ライフサイエンスコーパス: vacuolar

1 PI(3,5)P2 activates V-ATPases containing the vacuolar a-subunit isoform in Saccharomyces cerevisiae H

2 olar H(+)-ATPases (V-ATPases) containing the vacuolar a-subunit isoform Vph1 in yeast.

3 om both patients with VPS16 and VPS41 showed vacuolar abnormalities suggestive of impaired lysosomal

4 e regulatory circuitry that controls petunia vacuolar acidification and Arabidopsis hair development.

5 PP(i) synthase beyond its canonical role in vacuolar acidification and cytosolic PP(i) scavenging.

6 our study revealed an intimate link between vacuolar acidification, redox physiology, and virulence

7 t serves a job-sharing role with V-ATPase in vacuolar acidification.

8 rs glucose-dependent V-ATPase reassembly and vacuolar acidification.

9 We conclude that the a3-subunit of the vacuolar adenosine triphosphatase is not only responsibl

10 ted mitochondrial deterioration and identify vacuolar amino acid compartmentation as a cellular strat

11 The vacuolar amino acid transporter CAT2 from Solanum lycope

12 tance, they perform overlapping functions in vacuolar and secretory transport.

13 for association of RidL with retromer-coated vacuolar and tubular endosomes.

14 EhRab35 showed large vacuolar as well as punctate vesicular localization.

15 The a2-isoform of vacuolar ATPase (a2V) is uniquely and highly expressed o

16 screening and identified the V0 subunit C of vacuolar ATPase (ATP6V0C) as a Vpu-binding protein.

17 y bafilomycin A1 that binds and inhibits the vacuolar ATPase (V-ATPase) and by SopF, a bacterial effe

18 Here we identify vacuolar ATPase (V-ATPase) as an essential regulator of

19 ssion of ATP6v1g1, a critical subunit of the vacuolar ATPase (V-ATPase) pump.

20 In cancer cells, vacuolar ATPase (V-ATPase), a multi-subunit enzyme, is e

21 hich includes the Rag GTPases, Ragulator and vacuolar ATPase (V-ATPase).

22 using AD impedes acidification via defective vacuolar ATPase (vATPase) V0a1 subunit delivery to lysos

23 An exception is the assembly factor vacuolar ATPase assembly integral membrane protein (VMA2

24 lution cryoEM structures of a proton-pumping vacuolar ATPase from human cells, illuminating the glyco

25 luster into distinct pathways, including the vacuolar ATPase proton pump, Retromer, and Commander com

26 2 is an essential accessory component of the vacuolar ATPase required for lysosomal degradative funct

27 Mechanistically, iAs suppressed Vacuolar ATPase subunit VMA5 expression, impairing lysos

28 as overexpression of another subunit of the vacuolar ATPase, ATP6V0C", had no effect on tetherin exp

29 Mechanistically, TMEM106B binds vacuolar-ATPase accessory protein 1 (AP1).

30 TMEM106B deficiency reduces vacuolar-ATPase AP1 and V0 subunits, impairing lysosomal

31 A recent study identifies the host vacuolar-ATPase as essential to xenophagic clearance and

32 phorylated tau (e.g. synaptic protein VAMP2, vacuolar-ATPase subunit ATP6V0D1); therefore, we provide

33 tive to other secretory tissues and identify vacuolar ATPases as the likely mechanisms driving acidif

34 ch, SWitch/sucrose nonfermentable (SWI/SNF), vacuolar ATPases) and identified novel recurrent mutatio

35 Because GBPs are critical to target vacuolar bacteria, we determined whether GBP2 and GBP(ch

36 s have distinguished intensely colored intra-vacuolar bodies observed in the cells of highly colored

37 The vacuolar Ca(2+) channel YVC-1 was shown to be essential

38 However, increased vacuolar Ca(2+) concentrations caused channel occlusion,

39 ical excitability is suppressed by increased vacuolar Ca(2+) levels.

40 hannels: the plasma membrane, Cch1p, and the vacuolar calcium channel, Yvc1p.

