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1 n regard to the common urinary glycoprotein, uromodulin.
2 /80(+) and CD11c(+) kidney cells phagocytize uromodulin.
3 esponsible for the physiological cleavage of uromodulin.
4 by mutations in the UMOD gene, which encodes Uromodulin, a glycosylphosphatidylinositol-anchored prot
5 hin the kidneys under high concentrations of uromodulin, a kidney-specific protein and that PyV-haufe
6 is due to immune system activation by mutant uromodulin, a mouse strain with a homologous cysteine to
7                                              Uromodulin, a protein exclusively produced by the kidney
8 ividuals with mutations in the gene encoding uromodulin (ADTKD-UMOD), consistent with MUC1 haploinsuf
9 t baseline, hepsin-deficient mice accumulate uromodulin, along with hyperactivated NKCC2, resulting i
10                                              Uromodulin (also known as Tamm-Horsfall protein) is a ki
11  expand the physiological role of hepsin and uromodulin and highlight the importance of hepsin-mediat
12  correlation found between urinary levels of uromodulin and markers of UTIs in the general population
13                       KRT40 colocalized with uromodulin and modulating its expression in thick ascend
14 lar diseases share common mediators, such as uromodulin and pro-adrenomedullin.
15 ted aggregated uromodulin, resulting in anti-uromodulin antibodies and circulating uromodulin contain
16              Variants in UMOD, which encodes uromodulin, are associated with renal function, and urin
17    Common variants in the UMOD gene encoding uromodulin, associated with risk of hypertension and CKD
18                                              Uromodulin-associated kidney disease (UAKD) is caused by
19 ameliorating the progressive renal damage in uromodulin-associated kidney diseases.
20  damage that exposes the renal interstitium, uromodulin becomes an endogenous danger signal.
21          Our findings define a key aspect of uromodulin biology and identify the first in vivo substr
22 Here, we delineate the latest discoveries in uromodulin biology and its emerging roles in modulating
23              They also provide insights into uromodulin biology and the association of UMOD variants
24                       Phagocytosis of mutant uromodulin by cultured dendritic cells resulted in activ
25 ase UMOD expression and urinary excretion of uromodulin, causing salt-sensitive hypertension and rena
26 enle's loop cells with wild-type and mutated uromodulin cDNA were evaluated to test this hypothesis.
27                                 Higher serum uromodulin concentration associated with a favorable met
28 set, we tested the genotype association with uromodulin concentration in the Atherosclerosis Risk in
29                                 Adding serum uromodulin concentration to established cardiovascular r
30 dy, we investigated the association of serum uromodulin concentration with cardiovascular biomarkers
31 itro experiments of the next step, only high uromodulin concentrations (>=1.25 mg/mL) aggregated PyV,
32                                  Low urinary uromodulin concentrations have been associated with incr
33                    We observed lower urinary uromodulin concentrations per each copy of the C allele
34                         In summary, elevated uromodulin concentrations precede the onset of CKD and a
35                           Geometric means of uromodulin concentrations were 51% higher in case than i
36                                              Uromodulin concentrations were available in 3057 of 3316
37 n contrast, in voided urine samples (n = 59) uromodulin concentrations were below aggregation concent
38                             Baseline urinary uromodulin concentrations were related to case-control s
39    PyV-haufen form within kidneys under high uromodulin concentrations.
40 loop cells that were transfected with mutant uromodulin constructs.
41 n anti-uromodulin antibodies and circulating uromodulin containing immune complexes with glomerular d
42                                              Uromodulin contains three epidermal growth factor (EGF)-
43 factor, ammonium, alpha 1 microglobulin, and uromodulin correlated with the increment of TScr and tub
44                Familial hyperuricemia due to uromodulin deficiency precedes but does not cause kidney
45 nal release and subsequent polymerization of uromodulin depend on its cleavage mediated by the serine
46      Full release of IL-1beta in response to uromodulin depended on priming of pro-IL-1beta expressio
47 itro abnormalities and to be the only mutant Uromodulin detected in conditioned medium from transfect
48 ssociated with intracellular accumulation of uromodulin, endoplasmic reticulum-stress and signs of tu
49      However, the genetic factors regulating uromodulin excretion are unknown.
50 esearch studies have gradually revealed that uromodulin exists in multiple forms and has important ro
51 spheric vancomycin aggregates entangled with uromodulin explained the vancomycin-associated ARF.
