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1 scent formation, including the A6 protein of vaccinia virus.
2 merous RNA viruses but enhances the entry of vaccinia virus.
3 ized against foreign rhesus D alloantigen or vaccinia virus.
4 the movement of microbial pathogens such as vaccinia virus.
5 athway components for cell-to-cell spread of vaccinia virus.
6 mory CD8(+) T cells following infection with vaccinia virus.
7 sing data from humans, domestic pigeons, and vaccinia virus.
8 the crystal structure of the H7 protein from vaccinia virus.
9 g during a severe respiratory infection with vaccinia virus.
10 uitment of leukocytes, which is unique among vaccinia viruses.
13 at causes a persistent/latent infection, and vaccinia virus, a poxvirus that is cleared by the host.
16 e-prototype JX-594), a replication-competent vaccinia virus administered by intravenous injection, to
17 res of the antitumor properties of oncolytic vaccinia viruses, all of which can be amplified by the m
18 steria monocytogenes, Shigella flexneri, and Vaccinia virus among other pathogens use the same common
19 es of fatty acid in the diet on infection by vaccinia virus, an acute infection that begins in the re
21 oping potent neutralizing antibodies against vaccinia virus and comprehensively characterizing their
27 bisbenzimide derivatives are potent against vaccinia virus and other poxviruses but ineffective agai
30 bility to monkeypox virus, cowpox virus, and vaccinia virus and thus providing a unique model for stu
31 r of the Orthopoxvirus genus, which includes Vaccinia virus and Variola virus (the causative agent of
34 uses including Herpes Simplex Virus-1 and-2, Vaccinia virus, and Zika virus through a type I interfer
35 by extensively passaging the chorioallantois vaccinia virus Ankara (CVA) vaccine strain in chicken em
36 uential immunizations with DNA (D), modified vaccinia virus Ankara (MVA) (M), and protein immunogens,
37 The clinically relevant vectors modified vaccinia virus Ankara (MVA) and the chimpanzee adenoviru
38 impanzee adenovirus 63 (ChAd63) and modified vaccinia virus Ankara (MVA) and used to immunize mice in
41 nuclear antigen EBNA1 followed by a modified vaccinia virus Ankara (MVA) booster, induced significant
42 priming with DNA and boosting with modified vaccinia virus Ankara (MVA) expressing HIV-1 Env on viru
44 asal administration of the poxvirus modified vaccinia virus Ankara (MVA) is sufficient to induce high
45 ctors simian adenovirus 63 (ChAd63)-modified vaccinia virus Ankara (MVA) is the most potent inducer o
46 we show that a CD40L-adjuvanted DNA/modified vaccinia virus Ankara (MVA) simian immunodeficiency viru
47 M1L is absent in the attenuated modified vaccinia virus Ankara (MVA) strain of VACV, a strain tha
48 We have constructed a recombinant modified vaccinia virus Ankara (MVA) that expresses an H5N1 mosai
49 DCs or expressed from a recombinant modified vaccinia virus Ankara (MVA) vector, improved priming of
51 ity to both insert Ag85A and vector modified vaccinia virus Ankara (MVA) was assessed by ex-vivo inte
55 with different combinations of DNA, modified vaccinia virus Ankara (MVA), soluble gp140 protein, and
56 ific T cells induced by a DNA-prime modified vaccinia virus Ankara (MVA)-boost vaccination strategy,
57 ency virus (SHIV) and boosting with modified vaccinia virus Ankara (MVA)-SHIV vaccines in rhesus maca
60 /IL-15, SIV Gag/Pol/Env recombinant modified vaccinia virus Ankara (rMVA), and AT-2 SIVmac239 inactiv
61 f a candidate tuberculosis vaccine, modified vaccinia virus Ankara expressing antigen 85A (MVA85A), i
62 mine if mucosal vaccination using a modified vaccinia virus Ankara expressing human immunodeficiency
64 e questions in the context of a DNA/modified vaccinia virus Ankara SIV vaccine with and without gp140
65 V S and core antigen, followed by a modified Vaccinia virus Ankara vector to induce HBV-specific B- a
66 r SIVmac239 envelope-expressing DNA/modified vaccinia virus Ankara vector- and protein-based vaccinat
68 far, well-described vectors such as modified vaccinia virus Ankara, complex adenovirus, vesicular sto
69 impanzee adenovirus 63, ChAd63, and modified vaccinia virus Ankara, MVA, expressing AgAPN1, Pfs230-C,
70 ized with SIVmac239-based DNA-prime/modified vaccinia virus Ankara-boost vaccine regimens that includ
71 from rabbits and RM given identical modified vaccinia virus Ankara-prime/gp120-boost immunization reg
72 ther a chimpanzee adenovirus 63 and modified vaccinia virus Ankara-vectored vaccine expressing a mult
74 f this homolog during infection, we utilized vaccinia virus as a surrogate and showed that a vaccinia
75 as been developed using the immunogenic live vaccinia virus as a vaccine vector, expressing multiple
76 protein toxins, potently prevented spread of vaccinia virus as well as monkeypox virus, a human patho
79 and ovarian cancer models that an oncolytic vaccinia virus attracts effector T cells and induces PD-