41 cuolar fragmentation and mistargeting of the vacuolar carboxypeptidase CPY/Prc1, resulting in an extr

42 Accordingly, the vacuolar cargo begins to exit the Golgi near the midpoin

43 during Golgi maturation does a biosynthetic vacuolar cargo depart from the maturing cisternae?

44 Traffic of the vacuolar cargo requires the GGA clathrin adaptors, which

45 fluxes in the vacuole, cooperating with the vacuolar cation channel SlTPC1 and the two vacuolar H(+)

46 is activated genetically using a hyperactive vacuolar cation channel.

47 We have identified a vacuolar cationic amino acid transporter (PhCAT2) that c

48 AtRBOHD and Ca(2+) release dependent on the vacuolar channel TPC1.

49 t control of Na(+) -permeable slow- and fast-vacuolar channels that mediate the back-leak of Na(+) in

50 her, our study uncovers that the capacity of vacuolar Cl(-) loading in vascular cells plays a crucial

51 n scavenger histidine and was accompanied by vacuolar collapse and the appearance of serpin-protease

52 within the parasite lysosomal organelle (the vacuolar compartment or VAC) in turnover of autophagosom

53 sexually transmitted diseases, multiply in a vacuolar compartment, the inclusion.

54 togenes promotes egress of the bacteria from vacuolar compartments into the host cytosol often withou

55 asis via sequestration of labile Fe(2+) into vacuolar compartments.

56 osomal; the remainder are from lysosomal and vacuolar compartments.

57 entify Crocus sativus transporters mediating vacuolar crocin accumulation in stigmas.

58 for mitochondria and show that elevated non-vacuolar cysteine impairs mitochondrial respiration by l

59 The vacuolar cysteine protease legumain plays important func

60 ABA receptor targeting for vacuolar degradation occurs through the late endosome ro

61 tophagy is a conserved process involving the vacuolar degradation of cellular components.

62 Rsp5, Ear1, and Ssh4 mediate recognition and vacuolar degradation of PM proteins that escape or bypas

63 o show that turnover of SCM is mediated by a vacuolar degradation pathway triggered by ubiquitination

64 echanisms, together with distinct labels for vacuolar degradation, determines the final fate of the i

65 teins and coordination between autophagy and vacuolar degradation; and (5) identify future challenges

66 ligandins) of flavonoids, directing them for vacuolar deposition, the role of CsGSTF1 in selective an

67 e early replication without interfering with vacuolar disruption.

68 The spatiotemporal dynamics of vacuolar EhRab35 and its exchange with soluble cytosolic

69 This protection requires the vacuolar/endolysosomal signaling lipid PI3,5P2 We show t

70 -signaling pathway, one that likely leads to vacuolar engulfment of cytoplasmic proteins and recyclin

71 ulation of endolysosomal trafficking and the vacuolar environment by targeting the host RGS2 protein.

72 volves protrusion formation, engulfment, and vacuolar escape.

73 strating that the transport activity of this vacuolar exchanger has a profound impact on cytosolic ho

74 spiring vma2Delta cells, indicating that the vacuolar Fe(III) ions present in WT cells had been reduc

75 n accumulation of multivesicular bodies with vacuolar fragmentation and mistargeting of the vacuolar

76 vely active Acc1 in WT cells, alleviates the vacuolar fusion defects induced by Acc1 inhibition.

77 l function for PI(3,5)P(2) as a regulator of vacuolar fusion.

78 s based on a method developed to study yeast vacuolar fusion.

79 ors that appear to be able to regulate yeast vacuolar fusion.

80 t progress in the involvement of PRR for the vacuolar H(+) -ATPase activity.

81 ergic system, and work as a component of the vacuolar H(+) -ATPase.