52 ion among DDAH1 expression, NO activity, and uromodulin expression supported by data from both animal
53 f EVs for size and morphology independent of uromodulin filaments.
54  importance of hepsin-mediated processing of uromodulin for kidney tubule homeostasis and salt sensit
55                          As a consequence of uromodulin gene mutations, individuals develop precociou
56 e similar clinical disorders associated with uromodulin gene mutations.
57 the progressive renal damage associated with uromodulin gene mutations.
58                                   The mutant Uromodulins had significantly delayed maturation, retent
59 e, a GWAS signal mapped to the gene encoding uromodulin has been shown to affect blood pressure by in
60       Already described several decades ago, uromodulin has gained the spotlight in recent years, sin
61  allele, driving higher urinary excretion of uromodulin, has been kept at a high frequency because of
62 dexed to creatinine (uUCR) urinary levels of uromodulin in 29,315 individuals of European ancestry fr
63 s, and sensitive assays for the detection of uromodulin in blood have become available.
64 itation of monoclonal free light chains with uromodulin in the distal tubules, defining light chain c
65 dulin (UMOD) gene is associated with reduced uromodulin in the proximal tubule cilia.
66                           However, measuring uromodulin in urine has several preanalytic drawbacks, a
67                                         Most uromodulin in urine is polymerized into highly organized
68 UMOD, and PDILT associate with the levels of uromodulin in urine.
69 e zona pellucida sperm binding proteins, and uromodulin, In addition, there is a repeat of a motif ca
70                          Each study measured uromodulin indexed to creatinine and conducted linear re
71                                 In addition, uromodulin-induced secretion of mature IL-1beta depended
72      Taken together, these data suggest that uromodulin is a NLRP3 agonist handled by antigen-present
73                                              Uromodulin is a zona pellucida-type protein essentially
74                                        While uromodulin is an individual case, these same site-specif
75                 Moreover, the discovery that uromodulin is associated with a spectrum of kidney disea
76 y organized filaments, whereas non-polymeric uromodulin is detected both in urine and in the circulat
77                                              Uromodulin is expressed exclusively in the thick ascendi
78                              The mucoprotein uromodulin is the most abundant protein in mammalian uri
79                                              Uromodulin is the most abundant protein in the urine.
80   Tamm-Horsfall protein (THP), also known as uromodulin, is a kidney-specific protein produced by cel
81                          Here, we noted that uromodulin isolated from human urine aggregates to large
82  In the third investigative step, none of 11 uromodulin-/- knockout mice (0%) with histologic signs o
83 , had the strongest association with urinary uromodulin levels (P<0.001).
84                                      Whether uromodulin levels associate with UMOD variants or with t
85                      Moreover, variations in uromodulin levels in urine and/or blood reflect kidney f
86  associated with renal function, and urinary uromodulin levels may be a biomarker for kidney disease.
87 ers of a G allele of this variant had higher uromodulin levels than noncarriers did (geometric means
88      We conducted a meta-analysis of urinary uromodulin levels to identify associated common genetic
89 CKD and an intermediate reduction of urinary uromodulin levels, in line with an intermediate traffick
90 e UMOD promoter region may influence urinary uromodulin levels.
91 J1, SORL1, and CAB39 associated with urinary uromodulin levels.
92 d in the thick ascending limb associate with uromodulin levels.
93                                              Uromodulin mainly exerts its function as an extracellula
94                                   Aggregated uromodulin may induce dendritic cell tolerance following
95                                              Uromodulin may, therefore, be a useful marker for cardio
96                           Thus, FJHN-causing Uromodulin mutants are retained in the ER, with impaired
97 cking, thereby indicating mechanisms whereby Uromodulin mutants may cause the phenotype of FJHN.
98 ant tubulointerstitial kidney disease due to uromodulin mutations (ADTKD-UMOD), a leading hereditary
99                                        These uromodulin nanoparticles activated isolated human monocy
100 Activation of NLRP3 required phagocytosis of uromodulin particles into lysosomes, cathepsin leakage,
101                    Although the discovery of uromodulin predates modern medicine, its significance in
102 in thick ascending limb (TAL) cells affected uromodulin processing and excretion.