80 t that dynamic phosphorylation involving the vaccinia virus B1 kinase and cellular enzymes is likely
82 The most well characterized role for the vaccinia virus B1 kinase is to facilitate viral DNA repl
86 viously characterized functions, B1 inhibits vaccinia virus B12 protein via a phosphorylation-depende
87 /182R with a functional version derived from vaccinia virus, B13R Our results show that MVA-B13R sign
88 HIV-1 antigens, with one of them lacking the vaccinia virus B19 protein, an inhibitor of the type I i
92 onocytogenes, vesicular stomatitis virus, or Vaccinia virus, but dispensable in the case of mouse cyt
93 gression are arrested in cells infected with vaccinia virus, but mass fluctuations continue until cel
94 uperinfection exclusion may be beneficial to vaccinia virus by selecting particles that can infect ce
96 red improved protection against Listeria and vaccinia virus challenges compared with the Armstrong bo
100 n a murine model of cutaneous infection with vaccinia virus, dermal gammadelta T cell numbers increas
101 nsight into the role of D4 as a co-factor of vaccinia virus DNA polymerase and allows a better unders
104 virion preparations, >88% of the theoretical vaccinia virus-encoded proteome was detected with high c
108 peptide-pulsed dendritic cells, recombinant vaccinia viruses encoding full-length T Ag or epitope mi
109 e isolation and characterization of numerous vaccinia virus enzymes, determination of the cap structu
110 cinia virus as a surrogate and showed that a vaccinia virus expressing MC021L-HA in place of F13L-HA
112 vides complete immune control of recombinant vaccinia virus expressing the same epitope if KCSRNRQYL
113 with a small-plaque phenotype.IMPORTANCE The vaccinia virus extracellular virion protein F13 is requi
114 aa 21-84), a recombinant envelope protein of vaccinia virus, for glycosaminoglycans (GAGs)-specific t
116 rhtrs1-amplified viruses, there arose in two vaccinia virus genes mutations that improved viral repli
118 ed interactions between genetically-modified vaccinia virus (GLV-1h68) and radiotherapy in melanoma c
119 fficacy of a replication-competent oncolytic vaccinia virus, GLV-1h153, carrying human sodium iodide
120 ORTANCE Previous studies have shown that the vaccinia virus glycoproteins A34 and B5 interact, and in
121 omologs of the Bcl-2 family of proteins, and vaccinia virus harbors antiapoptotic F1L that potently i
123 giosum virus, is predicted to encode several vaccinia virus homologs of EV-specific proteins, includi
124 modified by the insertion of the K1L and C7L vaccinia virus host range genes and express the clade C(
125 per by applying it to SIM and STED images of vaccinia virus in isolation and when engaged with host c
126 ges in the cytoskeleton, studies with mutant vaccinia viruses indicated that the cytoskeletal changes
127 RNAs were translationally upregulated during vaccinia virus-induced host protein synthesis shutoff.
128 ured the host mRNA translation rate during a vaccinia virus-induced host shutoff by analyzing total a
130 s rapidly and preferentially associated with vaccinia virus-infected cells in the LN paracortex, whic
131 , we analyzed the responses of host cells to vaccinia virus infection at both the transcriptional and
132 minor groove of double-stranded DNA, inhibit vaccinia virus infection by blocking viral DNA replicati
137 dependent of infection or during a surrogate vaccinia virus infection to identify how MC159 prevented
138 infection with either virus, after a cleared vaccinia virus infection, and during a persistent/latent
139 f oxidative phosphorylation increased during vaccinia virus infection, while inhibition of the cellul
152 nd vaccination of patients with AD with live vaccinia virus is contraindicated because of a heightene
153 present evidence that the impact of VRK2 on vaccinia virus is largely independent of BAF phosphoryla
155 on, and in the case of influenza B virus and vaccinia virus, ISG15 conjugation has been shown to rest
156 Until now, all known rifampin-resistant vaccinia virus isolates have contained missense mutation
159 factor (IRF) activation and ISG responses to vaccinia virus lacking F17 in both macrophages and lung
160 nd D10, but not of either enzyme alone, halt vaccinia virus late protein synthesis and inhibit virus
163 sion in other viral systems, did not prevent vaccinia virus membrane fusion, suggesting that these in
164 Upon infections with Toxoplasma gondii and vaccinia virus, mice with stabilized DC beta-catenin dis
165 revealed that this protein is essential for vaccinia virus morphogenesis and that its absence result
169 of a CXCR4 antagonist expressed by oncolytic vaccinia virus (OVV) against an invasive variant of the
170 mass spectrometry to identify more than 170 vaccinia virus pMHCI presented on infected mouse cells.
173 adults, with or without immunity to CMV and vaccinia virus (previous DryVax smallpox vaccination).