82 The vacuolar H(+) ATPase (V-ATPase) is a complex multisubuni

83 omal acidification through inhibition of the vacuolar H(+)-adenosine triphosphatase (V-ATPase) increa

84 lated cells (ICs) express the proton pumping vacuolar H(+)-ATPase (V-ATPase) and are extensively invo

85 Here we report that vacuolar H(+)-ATPase (V-ATPase) inhibition differentiall

86 Eukaryotic vacuolar H(+)-ATPase (V-ATPase) is a multisubunit enzyme

87 The vacuolar H(+)-ATPase (V-ATPase) is a rotary motor enzyme

88 The vacuolar H(+)-ATPase (V-ATPase) is an ATP-dependent prot

89 The yeast vacuolar H(+)-ATPase (V-ATPase) of budding yeast (Saccha

90 Key to this restoration is activation of the vacuolar H(+)-ATPase (V-ATPase), a proton pump that acid

91 Moreover, ZnT2 directly interacted with vacuolar H(+)-ATPase (V-ATPase), and ZnT2 deletion impai

92 The vacuolar H(+)-ATPase (V-ATPase; V(1)V(o)-ATPase) is an A

93 A intercalated cells (A-ICs), which contain vacuolar H(+)-ATPase (V-type ATPase)-rich vesicles that

94 ns as regulators of autophagy by controlling vacuolar H(+)-ATPase activity and mTOR signalling.

95 proper levels of the V0a/V100 subunit of the vacuolar H(+)-ATPase and lysosomal pH.

96 dicate that recurrent stone formers with the vacuolar H(+)-ATPase B1 subunit p.E161K SNP exhibit a ur

97 nd lytic vacuole/lysosome, and contained the vacuolar H(+)-ATPase subunit a3, alias TCIRG1, a known a

98 r with mislocalization of the Golgi-enriched vacuolar H(+)-ATPase subunit isoform a2.

99 s required for full assembly and activity of vacuolar H(+)-ATPases (V-ATPases) containing the vacuola

100 Vacuolar H(+)-ATPases (V-ATPases) drive organelle acidif

101 e vacuolar cation channel SlTPC1 and the two vacuolar H(+)-pumps, SlAVP1 and SlVHA-A1, which in turn

102 howed that overexpression of the Arabidopsis vacuolar H(+)-pyrophosphatase gene AVP1 increases salt a

103 choline, thus giving rise to a net efflux of vacuolar H(+).

104 We identify that genetic disruption of the Vacuolar H+ ATPase (V-ATPase), the key proton pump for e

105 in receptor and is an essential component of vacuolar H+ ATPase.

106 Vacuolar H+-ATP complex (V-ATPase) is a multisubunit pro

107 ) is closely associated with a multi-subunit vacuolar H+-ATPase (V-ATPase).

108 its in hlh-30 mutant worms, and knockdown of vacuolar H+-ATPase 12 (vha-12) and its upstream regulato

109 We show that vacuolar H+-ATPase activity regulates sorting of O-glyco

110 One of these mutants, affecting the vacuolar H+-ATPase gene atp6ap1b, revealed specific requ

111 Vacuolar (H(+))-ATPase (V-ATPase) is fundamental in infl

112 Consistent with a role for Abc3 as vacuolar hemin exporter, results with hemin-agarose pull

113 The hexameric vacuolar HOPS (homotypic fusion and vacuole protein sort

114 e identified TRANSPORTER OF IBA1 (TOB1) as a vacuolar IBA transporter that limits lateral root format

115 f highly colored tissues, termed anthocyanic vacuolar inclusions (AVIs), from more globular, membrane

116 gar content and identify the polymorphism in vacuolar invertase inhibitor (INH2) gene from Indian non

117 ed glycoproteomic approach demonstrates that vacuolar invertase is glycosylated at all twelve potenti

118 One key protein involved in vacuolar iron storage is the iron importer Ccc1, which f

119 Our results show that by enhancing vacuolar iron transport in the endosperm, this essential

120 accharomyces cerevisiae) mutant defective in vacuolar iron transport.

121 e functionally characterized homologs of the VACUOLAR IRON TRANSPORTER (VIT).

