA imm

238 R identified numerous copies of adenine- and uridine-rich elements, raising the possibility that unde

239 A 99-nucleotide, uridine-rich hairpin 5'pppRNA termed M8 stimulated an ex

240 A novel, sequence-dependent, uridine-rich RIG-I agonist generated a protective antivi

241 nces that encode an RNA hairpin and terminal uridine-rich segment; termination by the enzyme Rho, an

242 sands of mRNA precursors, mainly at intronic uridine-rich sequences and affects their splicing.

243 tes the assembly of RNA-protein complexes of uridine-rich small nuclear ribonucleoproteins (UsnRNPs).

244 processing of noncoding RNAs, including the uridine-rich small nuclear RNA (UsnRNA) and enhancer RNA

245 Uridine-rich small nuclear RNAs (snRNAs) are the basal c

246 n the U2AF heterodimer is bound to a strong, uridine-rich splice site, U2AF2 switches to a lower FRET

247 e, we report that SgrS forms a duplex with a uridine-rich translation-enhancing element in the manY 5

248 the main specificity factors of cytidine to uridine RNA editing.

249 n enrichment of Apobec1-mediated cytosine to uridine RNA editing.

250 2-Thio-uridine (s(2)U) is a modified nucleobase found in certai

251 de kinase is involved in cytidine as well as uridine salvage.

252 indicate a standard deviation of <10% in the uridine signal obtained for each area.

253 sequence on the 5' side of the terminator to uridines strengthened the binding of several ProQ-specif

254 Surprisingly, uridine supplementation increased NTD incidence, indepen

255 the folate-deficient diet, whereas maternal uridine supplementation increased NTD incidence, indepen

256 Uridine supplementation rescued these abnormalities, sug

257 us to control cell growth by modulating the uridine supply, both in vitro and in vivo after transpla

258 sed 5' cleavage RISC fragments with extended uridine tails.

259 m hydroxide ([TBA][OH]) yields adenosine and uridine tetraphosphates (p(4)A, p(4)U) in 92% and 85% yi

260 CDA converts 5hmdC and 5fdC into variants of uridine that are incorporated into DNA, resulting in acc

261 mediate the direct conversion of cytidine to uridine, thereby effecting a C-->T (or G-->A) substituti

262 rans Hoogsteen-Watson-Crick base pair with a uridine, thus becoming an integral part of the helical s

263 utwards or inward, wedging between the other uridines, thus filling the major groove.

264 folate-deficient diets and supplemented with uridine, thymidine, or deoxyuridine were bred, and litte

265 plementation with the pyrimidine nucleosides uridine, thymidine, or deoxyuridine with and without fol

266 (Escherichia coli); when fed food with a low uridine/thymidine (U/T) level, germline proliferation is

267 ic viral RNA by detecting crosslink-specific uridine to cytidine transitions in NGS data.

268 trate the effective conversion (~6.5-10%) of uridine to uridine-2',3'-cyclophosphate in less than 1 h

269 ctuation signals, and often adds hundreds of uridines to create protein-coding sequences.

270 The reduction of specific uridines to dihydrouridine is one of the most common mod

271 rough the specific insertion and deletion of uridines to generate functional open reading frames, man

272 of interest is fused to an enzyme that adds uridines to the end of RNA.

273 nding, we modeled the saturation of cellular uridine tracts by this protein.

274 lice sites is coupled with longer repressive uridine tracts.

275 ng, explaining the preference for contiguous uridine tracts.

276 ribution of the full-length hnRNP C on short uridine tracts.

277 We characterized uridine transport in these cell lines and generated Baye

278 e dehydrogenase (DHODH), and the blockage of uridine transport into cells.

279 erevisiae Nilotinib inhibited hENT1-mediated uridine transport most potently (IC50 value, 0.7 mum) fo

280 Glycosylation of uridine triacetate gives products resulting from O- and

281 ke and abacavir, nevirapine, ticagrelor, and uridine triacetate had different IC(50) values for ENT1

282 bstantial levels of 2'-deoxy-2'-spirooxetane uridine triphosphate (8), a potent inhibitor of the HCV

283 (UGP) alternatively makes UDP-galactose from uridine triphosphate and galactose-1-phosphate.

284 RRP = resorufin phosphate, DUT = Dyomics-647 uridine triphosphate).

285 Six 1',5'-anhydrohexitol uridine triphosphates were synthesized with aromatic sub

286 ting cleavage signature is the location of a uridine two nucleotides downstream in a single-stranded

287 long stretches of alternating non-templated uridine (U) and guanosine (G) ribonucleotides to the 3'

288 stricted by their preference to start with a Uridine (U) at the 5' most position (1U-bias), a bias th

289 ound that 21-nt phasiRNAs with a 5'-terminal uridine (U) demonstrated cis-cleavage at PHAS precursors

290 otein editosomes catalyze pre-mRNA cleavage, uridine (U) insertion or deletion, and ligation as speci

291 e structurally diverse C5-functionalized LNA uridine (U) phosphoramidites were synthesized and incorp

292 al RNA recognition motif (RRM) known to bind uridine (U)-rich sequences.

293 Plant RNA editosomes modify cytidines (C) to uridines (U) at specific sites in plastid and mitochondr

294 substituted the universally conserved bulged uridine (U51) in the P4 helix of circularly permuted Bac

295 Twenty-one compounds inhibited uridine uptake and abacavir, nevirapine, ticagrelor, and

296 TKIs inhibited [(3)H]uridine uptake in a competitive manner.

297 Quantification of [(3)H]uridine uptake in the presence of the ENT-specific inhib

298 protecting groups for secondary alcohol and uridine ureido nitrogen are applied for simultaneous dep

299 The five binding pockets of RRM recognize uridines with an unusual 5'-to-3' gradient of base selec

300 cancer genomes by converting cytidines into uridines within ssDNA during replication.