174 t rabbits immunized with a novel recombinant vaccinia virus prime-gp120 protein boost regimen generat
175 network is also assembled downstream of the Vaccinia virus protein A36 and the phagocytic Fc-gamma r
177 described a novel role for B1 in inhibiting vaccinia virus protein B12, which otherwise impedes an e
182 l involving serial passages of an attenuated vaccinia virus, rapid acquisition of inactivating frames
183 n and luciferase reporters demonstrated that vaccinia virus recognized MOCV intermediate and late pro
184 ia virus B1 protein is a homolog of cellular vaccinia virus-related kinases (VRKs) and is needed for
185 xhibits a remarkable degree of similarity to vaccinia virus-related kinases (VRKs), a family of cellu
187 depend on host cells to provide, to support vaccinia virus replication during a host shutoff.IMPORTA
188 iscovered that TRAF2 is a proviral factor in vaccinia virus replication in both HeLa cells and mouse
190 the beginning of the 1980s, research on the vaccinia virus replication mechanism has basically stall
195 lysis, we found that the fusion machinery of vaccinia virus resides exclusively in clusters at virion
197 perator sequence) into oncolytic recombinant vaccinia viruses (rVACV), which were further characteriz
198 ss-of-function analysis, we demonstrate that vaccinia virus's dependence on VRK2 is only observed in
200 measured after anti-CD3 stimulation or after vaccinia virus stimulation to measure T cells elicited a
201 The groups were then boosted with either the vaccinia virus strain NYVAC or a variant with improved r
203 ection of C57BL/6 mice with 1 x 10(7) PFU of vaccinia virus strain WR results in blepharitis, corneal
205 In this study, we show across a range of vaccinia virus strains, including the current clonal sma
207 l Medicine, Park et al. develop an oncolytic vaccinia virus that introduces truncated CD19 expression
212 antiviral protein PKR, enabled a recombinant vaccinia virus to replicate in resistant cells from huma
213 here that this expanded tropism of oncolytic vaccinia virus to the endothelial compartment is a conse
216 irst-ever use of tecovirimat as a preemptive vaccinia virus treatment strategy during induction chemo
217 e inhibitor 1 (SPI-1) of rabbitpox virus and vaccinia virus, two closely related orthopoxviruses, pre
219 of aggressive melanomas induced by oncolytic Vaccinia virus using RNA sequencing and found substantia
222 tions that (i) the replication and spread of vaccinia virus (VACV) and herpes simplex virus type 1 (H
226 produced in excess in cells infected with a vaccinia virus (VACV) decapping enzyme mutant and by wil
237 This work reveals the prototypic poxvirus Vaccinia virus (VACV) exploits cellular retrograde trans
238 ses; instead, we identified mutations in two vaccinia virus (VACV) genes, A24R and A35R, either of wh
240 assessed several routes of immunization with vaccinia virus (VACV) in protecting mice against ectrome
241 ically defined T cell epitopes recognized in vaccinia virus (VACV) infected C57BL/6 mice (expressing
243 -knockout CD8(+) TRM cells generated by skin vaccinia virus (VACV) infection were less effective at p
244 In establishing a respiratory infection, vaccinia virus (VACV) initially replicates in airway epi
250 elicited protective immunity.IMPORTANCE The vaccinia virus (VACV) K1 protein inhibits NF-kappaB acti
256 PKRs were able to restrict replication of a vaccinia virus (VACV) strain that lacks the PKR inhibito
257 high-throughput RNAi screen directed against vaccinia virus (VACV) to identify the VACV AAA+ ATPase D
262 virus (ECTV), a natural mouse pathogen, and vaccinia virus (VACV), a heterologous virus that neverth
263 arly every step in the reproductive cycle of vaccinia virus (VACV), a large DNA virus with about 200
272 are antigen-transporting cells that generate vaccinia virus (VACV)-specific T-cell responses, yet how
285 deep study of the covalent structure of the vaccinia virus virion using the various tools of contemp
288 Here, we show that after resolution of skin vaccinia virus (VV) infection, antigen-specific circulat
290 hocytic Choriomeningitis Virus (LCMV) WE and Vaccinia Virus (VV) infections with naive T(regs), we ob
291 ll responses were measured after anti-CD3 or vaccinia virus (VV) stimulation to measure T cells elici
292 Chimpanzee adenovirus-6 (AdC6) or -7 (AdC7), Vaccinia virus (VV), and DNA given by electroporation (D
293 We report here that the engineered oncolytic vaccinia virus VVWR-TK(-)RR(-)-Fcu1 can induce immunogen
294 y 10 passage rounds, the starting attenuated vaccinia virus was displaced by viruses with one fixed m
298 ymphocytic choriomeningitis virus (LCMV) and vaccinia virus, where the pathogens are cleared, but it
299 sease is induced by intradermal injection of vaccinia virus, whereas a protective response occurs wit
300 , we replaced the F13L open reading frame in vaccinia virus with an epitope-tagged version of MC021L.