122 GmVTL1a and GmVTL1b are members of the vacuolar iron transporter family and homologous to Lotus

123 ural studies to advance understanding of the vacuolar iron transporter family of membrane proteins fr

124 overexpression and purification of PfVIT, a vacuolar iron transporter homologue from the human malar

125 Overexpression of the Arabidopsis thaliana vacuolar iron transporter VIT1 in cassava accumulated th

126 Here, we characterize two nodule-specific Vacuolar iron Transporter-Like (VTL) proteins in Medicag

127 Vacuolar iron transporters (VITs) are a poorly understoo

128 non-amyloid inclusion bodies at the nuclear-vacuolar junction, and it utilizes cellular chaperones s

129 atical modeling, these results show that the vacuolar K(+)-conducting TPC1 and TPK1/TPK3 channels act

130 Phosphorylation of HOPS by the vacuolar kinase Yck3 renders fusion strictly dependent o

131 PS) motif within HOPS Vps41, a target of the vacuolar kinase Yck3, is dispensable for tethering and f

132 characteristic feature of Canavan disease, a vacuolar leukodystrophy resulting from deficiency of the

133 e and V(o) proton channel reconstituted into vacuolar lipid-containing nanodiscs, we further demonstr

134 t Env7 vacuole fusion/fission regulation and vacuolar localization are mediated through its Yck3-depe

135 Remarkably, vacuolar localization is required for NIa-Pro's ability

136 1 is important for multivesicular body (MVB)-vacuolar lysosome fusion, the last step of endocytosis r

137 studied fragment formation during homotypic vacuolar lysosome membrane fusion in Saccharomyces cerev

138 Vacuolar malate transport has been characterized at the

139 ponse directly targeting the parasitophorous vacuolar membrane (PVM) harbouring the parasite.

140 The parasitophorous vacuolar membrane (PVM) that surrounds the parasite is m

141 h its limiting membrane, the parasitophorous vacuolar membrane (PVM), collaborates with the parasite

142 n a vacuole delimited by the parasitophorous vacuolar membrane (PVM).

143 acuoles (BCVs) and subsequent rupture of the vacuolar membrane [1].

144 STK16-related kinases that localizes to the vacuolar membrane and downregulates vacuolar membrane fu

145 internalization from the cell surface to the vacuolar membrane and that the transporter Abc3 particip

146 omplex itself is reversibly recruited to the vacuolar membrane by glucose, but the requirements for i

147 vivo depends on YCK3, a gene that encodes a vacuolar membrane casein kinase I (CKI) homolog that non

148 It also points to regulation of vacuolar membrane dynamics via a novel Yck3-Env7 kinase

149 s to the vacuolar membrane and downregulates vacuolar membrane fusion.

150 lization of a GFP-tagged RAVE subunit to the vacuolar membrane in several mutants previously implicat

151 escribe the association between FaEO and the vacuolar membrane of strawberry fruits.

152 Vac17 also binds to Vac8, a vacuolar membrane protein.

153 ) Glucose-dependent RAVE localization to the vacuolar membrane required only intact V(o) complexes co

154 Inactivation of abc3(+), encoding a vacuolar membrane transporter, results in hem1Delta abc3

155 tes virulence (effector) proteins across its vacuolar membrane via the SPI-2 type III secretion syste

156 umulation of Atg8-positive structures at the vacuolar membrane, suggesting late defects in the autoph

157 Of note, experiments on vacuolar membrane-enriched vesicles isolated from yeast

158 cyanidin 3-O-glucoside (C3G) by Arabidopsis vacuolar membrane-enriched vesicles.

159 The vacuolar membrane-localized MavN, hypothesized to suppor

160 istarget multiple PM proteins de novo to the vacuolar membrane.

161 concentrations, Shu1-HA4 re-localizes to the vacuolar membrane.

162 on exchange at the plasma membrane (SOS1) or vacuolar membrane.

163 rch into ion transport across the plasma and vacuolar membranes of guard cells that drive stomatal mo

164 imaging and direct patch-clamping of apical vacuolar membranes revealed that ML1 mediates a PKA-acti

165 extracts, for the identification of putative vacuolar metabolite transporters, and we used it to iden

166 Vacuolar Mn stores are accessible reserves that can be m

167 these structures, polyP may, in turn, escort vacuolar Mn to a number of storage ligands, including ph

168 r nuclear position with some contribution by vacuolar morphology and of actin-dependent outer polar n

169 s in cells result in differential effects on vacuolar morphology and osmotic responses.

170 lly regulates triacylglycerol metabolism and vacuolar morphology through the long-chain fatty acyl-Co

171 is characterized by protein aggregation and vacuolar myopathology.