103 ach, including extensive characterisation of uromodulin processing in cellular models and in specific
104              The expression of KRT40 affects uromodulin processing in TAL cells.
105 ells to demonstrate that hepsin influence on uromodulin processing is an important modulator of salt
106                                    Defective uromodulin processing is associated with various kidney
107 In conditions of high salt intake, defective uromodulin processing predisposes hepsin-deficient mice
108 tigated the effects of keratin-40 (KRT40) on uromodulin processing.
109 we generated a transgenic mouse in which the uromodulin promoter controlled expression of human HO-1.
110 tions in the UMOD gene, resulting in altered uromodulin protein in the gout-associated disorders fami
111                    The clinical relevance of uromodulin reflects its multifunctional nature, playing
112  expression exacerbates renal injury through uromodulin-related mechanisms.
113 netic studies of urate transportation and of uromodulin-related nephropathy emphasize the pivotal imp
114   Kidney-specific DAMPs include crystals and uromodulin released by renal tubular damage.
115 chanisms regulating the urinary excretion of uromodulin remain essentially unknown.
116 al cells to secrete IL-1beta may explain why uromodulin remains immunologically inert inside the lumi
117 biological relevance of a proper cleavage of uromodulin remains unknown.
118 ed new questions and ushered in a new era in uromodulin research.
119 els of intracellular and secreted aggregated uromodulin, resulting in anti-uromodulin antibodies and
120 n the region of the UMOD gene, which encodes uromodulin (Tamm-Horsfall protein), associate with chron
121 r CKD is clear, because the encoded protein, uromodulin (Tamm-Horsfall protein), is exclusively produ
122 ut not the prevalent soluble urinary protein uromodulin (Tamm-Horsfall protein), potently inhibited g
123 dies suggest that pathologic accumulation of uromodulin/Tamm-Horsfall glycoprotein (THP) occurs in th
124                                              Uromodulin/Tamm-Horsfall protein is not immunostimulator
125    The kidney-specific gene UMOD encodes for uromodulin, the most abundant protein excreted in normal
126                                              Uromodulin, the most abundant protein excreted in normal
127 cation, provide insights into the biology of uromodulin, the role of keratins in the kidney, and the
128 ivo human urine models, NETs interacted with uromodulin to form large webs that entrapped the bacteri
129                   We evaluated urinary donor uromodulin (UMOD) and osteopontin (OPN) in recipient gra
130 ry with roles for proteolytic degradation of uromodulin (UMOD) and several collagens, including COL1A
131  impairment attributable to mutations of the uromodulin (UMOD) gene is associated with reduced uromod
132 disease (UAKD) is caused by mutations in the uromodulin (UMOD) gene that result in a misfolded form o
133                             The glycoprotein uromodulin (UMOD) is the most abundant protein in human
134                  We previously reported that Uromodulin (UMOD) protects against nephrolithiasis by up
135 cyte chemoattractant protein 1 (MCP-1/CCL2), uromodulin (UMOD), and YKL-40 (CHI3L1) were measured in
136 and reported three urinary biomarkers namely Uromodulin (UMOD), Osteopontin (OPN), and Interleukin-9
137                  The trafficking dynamics of uromodulin (UMOD), the most abundant protein in human ur
138                                              Uromodulin (UMOD)-associated kidney disease (UAKD) belon
139                                              Uromodulin (UMOD)/Tamm-Horsfall protein, the most abunda
140 atio of CKD per 1-SD higher concentration of uromodulin was 1.72 (95% confidence interval 1.07 to 2.7
141 isfolded proteins in the kidney (mucin 1 and uromodulin), we outline the general principles of protei
142                         Wild-type and mutant Uromodulins were functionally studied by expression in H
143  PyV-haufen shedding, compared with 10 of 14 uromodulin+/+ wild-type mice (71%).
144  investigative step showed colocalization of uromodulin with aggregated PyV (1) in 10 kidneys with Py
145            In conclusion, the interaction of uromodulin with nanospheric vancomycin aggregates repres
146                          The interactions of uromodulin with the immune system, which were initially

 
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