172 hagy proteins ULK1 and ULK2 in mice causes a vacuolar myopathy with ubiquitin and TDP-43-positive inc

173 le channels and discusses the energy cost of vacuolar Na(+) sequestration, under different scenarios.

174 rabidopsis thaliana Chloride Channel a) is a vacuolar NO(3) (-)/H(+) exchanger regulating stomata ape

175 evated expression of genes encoding putative vacuolar NO3(-) chloride channel transporters plus elect

176 e transferred between hydrophobic pockets of vacuolar NPC2 and membrane-protein NCR1.

177 Found in vacuolar or endolysosomal membranes, they regulate the c

178 in interactions that occur at the chlamydial vacuolar, or inclusion, membrane.

179 Genetic analysis in petunia identified two vacuolar P-ATPases, PH1 and PH5, which determine flower

180 nalyses showed that 4E02 targets A. thaliana vacuolar papain-like cysteine protease (PLCP) 'Responsiv

181 e conferring resistance to the intracellular vacuolar pathogen Toxoplasma gondii by inducing the dest

182 ective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma.

183 factors regulating antigen presentation from vacuolar pathogens.

184 cruitment of interferon-inducible GTPases to vacuolar pathogens.

185 ts confirm and extend the involvement of the vacuolar pathway in the cross-presentation of long pepti

186 terion to distinguish the cytosolic from the vacuolar pathway of cross-presentation.

187 rived immature dendritic cells occurred in a vacuolar pathway, making use of newly synthesized HLA-A2

188 ived immature dendritic cells also follows a vacuolar pathway.

189 proteasome acquires a role in the endocytic-vacuolar pathway.

190 Tighter coupling restored vacuolar pH when glucose was abundant and glycolysis ope

191 color is influenced by chemical decorations, vacuolar pH, the presence of copigments, and metal ions.

192 Moreover, in these seeds, aberrant vacuolar phenotypes were observed that were different fr

193 tinct spatial profiles in the root, but only vacuolar Pi sequestration corresponded with steady-state

194 ck Pi assimilation in wild-type plants and a vacuolar Pi transport mutant, and then measuring the sub

195 evelops a yeast model strain, devoid of both vacuolar polyP and polyphosphatases, that allows detecti

196 ets, we constructed a yeast strain devoid of vacuolar polyP by targeting the exopolyphosphatase Ppx1

197 lyP, and upon cell lysis, the release of the vacuolar polyP could nonphysiologically cause K-PPn of n

198 Here, we characterized the contribution of vacuolar polyP metabolism to K-PPn of two yeast proteins

199 rgeting K-PPn is only marginally affected by vacuolar polyP metabolism, Nsr1-targeting K-PPn is highl

200 ella replicates more rapidly compared to the vacuolar population, although the reasons for this are n

201 nd cathepsin B activation was independent of vacuolar processing enzyme (VPE).

202 t the C. burnetii secreted effector Coxiella vacuolar protein B (CvpB) binds PI(3)P and phosphatidyls

203 We validated the role of a set of vacuolar protein sorting (VPS) genes during infection, V

204 anoptera) warblers to identify a single gene-vacuolar protein sorting 13A (VPS13A)-that is associated

205 ompound heterozygous truncating mutations in vacuolar protein sorting 13C (VPS13C).

206 bunit EAP20/VPS25 (ELL-associated protein 20/vacuolar protein sorting 25) and the Bro1 proteins HD-PT

207 The class III PI3K Vacuolar protein sorting 34 (Vps34) plays a role in both

208 The vacuolar protein sorting 35 (VPS35) is a major component

209 r levels of one of its major components, the vacuolar protein sorting 35 (VPS35), has been reported i

210 AP2M1 (AP-2 adaptor protein), RAB5A, VPS35 (vacuolar protein sorting 35 homolog), and M6PR (mannose

211 Mutations in the vacuolar protein sorting 35 ortholog (VPS35) gene repres

212 reviously uncharacterized factors, including vacuolar protein sorting 37 homolog A (VPS37A), transmem

213 pinocytosis was blocked by dominant-negative vacuolar protein sorting 4 (Vps4), indicating that the W

214 or transport) components ESCRT-III and VPS4 (vacuolar protein sorting 4).

215 from Myzus persicae associates with the host Vacuolar Protein Sorting Associated Protein52 (VPS52).

216 intracellular multiplication, CteG induced a vacuolar protein sorting defect when expressed in Saccha

217 loss of other retromer components SNX-3 and vacuolar protein sorting-associated protein 35 (VPS-35)

218 REQUIRED FOR ENDOSOMAL SORTING1 (FYVE1) and VACUOLAR PROTEIN SORTING23A (VPS23A), components of the

219 Yeast Vps13 is involved in vacuolar protein transport and, like hVps13A, participat

220 pholipid transporter VPS13, humans have four vacuolar protein-sorting (VPS) protein 13 isoforms.

221 ve to salt stress and partially mislocalizes vacuolar proteins to the apoplast, indicating a role in

222 f GARP combined with mass spectrometry based vacuolar proteomics and lipidomics to show that recyclin

223 We selected the vacuolar proton ATPase inhibitor bafilomycin A1 for anal

224 CeMM induced transcription of vacuolar proton pump subunits in hlh-30 mutant worms, an

225 lagellar calcium binding protein) and TcVP1 (vacuolar proton pyrophosphatase), and two proteins of un

226 ression of AVP1, encoding type 1 ARABIDOPSIS VACUOLAR PYROPHOSPHATASE1.

227 eoliposomes bearing a Rab:GTP and either the vacuolar R-SNARE or one of the three integrally anchored

228 Two HOPS subunits bind vacuolar Rabs for tethering, another binds the Qc SNARE,

229 s a central trafficking hub where secretory, vacuolar, recycling, and endocytic pathways merge.

230 bules and promoted their elongation, driving vacuolar remodeling, receptor recycling, and resolution

231 ere affected for lysis of the nascent SCV or vacuolar replication in epithelial cells, indicating tha

232 he ankB mutant of strain AA100/130b in intra-vacuolar replication.

233 Vacuolar residence provides these pathogens with a defin

234 anslocate at least 28 effector proteins from vacuolar-resident bacteria into host cells.

235 eting them for degradation via the endosomal/vacuolar RSL1-dependent pathway or 26S proteasome.

236 the first set of host factors modulating Lm vacuolar rupture and cytoplasmic access in epithelial ce

237 ntify epithelial cell factors involved in Lm vacuolar rupture, among them the serine/threonine kinase

238 Transformation to AsIII and vacuolar sequestration is believed to be the As detoxifi

239 tions of Pi uptake, metabolic recycling, and vacuolar sequestration to cytosolic Pi homeostasis in Ar

240 Pi uptake, metabolic recycling, and vacuolar sequestration were distinguished in each zone b

241 abilize anthocyanins, participating in their vacuolar sequestration, a function conserved across the

242 KEY MESSAGE: The vacuolar SlCAT2 was cloned, over-produced in E. coli and

243 es, assembly requires catalysis by HOPS, the vacuolar SM and tethering complex.

244 T7) function and to a lesser extent on VTI11 vacuolar SNARE activity.

245 HOPS also has specific affinities for the vacuolar SNAREs and catalyzes SNARE complex assembly, bu

246 We now show that yeast vacuolar SNAREs assemble spontaneously into RQaQbQc comp

247 HOPS-tethered membranes and all four vacuolar SNAREs formed a complex that underwent an even

248 The assembly of yeast vacuolar SNAREs into complexes for fusion can be studied

249 mbrane fusion, and recent studies with yeast vacuolar SNAREs uncovered asymmetry in the results of li

250 Vps34 is also required for proper vacuolar sorting and autophagy.

251 We show that vacuolar storage capacity in the leaf is a major determi

252 Vacuolar storage is achieved through the action of the Z

253 raphs indicating enlarged vacuoles suggested vacuolar storage of NO3(-) Triacylglycerol concentration

254 4) transporters to remobilize iron from seed vacuolar stores and thereby acquire photosynthetic compe

255 Understanding the active nature of the vacuolar structures and the mechanisms of vacuole-mediat

256 g have significantly altered our view of the vacuolar structures and their dynamics.

257 limited information on the modulation of the vacuolar structures by pathogens, but recent research ha

258 We discovered novel vacuolar structures that form in LPS-activated but not r

259 some plants, they accumulate as discrete sub-vacuolar structures.

260 an actively accumulate infectious virions in vacuolar subcellular structures mostly connected to the

261 eview focussing on the role and targeting of vacuolar substructure in plant immunity and pathogenesis

262 In this transition, the vacuolar Suc importers and exporters TONOPLAST SUGAR TRA

263 Here, we report a novel vacuolar sugar transporter (ClVST1) identified through m

264 surveillance of a SNARE protein in the endo-vacuolar system.

265 ts accumulation and concentration within the vacuolar system.

266 In conclusion, vacuolar tannins (which are the main seed phenolics extr

267 s quantified from fractionation (fraction 1, vacuolar tannins; fraction 2, hydrogen bonded tannins; f

268 demonstrate that mating pheromone stimulates vacuolar targeting of a cytoplasmic reporter protein and

269 able fluorescent secretory cargo by adding a vacuolar targeting signal.

270 ance is regulated by endosomal recycling and vacuolar targeting, but the role of vacuole-related prot

271 ia2 is required to sustain pheromone-induced vacuolar targeting.

272 The yeast vacuolar tethering/SM complex HOPS (homotypic fusion and

273 d rescues the salt sensitivity and defective vacuolar trafficking of the tno1 mutant.

274 oteins to the apoplast, indicating a role in vacuolar trafficking.

275 ibly other ABCC proteins are involved in the vacuolar transport of anthocyanins and other flavonoids

276 lutathione S-transferases related with their vacuolar transport were up-accumulated in fruits kept at

277 function of Vps13 protein in endocytosis and vacuolar transport, although the level of the protein is

278 ern previously shown to be determined by the vacuolar transporter VIT1.

279 ation revealed: (i) the major role played by vacuolar transporters in regulating HCN content; (ii) th

280 id oxygenation upregulated2 (fou2) mutant in vacuolar two-pore channel 1 (TPC1(D454N) ) displays high

281 Vacuolar type ATPase (V-ATPase) has recently emerged as

282 imary murine CTLs that the a3-subunit of the vacuolar-type (H(+))-adenosine triphosphatase is require

283 Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are

284 ses energy from proton-pumping vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases).

285 cells show impaired cleavage or shedding of vacuolar-type ATPase (V-ATPase) subunits Ac45 and proren

286 Proton-translocating vacuolar-type ATPases (V-ATPases) are necessary for nume

287 rom inhibition of proton pumping activity of vacuolar-type H(+)-ATPase (v-ATPase).

288 Here, we show strong evidence that vacuolar-type H(+)-ATPase and plasma-accessible carbonic

289 din B is structurally similar to more potent vacuolar-type H(+)-ATPase inhibitors, which all inhibite

290 The vacuolar-type H(+)-ATPases (V-ATPase) hydrolyze ATP to p

291 Vacuolar-type H(+)-ATPases (V-ATPases) contribute to pH

292 determinant of acidic pH at the Golgi is the vacuolar-type H(+)-translocating ATPase (V-ATPase), whos

293 expression of one particular subunit of the vacuolar-type H+ ATPase (V-ATPase), which is responsible

294 ry of recurrent mutations in subunits of the vacuolar-type H+-translocating ATPase (v-ATPase) in foll

295 terized by proteasome and TAP dependency, or vacuolar, usually believed to be proteasome and TAP inde

296 nts, the precise molecular mechanism whereby vacuolar (V-type) ATP synthase fulfills its biological f

297 focused on the relative contributions of the vacuolar versus cytosolic pathways of antigen processing

298 ous short-chain PI(3,5)P2 to Vph1-containing vacuolar vesicles activates V-ATPase activity and proton

299 ochemical characterization of isolated yeast vacuolar vesicles, we demonstrate that addition of exoge

300 ted a manganese transporter mutant but not a vacuolar zinc transporter mutant.